5bk4 2 3.90 BS01 NUC S 1 P372 K587 P172 K375 3.6.4.12 PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSSPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIY 5bk4 2 3.90 BS02 ADP 2 1 G546 T547 K549 S550 E608 L695 G334 T335 K337 S338 E396 L483 3.6.4.12 PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSSPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIY 5bk4 2 3.90 BS03 ADP 5 1 R676 V807 R464 V546 3.6.4.12 PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSSPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIY 5bk4 3 3.90 BS01 NUC O 1 S309 R450 T479 D480 S255 R396 T425 D426 3.6.4.12 TFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALL 5bk4 3 3.90 BS02 ADP 3 1 P411 S412 T413 A414 K415 S416 Q417 P357 S358 T359 A360 K361 S362 Q363 3.6.4.12 TFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALL 5bk4 3 3.90 BS03 ADP 7 1 E491 R542 E703 E437 R488 E569 3.6.4.12 TFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALL 5bk4 4 3.90 BS01 NUC S 1 R449 Q450 R265 Q266 3.6.4.12 LRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDERDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKVSDKRLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYAT 5bk4 4 3.90 BS02 NUC O 1 N447 R449 K612 N263 R265 K427 3.6.4.12 LRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDERDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKVSDKRLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYAT 5bk4 5 3.90 BS01 NUC O 1 K304 P457 R460 K284 P425 R428 3.6.4.12 SFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAAS 5bk4 5 3.90 BS02 ADP 3 1 I650 R651 I618 R619 3.6.4.12 SFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAAS 5bk4 5 3.90 BS03 ADP 5 1 S377 I378 F379 G419 A421 K422 S423 Q424 I568 S345 I346 F347 G387 A389 K390 S391 Q392 I536 3.6.4.12 SFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAAS 5bk4 6 3.90 BS01 NUC S 1 R614 A666 R389 A441 3.6.4.12 VDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSSTLDTRGISKTSLGVRDLTYKISFLACHVISIGSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV 5bk4 7 3.90 BS01 NUC O 1 D530 E531 D490 E491 3.6.4.12 MSAALPSIQLPVDYNNLFNEITDFLVTFKQDKGPKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMNDALREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQ 5bk4 7 3.90 BS02 ADP 7 1 I422 Y423 P462 G463 A465 K466 S467 I382 Y383 P422 G423 A425 K426 S427 3.6.4.12 MSAALPSIQLPVDYNNLFNEITDFLVTFKQDKGPKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMNDALREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQ 5bk4 A 3.90 BS01 ADP A 1 G546 T547 A548 K549 S550 E608 G334 T335 A336 K337 S338 E396 3.6.4.12 PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSSPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIY 5bk4 B 3.90 BS01 NUC S 1 Q308 N310 R450 D480 V481 Q254 N256 R396 D426 V427 3.6.4.12 TFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALL 5bk4 B 3.90 BS02 ADP B 1 S412 T413 A414 K415 S416 Q417 S358 T359 A360 K361 S362 Q363 3.6.4.12 TFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALL 5bk4 B 3.90 BS03 ADP F 1 E491 R542 R700 E703 E437 R488 R566 E569 3.6.4.12 TFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALL 5bk4 C 3.90 BS01 NUC S 1 N447 S448 R449 K612 N263 S264 R265 K427 3.6.4.12 LRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDERDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKVSDKRLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYAT 5grm A 1.55 BS01 1SY B 1 S162 Y163 Y167 R238 Y240 T263 P264 S15 Y16 Y20 R91 Y93 T116 P117 YFQGSHMVAHGLAWSYYIGYLKLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDDLSVADPNIRFRDMLPQQNTDRAGVKNRAYSNSVYELLENGQPAGACILEYATPLQTLFAMSQDGKAGFSREDRLEQAKLFCRTLEEILADVPESRNHCRLIVYQESEEGNSFSLSQEVLRHIRQ 5grm B 1.55 BS01 1SY B 1 S162 Y163 Y167 R238 A239 Y240 T263 P264 S11 Y12 Y16 R87 A88 Y89 T112 P113 SHMVAHGLAWSYYIGYLKLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDDLSVADPNIRFRDMLPQQNTDRAGVKNRAYSNSVYELLENGQPAGACILEYATPLQTLFAMSQDGKAGFSREDRLEQAKLFCRTLEEILADVPESRNHCRLIVYQESEEGNSFSLSQEVLRHIRQEEKEEV 5gwr A 2.20 BS01 NAD A 1 G11 N13 S14 G15 I16 D35 I36 I56 D57 L58 A84 A85 G86 I87 V107 I135 A136 S137 Y150 K154 P180 G181 I183 T185 L187 T188 G8 N10 S11 G12 I13 D32 I33 I53 D54 L55 A81 A82 G83 I84 V104 I132 A133 S134 Y147 K151 P177 G178 I180 T182 L184 T185 NKIIMISGANSGIGHACIKYFLEKSFHVIALDINNNNLIDYMKTDMPLKVVQIDLSNSEAIHNLFTQLDLEKLSPDILINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVAKRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGLTKQMAMEFGKQNIRVNSISPGVIRTELTEEYFSNKALMSMIKSNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDGGWTAGK 5gwr B 2.20 BS01 NAD B 1 G11 S14 G15 I16 D35 I36 I56 D57 L58 A84 A85 G86 I87 V107 I135 Y150 K154 G8 S11 G12 I13 D32 I33 I46 D47 L48 A74 A75 G76 I77 V97 I125 Y140 K144 NKIIMISGANSGIGHACIKYFLEKSFHVIALDINNNNLMPLKVVQIDLSNSEAIHNLFTQLDLEKLSPDILINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVAKRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGLTKQMAMEFGKQNIRVNSISPGVIRTEALMSMIKSNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDGGWTAGK 5gwr C 2.20 BS01 NAD C 1 G11 S14 G15 I16 D35 I36 N37 I56 D57 L58 A84 A85 G86 I87 V107 I135 Y150 K154 T185 G8 S11 G12 I13 D32 I33 N34 I46 D47 L48 A74 A75 G76 I77 V97 I125 Y140 K144 T175 NKIIMISGANSGIGHACIKYFLEKSFHVIALDINNNNLMPLKVVQIDLSNSEAIHNLFTQLDLEKLSPDILINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVAKRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGLTKQMAMEFGKQNIRVNSISPGVIRTEALMSMIKSNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDGGWTAGK 5gwr D 2.20 BS01 NAD D 1 G11 S14 D35 I36 I56 D57 L58 A85 G86 I87 V107 G8 S11 D32 I33 I46 D47 L48 A75 G76 I77 V97 NKIIMISGANSGIGHACIKYFLEKSFHVIALDINNNNLMPLKVVQIDLSNSEAIHNLFTQLDLEKLSPDILINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVAKRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGLTKQMAMEFGKQNIRVNSISPGVIRTEALMSMIKSNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDGGWTAGK 5gws B 2.35 BS01 NAD B 1 G11 S14 G15 I16 D35 I36 I56 D57 L58 A84 A85 G86 I87 V107 I135 A136 S137 Y150 K154 P180 G181 I183 G6 S9 G10 I11 D30 I31 I44 D45 L46 A72 A73 G74 I75 V95 I123 A124 S125 Y138 K142 P168 G169 I171 IIMISGANSGIGHACIKYFLEKSFHVIALDINNNNLMPLKVVQIDLSNSEAIHNLFTQLDLEKLSPDILINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVAKRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGLTKQMAMEFGKQNIRVNSISPGVISNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDGGWTAG 5h43 A 2.30 BS01 III B 1 G281 R315 V321 T322 G323 D325 T328 K353 E354 W357 S360 N361 A364 G365 R366 E396 W399 N403 S406 G212 R246 V252 T253 G254 D256 T259 K284 E285 W288 S291 N292 A295 G296 R297 E327 W330 N334 S337 28991411 NQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFS 5h43 A 2.30 BS02 III C 1 S105 F138 W142 N146 A148 S149 G150 T151 T155 Q181 W184 N188 G191 D192 W231 N235 R238 N239 P265 E266 A269 D270 W273 P308 T311 S36 F69 W73 N77 A79 S80 G81 T82 T86 Q112 W115 N119 G122 D123 W162 N166 R169 N170 P196 E197 A200 D201 W204 P239 T242 28991411 NQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFS 5iuv A 1.93 BS01 NAD A 1 I164 V165 P166 W167 N168 M173 K191 S193 E194 G224 G228 K229 F242 T243 G244 S245 I248 L252 Y255 E267 A268 G269 C302 E401 F403 F467 I162 V163 P164 W165 N166 M171 K189 S191 E192 G222 G226 K227 F240 T241 G242 S243 I246 L250 Y253 E265 A266 G267 C300 E399 F401 F465 TLTRADWEQRAQNLKIEGRAFIQGEYTAAASGETFDCISPVDGRLLAKVASCDAADAQRAVESARSAFDSGAWSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGVDIPGGARALSWSGEAIDKLYDEVAATPHDQLGLVTREPVGVVAAIVPWNFPLMMACWKLGPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALALHMDVDTVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIAFNQGEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTVLSYIAAGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTAEEAIQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELKSTWIKL 5iuw A 2.09 BS02 IAC A 1 V119 F169 M172 M173 C302 D459 F467 V117 F167 M170 M171 C300 D457 F465 TLTRADWEQRAQNLKIEGRAFIQGEYTAAASGETFDCISPVDGRLLAKVASCDAADAQRAVESARSAFDSGAWSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGVDIPGGARALSWSGEAIDKLYDEVAATPHDQLGLVTREPVGVVAAIVPWNFPLMMACWKLGPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALALHMDVDTVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIAFNQGEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTVLSYIAAGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTAEEAIQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELKSTWIKL 5iuw B 2.09 BS02 IAC B 1 N168 M173 W176 V301 C302 T303 D459 F467 N166 M171 W174 V299 C300 T301 D457 F465 TLTRADWEQRAQNLKIEGRAFIQGEYTAAASGETFDCISPVDGRLLAKVASCDAADAQRAVESARSAFDSGAWSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGVDIPGGARALSWSGEAIDKLYDEVAATPHDQLGLVTREPVGVVAAIVPWNFPLMMACWKLGPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALALHMDVDTVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIAFNQGEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTVLSYIAAGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTAEEAIQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELKSTWIKL 5j7j A BS01 III B 1 Q8 E11 A15 F19 L32 V35 M36 L48 M51 E54 V55 I63 F68 M71 M72 K75 T79 E87 A88 V91 F92 L112 G113 E114 K115 L116 E123 M124 E127 A128 V136 F141 M144 M145 A147 Q5 E8 A12 F16 L29 V32 M33 L45 M48 E51 V52 I60 F65 M68 M69 K72 T76 E84 A85 V88 F89 L109 G110 E111 K112 L113 E120 M121 E124 A125 V133 F138 M141 M142 A144 LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 5kwh A 2.12 BS01 6XT A 1 G48 V53 V66 K68 I95 F113 E114 V116 N118 M163 I174 D175 G47 V52 V65 K67 I94 F112 E113 V115 N117 M162 I173 D174 