DMFold results for DMF543805713

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DMF543805713 (1279 residues) >protein-A MSNQGEYPEDNRVGKHEPHDLSLTRRDLIKVSAATAATAVVYPHSTLAASVPAATPAPEI MPLTLKVNGKTEQLEVDTRTTLLDTLRENLHLIGTKKGCDHGQCGACTVLVNGRRLNACL TLAVMHQGAEITTIEGLGSPDNLHPMQAAFIKHDGFQCGYCTSGQICSSVAVLKEIQDGI PSHVTVDLVSAPETTADEIRERMSGNICRCGAYANILAAIEDAAGEIKS >protein-B MKAFTYERVNTPAEAALSAQRVPGAKFIAGGTNLLDLMKLEIETPTHLIDVNGLGLDKIE VTDAGGLRIGALVRNTDLAAHERVRRDYAVLSRALLAGASGQLRNQATTAGNLLQRTRCP YFYDTNQPCNKRLPGSGCAALEGFSRQHAVVGVSEACIATHPSDMAVAMRLLDAVVETIT PEGKTRSITLADFYHPPGKTPHIETALLPGELIVAVTLPPPLGGKHIYRKVRDRASYAFA LVSVAAIIQPDGSGRVALGGVAHKPWRIEAADAQLSQGAQAVYDTLFASAHPTAENTFKL LLAKRTLASVLAEARAQA >protein-C MKFDKPAGENPIDQLKVVGRPHDRIDGPLKTTGTARYAYEWHEEAPNAAYGYIVGSAIAK GRLTALDTDAAQKAPGVLAVITASNAGALGKGDKNTARLLGGPTIEHYHQAIALVVAETF EQARAAASLVQAHYRRNKGAYSLADEKQAVNQPPEDTPDKNVGDFDGAFTSAAVKIDATY TTPDQSHMAMEPHASMAVWDGNKLTLWTSNQMIDWCRTDLAKTLKVPVENVRIISPYIGG GFGGKLFLRSDALLAALAARAVKRPVKVMLPRPSIPNNTTHRPATLQHLRIGADQSGKIT AISHESWSGNLPGGTPETAVQQSELLYAGANRHTGLRLATLDLPEGNAMRAPGEAPGLMA LEIAIDELAEKAGIDPVEFRILNDTQVDPADPTRCFSRRQLIECLRTGADKFGWKQRNAT PGQVRDGEWLVGHGVAAGFRNNLLEKSGARVHLEQNGTVTVETDMTDIGTGSYTILAQTA AEMLGVPLEQVAVHLGDSSFPVSAGSGGQWGANTSTSGVYAACMKLREMIASAVGFDPEQ SQFADGKITNGTRSATLHEATAGGRLTAEESIEFGTLSKEYQQSTFAGHFVEVGVHSATG EVRVRRMLAVCAAGRILNPKTARSQVIGAMTMGMGAALMEELAVDDRLGYFVNHDMAGYE VPVHADIPKQEVIFLDDTDPISSPMKAKGVGELGLCGVSAAIANAVYNATGIRVRDYPIT LDKLLDKLPDVV

ID. of chain chain Length of chain Models of Chain Sequence A DMF543805713-model1-A 229 MSNQGEYPEDNRVGKHEPHDLSLTRRDLIKVSAATAATAVVYPHSTLAASVPAATPAPEIMPLTLKVNGKTEQLEVDTRT TLLDTLRENLHLIGTKKGCDHGQCGACTVLVNGRRLNACLTLAVMHQGAEITTIEGLGSPDNLHPMQAAFIKHDGFQCGY CTSGQICSSVAVLKEIQDGIPSHVTVDLVSAPETTADEIRERMSGNICRCGAYANILAAIEDAAGEIKS B DMF543805713-model1-B 318 MKAFTYERVNTPAEAALSAQRVPGAKFIAGGTNLLDLMKLEIETPTHLIDVNGLGLDKIEVTDAGGLRIGALVRNTDLAA HERVRRDYAVLSRALLAGASGQLRNQATTAGNLLQRTRCPYFYDTNQPCNKRLPGSGCAALEGFSRQHAVVGVSEACIAT HPSDMAVAMRLLDAVVETITPEGKTRSITLADFYHPPGKTPHIETALLPGELIVAVTLPPPLGGKHIYRKVRDRASYAFA LVSVAAIIQPDGSGRVALGGVAHKPWRIEAADAQLSQGAQAVYDTLFASAHPTAENTFKLLLAKRTLASVLAEARAQA C DMF543805713-model1-C 732 MKFDKPAGENPIDQLKVVGRPHDRIDGPLKTTGTARYAYEWHEEAPNAAYGYIVGSAIAKGRLTALDTDAAQKAPGVLAV ITASNAGALGKGDKNTARLLGGPTIEHYHQAIALVVAETFEQARAAASLVQAHYRRNKGAYSLADEKQAVNQPPEDTPDK NVGDFDGAFTSAAVKIDATYTTPDQSHMAMEPHASMAVWDGNKLTLWTSNQMIDWCRTDLAKTLKVPVENVRIISPYIGG GFGGKLFLRSDALLAALAARAVKRPVKVMLPRPSIPNNTTHRPATLQHLRIGADQSGKITAISHESWSGNLPGGTPETAV QQSELLYAGANRHTGLRLATLDLPEGNAMRAPGEAPGLMALEIAIDELAEKAGIDPVEFRILNDTQVDPADPTRCFSRRQ LIECLRTGADKFGWKQRNATPGQVRDGEWLVGHGVAAGFRNNLLEKSGARVHLEQNGTVTVETDMTDIGTGSYTILAQTA AEMLGVPLEQVAVHLGDSSFPVSAGSGGQWGANTSTSGVYAACMKLREMIASAVGFDPEQSQFADGKITNGTRSATLHEA TAGGRLTAEESIEFGTLSKEYQQSTFAGHFVEVGVHSATGEVRVRRMLAVCAAGRILNPKTARSQVIGAMTMGMGAALME ELAVDDRLGYFVNHDMAGYEVPVHADIPKQEVIFLDDTDPISSPMKAKGVGELGLCGVSAAIANAVYNATGIRVRDYPIT LDKLLDKLPDVV Click the Chain column or image, you can go into the individual page to check the individual Chain modeling results.

