6lja A 1.98 BS01 SGN B 1 L69 D70 G71 R332 A334 D335 N336 H337 H555 R648 L46 D47 G48 R309 A311 D312 N313 H314 H532 R625 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAYFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSHALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6lja A 1.98 BS02 UAP B 1 F282 H337 Q340 Y390 H555 R579 G581 F582 F259 H314 Q317 Y367 H532 R556 G558 F559 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAYFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSHALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6lja A 1.98 BS03 CA A 1 Q340 W384 N386 Y390 N394 Q317 W361 N363 Y367 N371 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAYFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSHALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6lja A 1.98 BS04 CA A 2 H439 G440 R546 A556 L557 N559 H416 G417 R523 A533 L534 N536 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAYFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSHALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6ljh A 1.80 BS01 NAD A 1 C48 H49 T50 C177 T181 G202 G204 T205 V206 D226 V227 K231 C273 T274 G275 V276 L279 I297 G298 A299 C43 H44 T45 C172 T176 G197 G199 T200 V201 D221 V222 K226 C268 T269 G270 V271 L274 I292 G293 A294 1.1.1.- PGVITCKAAVVWESSGPVVLEEIRVDPPKASEVRIKMLCASLCHTDVLCTKGFPIPLFPRIPGHEGVGVIESIGKDAKGLKPGDIVMPLYLGECGQCLNCKTGKTNLCHVYPPSFSGLMNDGTSRMSIARTGESIYHFASCSTWTEYAVADCNYVLKINPKISYPHASFLSCGFTTGFGATWRETQVSKGSSVAVFGIGTVGLGVIKGAQLQGASKIIGVDVNQYKAAKGKVFGMTDFINPKDHPDKSVSELVKELTHGLGVDHCFECTGVPSLLNEALEASKIGIGTVVPIGAGGEASVAINSLILFSGRTLKFTAFGGVRTQSDLPVIIDKCLNKEIQLDELLTHEIHLDNIQEAFEILKKPDCVKILIKFLEHH 6ljh A 1.80 BS02 ZN A 1 C99 C102 C105 C113 C94 C97 C100 C108 1.1.1.- PGVITCKAAVVWESSGPVVLEEIRVDPPKASEVRIKMLCASLCHTDVLCTKGFPIPLFPRIPGHEGVGVIESIGKDAKGLKPGDIVMPLYLGECGQCLNCKTGKTNLCHVYPPSFSGLMNDGTSRMSIARTGESIYHFASCSTWTEYAVADCNYVLKINPKISYPHASFLSCGFTTGFGATWRETQVSKGSSVAVFGIGTVGLGVIKGAQLQGASKIIGVDVNQYKAAKGKVFGMTDFINPKDHPDKSVSELVKELTHGLGVDHCFECTGVPSLLNEALEASKIGIGTVVPIGAGGEASVAINSLILFSGRTLKFTAFGGVRTQSDLPVIIDKCLNKEIQLDELLTHEIHLDNIQEAFEILKKPDCVKILIKFLEHH 6ljh A 1.80 BS03 ZN A 2 C48 H69 E70 C177 C43 H64 E65 C172 1.1.1.- PGVITCKAAVVWESSGPVVLEEIRVDPPKASEVRIKMLCASLCHTDVLCTKGFPIPLFPRIPGHEGVGVIESIGKDAKGLKPGDIVMPLYLGECGQCLNCKTGKTNLCHVYPPSFSGLMNDGTSRMSIARTGESIYHFASCSTWTEYAVADCNYVLKINPKISYPHASFLSCGFTTGFGATWRETQVSKGSSVAVFGIGTVGLGVIKGAQLQGASKIIGVDVNQYKAAKGKVFGMTDFINPKDHPDKSVSELVKELTHGLGVDHCFECTGVPSLLNEALEASKIGIGTVVPIGAGGEASVAINSLILFSGRTLKFTAFGGVRTQSDLPVIIDKCLNKEIQLDELLTHEIHLDNIQEAFEILKKPDCVKILIKFLEHH 6ljk A 1.39 BS01 III B 1 R71 Q83 H158 V221 W222 F223 G224 E225 N226 L227 L232 V253 V254 Y255 P256 M259 R38 Q50 H125 V188 W189 F190 G191 E192 N193 L194 L199 V220 V221 Y222 P223 M226 2.3.1.- 32163813 ARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALA 6ljk A 1.39 BS02 ZN A 1 C166 C169 C207 C212 C133 C136 C174 C179 2.3.1.- 32163813 ARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALA 6ljk A 1.39 BS03 GUA B 1 R71 Y102 R105 I142 H158 V221 R38 Y69 R72 I109 H125 V188 2.3.1.- 32163813 ARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALA 6ljl A 1.73 BS01 SGN B 1 D70 G71 S226 N336 H337 S554 F582 R648 D47 G48 S203 N313 H314 S531 F559 R625 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAAFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSAALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6ljl A 1.73 BS02 IDS B 1 S226 H337 R579 G581 F582 K755 S203 H314 R556 G558 F559 K732 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAAFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSAALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6ljl A 1.73 BS03 SGN B 2 R230 R233 M341 E489 K491 P492 K755 R757 R207 R210 M318 E466 K468 P469 K732 R734 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAAFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSAALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6ljl A 1.73 BS04 GCD B 1 A389 V393 S442 R757 A366 V370 S419 R734 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAAFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSAALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6ljl A 1.73 BS05 CA A 1 Q340 W384 N386 A390 N394 Q317 W361 N363 A367 N371 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAAFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSAALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6ljl A 1.73 BS06 CA A 2 H439 G440 R546 A556 L557 N559 H416 G417 R523 A533 L534 N536 AVIKVSEETLMYEVRATPSPADGTYVKVNPPRFMWPDKFPHLGPVLDGVPGQVDEKPKVVYRIRISQDKNFRKDVLTGERAWAFFNPFQCLAQGKWYWQHAYVTPEGTEEWSPVYQFYIDKDTPEFNPPTLEKVLARYPSHHPRVLLDADDWENIIAKNNNNPEARTYMDKASQCISRPLKHLQEEIDTTNVVTLTNIVQRESALIRESRKIVDREEANVEALVRAYLLTKDEKYYREGINRLSEILSWQKSKYFAGDFNLSTLLSMSTSAYDGFYNLLSPEEKQLLLDNIRKIGDKFYNEYVNHLENRIADNHVWQMTFRILTMAAFATVGEIPEASVWTDYCYNEWISRLPGLHKDGGWHNGDAAFHVNIRTLIEVPVFFSRISGFNFFADPWYNNNALYVIYQQPPFSKSGGHGNSHEGQRSPNGGRIGYADALARECNNPWAAAYVHEIMQEDPDILSKAFEAKPADLTWYRCTTPKERPAYSKHLSELPESKVFKQTGTALMNTDIGHHANNAMLSFRSSPYGSTSAALANQNAFNTFFGGKAIFYSSGHRTGFTDDHCMYAYRNTRAHNSILVNGMGQKIGTEGYGWIPRYYEGEEISYVVGDASNAYGKVVSPLWLERGRLSGTQFTPEKGWDENKLEFFRRHVVQLGRSGLFVVYDELAGKEPVEWNYLLHTVELPMEVVKEEGGLRILGKNKADGISIAHLYSSQEMTYAQTDTFFVAALDWKKRLGKALPNHYHFTATTAPCNKVFFLNIIDVHGNNRADAVINHQGNHITVEGWVIECNLDSEGKAFLHIENKQNGASLDFNYNSNKGATTIVDQVDGKRIEKRLVDSLP 6lk9 A 2.10 BS01 FE A 1 E23 E58 H61 E22 E57 H60 PSVRQNFHQDSEAAINRQINLELYASYVYLSMAYYFDRDDQALHNFAKFFKNQSHEEREHAEKLMKVQNQRGGRIFLQDIKKPEKDEWVSGVEALESALQLEKSVNQSLLDLHKVCSEHNDPHMCDFIETHYLDEQVKSIKELGDWVTNLRRMGAPQNGMAEYLFDKHTLG 6lkc A 2.00 BS01 FMN A 1 G101 A102 M103 A104 N154 S183 K217 E265 S268 G269 G307 G308 G329 S330 Q333 W476 A480 G89 A90 M91 A92 N142 S171 K205 E253 S256 G257 G295 G296 G317 S318 Q321 W464 A468 1.3.1.9 SPWPWLVTDTNISFDVTVMEQQLRDFSRGCYVVNHNEKGVGIAQTAELVADQASNSLPVAAFTPALGTESLGDSNFRRVHGVKYAYYAGAMANGISSEELVIALGQAGILCSFGAAGLIPSRVEKAINRIQAALPNGPYMFNLIHSPSEPALERGSVELFLKHKVRTVEASAFLGLTPQIVYYRAAGLSRDAQGNIVVANKVIAKVSRTEVAEKFMMPAPAKMLQKLVDEGSITPEQMELAQLVPMADDITAEADSGGHTDNRPLVTLLPTILALKEEIQTKYQYPTPIRVGCGGGVGTPDAALATFNMGAAYIVTGSVNQACVEAGASEHTRKLLSTTEMADVTMAPAADMFEMGVKLQVVKRGTLFPMRANKLYELYTRYDSIEAIPADEREKLEKQVFRSTLDDIWAGTVAHFNERDPKQIERATDNPKRKMALIFRWYLGLSSRWSNSGETGREMDYQIWAGPALGAFNQWAKGSYLDNYQERNAVDVAKHLMYGAAYLNRVNSLTSQGVKLPTQLLRWKPTQRMA 6lkc A 2.00 BS02 CA A 1 E265 S268 G269 H271 E253 S256 G257 H259 1.3.1.9 SPWPWLVTDTNISFDVTVMEQQLRDFSRGCYVVNHNEKGVGIAQTAELVADQASNSLPVAAFTPALGTESLGDSNFRRVHGVKYAYYAGAMANGISSEELVIALGQAGILCSFGAAGLIPSRVEKAINRIQAALPNGPYMFNLIHSPSEPALERGSVELFLKHKVRTVEASAFLGLTPQIVYYRAAGLSRDAQGNIVVANKVIAKVSRTEVAEKFMMPAPAKMLQKLVDEGSITPEQMELAQLVPMADDITAEADSGGHTDNRPLVTLLPTILALKEEIQTKYQYPTPIRVGCGGGVGTPDAALATFNMGAAYIVTGSVNQACVEAGASEHTRKLLSTTEMADVTMAPAADMFEMGVKLQVVKRGTLFPMRANKLYELYTRYDSIEAIPADEREKLEKQVFRSTLDDIWAGTVAHFNERDPKQIERATDNPKRKMALIFRWYLGLSSRWSNSGETGREMDYQIWAGPALGAFNQWAKGSYLDNYQERNAVDVAKHLMYGAAYLNRVNSLTSQGVKLPTQLLRWKPTQRMA 6lkc B 2.00 BS01 FMN B 1 G101 A102 M103 A104 A128 N154 S183 K217 E265 S268 G269 G307 G308 G329 S330 Q333 W476 A480 G92 A93 M94 A95 A119 N145 S174 K208 E256 S259 G260 G298 G299 G320 S321 Q324 W467 A471 1.3.1.9 LSPWPWLVTDTNISFDVTVMEQQLRDFSRGCYVVNHNEKGVGIAQTAELVADQAANSNSLPVAAFTPALGTESLGDSNFRRVHGVKYAYYAGAMANGISSEELVIALGQAGILCSFGAAGLIPSRVEKAINRIQAALPNGPYMFNLIHSPSEPALERGSVELFLKHKVRTVEASAFLGLTPQIVYYRAAGLSRDAQGNIVVANKVIAKVSRTEVAEKFMMPAPAKMLQKLVDEGSITPEQMELAQLVPMADDITAEADSGGHTDNRPLVTLLPTILALKEEIQTKYQYPTPIRVGCGGGVGTPDAALATFNMGAAYIVTGSVNQACVEAGASEHTRKLLSTTEMADVTMAPAADMFEMGVKLQVVKRGTLFPMRANKLYELYTRYDSIEAIPADEREKLEKQVFRSTLDDIWAGTVAHFNERDPKQIERATDNPKRKMALIFRWYLGLSSRWSNSGETGREMDYQIWAGPALGAFNQWAKGSYLDNYQERNAVDVAKHLMYGAAYLNRVNSLTSQGVKLPTQLLRWKPTQRMA 6lkc B 2.00 BS02 CA B 1 E265 S268 G269 H271 E256 S259 G260 H262 1.3.1.9 LSPWPWLVTDTNISFDVTVMEQQLRDFSRGCYVVNHNEKGVGIAQTAELVADQAANSNSLPVAAFTPALGTESLGDSNFRRVHGVKYAYYAGAMANGISSEELVIALGQAGILCSFGAAGLIPSRVEKAINRIQAALPNGPYMFNLIHSPSEPALERGSVELFLKHKVRTVEASAFLGLTPQIVYYRAAGLSRDAQGNIVVANKVIAKVSRTEVAEKFMMPAPAKMLQKLVDEGSITPEQMELAQLVPMADDITAEADSGGHTDNRPLVTLLPTILALKEEIQTKYQYPTPIRVGCGGGVGTPDAALATFNMGAAYIVTGSVNQACVEAGASEHTRKLLSTTEMADVTMAPAADMFEMGVKLQVVKRGTLFPMRANKLYELYTRYDSIEAIPADEREKLEKQVFRSTLDDIWAGTVAHFNERDPKQIERATDNPKRKMALIFRWYLGLSSRWSNSGETGREMDYQIWAGPALGAFNQWAKGSYLDNYQERNAVDVAKHLMYGAAYLNRVNSLTSQGVKLPTQLLRWKPTQRMA 6lkd A 3.00 BS01 FAD A 1 I14 G15 G17 L18 V19 Y37 E38 A39 R40 S53 L56 A57 R111 H134 L136 C166 D167 G168 T172 Y194 D304 P311 G314 G316 M317 N318 I9 G10 G12 L13 V14 Y32 E33 A34 R35 S43 L46 A47 R101 H124 L126 C150 D151 G152 T156 Y178 D288 P295 G298 G300 M301 N302 1.14.13.9 TEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVARSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCLTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVH 6lkd A 3.00 BS02 EGO A 1 R85 Y99 L213 I215 M222 I224 F238 P311 F312 F313 G314 N363 M367 V371 F376 Q379 R380 Y398 R75 Y89 L197 I199 M206 I208 F222 P295 F296 F297 G298 N347 M351 V355 F360 Q363 R364 Y382 1.14.13.9 TEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVARSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCLTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVH 6lkd B 3.00 BS01 FAD B 1 G15 G17 L18 V19 Y37 E38 A39 R40 S53 L56 A57 R111 H134 K135 L136 C166 D167 G168 T172 Y194 D304 P311 G314 Q315 G316 M317 N318 G10 G12 L13 V14 Y32 E33 A34 R35 S42 L45 A46 R100 H123 K124 L125 C153 D154 G155 T159 Y181 D291 P298 G301 Q302 G303 M304 N305 1.14.13.9 TEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVASINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVA 6lkd B 3.00 BS02 EGO B 1 R85 Y99 L213 I215 I224 F238 P311 F312 F313 G314 N363 M367 F376 R380 Y398 R74 Y88 L200 I202 I211 F225 P298 F299 F300 G301 N350 M354 F363 R367 Y385 1.14.13.9 TEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVASINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVA 6lke A 3.00 BS01 FAD A 1 I14 G15 G17 L18 V19 Y37 E38 A39 R40 L56 A57 R111 H134 K135 L136 C166 D167 G168 T172 Y194 D304 P311 G314 Q315 G316 M317 N318 I9 G10 G12 L13 V14 Y32 E33 A34 R35 L46 A47 R101 H124 K125 L126 C151 D152 G153 T157 Y179 D289 P296 G299 Q300 G301 M302 N303 1.14.13.9 TEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVARSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVH 6lke A 3.00 BS02 EGU A 1 A57 R85 Y99 I106 L213 I215 M222 I224 T236 P311 F312 F313 F376 Y398 A47 R75 Y89 I96 L198 I200 M207 I209 T221 P296 F297 F298 F361 Y383 1.14.13.9 TEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVARSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVH 6lke B 3.00 BS01 FAD B 1 G15 G17 L18 V19 Y37 E38 A39 R40 S53 L56 A57 R111 H134 K135 L136 C166 D167 G168 T172 D304 P311 G314 Q315 G316 M317 N318 G10 G12 L13 V14 Y32 E33 A34 R35 S42 L45 A46 R100 H123 K124 L125 C153 D154 G155 T159 D291 P298 G301 Q302 G303 M304 N305 1.14.13.9 TEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVASINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVA 6lke B 3.00 BS02 EGU B 1 A57 R85 Y99 I106 L213 I215 M222 I224 T236 P311 F312 F313 G314 N363 F376 Y398 A46 R74 Y88 I95 L200 I202 M209 I211 T223 P298 F299 F300 G301 N350 F363 Y385 1.14.13.9 TEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVASINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVA 6lkm A 2.55 BS01 TTP A 1 D226 S227 I228 I231 I255 R256 I262 A263 G264 S269 N270 D152 S153 I154 I157 I181 R182 I188 A189 G190 S195 N196 1.17.4.1 AILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTR 6lkm A 2.55 BS02 EJ6 A 1 I686 S687 Q688 K689 L692 K719 S722 M723 I609 S610 Q611 K612 L615 K642 S645 M646 1.17.4.1 AILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTR 6lkm B 2.55 BS01 TTP B 1 D226 S227 I228 I231 R256 I262 A263 G264 S269 N270 D152 S153 I154 I157 R182 I188 A189 G190 S195 N196 1.17.4.1 AILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTR 6lkm B 2.55 BS02 EJ6 B 1 I686 S687 Q688 K689 K719 M723 Y726 I612 S613 Q614 K615 K645 M649 Y652 1.17.4.1 AILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTR 6lky A 2.20 BS01 NAD A 1 I12 K66 P68 L69 T70 T71 N81 L244 G245 E260 V262 H263 G264 S265 A266 P267 D268 I269 N276 I12 K66 P68 L69 T70 T71 N81 L244 G245 E260 V262 H263 G264 S265 A266 P267 D268 I269 N276 MHKITLIPGDGIGPSIVDAAVKVIEATGVQVQWDTQSAGMAAVEKFGTPLPDATLDSIRANRICFKGPLTTPVGGGYRSVNVTLRQALNLYANVRPAISFEGTDTAFSDVNLVTVRENTEGLYAGIEHFIKVDEEKIAAESIAVVTRKGSERIIRYAFDYARRARRKKVTLVHKANILKCTSGLFLEIGREIAKEYPDIEFDDRIVDACSMQMVMQPQRFDVLVTTNLFGDILSDLAAGLIGGLGLTAGANIGTDAALFEAVHGSAPDIADKGIANPTAMIMAGAMMLEHIGEPDAARRIERAVREVIEDGRSVTPDLAKDSPCGTAQMAEAIVERVRQ 6lky A 2.20 BS02 NAD B 1 N176 I205 N176 I205 MHKITLIPGDGIGPSIVDAAVKVIEATGVQVQWDTQSAGMAAVEKFGTPLPDATLDSIRANRICFKGPLTTPVGGGYRSVNVTLRQALNLYANVRPAISFEGTDTAFSDVNLVTVRENTEGLYAGIEHFIKVDEEKIAAESIAVVTRKGSERIIRYAFDYARRARRKKVTLVHKANILKCTSGLFLEIGREIAKEYPDIEFDDRIVDACSMQMVMQPQRFDVLVTTNLFGDILSDLAAGLIGGLGLTAGANIGTDAALFEAVHGSAPDIADKGIANPTAMIMAGAMMLEHIGEPDAARRIERAVREVIEDGRSVTPDLAKDSPCGTAQMAEAIVERVRQ 6lky B 2.20 BS01 NAD A 1 N176 I205 A208 N176 I205 A208 MHKITLIPGDGIGPSIVDAAVKVIEATGVQVQWDTQSAGMAAVEKFGTPLPDATLDSIRANRICFKGPLTTPVGGGYRSVNVTLRQALNLYANVRPAISFEGTDTAFSDVNLVTVRENTEGLYAGIEHFIKVDEEKIAAESIAVVTRKGSERIIRYAFDYARRARRKKVTLVHKANILKCTSGLFLEIGREIAKEYPDIEFDDRIVDACSMQMVMQPQRFDVLVTTNLFGDILSDLAAGLIGGLGLTAGANIGTDAALFEAVHGSAPDIADKGIANPTAMIMAGAMMLEHIGEPDAARRIERAVREVIEDGRSVTPDLAKDSPCGTAQMAEAIVERVRQ 6lky B 2.20 BS02 NAD B 1 I12 K66 P68 L69 T70 T71 N81 G245 E260 V262 H263 G264 S265 A266 P267 D268 I269 A275 N276 I12 K66 P68 L69 T70 T71 N81 G245 E260 V262 H263 G264 S265 A266 P267 D268 I269 A275 N276 MHKITLIPGDGIGPSIVDAAVKVIEATGVQVQWDTQSAGMAAVEKFGTPLPDATLDSIRANRICFKGPLTTPVGGGYRSVNVTLRQALNLYANVRPAISFEGTDTAFSDVNLVTVRENTEGLYAGIEHFIKVDEEKIAAESIAVVTRKGSERIIRYAFDYARRARRKKVTLVHKANILKCTSGLFLEIGREIAKEYPDIEFDDRIVDACSMQMVMQPQRFDVLVTTNLFGDILSDLAAGLIGGLGLTAGANIGTDAALFEAVHGSAPDIADKGIANPTAMIMAGAMMLEHIGEPDAARRIERAVREVIEDGRSVTPDLAKDSPCGTAQMAEAIVERVRQ 6lnr A 1.66 BS01 MG A 1 P79 F138 K139 E140 P79 F138 K139 E140 32750481 EQCSAIVPCPGGRCCSQWGYCGNTPAYCCTGCQSNCEETVCGDCPPNSGSAGDGGENGKIISRDMFDELLKRRNDLDCPARCFYTYNDFIQAAKAFPAFGDTGNDVIRKREIAAFFAQTSHETTGGSPGGPYQKGYCFKEEVGPGGGYCGGGYPCPDPGQYYGRGPIQLTWNYNYIFCGDDINQDLDNHPNLNSVNGVLSFKSAIWFWMTPQSPKPSCHDVMTNEWAPGGADGNAGRDPGFGLTTNIINGGLECGFGTDSRVQDRIGYFKHFCSNFGIDPGNNLDCYTQTPY 6loj B 3.72 BS01 GDP B 1 Y47 R48 G50 K51 S52 E99 G100 D184 A248 Y45 R46 G48 K49 S50 E97 G98 D174 A234 3.6.5.- SEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDSADFVSFFPDFVWTLRDFSLDLEALTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLHEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRR 6lxn A 2.93 BS01 NUC C 1 T28 G30 R58 E64 S66 V69 R73 W92 T27 G29 R57 E63 S65 V68 R72 W91 33152421 AVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKALEHHHH 6lxn A 2.93 BS02 NUC D 1 R48 R65 D68 S72 R75 R76 T90 W92 G93 Y96 R47 R64 D67 S71 R74 R75 T89 W91 G92 Y95 33152421 AVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKALEHHHH 6lxn B 2.93 BS01 NUC C 1 T28 G30 R56 R58 E64 R65 S66 V69 W92 T27 G29 R55 R57 E63 R64 S65 V68 W91 33152421 AVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDG 6lxn B 2.93 BS02 NUC D 1 R48 R65 D68 S72 R75 R76 T90 W92 G93 Y96 R47 R64 D67 S71 R74 R75 T89 W91 G92 Y95 33152421 AVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDG 6lyy A 3.60 BS01 EY0 A 1 Y34 K38 L66 Y70 M151 S154 P155 L158 F278 L281 L305 D309 R313 F367 S371 Y21 K25 L53 Y57 M138 S141 P142 L145 F211 L214 L238 D242 R246 F300 S304 PDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLA 6pe6 A 1.60 BS01 ODG A 1 E138 V194 R207 G210 T211 E121 V177 R190 G193 T194 2.7.1.33 SPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNF 6pe6 A 1.60 BS02 ANP A 1 G19 G20 T21 L22 K24 G191 S192 G215 G216 F231 G321 N322 F323 R325 G9 G10 T11 L12 K14 G174 S175 G198 G199 F214 G304 N305 F306 R308 2.7.1.33 SPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNF 6t13 A 1.85 BS01 M7H D 1 P245 F246 Q284 Y313 L314 S345 N396 P245 F246 Q284 Y313 L314 S345 N396 3.2.1.45 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ 6t13 B 1.85 BS01 M7H C 1 P245 F246 Q284 Y313 L314 S345 V394 N396 P245 F246 Q284 Y313 L314 S345 V394 N396 3.2.1.45 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ 6t13 C 1.85 BS01 M7H C 1 S345 W348 E349 S345 W348 E349 3.2.1.45 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ 6t13 D 1.85 BS01 M7H D 1 S345 W348 E349 S342 W345 E346 3.2.1.45 ARPCIPKSFGYSSVVCVCNATYCDSFDFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ 6tp5 A 2.25 BS01 FE2 A 1 H328 D330 H441 H217 D219 H330 1.14.11.29 TLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREG 6tp5 A 2.25 BS02 CA A 1 D198 N200 D202 H204 Q206 E209 D87 N89 D91 H93 Q95 E98 1.14.11.29 TLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREG 6tp5 A 2.25 BS03 CA A 2 D237 D239 D241 V243 E248 D126 D128 D130 V132 E137 1.14.11.29 TLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREG 6tp5 B 2.25 BS01 FE2 B 1 H328 D330 H441 H210 D212 H316 1.14.11.29 LGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREG 6tp5 B 2.25 BS02 CA B 1 D198 N200 D202 H204 Q206 E209 D80 N82 D84 H86 Q88 E91 1.14.11.29 LGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREG 6tp5 B 2.25 BS03 CA B 2 D237 D239 D241 V243 E248 D119 D121 D123 V125 E130 1.14.11.29 LGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREG 6v6u A 1.16 BS01 GDP A 1 A15 C16 G17 K18 T19 C20 K118 D120 L121 S160 A161 K162 A13 C14 G15 K16 T17 C18 K116 D118 L119 S158 A159 K160 3.6.5.2 AIRKKLVIVGDGACGKTCLLIVNSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQA 6v6u A 1.16 BS02 MG A 1 T19 P36 T17 P34 3.6.5.2 AIRKKLVIVGDGACGKTCLLIVNSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQA 6v6v A 1.40 BS01 GDP A 1 A15 C16 G17 K18 T19 C20 K118 D120 L121 S160 A161 K162 A13 C14 G15 K16 T17 C18 K116 D118 L119 S158 A159 K160 3.6.5.2 AIRKKLVIVGDVACGKTCLLIVNSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQA 6v6v A 1.40 BS02 MG A 1 T19 P36 T17 P34 3.6.5.2 AIRKKLVIVGDVACGKTCLLIVNSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQA 6vb8 A 2.20 BS01 CA A 1 D10 Y12 N14 D19 D10 Y12 N14 D19 ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNTNALHFMFNQFSKDQKDLILQGDATTGTEGNLRLTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFEATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDAN 6vb8 A 2.20 BS02 MN A 1 E8 D10 D19 H24 E8 D10 D19 H24 ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNTNALHFMFNQFSKDQKDLILQGDATTGTEGNLRLTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFEATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDAN 6vb8 A 2.20 BS03 DBB A 1 S113 N124 A125 L126 V179 H180 S113 N120 A121 L122 V175 H176 ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNTNALHFMFNQFSKDQKDLILQGDATTGTEGNLRLTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFEATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDAN 6vb8 A 2.20 BS04 IAC A 1 T49 S108 N131 T49 S108 N127 ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNTNALHFMFNQFSKDQKDLILQGDATTGTEGNLRLTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFEATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDAN 6vc2 A 1.70 BS01 III C 1 F354 R361 V371 D372 Q374 M375 Q379 L531 E534 M535 F55 R62 V72 D73 Q75 M76 Q80 L229 E232 M233 SIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVNLLIEMLHA 6vc2 A 1.70 BS02 QU7 A 1 F342 M345 C346 M348 A349 S383 L386 I387 H390 L405 L424 L427 A431 A513 L517 F43 M46 C47 M49 A50 S84 L87 I88 H91 L106 L125 L128 A132 A214 L218 SIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVNLLIEMLHA 6vc6 A 2.13 BS01 MN A 1 C170 H200 C162 H191 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 A 2.13 BS02 G6P A 1 R93 E109 N147 C170 D171 Q172 H200 W241 Y263 R283 R291 R87 E103 N139 C162 D163 Q164 H191 W232 Y252 R272 R280 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 A 2.13 BS03 NAD A 1 G12 S13 T14 Y15 D39 I40 D41 R44 Q84 R86 E109 Y118 D125 Y145 N147 I169 C170 D171 R291 H319 G11 S12 T13 Y14 D37 I38 D39 R42 Q80 R81 E103 Y111 D118 Y137 N139 I161 C162 D163 R280 H300 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 B 2.13 BS01 MN B 1 C170 H200 C162 H191 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELGDRFDTISDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 B 2.13 BS02 G6P B 1 R93 E109 N147 C170 D171 H200 W241 Y263 R283 V287 R291 R87 E103 N139 C162 D163 H191 W232 Y252 R272 V276 R280 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELGDRFDTISDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 B 2.13 BS03 NAD B 1 G12 S13 T14 Y15 D39 I40 D41 R44 Q84 R86 E109 Y118 D125 Y145 N147 I169 C170 D171 R291 H319 G11 S12 T13 Y14 D37 I38 D39 R42 Q80 R81 E103 Y111 D118 Y137 N139 I161 C162 D163 R280 H308 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELGDRFDTISDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 C 2.13 BS01 MN C 1 C170 H200 C162 H191 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELGDRFDSDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 C 2.13 BS02 G6P C 1 R93 E109 N147 C170 D171 Q172 H200 W241 Y263 R283 R291 R87 E103 N139 C162 D163 Q164 H191 W232 Y252 R272 R280 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELGDRFDSDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 C 2.13 BS03 NAD C 1 G12 S13 T14 Y15 D39 I40 D41 R44 Q84 R86 E109 Y118 D125 Y145 N147 I169 C170 D171 R291 H319 G11 S12 T13 Y14 D37 I38 D39 R42 Q80 R81 E103 Y111 D118 Y137 N139 I161 C162 D163 R280 H306 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELGDRFDSDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 D 2.13 BS01 MN D 1 C170 H200 C162 H191 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELGDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 D 2.13 BS02 G6P D 1 R93 E109 N147 C170 D171 Q172 H200 W241 Y263 R283 V287 R291 R87 E103 N139 C162 D163 Q164 H191 W232 Y252 R272 V276 R280 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELGDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vc6 D 2.13 BS03 NAD D 1 G12 S13 T14 Y15 D39 I40 D41 R44 Q84 R86 E109 Y118 D125 Y145 N147 I169 C170 D171 R291 H319 G11 S12 T13 Y14 D37 I38 D39 R42 Q80 R81 E103 Y111 D118 Y137 N139 I161 C162 D163 R280 H301 3.2.1.122 KKYNVCIVGGGSTYTPGFLKSFVRLQNEFPEKLVLFDIDAERQQPIGEFGKILFSERFPELDFSYTTDPAEAYKDDFIFQRAGGLPRREDEHISLHLGRIGQETCGAGGAYGLRSCVDIESIHQIRQYSPNAWILNYSNPAAIVAEALRREFPDDNRILNICDQPENIRSVSRLLNVSWEDLDPVYFGLNHYGWFTHVYDRKTGEDLLPEIKKIIKEKGFLPQDAEQRDQSWLDTYGFVQTEDFPDFLPNTYDGYYLYPDYKFSHLNPDYTRADEVIDGREKRVFAECREVIARGELGDAHAEIKVAEAIAYNKNTRFIVIVKNEGAIANQDDAVELVCELGINGPRRAVGNIPQFYLGLLVQQVSSEKLLVDAYYEHSYQKALEAFTLNRLINDAKKAREILDAIEVNKGWPELK 6vd3 A 1.67 BS01 MH0 A 1 F24 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 L100 F101 F24 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 L100 F101 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd3 A 1.67 BS02 BML A 1 F21 F35 H55 T56 V59 L100 F21 F35 H55 T56 V59 L100 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd3 B 1.67 BS01 MH0 B 1 F24 E31 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 F24 E31 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd3 B 1.67 BS02 BML B 1 F21 F35 H55 T56 V59 L100 F21 F35 H55 T56 V59 L100 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd4 A 1.95 BS01 MH0 A 1 F24 E31 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 L127 F24 E31 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 L127 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd4 A 1.95 BS02 MWJ A 1 F21 F35 H55 T56 V59 L100 F21 F35 H55 T56 V59 L100 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd4 B 1.95 BS01 MH0 B 1 E31 N34 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 E31 N34 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd4 B 1.95 BS02 MWJ B 1 F21 F35 H55 T56 V59 F60 L100 F21 F35 H55 T56 V59 F60 L100 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd5 A 1.64 BS01 MH0 A 1 F24 F35 H55 V59 L62 L83 M86 L92 N96 F97 L100 F24 F35 H55 V59 L62 L83 M86 L88 N92 F93 L96 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd5 A 1.64 BS02 T6C A 1 F21 F35 Y38 F52 H55 T56 V59 F21 F35 Y38 F52 H55 T56 V59 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd5 B 1.64 BS01 T6C B 1 F21 F35 Y38 F52 H55 T56 V59 F21 F35 Y38 F52 H55 T56 V59 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd5 B 1.64 BS02 MH0 B 1 F24 F35 V59 L62 L83 M86 L92 N96 F97 L100 F24 F35 V59 L62 L83 M86 L87 N91 F92 L95 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd6 A 1.56 BS01 MH0 A 1 F24 F35 H55 K58 V59 M63 L83 M86 Q88 H89 L92 N96 F97 L127 F24 F35 H55 K58 V59 M63 L83 M86 Q88 H89 L92 N96 F97 L127 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd6 A 1.56 BS02 NPO A 1 F21 F35 Y38 H55 T56 V59 F60 L100 F21 F35 Y38 H55 T56 V59 F60 L100 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd6 B 1.56 BS01 MH0 B 1 F24 E31 N34 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 L100 F24 E31 N34 F35 H55 K58 V59 L62 M63 L83 M86 Q88 H89 L92 N96 F97 L100 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vd6 B 1.56 BS02 NPO B 1 F21 F35 H55 T56 V59 L100 F21 F35 H55 T56 V59 L100 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 6vjk A 1.60 BS01 BTN A 1 N23 L25 S27 Y43 S45 V47 C49 A50 W79 S88 T90 W92 W108 L110 D128 N9 L11 S13 Y29 S31 V33 C35 A36 W65 S74 T76 W78 W94 L96 D114 32719366 AGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPS 6vjk B 1.60 BS01 BTN B 1 N23 L25 S27 Y43 S45 V47 G48 C49 A50 W79 S88 T90 W92 W108 L110 D128 N9 L11 S13 Y29 S31 V33 G34 C35 A36 W65 S74 T76 W78 W94 L96 D114 32719366 AGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTK 6vjk C 1.60 BS01 BTN C 1 N23 L25 S27 Y43 S45 V47 G48 C49 A50 W79 S88 T90 W92 W108 L110 D128 N9 L11 S13 Y29 S31 V33 G34 C35 A36 W65 S74 T76 W78 W94 L96 D114 32719366 AGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVK 6vjk D 1.60 BS01 BTN D 1 N23 L25 S27 Y43 S45 V47 C49 A50 W79 S88 T90 W92 W108 L110 D128 N10 L12 S14 Y30 S32 V34 C36 A37 W66 S75 T77 W79 W95 L97 D115 32719366 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPS 6vjk E 1.60 BS01 BTN E 1 N23 L25 S27 Y43 S45 V47 G48 C49 A50 W79 S88 T90 W92 W108 L110 D128 N8 L10 S12 Y28 S30 V32 G33 C34 A35 W64 S73 T75 W77 W93 L95 D113 32719366 GITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPS 6vjk F 1.60 BS01 BTN F 1 N23 L25 S27 Y43 S45 V47 G48 C49 A50 W79 S88 T90 W92 W108 L110 D128 N10 L12 S14 Y30 S32 V34 G35 C36 A37 W66 S75 T77 W79 W95 L97 D115 32719366 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPS 6vjk G 1.60 BS01 BTN G 1 N23 L25 S27 Y43 S45 V47 G48 C49 A50 W79 S88 T90 W92 W108 L110 D128 N10 L12 S14 Y30 S32 V34 G35 C36 A37 W66 S75 T77 W79 W95 L97 D115 32719366 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPS 6vjk H 1.60 BS01 BTN H 1 N23 L25 S27 Y43 S45 V47 G48 C49 A50 W79 S88 T90 W92 W108 L110 D128 N10 L12 S14 Y30 S32 V34 G35 C36 A37 W66 S75 T77 W79 W95 L97 D115 32719366 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPS 6vjk I 1.60 BS01 BTN I 1 N23 L25 S27 Y43 S45 V47 G48 C49 A50 W79 S88 T90 W92 W108 L110 D128 N9 L11 S13 Y29 S31 V33 G34 C35 A36 W65 S74 T76 W78 W94 L96 D114 32719366 AGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKP 6vjk J 1.60 BS01 BTN J 1 N23 L25 S27 Y43 S45 V47 G48 C49 A50 W79 S88 T90 W92 W108 L110 D128 N8 L10 S12 Y28 S30 V32 G33 C34 A35 W64 S73 T75 W77 W93 L95 D113 32719366 GITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVK 6vjk K 1.60 BS01 BTN K 1 N23 L25 S27 Y43 S45 V47 C49 A50 W79 S88 T90 W92 W108 L110 D128 N9 L11 S13 Y29 S31 V33 C35 A36 W65 S74 T76 W78 W94 L96 D114 32719366 AGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVK 6vjk L 1.60 BS01 BTN L 1 N23 L25 S27 Y43 S45 V47 G48 C49 A50 W79 S88 T90 W92 W108 L110 D128 N9 L11 S13 Y29 S31 V33 G34 C35 A36 W65 S74 T76 W78 W94 L96 D114 32719366 AGITGTWYNQLGSTFIVTAGADGALTGTYESAVGCAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNCHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 6vjl A 1.30 BS01 BTN A 1 S27 Y43 S45 V47 G48 N49 W79 S88 T90 W92 W108 L110 D128 S16 Y32 S34 V36 G37 N38 W68 S77 T79 W81 W97 L99 D117 32719366 AAEAGITGTWYNQLCSTFIVTAGADGALTGTYESCVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVK 6vsp A 1.90 BS01 NAD A 1 G12 N15 G16 M17 D36 W37 I59 D60 V61 N87 A88 G89 V90 V110 T136 A137 S138 Y151 K155 P181 S182 L183 V184 T186 N187 M188 T189 G12 N15 G16 M17 D36 W37 I59 D60 V61 N87 A88 G89 V90 V110 T136 A137 S138 Y151 K155 P181 S182 L183 V184 T186 N187 M188 T189 1.1.1.- 33292448 GRFDNKVVVITGAGNGMGEAAARRFSAEGAIVVLADWAKEAVDKVAASLPKGRAMAVHIDVSDHVAVEKMMNEVAEKLGRIDVLLNNAGVHVAGSVLETSIDDWRRIAGVDIDGVVFCSKFALPHLLKTKGCIVNTASVSGLGGDWGAAYYCAAKGAVVNLTRAMALDHGGDGVRINSVCPSLVKTNMTNGWPQEIRDKFNERIALGRAAEPEEVAAVMAFLASDDASFINGANIPVDGGATASDGAPKIV 6vsp A 1.90 BS02 NAD A 2 W37 A38 N187 N190 W37 A38 N187 N190 1.1.1.- 33292448 GRFDNKVVVITGAGNGMGEAAARRFSAEGAIVVLADWAKEAVDKVAASLPKGRAMAVHIDVSDHVAVEKMMNEVAEKLGRIDVLLNNAGVHVAGSVLETSIDDWRRIAGVDIDGVVFCSKFALPHLLKTKGCIVNTASVSGLGGDWGAAYYCAAKGAVVNLTRAMALDHGGDGVRINSVCPSLVKTNMTNGWPQEIRDKFNERIALGRAAEPEEVAAVMAFLASDDASFINGANIPVDGGATASDGAPKIV 6vsp B 1.90 BS01 ADP B 1 G12 G14 N15 D36 W37 I59 D60 V61 A88 G89 G14 G16 N17 D38 W39 I61 D62 V63 A90 G91 1.1.1.- 33292448 FQGRFDNKVVVITGAGNGMGEAAARRFSAEGAIVVLADWAKEAVDKVAASLPKGRAMAVHIDVSDHVAVEKMMNEVAEKLGRIDVLLNNAGVHVAGSVLETSIDDWRRIAGVDIDGVVFCSKFALPHLLKTKGCIVNTASVSGLGGDWGAAYYCAAKGAVVNLTRAMALDHGGDGVRINSVCPSLVKTNMTNGWPQEIRDKFNERIALGRAAEPEEVAAVMAFLASDDASFINGANIPVDGGATASDGAPKI 6w9g C 1.82 BS01 TMO C 1 C178 C218 Q220 C60 C96 Q98 32845612 NPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNRQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL 6w9g H 1.82 BS01 TMO H 1 Q39 Y95 Q39 Y95 32845612 QVQLVQSGAEVVKPGASVKLSCKASGYIFTSYYMYWVKQAPGQGLEWIGEINPSNGDTNFNEKFKSKATLTVDKSASTAYMELSSLRSEDTAVYYCTRSDGRNDMDSWGQGTLVTVSSASTKGPSVFPLAPGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 6w9g H 1.82 BS02 TMO H 2 V2 S107 V2 S107 32845612 QVQLVQSGAEVVKPGASVKLSCKASGYIFTSYYMYWVKQAPGQGLEWIGEINPSNGDTNFNEKFKSKATLTVDKSASTAYMELSSLRSEDTAVYYCTRSDGRNDMDSWGQGTLVTVSSASTKGPSVFPLAPGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 6w9g L 1.82 BS01 TMO H 1 Q42 P44 G45 Q46 Q42 P44 G45 Q46 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 6w9g L 1.82 BS02 TMO L 1 S31 S32 T33 Y34 S35 S31 S32 T33 Y34 S35 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 6w9g L 1.82 BS03 TMO L 2 T5 S7 T5 S7 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 6w9g K 1.82 BS01 TMO K 1 Q39 Y95 Q39 Y95 32845612 QVQLVQSGAEVVKPGASVKLSCKASGYIFTSYYMYWVKQAPGQGLEWIGEINPSNGDTNFNEKFKSKATLTVDKSASTAYMELSSLRSEDTAVYYCTRSDGRNDMDSWGQGTLVTVSSASTKGPSVFPLAPGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 6w9g K 1.82 BS02 TMO K 2 Q110 G111 Q110 G111 32845612 QVQLVQSGAEVVKPGASVKLSCKASGYIFTSYYMYWVKQAPGQGLEWIGEINPSNGDTNFNEKFKSKATLTVDKSASTAYMELSSLRSEDTAVYYCTRSDGRNDMDSWGQGTLVTVSSASTKGPSVFPLAPGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 6w9g K 1.82 BS03 TMO K 3 V2 S107 V2 S107 32845612 QVQLVQSGAEVVKPGASVKLSCKASGYIFTSYYMYWVKQAPGQGLEWIGEINPSNGDTNFNEKFKSKATLTVDKSASTAYMELSSLRSEDTAVYYCTRSDGRNDMDSWGQGTLVTVSSASTKGPSVFPLAPGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 6w9g M 1.82 BS01 TMO K 1 Q42 G45 Q42 G45 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG 6w9g M 1.82 BS02 TMO M 1 S31 S32 T33 Y34 S35 S31 S32 T33 Y34 S35 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG 6w9g M 1.82 BS03 TMO M 2 Y34 Y54 Y34 Y54 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG 6w9g M 1.82 BS04 TMO M 3 I110 Q170 I109 Q169 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG 6w9g X 1.82 BS01 TMO X 1 Q39 Y95 Q39 Y94 32845612 QVQLVQSGAEVVKPGASVKLSCKASGYIFTSYYMYWVKQAPGGLEWIGEINPSNGDTNFNEKFKSKATLTVDKSASTAYMELSSLRSEDTAVYYCTRSDGRNDMDSWGQGTLVTVSSASTKGPSVFPLAPGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 6w9g X 1.82 BS02 TMO X 2 Q110 G111 Q109 G110 32845612 QVQLVQSGAEVVKPGASVKLSCKASGYIFTSYYMYWVKQAPGGLEWIGEINPSNGDTNFNEKFKSKATLTVDKSASTAYMELSSLRSEDTAVYYCTRSDGRNDMDSWGQGTLVTVSSASTKGPSVFPLAPGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 6w9g Y 1.82 BS01 TMO X 1 Q42 P44 G45 Q42 P44 G45 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG 6w9g Y 1.82 BS02 TMO Y 1 S32 T33 Y34 S35 S32 T33 Y34 S35 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG 6w9g Y 1.82 BS03 TMO Y 2 Y34 Y54 Y34 Y54 32845612 DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG 6w9n A BS01 ZN A 1 C20 C23 C44 C47 C20 C23 C44 C47 33225481 SNAGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERG 6w9n A BS02 ZN A 2 C36 C39 C66 C69 C36 C39 C66 C69 33225481 SNAGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERG 6wl2 A 3.30 BS01 III B 1 Y7 V9 R62 E63 K66 N70 S73 D77 L81 Y84 V97 S99 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 Y7 V9 R62 E63 K66 N70 S73 D77 L81 Y84 V97 S99 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQECPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGQDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNAT 6wl2 C 3.30 BS01 III B 1 Q48 R55 W97 Q47 R54 W96 SGVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPCRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVVEDLRNVTPPKVSLREPSKAEIANKQKATLQCQARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRAD 6wl2 D 3.30 BS01 III E 1 L5 Y7 V9 E63 K66 N70 S73 F74 D77 S99 Q114 Y116 T143 K146 W147 E152 R155 L156 Y159 T163 W167 Y171 L4 Y6 V8 E62 K65 N69 S72 F73 D76 S98 Q113 Y115 T142 K145 W146 E151 R154 L155 Y158 T162 W166 Y170 PHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQECPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGQDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNA 6wl2 F 3.30 BS01 III E 1 Q48 R55 W97 Q46 R53 W95 GVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPCRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVVEDLRNVTPPKVSLREPSKAEIANKQKATLQCQARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADS 6wl2 G 3.30 BS01 III H 1 Y7 E63 N70 S73 F74 D77 L81 Y84 V97 S99 Q114 Y123 T143 W147 E152 R155 L156 Y159 W167 Y171 Y7 E63 N70 S73 F74 D77 L81 Y84 V97 S99 Q114 Y123 T143 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQECPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGQDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNA 6wl2 I 3.30 BS01 III H 1 Q48 R55 W97 Q48 R55 W97 DSGVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPCRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVVEDLRNVTPPKVSLREPSKAEIANKQKATLQCQARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGR 6wl3 A 3.45 BS01 III B 1 Y7 V9 R62 E63 K66 N70 F74 D77 L81 Y84 V97 S99 Y116 Y123 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 Y7 V9 R62 E63 K66 N70 F74 D77 L81 Y84 V97 S99 Y116 Y123 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQECPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGQDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNATL 6wl3 C 3.45 BS01 III B 1 R55 W97 R54 W96 SGVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPCRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVVEDLRNVTPPKVSLREPSKAEIANKQKATLQCQARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRAD 6wl3 D 3.45 BS01 III E 1 L5 Y7 V9 R62 E63 K66 N70 S73 F74 D77 L81 Y84 S99 Q114 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 L5 Y7 V9 R62 E63 K66 N70 S73 F74 D77 L81 Y84 S99 Q114 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQECPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGQDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNA 6wl3 F 3.45 BS01 III E 1 Q48 R55 W97 Q47 R54 W96 SGVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPCRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVVEDLRNVTPPKVSLREPSKAEIANKQKATLQCQARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADS 6wl3 G 3.45 BS01 III H 1 Y7 E63 N70 S73 F74 D77 L81 Y84 V97 S99 Y116 T143 W147 E152 R155 L156 Y159 W167 Y171 Y7 E63 N70 S73 F74 D77 L81 Y84 V97 S99 Y116 T143 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQECPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGQDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNA 6wl3 I 3.45 BS01 III H 1 R55 W97 R54 W96 SGVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPCRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVVEDLRNVTPPKVSLREPSKAEIANKQKATLQCQARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGR 6wl4 A 3.60 BS01 III B 1 Y7 V9 C62 E63 K66 N70 D77 L81 V97 S99 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 Y7 V9 C62 E63 K66 N70 D77 L81 V97 S99 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWECETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGQDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNAT 6wl4 C 3.60 BS01 III B 1 Q48 W97 Q47 W96 SGVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPCRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVVEDLRNVTPPKVSLREPSKAEIANKQKATLQCQARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRAD 6wl4 D 3.60 BS01 III E 1 Y7 V9 C62 E63 K66 N70 S73 F74 D77 V97 S99 Q114 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 Y7 V9 C62 E63 K66 N70 S73 F74 D77 V97 S99 Q114 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWECETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGQDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNA 6wl4 F 3.60 BS01 III E 1 Q48 R55 W97 Q47 R54 W96 SGVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPCRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVVEDLRNVTPPKVSLREPSKAEIANKQKATLQCQARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADS 6wl4 G 3.60 BS01 III H 1 Y7 Y59 C62 E63 N70 S73 F74 D77 L81 Y84 V97 S99 Q114 Y123 T143 W147 E152 R155 L156 Y159 W167 Y171 Y7 Y59 C62 E63 N70 S73 F74 D77 L81 Y84 V97 S99 Q114 Y123 T143 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWECETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGQDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNA 6wl4 I 3.60 BS01 III H 1 R55 W97 R55 W97 DSGVVQSPRHIIKEKGGRSVLTCIPISGHSNVVWYQQTLGKELKFLIQHYEKVERDKGFLPCRFSVQQFDDYHSEMNMSALELEDSAMYFCASSLRWGDEQYFGPGTRLTVVEDLRNVTPPKVSLREPSKAEIANKQKATLQCQARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRAD 6wma A 2.50 BS01 NUC B 1 W211 V212 R213 G214 R215 H216 Y315 D316 W194 V195 R196 G197 R198 H199 Y294 D295 33098858 GPLGSMDPDTFSDNFNNRPIASRRNTVYLCYEVKTKGPSRDAKIFRGQAASEDKYHPEMRFLSLVSKWRDQEYEVTWYISWSPCTKCARDMATFLQENTHVTLTIFVARLYAAADPDYQEALRSLAQAGATIKIMNYDEFQHCWSKFVYSQGAPFQPWDGLDEHSQALSGRLGEILRHSMDAATFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLAQRRGFLANQAKHLEGRHAALCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYDDKGRAAEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQNQ 6wma A 2.50 BS02 ZN A 1 H257 C288 C291 H236 C267 C270 33098858 GPLGSMDPDTFSDNFNNRPIASRRNTVYLCYEVKTKGPSRDAKIFRGQAASEDKYHPEMRFLSLVSKWRDQEYEVTWYISWSPCTKCARDMATFLQENTHVTLTIFVARLYAAADPDYQEALRSLAQAGATIKIMNYDEFQHCWSKFVYSQGAPFQPWDGLDEHSQALSGRLGEILRHSMDAATFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLAQRRGFLANQAKHLEGRHAALCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYDDKGRAAEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQNQ 6wmb A 3.02 BS01 NUC B 1 W211 V212 R213 R215 H216 W285 Y315 D316 W194 V195 R196 R198 H199 W263 Y293 D294 33098858 GPLGSMDPDTFSDNFNNRPIASRRNTVYLCYEVKTKGPSRDAKIFRGQAASEDKYHPEMRFLSLVSKWRDQEYEVTWYISWSPCTKCARDMATFLQENTHVTLTIFVARLYAAADPDYQEALRSLAQAGATIKIMNYDEFQHCWSKFVYSQGAPFQPWDGLDEHSQALSGRLGEILRHSMDAATFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLAQRRGFLANQAKLEGRHAALCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYDDKGRAAEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQNQ 6wmb A 3.02 BS02 ZN A 1 H257 C288 C291 H235 C266 C269 33098858 GPLGSMDPDTFSDNFNNRPIASRRNTVYLCYEVKTKGPSRDAKIFRGQAASEDKYHPEMRFLSLVSKWRDQEYEVTWYISWSPCTKCARDMATFLQENTHVTLTIFVARLYAAADPDYQEALRSLAQAGATIKIMNYDEFQHCWSKFVYSQGAPFQPWDGLDEHSQALSGRLGEILRHSMDAATFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLAQRRGFLANQAKLEGRHAALCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYDDKGRAAEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQNQ 6wmc A 3.49 BS01 NUC B 1 W211 V212 R213 G214 H216 Y315 D316 W194 V195 R196 G197 H199 Y295 D296 33098858 GPLGSMDPDTFSDNFNNRPIASRRNTVYLCYEVKTKGPSRDAKIFRGQAASEDKYHPEMRFLSLVSKWRDQEYEVTWYISWSPCTKCARDMATFLQENTHVTLTIFVARLYAAADPDYQEALRSLAQAGATIKIMNYDEFQHCWSKFVYSQGAPFQPWDGLDEHSQALSGRLGEILRHSMDAATFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLAQRRGFLANQAKHKLEGRHAALCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYDDKGRAAEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQNQ 6wmc A 3.49 BS02 ZN A 1 H257 C288 C291 H237 C268 C271 33098858 GPLGSMDPDTFSDNFNNRPIASRRNTVYLCYEVKTKGPSRDAKIFRGQAASEDKYHPEMRFLSLVSKWRDQEYEVTWYISWSPCTKCARDMATFLQENTHVTLTIFVARLYAAADPDYQEALRSLAQAGATIKIMNYDEFQHCWSKFVYSQGAPFQPWDGLDEHSQALSGRLGEILRHSMDAATFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLAQRRGFLANQAKHKLEGRHAALCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYDDKGRAAEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQNQ 6wte A 1.67 BS01 SF4 A 1 C227 Y229 C231 H233 C234 P237 S272 E273 L276 Q310 Y354 C227 Y229 C231 H233 C234 P237 S272 E273 L276 Q310 Y354 MSRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPAVLTVRHGKTQPAEPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPDPARAADPEERWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKAREAAAQ 6wte A 1.67 BS02 B12 A 1 N11 V13 I17 A21 V24 L25 G65 V66 T67 R69 N70 T71 T73 V74 Y75 V102 G104 G105 I106 V125 G127 P128 G129 E130 L218 S220 E236 K240 T270 D271 F414 N11 V13 I17 A21 V24 L25 G65 V66 T67 R69 N70 T71 T73 V74 Y75 V102 G104 G105 I106 V125 G127 P128 G129 E130 L218 S220 E236 K240 T270 D271 F414 MSRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPAVLTVRHGKTQPAEPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPDPARAADPEERWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKAREAAAQ 6wte B 1.67 BS01 SF4 B 1 C227 Y229 C231 H233 C234 P237 S272 E273 L276 Q310 Y354 C216 Y218 C220 H222 C223 P226 S261 E262 L265 Q299 Y343 MSRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPPAEPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLWHGAVADLWALIDPADHHRVMLPTVNPFLTSLGGLGYTGAFWSHWRGREEIMRKAREAA 6wte B 1.67 BS02 B12 B 1 N11 V13 I17 A21 V24 L25 G65 V66 T67 R69 N70 T71 T73 V74 Y75 V102 G104 G105 I106 G107 V125 G127 P128 G129 E130 L218 S220 E236 K240 T270 F414 N11 V13 I17 A21 V24 L25 G65 V66 T67 R69 N70 T71 T73 V74 Y75 V102 G104 G105 I106 G107 V125 G127 P128 G129 E130 L207 S209 E225 K229 T259 F403 MSRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPPAEPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLWHGAVADLWALIDPADHHRVMLPTVNPFLTSLGGLGYTGAFWSHWRGREEIMRKAREAA 6wtf A 2.19 BS01 SF4 A 1 C227 C231 H233 C234 E236 P237 S272 E273 L276 Q310 Y354 C214 C218 H220 C221 E223 P224 S259 E260 L263 Q297 Y341 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPAEPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKAREAAA 6wtf A 2.19 BS02 B12 A 1 N11 V13 I17 Y20 A21 V24 L25 G65 V66 T67 R69 N70 T71 T73 V74 V102 G104 G105 I106 G107 V125 G127 P128 G129 E130 L218 G219 S220 C234 E236 K240 H268 T269 T270 D271 Y308 F414 N528 Y529 A530 F547 N10 V12 I16 Y19 A20 V23 L24 G64 V65 T66 R68 N69 T70 T72 V73 V101 G103 G104 I105 G106 V124 G126 P127 G128 E129 L205 G206 S207 C221 E223 K227 H255 T256 T257 D258 Y295 F401 N504 Y505 A506 F523 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPAEPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKAREAAA 6wtf A 2.19 BS03 SA8 A 1 V74 H233 E236 S272 E273 Y308 D335 E377 L411 R412 V73 H220 E223 S259 E260 Y295 D322 E364 L398 R399 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPAEPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKAREAAA 6wtf A 2.19 BS04 TRP A 1 V74 Y308 N331 M375 E377 N527 Y529 V73 Y295 N318 M362 E364 N503 Y505 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPAEPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKAREAAA 6wtf B 2.19 BS01 SF4 B 1 C227 Y229 C231 H233 C234 E236 P237 S272 E273 L276 Q310 Y354 C212 Y214 C216 H218 C219 E221 P222 S257 E258 L261 Q295 Y339 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPERWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKARE 6wtf B 2.19 BS02 B12 B 1 N11 V13 I17 Y20 A21 V24 L25 G65 V66 T67 R69 N70 T71 T73 V74 V102 G104 G105 I106 G107 V125 G127 P128 G129 E130 L218 G219 S220 C234 E236 K240 T270 S272 Y308 F414 N528 Y529 A530 F547 N10 V12 I16 Y19 A20 V23 L24 G64 V65 T66 R68 N69 T70 T72 V73 V101 G103 G104 I105 G106 V124 G126 P127 G128 E129 L203 G204 S205 C219 E221 K225 T255 S257 Y293 F399 N504 Y505 A506 F523 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPERWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKARE 6wtf B 2.19 BS03 SA8 B 1 V74 H233 E236 S272 E273 Y308 D335 E377 L411 R412 V73 H218 E221 S257 E258 Y293 D320 E362 L396 R397 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPERWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKARE 6wtf B 2.19 BS04 TRP B 1 V74 Y308 N331 M375 E377 N527 Y529 V73 Y293 N316 M360 E362 N503 Y505 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPERWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKARE 6x5g A 1.85 BS01 III B 1 E96 F98 I101 K137 E139 F173 A174 G175 T176 P177 G178 Y179 G209 Y210 P211 W214 Y222 Q224 P233 E90 F92 I95 K131 E133 F167 A168 G169 T170 P171 G172 Y173 G203 Y204 P205 W208 Y216 Q218 P227 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6x5q A 2.14 BS01 III B 1 F98 I101 V102 E105 K137 E139 F173 A174 G175 T176 P177 G178 Y179 I205 V208 G209 Y210 W214 Y222 P233 S234 E236 F91 I94 V95 E98 K130 E132 F166 A167 G168 T169 P170 G171 Y172 I198 V201 G202 Y203 W207 Y215 P226 S227 E229 2.7.11.17 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6x8v A 2.56 BS01 III C 1 E96 F98 E99 I101 V102 E105 Y106 K137 E139 F173 G175 T176 G178 V208 G209 Y210 P211 W214 P233 E236 E90 F92 E93 I95 V96 E99 Y100 K131 E133 F167 G169 T170 G172 V202 G203 Y204 P205 W208 P227 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6x8v B 2.56 BS01 III D 1 E96 F98 E105 K137 E139 F173 G175 T176 P177 G178 Y179 I205 V208 G209 Y210 W214 Y222 P233 S234 E236 E86 F88 E95 K127 E129 F163 G165 T166 P167 G168 Y169 I195 V198 G199 Y200 W204 Y212 P223 S224 E226 2.7.11.17 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 6xbp A 2.25 BS01 III C 1 K56 E96 F98 E99 I101 N135 K137 E139 L159 F173 A174 G175 T176 P177 G178 Y179 I205 G209 Y210 P211 P212 W214 Q218 E236 K50 E90 F92 E93 I95 N129 K131 E133 L153 F167 A168 G169 T170 P171 G172 Y173 I199 G203 Y204 P205 P206 W208 Q212 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xbp A 2.25 BS02 UZD A 1 L19 A40 V73 F89 D90 L91 V92 D156 L13 A34 V67 F83 D84 L85 V86 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xbp B 2.25 BS01 III D 1 R52 K56 E96 F98 E99 N135 K137 E139 L159 F173 A174 G175 T176 P177 G178 Y179 I205 G209 Y210 P211 W214 Q218 P233 S234 E236 R46 K50 E90 F92 E93 N129 K131 E133 L153 F167 A168 G169 T170 P171 G172 Y173 I199 G203 Y204 P205 W208 Q212 P227 S228 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xbp B 2.25 BS02 UZD B 1 L19 A40 V73 F89 D90 L91 V92 D156 L13 A34 V67 F83 D84 L85 V86 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xbx A 2.56 BS01 III C 1 E96 F98 E99 I101 N135 K137 E139 L159 F173 A174 G175 T176 P177 G178 Y179 I205 G209 Y210 P211 W214 Q218 Y222 E90 F92 E93 I95 N129 K131 E133 L153 F167 A168 G169 T170 P171 G172 Y173 I199 G203 Y204 P205 W208 Q212 Y216 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xbx A 2.56 BS02 ATP A 1 L19 A40 V73 F89 D90 L91 V92 E96 N135 K137 N140 L142 D156 L13 A34 V67 F83 D84 L85 V86 E90 N129 K131 N134 L136 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xbx A 2.56 BS03 MG A 1 E139 N140 D156 E133 N134 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xbx B 2.56 BS01 III D 1 R52 E96 F98 E99 I101 N135 K137 E139 L159 F173 A174 G175 T176 P177 G178 Y179 I205 G209 Y210 P211 W214 Q218 S234 E236 R46 E90 F92 E93 I95 N129 K131 E133 L153 F167 A168 G169 T170 P171 G172 Y173 I199 G203 Y204 P205 W208 Q212 S228 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 6xbx B 2.56 BS02 ATP B 1 L19 K21 V27 A40 V73 D90 L91 V92 N135 K137 N140 L142 D156 L13 K15 V21 A34 V67 D84 L85 V86 N129 K131 N134 L136 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 6xbx B 2.56 BS03 MG B 1 E139 N140 D156 E133 N134 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 6xd9 A 2.10 BS01 HEM A 1 Y42 F43 H45 F46 H58 K61 V62 A65 L66 L83 L86 H87 L91 V93 N97 F98 L101 Y42 F43 H45 F46 H58 K61 V62 A65 L66 L83 L86 H87 L91 V93 N97 F98 L101 33219275 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 6xd9 A 2.10 BS02 V39 A 1 V1 M76 P77 K127 S131 T134 V1 M76 P77 K127 S131 T134 33219275 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 6xd9 A 2.10 BS03 V39 C 1 V1 T134 V1 T134 33219275 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 6xd9 B 2.10 BS01 HEM B 1 T38 F41 F42 F45 H63 K66 A70 F71 L88 L91 H92 L96 V98 N102 F103 L106 L141 T38 F41 F42 F45 H63 K66 A70 F71 L88 L91 H92 L96 V98 N102 F103 L106 L141 33219275 VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH 6xd9 C 2.10 BS01 V39 A 1 V1 T134 V1 T134 33219275 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 6xd9 C 2.10 BS02 HEM C 1 Y42 F43 F46 H58 K61 A65 L66 L83 H87 L91 N97 F98 L101 Y42 F43 F46 H58 K61 A65 L66 L83 H87 L91 N97 F98 L101 33219275 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 6xd9 C 2.10 BS03 V39 C 1 V1 M76 P77 S131 T134 V1 M76 P77 S131 T134 33219275 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 6xd9 D 2.10 BS01 HEM D 1 T38 F41 F42 F45 H63 K66 V67 A70 F71 L88 L91 H92 L96 V98 N102 F103 L106 L141 T38 F41 F42 F45 H63 K66 V67 A70 F71 L88 L91 H92 L96 V98 N102 F103 L106 L141 33219275 VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH 6xdl A 1.96 BS01 III B 1 R52 K56 E96 F98 V102 D135 K137 E139 L159 F173 A174 G175 T176 P177 G178 Y179 G209 W214 Q218 H219 R46 K50 E90 F92 V96 D129 K131 E133 L153 F167 A168 G169 T170 P171 G172 Y173 G203 W208 Q212 H213 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xdu A 2.80 BS01 III B 1 R52 K56 E96 F98 I101 D135 K137 E139 L159 F173 A174 G175 T176 G178 Y179 I205 G209 W214 Q218 H219 R46 K50 E90 F92 I95 D129 K131 E133 L153 F167 A168 G169 T170 G172 Y173 I199 G203 W208 Q212 H213 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xdu A 2.80 BS02 ADP A 1 L19 G20 K21 S25 V27 A40 K42 D90 V92 D156 L13 G14 K15 S19 V21 A34 K36 D84 V86 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xew A 2.00 BS01 NAD A 1 G12 N15 G16 M17 D36 W37 I59 D60 V61 N87 A88 G89 V90 V110 T136 A137 S138 Y151 K155 P181 S182 L183 V184 T186 N187 M188 T189 G12 N15 G16 M17 D36 W37 I59 D60 V61 N87 A88 G89 V90 V110 T136 A137 S138 Y151 K155 P181 S182 L183 V184 T186 N187 M188 T189 1.