4z2c A 3.19 BS01 NUC E 1 R30 K40 H43 H76 H78 G79 S82 R89 T170 I172 M264 R29 K39 H42 H75 H77 G78 S81 R88 T169 I171 M263 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2c A 3.19 BS02 NUC F 1 A117 I172 G175 M176 A177 N326 A116 I171 G174 M175 A176 N325 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2c C 3.19 BS01 NUC F 1 G434 D435 G34 D35 5.99.1.3 KHMKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVY 4z2c C 3.19 BS02 NUC H 1 I459 L460 N461 N473 H513 V630 R633 I59 L60 N61 N73 H113 V185 R188 5.99.1.3 KHMKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVY 4z2c C 3.19 BS03 NUC G 1 G457 K458 D510 I514 G57 K58 D110 I114 5.99.1.3 KHMKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVY 4z2c C 3.19 BS04 MFX F 1 R456 G457 E475 R56 G57 E75 5.99.1.3 KHMKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVY 4z2c B 3.19 BS01 NUC H 1 A117 I172 A173 G175 M176 A177 A116 I171 A172 G174 M175 A176 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVFVIEVKRDSANVILNNLFKMTMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2c B 3.19 BS02 NUC G 1 R30 K40 H43 H76 H78 S82 R89 T170 I172 R29 K39 H42 H75 H77 S81 R88 T169 I171 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVFVIEVKRDSANVILNNLFKMTMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2c D 3.19 BS01 NUC E 1 E433 G457 K458 S466 D510 I514 E28 G52 K53 S61 D105 I109 5.99.1.3 MKSGLEIPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYS 4z2c D 3.19 BS02 NUC F 1 K458 I459 L460 N461 N473 H513 V630 R633 K53 I54 L55 N56 N68 H108 V180 R183 5.99.1.3 MKSGLEIPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYS 4z2d A 3.38 BS01 NUC E 1 R30 H43 H76 H78 S82 T170 I172 R29 H42 H75 H77 S81 T169 I171 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2d A 3.38 BS02 NUC F 1 A117 R119 I172 A173 V174 G175 M176 A177 A116 R118 I171 A172 V173 G174 M175 A176 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2d C 3.38 BS01 NUC F 1 G434 D435 S436 G34 D35 S36 5.99.1.3 KHMKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVY 4z2d C 3.38 BS02 NUC H 1 K458 L460 N461 N473 H513 V630 R633 K58 L60 N61 N73 H113 V185 R188 5.99.1.3 KHMKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVY 4z2d C 3.38 BS03 NUC G 1 G457 K458 D510 G57 K58 D110 5.99.1.3 KHMKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVY 4z2d B 3.38 BS01 NUC H 1 A117 I172 A173 V174 G175 M176 A177 A116 I171 A172 V173 G174 M175 A176 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVFVIRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2d D 3.38 BS01 NUC E 1 E433 G457 K458 D510 I514 E28 G52 K53 D105 I109 5.99.1.3 MKSGLEIPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYS 4z2d D 3.38 BS02 NUC F 1 K458 I459 L460 N461 H513 V630 R633 K53 I54 L55 N56 H108 V180 R183 5.99.1.3 MKSGLEIPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYS 4z2e A 3.46 BS01 NUC E 1 R30 V42 H43 H76 H78 R89 T170 I172 R29 V41 H42 H75 H77 R88 T169 I171 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2e A 3.46 BS02 NUC F 1 A117 R119 I172 A173 V174 G175 M176 A177 N326 A116 R118 I171 A172 V173 G174 M175 A176 N325 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2e C 3.46 BS03 TR6 F 1 G434 R456 E475 G34 R56 E75 5.99.1.3 KHMKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVY 4z2e B 3.46 BS01 NUC H 1 A117 A173 V174 G175 A177 A116 A172 V173 G174 A176 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2e B 3.46 BS02 NUC G 1 V42 H43 H76 H78 T170 V41 H42 H75 H77 T169 5.99.1.3 QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV 4z2e D 3.46 BS04 TR6 H 1 R456 G457 R51 G52 5.99.1.3 MKSGLEIPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYS 4z3o A 3.44 BS01 NUC F 1 G434 D435 S436 G20 D21 S22 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z3o A 3.44 BS02 NUC G 1 E433 G457 K458 D510 R1028 K1038 V1040 H1074 H1076 G1077 S1080 A1084 R1087 T1168 I1170 E19 G43 K44 D96 R233 K243 V245 H279 H281 G282 S285 A289 R292 T373 I375 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z3o A 3.44 BS03 NUC H 1 K458 I460 N461 K464 N473 H513 V626 R629 R630 R1117 Y1118 I1170 S1171 A1172 G1173 Y1174 A1175 R1235 N1326 K44 I46 N47 K50 N59 H99 V193 R196 R197 R322 Y323 I375 S376 A377 G378 Y379 A380 R440 N531 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z3o A 3.44 BS04 MG A 1 D506 D508 D92 D94 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z3o A 3.44 BS05 MFX H 1 R456 S1079 R42 S284 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z3o B 3.44 BS01 NUC E 1 E433 G457 K458 D510 R1028 K1038 V1040 H1074 H1076 S1080 R1087 K1093 T1168 I1170 E19 G43 K44 D96 R233 K243 V245 H279 H281 S285 R292 K298 T373 I375 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMAYAWTDGELEELRKQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z3o B 3.44 BS02 NUC F 1 K458 V459 I460 N461 K464 N473 H513 V626 R629 R1117 Y1118 I1170 S1171 A1172 G1173 Y1174 A1175 N1326 K44 V45 I46 N47 K50 N59 H99 V194 R197 R322 Y323 I375 S376 A377 G378 Y379 A380 N531 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMAYAWTDGELEELRKQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z3o B 3.44 BS05 MFX F 1 R456 G457 E475 S1079 R42 G43 E61 S284 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMAYAWTDGELEELRKQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z4q A 3.04 BS04 MG A 1 F1316 K1317 T1319 Q1322 F522 K523 T525 Q528 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKAYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z4q A 3.04 BS06 PDQ F 1 R456 E475 S1079 R42 E61 S285 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKAYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z4q