Alignment depth: Nf=125.815, number of sequences=4732 Download multiple sequence alignment in aln format. Download multiple sequence alignment in a3m format.

Contact Map Distance Map

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Click to view Rank Download PDB pTM-score 1 model1.pdb.gz 0.96 2 model2.pdb.gz 0.96 3 model3.pdb.gz 0.96 4 model4.pdb.gz 0.96 5 model5.pdb.gz 0.96 (a) DMFold generates a large set of structural models by different MSAs as inputs. These models are ranked by predicted TM-score (pTM-score for multimer) or predicted LDDT (pLDDT for monomer) and top 5 models are selected with the highest predicted scores.

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Top 10 structural analogs in PDB (as identified by US-align) Click to view Rank PDB Hit TM-score RMSDa IDENa Cov. Download Alignment 1 5g5g 0.95 0.44 1.00 0.95 Download 2 5y6q 0.90 2.26 0.42 0.92 Download 3 1rm6 0.87 2.72 0.29 0.91 Download 4 1sb3 0.87 2.76 0.29 0.91 Download 5 1t3q 0.86 2.59 0.26 0.89 Download 6 1n62 0.85 2.77 0.25 0.89 Download 7 1n60 0.85 2.75 0.25 0.89 Download 8 1ffu 0.85 2.87 0.25 0.89 Download 9 1n63 0.85 2.79 0.25 0.89 Download 10 1ffv 0.85 2.88 0.25 0.89 Download (b) Query structure is shown in cartoon, while the structural analog is displayed using backbone trace. (b) Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library. (c) RMSDa is the RMSD between residues that are structurally aligned by TM-align. (d) IDENa is the percentage sequence identity in the structurally aligned region. (e) Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Molecular Function (MF) GO term FreqGO Chain ID Name GO:0016491 1.00 A,B,C oxidoreductase activity GO:1901363 1.00 A,B,C heterocyclic compound binding GO:0097159 1.00 A,B,C organic cyclic compound binding GO:0050660 1.00 A,B,C flavin adenine dinucleotide binding GO:0016903 0.67 A,C oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0004854 0.67 A,C xanthine dehydrogenase activity GO:0016725 0.33 A oxidoreductase activity, acting on CH or CH2 groups GO:0003824 0.33 B catalytic activity GO:0043167 0.33 B ion binding GO:0000166 0.33 B nucleotide binding GO:0043168 0.33 B anion binding GO:0016614 0.33 B oxidoreductase activity, acting on CH-OH group of donors GO:0043169 0.33 B cation binding GO:0050662 0.33 C coenzyme binding GO:0016726 0.33 C oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Download full result of the above consensus prediction. Click the graph to show a high resolution version. (a) CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template. (b) FreqGO is the frequency of predicted GO terms with a CscoreGO greater than 0.5 among all terms within each chain of a complex protein. The FreqGO values range between [0-1], where a higher value indicates a greater proportion of high-confidence predictions (CscoreGO > 0.5) in the function annotation of the protein chain. (c) Chain ID indicates the specific protein chain in the complex that contains the GO term with a CscoreGO greater than 0.5. This identifier helps in associating high-confidence GO terms with their respective chains. (d) The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. [0.4,0.5) [0.5,0.6) [0.6,0.7) [0.7,0.8) [0.8,0.9) [0.9,1.0] Biological Process (BP) GO term FreqGO Chain ID Name GO:0044237 1.00 A,B,C cellular metabolic process GO:0044763 1.00 A,B,C single-organism cellular process GO:1901564 1.00 A,B,C organonitrogen compound metabolic process GO:0044281 1.00 A,B,C small molecule metabolic process GO:0044710 0.67 A,C single-organism metabolic process GO:1901360 0.67 A,B organic cyclic compound metabolic process GO:0046483 0.67 A,B heterocycle metabolic process GO:0044238 0.67 A,B primary metabolic process GO:0055086 0.67 A,B nucleobase-containing small molecule metabolic process GO:0072521 0.67 A,C purine-containing compound metabolic process GO:0019439 0.67 A,C aromatic compound catabolic process GO:1901565 0.67 A,C organonitrogen compound catabolic process GO:1901361 0.67 A,C organic cyclic compound catabolic process GO:0044712 0.67 A,C single-organism catabolic process GO:0009115 0.67 A,C xanthine catabolic process GO:0006139 0.67 B,C nucleobase-containing compound