-.-.- 33292448 GRFDNKVVVITGAGNGMGEAAARRFSAEGAIVVLADWAKEAVDKVAASLPKGRAMAVHIDVSDHVAVEKMMNEVAEKLGRIDVLLNNAGVHVAGSVLETSIDDWRRIAGVDIDGVVFCSKFALPHLLKTKGCIVNTASVSGLGGDWGAAYYCAAKGAVVNLTRAMALDHGGDGVRINSVCPSLVKTNMTNGWPQEIRDKFNERIALGRAAEPEEVAAVMAFLASDDASFINGANIPVDGGATASDGQPKIV 6xew A 2.00 BS02 NAD A 2 W37 A38 N187 W37 A38 N187 1.-.-.- 33292448 GRFDNKVVVITGAGNGMGEAAARRFSAEGAIVVLADWAKEAVDKVAASLPKGRAMAVHIDVSDHVAVEKMMNEVAEKLGRIDVLLNNAGVHVAGSVLETSIDDWRRIAGVDIDGVVFCSKFALPHLLKTKGCIVNTASVSGLGGDWGAAYYCAAKGAVVNLTRAMALDHGGDGVRINSVCPSLVKTNMTNGWPQEIRDKFNERIALGRAAEPEEVAAVMAFLASDDASFINGANIPVDGGATASDGQPKIV 6xew A 2.00 BS03 HBR A 1 S138 S140 Y151 M188 W192 S138 S140 Y151 M188 W192 1.-.-.- 33292448 GRFDNKVVVITGAGNGMGEAAARRFSAEGAIVVLADWAKEAVDKVAASLPKGRAMAVHIDVSDHVAVEKMMNEVAEKLGRIDVLLNNAGVHVAGSVLETSIDDWRRIAGVDIDGVVFCSKFALPHLLKTKGCIVNTASVSGLGGDWGAAYYCAAKGAVVNLTRAMALDHGGDGVRINSVCPSLVKTNMTNGWPQEIRDKFNERIALGRAAEPEEVAAVMAFLASDDASFINGANIPVDGGATASDGQPKIV 6xew A 2.00 BS04 HBS A 1 S138 Y151 P181 S182 M188 W192 S138 Y151 P181 S182 M188 W192 1.-.-.- 33292448 GRFDNKVVVITGAGNGMGEAAARRFSAEGAIVVLADWAKEAVDKVAASLPKGRAMAVHIDVSDHVAVEKMMNEVAEKLGRIDVLLNNAGVHVAGSVLETSIDDWRRIAGVDIDGVVFCSKFALPHLLKTKGCIVNTASVSGLGGDWGAAYYCAAKGAVVNLTRAMALDHGGDGVRINSVCPSLVKTNMTNGWPQEIRDKFNERIALGRAAEPEEVAAVMAFLASDDASFINGANIPVDGGATASDGQPKIV 6xew B 2.00 BS01 ADP B 1 G12 G14 N15 D36 W37 I59 D60 V61 A88 G89 V110 G12 G14 N15 D36 W37 I59 D60 V61 A88 G89 V110 1.-.-.- 33292448 GRFDNKVVVITGAGNGMGEAAARRFSAEGAIVVLADWAKEAVDKVAASLPKGRAMAVHIDVSDHVAVEKMMNEVAEKLGRIDVLLNNAGVHVAGSVLETSIDDWRRIAGVDIDGVVFCSKFALPHLLKTKGCIVNTASVSGLGGDWGAAYYCAAKGAVVNLTRAMALDHGGDGVRINSVCPSLVKTNMTNGWPQEIRDKFNERIALGRAAEPEEVAAVMAFLASDDASFINGANIPVDGGATASDGQPKIV 6xex A 1.80 BS01 NAD A 1 G12 N15 G16 M17 D36 W37 I59 D60 V61 N87 A88 G89 V90 V110 T136 A137 S138 Y151 K155 P181 S182 L183 V184 T186 N187 M188 T189 G12 N15 G16 M17 D36 W37 I59 D60 V61 N87 A88 G89 V90 V110 T136 A137 S138 Y151 K155 P181 S182 L183 V184 T186 N187 M188 T189 1.-.-.- 33292448 GRFDNKVVVITGAGNGMGEAAARRFSAEGAIVVLADWAKEAVDKVAASLPKGRAMAVHIDVSDHVAVEKMMNEVAEKLGRIDVLLNNAGVHVAGSVLETSIDDWRRIAGVDIDGVVFCSKFALPHLLKTKGCIVNTASQSGLGGDWGAAYYCAAKGAVVNLTRAMALDHGGDGVRINSVCPSLVKTNMTNGWPQEIRDKFNERIALGRAAEPEEVAAVMAFLASDDASFINGANIPVDGGATASDGAPKIV 6xf0 A 2.71 BS01 III C 1 E96 F98 E99 E105 K137 E139 G175 T176 P177 G178 Y179 I205 V208 G209 Y210 P211 W214 P233 S234 E236 E90 F92 E93 E99 K131 E133 G169 T170 P171 G172 Y173 I199 V202 G203 Y204 P205 W208 P227 S228 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xf0 A 2.71 BS02 MG A 1 N140 D156 N134 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xf0 A 2.71 BS03 ATP A 1 G22 A23 V27 A40 K42 V73 F89 D90 V92 E96 L142 D156 G16 A17 V21 A34 K36 V67 F83 D84 V86 E90 L136 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xf0 B 2.71 BS01 III D 1 E96 F98 E99 V102 E105 Y106 K137 E139 F173 G175 T176 P177 G178 Y179 I205 V208 G209 Y210 P211 W214 P233 S234 E236 E86 F88 E89 V92 E95 Y96 K127 E129 F163 G165 T166 P167 G168 Y169 I195 V198 G199 Y200 P201 W204 P223 S224 E226 2.7.11.17 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 6xf0 B 2.71 BS02 ATP B 1 L19 G20 G22 A23 S25 V27 A40 K42 D90 V92 E96 L142 D156 L159 L12 G13 G15 A16 S18 V20 A33 K35 D80 V82 E86 L132 D146 L149 2.7.11.17 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 6xly A 3.10 BS01 ZN A 1 H493 R628 H476 R611 ARPQDDLFGHVNGRWLAEHEIPADRATDGAFRSLFDRAETQVRDLIIQASQAGAAVGTDAQRIGDLYASFLDEEAVERAGVQPLHDELATIDSAADATELAAALGTLQRAGVGGGIGVYVDTDSKDSTRYLVHFTQSGIGLPDESYYRDEQHAAVLAAYPGHIARMFGLVYGGESRDHAKTADRIVALETKLADAHWDVVKRRDADLGYNLRTFAQLQTEGAGFDWVSWVTALGSAPDAMTELVVRQPDYLVTFASLWASVNVEDWKCWARWRLIRARAPWLTRALVAEDFEFYGRTLTGAQQLRDRWKRGVSLVENLMGDAVGKLYVQRHFPPDAKSRIDTLVDNLQEAYRISISELDWMTPQTRQRALAKLNKFTAKVGYPIKWRDYSKLAIDRDDLYGNVQRGYAVNHDRELAKLFGPVDRDEWFMTPQTVNAYYNPGMNEIVFPAAILQPPFFDPQADEAANYGGIGAVIGHEIGHGFDDQGAKYDGDGNLVDWWTDDDRTEFAARTKALIEQYHAYTPRDLVDHPGPPHVQGAFTIGENIGDLGGLSIALLAYQLSLNGNPAPVIDGLTGMQRVFFGWAQIWRTKSRAAEAIRRLAVDPHSPPEFRCNGVVRNVDAFYQAFDVTEDDALFLDPQRRVRIWN 6xoe A 2.10 BS01 III B 1 R52 E96 F98 I101 N135 K137 E139 L159 F173 A174 G175 T176 P177 G178 G209 Y210 P211 P212 W214 Q218 H219 P233 S234 E236 R46 E90 F92 I95 N129 K131 E133 L153 F167 A168 G169 T170 P171 G172 G203 Y204 P205 P206 W208 Q212 H213 P227 S228 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6xoe A 2.10 BS02 ATP A 1 L19 G20 G22 S25 V27 A40 K42 D90 V92 L13 G14 G16 S19 V21 A34 K36 D84 V86 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 6y26 A 1.20 BS01 III C 1 Y7 H9 T24 V25 V34 E45 E63 I66 C67 T73 E76 D77 T80 L81 Y84 Y99 H114 T143 K146 W147 V152 Q155 L156 Y159 W167 Y171 Y7 H9 T24 V25 V34 E45 E63 I66 C67 T73 E76 D77 T80 L81 Y84 Y99 H114 T143 K146 W147 V152 Q155 L156 Y159 W167 Y171 GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP 6y27 A 1.38 BS01 III C 1 Y7 H9 T24 E45 E63 I66 C67 E76 D77 Y84 Y99 T143 K146 W147 V152 L156 Y159 W167 Y171 Y7 H9 T24 E45 E63 I66 C67 E76 D77 Y84 Y99 T143 K146 W147 V152 L156 Y159 W167 Y171 GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQHAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP 6y28 A 1.69 BS01 III C 1 Y7 H9 T24 E45 E63 I66 C67 E76 D77 Y84 Y99 T143 K146 W147 L156 Y159 W167 Y171 Y7 H9 T24 E45 E63 I66 C67 E76 D77 Y84 Y99 T143 K146 W147 L156 Y159 W167 Y171 GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP 6y29 A 1.28 BS01 III C 1 Y7 H9 T24 V25 V34 E45 E63 I66 C67 T73 E76 D77 T80 L81 Y84 Y99 H114 T143 K146 W147 V152 L156 Y159 W167 Y171 Y7 H9 T24 V25 V34 E45 E63 I66 C67 T73 E76 D77 T80 L81 Y84 Y99 H114 T143 K146 W147 V152 L156 Y159 W167 Y171 GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQHAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP 6y2a A 1.25 BS01 III C 1 Y7 H9 T24 V25 V34 E45 E63 I66 C67 T73 E76 D77 T80 L81 Y84 Y99 H114 Y123 T143 K146 W147 V152 Q155 L156 Y159 W167 Y171 Y7 H9 T24 V25 V34 E45 E63 I66 C67 T73 E76 D77 T80 L81 Y84 Y99 H114 Y123 T143 K146 W147 V152 Q155 L156 Y159 W167 Y171 GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP 6y2b A 1.37 BS01 III C 1 Y7 H9 T24 E45 E63 I66 C67 E76 D77 Y84 Y99 T143 K146 W147 V152 Q155 L156 Y159 W167 Y171 Y7 H9 T24 E45 E63 I66 C67 E76 D77 Y84 Y99 T143 K146 W147 V152 Q155 L156 Y159 W167 Y171 GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQHAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP 6y5a A 2.80 BS01 SRO A 1 W63 Y64 R65 Y126 K127 W56 Y57 R58 Y119 K120 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a A 2.80 BS02 SRO B 1 T154 S155 W156 I201 Y207 T147 S148 W149 I194 Y200 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a C 2.80 BS01 SRO C 1 W63 Y64 R65 Y126 K127 W56 Y57 R58 Y119 K120 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a C 2.80 BS02 SRO D 1 S155 W156 F199 I201 Y207 S148 W149 F192 I194 Y200 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a D 2.80 BS01 SRO D 1 W63 Y64 R65 Y126 K127 W56 Y57 R58 Y119 K120 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a D 2.80 BS02 SRO E 1 T154 S155 W156 Y207 T147 S148 W149 Y200 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a B 2.80 BS01 SRO C 1 T154 S155 W156 I201 Y207 T147 S148 W149 I194 Y200 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a B 2.80 BS02 SRO B 1 W63 Y64 R65 Y126 K127 W56 Y57 R58 Y119 K120 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a E 2.80 BS01 SRO A 1 T154 S155 W156 F199 I201 Y207 T147 S148 W149 F192 I194 Y200 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6y5a E 2.80 BS02 SRO E 1 W63 Y64 R65 Y126 K127 W56 Y57 R58 Y119 K120 TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS 6yge B 1.60 BS01 CA B 1 S216 D219 E220 E223 S190 D193 E194 E197 SLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPNQ 6yge A 1.60 BS01 CA A 1 S216 D219 E220 E223 S191 D194 E195 E198 DSLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPN 6ygf B 1.70 BS01 FUC C 1 T42 P94 T17 P69 DSLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPNQ 6ygf A 1.70 BS01 FUC E 1 T42 A93 P94 T18 A69 P70 EDSLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPN 6ygf A 1.70 BS02 NCA A 1 R129 F130 F137 L138 A139 R148 L150 I182 Q194 R105 F106 F113 L114 A115 R124 L126 I158 Q170 EDSLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPN 6ygf A 1.70 BS03 AR6 A 1 Y100 R129 G131 S132 N154 F158 Y76 R105 G107 S108 N130 F134 EDSLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPN 6ygg A 1.85 BS01 FUC D 1 T42 P94 T17 P69 DSLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPNQ 6ygg A 1.85 BS02 CA A 1 S216 D219 E220 E223 S191 D194 E195 E198 DSLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPNQ 6ygg B 1.85 BS01 DQV B 1 Y100 P101 R129 F130 Y134 G135 T136 F137 L138 R148 L150 I182 Q194 Y74 P75 R103 F104 Y108 G109 T110 F111 L112 R122 L124 I156 Q168 SLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPNQD 6ygg B 1.85 BS02 CA B 1 S216 D219 E220 E223 S190 D193 E194 E197 SLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPNQD 6yjb A 1.55 BS01 NUC B 1 S7 Q8 K9 Q10 T11 E15 W22 S23 P24 N27 K28 Y36 W82 N125 G126 N127 Q128 A129 Y130 S7 Q8 K9 Q10 T11 E15 W22 S23 P24 N27 K28 Y36 W82 N125 G126 N127 Q128 A129 Y130 MNYWWVSQKQTFKQEFEGGYMWSPKENKNGTQSHYYNNMTLVQPGDVVFSFANGLILSVGIARSHAYSYNKPTEFGVAGADWANDGWKIDLEYHLVENKIRPKAHIDFIRPYLPQKYSPLQDNGNGNQAYLFSVPHELASKVVELIGSEAEEVIFGFADTTEITTTADAIECQISNDASIDETEKHQLVKSRRGQGIFRSRLEQVESRCRVTGVQLKNHLIASHIKPWAVSNNQERLDGHNGLLLAPHVDHLFDKGFISFEDNGEMIVSEKLNLDVLKAWSISQGNYGYFSKQQQEYMCYHRENVFKKL 6ykf A 1.48 BS01 NUC B 1 S7 Q8 K9 Q10 T11 E15 W22 N27 K28 Y36 W82 N125 G126 N127 Q128 A129 Y130 S7 Q8 K9 Q10 T11 E15 W22 N27 K28 Y36 W82 N125 G126 N127 Q128 A129 Y130 MNYWWVSQKQTFKQEFEGGYMWSPKENKNGTQSHYYNNMTLVQPGDVVFSFANGLILSVGIARSHAYSYNKPTEFGVAGADWANDGWKIDLEYHLVENKIRPKAHIDFIRPYLPQKYSPLQDNGNGNQAYLFSVPHELASKVVELIGSEAEEVIFGFADTTEITTTADAIECQISNDASIDETEKHQLVKSRRGQGIFRSRLEQVESRCRVTGVQLKNHLIASHIKPWAVSNNQERLDGHNGLLLAPHVDHLFDKGFISFEDNGEMIVSEKLNLDVLKAWSISQGNYGYFSKQQQEYMCYHRENVFKKL 6ymg A 3.14 BS01 NUC C 1 S7 Q8 K9 Q10 T11 E15 W22 N27 K28 N29 Y36 F51 W82 K103 N125 G126 N127 Q128 Y130 S7 Q8 K9 Q10 T11 E15 W22 N27 K28 N29 Y36 F51 W82 K103 N125 G126 N127 Q128 Y130 MNYWWVSQKQTFKQEFEGGYMWSPKENKNGTQSHYYNNMTLVQPGDVVFSFANGLILSVGIARSHAYSYNKPTEFGVAGADWANDGWKIDLEYHLVENKIRPKAHIDFIRPYLPQKYSPLQDNGNGNQAYLFSVPHELASKVVELIGSEAEEVIFGFADTTEITTTADAIECQISNDASIDETEKHQLVKSRRGQGIFRSRLEQVESRCRVTGVQLKNHLIASHIKPWAVSNNQERLDGHNGLLLAPHVDHLFDKGFISFEDNGEMIVSEKLNLDVLKAWSISQGNYGYFSKQQQEYMCYHRENVFKKL 6ymg A 3.14 BS02 NUC D 1 Y35 K116 Y117 Q121 N127 Q128 Y35 K116 Y117 Q121 N127 Q128 MNYWWVSQKQTFKQEFEGGYMWSPKENKNGTQSHYYNNMTLVQPGDVVFSFANGLILSVGIARSHAYSYNKPTEFGVAGADWANDGWKIDLEYHLVENKIRPKAHIDFIRPYLPQKYSPLQDNGNGNQAYLFSVPHELASKVVELIGSEAEEVIFGFADTTEITTTADAIECQISNDASIDETEKHQLVKSRRGQGIFRSRLEQVESRCRVTGVQLKNHLIASHIKPWAVSNNQERLDGHNGLLLAPHVDHLFDKGFISFEDNGEMIVSEKLNLDVLKAWSISQGNYGYFSKQQQEYMCYHRENVFKKL 6ymg B 3.14 BS01 NUC E 1 S7 Q8 K9 Q10 T11 E15 W22 N27 K28 N29 Y36 W82 G126 N127 Q128 A129 Y130 S7 Q8 K9 Q10 T11 E15 W22 N27 K28 N29 Y36 W82 G126 N127 Q128 A129 Y130 MNYWWVSQKQTFKQEFEGGYMWSPKENKNGTQSHYYNNMTLVQPGDVVFSFANGLILSVGIARSHAYSYNKPTEFGVAGADWANDGWKIDLEYHLVENKIRPKAHIDFIRPYLPQKYSPLQDNGNGNQAYLFSVPHELASKVVELIGSEAEEVIFGFADTTEITTTADAIECQISNDASIDETEKHQLVKSRRGQGIFRSRLEQVESRCRVTGVQLKNHLIASHIKPWAVSNNQERLDGHNGLLLAPHVDHLFDKGFISFEDNGEMIVSEKLNLDVLKAWSISQGNYGYFSKQQQEYMCYHRENVFKKL 6ymg B 3.14 BS02 NUC F 1 Y35 K116 Y117 Q121 N127 Q128 Y35 K116 Y117 Q121 N127 Q128 MNYWWVSQKQTFKQEFEGGYMWSPKENKNGTQSHYYNNMTLVQPGDVVFSFANGLILSVGIARSHAYSYNKPTEFGVAGADWANDGWKIDLEYHLVENKIRPKAHIDFIRPYLPQKYSPLQDNGNGNQAYLFSVPHELASKVVELIGSEAEEVIFGFADTTEITTTADAIECQISNDASIDETEKHQLVKSRRGQGIFRSRLEQVESRCRVTGVQLKNHLIASHIKPWAVSNNQERLDGHNGLLLAPHVDHLFDKGFISFEDNGEMIVSEKLNLDVLKAWSISQGNYGYFSKQQQEYMCYHRENVFKKL 6yx5 A 2.14 BS01 MG A 1 T22 T40 T20 T38 SHMDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDK 6yx5 A 2.14 BS02 GNP A 1 S17 G18 V19 G20 K21 T22 C23 F33 N34 S35 T36 F37 S39 T40 G66 N121 K122 D124 V125 S151 A152 K153 S15 G16 V17 G18 K19 T20 C21 F31 N32 S33 T34 F35 S37 T38 G64 N119 K120 D122 V123 S149 A150 K151 SHMDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDK 6yx5 A 2.14 BS03 GLC A 1 C123 N126 R129 E149 I156 N157 C121 N124 R127 E147 I154 N155 SHMDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDK 6yx5 B 2.14 BS01 LJN A 1 K90 D91 E93 K118 P193 R194 C197 K77 D78 E80 K105 P180 R181 C184 HMFGSLYSDERDKPLLSPTAQKKFEEYQNKLANLSKIIRENEGNEVSPWQEWENGLRQIYKEMIYDAFDALGVEMPKDMEVHFAGSLAKAQATEYSDLDAFVIVKNDEDIKKVKPVFDALNNLCQRIFTASNQIYPDPIGINPSRLIGTPDDLFGMLKDGMVADVEATAMSILTSKPVLPRYECGEELRDKIKQEPSFSNMVSAKKFYNKAIKDFTAPKEGAEVVSVKTHIMRPIDFMLMGLREEFNLYSEDGAHLSAPGTIRLLREKNLLPEEQIARIESVYNQAMSKRFELHAEHKKEHDEMPYSDAKAMLDEVAKIRELGVQRVTRIENLENAKKL 6yx5 B 2.14 BS02 GLC B 1 G98 S99 K102 R246 D249 F250 M253 G85 S86 K89 R233 D236 F237 M240 HMFGSLYSDERDKPLLSPTAQKKFEEYQNKLANLSKIIRENEGNEVSPWQEWENGLRQIYKEMIYDAFDALGVEMPKDMEVHFAGSLAKAQATEYSDLDAFVIVKNDEDIKKVKPVFDALNNLCQRIFTASNQIYPDPIGINPSRLIGTPDDLFGMLKDGMVADVEATAMSILTSKPVLPRYECGEELRDKIKQEPSFSNMVSAKKFYNKAIKDFTAPKEGAEVVSVKTHIMRPIDFMLMGLREEFNLYSEDGAHLSAPGTIRLLREKNLLPEEQIARIESVYNQAMSKRFELHAEHKKEHDEMPYSDAKAMLDEVAKIRELGVQRVTRIENLENAKKL 6yx5 B 2.14 BS03 GLC B 2 L186 R202 K206 R256 E257 N260 L261 H268 L269 L173 R189 K193 R243 E244 N247 L248 H255 L256 HMFGSLYSDERDKPLLSPTAQKKFEEYQNKLANLSKIIRENEGNEVSPWQEWENGLRQIYKEMIYDAFDALGVEMPKDMEVHFAGSLAKAQATEYSDLDAFVIVKNDEDIKKVKPVFDALNNLCQRIFTASNQIYPDPIGINPSRLIGTPDDLFGMLKDGMVADVEATAMSILTSKPVLPRYECGEELRDKIKQEPSFSNMVSAKKFYNKAIKDFTAPKEGAEVVSVKTHIMRPIDFMLMGLREEFNLYSEDGAHLSAPGTIRLLREKNLLPEEQIARIESVYNQAMSKRFELHAEHKKEHDEMPYSDAKAMLDEVAKIRELGVQRVTRIENLENAKKL 6yym A 2.63 BS01 NUC B 1 N582 M600 K602 N603 N606 K607 Y629 R631 I632 D633 F634 V635 N636 C638 V640 G641 Y642 F644 V667 F668 H669 S670 E671 K672 S677 Y678 A679 N680 I681 K690 F691 C695 V696 N3 M21 K23 N24 N27 K28 Y50 R52 I53 D54 F55 V56 N57 C59 V61 G62 Y63 F65 V88 F89 H90 S91 E92 K93 S98 Y99 A100 N101 I102 K111 F112 C116 V117 DRNSVDYAQIASGIDTRTTVMIKNIPNKFTQQMLRDYIDVTNKGTYDFLYLRIDFVNKCNVGYAFINFIEPQSIITFGKARVGTQWNVFHSEKICDISYANIQGKDRLIEKFRNSCVMDENPAYRPKIFVSHGPNRGMEEPFPAPNNA 6z23 A 1.31 BS01 CEF A 1 C69 S70 W105 S130 N132 L167 N170 T235 T237 C238 G239 C44 S45 W80 S105 N107 L142 N145 T210 T212 C213 G214 3.5.2.6 33257320 LTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWQLELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNG 6z24 A 1.25 BS01 CAZ A 1 C69 S70 W105 S130 N132 K234 T235 G236 T237 C238 G239 V240 C46 S47 W82 S107 N109 K204 T205 G206 T207 C208 G209 V210 3.5.2.6 33257320 HMLTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNSEAVIAAAARLALEGLGVNG 6z25 A 1.24 BS01 CAZ A 1 C69 S70 R104 W105 S130 N132 N170 S171 R220 K234 T235 G236 T237 C238 G239 C46 S47 R81 W82 S107 N109 N147 S148 R197 K211 T212 G213 T214 C215 G216 3.5.2.6 33257320 HMLTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVRWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWQLELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGGYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNG 6z45 A 3.37 BS01 Q6E A 1 I25 V33 A46 V79 F103 D104 F105 C106 E107 H108 D109 N154 L156 I21 V29 A42 V75 F93 D94 F95 C96 E97 H98 D99 N144 L146 