2.7.11.1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQA 5kwh B 2.12 BS01 6XT B 1 L45 G48 V53 V66 K68 I95 E114 H115 V116 N118 H160 M163 I174 D175 L44 G47 V52 V65 K67 I94 E113 H114 V115 N117 H159 M162 I173 D174 2.7.11.1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQA 5lew A 2.80 BS01 ZN A 1 E73 H107 C158 E67 H101 C152 2.7.7.7 29021523 GSSFVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGMTDHGNMFGASEFYNSATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQKADDVSGSGSYTHLTMMAENATGLRNLFKLSSHASFEGQLSKWSRMDAELIAEHAEGIIITTGCPSGEVQTRLRLGQDREALEAAAKWREIVGPDNYFLELMDHGLTIERRVRDGLLEIGRALNIPPLATNDCHYVTRDAAHNHEALLCVQTGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDDEVPGACDSTLLIAERVQSYADVWTPRDRMPVFPVPDGHDQASWLRHEVDAGLRRRFPAGPPDGYRERAAYEIDVICSKGFPSYFLIVADLISYARSAGIRVGPGRGSAAGSLVAYALGITDIDPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPAIMAKDIPLSGITEAAEVRGLIETDPDVRTIYQTARGLEGLIRNAGVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLGLRNLTIIGDAIDNVRANRGIDLDLESVPLDDKATYELLGRGDTLGVFQLDGGPMRDLLRRMQPTGFEDVVAVIALYRPGPMGMNAHNDYADRKNNRQAIKPIHPELEEPLREILAETYGLIVYQEQIMRIAQKVASYSLARADILRKAMGKKKREVLEKEFEGFSDGMQANGFSPAAIKALWDTILPFADYAFNKSHAAGYGMVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLPPDVNESGLNFASVGQDIRYGLGAVRNVGANVVGSLLQTRNDKGKFTDFSDYLNKIDISACNKKVTESLIKAGAFDSLGHARKGLFLVHSDAVD 5lew A 2.80 BS02 ZN A 2 H14 H16 E73 D226 H8 H10 E67 D220 2.7.7.7 29021523 GSSFVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGMTDHGNMFGASEFYNSATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQKADDVSGSGSYTHLTMMAENATGLRNLFKLSSHASFEGQLSKWSRMDAELIAEHAEGIIITTGCPSGEVQTRLRLGQDREALEAAAKWREIVGPDNYFLELMDHGLTIERRVRDGLLEIGRALNIPPLATNDCHYVTRDAAHNHEALLCVQTGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDDEVPGACDSTLLIAERVQSYADVWTPRDRMPVFPVPDGHDQASWLRHEVDAGLRRRFPAGPPDGYRERAAYEIDVICSKGFPSYFLIVADLISYARSAGIRVGPGRGSAAGSLVAYALGITDIDPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPAIMAKDIPLSGITEAAEVRGLIETDPDVRTIYQTARGLEGLIRNAGVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLGLRNLTIIGDAIDNVRANRGIDLDLESVPLDDKATYELLGRGDTLGVFQLDGGPMRDLLRRMQPTGFEDVVAVIALYRPGPMGMNAHNDYADRKNNRQAIKPIHPELEEPLREILAETYGLIVYQEQIMRIAQKVASYSLARADILRKAMGKKKREVLEKEFEGFSDGMQANGFSPAAIKALWDTILPFADYAFNKSHAAGYGMVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLPPDVNESGLNFASVGQDIRYGLGAVRNVGANVVGSLLQTRNDKGKFTDFSDYLNKIDISACNKKVTESLIKAGAFDSLGHARKGLFLVHSDAVD 5lew A 2.80 BS03 ZN A 3 D23 H48 H228 D17 H42 H222 2.7.7.7 29021523 GSSFVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGMTDHGNMFGASEFYNSATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQKADDVSGSGSYTHLTMMAENATGLRNLFKLSSHASFEGQLSKWSRMDAELIAEHAEGIIITTGCPSGEVQTRLRLGQDREALEAAAKWREIVGPDNYFLELMDHGLTIERRVRDGLLEIGRALNIPPLATNDCHYVTRDAAHNHEALLCVQTGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDDEVPGACDSTLLIAERVQSYADVWTPRDRMPVFPVPDGHDQASWLRHEVDAGLRRRFPAGPPDGYRERAAYEIDVICSKGFPSYFLIVADLISYARSAGIRVGPGRGSAAGSLVAYALGITDIDPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPAIMAKDIPLSGITEAAEVRGLIETDPDVRTIYQTARGLEGLIRNAGVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLGLRNLTIIGDAIDNVRANRGIDLDLESVPLDDKATYELLGRGDTLGVFQLDGGPMRDLLRRMQPTGFEDVVAVIALYRPGPMGMNAHNDYADRKNNRQAIKPIHPELEEPLREILAETYGLIVYQEQIMRIAQKVASYSLARADILRKAMGKKKREVLEKEFEGFSDGMQANGFSPAAIKALWDTILPFADYAFNKSHAAGYGMVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLPPDVNESGLNFASVGQDIRYGLGAVRNVGANVVGSLLQTRNDKGKFTDFSDYLNKIDISACNKKVTESLIKAGAFDSLGHARKGLFLVHSDAVD 5lvx A 2.20 BS01 79B A 1 E235 S237 Q284 Y313 L314 F316 E340 C342 S345 K346 W348 E235 S237 Q284 Y313 L314 F316 E340 C342 S345 K346 W348 3.2.1.45 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 5lvx A 2.20 BS02 7E4 B 1 L241 S242 G243 F347 L241 S242 G243 F347 3.2.1.45 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 5lvx D 2.20 BS01 7E4 C 1 S242 P245 F347 S242 P245 F347 3.2.1.45 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 5lw3 A 1.19 BS01 CA A 1 S91 P92 E95 T97 G124 D133 S90 P91 E94 T96 G123 D132 5.1.3.- DYNVKDFGALGDGVSDDRVAIQAAIDAAHAAGGGTVYLPPGEYRVSAAGEPSDGCLTLRDNVYLAGAGMGQTVIKLVDGSAQKITGIVRSPFGEETSNFGMRDLTLDGNRANTVDKVDGWFNGYAPGQPGADRNVTIERVEVREMSGYGFDPHEQTINLVLRDSVAHHNGLDGFVADYQIGGTFENNVAYANDRHGFNIVTSTNDFVMRNNVAYGNGGNGLVVQRGSENLAHPENILIDGGSYYDNGLEGVLVKMSNNVTVQNADIHGNGSSGVRVYGAQGVQILGNQIHDNAKTAVAPEVLLQSYDDTLGVSGNYYTTLNTRVEGNTITGSANSTYGVQERNDGTDFSSLVGNTINGVQEAAHLYGPNSTVSGTVSAPPQ 5lx3 A 2.10 BS01 7A1 A 1 Y188 H191 F193 R196 D219 S241 V242 A244 S275 T304 I309 R311 R349 I351 I378 A379 Y168 H171 F173 R176 D199 S221 V222 A224 S255 T284 I289 R291 R329 I331 I358 A359 2.4.2.12 FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLN 5lx5 A 1.88 BS01 7A0 A 1 Y188 H191 F193 R196 D219 S241 V242 A244 S275 T304 I309 R311 R349 I351 I378 A379 G383 G384 Y168 H171 F173 R176 D199 S221 V222 A224 S255 T284 I289 R291 R329 I331 I358 A359 G363 G364 2.4.2.12 FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLN 5lxu A 2.14 BS01 NUC U 1 V170 P171 K172 R185 Q193 R196 V27 P28 K29 R42 Q50 R53 RPRLVWTPQLHKRFVDVVAHLGIKNAVPKTIMQLMNVEGLTRENVASHLQKYRLYLK 5lxu A 2.14 BS02 NUC B 1 R146 L147 W149 N187 S190 Q193 K194 R3 L4 W6 N44 S47 Q50 K51 RPRLVWTPQLHKRFVDVVAHLGIKNAVPKTIMQLMNVEGLTRENVASHLQKYRLYLK 5ly0 A 1.88 BS01 ZN A 1 C28 C31 C38 C42 C3 C6 C13 C17 APCAACKFLRRKCLPGCVFAPYFPPEEPQKFANVHKVFGASNVTKLLNELPPHQREDAVSSLAYEAEARVKDPVYGCVGAISVLQRQVHRLQKELDAAHTELLRYACG 5lyn A 2.00 BS01 III D 1 K106 N110 M113 Y125 I137 N141 A144 S147 R171 R175 F178 Y181 Y193 S214 K14 N18 M21 Y33 I45 N49 A52 S55 R79 R83 F86 Y89 Y101 S122 GSMAETKAKAEDLKMQGNKAMANKDYELAINKYTEAIKVLPTNAIYYANRAAAHSSLKEYDQAVKDAESAISIDPSYFRGYSRLGFAKYAQGKPEEALEAYKKVLDIEGDNATEAMKRDYESAKKKVEQSLNL 5lyn A 2.00 BS02 ZN A 1 K124 E127 K32 E35 GSMAETKAKAEDLKMQGNKAMANKDYELAINKYTEAIKVLPTNAIYYANRAAAHSSLKEYDQAVKDAESAISIDPSYFRGYSRLGFAKYAQGKPEEALEAYKKVLDIEGDNATEAMKRDYESAKKKVEQSLNL 5lyn B 2.00 BS01 III C 1 K106 N110 M113 Y125 N141 Y169 R171 S174 R175 F178 D211 K14 N18 M21 Y33 N49 Y77 R79 S82 R83 F86 D119 GSMAETKAKAEDLKMQGNKAMANKDYELAINKYTEAIKVLPTNAIYYANRAAAHSSLKEYDQAVKDAESAISIDPSYFRGYSRLGFAKYAQGKPEEALEAYKKVLDIEGDNATEAMKRDYESAKKKVEQSLNL 5m01 A 1.95 BS01 III P 1 Y7 E9 Y45 Y59 E63 K66 Q70 W73 V76 S77 N80 L81 Y84 L95 Q97 S99 F116 Y123 T143 K146 W147 S150 A152 H155 Y156 Y159 W167 Y171 Y7 E9 Y45 Y59 E63 K66 Q70 W73 V76 S77 N80 L81 Y84 L95 Q97 S99 F116 Y123 T143 K146 W147 S150 A152 H155 Y156 Y159 W167 Y171 GPHSMRYFETAVSRPGLEEPRYISVGYVDNKEFVRFDSDAENPRYEPRAPWMEQEGPEYWERETQKAKGQEQWFRVSLRNLLGYYNQSAGGSHTLQQMSGCDLGSDWRLLRGYLQFAYEGRDYIALNEDLKTWTAADMAAQITRRKWEQSGAAEHYKAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHPRSKGEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVYHEGLPEPLTLRWEP 5m01 G 1.95 BS01 III P 1 Y101 G102 N103 Y93 G94 N95 QQVRQSPQSLTVWEGGTTVLTCSYEDSTFNYFPWYQQFPGEGPALLISILSVSDKKEDGRFTTFFNKREKKLSLHIIDSQPGDSATYFCAALYGNEKITFGAGTKLTIKPNIQNPEPAVYQLKDPRSQDSTLCLFTDFDSQINVPKTMESGTFITDKCVLDMKAMDSKSNGAIAWSNQTSFTCQDIFK 5m01 H 1.95 BS01 III P 1 D93 A94 R97 N98 D93 A94 R97 N98 AVTQSPRSKVAVTGGKVTLSCHQTNNHDYMYWYRQDTGHGLRLIHYSYVADSTEKGDIPDGYKASRPSQENFSLILELASLSQTAVYFCASSDAGGRNTLYFGAGTRLSVLEDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVCTDPQAYKESNYSYSLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRAD 5mm3 A 2.10 BS01 MAL A 1 D14 K15 W62 A63 D65 R66 E111 E153 P154 Y155 F156 W340 D14 K15 W62 A63 D65 R66 E111 E153 P154 Y155 F156 W340 KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRLKEKRITNTEAAIDTGK 5mxv A 1.63 BS01 K3T A 1 W103 G106 I107 F110 F114 M142 W145 Y148 T149 N176 N179 E180 L183 W207 W82 G85 I86 F89 F93 M121 W124 Y127 T128 N155 N158 E159 L162 W186 29018348 GDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE 5myl A 1.72 BS01 Q2N A 1 W103 G106 I107 F110 W138 M142 W145 Y148 T149 V152 N176 N179 L183 F184 W207 W82 G85 I86 F89 W117 M121 W124 Y127 T128 V131 N155 N158 L162 F163 W186 29018348 GDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE 5mym B 2.28 BS01 HYV B 1 G106 I107 F110 F114 G124 Q125 R128 W138 M142 Y148 T149 N176 N179 E180 L183 F184 W207 G92 I93 F96 F100 G110 Q111 R114 W124 M128 Y134 T135 N162 N165 E166 L169 F170 W193 29018348 RRTARPSGDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE 5myn A 1.56 BS01 ZUF A 1 W103 G106 I107 F110 M142 W145 Y148 T149 N176 N179 E180 F184 W207 W82 G85 I86 F89 M121 W124 Y127 T128 N155 N158 E159 F163 W186 29018348 GDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE 5myr A 1.83 BS01 UDY A 1 W103 G106 I107 F110 F114 W138 M142 W145 Y148 T149 N176 N179 E180 L183 F184 W207 W82 G85 I86 F89 F93 W117 M121 W124 Y127 T128 N155 N158 E159 L162 F163 W186 29018348 GDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE 5myw A 1.77 BS01 WCU A 1 M102 W103 G106 F110 Y148 T149 N176 W207 M81 W82 G85 F89 Y127 T128 N155 W186 29018348 GDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE 5n8j A 1.05 BS01 DLE O 1 A86 S88 A73 S75 28935886 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKP 5n8j A 1.05 BS02 DSG O 1 W79 T90 W108 L110 W66 T77 W95 L97 28935886 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKP 5n8j A 1.05 BS03 DVA O 1 Y43 E44 S45 Y54 W79 Y30 E31 S32 Y41 W66 28935886 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKP 5n8j A 1.05 BS04 DGL O 1 N23 L25 S27 N10 L12 S14 28935886 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKP 5n8j A 1.05 BS05 DSN O 1 L25 S27 S45 A46 L12 S14 S32 A33 28935886 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKP 5n8j B 1.05 BS01 III E 1 N23 L25 S27 Y43 E44 S45 A46 W79 R84 A86 S88 T90 W108 L110 N9 L11 S13 Y29 E30 S31 A32 W65 R70 A72 S74 T76 W94 L96 28935886 AGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVK 5nbp A 1.80 BS01 