metabolic process GO:0006725 0.33 A cellular aromatic compound metabolic process GO:0046700 0.33 A heterocycle catabolic process GO:0044270 0.33 A cellular nitrogen compound catabolic process GO:0006144 0.33 A purine nucleobase metabolic process GO:0006145 0.33 A purine nucleobase catabolic process GO:0009987 0.33 B cellular process GO:0008152 0.33 B metabolic process GO:0071704 0.33 B organic substance metabolic process GO:0044699 0.33 B single-organism process GO:0006807 0.33 B nitrogen compound metabolic process GO:0055114 0.33 B oxidation-reduction process GO:0009112 0.33 C nucleobase metabolic process Download full result of the above consensus prediction. Click the graph to show a high resolution version. (a) CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template. (b) FreqGO is the frequency of predicted GO terms with a CscoreGO greater than 0.5 among all terms within each chain of a complex protein. The FreqGO values range between [0-1], where a higher value indicates a greater proportion of high-confidence predictions (CscoreGO > 0.5) in the function annotation of the protein chain. (c) Chain ID indicates the specific protein chain in the complex that contains the GO term with a CscoreGO greater than 0.5. This identifier helps in associating high-confidence GO terms with their respective chains. (d) The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. [0.4,0.5) [0.5,0.6) [0.6,0.7) [0.7,0.8) [0.8,0.9) [0.9,1.0] Cellular Component (CC) GO term FreqGO Chain ID Name GO:0005829 1.00 A,B,C cytosol GO:0044424 0.67 A,C intracellular part GO:0044464 0.33 A cell part GO:0005737 0.33 B cytoplasm GO:0044421 0.33 B extracellular region part GO:0043227 0.33 B membrane-bounded organelle GO:0043231 0.33 B intracellular membrane-bounded organelle GO:0005777 0.33 B peroxisome GO:0005615 0.33 B extracellular space GO:0005576 0.33 B extracellular region GO:0016020 0.33 B membrane Download full result of the above consensus prediction. Click the graph to show a high resolution version. (a) CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template. (b) FreqGO is the frequency of predicted GO terms with a CscoreGO greater than 0.5 among all terms within each chain of a complex protein. The FreqGO values range between [0-1], where a higher value indicates a greater proportion of high-confidence predictions (CscoreGO > 0.5) in the function annotation of the protein chain. (c) Chain ID indicates the specific protein chain in the complex that contains the GO term with a CscoreGO greater than 0.5. This identifier helps in associating high-confidence GO terms with their respective chains. (d) The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. [0.4,0.5) [0.5,0.6) [0.6,0.7) [0.7,0.8) [0.8,0.9) [0.9,1.0]

Top 5 EC Number Rank FreqEC EC Number Chain ID 1 1.00 1.2.99.2  A,B,C 2 1.00 1.17.1.4  A,B,C 3 1.00 1.17.3.2  A,B,C 4 0.67 1.2.99.7  A,C 5 0.67 1.2.-.-  A,C (a) FreqEC is the frequency of predicted Enzyme Commission (EC) number among all terms within each chain of a complex protein. FreqEC values range in between [0-1]; (c) Chain ID indicates the specific protein chain in the complex that contains the Enzyme Commission (EC) number.

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Template proteins with similar binding site: Click to view Rank PDB Hit TM-score RMSDa IDENa Cov. Download Complex 1 5g5g 0.953 0.44 1.000 0.955 Download 2 5y6q 0.895 2.26 0.420 0.923 Download 3 1rm6 0.868 2.72 0.290 0.909 Download 4 1sb3 0.867 2.76 0.290 0.909 Download 5 1t3q 0.858 2.59 0.260 0.893 Download 6 1n62 0.848 2.77 0.250 0.888 Download 7 1n60 0.848 2.75 0.250 0.887 Download 8 1ffu 0.847 2.87 0.250 0.890 Download 9 1n63 0.847 2.79 0.250 0.887 Download 10 1ffv 0.847 2.88 0.250 0.890 Download   Click on the radio buttons to visualize predicted binding site and residues. (a) TM-score is a measure of global structural similarity between query and template protein. (b) RMSDa the RMSD between residues that are structurally aligned by TM-align. (c) IDENa is the percentage sequence identity in the structurally aligned region. (d) Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

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