2.7.11.22,2.7.11.23 33306391 YDDNECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQRVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLFYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLNPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLAAYVRDPYALDLIDKLLVLDPAQRIDSEDALEHDFFWSDPMPSDLKGML 6zci A 1.98 BS01 QFN A 1 W81 P82 F83 Q85 V87 L92 Y139 N140 D145 I146 M149 W40 P41 F42 Q44 V46 L51 Y98 N99 D104 I105 M108 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE 6zhx A 2.50 BS01 NUC I 1 R40 Y41 R42 P43 T45 R63 R72 R83 F84 Q85 S86 R116 V117 T118 M120 R3 Y4 R5 P6 T8 R26 R35 R46 F47 Q48 S49 R79 V80 T81 M83 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGER 6zhx A 2.50 BS02 NUC J 1 H39 R40 Y41 R42 P43 G44 T45 V46 A47 R49 R63 K64 L65 P66 R69 R83 H2 R3 Y4 R5 P6 G7 T8 V9 A10 R12 R26 K27 L28 P29 R32 R46 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGER 6zhx B 2.50 BS01 NUC I 1 T30 P32 R36 R45 T80 T11 P13 R17 R26 T61 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6zhx B 2.50 BS02 NUC J 1 R35 R45 I46 S47 G48 R78 K79 T80 R16 R26 I27 S28 G29 R59 K60 T61 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6zhx C 2.50 BS01 NUC I 1 R17 G28 R32 R42 R77 R2 G13 R17 R27 R62 TRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPK 6zhx C 2.50 BS02 NUC J 1 T16 R29 R35 R42 V43 G44 A45 K75 T76 R77 T1 R14 R20 R27 V28 G29 A30 K60 T61 R62 TRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPK 6zhx C 2.50 BS03 III L 1 Y57 E61 E64 L65 D90 E92 L93 Y42 E46 E49 L50 D75 E77 L78 TRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPK 6zhx D 2.50 BS01 NUC I 1 T29 R30 E32 Y39 G50 I51 S52 S53 R83 S84 T85 T2 R3 E5 Y12 G23 I24 S25 S26 R56 S57 T58 KTRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK 6zhx D 2.50 BS02 NUC J 1 R30 K31 E32 I36 Y37 K40 R3 K4 E5 I9 Y10 K13 KTRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK 6zhx D 2.50 BS03 III L 1 E102 L103 H106 E110 K113 E75 L76 H79 E83 K86 KTRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK 6zhx E 2.50 BS01 NUC I 1 R40 Y41 R42 P43 G44 T45 V46 A47 R49 R63 K64 L65 P66 R69 R83 R2 Y3 R4 P5 G6 T7 V8 A9 R11 R25 K26 L27 P28 R31 R45 HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGERA 6zhx E 2.50 BS02 NUC J 1 R40 Y41 R42 P43 T45 R63 R72 R83 F84 Q85 R116 V117 T118 M120 R2 Y3 R4 P5 T7 R25 R34 R45 F46 Q47 R78 V79 T80 M82 HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGERA 6zhx F 2.50 BS01 NUC I 1 R45 I46 S47 G48 R78 K79 T80 R21 I22 S23 G24 R54 K55 T56 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6zhx F 2.50 BS02 NUC J 1 T30 P32 R36 R45 T80 T6 P8 R12 R21 T56 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6zhx G 2.50 BS01 NUC I 1 T16 R29 R42 V43 G44 A45 K75 T76 R77 T3 R16 R29 V30 G31 A32 K62 T63 R64 AKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPK 6zhx G 2.50 BS02 NUC J 1 K15 T16 R17 R20 G28 R32 R42 R77 K2 T3 R4 R7 G15 R19 R29 R64 AKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPK 6zhx G 2.50 BS03 III K 1 Y57 E61 E64 L65 D90 E92 L93 Y44 E48 E51 L52 D77 E79 L80 AKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPK 6zhx H 2.50 BS01 NUC I 1 R30 K31 E32 S33 I36 Y37 R2 K3 E4 S5 I8 Y9 TRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 6zhx H 2.50 BS02 NUC J 1 T29 R30 Y39 G50 I51 S52 S53 R83 S84 T85 T1 R2 Y11 G22 I23 S24 S25 R55 S56 T57 TRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 6zhx H 2.50 BS03 III K 1 E102 L103 H106 E110 E74 L75 H78 E82 TRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 6zhy A 3.00 BS01 NUC I 1 R42 P43 R63 R72 R83 F84 Q85 S86 R116 V117 T118 M120 R5 P6 R26 R35 R46 F47 Q48 S49 R79 V80 T81 M83 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGER 6zhy A 3.00 BS02 NUC J 1 R40 Y41 R42 P43 G44 T45 V46 A47 R63 K64 L65 P66 R69 R83 R3 Y4 R5 P6 G7 T8 V9 A10 R26 K27 L28 P29 R32 R46 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGER 6zhy B 3.00 BS01 NUC I 1 T30 P32 R36 R45 T11 P13 R17 R26 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6zhy B 3.00 BS02 NUC J 1 R35 R39 R45 I46 S47 G48 R78 K79 T80 R16 R20 R26 I27 S28 G29 R59 K60 T61 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6zhy C 3.00 BS01 NUC I 1 T16 R17 G28 R32 E41 R42 R77 T1 R2 G13 R17 E26 R27 R62 TRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPK 6zhy C 3.00 BS02 NUC J 1 R29 R35 R42 V43 G44 A45 K75 T76 R77 R14 R20 R27 V28 G29 A30 K60 T61 R62 TRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPK 6zhy C 3.00 BS03 III K 1 E56 Y57 A60 E61 L65 D90 E92 L93 E41 Y42 A45 E46 L50 D75 E77 L78 TRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPK 6zhy D 3.00 BS01 NUC I 1 T29 R30 Y39 G50 I51 S52 S53 R83 S84 T85 T2 R3 Y12 G23 I24 S25 S26 R56 S57 T58 KTRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK 6zhy D 3.00 BS02 NUC J 1 R30 K31 E32 S33 I36 Y37 R3 K4 E5 S6 I9 Y10 KTRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK 6zhy D 3.00 BS03 III K 1 V45 H106 E110 V18 H79 E83 KTRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK 6zhy E 3.00 BS01 NUC I 1 R40 Y41 R42 P43 G44 T45 V46 A47 R49 R63 K64 L65 P66 R69 R83 R2 Y3 R4 P5 G6 T7 V8 A9 R11 R25 K26 L27 P28 R31 R45 HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGERA 6zhy E 3.00 BS02 NUC J 1 R40 Y41 R42 P43 T45 R63 R72 R83 F84 Q85 R116 V117 T118 M120 R2 Y3 R4 P5 T7 R25 R34 R45 F46 Q47 R78 V79 T80 M82 HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGERA 6zhy F 3.00 BS01 NUC I 1 R45 I46 S47 G48 R78 K79 T80 R21 I22 S23 G24 R54 K55 T56 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6zhy F 3.00 BS02 NUC J 1 T30 P32 R36 R45 T80 T6 P8 R12 R21 T56 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6zja B 2.00 BS01 DJM B 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja J 2.00 BS01 DJM J 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja D 2.00 BS01 DJM D 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja F 2.00 BS01 DJM F 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja H 2.00 BS01 DJM H 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja L 2.00 BS01 DJM L 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja N 2.00 BS01 DJM N 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja P 2.00 BS01 DJM P 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja R 2.00 BS01 DJM R 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja T 2.00 BS01 DJM T 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja V 2.00 BS01 DJM V 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zja X 2.00 BS01 DJM X 1 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 A169 K219 H221 H248 A278 G279 M317 C321 H322 M366 3.5.1.5 MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF 6zmp A 1.57 BS01 III C 1 F23 T24 E25 T26 Y27 E28 H80 T82 A83 V84 F118 Y144 Y145 G146 F22 T23 E24 T25 Y26 E27 H79 T81 A82 V83 F117 Y143 Y144 G145 VTVRRFRPEDLNKLAKCNLDPFTETYELGFYLQYYAKWPSLFQVAEDQHGNIIGYIMGKLESSPDVYRFSPHYLPWHAHITAVTVAPEARRMGIGRLLTEQLEAAADAADAWFVDLFVRTTNHKAIAFYKSMGYSVYRVVKDYYGDHSADPSRSSEDAYDMRKPMKRDVKREHIREDGEKHEVDPSVVWH 6zmp A 1.57 BS02 CMC C 1 D21 F23 T24 A83 V84 T85 V86 R91 R92 M93 G94 G96 R97 L117 F118 V119 N123 K125 A126 A128 F129 Y130 S132 D20 F22 T23 A82 V83 T84 V85 R90 R91 M92 G93 G95 R96 L116 F117 V118 N122 K124 A125 A127 F128 Y129 S131 VTVRRFRPEDLNKLAKCNLDPFTETYELGFYLQYYAKWPSLFQVAEDQHGNIIGYIMGKLESSPDVYRFSPHYLPWHAHITAVTVAPEARRMGIGRLLTEQLEAAADAADAWFVDLFVRTTNHKAIAFYKSMGYSVYRVVKDYYGDHSADPSRSSEDAYDMRKPMKRDVKREHIREDGEKHEVDPSVVWH 6zmp B 1.57 BS01 III D 1 F23 T24 E25 T26 Y27 E28 H80 T82 A83 V84 F118 Y144 Y145 G146 F22 T23 E24 T25 Y26 E27 H79 T81 A82 V83 F117 Y143 Y144 G145 VTVRRFRPEDLNKLAKCNLDPFTETYELGFYLQYYAKWPSLFQVAEDQHGNIIGYIMGKLESSPDVYRFSPHYLPWHAHITAVTVAPEARRMGIGRLLTEQLEAAADAADAWFVDLFVRTTNHKAIAFYKSMGYSVYRVVKDYYGDHSADPSRSSEDAYDMRKPMKRDVKREHIREDGEKHEVDPSVVWH 6zmp B 1.57 BS02 CMC D 1 D21 T24 A83 V84 T85 V86 R91 R92 M93 G94 G96 R97 L117 F118 V119 N123 K125 A126 A128 F129 Y130 S132 D20 T23 A82 V83 T84 V85 R90 R91 M92 G93 G95 R96 L116 F117 V118 N122 K124 A125 A127 F128 Y129 S131 VTVRRFRPEDLNKLAKCNLDPFTETYELGFYLQYYAKWPSLFQVAEDQHGNIIGYIMGKLESSPDVYRFSPHYLPWHAHITAVTVAPEARRMGIGRLLTEQLEAAADAADAWFVDLFVRTTNHKAIAFYKSMGYSVYRVVKDYYGDHSADPSRSSEDAYDMRKPMKRDVKREHIREDGEKHEVDPSVVWH 6zq4 A 2.02 BS01 GOL A 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGAREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq4 B 2.02 BS01 GOL B 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGGREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq4 C 2.02 BS01 GOL C 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAAREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq4 D 2.02 BS01 GOL D 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq4 E 2.02 BS01 GOL E 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGGAREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq4 F 2.02 BS01 GOL F 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGGNAREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq4 G 2.02 BS01 GOL G 1 R148 E149 W168 D317 Q318 R84 E85 W104 D253 Q254 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGGNAREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq4 H 2.02 BS01 GOL H 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGGAREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq6 A 2.30 BS01 GOL A 1 R148 E149 W168 D317 F342 R84 E85 W104 D253 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGAREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq6 B 2.30 BS01 GOL B 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGGREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq6 C 2.30 BS01 GOL C 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq6 D 2.30 BS01 GOL D 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq6 D 2.30 BS02 GOL D 2 W154 S156 Y236 H249 W90 S92 Y172 H185 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGREVFYPKMDRKKAERLFRKWEQAVEMSRGWVRE 6zq7 A 2.42 BS01 GOL A 1 R148 E149 W168 D317 Q318 F342 R84 E85 W104 D253 Q254 F278 GSFVGSIDQGTTSSRFLIFNGEGNPVASHQIEFENLYPKSGWHEQDPYELLNSVQQCIDGAMHKFASLGYSKENIRAIGITNQRETTVVWDSVTGEPLHNAIVWPDTRTSALVRELKARQSADSLLELCGLPLSTYPSSVKLLWLIQNVDAVKQAYEEGRLAFGTVDSWLIYKLNGGAQAERPIHVTDSTNASRTMFMNLRTLQYDDKLLGFFGIDRNKIKLPKIVPSSDPEAFGKVATGALAGVPIAGCLGDQSSALVGQCGFSPGQAKNTYGTGCFLLYNVGTEPVISKYGLLATVAYDFGRGRKPVYALEGSIAVAGAGITFLMNNLGFAPKPSEINALAESVLDNGGVVFVTAFSGLFAPYWIDDAKGTLFGITQHTTKGHIARATLEATCYQTRAILDAMEKDSGHKLESLAVDGGLSASDLCMQTQADISGIPVDRPRMRETTALGAAIAAGLATGVWRELDHVKESIAGGREVFYPKMDRKKAERLFRKWEQAVEMSRGWVR 6zwb A 1.75 BS01 GTP A 1 G10 Q11 A12 Q15 I16 D98 A99 N101 S140 G143 G144 T145 G146 I171 V177 T179 E183 N206 Y224 L227 N228 I231 G10 Q11 A12 Q15 I16 D98 A99 N101 S140 G143 G144 T145 G146 I171 V177 T179 E183 N206 Y224 L227 N228 I231 33275880 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGV 6zwb A 1.75 BS02 QRN B 1 T179 A180 V181 T179 A180 V181 33275880 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGV 6zwb B 1.75 BS01 GDP B 1 G10 Q11 C12 Q15 S140 G143 G144 T145 G146 V171 P173 V177 S178 E183 N206 L209 Y224 L227 N228 V231 G10 Q11 C12 Q15 S138 G141 G142 T143 G144 V169 P171 V175 S176 E181 N204 L207 Y222 L225 N226 V229 33275880 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 6zwb B 1.75 BS02 QRN B 1 V238 L242 L248 A250 K254 L255 N258 M259 V315 I318 N350 K352 V236 L240 L246 A248 K252 L253 N256 M257 V313 I316 N348 K350 33275880 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 6zwc A 2.04 BS01 GTP A 1 G10 Q11 A12 Q15 D98 A99 N101 S140 G143 G144 T145 G146 T179 E183 N206 Y224 N228 I231 G10 Q11 A12 Q15 D98 A99 N101 S140 G143 G144 T145 G146 T179 E183 N206 Y224 N228 I231 33275880 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVG 6zwc B 2.04 BS01 GDP B 1 G10 Q11 C12 Q15 S140 G143 G144 T145 G146 V177 E183 N206 Y224 N228 G10 Q11 C12 Q15 S138 G141 G142 T143 G144 V175 E181 N204 Y222 N226 33275880 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 6zwc B 2.04 BS02 QRQ B 1 C241 L242 D251 L255 N258 M259 V315 I318 N350 K352 A354 I378 C239 L240 D249 L253 N256 M257 V313 I316 N348 K350 A352 I368 33275880 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 6zz1 A 1.64 BS01 QOK A 1 Y23 C24 R82 I85 C86 L89 D144 F148 Y24 C25 R81 I84 C85 L88 D138 F142 33318170 PGENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPQGASWAQEDQQDADEDRRAFQM 6zz1 B 1.64 BS01 QOK B 1 Y23 C24 R82 I85 C86 L89 D144 F148 Y24 C25 R79 I82 C83 L86 D135 F139 33318170 PGENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPGASWAQEDQQDADEDRRAFQ 7apv A 1.95 BS01 9F2 A 1 H33 H35 D37 H38 H115 D136 T167 F168 N205 C206 K207 K288 P289 S290 T291 H319 H30 H32 D34 H35 H112 D133 T164 F165 N202 C203 K204 K285 P286 S287 T288 H316 3.1.-.- FEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRS 7apv A 1.95 BS02 ZN A 1 H228 H254 C256 C272 H225 H251 C253 C269 3.1.-.- FEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRS 7aqu A 1.63 BS01 GLY A 1 F159 D161 F154 D156 DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPIGVGEATIPNLQRAFFDYLGIPEEEWMRECNASYKMAIKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESTGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNSNYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGA 7aqu A 1.63 BS02 GLY A 2 P53 Y454 Y455 E461 F465 N470 P48 Y449 Y450 E456 F460 N465 DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPIGVGEATIPNLQRAFFDYLGIPEEEWMRECNASYKMAIKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESTGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNSNYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGA 7aqu A 1.63 BS03 ALA A 1 Y409 F410 K423 Y404 F405 K418 DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPIGVGEATIPNLQRAFFDYLGIPEEEWMRECNASYKMAIKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESTGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNSNYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGA 7aqu A 1.63 BS04 SER A 1 N3 D378 N2 D373 DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPIGVGEATIPNLQRAFFDYLGIPEEEWMRECNASYKMAIKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESTGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNSNYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGA 7aqu B 1.63 BS01 GLY B 1 N30 V32 I34 Q189 A190 N29 V31 I33 Q188 A189 DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATIPNLQRAFFDYLGIPEEEWMRECNASYKMAIKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESTGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPGTYYNFEAEFRNFWTNSNYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHG 7aqu B 1.63 BS02 GLY B 2 G14 W18 E38 S175 A178 A179 R182 G13 W17 E37 S174 A177 A178 R181 DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATIPNLQRAFFDYLGIPEEEWMRECNASYKMAIKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESTGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPGTYYNFEAEFRNFWTNSNYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHG 7aqu B 1.63 BS03 GLY B 3 L11 L37 E38 A39 D196 E197 M198 L10 L36 E37 A38 D195 E196 M197 DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATIPNLQRAFFDYLGIPEEEWMRECNASYKMAIKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESTGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPGTYYNFEAEFRNFWTNSNYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHG 7aqu B 1.63 BS04 GLY B 4 T15 E49 L349 G361 I362 T14 E48 L348 G360 I361 DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATIPNLQRAFFDYLGIPEEEWMRECNASYKMAIKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESTGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPGTYYNFEAEFRNFWTNSNYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHG 7as9 0 3.50 BS01 NUC 2 1 F3 D4 P54 R98 E121 M123 R125 H126 S127 N128 K144 L146 M150 N151 S152 R154 P165 P166 Q168 K170 V197 D198 P205 Q289 Q290 D293 R296 K430 R433 F1 D2 P52 R96 E119 M121 R123 H124 S125 N126 K142 L144 M148 N149 S150 R152 P163 P164 Q166 K168 V190 D191 P198 Q276 Q277 D280 R283 K414 R417 FDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAKGKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIMIFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLPGQDYKLPPAQDKISPDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRATLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELLDRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELLTANLYMLKKGDKQAEVINYESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVVEEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPHNPVLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQTIMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPKPGFVTYDSQHTVFVTPDADTVI 