CA A 1 D40 S80 D266 D6 S46 D232 29020628 ILFKDDFNFFDEKVWTKETHEPGWTNQELQAYDAAHVSVGKDGDKSVLILTAERKGNKIYSGRINSKGKKSFKYRKIEASIKLPKTNGGLWPAFWMMGDNDKQWPACGEIDIMEMGEQSGMAAGDSEKQVNTAIHYGPSAAAHEQQYYKANVANSLQDGNYHTYSLDWDENNLTISIDNVKFHTFDISSNTYFHDNFYILFNLAVGGAFTGITDINKLTGLKDGQKVNMYIDWVKIL 5nbp A 1.80 BS02 BGC A 1 N60 W125 A127 W129 E143 D145 E148 H169 Y181 N26 W91 A93 W95 E109 D111 E114 H135 Y147 29020628 ILFKDDFNFFDEKVWTKETHEPGWTNQELQAYDAAHVSVGKDGDKSVLILTAERKGNKIYSGRINSKGKKSFKYRKIEASIKLPKTNGGLWPAFWMMGDNDKQWPACGEIDIMEMGEQSGMAAGDSEKQVNTAIHYGPSAAAHEQQYYKANVANSLQDGNYHTYSLDWDENNLTISIDNVKFHTFDISSNTYFHDNFYILFNLAVGGAFTGITDINKLTGLKDGQKVNMYIDWVKIL 5nbp A 1.80 BS03 BGC A 2 T59 N60 R97 W129 M131 W138 T25 N26 R63 W95 M97 W104 29020628 ILFKDDFNFFDEKVWTKETHEPGWTNQELQAYDAAHVSVGKDGDKSVLILTAERKGNKIYSGRINSKGKKSFKYRKIEASIKLPKTNGGLWPAFWMMGDNDKQWPACGEIDIMEMGEQSGMAAGDSEKQVNTAIHYGPSAAAHEQQYYKANVANSLQDGNYHTYSLDWDENNLTISIDNVKFHTFDISSNTYFHDNFYILFNLAVGGAFTGITDINKLTGLKDGQKVNMYIDWVKIL 5nbp A 1.80 BS04 BGC A 3 W58 T59 W138 W24 T25 W104 29020628 ILFKDDFNFFDEKVWTKETHEPGWTNQELQAYDAAHVSVGKDGDKSVLILTAERKGNKIYSGRINSKGKKSFKYRKIEASIKLPKTNGGLWPAFWMMGDNDKQWPACGEIDIMEMGEQSGMAAGDSEKQVNTAIHYGPSAAAHEQQYYKANVANSLQDGNYHTYSLDWDENNLTISIDNVKFHTFDISSNTYFHDNFYILFNLAVGGAFTGITDINKLTGLKDGQKVNMYIDWVKIL 5nbp B 1.80 BS02 BGC B 1 N60 W125 A127 W129 E143 D145 E148 H169 N26 W91 A93 W95 E109 D111 E114 H135 29020628 ILFKDDFNFFDEKVWTKETHEPGWTNQELQAYDAAHVSVGKDGDKSVLILTAERKGNKIYSGRINSKGKKSFKYRKIEASIKLPKTNGGLWPAFWMMGDNDKQWPACGEIDIMEMGEQSGMAAGDSEKQVNTAIHYGPSAAAHEQQYYKANVANSLQDGNYHTYSLDWDENNLTISIDNVKFHTFDISSNTYFHDNFYILFNLAVGGAFTGITDINKLTGLKDGQKVNMYIDWVKIL 5nfz A 2.10 BS03 CA A 2 S158 G162 K166 S158 G162 K166 29023132 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV 5nfz B 2.10 BS01 8WB B 1 C241 L242 L248 A250 D251 L255 N258 M259 T314 A316 I318 N350 K352 A354 I378 C238 L239 L245 A247 D248 L252 N255 M256 T307 A309 I311 N343 K345 A347 I363 29023132 REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDAT 5ng1 B 2.20 BS03 8WE B 1 L217 H229 A233 F272 P274 L275 T276 P360 R369 L371 L215 H227 A231 F270 P272 L273 T274 P350 R351 L353 29023132 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSLTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDA 5ng1 D 2.20 BS03 ZPN D 1 H229 A233 F272 P274 L275 T276 R278 Q281 R284 L286 P360 R369 L371 H227 A231 F270 P272 L273 T274 R276 Q279 R282 L284 P358 R359 L361 29023132 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 5ng1 F 2.20 BS01 ACP F 1 K74 K150 Q183 K184 Y185 L186 K198 R202 T241 N242 D318 E331 N333 K74 K131 Q164 K165 Y166 L167 K179 R183 T222 N223 D299 E312 N314 29023132 MYTFVVRDENSSVYAEVSRLLLATGQWKRLRKDNPRFNLMLGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELSESCTWFPESYVIYPTNLTDEREVFLAAYNRRREGREGNVWIAKSSAGAKGEGILISSEASELLDFIDEQGQVHVIQKYLEKPLLLEPGHRKFDIRSWVLVDHLYNIYLYREGVLRTSSEPYNSANFQDKTCHLTNHCIQKEYSKNYGRYEEGNEMFFEEFNQYLMDALNTTLENSILLQIKHIIRSCLMCIEPAISTKHLHYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDVAISSVFPLAPTSIFIKLHH 5nn4 A 1.83 BS01 SC2 A 1 H432 G435 R436 R437 T834 H339 G342 R343 R344 T729 3.2.1.20 QCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLETAPSPLYSVEFSEEPFGVIVHRQLDGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLALEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPIEREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC 5nn4 A 1.83 BS02 SC2 A 2 H742 Q757 H649 Q664 3.2.1.20 QCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLETAPSPLYSVEFSEEPFGVIVHRQLDGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLALEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPIEREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC 5nn5 A 2.00 BS01 NOJ A 1 W376 D404 L405 I441 W516 D518 M519 R600 W613 D616 F649 H674 W283 D311 L312 I348 W423 D425 M426 R507 W520 D523 F556 H581 3.2.1.20 QCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLETAPSPLYSVEFSEEPFGVIVHRQLDGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLALEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPIEEPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC 5nn8 A 2.45 BS01 ACR A 1 D282 W376 D404 L405 I441 W516 D518 M519 R600 W613 D616 W618 F649 L650 H674 D188 W282 D310 L311 I347 W422 D424 M425 R506 W519 D522 W524 F555 L556 H580 3.2.1.20 QCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLEAPSPLYSVEFSEEPFGVIVHRQLDGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLALEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPIEEPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC 5nn8 A 2.45 BS02 ACR A 2 D91 A93 G123 Q124 P125 W126 C127 D11 A13 G36 Q37 P38 W39 C40 3.2.1.20 QCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLEAPSPLYSVEFSEEPFGVIVHRQLDGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLALEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPIEEPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC 5nur C 3.29 BS02 Z9M C 1 E212 R235 E212 R235 AEIYNKDGNKVDLYGKAVGLHYFSKGNGENSYGGNGDMTYARLGFKGETQINSDLTGYGQWEYNFQGNNSEGADAQTGNKTRLAFAGLKYADVGSFDYGRNYGVVYDALGYTDMLPEFGGDTAYSDDFFVGRVGGVATYRNSNFFGLVDGLNFAVQYLGKNERDTARRSNGDGVGGSISYEYEGFGIVGAYGAADRTNLQEAQPLGNGKKAEQWATGLKYDANNIYLAANYGETRNATPITNKFTNTSGFANKTQDVLLVAQYQFDFGLRPSIAYTKSKAKDVEGIGDVDLVNYFEVGATYYFNKNMSTYVDYIINQIDSDNKLGVGSDDTVAVGIVYQF 5nur A 3.29 BS02 Z9M A 1 E212 R235 K253 E212 R235 K253 AEIYNKDGNKVDLYGKAVGLHYFSKGNGENSYGGNGDMTYARLGFKGETQINSDLTGYGQWEYNFQGNNSEGADAQTGNKTRLAFAGLKYADVGSFDYGRNYGVVYDALGYTDMLPEFGGDTAYSDDFFVGRVGGVATYRNSNFFGLVDGLNFAVQYLGKNERDTARRSNGDGVGGSISYEYEGFGIVGAYGAADRTNLQEAQPLGNGKKAEQWATGLKYDANNIYLAANYGETRNATPITNKFTNTSGFANKTQDVLLVAQYQFDFGLRPSIAYTKSKAKDVEGIGDVDLVNYFEVGATYYFNKNMSTYVDYIINQIDSDNKLGVGSDDTVAVGIVYQF 5nur E 3.29 BS01 Z9M E 1 R235 K253 R235 K253 AEIYNKDGNKVDLYGKAVGLHYFSKGNGENSYGGNGDMTYARLGFKGETQINSDLTGYGQWEYNFQGNNSEGADAQTGNKTRLAFAGLKYADVGSFDYGRNYGVVYDALGYTDMLPEFGGDTAYSDDFFVGRVGGVATYRNSNFFGLVDGLNFAVQYLGKNERDTARRSNGDGVGGSISYEYEGFGIVGAYGAADRTNLQEAQPLGNGKKAEQWATGLKYDANNIYLAANYGETRNATPITNKFTNTSGFANKTQDVLLVAQYQFDFGLRPSIAYTKSKAKDVEGIGDVDLVNYFEVGATYYFNKNMSTYVDYIINQIDSDNKLGVGSDDTVAVGIVYQF 5o1u A 1.90 BS01 MN A 1 H19 D23 D80 H21 D25 D82 SGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVDASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATDTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEG 5o1u A 1.90 BS02 MN A 2 D25 D80 H104 D154 D27 D82 H106 D156 SGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVDASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATDTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEG 5o1u A 1.90 BS03 MN A 3 H105 H286 H107 H288 SGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVDASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATDTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEG 5o1u A 1.90 BS04 AMP A 1 R86 H105 H263 S265 R267 G283 G284 G285 H286 A290 G291 T293 R88 H107 H265 S267 R269 G285 G286 G287 H288 A292 G293 T295 SGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVDASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATDTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEG 5o1u B 1.90 BS04 CA B 1 D85 G282 D87 G284 SGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVDASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATDTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEGVE 5o25 A 1.75 BS01 MN A 1 H19 D23 D25 D80 H21 D25 D27 D82 SGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVDASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATDTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEG 5o25 B 1.75 BS02 MN B 1 H19 D23 D25 C26 D80 H22 D26 D28 C29 D83 GSGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVDASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATDTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEGVES 5o25 B 1.75 BS03 MN B 2 D25 D80 H104 H105 D154 D28 D83 H107 H108 D157 GSGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVDASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATDTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEGVES 5o4z A 1.70 BS01 A A 1 H105 H263 S265 R267 G283 G284 G285 H286 A289 A290 G291 V292 T293 H108 H266 S268 R270 G286 G287 G288 H289 A292 A293 G294 V295 T296 GSGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVNASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATNTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEGVES 5o4z A 1.70 BS02 A A 2 H104 H105 T153 N154 H160 S161 N162 R267 H286 R288 A289 H107 H108 T156 N157 H163 S164 N165 R270 H289 R291 A292 GSGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVNASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATNTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEGVES 5o58 A 1.55 BS01 NUC B 1 H104 H105 T153 N154 H160 N162 R243 H263 S265 R267 G283 G284 H286 R288 A289 A290 G291 V292 T293 H107 H108 T156 N157 H163 N165 R246 H266 S268 R270 G286 G287 H289 R291 A292 A293 G294 V295 T296 GSGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVNASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATNTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEGVES 5o7f A 1.90 BS02 MN A 1 H19 D23 C26 N80 H21 D25 C28 N82 SGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVNASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATNTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEGVE 5oam A 5.50 BS01 GTP A 1 G10 Q11 A12 A99 A100 N101 G143 G144 T145 G146 G9 Q10 A11 A72 A73 N74 G116 G117 T118 G119 RECISIHVGQAGVQIGNACWELYCLEHGIQPDGHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRGHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDS 5oam B 5.50 BS01 GDP B 1 G10 Q11 C12 G142 G143 G144 T145 G146 G9 