B 3.04 BS02 NUC G 1 E433 G457 K458 D510 R1028 K1038 H1074 H1076 G1077 S1080 R1087 K1093 T1168 I1170 E19 G43 K44 D96 R252 K262 H298 H300 G301 S304 R311 K317 T392 I394 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z4q B 3.04 BS03 NUC H 1 K458 V459 I460 N461 K464 N473 H513 V626 R629 Y1118 I1170 S1171 A1172 G1173 Y1174 A1175 K1233 R1235 N1328 K44 V45 I46 N47 K50 N59 H99 V212 R215 Y342 I394 S395 A396 G397 Y398 A399 K457 R459 N552 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z4q B 3.04 BS04 MG B 1 F1316 T1319 Q1322 F540 T543 Q546 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z4q B 3.04 BS05 MG B 2 E433 D506 D508 E19 D92 D94 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z4q B 3.04 BS06 PDQ H 1 R456 G457 E474 E475 S1079 R42 G43 E60 E61 S303 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z53 A 3.26 BS02 NUC F 1 K458 V459 I460 N461 K464 N473 H513 V626 R629 R630 R1117 Y1118 I1170 S1171 A1172 G1173 Y1174 A1175 R1235 N1326 K44 V45 I46 N47 K50 N59 H99 V194 R197 R198 R323 Y324 I376 S377 A378 G379 Y380 A381 R441 N532 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKAYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4z53 B 3.26 BS05 TR6 H 1 G434 R456 G457 E475 S1079 G20 R42 G43 E61 S290 5.99.1.3,5.99.1.3 KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMAYAWTDGELEELRKQLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEENIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4zcp A 1.98 BS01 C5P A 1 G624 V625 Y626 H630 G632 H633 Q636 D710 Q754 R755 T756 G9 V10 Y11 H15 G17 H18 Q21 D95 Q113 R114 T115 2.7.7.15 KNVVIYADGVYDMLHLGHMKQLEQAKKLFENTTLIVGVTSDNETKLFKGQVVQTLEERTETLKHIRWVDEIISPCPWVVTPEFLEKYKIDYVAHDDIDIYAWLKRAGKFKATQRTEGVSTTDLIVRILK 4zcq A 1.92 BS01 CHT A 1 D623 G624 T654 W692 H709 Y741 D8 G9 T39 W77 H94 Y99 2.7.7.15 KNVVIYADGVYDMLHLGHMKQLEQAKKLFENTTLIVGVTSDNETKLFKGQVVQTLEERTETLKHIRWVDEIISPCPWVVTPEFLEKYKIDYVAHDEDIYAWLKRAGKFKATQRTEGVSTTDLIVRILKNY 4zcr A 1.80 BS01 PC A 1 D623 G624 V625 T654 K663 W692 H709 Y741 D8 G9 V10 T39 K48 W77 H94 Y99 2.7.7.15 KNVVIYADGVYDMLHLGHMKQLEQAKKLFENTTLIVGVTSDNETKLFKGQVVQTLEERTETLKHIRWVDEIISPCPWVVTPEFLEKYKIDYVAHDDDIYAWLKRAGKFKATQRTEGVSTTDLIVRILK 4zog A 2.30 BS01 VX6 A 1 L248 Y253 V256 A269 K271 I313 T315 E316 F317 M318 T319 Y320 G321 L370 F382 L16 Y21 V24 A37 K39 I81 T83 E84 F85 M86 T87 Y88 G89 L138 F150 2.7.10.2 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS 4zog A 2.30 BS02 MXE A 1 D363 N368 G383 D131 N136 G151 2.7.10.2 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS 4zog A 2.30 BS03 MXE A 2 F401 P402 I403 K404 L445 F169 P170 I171 K172 L213 2.7.10.2 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS 4zog B 2.30 BS01 VX6 B 1 L248 G249 Y253 V256 A269 K271 M290 T315 E316 F317 M318 T319 Y320 