7as9 H 3.50 BS01 NUC B 1 D23 S24 M26 Q27 Q63 K64 T90 R92 D22 S23 M25 Q26 Q62 K63 T89 R91 NRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAVQNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDKLISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQKVRGMDIVIVTTANTDEEARELLTQVGMPF 7as9 Q 3.50 BS01 NUC B 1 K16 M17 R18 G19 K16 M17 R18 G19 MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITNRQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKVLFEISGVSEEVAREALRLASHKLPIKTKFVKRE 7as9 S 3.50 BS01 NUC B 1 K7 R11 H15 R30 N32 F34 R35 S36 N37 K38 H39 Y41 Q43 T52 S55 L59 Y100 L101 H103 G104 R105 K7 R11 H15 R30 N32 F34 R35 S36 N37 K38 H39 Y41 Q43 T52 S55 L59 Y100 L101 H103 G104 R105 MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQIIDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLYHGRVKALADAAREAGLKF 7as9 a 3.50 BS01 NUC B 1 R79 G81 R82 R62 G64 R65 TKNGRDSEAKRLGAKRADGQFVTGGSILYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPV 7as9 d 3.50 BS01 NUC B 1 R15 H52 R14 H51 AKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIRGMINKVSHLVSVKEQ 7asa 0 3.50 BS01 NUC 2 1 K32 H33 H53 P54 S55 D97 R98 M123 R125 H126 S149 M150 N151 S152 P166 Q168 G202 S204 P205 R286 Q289 Q290 D293 K31 H32 H52 P53 S54 D96 R97 M122 R124 H125 S148 M149 N150 S151 P165 Q167 G196 S198 P199 R274 Q277 Q278 D281 SFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAKGKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIMIFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLPGQDYKLPPAQDKISPDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRATLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELLDRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELLTANLYMLKKGDKQAEVINYESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVVEEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPHNPVLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQTIMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPKPGFVTYDSQHTVFVTPDADTVI 7asa 0 3.50 BS02 NUC A 1 Q326 E330 T333 L336 K341 G342 P365 N366 S370 Q374 F377 Y380 K384 Q314 E318 T321 L324 K329 G330 P350 N351 S355 Q359 F362 Y365 K369 SFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAKGKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIMIFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLPGQDYKLPPAQDKISPDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRATLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELLDRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELLTANLYMLKKGDKQAEVINYESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVVEEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPHNPVLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQTIMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPKPGFVTYDSQHTVFVTPDADTVI 7asa 1 3.50 BS01 NUC 2 1 R11 T67 K68 K69 R11 T67 K68 K69 MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPGDELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEK 7asa K 3.50 BS01 NUC A 1 Q12 P74 A75 K80 S87 G88 S89 G90 E91 P92 N93 R94 K112 D115 L116 N117 M127 G130 T131 R133 S134 M135 Q3 P65 A66 K71 S78 G79 S80 G81 E82 P83 N84 R85 K103 D106 L107 N108 M118 G121 T122 R124 S125 M126 KLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKRDKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIE 7atu A 2.80 BS01 RXN A 1 F350 A353 V366 K368 M388 L391 V396 L397 F399 F411 T413 L451 I456 H458 D478 F479 R483 F15 A18 V31 K33 M53 L56 V61 L62 F64 F74 T76 L114 I119 H121 D141 F142 R146 2.7.11.1 MPHRIFGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRR 7atu B 2.80 BS01 RXN B 1 A353 V366 K368 M388 L391 V396 L397 F399 F411 T413 L451 H458 D478 F479 R483 A25 V38 K40 M60 L63 V68 L69 F71 F83 T85 L123 H130 D150 F151 R155 2.7.11.1 MPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMRYTVVGNPYWMAPEMINRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGE 7atu C 2.80 BS01 RXN C 1 A353 V366 K368 M388 L391 V396 L397 F399 F411 T413 L451 I456 H458 V476 A477 D478 F479 R483 A4 V8 K10 M30 L33 V38 L39 F41 F49 T51 L89 I94 H96 V114 A115 D116 F117 R121 2.7.11.1 FGQAIVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETY 7atu D 2.80 BS01 RXN D 1 K368 M388 V396 L397 F399 F411 T413 L451 H458 A477 D478 F479 L481 R483 K13 M31 V39 L40 F42 F50 T52 L90 H97 A116 D117 F118 L120 R122 2.7.11.1 IKVTHTGEVMVMKERFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMGNPYWMAPEMINGYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLGHLPLGPQLEQLDRGFWETY 7ayn A 1.42 BS01 SBQ A 1 F1 I13 N46 D47 Y48 I52 D54 Q133 N135 Y137 D140 F142 F1 I13 N46 D47 Y48 I52 D54 Q133 N135 Y137 D140 F142 FACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSATDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPT 7ayn B 1.42 BS01 SBQ B 1 F1 I13 N46 D47 Y48 I52 D54 Q133 N135 Y137 D140 F142 F1 I13 N46 D47 Y48 I52 D54 Q133 N135 Y137 D140 F142 FACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSATDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPT 7ayn C 1.42 BS01 SBQ C 1 F1 I13 N46 D47 Y48 I52 D54 Q133 N135 Y137 D140 F142 F1 I13 N46 D47 Y48 I52 D54 Q133 N135 Y137 D140 F142 FACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSATDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPT 7ayn D 1.42 BS01 SBQ D 1 F1 I13 N46 D47 Y48 I52 D54 Q133 N135 Y137 D140 F142 F1 I13 N46 D47 Y48 I52 D54 Q133 N135 Y137 D140 F142 FACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSATDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPT 7b3b A 3.10 BS01 NUC P 1 R513 D760 C813 S814 R836 A840 K849 R858 S861 D865 R411 D658 C711 S712 R734 A738 K747 R756 S759 D763 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3b A 3.10 BS02 NUC T 1 N496 K500 S501 N507 Q541 N543 K545 A558 G559 R569 K577 A580 G590 S592 F594 Y595 S682 G683 D684 A685 Y689 Y915 M924 N394 K398 S399 N405 Q439 N441 K443 A456 G457 R467 K475 A478 G488 S490 F492 Y493 S580 G581 D582 A583 Y587 Y800 M809 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3b A 3.10 BS03 ZN A 1 H295 C301 C306 C310 H198 C204 C209 C213 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3b A 3.10 BS04 ZN A 2 C487 H642 C645 C646 C385 H540 C543 C544 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3c A 3.40 BS01 NUC P 1 S682 L758 S759 D760 C813 S814 R836 A840 K849 R858 S861 S580 L656 S657 D658 C711 S712 R734 A738 K747 R756 S759 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3c A 3.40 BS02 NUC T 1 N496 K500 S501 N507 N543 V557 A558 G559 R569 K577 A580 G590 S592 F594 Y595 S682 G683 D684 A685 T687 Y689 E857 N394 K398 S399 N405 N441 V455 A456 G457 R467 K475 A478 G488 S490 F492 Y493 S580 G581 D582 A583 T585 Y587 E755 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3c A 3.40 BS03 ZN A 1 H295 C301 C306 C310 H198 C204 C209 C213 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3c A 3.40 BS04 ZN A 2 C487 H642 C645 C646 C385 H540 C543 C544 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3d A 2.80 BS01 NUC P 1 R513 L758 S759 D760 C813 S814 R836 A840 L854 R858 S861 D865 R411 L656 S657 D658 C711 S712 R734 A738 L752 R756 S759 D763 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3d A 2.80 BS02 NUC T 1 N496 K500 S501 N507 Q541 N543 K545 V557 A558 G559 R569 K577 G590 S592 F594 Y595 S682 G683 D684 A685 Y689 E857 S861 R914 Y915 M924 N394 K398 S399 N405 Q439 N441 K443 V455 A456 G457 R467 K475 G488 S490 F492 Y493 S580 G581 D582 A583 Y587 E755 S759 R799 Y800 M809 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3d A 2.80 BS03 ZN A 1 H295 C301 C306 C310 H198 C204 C209 C213 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b3d A 2.80 BS04 ZN A 2 C487 H642 C645 C646 C385 H540 C543 C544 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRYWEPEFYEAMYTPHT 7b60 A 1.91 BS01 O3D A 1 M141 N146 D164 V165 E168 M182 E183 V184 S185 R193 V194 M138 N143 D156 V157 E160 M174 E175 V176 S177 R185 V186 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b60 A 1.91 BS02 O3D A 2 W226 Y229 S230 C234 L253 W218 Y221 S222 C226 L245 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b60 B 1.91 BS01 O3D B 1 M141 G142 T143 D164 V165 M182 E183 V184 S185 R193 V194 M136 G137 T138 D154 V155 M172 E173 V174 S175 R183 V184 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b68 A 1.89 BS01 LVV A 1 F204 W226 Y229 S230 C234 W249 L253 F201 W223 Y226 S227 C231 W246 L250 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b68 A 1.89 BS02 LVV A 2 M141 N146 T155 T158 G160 D164 V165 E168 M182 E183 S185 G188 V194 M138 N143 T152 T155 G157 D161 V162 E165 M179 E180 S182 G185 V191 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b68 B 1.89 BS01 LVV B 1 F204 W226 Y229 S230 C234 W249 L253 F194 W208 Y211 S212 C216 W231 L235 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b68 B 1.89 BS02 LVV B 2 M141 N146 G160 D164 V165 M182 E183 S185 G188 V194 M136 N141 G150 D154 V155 M172 E173 S175 G178 V184 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6i B 2.07 BS01 SZE B 1 T115 S202 V203 F204 K225 W226 Y229 I239 W249 T110 S192 V193 F194 K206 W207 Y210 I220 W230 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6j A 2.09 BS01 SZB A 1 F204 Y229 I239 V245 W249 F196 Y221 I231 V237 W241 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6j A 2.09 BS02 SZB A 2 L27 D28 S29 R30 Y51 L24 D25 S26 R27 Y48 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6j B 2.09 BS01 SZB B 1 F204 I239 V245 W249 F194 I221 V227 W231 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6k A 1.84 BS01 SZ2 A 1 T115 S202 F204 W226 Y229 S230 W249 T112 S194 F196 W211 Y214 S215 W234 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6k B 1.84 BS01 SZ2 B 1 T115 F204 W226 Y229 S230 A237 W249 T110 F194 W208 Y211 S212 A219 W231 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6l A 2.08 BS01 SZK A 1 T115 L189 S202 V203 F204 K225 L228 Y229 A237 I239 W249 T112 L181 S194 V195 F196 K217 L220 Y221 A229 I231 W241 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6l B 2.08 BS01 SZK B 1 T115 L189 S202 V203 F204 K225 L228 Y229 H232 A237 I239 W249 T112 L181 S194 V195 F196 K208 L211 Y212 H215 A220 I222 W232 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6m B 1.67 BS01 SZN B 1 G113 T115 L189 F199 S202 F204 Y229 H232 C234 V245 W249 G108 T110 L179 F189 S192 F194 Y211 H214 C216 V227 W231 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6n B 1.79 BS01 SYZ B 1 G113 T115 L189 F199 S202 F204 H232 C234 I239 V245 W249 G108 T110 L179 F189 S192 F194 H214 C216 I221 V227 W231 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6p A 1.68 BS01 9JT A 1 G113 T115 V184 L189 F199 S202 F204 Y229 H232 C234 I239 W249 G110 T112 V176 L181 F191 S194 F196 Y214 H217 C219 I224 W234 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNSHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVSGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTSAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6p B 1.68 BS01 9JT B 1 G113 T115 V184 L189 F199 S202 F204 Y229 H232 C234 I239 W249 G108 T110 V174 L179 F189 S192 F194 Y211 H214 C216 I221 W231 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNSHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVSGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTSAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b6q B 1.82 BS01 WZD B 1 T115 L189 S202 V203 F204 L228 Y229 A237 I239 W249 T110 L179 S192 V193 F194 L209 Y210 A218 I220 W230 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b9e A 2.12 BS01 JHP A 1 T115 L189 S202 L228 Y229 H232 C234 A237 W249 T112 L181 S194 L213 Y214 H217 C219 A222 W234 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7b9e B 2.12 BS01 JHP B 1 L189 S202 V203 F204 L228 Y229 H232 C234 I239 W249 L179 S192 V193 F194 L209 Y210 H213 C215 I220 W230 6.3.2.13 RNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA 7br0 A 2.00 BS01 FAD A 1 G16 G17 G18 I19 A20 D39 E40 G41 I42 H43 R44 N45 A48 L51 A52 T53 V85 L87 A120 M121 G122 D125 W137 T138 H143 H147 R252 F255 G287 D288 K294 I295 G296 G12 G13 G14 I15 A16 D35 E36 G37 I38 H39 R40 N41 A44 L47 A48 T49 V81 L83 A116 M117 G118 D121 W133 T134 H139 H143 R248 F251 G283 D284 K290 I291 G292 SSIPLYDCLIIGGGIAGLSSALSLVRTLHTAVVFDEGIHRNDQAPHLATVPTWDSQDPKRFRDAAKLNILSKYSTVEFANVKLEKVNQLTDGPYKGYFCVWDTKQRQWLGRKVILAMGVEDLLPTIDGFAECWTKGIFHCLVHRGYEERGSASGGVLAIDGDATFFAARHLAFQARNLTDHVVIYTHGNDELAQEVESQLGPCGFRAESRRIEKLVQHPERAQMEVHFEDGQSETVGFIVHRPRTSIRGPFAEQLGVEMTPEGHIKTQFPFNETTVSGVFVAGDAGSQFKIGTQAVVMGAFAAGGVQMQVNAEKWSQP 7bx9 A 1.38 BS01 FMN A 1 T9 R11 G14 R15 T16 P72 E73 Y74 H75 S76 A104 A105 G106 G110 T10 R12 G15 R16 T17 P73 E74 Y75 H76 S77 A105 A106 G107 G111 33289153 MMSILVISGTPRKNGRTRIAASYIRDRFHTDFIDLSESELPLYNGEEEQNELPSVQALRRQVKKSAAVVLLSPEYHSGMSGALKNAIDFLSSDHWAYKPVAIIAAAGGGKGGMNALANMRTVMRGVYANVIPKQLVLDPIHIDMERRTVSEDMAVSLKDMIEELNMFT 7c7l A 3.00 BS01 NUC C 1 T7 K8 T9 K11 R13 V15 R16 K31 R66 N67 C72 K76 D79 Y82 R86 F94 W95 S99 Y113 K165 N169 S180 G181 P183 T184 T185 P191 D213 S255 T256 Q257 R258 R259 R261 N262 T271 E272 E289 K291 K295 K299 S300 N305 S307 H353 K357 R363 L365 L366 K367 K368 K372 R373 A374 G375 H376 G377 A378 K379 N380 K381 L382 K383 K391 R394 F395 K397 K398 E401 C405 F454 K455 T5 K6 T7 K9 R11 V13 R14 K29 R53 N54 C59 K63 D66 Y69 R73 F81 W82 S86 Y100 K152 N156 S167 G168 P170 T171 T172 P178 D200 S242 T243 Q244 R245 R246 R248 N249 T258 E259 E276 K278 K282 K286 S287 N292 S294 H340 K344 R350 L352 L353 K354 K355 K359 R360 A361 G362 H363 G364 A365 K366 N367 K368 L369 K370 K378 R381 F382 K384 K385 E388 C392 F438 K439 KNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALKEACSKHLKVTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKIGEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNADYNAALNISNPKLK 7c7l A 3.00 BS02 NUC D 1 T7 R163 K167 S168 R171 Q197 K198 Y202 S286 Y287 S307 L382 T386 T389 E393 L424 K428 W443 P444 Y445 A446 T5 R150 K154 S155 R158 Q184 K185 Y189 S273 Y274 S294 L369 T373 T376 E380 L411 K415 W427 P428 Y429 A430 KNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALKEACSKHLKVTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKIGEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNADYNAALNISNPKLK 7c7l A 3.00 BS03 NUC E 1 I131 A132 N133 S135 S136 H139 Y140 S142 Y146 A156 R163 K173 K176 N177 K179 K196 Q242 V243 Q244 I118 A119 N120 S122 S123 H126 Y127 S129 Y133 A143 R150 K160 K163 N164 K166 K183 Q229 V230 Q231 KNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALKEACSKHLKVTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKIGEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNADYNAALNISNPKLK 7c7l A 3.00 BS04 ZN A 1 C50 H53 C69 C72 C41 H44 C56 C59 KNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALKEACSKHLKVTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKIGEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNADYNAALNISNPKLK 7c7l A 3.00 BS05 ZN A 2 C475 C478 C500 C503 C459 C462 C484 C487 KNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALKEACSKHLKVTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKIGEKSAWMLNLSIDVPKIDKGVDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNADYNAALNISNPKLK 7c7l B 3.00 BS01 NUC C 1 K8 E138 K167 K173 E174 N177 K186 K330 F341 D348 F352 H353 F354 K356 K357 F359 A360 R361 R363 I364 K391 R394 F395 R438 K491 K4 E58 K87 K93 E94 N97 K106 K195 F206 D213 F217 H218 F219 K221 K222 F224 A225 R226 R228 I229 K241 R244 F245 R288 K341 TITKTLKLRIVRPFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVFEISNFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSYIEVKRGSSAWMLNLSIDVPDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENADYNAALNISNPKL 7c7l B 3.00 BS02 NUC D 1 T9 K11 M303 N305 F341 S342 R343 Y344 S345 T5 K7 M174 N176 F206 S207 R208 Y209 S210 TITKTLKLRIVRPFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVFEISNFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSYIEVKRGSSAWMLNLSIDVPDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENADYNAALNISNPKL 7c7l B 3.00 BS03 NUC E 1 Y232 P234 W235 K237 R292 Y139 P141 W142 K144 R168 TITKTLKLRIVRPFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVFEISNFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSYIEVKRGSSAWMLNLSIDVPDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENADYNAALNISNPKL 7c7l B 3.00 BS04 ZN B 1 C475 C478 C500 C503 C325 C328 C350 C353 TITKTLKLRIVRPFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVFEISNFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSYIEVKRGSSAWMLNLSIDVPDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENADYNAALNISNPKL 7cko A 2.95 BS01 G5L A 1 Y34 K38 Y70 M151 S154 P155 F274 F278 D309 F367 S371 F375 Y19 K23 Y55 M136 S139 P140 F200 F204 D235 F293 S297 F301 GGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLA 7ckr A 3.00 BS01 G5O A 1 Y34 P37 K38 Y70 M151 S154 F278 V282 R313 F367 S371 V402 P406 Y19 P22 K23 Y55 M136 S139 F211 V215 R246 F300 S304 V335 P339 GGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLA 7cmh B 3.40 BS01 TRP B 1 I53 G55 S56 G57 N134 F243 A244 G246 V391 N395 I13 G15 S16 G17 N94 F203 A204 G206 V351 N355 33298890 GLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEV 7cmi B 2.90 BS01 LEU B 1 I53 G55 S56 G57 N134 F243 A244 G246 I13 G15 S16 G17 N94 F203 A204 G206 33298890 GLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEV 7d6m A 1.89 BS01 SAM A 1 S56 G58 G81 C82 G83 G86 W87 T104 I105 H110 M130 D131 V132 F133 D146 I147 S51 G53 G76 C77 G78 G81 W82 T99 I100 H105 M125 D126 V127 F128 D141 I142 MTLGDLWKRKLNGCTKEEFFAYRRTGILETERDKARELLRRGETNMGLAVSRGTAKLAWLEERGYATLKGEVVDLGCGRGGWSYYAASRPAVMSVKAYTIGGKGHETPKMVTSLGWNLIKFRAGMDVFSMQPHRADTIMCDIGESNPDAVVEGERTRKVILLMEQWKNRNPTATCVFKVLAPYRPEVIEALHRFQLQWGGGLVRTPFSRNSTHEMYYSTAVTGNIVNSVNIQSRKLLARFGDQRGPTRVPELDLGVGTRG 7d6m B 1.89 BS01 SAM B 1 S56 G58 G81 C82 G83 G86 W87 T104 I105 H110 M130 D131 V132 F133 D146 I147 S51 G53 G76 C77 G78 G81 W82 T99 I100 H105 M125 D126 V127 F128 D141 I142 MTLGDLWKRKLNGCTKEEFFAYRRTGILETERDKARELLRRGETNMGLAVSRGTAKLAWLEERGYATLKGEVVDLGCGRGGWSYYAASRPAVMSVKAYTIGGKGHETPKMVTSLGWNLIKFRAGMDVFSMQPHRADTIMCDIGESNPDAVVEGERTRKVILLMEQWKNRNPTATCVFKVLAPYRPEVIEALHRFQLQWGGGLVRTPFSRNSTHEMYYSTAVTGNIVNSVNIQSRKLLARFGDQRGPTRVPELDLGVGTRG 7d6n A 3.17 BS01 ZN A 1 H715 C729 C848 H415 C429 C547 2.7.7.49 DKVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRWSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMDR 7d6n A 3.17 BS02 ZN A 2 E439 H443 C448 C451 E159 H163 C168 C171 2.7.7.49 DKVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRWSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMDR 7d6n A 3.17 BS03 MG A 1 A533 D535 D665 P708 A233 D235 D365 P408 2.7.7.49 DKVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRWSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMDR 7d6n B 3.17 BS01 ZN B 1 H715 C729 C848 H414 C428 C545 2.7.7.49 DKVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCM 7d6n B 3.17 BS02 ZN B 2 E439 H443 C448 C451 E158 H162 C167 C170 2.7.7.49 DKVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCM 7d6n B 3.17 BS03 MG B 1 A533 D535 D665 C666 P708 A232 D234 D364 C365 P407 2.7.7.49 DKVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCM 7d6n E 3.17 BS01 ZN E 1 H715 C729 C848 H415 C429 C548 2.7.7.49 DKVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNSSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMIWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n E 3.17 BS02 ZN E 2 E439 H443 C448 C451 E157 H161 C166 C169 2.7.7.49 DKVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNSSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMIWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n E 3.17 BS03 MG E 1 A533 D535 D665 C666 P708 A233 D235 D365 C366 P408 2.7.7.49 DKVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNSSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMIWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n D 3.17 BS01 ZN D 1 H715 C729 C848 H416 C430 C549 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRWSSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n D 3.17 BS02 ZN D 2 E439 H443 C448 C451 E159 H163 C168 C171 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRWSSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n D 3.17 BS03 MG D 1 A533 D535 D665 C666 P708 A234 D236 D366 C367 P409 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRWSSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n C 3.17 BS01 ZN C 1 H715 C729 C848 H415 C429 C548 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMIWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n C 3.17 BS02 ZN C 2 E439 H443 C448 C451 E157 H161 C166 C169 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMIWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n C 3.17 BS03 MG C 1 A533 D535 D665 P708 A233 D235 D365 P408 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMIWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n F 3.17 BS01 ZN F 1 H715 C729 C848 H412 C426 C545 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSLVRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n F 3.17 BS02 ZN F 2 E439 H443 C448 C451 E155 H159 C164 C167 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSLVRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n F 3.17 BS03 MG F 1 A533 D535 D665 P708 A230 D232 D362 P405 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSLVRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n G 3.17 BS01 ZN G 1 H715 C729 C848 H411 C425 C544 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n G 3.17 BS02 ZN G 2 E439 H443 C448 C451 E155 H159 C164 C167 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n G 3.17 BS03 MG G 1 A533 D535 D665 C666 P708 A229 D231 D361 C362 P404 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n J 3.17 BS01 ZN J 1 H715 C729 C848 H409 C423 C542 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n J 3.17 BS02 ZN J 2 E439 H443 C448 C451 E153 H157 C162 C165 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n J 3.17 BS03 MG J 1 A533 D535 D665 C666 P708 A227 D229 D359 C360 P402 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n I 3.17 BS01 ZN I 1 H715 C729 C848 H413 C427 C546 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n I 3.17 BS02 ZN I 2 E439 H443 C448 C451 E156 H160 C165 C168 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n I 3.17 BS03 MG I 1 A533 D535 D665 P708 A231 D233 D363 P406 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n H 3.17 BS01 ZN H 1 H715 C729 C848 H415 C429 C548 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMIWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n H 3.17 BS02 ZN H 2 E439 H443 C448 C451 E157 H161 C166 C169 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMIWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d6n H 3.17 BS03 MG H 1 A533 D535 D665 P708 A233 D235 D365 P408 2.7.7.49 KVKEKDVQERISALREQYGETWHMDREHPYRTWQYWGSYRTAPTGSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTKVIMRAVNDWILERLARKSKPRMCSREEFIAKVKSNQNRSAKEAVEDPAFWQLVDEERERHLAGRCAHCVYNMMIWYMWLGSRFLEFEALGFLNEDHWASRGSSGSGVEGISLNYLGWYLKGLSTLEGGLFYADDTAGWDTKVTNADLEDEEQLLRYMEGEHKQLAATIMQKAYHAKVVKVARPSRDGGCVMDVITRRDQRGSGQVVTYALNTLTNIKVQLIRMMEGEGVIEASDAHNPRLLRVERWLRDHGEERLGRMLVSGDDCVVRPVDDRFSRALYFLNDMAKTRKDIGEWEHSVGFSNWEEVPFCSHHFHELVMKDGRALIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLAICSAVPIDWVPTGRTTWSIHASGAWMTTEDMLDVWNRVWILDNPFMHSKEKIVEWRDVPYLPKSHDMLCSSLVGRKERAEWAKNIWGAVEKVRKMIGQEKFKDYLSCMD 7d8j B 2.88 BS01 URF B 1 T12 K13 F48 T12 K13 F48 MLNRVVLVGRLTKDPELRSTPNGVNVGTFTLAVNRTFTNAQGEREADFINVVVFKKQAENVKNYLSKGSLAGVDGRLQTRNYVFVTEVVADSVQFLEP 7dbp K 4.50 BS01 NUC I 1 R27 Q28 Q31 N43 R27 Q28 Q31 N43 KSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAK 7dbp K 4.50 BS02 NUC J 1 K7 Y8 S26 Q28 S29 Q47 S72 K7 Y8 S26 Q28 S29 Q47 S72 KSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAK 7dbp A 4.50 BS01 NUC I 1 R40 T45 R63 R72 R83 Q85 V117 T118 M120 R3 T8 R26 R35 R46 Q48 V80 T81 M83 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 7dbp A 4.50 BS02 NUC J 1 Y41 R49 R63 Y4 R12 R26 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 7dbp B 4.50 BS01 NUC I 1 P32 R36 P13 R17 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 7dbp B 4.50 BS02 NUC J 1 R35 I46 K79 R16 I27 K60 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 7dbp C 4.50 BS01 NUC I 1 K15 T16 R20 R32 R42 R77 K2 T3 R7 R19 R29 R64 AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 7dbp C 4.50 BS02 NUC J 1 R29 E41 R42 T76 R16 E28 R29 T63 AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 7dbp D 4.50 BS01 NUC I 1 S29 Y39 S52 T85 S3 Y13 S26 T59 KRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 7dbp D 4.50 BS02 NUC J 1 R28 R30 K31 R2 R4 K5 KRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 7dbp E 4.50 BS01 NUC I 1 Y41 P43 G44 R49 R63 L65 R83 Y4 P6 G7 R12 R26 L28 R46 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 7dbp E 4.50 BS02 NUC J 1 R40 R42 T45 R63 R72 R83 F84 T118 R3 R5 T8 R26 R35 R46 F47 T81 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 7dbp F 4.50 BS01 NUC I 1 R35 R45 I46 R78 K79 T80 R16 R26 I27 R59 K60 T61 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 7dbp F 4.50 BS02 NUC J 1 R36 R45 R17 R26 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 7dbp G 4.50 BS01 NUC I 1 R29 E41 R42 T76 R77 R14 E26 R27 T61 R62 TRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 7dbp G 4.50 BS02 NUC J 1 T16 R20 R32 R77 T1 R5 R17 R62 TRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 7dbp H 4.50 BS01 NUC I 1 R28 R30 K31 R2 R4 K5 KRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK 7dbp H 4.50 BS02 NUC J 1 S29 R30 Y39 T85 S3 R4 Y13 T59 KRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK 7dep A 3.09 BS01 URF A 1 K13 T30 F48 N50 K13 T30 F42 N44 MLNRVVLVGRLTKDPELRSTPNGVNVGTFTLAVNRTEREADFINVVVFKKQAENVKNYLSKGSLAGVDGRLQTRNYENKDGQRVFVTEVVADSVQFLEP 7dep B 3.09 BS01 URF B 1 K13 F48 K13 F48 MLNRVVLVGRLTKDPELRSTPNGVNVGTFTLAVNRTFTNAQGEREADFINVVVFKKQAENVKNYLSKGSLAGVDGRLQTRNYENRVFVTEVVADSVQFLEPK 7dk8 A 1.99 BS01 AMP A 1 S109 S110 I312 T314 M337 Y338 A339 S340 S341 Y360 V414 D416 F432 R435 K446 S87 S88 I289 T291 M314 Y315 A316 S317 S318 Y337 V383 D385 F401 R404 K415 6.3.2.- 33272567 EKLRFIDEMTTNVDAVQERVLGEILGRNAGTEYLTKCGLDGATDRAAFRAKVPVVSYDDLQPYIQRIANGDRSPILSTHPVSEFLTSSGTSAGERKLMPTIMDELDRRQLLYSLLMPVMNLYVPGLDKGKGLYFLFVKSETKTPGGLTARPVLTSYYKSDHFKNRPDPYHNYTSPTAAILCADAFQSMYAQMVCGLCQRNDVLRLGAVFASGLLRAIRFLQLNWEQLADDIESGELTPRVTDPSVREAVAAILLPDPELAKLIRAECSKGDWAGIITRVWPNTKYLDVIVTGAMAQYIPTLEFYSGGLPMACTMYASSECYFGLNLRPMCDPSEVSYTIMPNMGYFEFLPVDATQLVDLARVEVGREYELVITTYAGLNRYRVGDVLRVTGFHNAAPQFRFVRRKNVLLSIESDKTDEAELQRAVERASALLRPHGASVVEYTSQACTKRIPGHYVIYWELLTVVDADTLGRCCLEMEEALNTVYRQSRVADGSIGPLEIRVVRPGTFEELMDYAISRGASINQYKVPRCVTFPPIVELLDSRVVSSHFSPALPHWTP 7dm1 B 2.10 BS01 PO4 B 1 S35 T36 L37 G64 S65 D83 R162 S166 G167 D168 S18 T19 L20 G47 S48 D66 R145 S149 G150 D151 TVATTPASSPVTLAETGSTLLYPLFNLWGPAFHERYPNVTITAQGTGSGAGIAQAAAGTVNIGASDAYLSEGDMAAHKGLMNIALAISAQQVNYNLPGVSEHLKLNGKVLAAMYQGTIKTWDDPQIAALNPGVNLPGTAVVPLHRSDGSGDTFLFTQYLSKQDPEGWGKSPGFGTTVDFPAVPGALGENGNGGMVTGCAETPGCVAYIGISFLDQASQRGLGEAQLGNSSGNFLLPDAQSIQAAAAGFASKTPANQAISMIDGPAPDGYPIINYEYAIVNNRQKDAATAQTLQAFLHWAITDGNKASFLDQVHFQPLPPAVVKLSDALIATISS 7dm1 A 2.10 BS01 PO4 A 1 S35 T36 L37 G64 S65 D83 R162 S166 G167 D168 N208 S18 T19 L20 G47 S48 D66 R145 S149 G150 D151 N191 TVATTPASSPVTLAETGSTLLYPLFNLWGPAFHERYPNVTITAQGTGSGAGIAQAAAGTVNIGASDAYLSEGDMAAHKGLMNIALAISAQQVNYNLPGVSEHLKLNGKVLAAMYQGTIKTWDDPQIAALNPGVNLPGTAVVPLHRSDGSGDTFLFTQYLSKQDPEGWGKSPGFGTTVDFPAVPGALGENGNGGMVTGCAETPGCVAYIGISFLDQASQRGLGEAQLGNSSGNFLLPDAQSIQAAAAGFASKTPANQAISMIDGPAPDGYPIINYEYAIVNNRQKDAATAQTLQAFLHWAITDGNKASFLDQVHFQPLPPAVVKLSDALIATISS 7dm2 A 2.40 BS01 PO4 A 1 S35 T36 L37 G64 S65 D83 R162 S166 G167 D168 S18 T19 L20 G47 S48 D66 R145 S149 G150 D151 TVATTPASSPVTLAETGSTLLYPLFNLWGPAFHERYPNVTITAQGTGSGAGIAQAAAGTVNIGASDAYLSEGDMAAHKGLMNIALAISAQQVNYNLPGVSEHLKLNGKVLAAMYQGTIKTWDDPQIAALNPGVNLPGTAVVPLHRSDGSGDTFLFTQYLSKQDPEGWGKSPGFGTTVDFPAVPGALGENGNGGMVTGCAETPGCVAYIGISFLDQASQRGLGEAQLGNSSGNFLLPDAQSIQAAAAGFASKTPANQAISMIDGPAPDGYPIINYEYAIVNNRQKDAATAQTLQAFLHWAITDGNKASFLDQVHFQPLPPAVVKLSDALIATISS 7dmu A 3.20 BS01 ZN A 1 H374 E375 H378 E402 H356 E357 H360 E384 3.4.17.23,3.4.17.- STIEEQVETFLDNFNHKAEDLFYQSSLASWNYNTNITEENVQNMNIAGDKWSAFLKEQSTFAQMYPLQEIQHLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 7dmu C 3.20 BS01 ZN C 1 H374 E375 H378 E402 H357 E358 H361 E385 3.4.17.23,3.4.17.- QSTIEEQVETFLDNFNHKAEDLFYQSSLASWNYNTNITEENVQNMNIAGDKWSAFLKEQSTFAQMYPLQEIQHLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 7doo A 1.60 BS01 NXL A 1 C69 S70 K73 Y105 S130 N132 N170 V216 K234 T235 G236 T237 C40 S41 K44 Y76 S101 N103 N141 V187 K205 T206 G207 T208 3.5.2.6 28264560 APASFAALERAAGGRLGVCAIDTATGRRALHRADERFPFCSTFKAMLGAAVLAQSVAHPGLLQQRVTYGRSDLVNYSPVTERHVDTGMTVAELCAATIQYSDNTAANELMKRIGGPAAVTAYARSIGDDTFRLDRWETELNTALPGDLRDTTTPAAMAANLRVLVLGDALPPAQRAQLIEWLRGNKVGDKRIRAGVPTGWRVGDKTGTGDYGTTNDVGVLWPPSRAPIVLAVYYTQTRADAKAKDDVIAAATRIASATLA 7doo B 1.60 BS01 NXL B 1 C69 S70 K73 Y105 S130 N132 N170 V216 K234 T235 G236 T237 C40 S41 K44 Y76 S101 N103 N141 V187 K205 T206 G207 T208 3.5.2.6 28264560 APASFAALERAAGGRLGVCAIDTATGRRALHRADERFPFCSTFKAMLGAAVLAQSVAHPGLLQQRVTYGRSDLVNYSPVTERHVDTGMTVAELCAATIQYSDNTAANELMKRIGGPAAVTAYARSIGDDTFRLDRWETELNTALPGDLRDTTTPAAMAANLRVLVLGDALPPAQRAQLIEWLRGNKVGDKRIRAGVPTGWRVGDKTGTGDYGTTNDVGVLWPPSRAPIVLAVYYTQTRADAKAKDDVIAAATRIASATLA 7doo C 1.60 BS01 NXL C 1 C69 S70 K73 Y105 S130 N132 N170 V216 K234 T235 G236 T237 C40 S41 K44 Y76 S101 N103 N141 V187 K205 T206 G207 T208 3.5.2.6 28264560 APASFAALERAAGGRLGVCAIDTATGRRALHRADERFPFCSTFKAMLGAAVLAQSVAHPGLLQQRVTYGRSDLVNYSPVTERHVDTGMTVAELCAATIQYSDNTAANELMKRIGGPAAVTAYARSIGDDTFRLDRWETELNTALPGDLRDTTTPAAMAANLRVLVLGDALPPAQRAQLIEWLRGNKVGDKRIRAGVPTGWRVGDKTGTGDYGTTNDVGVLWPPSRAPIVLAVYYTQTRADAKAKDDVIAAATRIASATLA 7ji2 A 1.95 BS01 III C 1 Y7 V9 E24 Y45 R62 E63 K66 N70 S73 F74 D77 L81 Y84 V97 Q114 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 Y7 V9 E24 Y45 R62 E63 K66 N70 S73 F74 D77 L81 Y84 V97 Q114 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELIQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRWEPPP 7ji2 D 1.95 BS01 III F 1 Y7 V9 E24 E63 K66 N70 S73 F74 V76 D77 L81 Y84 V97 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 Y7 V9 E24 E63 K66 N70 S73 F74 V76 D77 L81 Y84 V97 Y116 T143 K146 W147 E152 R155 L156 Y159 W167 Y171 GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELIQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRWEPPP 7jj8 B 2.03 BS01 ZN B 1 H63 H140 H204 E279 H37 H98 H162 E237 GKLNIVTTFYPVYEFTKQVAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKKKVKTIKATGDMLLLPGGEFDPHVWLSPVRAIKLVEHIRDSLSADYPDKKETFEKNAAAYIEKLQSLDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQVAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLNPLESLTEEDTKAGENYISVMEKNLKALKQTTDQ 7jj8 A 2.03 BS01 ZN A 1 H63 H140 H204 E279 H37 H98 H162 E237 GKLNIVTTFYPVYEFTKQVAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKKKVKTIKATGDMLLLPGGEFDPHVWLSPVRAIKLVEHIRDSLSADYPDKKETFEKNAAAYIEKLQSLDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQVAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLNPLESLTEEDTKAGENYISVMEKNLKALKQTTDQ 7jj8 C 2.03 BS01 ZN C 1 H63 H140 H204 E279 H37 H98 H162 E237 GKLNIVTTFYPVYEFTKQVAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKKKVKTIKATGDMLLLPGGEFDPHVWLSPVRAIKLVEHIRDSLSADYPDKKETFEKNAAAYIEKLQSLDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQVAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLNPLESLTEEDTKAGENYISVMEKNLKALKQTTDQ 7jj8 D 2.03 BS01 ZN D 1 H63 H140 H204 E279 H37 H98 H162 E237 GKLNIVTTFYPVYEFTKQVAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKKKVKTIKATGDMLLLPGGEFDPHVWLSPVRAIKLVEHIRDSLSADYPDKKETFEKNAAAYIEKLQSLDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQVAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLNPLESLTEEDTKAGENYISVMEKNLKALKQTTDQ 7jj9 A 1.58 BS01 ZN A 1 H63 H140 H204 E279 H37 H100 H164 E239 GKLNIVTTFYPVYEFTKQVAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKKKVKTIKATGDMLLLPGGHHEFDPHVWLSPVRAIKLVEHIRDSLSADYPDKKETFEKNAAAYIEKLQSLDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQVAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLNPLESLTEEDTKAGENYISVMEKNLKALKQTTDQEGPAIEPEKAEDTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTKINITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFSDHNIAPVKAEHFHIFFGGTSQETLFEEMDNWPTYYPDNLSGQEIAQEMLAH 7jj9 A 1.58 BS02 ZN A 2 H452 H461 H463 H412 H421 H423 GKLNIVTTFYPVYEFTKQVAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKKKVKTIKATGDMLLLPGGHHEFDPHVWLSPVRAIKLVEHIRDSLSADYPDKKETFEKNAAAYIEKLQSLDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQVAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLNPLESLTEEDTKAGENYISVMEKNLKALKQTTDQEGPAIEPEKAEDTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTKINITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFSDHNIAPVKAEHFHIFFGGTSQETLFEEMDNWPTYYPDNLSGQEIAQEMLAH 