Q10 C11 G139 G140 G141 T142 G143 REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQD 5oam B 5.50 BS02 TA1 B 1 E22 V23 D226 L230 A233 P274 L275 T276 R278 P360 R369 G370 E21 V22 D223 L227 A230 P271 L272 T273 R275 P357 R358 G359 REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQD 5ocu K 5.20 BS01 ANP K 1 V18 R19 A114 T115 G116 A117 G118 K119 T120 H121 S225 S226 G261 V9 R10 A82 T83 G84 A85 G86 K87 T88 H89 S193 S194 G229 HHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLN 5odj A 1.50 BS01 MG A 1 K11 N12 T57 H58 A60 I61 K10 N11 T51 H52 A54 I55 EKLVPAKKVKNGVLYKSGHIKVSNVRCSYPHLDKPYGEPKYSITLLMPKDTHGAIKKIIDEQIELTKKNHKTGALKVAPSMLFIKDGDVDFPECEGMWVISARESTRPDVLNMEREELESPNEIAEEIYGGCWVSSVIRPWSQENKYGKRINANLLSVLKRKDDEPFGEGRVDTSDAYD 5odl A 1.56 BS01 NUC D 1 S29 Y30 H32 Y37 K46 T50 F97 K100 C103 S110 R112 W150 Q152 N154 Y156 R159 N161 N163 L165 S29 Y30 H32 Y37 K46 T50 F97 K100 C103 S110 R112 W150 Q152 N154 Y156 R159 N161 N163 L165 AEKLVPAKKVKNGVLYKSGHIKVSNVRCSYPHLDKPYGGEDGGEPKYSITLLMPKDTHGAIKKIIDEQIELTKKNHKTGALKVAPSMLFIKDGDVDFPDKPECEGMWVISARESTRPDVLNMEREELESPNEIAEEIYGGCWVSSVIRPWSQENKYGKRINANLLSVLKRKDDEPFG 5ogc K 4.80 BS01 9V5 K 1 L124 G125 M133 Y134 Y159 L207 N211 R214 S225 A230 D258 L95 G96 M104 Y105 Y130 L178 N182 R185 S196 A201 D229 HHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKS 5ogc A 4.80 BS02 GTP A 1 G10 Q11 A12 Q15 A99 A100 N101 S140 G143 G144 T145 G146 I171 N206 Y224 N228 G9 Q10 A11 Q14 A72 A73 N74 S113 G116 G117 T118 G119 I144 N179 Y197 N201 RECISIHVGQAGVQIGNACWELYCLEHGIQPDGHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRGHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDS 5ogc B 4.80 BS03 TA1 B 1 E22 V23 D26 E27 D226 H229 L230 A233 S236 F272 P274 L275 T276 R278 P360 R369 G370 E21 V22 D25 E26 D223 H226 L227 A230 S233 F269 P271 L272 T273 R275 P357 R358 G359 REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQD 5ogl A 2.70 BS01 III B 1 T53 T54 N55 D56 N146 R147 Y152 E315 T316 I317 M318 E319 N321 R331 L374 W463 W464 D465 G482 H485 V575 T52 T53 N54 D55 N145 R146 Y151 E314 T315 I316 M317 E318 N320 R330 L373 W462 W463 D464 G481 H484 V574 2.4.99.19 ELQQNFTDNNSIKYTAILILIAFAFSVLARLYWVAWASEFYEFFFNDQLMITTNDGYAFAEGARDMIAGFHQPNDLSYFGSSLSTLTYWLYSILPFSFESIILYMSTFFASLIVVPIILIAREYKLTTYGFIAALLGSIANSYYNRTMSGYYDTDMLVLVLPMLILLTFIRLTINKDIFTLLLSPVFIMIYLWWYPSSYSLNFAMIGLFGLYTLVFHRKEKIFYLTIALMIIALSMLAWQYKLALIVLLFAIFAFKEEKINFYMIWALIFISILILHLSGGLDPVLYQLKFYVFKASDVQNLKDAAFMYFNVNETIMEVNTIDPEVFMQRISSSVLVFILSFIGFILLLKDHKSMLLALPMLALGFMALRAGLRFTIYAVPVMALGFGYFLYAFFNFLEKKQIKLSLRNKNILLILIAFFSISPALMHIYYYKSSTVFTSYEASILNDLKNKAQREDYVVAWWDYGYPIRYYSDVKTLIDGGKHLGKDNFFSSFVLSKEQIPAANMARLSVEYTEKSFKENYPDVLKAMVKDYQKTSAKDFLESLNDPNFKIDTPKTRDVYIYMPYRMLRIMPVVAQFANTNPDNGEQEKSLFFSQANPLDQDGSITLDNGVEISNDYRSLKIEGNSIPLKAFVDIESITNGKFYYNEIDSKAQIYLLYLREYKSYVILDESLYNSSYIQMFLLNQYDQDLFEQITNDTRAKIYRLK 5ogl A 2.70 BS03 MN A 2 E62 R65 Q73 D76 D475 E61 R64 Q72 D75 D474 2.4.99.19 ELQQNFTDNNSIKYTAILILIAFAFSVLARLYWVAWASEFYEFFFNDQLMITTNDGYAFAEGARDMIAGFHQPNDLSYFGSSLSTLTYWLYSILPFSFESIILYMSTFFASLIVVPIILIAREYKLTTYGFIAALLGSIANSYYNRTMSGYYDTDMLVLVLPMLILLTFIRLTINKDIFTLLLSPVFIMIYLWWYPSSYSLNFAMIGLFGLYTLVFHRKEKIFYLTIALMIIALSMLAWQYKLALIVLLFAIFAFKEEKINFYMIWALIFISILILHLSGGLDPVLYQLKFYVFKASDVQNLKDAAFMYFNVNETIMEVNTIDPEVFMQRISSSVLVFILSFIGFILLLKDHKSMLLALPMLALGFMALRAGLRFTIYAVPVMALGFGYFLYAFFNFLEKKQIKLSLRNKNILLILIAFFSISPALMHIYYYKSSTVFTSYEASILNDLKNKAQREDYVVAWWDYGYPIRYYSDVKTLIDGGKHLGKDNFFSSFVLSKEQIPAANMARLSVEYTEKSFKENYPDVLKAMVKDYQKTSAKDFLESLNDPNFKIDTPKTRDVYIYMPYRMLRIMPVVAQFANTNPDNGEQEKSLFFSQANPLDQDGSITLDNGVEISNDYRSLKIEGNSIPLKAFVDIESITNGKFYYNEIDSKAQIYLLYLREYKSYVILDESLYNSSYIQMFLLNQYDQDLFEQITNDTRAKIYRLK 5ogl A 2.70 BS04 9UB A 1 D56 A59 F60 Y79 Y196 S198 S201 V286 Q289 Y293 L365 M368 R375 F376 Y379 Y468 D55 A58 F59 Y78 Y195 S197 S200 V285 Q288 Y292 L364 M367 R374 F375 Y378 Y467 2.4.99.19 ELQQNFTDNNSIKYTAILILIAFAFSVLARLYWVAWASEFYEFFFNDQLMITTNDGYAFAEGARDMIAGFHQPNDLSYFGSSLSTLTYWLYSILPFSFESIILYMSTFFASLIVVPIILIAREYKLTTYGFIAALLGSIANSYYNRTMSGYYDTDMLVLVLPMLILLTFIRLTINKDIFTLLLSPVFIMIYLWWYPSSYSLNFAMIGLFGLYTLVFHRKEKIFYLTIALMIIALSMLAWQYKLALIVLLFAIFAFKEEKINFYMIWALIFISILILHLSGGLDPVLYQLKFYVFKASDVQNLKDAAFMYFNVNETIMEVNTIDPEVFMQRISSSVLVFILSFIGFILLLKDHKSMLLALPMLALGFMALRAGLRFTIYAVPVMALGFGYFLYAFFNFLEKKQIKLSLRNKNILLILIAFFSISPALMHIYYYKSSTVFTSYEASILNDLKNKAQREDYVVAWWDYGYPIRYYSDVKTLIDGGKHLGKDNFFSSFVLSKEQIPAANMARLSVEYTEKSFKENYPDVLKAMVKDYQKTSAKDFLESLNDPNFKIDTPKTRDVYIYMPYRMLRIMPVVAQFANTNPDNGEQEKSLFFSQANPLDQDGSITLDNGVEISNDYRSLKIEGNSIPLKAFVDIESITNGKFYYNEIDSKAQIYLLYLREYKSYVILDESLYNSSYIQMFLLNQYDQDLFEQITNDTRAKIYRLK 5oop A 1.70 BS01 ANP A 1 G16 E17 G18 A19 V23 A36 K38 M84 E85 A87 L137 D148 S150 G12 E13 G14 A15 V19 A32 K34 M74 E75 A77 L127 D138 S140 2.7.11.1 29023112 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDCPENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKK 5oor A 1.90 BS01 STU A 1 L15 G16 E17 V23 A36 M84 E85 L86 A87 G90 H134 L137 D148 L13 G14 E15 V21 A34 M74 E75 L76 A77 G80 H124 L127 D138 2.7.11.1 29023112 VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMNIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGV 5oot A 2.10 BS01 4K4 A 1 Q13 T14 L15 V23 A36 M84 E85 L86 A87 S88 G90 H134 N135 L137 A147 Q10 T11 L12 V20 A33 M74 E75 L76 A77 S78 G80 H124 N125 L127 A137 2.7.11.1 29023112 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 5op2 A 1.90 BS01 A0Q A 1 L15 G16 E17 G18 V23 A36 M84 E85 L86 A87 S88 G90 H134 N135 L137 L12 G13 E14 G15 V20 A33 M76 E77 L78 A79 S80 G82 H126 N127 L129 2.7.11.1 29023112 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMCPENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKK 5op4 A 2.00 BS01 A0T A 1 T14 L15 V23 A36 M84 E85 L86 A87 S88 G90 L137 A147 T12 L13 V21 A34 M73 E74 L75 A76 S77 G79 L126 A136 2.7.11.1 29023112 VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDNIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 5op5 A 1.90 BS01 3FE A 1 G16 G18 V23 A36 K38 M84 E85 L86 A87 L137 D148 G13 G15 V20 A33 K35 M73 E74 L75 A76 L126 D137 2.7.11.1 29023112 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMNIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 5opb A 1.55 BS01 A1N A 1 L15 E17 G18 V23 A36 M84 E85 L86 A87 G90 H134 N135 L137 L11 E13 G14 V19 A32 M75 E76 L77 A78 G81 H125 N126 L128 2.7.11.1 29023112 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMCPENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKK 5opr A 1.95 BS01 A3E A 1 L15 A36 M84 E85 L86 A87 G90 D94 N135 L137 D148 L12 A33 M72 E73 L74 A75 G78 D82 N123 L125 D136 2.7.11.1 29023112 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDNIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 5ops A 2.00 BS01 A3Q A 1 L15 G16 V23 A36 M84 E85 L86 A87 L137 L13 G14 V21 A34 M72 E73 L74 A75 L125 2.7.11.1 29023112 VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVNIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 5opu A 1.55 BS01 A3K A 1 G16 E17 V23 A36 M84 E85 A87 N135 L137 G14 E15 V21 A34 M74 E75 A77 N125 L127 2.7.11.1 29023112 VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMNIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKK 5opv A 1.90 BS01 A3H A 1 L15 V23 A36 M84 E85 A87 G90 N135 L137 L13 V21 A34 M75 E76 A78 G81 N126 L128 2.7.11.1 29023112 VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 5oq5 A 1.40 BS01 4K4 A 1 L15 V23 A36 M84 E85 L86 A87 S88 G89 G90 H134 N135 L137 A147 L13 V21 A34 M79 E80 L81 A82 S83 G84 G85 H129 N130 L132 A142 2.7.11.1 29023112 VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRCPENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 5oq6 A 1.95 BS01 4K4 A 1 T14 L15 V23 A36 M84 E85 L86 A87 S88 H134 N135 L137 A147 T10 L11 V19 A32 M71 E72 L73 A74 S75 H121 N122 L124 A134 2.7.11.1 29023112 FVEDWDLVQTLGEGSFGEVQLAVNRVTEEAVAVKIVDNIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 5oq7 A 2.10 BS01 A0Q A 1 L15 G16 E17 G18 V23 A36 I68 M84 E85 A87 G90 H134 N135 L137 L8 G9 E10 G11 V16 A29 I56 M72 E73 A75 G78 H122 N123 L125 2.7.11.1 29023112 DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMCPENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKK 5oq7 B 2.10 BS01 A0Q B 1 L15 G16 E17 V23 A36 M84 E85 A87 G90 H134 N135 L137 L8 G9 E10 V14 A27 M70 E71 A73 G76 H120 N121 L123 2.7.11.1 29023112 DWDLVQTLGEGGEVQLAVNRVTEEAVAVKIVDMCPENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 5owu A 2.00 BS01 III B 1 N223 M226 Q227 C230 E231 K260 Y262 M263 E264 Q265 A266 Y268 A269 L270 Y315 F317 S320 S321 N223 M226 Q227 C230 E231 K260 Y262 M263 E264 Q265 A266 Y268 A269 L270 Y315 F317 S320 S321 15878174 MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKRQLSL 5owu A 2.00 BS02 III B 2 N178 L181 I182 V185 Q186 E221 Y224 Q227 N178 L181 I182 V185 Q186 E221 Y224 Q227 15878174 MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKRQLSL 5tle A 1.58 BS01 RD1 A 1 A31 D33 E34 S35 S38 K107 R148 K229 L270 S271 G272 S300 Y301 G302 R303 A31 D33 E34 S35 S38 K107 R148 K229 L270 S271 G272 S300 Y301 G302 R303 4.1.2.13 PHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSNHAY 5tlh A 2.20 BS01 RD2 A 1 E34 R42 S45 R303 E34 R42 S45 R303 4.1.2.13 PHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSSNHAY 5tlh A 2.20 BS02 MDN A 1 S38 K107 K146 R148 S38 K107 K146 R148 4.1.2.13 PHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSSNHAY 5tlh B 2.20 BS01 RD2 B 1 E34 R42 S45 R303 K311 E34 R42 S45 R303 K311 4.1.2.13 PHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSNHAY 5tlh B 2.20 BS02 MDN B 1 D33 S35 S38 K107 K146 R148 D33 S35 S38 K107 K146 R148 4.1.2.13 PHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSNHAY 5tlh C 2.20 