G321 L370 L15 G16 Y20 V23 A36 K38 M57 T82 E83 F84 M85 T86 Y87 G88 L137 2.7.10.2 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSIS 5arb A 1.15 BS02 EI3 A 1 Y209 A215 S216 C217 Y203 A209 S210 C211 3.4.21.62 AQSVPWGISRVQAPAAHNRGLTGSGVKVAVLDTGISTHPDLNIRGGASFVPGEPSTQDGNGHGTHVAGTIAALNNSIGVLGVAPSAELYAVKVLGASGSGSVSSIAQGLEWAGNNGMHVANLSLGSPSPSATLEQAVNSATSRGVLVVAASGNSGAGSISYPARYANAMAVGATDQNNNRASFSQYGAGLDIVAPGVNVQSTYPGSTYASCNGTSMATPHVAGAAALVKQKNPSWSNVQIRNHLKNTATSLGSTNLYGSGLVNAEAATR 5arc A 1.10 BS02 EI3 A 1 H64 H67 C217 M222 H62 H65 C211 M216 3.4.21.62 AQSVPWGISRVQAPAAHNRGLTGSGVKVAVLDTGISTHPDLNIRGGASFVPGEPSTQDGNGHGTHVAGTIAALNNSIGVLGVAPSAELYAVKVLGASGSGSVSSIAQGLEWAGNNGMHVANLSLGSPSPSATLEQAVNSATSRGVLVVAASGNSGAGSISYPARYANAMAVGATDQNNNRASFSQYGAGLDIVAPGVNVQSTYPGSTYASCNGTSMATPHVAGAAALVKQKNPSWSNVQIRNHLKNTATSLGSTNLYGSGLVNAEAATR 5b1a A 1.50 BS01 HEA A 1 A24 G27 M28 T31 S34 I37 R38 Y54 V58 H61 A62 M65 I66 V70 I73 G125 W126 Y371 V374 F377 H378 L381 S382 V386 M390 F393 M417 T424 F425 Q428 R438 R439 S458 V465 M468 A24 G27 M28 T31 S34 I37 R38 Y54 V58 H61 A62 M65 I66 V70 I73 G125 W126 Y371 V374 F377 H378 L381 S382 V386 M390 F393 M417 T424 F425 Q428 R438 R439 S458 V465 M468 1.9.3.1 MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTISSMGSFISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK 5b1a C 1.50 BS01 DMU J 1 L25 S29 M33 F37 L23 S27 M31 F35 HQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMIGLTTNMLTMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQALFITITLGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS 5b1a J 1.50 BS01 DMU J 1 S46 Y48 C49 L50 W52 A53 S46 Y48 C49 L50 W52 A53 FENRVAEKQKLFQEDNGLPVHLKGGATDNILYRVTMTLCLGGTLYSLYCLGWASFPHK 5b1a N 1.50 BS01 HEA N 1 A24 G27 M28 T31 S34 I37 R38 Y54 V58 H61 A62 M65 I66 V70 G125 W126 Y371 V374 F377 H378 L381 S382 V386 F393 T424 F425 Q428 R438 R439 S458 V465 M468 A24 G27 M28 T31 S34 I37 R38 Y54 V58 H61 A62 M65 I66 V70 G125 W126 Y371 V374 F377 H378 L381 S382 V386 F393 T424 F425 Q428 R438 R439 S458 V465 M468 1.9.3.1 MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTISSMGSFISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK 5b1a P 1.50 BS01 DMU P 1 S29 M33 F37 S27 M31 F35 HQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMIGLTTNMLTMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQALFITITLGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS 5b1a W 1.50 BS01 DMU P 1 S46 Y48 C49 W52 S46 Y48 C49 W52 FENRVAEKQKLFQEDNGLPVHLKGGATDNILYRVTMTLCLGGTLYSLYCLGWASFPHK 5b1b C 1.60 BS01 DMU C 1 S29 T32 M33 F37 S27 T30 M31 F35 HQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMIGLTTNMLTMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQALFITITLGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS 5b1b N 1.60 BS01 HEA N 1 A24 G27 T31 S34 I37 R38 Y54 V58 