7jja A 1.01 BS01 EDT A 1 Y381 Y382 Y423 N427 S450 H452 H463 W481 Y61 Y62 Y103 N107 S130 H132 H143 W161 DTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTKINITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFSDHNIAPVKAEHFHIFFGGTSQETLFEEMDNWPTYYPDNLSGQEIAQEMLA 7jjb A 1.10 BS01 ZN A 1 H131 H140 H142 H132 H141 H143 DTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTKINITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFSDHNIAPVKAEHFHIFFGGTSQETLFEEMDNWPTYYPDNLSGQEIAQEMLA 7jjb A 1.10 BS02 ZN A 2 H131 H142 H132 H143 DTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTKINITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFSDHNIAPVKAEHFHIFFGGTSQETLFEEMDNWPTYYPDNLSGQEIAQEMLA 7jjb A 1.10 BS03 MG A 1 Q27 S28 F32 Q28 S29 F33 DTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTKINITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFSDHNIAPVKAEHFHIFFGGTSQETLFEEMDNWPTYYPDNLSGQEIAQEMLA 7jpz A 1.60 BS01 GHX A 1 H41 M49 Y54 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 L167 P168 H172 D187 R188 Q189 H41 M49 Y54 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 L167 P168 H172 D187 R188 Q189 3.4.22.69 33283984 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 7jq0 A 1.65 BS01 VHV A 1 H41 M49 F140 N142 G143 S144 C145 H163 H164 M165 E166 P168 D187 Q189 T190 A191 H41 M49 F140 N142 G143 S144 C145 H163 H164 M165 E166 P168 D187 Q189 T190 A191 3.4.22.69 33283984 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 7jq1 A 1.65 BS01 VHJ A 1 H41 M49 Y54 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 P168 D187 R188 Q189 T190 A191 H41 M49 Y54 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 P168 D187 R188 Q189 T190 A191 3.4.22.69 33283984 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 7jq2 A 1.40 BS01 VHM A 1 H41 M49 Y54 F140 N142 G143 S144 C145 H163 H164 M165 E166 P168 H172 D187 R188 Q189 T190 A191 H41 M49 Y54 F140 N142 G143 S144 C145 H163 H164 M165 E166 P168 H172 D187 R188 Q189 T190 A191 3.4.22.69 33283984 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 7jq3 A 2.10 BS01 VHP A 1 H41 F140 L141 N142 G143 C145 H163 H164 M165 E166 P168 D187 Q189 T190 A191 Q192 H41 F140 L141 N142 G143 C145 H163 H164 M165 E166 P168 D187 Q189 T190 A191 Q192 3.4.22.69 33283984 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 7jq4 A 1.65 BS01 XM2 A 1 H41 M49 Y54 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 L167 P168 D187 R188 Q189 T190 A191 Q192 H41 M49 Y54 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 L167 P168 D187 R188 Q189 T190 A191 Q192 3.4.22.69 33283984 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 7jq5 A 1.90 BS01 NOL A 1 H41 M49 Y54 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 P168 D187 R188 Q189 T190 A191 H41 M49 Y54 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 P168 D187 R188 Q189 T190 A191 3.4.22.69 33283984 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 7k6i A 1.41 BS01 ZN A 1 H94 H96 H119 H91 H93 H116 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6i A 1.41 BS02 VYV A 1 L57 E69 F70 D72 I91 Q92 F131 G132 L54 E66 F67 D69 I88 Q89 F127 G128 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6i A 1.41 BS03 VYV A 2 Q92 H94 H96 H119 V121 F131 L198 T199 T200 W209 Q89 H91 H93 H116 V118 F127 L194 T195 T196 W205 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6i A 1.41 BS04 VYV A 3 H4 W5 H10 N11 H15 W16 D19 H1 W2 H7 N8 H12 W13 D16 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6j A 1.76 BS01 ZN A 1 H94 H96 H119 H91 H93 H116 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6j A 1.76 BS02 VYY A 1 E69 F70 I91 Q92 H94 H96 H119 V121 F131 L198 T199 T200 W209 E66 F67 I88 Q89 H91 H93 H116 V118 F127 L194 T195 T196 W205 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6k A 1.31 BS01 ZN A 1 H94 H96 H119 H91 H93 H116 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6k A 1.31 BS02 VZ1 A 1 F70 I91 Q92 H94 H96 H119 F131 L198 T199 T200 W209 F67 I88 Q89 H91 H93 H116 F127 L194 T195 T196 W205 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6l A 1.66 BS01 ZN A 1 H94 H96 H119 H91 H93 H116 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6l A 1.66 BS02 VZD A 1 L57 E69 F70 D71 D72 I91 Q92 F131 V135 P202 L204 L54 E66 F67 D68 D69 I88 Q89 F127 V131 P198 L200 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6l A 1.66 BS03 VZD A 2 Q92 H94 H96 H119 V121 F131 L198 T199 T200 W209 Q89 H91 H93 H116 V118 F127 L194 T195 T196 W205 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6l A 1.66 BS04 VZD A 3 H4 W5 H10 N11 H15 W16 D19 H1 W2 H7 N8 H12 W13 D16 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6t A 1.76 BS01 ZN A 1 H94 H96 H119 H91 H93 H116 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6t A 1.76 BS02 VYV A 1 Q92 H94 H96 H119 V121 V131 G132 V135 V143 L198 T199 T200 W209 Q89 H91 H93 H116 V118 V127 G128 V131 V139 L194 T195 T196 W205 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6u A 1.61 BS01 ZN A 1 H94 H96 H119 H91 H93 H116 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6u A 1.61 BS02 VYY A 1 W5 Y7 H64 S65 Q67 Q92 H94 H96 H119 V121 V143 L198 T199 T200 W209 N244 W2 Y4 H61 S62 Q64 Q89 H91 H93 H116 V118 V139 L194 T195 T196 W205 N240 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6x A 1.76 BS01 ZN A 1 H94 H96 H119 H91 H93 H116 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6x A 1.76 BS02 VZ1 A 1 Q67 T69 F70 L91 Q92 H94 H96 H119 V121 L141 V143 L198 T199 T200 W209 Q64 T66 F67 L88 Q89 H91 H93 H116 V118 L137 V139 L194 T195 T196 W205 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6z A 1.66 BS01 ZN A 1 H94 H96 H119 H91 H93 H116 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7k6z A 1.66 BS02 VZD A 1 Q92 H94 H96 H119 V121 V131 G132 V135 L198 T199 T200 W209 Q89 H91 H93 H116 V118 V127 G128 V131 L194 T195 T196 W205 4.2.1.1 33303238 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7kl0 A 2.40 BS01 III C 1 K56 E96 F98 E99 I101 N135 K137 E139 F173 A174 G175 T176 P177 G178 I205 Y210 P211 P212 W214 Q218 P233 E236 K50 E90 F92 E93 I95 N129 K131 E133 F167 A168 G169 T170 P171 G172 I199 Y204 P205 P206 W208 Q212 P227 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl0 A 2.40 BS02 UZD A 1 L19 A40 K42 F89 D90 L91 V92 E96 L142 D156 L13 A34 K36 F83 D84 L85 V86 E90 L136 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl0 B 2.40 BS01 III D 1 K56 E96 F98 E99 N135 K137 E139 L159 F173 A174 G175 T176 P177 G178 Y179 I205 G209 Y210 P211 W214 P233 S234 E236 K50 E90 F92 E93 N129 K131 E133 L153 F167 A168 G169 T170 P171 G172 Y173 I199 G203 Y204 P205 W208 P227 S228 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl0 B 2.40 BS02 UZD B 1 L19 A40 K42 V73 F89 D90 L91 V92 L142 D156 L13 A34 K36 V67 F83 D84 L85 V86 L136 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl1 A 2.40 BS01 III C 1 E96 F98 E99 I101 V102 N135 K137 E139 L159 F173 A174 G175 T176 P177 G178 Y179 I205 Y210 P211 P212 W214 Q218 Y222 P233 E236 E90 F92 E93 I95 V96 N129 K131 E133 L153 F167 A168 G169 T170 P171 G172 Y173 I199 Y204 P205 P206 W208 Q212 Y216 P227 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl1 A 2.40 BS02 ATP A 1 L19 A40 D90 L91 V92 E96 N140 L142 D156 L13 A34 D84 L85 V86 E90 N134 L136 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl1 A 2.40 BS03 MG A 1 E139 N140 D156 E133 N134 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl1 B 2.40 BS01 III D 1 R52 K56 E96 F98 E99 N135 K137 E139 L159 F171 F173 A174 G175 T176 G178 Y179 I205 Y210 P211 W214 E216 Q218 S234 E236 R46 K50 E90 F92 E93 N129 K131 E133 L153 F165 F167 A168 G169 T170 G172 Y173 I199 Y204 P205 W208 E210 Q212 S228 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl1 B 2.40 BS02 ATP B 1 L19 A40 D90 V92 E96 N135 K137 N140 L142 D156 L13 A34 D84 V86 E90 N129 K131 N134 L136 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl1 B 2.40 BS03 MG B 1 N140 D156 N134 D150 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl2 A 2.56 BS01 III B 1 R52 E96 F98 V102 N135 K137 E139 L159 F173 A174 G175 T176 G178 Y179 G209 Y210 P211 P212 W214 Q218 H219 S234 P235 E236 R46 E90 F92 V96 N129 K131 E133 L153 F167 A168 G169 T170 G172 Y173 G203 Y204 P205 P206 W208 Q212 H213 S228 P229 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7kl4 A 2.25 BS01 III B 1 R52 E96 F98 N135 K137 E139 L159 F173 G175 T176 P177 G178 Y210 P211 W214 Q218 E236 R46 E90 F92 N129 K131 E133 L153 F167 G169 T170 P171 G172 Y204 P205 W208 Q212 E230 2.7.11.17 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 7knp A 2.25 BS01 WT7 A 1 I335 T336 V411 G412 E413 P414 D436 T437 Y438 W439 M440 T441 D527 I539 R542 I324 T325 V400 G401 E402 P403 D425 T426 Y427 W428 M429 T430 D516 I528 R531 6.2.1.1 VHHVHPLPDSVPESEDLFAPPPRMQGKEGRPKPHIGPNYESYVKEWAKTVGPNSDEWWAAKARETLDWYDDFKTVRAGGFEHGDVQWFPEGTLNAAYNCLDRHYYKNPKKTAIIYEADEPSESREVSYEELMQETCRVANVLKSYGVKKGDAVSIYLPMTWQAAAAFLACARIGAIHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKTIATKQIVDAALQQCPLVENVLVLRRTGNKVPMTEGRDKWWDEECAKMPAYCPCERMASEDPLFILYTSTGKPKGVVHSTAGYLLGTALTLKYVFDAHPDDRFACMADIGWITGHSYIIYGPLANGITTAVFESTPVYPTPSRYWDFVDKWKATQLYTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPINPEAWHWYNDFAGKNQCAIVDTYWMTETGSISIAPLPGAISTKPGSATFPFFGMDVDIIDPQTGQVLEGNDVEGVLVARRPWPSIARTVYRDHKRYLETYMKPYPGYFFFGDGAARDYDGYMWIKGRVDDVINVSGHRLSTAEVESALILHKGVAETAVVGCADDLTGQAVYAFVTMKPEFDLKATKEADLSKELAIQVRKVIGPFAAPKKIYLVSDLPKTRSGKIMRRVLRKIVAGEGQIVEEVKQKV 7knp B 2.25 BS01 WT7 B 1 I335 T336 V411 G412 E413 P414 D436 T437 Y438 W439 M440 T441 D527 I539 R542 I322 T323 V398 G399 E400 P401 D423 T424 Y425 W426 M427 T428 D514 I526 R529 6.2.1.1 VHHVHPLPDSVPESEDLFAPPPRMQGKEGRPKPHIGPNYESYVKEWAKTVGPNSDEWWAAKARETLDWYDDFKTVRAGGFEHGDVQWFPEGTLNAAYNCLDRHYYKNPKKTAIIYEADEPSESREVSYEELMQETCRVANVLKSYGVKKGDAVSIYLPMTWQAAAAFLACARIGAIHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKTIATKQIVDAALQQCPLVENVLVLRRTGNKVPMTEGRDKWWDEECAKMPAYCPCERMASEDPLFILYTSKPKGVVHSTAGYLLGTALTLKYVFDAHPDDRFACMADIGWITGHSYIIYGPLANGITTAVFESTPVYPTPSRYWDFVDKWKATQLYTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPINPEAWHWYNDFAGKNQCAIVDTYWMTETGSISIAPLPGAISTKPGSATFPFFGMDVDIIDPQTGQVLEGNDVEGVLVARRPWPSIARTVYRDHKRYLETYMKPYPGYFFFGDGAARDYDGYMWIKGRVDDVINVSGHRLSTAEVESALILHKGVAETAVVGCADDLTGQAVYAFVTMKPEFDLKEADLSKELAIQVRKVIGPFAAPKKIYLVSDLPKTRSGKIMRRVLRKIVAGEGDQSSIADPQIVEEVKQKVTG 7knp C 2.25 BS01 WT7 C 1 T336 V411 G412 P414 T437 Y438 W439 M440 T441 D527 I539 T307 V382 G383 P385 T408 Y409 W410 M411 T412 D498 I510 6.2.1.1 LFAPPPRMQGKEGRPKPHIGPNYESYVKEWAKTVGPNSDEWWAAKARETLDWYDDFKTVRAGGFEHGDVQWFPEGTLNAAYNCLDRHYYKNPKKTAIIYEADEPSESREVSYEELMQETCRVANVLKSYGVKKGDAVSIYLPMTWQAAAAFLACARIGAIHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKTIATKQIVDAALQQCPLVENVLVLRRTGNKVPMTEGRDKWWDEECAKMPAYCPCERMASEDPLFILYTSKPKGVVHSTAGYLLGTALTLKYVFDAHPDDRFACMADIGWITGHSYIIYGPLANGITTAVFESTPVYPTPSRYWDFVDKWKATQLYTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPINPEAWHWYNDFAGKNQCAIVDTYWMTETGSISIAPLPGAISTKPGSATFPFFGMDVDIIDPQTGQVLEGNDVEGVLVARRPWPSIARTVYRDHKRYLETYMKPYPGYFFFGDGAARDYDGYMWIK 7kv8 A 2.50 BS01 6OU A 1 T404 T405 G408 A409 R411 F422 G423 T404 T405 G408 A409 R411 F422 G423 MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKHPATLRKYCIEAKLTNTTTASRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEENAVGNDTGKHGKEIKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSTSLSVSLVLVGVVTLYLGVMVQA 7kv8 A 2.50 BS02 1Q0 A 1 M412 A413 I414 G416 W420 H437 G441 Y444 Y489 L490 M412 A413 I414 G416 W420 H437 G441 Y444 Y486 L487 MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKHPATLRKYCIEAKLTNTTTASRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEENAVGNDTGKHGKEIKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSTSLSVSLVLVGVVTLYLGVMVQA 7kv8 B 2.50 BS01 6OU B 1 T404 T405 G408 A409 R411 M412 F422 T404 T405 G408 A409 R411 M412 F422 MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKHPATLRKYCIEAKLTNTTTASRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEENAVGNDTGKHGKEIKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSTSLSVSLVLVGVVTLYLGVMVQA 7kv8 B 2.50 BS02 1Q0 B 1 A409 M412 A413 I414 L415 G416 W420 G433 H437 Y444 Y489 L490 A409 M412 A413 I414 L415 G416 W420 G433 H437 Y444 Y486 L487 MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKHPATLRKYCIEAKLTNTTTASRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEENAVGNDTGKHGKEIKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSTSLSVSLVLVGVVTLYLGVMVQA 7kv8 C 2.50 BS01 6OU C 1 T404 T405 G408 A409 R411 M412 T404 T405 G408 A409 R411 M412 MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKHPATLRKYCIEAKLTNTTTASRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEENAVGNDTGKHGKEIKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSTSLSVSLVLVGVVTLYLGVMVQA 7kv8 C 2.50 BS02 1Q0 C 1 M412 A413 I414 G416 G433 L436 H437 G441 Y444 V485 Y489 L490 M412 A413 I414 G416 G433 L436 H437 G441 Y444 V482 Y486 L487 MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKHPATLRKYCIEAKLTNTTTASRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEENAVGNDTGKHGKEIKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSTSLSVSLVLVGVVTLYLGVMVQA 7ky3 C 2.70 BS01 SPM C 1 W30 I85 I86 I87 S92 G93 G95 A97 K127 A128 H130 I131 Y132 W28 I83 I84 I85 S90 G91 G93 A95 K125 A126 H128 I129 Y130 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7ky3 C 2.70 BS02 SPM C 2 H48 L49 D51 E52 E54 R55 R56 H46 L47 D49 E50 E52 R53 R54 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7ky3 B 2.70 BS01 SPM A 1 H48 L49 D51 E52 E54 R55 R56 H46 L47 D49 E50 E52 R53 R54 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYI 7ky3 A 2.70 BS01 SPM A 2 H48 L49 D51 E52 E54 R55 H46 L47 D49 E50 E52 R53 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7ky3 A 2.70 BS02 SPM A 1 N21 E32 E33 Y35 E36 E40 L44 N19 E30 E31 Y33 E34 E38 L42 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7ky4 C 3.00 BS01 SPM C 1 N21 E32 E33 Y35 E36 E40 L44 N19 E30 E31 Y33 E34 E38 L42 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7ky4 C 3.00 BS02 SPM A 1 H48 L49 D51 E52 E54 R55 H46 L47 D49 E50 E52 R53 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7ky4 A 3.00 BS01 SPM A 1 N21 M27 E32 E33 Y35 E36 E40 L44 N19 M25 E30 E31 Y33 E34 E38 L42 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7ky4 B 3.00 BS01 SPM B 1 N21 M27 E32 E33 Y35 E36 E40 L41 N19 M25 E30 E31 Y33 E34 E38 L39 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7ky4 B 3.00 BS02 SPM D 1 H48 L49 D51 E52 E54 R55 R56 H46 L47 D49 E50 E52 R53 R54 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7ky4 D 3.00 BS01 SPM D 1 N21 M27 E32 E33 Y35 E36 E40 N19 M25 E30 E31 Y33 E34 E38 AMKLRALEYSDLLFVHELNNEYSIMSYWFEEPYESLTELQHLFDKHLLDESERRFIVEDENQVVGIVELVEINYIHRNCEIQIIIKPEFSGKGYAKFAFEKAIIYAFNILNMHKIYLYVDADNKKAIHIYESEGFKTEGLLKEQFYTKGKYKDAYFMSLLKSEYIL 7kz7 A 1.80 BS01 ZN A 1 H227 H231 E266 H227 H231 E266 3.4.24.69 MKLEINKFNYNDPIDGINVITMRPPRHSDKINKGKGPFKAFQVIKNIWIVPERYNFTNNTNDLNIPSEPIMEADAIYNPNYLNTPSEKDEFLQGVIKVLERIKSKPEGEKLLELISSSIPLPLVSNGALTLSDNETIAYQENDNIVSTLQANLVIYGPGPDIANNEIYGLYSTPISNGEGTLSEVSFSPFYLKPFDESYGNYRSLVNIVNKFVKREFAPDPASTLMHELVHVTHNLYGISNRNFYYNFDTGKIETSRQQNSLIFEELLTFGGIDSKAISSLIIKKIIETAKNNYTTLISERLNTVTVENDLLKNIKNKIPVQGRLGNFKLDTAEFEKKLNTILFVLNESNLAQRFSILVRKHYIKERPIDPIYVNILDDNSYSTLEGFNISSQGSNDFQGQLLESSYFEKIESNALRAFIKICP 7l0a A 1.60 BS01 MG A 1 L47 S120 M121 N151 L56 S129 M130 N160 3.1.2.12 GLVPRGSHMAYISLNYHSPTIGMHQNLTVILPEDQSFFNSDTTVKPLKTLMLLHGLSSDETTYMRYTSIERYANEHKLAVIMPNVDHSAYANMAYGHSYYDYILEVYDYVHQIFPLSKKRDDNFIAGHSMGGYGTIKFALTQGDKFAKAVPLSAVFEAQNLMDLEWNDFSKEAEHDPYYLLDKAVAEDKQIPKLLIMCGKQDFLYQDNLDFIDYLSRINVPYQFEDGPGDHDYAYWDQAIKRAITWMVN 7l0a B 1.60 BS01 MG B 1 G46 L47 S120 M121 G49 L50 S123 M124 3.1.2.12 SHMAYISLNYHSPTIGMHQNLTVILPEDQSFFNSDTTVKPLKTLMLLHGLSSDETTYMRYTSIERYANEHKLAVIMPNVDHSAYANMAYGHSYYDYILEVYDYVHQIFPLSKKRDDNFIAGHSMGGYGTIKFALTQGDKFAKAVPLSAVFEAQNLMDLEWNDFSKEAIIGNLSSVKGTEHDPYYLLDKAVAEDKQIPKLLIMCGKQDFLYQDNLDFIDYLSRINVPYQFEDGPGDHDYAYWDQAIKRAITWMVN 7l0a B 1.60 BS02 MG B 2 G46 L47 S48 S49 H119 G49 L50 S51 S52 H122 3.1.2.12 SHMAYISLNYHSPTIGMHQNLTVILPEDQSFFNSDTTVKPLKTLMLLHGLSSDETTYMRYTSIERYANEHKLAVIMPNVDHSAYANMAYGHSYYDYILEVYDYVHQIFPLSKKRDDNFIAGHSMGGYGTIKFALTQGDKFAKAVPLSAVFEAQNLMDLEWNDFSKEAIIGNLSSVKGTEHDPYYLLDKAVAEDKQIPKLLIMCGKQDFLYQDNLDFIDYLSRINVPYQFEDGPGDHDYAYWDQAIKRAITWMVN