BS01 RD2 C 1 E34 R42 S45 R303 Q306 K311 E34 R42 S45 R303 Q306 K311 4.1.2.13 PHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGSNHAY 5tlh D 2.20 BS01 RD2 D 1 E34 R42 S45 R303 Q306 L310 K311 E34 R42 S45 R303 Q306 L310 K311 4.1.2.13 PHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTP 5tlw A 2.29 BS01 RD3 A 1 E34 S35 S38 K107 K146 R148 R303 E34 S35 S38 K107 K146 R148 R303 4.1.2.13 PHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSNHAY 5tlw B 2.29 BS01 RD3 B 1 E34 S35 S38 K41 K107 K146 R148 R303 E34 S35 S38 K41 K107 K146 R148 R303 4.1.2.13 PHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSNHAY 5tlz A 1.97 BS01 N26 A 1 A31 D33 S35 S38 K107 R148 S271 G272 G302 R303 A28 D30 S32 S35 K104 R145 S268 G269 G299 R300 4.1.2.13 HPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSNHAY 5tlz B 1.97 BS01 N26 B 1 A31 D33 S35 S38 K107 R148 K229 L270 S271 G272 S300 Y301 G302 A28 D30 S32 S35 K104 R145 K226 L267 S268 G269 S297 Y298 G299 4.1.2.13 HPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSNHAY 5tpk A 2.00 BS01 CA A 1 E708 E709 N757 E759 D793 E19 E20 N68 E70 D104 NDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTSFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEASITFLAEAFDIYGTMPPGIATVTVIVKD 5tpk A 2.00 BS02 CA A 2 E708 E759 D790 I791 D793 N794 D826 E19 E70 D101 I102 D104 N105 D137 NDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTSFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEASITFLAEAFDIYGTMPPGIATVTVIVKD 5tpk A 2.00 BS03 CA A 3 D792 N794 D824 D826 D103 N105 D135 D137 NDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTSFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEASITFLAEAFDIYGTMPPGIATVTVIVKD 5tpk A 2.00 BS04 CA A 4 N690 N692 D722 D724 N728 D772 N1 N3 D33 D35 N39 D83 NDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTSFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEASITFLAEAFDIYGTMPPGIATVTVIVKD 5tps B 2.70 BS01 GAL B 1 P244 K246 E258 T260 P6 K8 E20 T22 SVFLFPPKPKDTLMISRTPEVTCVVEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFKLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS 5tsf A 2.29 BS02 7KO A 2 T36 Y55 Q57 V108 M116 I118 T39 Y58 Q60 V111 M119 I121 DKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERR 5tsf D 2.29 BS02 7KO E 1 T36 Y55 V108 I118 T39 Y58 V111 I121 DKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERR 5tsf E 2.29 BS01 7KO A 1 T36 Y55 Q57 V108 I118 T45 Y64 Q66 V117 I127 DYKDDDDKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERR 5ug1 A 2.10 BS01 03S A 1 D437 S438 V439 V460 N491 H571 D11 S12 V13 V34 N65 H145 2.3.1.- GIADGTMLIGDSVALRANTALQTALPGAQINAQVSVTTKTANEIMLNNSQNKFLPKTVVIATGVNNPENYKDDWDSIVKNLPKGHHMILVTPYEGDKTKETYAIVEKAAAYMRELAEKTPYITIADWNQVAKEHPEIWAGTDQVHFGSESSTIEAGAKLYADTIATALQTAQDKPVKSK 5uqv A 2.84 BS01 8JM A 1 Q297 C300 R301 L304 D305 E308 I320 P321 F324 Y348 D349 H403 Q405 Q88 C91 R92 L95 D96 E99 I111 P112 F115 Y139 D140 H194 Q196 3.4.19.12 29045385 HTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQ 5uqx A 2.23 BS01 8JP A 1 Q297 C300 R301 D305 E308 I320 Y348 D349 H403 Q89 C92 R93 D97 E100 I112 Y140 D141 H195 3.4.19.12 29045385 KHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQK 5uqx B 2.23 BS01 8JP B 1 Q297 C300 R301 L304 D305 E308 N309 I320 Y348 D349 H403 Q90 C93 R94 L97 D98 E101 N102 I113 Y141 D142 H196 3.4.19.12 29045385 KKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKR 5vbe A 1.57 BS01 GDP A 1 G13 V14 G15 K16 S17 A18 F28 V29 D30 N116 K117 D119 L120 S145 A146 K147 G13 V14 G15 K16 S17 A18 F28 V29 D30 N113 K114 D116 L117 S142 A143 K144 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQSAMRDQYCRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQH 5vbe A 1.57 BS02 92V A 1 Q61 R68 C72 F78 D92 Q95 Y96 Q99 Q61 R65 C69 F75 D89 Q92 Y93 Q96 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQSAMRDQYCRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQH 5vbm A 1.49 BS02 92V A 1 R68 C72 F78 H95 Y96 Q99 I100 R67 C71 F77 H94 Y95 Q98 I99 GMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETSLLDILDTAGEYSAMRDQYCRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEK 5vbz B 2.20 BS01 GNP B 1 G12 G13 G15 K16 S17 A18 F28 V29 D30 G60 N116 K117 D119 L120 S145 A146 K147 G12 G13 G15 K16 S17 A18 F28 V29 D30 G60 N114 K115 D117 L118 S143 A144 K145 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGEYSAMRDQYCRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQH 5vbz C 2.20 BS01 92V C 1 C72 F78 Q95 Y96 Q99 C70 F76 Q93 Y94 Q97 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGEYSAMRDQYCRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQH 5vbz C 2.20 BS02 GNP C 1 G12 G13 V14 G15 K16 S17 A18 F28 V29 T35 G60 N116 K117 D119 L120 S145 A146 K147 G12 G13 V14 G15 K16 S17 A18 F28 V29 T35 G60 N114 K115 D117 L118 S143 A144 K145 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGEYSAMRDQYCRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQH 5vcl A 2.05 BS01 III P 1 Y7 H9 M45 E63 K66 A67 M70 N73 F74 N77 T80 Y84 W97 Y99 E116 I124 W133 S143 K146 V150 E152 Q155 Q156 Y159 W167 Y171 Y7 H9 M45 E63 K66 A67 M70 N73 F74 N77 T80 Y84 W97 Y99 E116 I124 W133 S143 K146 V150 E152 Q155 Q156 Y159 W167 Y171 28767728 SSHSLRYFHTAMSRPGLGEPRFIVVGYVDDTQFVSFDSDSENPKMEPRARWMEQEGPEYWERETWKARDMGRNFRVNLRTLLGYYNQSKDESHTLQWMYGCDVGPDGRLLRGYCQEAYDGQDYISLNEDLRSWTATDFASQISKHKSEMVDEAHQQRAYLQGPCVEWLHTYLRLGNKTLKRSDPPKAHVTHHPRSEDYVTLRCWALGFYPADITLTWQLNGEELTQDMEFVETRPAGDGNFQKWASVVVPLGKEQNYTCHVEHEGLPEPLTLRWEPP 5vhv A 1.80 BS01 NUC C 1 R152 E156 R159 Y192 N199 N202 K206 R235 K301 S302 K309 T337 Y341 R148 E152 R155 Y188 N195 N198 K202 R231 K297 S298 K305 T333 Y337 AAPALKEIFNVERLQHIASEMTAVYPAFDAKGFLKHAKAGLAELSVMQRMARVSESLHAVIPLDYPQTLTLLYALAPRLNSGFVSLFLPHYVASYGRDDFKRSMAALKYFTTFGSAEFAIRHFLLHDFQRTLAVMQAWSQDDNEHVRRLASEGSRPRLPWSFRLAEVQADPELCASILDHLKADSSLYVRKSVANHLNDITKDHPEWVLSLIEGWNLENPHTAWIARHALRSLIKQGNTRALTLMGAGAKAEVKIHHLMVTPAVINLGERINLSFTLESTAPAPQKLVVDYAIDYVKSTGHGAAKVFKLKAFSLGAGAQQHIRREQHIRDMTTRKHYPGRHVVHVLVNGERLGSAEFELRA 5vhv A 1.80 BS02 NUC D 1 A8 L9 K10 S49 V50 M51 W164 S165 F166 R167 H232 F311 K312 M335 T336 T337 R338 A4 L5 K6 S45 V46 M47 W160 S161 F162 R163 H228 F307 K308 M331 T332 T333 R334 AAPALKEIFNVERLQHIASEMTAVYPAFDAKGFLKHAKAGLAELSVMQRMARVSESLHAVIPLDYPQTLTLLYALAPRLNSGFVSLFLPHYVASYGRDDFKRSMAALKYFTTFGSAEFAIRHFLLHDFQRTLAVMQAWSQDDNEHVRRLASEGSRPRLPWSFRLAEVQADPELCASILDHLKADSSLYVRKSVANHLNDITKDHPEWVLSLIEGWNLENPHTAWIARHALRSLIKQGNTRALTLMGAGAKAEVKIHHLMVTPAVINLGERINLSFTLESTAPAPQKLVVDYAIDYVKSTGHGAAKVFKLKAFSLGAGAQQHIRREQHIRDMTTRKHYPGRHVVHVLVNGERLGSAEFELRA 5vhv A 1.80 BS03 9B4 D 1 F87 L90 W164 F83 L86 W160 AAPALKEIFNVERLQHIASEMTAVYPAFDAKGFLKHAKAGLAELSVMQRMARVSESLHAVIPLDYPQTLTLLYALAPRLNSGFVSLFLPHYVASYGRDDFKRSMAALKYFTTFGSAEFAIRHFLLHDFQRTLAVMQAWSQDDNEHVRRLASEGSRPRLPWSFRLAEVQADPELCASILDHLKADSSLYVRKSVANHLNDITKDHPEWVLSLIEGWNLENPHTAWIARHALRSLIKQGNTRALTLMGAGAKAEVKIHHLMVTPAVINLGERINLSFTLESTAPAPQKLVVDYAIDYVKSTGHGAAKVFKLKAFSLGAGAQQHIRREQHIRDMTTRKHYPGRHVVHVLVNGERLGSAEFELRA 5vhv B 1.80 BS03 9B4 F 1 L9 G86 F87 L90 G118 W164 L5 G82 F83 L86 G114 W160 AAPALKEIFNVERLQHIASEMTAVYPAFDAKGFLKHAKAGLAELSVMQRMARVSESLHAVIPLDYPQTLTLLYALAPRLNSGFVSLFLPHYVASYGRDDFKRSMAALKYFTTFGSAEFAIRHFLLHDFQRTLAVMQAWSQDDNEHVRRLASEGSRPRLPWSFRLAEVQADPELCASILDHLKADSSLYVRKSVANHLNDITKDHPEWVLSLIEGWNLENPHTAWIARHALRSLIKQGNTRALTLMGAGAKAEVKIHHLMVTPAVINLGERINLSFTLESTAPAPQKLVVDYAIDYVKSTGHGAAKVFKLKAFSLGAGAQQHIRREQHIRDMTTRKHYPGRHVVHVLVNGERLGSAEFELRA 5vi0 A 2.40 BS01 NUC E 1 A8 L9 W164 S165 F166 R167 F311 K312 M335 T336 T337 R338 A4 L5 W160 S161 F162 R163 F303 K304 M327 T328 T329 R330 AAPALKEIFNVERLQHIASEMTAVYPAFDAKGFLKHAKAGLAELSVMQRMARVSESLHAVIPLDYPQTLTLLYALAPRLNSGFVSLFLPHYVASYGRDDFKRSMAALKYFTTFGSAEFAIRHFLLHDFQRTLAVMQAWSQDDNEHVRRLASEGSRPRLPWSFRLAEVQADPELCASILDHLKADSSLYVRKSVANHLNDITKDHPEWVLSLIEGWNLENPHTAWIARHALRSLIKQGNTRALTLMGAEVKIHHLMVTPAVINLGERINLSFTLESTAPAPQKLVVDYAIDYVKSTGHGAAKVFKLKAFSLGAGAQQHIRREQHIRDMTTRKHYPGRHVVHVLVNGERLGSAEFELRA 5vi0 A 2.40 BS02 NUC F 1 R159 K195 N199 N202 K206 W228 H232 R235 S302 T337 R338 K339 Y341 R155 K191 N195 N198 K202 W224 H228 R231 S294 T329 R330 K331 Y333 AAPALKEIFNVERLQHIASEMTAVYPAFDAKGFLKHAKAGLAELSVMQRMARVSESLHAVIPLDYPQTLTLLYALAPRLNSGFVSLFLPHYVASYGRDDFKRSMAALKYFTTFGSAEFAIRHFLLHDFQRTLAVMQAWSQDDNEHVRRLASEGSRPRLPWSFRLAEVQADPELCASILDHLKADSSLYVRKSVANHLNDITKDHPEWVLSLIEGWNLENPHTAWIARHALRSLIKQGNTRALTLMGAEVKIHHLMVTPAVINLGERINLSFTLESTAPAPQKLVVDYAIDYVKSTGHGAAKVFKLKAFSLGAGAQQHIRREQHIRDMTTRKHYPGRHVVHVLVNGERLGSAEFELRA 5vi0 A 2.40 BS03 P4K A 1 S85 G86 F87 H149 P163 W164 Y192 S81 G82 F83 H145 P159 W160 Y188 AAPALKEIFNVERLQHIASEMTAVYPAFDAKGFLKHAKAGLAELSVMQRMARVSESLHAVIPLDYPQTLTLLYALAPRLNSGFVSLFLPHYVASYGRDDFKRSMAALKYFTTFGSAEFAIRHFLLHDFQRTLAVMQAWSQDDNEHVRRLASEGSRPRLPWSFRLAEVQADPELCASILDHLKADSSLYVRKSVANHLNDITKDHPEWVLSLIEGWNLENPHTAWIARHALRSLIKQGNTRALTLMGAEVKIHHLMVTPAVINLGERINLSFTLESTAPAPQKLVVDYAIDYVKSTGHGAAKVFKLKAFSLGAGAQQHIRREQHIRDMTTRKHYPGRHVVHVLVNGERLGSAEFELRA 5vi0 B 2.40 BS01 NUC C 1 R159 K195 N199 N202 K206 R235 S236 K301 S302 A307 K309 T337 Y341 R153 K189 N193 N196 K200 R229 S230 K295 S296 A301 K303 T331 Y335 PALKEIFNVERLQHIASEMTAVYPAFDAKGFLKHAKAGLAELSVMQRMARVSESLHAVIPLDYPQTLTLLYALAPRLNSGFVSLFLPHYVASYGRDDFKRSMAALKYFTTFGSAEFAIRHFLLHDFQRTLAVMQAWSQDDNEHVRRLASEGSRPRLPWSFRLAEVQADPELCASILDHLKADSSLYVRKSVANHLNDITKDHPEWVLSLIEGWNLENPHTAWIARHALRSLIKQGNTRALTLMGAGAKAEVKIHHLMVTPAVINLGERINLSFTLESTAPAPQKLVVDYAIDYVKSTGHGAAKVFKLKAFSLGAGAQQHIRREQHIRDMTTRKHYPGRHVVHVLVNGERLGSAEFELRA 5vi0 B 2.40 BS02 NUC D 1 P7 A8 L9 K10 S49 V50 M51 W164 S165 F166 R167 W228 R231 F311 K312 M335 T336 T337 R338 P1 A2 L3 K4 S43 V44 M45 W158 S159 F160 R161 W222 R225 F305 K306 M329 T330 