H61 A62 M65 I66 V70 I73 G125 W126 Y371 F377 H378 L381 S382 V386 M390 F393 F425 Q428 R438 R439 S461 V465 A24 G27 T31 S34 I37 R38 Y54 V58 H61 A62 M65 I66 V70 I73 G125 W126 Y371 F377 H378 L381 S382 V386 M390 F393 F425 Q428 R438 R439 S461 V465 1.9.3.1 MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTISSMGSFISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK 5b1b W 1.60 BS01 DMU P 1 Y48 C49 W52 Y48 C49 W52 FENRVAEKQKLFQEDNGLPVHLKGGATDNILYRVTMTLCLGGTLYSLYCLGWASFPHK 5b59 A 2.00 BS01 KTO A 1 N59 S60 R61 W63 R73 N74 L75 D101 N59 S60 R61 W62 R72 N73 L74 D100 3.2.1.17 27534812 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 5bn8 A 1.34 BS01 MG A 1 T13 G201 G202 G203 T204 T10 G198 G199 G200 T201 AAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMG 5bn9 A 1.69 BS01 ADP A 1 G12 T13 T14 Y15 G201 G202 G230 E231 D234 E268 K271 K272 S275 G338 G339 S340 R342 I343 D366 G9 T10 T11 Y12 G198 G199 G227 E228 D231 E265 K268 K269 S272 G335 G336 S337 R339 I340 D363 AAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKKTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMG 5bpm A 1.83 BS01 ATP A 1 G12 T13 T14 Y15 G201 G202 G203 T204 G230 E231 D234 K271 K272 S275 G338 G339 S340 R342 I343 D366 G9 T10 T11 Y12 G198 G199 G200 T201 G227 E228 D231 K268 K269 S272 G335 G336 S337 R339 I340 D363 AAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACQRAKKTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILM 5br5 A 2.00 BS01 RET A 1 W86 T90 M118 W138 S141 T142 W182 Y185 P186 W189 D212 K216 W80 T84 M112 W132 S135 T136 W171 Y174 P175 W178 D201 K205 TGRPEWIWLALGTALMGLGTLYFLVKGMGVSDPDAKKFYAITTLVPAIAFTMYLSMLLGYGLTMVPFGQNPIYWARYADWLFTTPLLLLDLALLVDADQGTILALVGADGIMIGTGLVGALTKVYSYRFVWWAISTAAMLYILYVLFFGFSMRPEVASTFKVLRNVTVVLWSAYPVVWLIGSEGAGIVPLNIETLLFMVLDVSAKVGFGLILLRSRAIFGEE 5bx6 A 1.89 BS01 III B 1 L82 E127 F129 S130 R133 K168 P169 E170 F187 L198 C199 G200 T201 P202 E203 E230 G234 Y235 P236 F239 A240 D241 I246 D328 Y330 L78 E123 F125 S126 R129 K164 P165 E166 F183 L194 C195 G196 T197 P198 E199 E226 G230 Y231 P232 F235 A236 D237 I242 D324 Y326 2.7.11.11 AAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 5bx6 A 1.89 BS02 495 A 1 L49 V57 A70 V104 M120 E121 Y122 V123 L173 T183 F327 L45 V53 A66 V100 M116 E117 Y118 V119 L169 T179 F323 2.7.11.11 AAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 5bx7 A 1.89 BS01 III B 1 L82 K83 Q84 E127 F129 S130 R133 K168 P169 E170 F187 L198 C199 G200 T201 P202 E203 E230 G234 Y235 P236 F239 A240 D241 I246 D328 Y330 L78 K79 Q80 E123 F125 S126 R129 K164 P165 E166 F183 L194 C195 G196 T197 P198 E199 E226 G230 Y231 P232 F235 A236 D237 I242 D324 Y326 2.7.11.11 AAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 5bx7 A 1.89 BS02 4W1 A 1 V57 A70 M120 E121 Y122 V123 E127 L173 T183 F327 V53 A66 