T331 R332 PALKEIFNVERLQHIASEMTAVYPAFDAKGFLKHAKAGLAELSVMQRMARVSESLHAVIPLDYPQTLTLLYALAPRLNSGFVSLFLPHYVASYGRDDFKRSMAALKYFTTFGSAEFAIRHFLLHDFQRTLAVMQAWSQDDNEHVRRLASEGSRPRLPWSFRLAEVQADPELCASILDHLKADSSLYVRKSVANHLNDITKDHPEWVLSLIEGWNLENPHTAWIARHALRSLIKQGNTRALTLMGAGAKAEVKIHHLMVTPAVINLGERINLSFTLESTAPAPQKLVVDYAIDYVKSTGHGAAKVFKLKAFSLGAGAQQHIRREQHIRDMTTRKHYPGRHVVHVLVNGERLGSAEFELRA 5vkl A 2.20 BS01 III B 1 K1355 S1379 Y1381 N1386 W1392 I1399 N1400 K1404 Y1406 W1408 N1409 I1428 N1432 K1435 L1438 K1439 S1442 N1445 R1446 K106 S130 Y132 N137 W143 I150 N151 K155 Y157 W159 N160 I179 N183 K186 L189 K190 S193 N196 R197 28826505 THRVINHPYYFPFNGRQAEDYLRSKERGEFVIRQSSRGDDHLVITWKLDKDLFQHIDIQELEKENPLALGKVLIVDNQKYNDLDQIIVEYLQNKVRLLNEMTSSEKFKSGTKKDVVKFIEDYSRVNPNKSVYYFSLNHDNPGWFYLMFKINANSKLYTWNVKLTNTGYFLVNYNYPSVIQLCNGFKTLLKSNSSKNRMNNYR 5vxe A 1.66 BS01 CER A 1 A142 C143 L253 H285 V287 H291 N315 I345 G346 S347 A129 C130 L227 H259 V261 H265 N289 I319 G320 S321 29025976 LVPRGSHMLFQNVSIAGLAHIDAPHTLTSKEINERLQPTYDRLGIKTDVLGDVAGIHARRLWDQDVQASDAATQAARKALIDANIGIEKIGLLINTSVSRDYLAPSTASIVSGNLGVSDHCMTFDVANACLAFINGMDIAARMLERGEIDYALVVDGETANLVYEKTLERMTSTEEEFRNELAALTLGCGAAAMVMARSELVPDAPRYKGGVTRSATEWNKLDTRLLLIEGIKLAQKTFVAAKQVLGWAVEELDQFVIHQVSRPHTAAFVKSFGIDPAKVMTIFGEHGNIGPASVPIVLSKLKELGRLKKGDRIALLGIGSGLNCSMAEVVW 5vxg A 2.07 BS01 CER A 1 A142 C143 L253 L254 I258 H285 V287 H291 N315 I345 G346 S347 A129 C130 L226 L227 I231 H258 V260 H264 N288 I318 G319 S320 29025976 LVPRGSHMLFQNVSIAGLAHIDAPHTLTSKEINERLQPTYDRLGIKTDVLGDVAGIHARRLWDQDVQASDAATQAARKALIDANIGIEKIGLLINTSVSRDYLQPSTASIVSGNLGVSDHCMTFDVANACLAFINGMDIAARMLERGEIDYALVVDGETANLVYEKTLERMTSTEEEFRNELAALTLGCGAAAMVMARSELVPDAPRYKGGVTRSATEWNKLTRLLLIEGIKLAQKTFVAAKQVLGWAVEELDQFVIHQVSRPHTAAFVKSFGIDPAKVMTIFGEHGNIGPASVPIVLSKLKELGRLKKGDRIALLGIGSGLNCSMAEVVW 5w3k A 1.59 BS01 9TY A 1 E230 I250 S251 A254 E229 I249 S250 A253 1.1.1.86 28975665 TTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQARNIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEGGMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKEFYKLREEQHGHQIEKVGRELREMMPFI 5w3k A 1.59 BS03 MG A 2 V70 K71 Q72 A73 N101 V69 K70 Q71 A72 N100 1.1.1.86 28975665 TTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQARNIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEGGMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKEFYKLREEQHGHQIEKVGRELREMMPFI 5w3k A 1.59 BS04 NDP A 1 Y25 G26 S27 Q28 I47 R48 S52 L79 L80 P81 D82 Q85 V88 A106 H107 P129 G131 P132 G133 Y24 G25 S26 Q27 I46 R47 S51 L78 L79 P80 D81 Q84 V87 A105 H106 P128 G130 P131 G132 1.1.1.86 28975665 TTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQARNIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEGGMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKEFYKLREEQHGHQIEKVGRELREMMPFI 5w3v A 2.24 BS01 NUC E 1 R17 R18 V19 Y23 Y24 P25 R26 K51 W82 L111 Y112 Y113 H114 W115 R17 R18 V19 Y23 Y24 P25 R26 K51 W82 L111 Y112 Y113 H114 W115 AALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLINKKEDHAEIRFINEIKSMGLDETQCYQVTCYLTWSPCPSCAGELVDFIKAHRHLNLRIFASRLYYHWHPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDHKEPPSFNPSEKLKELDKNSQAIKRRLERIKSRSVD 5w3v A 2.24 BS02 NUC F 1 R17 R18 N20 K21 Y23 H114 W115 Q120 R175 R176 R179 R183 R17 R18 N20 K21 Y23 H114 W115 Q120 R175 R176 R179 R183 AALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLINKKEDHAEIRFINEIKSMGLDETQCYQVTCYLTWSPCPSCAGELVDFIKAHRHLNLRIFASRLYYHWHPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDHKEPPSFNPSEKLKELDKNSQAIKRRLERIKSRSVD 5w3v A 2.24 BS03 ZN A 1 H54 C85 C88 H54 C85 C88 AALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLINKKEDHAEIRFINEIKSMGLDETQCYQVTCYLTWSPCPSCAGELVDFIKAHRHLNLRIFASRLYYHWHPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDHKEPPSFNPSEKLKELDKNSQAIKRRLERIKSRSVD 5w3v B 2.24 BS01 NUC E 1 R17 N20 K21 Y23 H114 W115 Q120 R175 R176 R16 N19 K20 Y22 H112 W113 Q118 R173 R174 ALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLINKKEDHAEIRFINEIKSMGLDETQYQVTCYLTWSPCPSCAGELVDFIKAHRHLNLRIFASRLYYHWHPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDHKEPPSFNPSEKLKELDKNSQAIKRRLERIKSR 5w3v B 2.24 BS02 NUC F 1 R18 V19 Y23 Y24 P25 R26 W82 L111 Y112 Y113 H114 W115 R17 V18 Y22 Y23 P24 R25 W80 L109 Y110 Y111 H112 W113 ALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLINKKEDHAEIRFINEIKSMGLDETQYQVTCYLTWSPCPSCAGELVDFIKAHRHLNLRIFASRLYYHWHPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDHKEPPSFNPSEKLKELDKNSQAIKRRLERIKSR 5w3v C 2.24 BS01 NUC G 1 K16 R17 N20 K21 Y23 H114 W115 Q120 R175 R176 R179 K15 R16 N19 K20 Y22 H112 W113 Q118 R173 R174 R177 ALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLINKKEDHAEIRFINEIKSMGLDETQYQVTCYLTWSPCPSCAGELVDFIKAHRHLNLRIFASRLYYHWHPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDHKEPPSFNPSEKLKELDKNSQAIKRRLERIKSRSV 5w3v D 2.24 BS02 NUC H 1 R17 R18 N20 K21 Y23 H114 W115 Q120 R175 R176 R16 R17 N19 K20 Y22 H112 W113 Q118 R173 R174 ALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLINKKEDHAEIRFINEIKSMGLDETQYQVTCYLTWSPCPSCAGELVDFIKAHRHLNLRIFASRLYYHWHPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDHKEPPSFNPSEKLKELDKNSQAIKRRLERIKSRS 5w5j A 2.85 BS01 9WS A 1 L24 V32 A45 V46 K47 L79 I93 T95 E96 Y97 M98 L153 L16 V24 A37 V38 K39 L51 I64 T66 E67 Y68 M69 L124 2.7.10.2 ALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHILHKARFSYILPILGICNEPFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5j B 2.85 BS01 9WS B 1 L24 V32 A45 V46 K47 L79 I93 T95 E96 Y97 M98 L153 A163 L15 V22 A35 V36 K37 L58 I72 T74 E75 Y76 M77 L130 A140 2.7.10.2 LPTIPYHKLADLRYLSRASGTVSSARHADWRVQVAVKHLHDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPHHDLKTQNILLDNEFHVKIADFTIIYMPPENYEIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKK 5w5o A 2.89 BS01 9XA A 1 L24 S25 V32 A45 K47 L79 T95 E96 Y97 M98 G101 E105 L153 D164 L20 S21 V28 A41 K43 L66 T82 E83 Y84 M85 G88 E92 L140 D151 2.7.11.1,2.7.10.2 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o B 2.89 BS01 9XA B 1 L24 S25 V32 A45 K47 L79 I93 T95 E96 Y97 M98 P99 G101 S102 E105 R109 L153 A163 D164 L20 S21 V28 A41 K43 L66 I80 T82 E83 Y84 M85 P86 G88 S89 E92 R96 L140 A150 D151 2.7.11.1,2.7.10.2 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o C 2.89 BS01 9XA C 1 L24 S25 V32 A45 K47 E96 Y97 M98 P99 G101 S102 L153 A163 D164 L20 S21 V28 A41 K43 E83 Y84 M85 P86 G88 S89 L140 A150 D151 2.7.11.1,2.7.10.2 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o D 2.89 BS01 9XA D 1 L24 S25 V32 A45 K47 L79 T95 E96 Y97 M98 G101 L153 A163 D164 L20 S21 V28 A41 K43 L66 T82 E83 Y84 M85 G88 L140 A150 D151 2.7.11.1,2.7.10.2 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o F 2.89 BS01 9XA F 1 L24 S25 V32 A45 K47 L79 T95 E96 Y97 M98 P99 E105 R109 L153 D164 L20 S21 V28 A41 K43 L66 T82 E83 Y84 M85 P86 E92 R96 L140 D151 2.7.11.1,2.7.10.2 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o J 2.89 BS01 9XA J 1 L24 S25 V32 A45 K47 L79 T95 E96 Y97 M98 P99 G101 E105 Q150 L153 A163 D164 L20 S21 V28 A41 K43 L66 T82 E83 Y84 M85 P86 G88 E92 Q137 L140 A150 D151 2.7.11.1,2.7.10.2 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o P 2.89 BS01 9XA P 1 R22 L24 S25 V32 A45 K47 L79 I93 T95 E96 M98 G101 S102 L153 A163 D164 R18 L20 S21 V28 A41 K43 L66 I80 T82 E83 M85 G88 S89 L140 A150 D151 2.7.11.1,2.7.10.2 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5wa0 A 2.10 BS01 MSS A 1 Y76 I77 Q78 N79 N80 L125 C127 S128 G186 E188 V201 H228 R233 G241 V242 N244 K246 Y247 Y267 Y42 I43 Q44 N45 N46 L91 C93 S94 G152 E154 V167 H194 R199 G207 V208 N210 K212 Y213 Y233 1.8.3.1 28986298 KPLPDYVAWKDADALIVHSDKTLETKRSEFGTSIITPEEKLYIQNNVNTPPESILADRDGWKVEISGVKEPRTLTVAELKTLGLVTAATVLQCSGNGRKYFKDQLTGDQKMSGTPWTVGAAGCVIWSGVPLKAVVDALGGPAEGARFITGTGGEELPAGLDPKLLVVERSVPISNLDNVILAWEMNGRPLSLAHGGPLRMVVPGYSGVNNIKYVKAVAMTEVETDAKIQKTSYRVHALGEKGSPDQPSVWEQPVKSWITTPHEAAKAGQVQIAGVAFGGMNACKSVEVSVDGGQTWQEAEFIGPDLGRFAWRVFALSADLARGTYTLVSRATDTEGNVQPEETEMNGAGYGHNGWRAPAVKLTVA 5wda A 5.00 BS01 CA A 1 L114 D117 V119 P120 E121 S122 N123 D124 D125 L114 D117 V119 P120 E121 S122 N123 D124 D125 28993624 FTLLEIMVVIVILGVLASLVVPNLMGNKEKADRQKVVSDLVALEGALDMYKLDNSRYPTTEQGLQALVSAPSAEPHARNYPEGGYIRRLPQDPWGSDYQLLSPGQCGQVDIFSLGPDGVPESNDDIGNCT 5wht A 1.93 BS02 GAL A 1 S35 D36 S12 D13 28993610 EWTGDNTNAYYSDEVISELHVGQIDTSPYFCIKTVKANGSGTPVVACAVSKQSIWAPSFKELLDQARYFYSTGQSVRIHVQKNIWTYPLFVNTFSANALVGLSSCSATQCFGPKL 5whu A 2.20 BS01 SIA A 1 T28 Y29 Q30 S31 R59 N65 T7 Y8 Q9 S10 R38 N44 28993610 NMADYNTYQSNVQINNLSYGVYRSGDKESQFFCVGLKRGSQVPNVHTICKIDVFGTHKQGFDNMLATARYYYATGEDVRIYYKENVWTDRNFTAAFSGNELIAITTCTSSDYCMGPTLPN 5whu A 2.20 BS02 GAL A 1 S31 N32 R59 S10 N11 R38 28993610 NMADYNTYQSNVQINNLSYGVYRSGDKESQFFCVGLKRGSQVPNVHTICKIDVFGTHKQGFDNMLATARYYYATGEDVRIYYKENVWTDRNFTAAFSGNELIAITTCTSSDYCMGPTLPN 5whu A 2.20 BS03 SIA A 2 S45 I72 F75 V107 W108 T109 D110 S24 I51 F54 V86 W87 T88 D89 28993610 NMADYNTYQSNVQINNLSYGVYRSGDKESQFFCVGLKRGSQVPNVHTICKIDVFGTHKQGFDNMLATARYYYATGEDVRIYYKENVWTDRNFTAAFSGNELIAITTCTSSDYCMGPTLPN 5whu C 2.20 BS01 SIA C 1 S45 G46 I72 F75 V107 W108 T109 D110 S24 G25 I51 F54 V86 W87 T88 D89 28993610 NMADYNTYQSNVQINNLSYGVYRSGDKESQFFCVGLKRGSQVPNVHTICKIDVFGTHKQGFDNMLATARYYYATGEDVRIYYKENVWTDRNFTAAFSGNELIAITTCTSSDYCMGPTL 5whu E 2.20 BS01 SIA E 1 Y29 Q30 S31 R59 N65 Y8 Q9 S10 R38 N44 28993610 NMADYNTYQSNVQINNLSYGVYRSGDKESQFFCVGLKRGSQVPNVHTICKIDVFGTHKQGFDNMLATARYYYATGEDVRIYYKENVWTDRNFTAAFSGNELIAITTCTSSDYCMGPTLP 5whu F 2.20 BS01 CA F 1 C128 T129 C107 T108 28993610 NMADYNTYQSNVQINNLSYGVYRSGDKESQFFCVGLKRGSQVPNVHTICKIDVFGTHKQGFDNMLATARYYYATGEDVRIYYKENVWTDRNFTAAFSGNELIAITTCTSSDYCMGPTL 5whu I 2.20 BS01 SIA I 1 T28 Y29 Q30 S31 R59 N65 Y103 T7 Y8 Q9 S10 R38 N44 Y82 28993610 NMADYNTYQSNVQINNLSYGVYRSGDKESQFFCVGLKRGSQVPNVHTICKIDVFGTHKQGFDNMLATARYYYATGEDVRIYYKENVWTDRNFTAAFSGNELIAITTCTSSDYCMGPTL 5whu I 2.20 BS02 GAL I 1 S31 N32 S10 N11 28993610 NMADYNTYQSNVQINNLSYGVYRSGDKESQFFCVGLKRGSQVPNVHTICKIDVFGTHKQGFDNMLATARYYYATGEDVRIYYKENVWTDRNFTAAFSGNELIAITTCTSSDYCMGPTL 5whu I 2.20 BS03 SIA I 2 S45 G46 I72 F75 G76 V107 W108 T109 D110 S24 G25 I51 F54 G55 V86 W87 T88 D89 28993610 NMADYNTYQSNVQINNLSYGVYRSGDKESQFFCVGLKRGSQVPNVHTICKIDVFGTHKQGFDNMLATARYYYATGEDVRIYYKENVWTDRNFTAAFSGNELIAITTCTSSDYCMGPTL 5wm1 A 1.85 BS01 NUC P 1 S329 I464 S465 E468 P551 G552 G554 H555 S556 T557 F691 S692 R693 S694 R696 S24 I159 S160 E163 P246 G247 G249 H250 S251 T252 F386 S387 R388 S389 R391 2.7.7.- RIVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDV 5wm1 A 1.85 BS02 NUC T 1 I307 Y319 F320 H322 S323 R324 L325 H326 S329 H393 G394 T395 K396 N397 S398 D399 S589 K590 E606 Q619 R620 K621 S622 L623 S624 I625 D626 I627 N628 W629 K681 Y682 G684 M685 G686 I2 Y14 F15 H17 S18 R19 L20 H21 S24 H88 G89 T90 K91 N92 S93 D94 S284 K285 E301 Q314 R315 K316 S317 L318 S319 I320 D321 I322 N323 W324 K376 Y377 G379 M380 G381 2.7.7.- RIVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDV 5wm1 A 1.85 BS03 MG P 1 D548 L550 V553 D243 L245 V248 2.7.7.- RIVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDV 5wm1 A 1.85 BS04 BAP T 1 H555 M685 H250 M380 2.7.7.- RIVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDV 5wm1 A 1.85 BS07 MG A 3 D362 K525 D57 K220 2.7.7.- RIVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDV 5wm8 A 1.92 BS01 NUC P 1 S329 I464 G552 G554 H555 S556 T557 Q663 S690 S692 R693 S694 R696 S23 I158 G246 G248 H249 S250 T251 Q357 S384 S386 R387 S388 R390 2.7.7.- IVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDV 5wm8 A 1.92 BS04 BAP T 1 D399 W417 H555 K681 M685 D93 W111 H249 K375 M379 2.7.7.- IVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDV 5wmb A 2.25 BS01 NUC P 1 S329 I464 S465 E468 P551 G552 G554 S556 T557 Q663 F691 S692 R693 S694 S24 I159 S160 E163 P246 G247 G249 S251 T252 Q358 F386 S387 R388 S389 2.7.7.- RIVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDV 5x23 A 2.00 BS01 HEM A 1 R97 I112 V113 W120 R124 L294 A297 G298 T301 T302 T305 Q356 L362 S365 H368 P427 F428 S429 R433 C435 V436 G437 A441 R70 I85 V86 W93 R97 L267 A270 G271 T274 T275 T278 Q329 L335 S338 H341 P400 F401 S402 R406 C408 V409 G410 A414 1.14.13.-,1.14.13.80,1.14.13.48,1.14.13.49,1.14.99.38 28972767 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFTSVPPFYQLCFIPI 5x23 A 2.00 BS02 LSN A 1 A106 R108 V113 L201 N204 L208 N236 V237 M240 V292 D293 G296 A297 L362 L366 A79 R81 V86 L174 N177 L181 N209 V210 M213 V265 D266 G269 A270 L335 L339 1.14.13.-,1.14.13.80,1.14.13.48,1.14.13.49,1.14.99.38 28972767 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFTSVPPFYQLCFIPI 5x23 A 2.00 BS03 LSN A 2 F226 P227 G228 T229 N231 K232 F199 P200 G201 T202 N204 K205 1.14.13.-,1.14.13.80,1.14.13.48,1.14.13.49,1.14.99.38 28972767 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFTSVPPFYQLCFIPI 5x23 A 2.00 BS04 LSN A 3 F69 F100 Q214 N218 P363 T364 S365 P367 F476 F42 F73 Q187 N191 P336 T337 S338 P340 F449 1.14.13.-,1.14.13.80,1.14.13.48,1.14.13.49,1.14.99.38 28972767 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFTSVPPFYQLCFIPI 5x24 A 2.48 BS01 HEM A 1 R97 I112 W120 R124 L294 A297 G298 T301 Q356 S365 H368 P427 F428 S429 R433 C435 V436 G437 A441 R70 I85 W93 R97 L267 A270 G271 T274 Q329 S338 H341 P400 F401 S402 R406 C408 V409 G410 A414 1.14.13.-,1.14.13.80,1.14.13.48,1.14.13.49,1.14.99.38 28972767 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYLDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPI 5x24 A 2.48 BS02 LSN A 1 A106 R108 F114 N204 L233 V237 M240 D293 G296 E300 T301 L366 A79 R81 F87 N177 L206 V210 M213 D266 G269 E273 T274 L339 1.14.13.-,1.14.13.80,1.14.13.48,1.14.13.49,1.14.99.38 28972767 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYLDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPI 5x9u A 4.00 BS01 ADP A 1 P37 D87 G88 T89 T90 T91 G389 G390 G391 M430 F461 M469 V474 D476 P29 D79 G80 T81 T82 T83 G381 G382 G383 M422 F453 M461 V466 D468 29018216 EIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERVAAILRDAAAMLEDKLQDPGFKLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASEAGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTII 5x9u B 4.00 BS01 ADP B 1 P37 D87 G88 T89 T90 T91 G389 G390 M430 M469 V474 D476 P29 D79 G80 T81 T82 T83 G381 G382 M422 M461 V466 D468 29018216 EIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERVAAILRDAAAMLEDKLQDPGFKLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASEAGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTII 5x9u C 4.00 BS01 ADP C 1 P37 D87 G88 T90 T91 I152 G389 G390 M430 V474 D476 P29 D79 G80 T82 T83 I144 G381 G382 M422 V466 D468 29018216 EIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERVAAILRDAAAMLEDKLQDPGFKLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASEAGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTII 5x9v A 3.00 BS01 ANP A 1 S34 L35 G36 P37 N55 D56 G57 D87 G88 T89 T90 T91 I152 R155 D373 G389 G390 M430 F461 M469 V474 D476 S25 L26 G27 P28 N46 D47 G48 D78 G79 T80 T81 T82 I143 R146 D364 G380 G381 M421 F452 M460 V465 D467 29018216 IEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERVAAILRDAAAMLEDKLQDPGFKLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASEAGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTII 5x9v B 3.00 BS01 ANP B 1 S34 L35 G36 P37 D56 G57 D87 G88 T89 T90 T91 I152 R155 G389 G390 M430 F461 V474 D476 S25 L26 G27 P28 D47 G48 D78 G79 T80 T81 T82 I143 R146 G380 G381 M421 F452 V465 D467 29018216 IEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERVAAILRDAAAMLEDKLQDPGFKLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASEAGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTII 5x9v C 3.00 BS02 MG C 1 D87 D373 D78 D364 29018216 IEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERVAAILRDAAAMLEDKLQDPGFKLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASEAGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTII 5xc3 A 1.50 BS01 GDP A 1 G15 V16 G17 K18 S19 S20 N119 K120 D122 I123 S150 S151 F152 G11 V12 G13 K14 S15 S16 N115 K116 D118 I119 S146 S147 F148 28779233 GYKIILIGSSGVGKSSIVHQFLFNRKISNVSPTIGAAFASKQVIAKNGKTLKLNIWDTAGQERFRSITKMYYTNSLGCLVVFDVTDRESFDDVYYWINDLRINCHTTYYILVVANKIDIDKNNWRVSENEIKKFCRDNDCDYVFASSFESDTVNNLFGKMIDKMSEIK 5xc5 A 1.40 BS01 GTP A 1 S14 G15 V16 G17 K18 S19 S20 V34 T37 G64 K120 D122 S150 S151 F152 S10 G11 V12 G13 K14 S15 S16 V30 T33 G60 K116 D118 S146 S147 F148 28779233 GYKIILIGSSGVGKSSIVHQFLFNRKISNVSPTIGAAFASKQVIAKNGKTLKLNIWDTAGLERFRSITKMYYTNSLGCLVVFDVTDRESFDDVYYWINDLRINCHTTYYILVVANKIDIDKNNWRVSENEIKKFCRDNDCDYVFASSFESDTVNNLFGKMIDKMSEI 5xc5 A 1.40 BS02 MG A 1 S19 T37 S15 T33 28779233 GYKIILIGSSGVGKSSIVHQFLFNRKISNVSPTIGAAFASKQVIAKNGKTLKLNIWDTAGLERFRSITKMYYTNSLGCLVVFDVTDRESFDDVYYWINDLRINCHTTYYILVVANKIDIDKNNWRVSENEIKKFCRDNDCDYVFASSFESDTVNNLFGKMIDKMSEI 5xo2 A 2.20 BS02 SIA X 1 Y33 W59 F76 R126 Q137 Q138 W139 Q140 I142 Y3 W29 F46 R96 Q107 Q108 W109 Q110 I112 MLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSIT 5xo2 B 2.20 BS01 III Y 1 M31 F76 H77 I142 M1 F46 H47 I112 MLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSIT 5xof A 1.96 BS01 III O 1 Y33 F76 H77 I142 Y3 F46 H47 I112 MLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSI 5xof C 1.96 BS02 SIA Q 1 Y33 W59 F76 R126 Q137 Q138 W139 Q140 Y3 W29 F46 R96 Q107 Q108 W109 Q110 MLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSIT 5xp3 D 2.30 BS01 GTP D 1 G10 Q11 C12 Q15 A97 G98 N99 S138 G141 G142 T143 G144 V175 S176 E181 N204 Y222 N226 G10 Q11 C12 Q15 A97 G98 N99 S138 G141 G142 T143 G144 V175 S176 E181 N204 Y222 N226 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLLTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 5xw6 C 3.10 BS01 128 C 1 T64 K66 T177 V178 F179 T202 I216 T38 K40 T151 V152 F153 T176 I190 29026074 SCVKWFIYGVIAVYICYTLIVHKRYQEKEELTSSVRVTLKGVAHVDRIWDAAEYTIPTQTRDSFFVMTNIIRTENQIQKTCPEYPTAKAICSSDKSCAKGIVDVHSNGVQTGKCVHYNITHKTCEIKAWCPVQGEERPPVPAVLRSSEDFTVFIKNNIHFPTFQYTVQNISPKLNTSCKFNKVTAPLCPIFRLGDILQEAKENFSEMAVKGGIIAIEIKWDCDLDSWSYYCSPEYSFRRLDDKTRTQYPGFSIRFARHYKLPDGTEQRTLFKAYGIRFDVLVFGMGGQFKLIELFTFIGSTIAYFGLAVTIIEMCFHLYN 5xw6 C 3.10 BS02 128 A 1 T112 A113 V130 H131 K236 Y274 K298 Y300 T86 A87 V104 H105 K210 Y248 K272 Y274 29026074 SCVKWFIYGVIAVYICYTLIVHKRYQEKEELTSSVRVTLKGVAHVDRIWDAAEYTIPTQTRDSFFVMTNIIRTENQIQKTCPEYPTAKAICSSDKSCAKGIVDVHSNGVQTGKCVHYNITHKTCEIKAWCPVQGEERPPVPAVLRSSEDFTVFIKNNIHFPTFQYTVQNISPKLNTSCKFNKVTAPLCPIFRLGDILQEAKENFSEMAVKGGIIAIEIKWDCDLDSWSYYCSPEYSFRRLDDKTRTQYPGFSIRFARHYKLPDGTEQRTLFKAYGIRFDVLVFGMGGQFKLIELFTFIGSTIAYFGLAVTIIEMCFHLYN 5xw6 A 3.10 BS01 128 A 1 T64 K66 T177 V178 F179 K181 T202 I216 T38 K40 T151 V152 F153 K155 T176 I190 29026074 SCVKWFIYGVIAVYICYTLIVHKRYQEKEELTSSVRVTLKGVAHVDRIWDAAEYTIPTQTRDSFFVMTNIIRTENQIQKTCPEYPTAKAICSSDKSCAKGIVDVHSNGVQTGKCVHYNITHKTCEIKAWCPVQGEERPPVPAVLRSSEDFTVFIKNNIHFPTFQYTVQNISPKLNTSCKFNKVTAPLCPIFRLGDILQEAKENFSEMAVKGGIIAIEIKWDCDLDSWSYYCSPEYSFRRLDDKTRTQYPGFSIRFARHYKLPDGTEQRTLFKAYGIRFDVLVFGMGGQFKLIELFTFIGSTIAYFGLAVTIIEMCFHLYN 5xw6 A 3.10 BS02 128 B 1 T112 H131 K236 Y274 K298 Y300 T86 H105 K210 Y248 K272 Y274 29026074 SCVKWFIYGVIAVYICYTLIVHKRYQEKEELTSSVRVTLKGVAHVDRIWDAAEYTIPTQTRDSFFVMTNIIRTENQIQKTCPEYPTAKAICSSDKSCAKGIVDVHSNGVQTGKCVHYNITHKTCEIKAWCPVQGEERPPVPAVLRSSEDFTVFIKNNIHFPTFQYTVQNISPKLNTSCKFNKVTAPLCPIFRLGDILQEAKENFSEMAVKGGIIAIEIKWDCDLDSWSYYCSPEYSFRRLDDKTRTQYPGFSIRFARHYKLPDGTEQRTLFKAYGIRFDVLVFGMGGQFKLIELFTFIGSTIAYFGLAVTIIEMCFHLYN 5xw6 B 3.10 BS02 128 B 1 T64 K66 T177 V178 F179 K181 T202 T38 K40 T151 V152 F153 K155 T176 29026074 SCVKWFIYGVIAVYICYTLIVHKRYQEKEELTSSVRVTLKGVAHVDRIWDAAEYTIPTQTRDSFFVMTNIIRTENQIQKTCPEYPTAKAICSSDKSCAKGIVDVHSNGVQTGKCVHYNITHKTCEIKAWCPVQGEERPPVPAVLRSSEDFTVFIKNNIHFPTFQYTVQNISPKLNTSCKFNKVTAPLCPIFRLGDILQEAKENFSEMAVKGGIIAIEIKWDCDLDSWSYYCSPEYSFRRLDDKTRTQYPGFSIRFARHYKLPDGTEQRTLFKAYGIRFDVLVFGMGGQFKLIELFTFIGSTIAYFGLAVTIIEMCFHLYN 5xxi A 2.30 BS02 LSN A 2 F226 P227 G228 T229 N231 K232 K235 F199 P200 G201 T202 N204 K205 K208 1.14.13.-,1.14.13.80,1.14.13.48,1.14.13.49,1.14.99.38 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPI 5xxi A 2.30 BS03 LSN A 3 F100 F114 Q214 I215 N218 L361 L362 P363 T364 S365 P367 F476 F73 F87 Q187 I188 N191 L334 L335 P336 T337 S338 P340 F449 1.14.13.-,1.14.13.80,1.14.13.48,1.14.13.49,1.14.99.38 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPI 5y9e A 2.04 BS01 MG A 1 Q305 F307 N308 R338 Q281 F283 N284 R314 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e A 2.04 BS02 MG A 2 G68 D335 T336 R338 S339 E367 G49 D311 T312 R314 S315 E343 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e A 2.04 BS03 MG A 3 R41 E368 R22 E344 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e A 2.04 BS04 MG A 4 E107 N308 K466 E88 N284 K409 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e A 2.04 BS05 MG A 5 L250 R251 L226 R227 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e B 2.04 BS01 MG A 6 D143 N144 R145 A264 D124 N125 R126 A238 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e B 2.04 BS02 MG B 1 Y242 D244 N320 W325 M393 Y216 D218 N294 W299 M367 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e B 2.04 BS03 MG B 2 S67 R72 E367 S48 R53 E341 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e B 2.04 BS04 MG B 3 H169 D209 H150 D183 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e B 2.04 BS05 MG B 4 Q156 T301 S304 Q305 T337 Q137 T275 S278 Q279 T311 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e B 2.04 BS07 MG B 6 P113 R338 T340 P94 R312 T314 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e C 2.04 BS01 MG C 1 G68 D335 R338 S339 E367 G49 D310 R313 S314 E342 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASTDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e C 2.04 BS02 MG C 2 Y231 R251 Y206 R226 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASTDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e C 2.04 BS03 MG C 3 W170 G206 C207 W151 G181 C182 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASTDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e C 2.04 BS05 MG C 5 N125 A264 G265 N106 A239 G240 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASTDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFEDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e D 2.04 BS01 MG C 6 N308 R338 N287 R317 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASNAAATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e D 2.04 BS02 MG C 7 Q112 M342 Q93 M321 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASNAAATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e D 2.04 BS04 MG C 9 Y354 N356 Y333 N335 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASNAAATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e D 2.04 BS07 MG D 3 E347 K350 E326 K329 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASNAAATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e E 2.04 BS02 MG E 1 D209 G211 D190 G192 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASNNNAAATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5y9e E 2.04 BS05 MG E 4 V100 W101 C324 N327 V81 W82 C305 N308 28951471 KVVSTDEYVSRTSIYYYAGSSRLLAVGNPYFSIKSPNNNKKVLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWACVGLEIGRGQPLGVGVSGHPYLNKFDDTETSNRYPAQPGSDNRECLSMDYKQTQLCLIGCKPPTGEHWGKGVASNNNAAATDCPPLELFNSIIEDGDMVDTGFGCMDFGTLQANKSDVPIDICNSTCKYPDYLKMASEPYGDSLFFFLRREQMFVRHFFNRAGKLGEAVPDDLYIKGSGNTAVIQSSAFFPTPSGSIVTSESQLFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMTLCTEVTKEGTYKNDNFKEYVRHVEEYDLQFVFQLCKITLTAEIMTYIHTMDSNILEDWQFDPLNKYTFWEVNLKEKFSADLDQFPLGRKFLLQSGL 5ykb D 2.76 BS01 CA D 1 N105 W170 D179 L180 Y213 L214 E216 N100 W141 D150 L151 Y184 L185 E187 5.4.99.16 PEWYKSAVFYELSVRTFQDGNGDGKGDFPGLTSRLDYLKNLGVDCLWLLPWFPSPLRDDGYDVADYRGIHPDLGTLDDFKVFLREAHARGLWVIGDLVTNHTSSDHPWFQAARRGPTLNEYHDYYVWSNWTLDEQAGKYYWHRFFASQPDLNYDNPKVVEELHGAARFWLDLGLDGFRVDAVPYLIEREGTSCENLPETHEILKGFRAMVDREYPGRLLLAEAFQWPEEVVEYFGTEAEPEFHMCFNFPVMPRLYMSLKREDTSSIREIMGRLPKIPSFGQWCIFLRNHDELTLEMVTDDERAFMYAAYAPDARMKINVGIRRRLAPLLDNDRRRIELLNTVLLALPGSPVLYYGDEIGMGDDLGLPDRNGVRTPMQWNAGTSGGFSTAQPSDCFFPPIQDPVYGFGRVNVQSQLQDPSSLLKWTARQLELRRAHPAFAHGDLTFIETGNPAILAFTRQYDGETLLIVSNFAGNAQAGLLDLAPFVGRAPVTLSGASPLPVVTGNGQYPVVMGKYDYYWLRLN 6anv A 2.27 BS01 MTT A 1 D94 K95 E124 E125 W142 A143 D145 R146 E191 E233 P234 Y235 F236 W310 W420 Y421 R424 D95 K96 E125 E126 W143 A144 D146 R147 E192 E234 P235 Y236 F237 W311 W421 Y422 R425 28985564 SMKFIKYLSTAHLNYMNIAVYENGSKIKARVENVVNGKSVGARDFDSTEQLESWFYGLPGSGLGRIENAMNEISRRENPLEKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAA 6anv B 2.27 BS01 MTT B 1 D94 K95 K122 E124 E125 W142 A143 D145 R146 E191 E233 P234 Y235 W310 M410 W420 Y421 R424 D95 K96 K123 E125 E126 W143 A144 D146 R147 E192 E234 P235 Y236 W311 M411 W421 Y422 R425 28985564 SMKFIKYLSTAHLNYMNIAVYENGSKIKARVENVVNGKSVGARDFDSTEQLESWFYGLPGSGLGRIENAMNEISRRENPLEKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAA 6awn A 3.62 BS02 8PR A 1 Y95 A96 D98 A169 I172 Y176 F335 S336 G338 F341 S438 T439 G442 V501 Y22 A23 D25 A96 I99 Y103 F262 S263 G265 F268 S365 T366 G369 V428 GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 6awo A 3.53 BS01 SRE A 1 Y95 D98 A169 I172 F335 G338 F341 S438 G442 Y22 D25 A96 I99 F262 G265 F268 S365 G369 GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 6awp A 3.80 BS01 FVX A 1 Y95 A96 D98 I172 F335 S336 F341 S438 S439 G442 T497 Y22 A23 D25 I99 F262 S263 F268 S365 S366 G369 T424 GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 6awq A 4.05 BS03 CL A 1 N101 F105 Y121 S336 S372 N28 F32 Y48 S263 S299 GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 6b0b A 3.28 BS01 NUC B 1 K16 R17 R18 R21 Y23 W115 R171 R175 R176 R179 K14 R15 R16 R19 Y21 W113 R169 R173 R174 R177 LLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKECHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLRIFASRLYYHWCKPQQDGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLDRIKQ 6b0b A 3.28 BS02 NUC C 1 Y24 R26 W82 R110 Y113 W115 Y22 R24 W80 R108 Y111 W113 LLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKECHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLRIFASRLYYHWCKPQQDGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLDRIKQ 6b0b A 3.28 BS03 ZN A 1 H54 C85 C88 H52 C83 C86 LLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKECHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLRIFASRLYYHWCKPQQDGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLDRIKQ 6b0b E 3.28 BS01 NUC F 1 K16 R17 R18 Y23 W115 K168 R171 R175 R176 R179 K14 R15 R16 Y21 W113 K166 R169 R173 R174 R177 LLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKECHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLRIFASRLYYHWCKPQQDGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLDRIKQ 6b16 A 2.29 BS01 C7Y A 1 V284 A297 E345 Y346 L347 D393 N394 L396 T406 V34 A47 E88 Y89 L90 D136 N137 L139 T149 2.7.11.1 27346791 EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQQPKKELIINEILVMRENKNPNIVNYLDSYLDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 6b16 B 2.29 BS01 C7Y B 1 A297 E345 Y346 L347 G350 D393 N394 L396 T406 D407 A43 E91 Y92 L93 G96 D139 N140 L142 T152 D153 2.7.11.1 27346791 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 6b27 A 1.73 BS01 III G 1 Y301 Q306 E307 D310 N326 D328 W329 F340 P342 N344 F345 Y8 Q13 E14 D17 N33 D35 W36 F47 P49 N51 F52 ANSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI 6b27 C 1.73 BS01 III I 1 Y301 F303 Q306 D310 N326 D328 W329 F340 P342 N344 F345 Y8 F10 Q13 D17 N33 D35 W36 F47 P49 N51 F52 ANSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRGFIRVSSGKKRGLVPVDALTEI 6b4w A 2.90 BS01 CQ7 A 1 I531 Q541 A551 K553 M602 E603 C604 G605 N606 I607 D608 S611 L654 I663 I17 Q27 A37 K39 M88 E89 C90 G91 N92 I93 D94 S97 L140 I149 2.7.12.1 28991472 NECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDVGTVNYMPPEAIKDMKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQI 6b8w B 1.90 BS01 MN B 1 H115 E121 H155 Y157 H35 E41 H75 Y77 QAMVVKPLFPWDETLKFDHFSIILAPGALSESTPHEAGVIEHVVVISGELEMKIDGEWRTLYPDQGVRFAGDKPHAYRNSSSRPVHFHSLIHYPR 6b9u A 1.80 BS01 NAI A 1 G13 S16 G17 F18 D37 R38 A59 D60 I61 N87 A88 G89 I90 V111 V142 A143 S144 Y157 K161 A189 G190 T192 P193 L194 F198 G11 S14 G15 F16 D35 R36 A57 D58 I59 N85 A86 G87 I88 V109 V140 A141 S142 Y155 K159 A187 G188 T190 P191 L192 F196 SLEGKVALITGAGSGFGEGMAKRFAKGGAKVVIVDRDKAGAERVAGEIGDAALAVAADISKEADVDAAVEAALSKFGKVDILVNNAGIGHKPQNAELVEPEEFDRIVGVNVRGVYLMTRKLIPHFKENGAKGQECVILNVASTGAGRPRPNLAWYNATKGWVVSVTKALAIELAPAKIRVVALNPVAGETPLLTTFMRKKFRDSIPMGRLLKPDDLAEAAAFLCSPQASMITGVALDVDGGRSI 6bal A 2.10 BS01 LMR A 1 R81 R87 N119 L149 R153 H177 S222 A223 R82 R88 N120 L150 R154 H178 S223 A224 1.1.1.37 AMKVAVLGAAGGIGQALALLLKLQLPAGTDLSLYDIAPVTPGVAVDVSHIPTAVNVKGFSGEDPTPALEGADVVLISAGVARKPGMDRSDLFNINAGIVRGLIEKVAVTCPKACVGIITNPVNTTVAIAAEVLKKAGVYDKRKLFGVTTLDVLRSETFVAELKGLNVSRTSVPVIGGHSGVTILPLLSQVQYAKWNEDEIEPLTKRIQNAGTEVLNAKAGGGSATLSMAQAAARFARSLVKGLSGETVVECTYVEGDGKYARFFSQPVRLGKEGVEEILPIGPLSNFEQQALENMLPTLRADIELGEKFING