M116 E117 Y118 V119 E123 L169 T179 F323 2.7.11.11 AAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 5cde A 1.85 BS01 ZN A 1 D251 D262 E374 D250 D261 E373 STQIGGMSLDQARTQLAPWTQRAAPIGADEYQQRIERARVLMRAQGVDALLIGAGTSLRYFSGVPWGASERLVALLLTTEGDPVLICPAFEEGSLDAVLQLPVRKRLWEEHEDPYALVVQAMDEQHAHALALDPGIAFAVHTGLRAHLGTAIRDAGAIIDGCRMCKSPAELALMQQACDMTLLVQRLAAGIAHEGIGTDQLVRFIDEAHRALGADNGSTFCIVQFGHATAFPHGIPGVQHLRAGELVLIDTGCTVQGYHSDITRTWIYGTPSDAQQRIWELELAAQAAAFAAVRPGVACEAVDQAARAVLQAAGLGPDYRLPGLPHRTGHGCGLAIHEAPYLVRGNRQPLQPGMCASNEPMIVVPGAFGVALEDHFYVTDTGAQWFTPPSVAIDQPFA 5cde A 1.85 BS02 ZN A 2 D262 H331 E360 E374 D261 H330 E359 E373 STQIGGMSLDQARTQLAPWTQRAAPIGADEYQQRIERARVLMRAQGVDALLIGAGTSLRYFSGVPWGASERLVALLLTTEGDPVLICPAFEEGSLDAVLQLPVRKRLWEEHEDPYALVVQAMDEQHAHALALDPGIAFAVHTGLRAHLGTAIRDAGAIIDGCRMCKSPAELALMQQACDMTLLVQRLAAGIAHEGIGTDQLVRFIDEAHRALGADNGSTFCIVQFGHATAFPHGIPGVQHLRAGELVLIDTGCTVQGYHSDITRTWIYGTPSDAQQRIWELELAAQAAAFAAVRPGVACEAVDQAARAVLQAAGLGPDYRLPGLPHRTGHGCGLAIHEAPYLVRGNRQPLQPGMCASNEPMIVVPGAFGVALEDHFYVTDTGAQWFTPPSVAIDQPFA 5cde B 1.85 BS03 ZN B 3 S70 E71 S68 E69 TQIGGMSLDQARTQLAPWTQRAAPIGADEYQQRIERARVLMRAQGVDALLIGAGTSLRYFSGVPWGASERLVALLLTTEGDPVLICPAFEEGSLDAVLQLPVRKRLWEEHEDPYALVVQAMDEQHAHALALDPGIAFAVHTGLRAHLGTAIRDAGAIIDGCRMCKSPAELALMQQACDMTLLVQRLAAGIAHEGIGTDQLVRFIDEAHRALGADNGSTFCIVQFGHATAFPHGIPGVQHLRAGELVLIDTGCTVQGYHSDITRTWIYGTPSDAQQRIWELELAAQAAAFAAVRPGVACEAVDQAARAVLQAAGLGPDYRLPGLPHRTGHGCGLAIHEAPYLVRGNRQPLQPGMCASNEPMIVVPGAFGVALEDHFYVTDTGAQWFTPPSVAIDQPFA 5cm0 A 1.90 BS01 PLP A 1 H50 R53 R141 K152 Y156 N159 E185 S187 G188 D189 N190 L208 I211 T212 G247 T248 H48 R51 R131 K142 Y146 N149 E175 S177 G178 D179 N180 L198 I201 T202 G237 T238 ELLVYMNGEFVPESQAKVSVFDHGFLYGDGVFEGIRAYNGKVFKLYEHIDRLYDCARVIDLKIPLSKEEFAEAILETLRRNNLRDAYIRPIVTRGAGDLGLDPRKCPSPNVIIITKPWEKGLKAITVAIRRNAIDSLPPNIKSLNYLNNILAKIEANAKGGDEAIFLDHNGYISEGSGDNIFIVKNGTITTPPTLNNLKGITRQVVIELINELEIPFREANIGLFDLYSADEIFVTGTAAEIAPVTYIDGRTVGNGKPGKVTKMLMEKFRERTENEGVEIYR 5cm0 B 1.90 BS01 PLP B 1 H50 R53 R141 K152 Y156 N159 E185 S187 G188 D189 L208 G210 I211 T212 G247 T248 H48 R51 R137 K148 Y152 N155 E181 S183 G184 D185 L204 G206 I207 T208 G243 T244 ELLVYMNGEFVPESQAKVSVFDHGFLYGDGVFEGIRAYNGKVFKLYEHIDRLYDCARVIDLKIPLSKEEFAEAILETLRRNNLRDAYIRPIVTRGAGDLGLDPRKCPSPNVIIITKPKLYGDLYEKGLKAITVAIRRNAIDSLPPNIKSLNYLNNILAKIEANAKGGDEAIFLDHNGYISEGSGDNIFIVKNGTITTPPTLNNLKGITRQVVIELINELEIPFREANIGLFDLYSADEIFVTGTAAEIAPVTYIDGRTVGNGKPGKVTKMLMEKFRERTENEGVEIY 5cyb A 2.10 BS01 CA A 1 D80 D81 S145 D146 D17 D18 S82 D83 QPVAQPTDIDGTYTGQDDGDRITLVVTGTTGTWTELESDGDQKVKQVTLDSANQRMIIGDDVKIYTVNGNQIVVDDMDRDPSDQIVLTK 5cyb A 2.10 BS02 CA A 2 D102 D104 D39 D41 QPVAQPTDIDGTYTGQDDGDRITLVVTGTTGTWTELESDGDQKVKQVTLDSANQRMIIGDDVKIYTVNGNQIVVDDMDRDPSDQIVLTK 5cyb A 2.10 BS03 CA A 3 D139 D141 D143 D146 D76 D78 D80 D83 QPVAQPTDIDGTYTGQDDGDRITLVVTGTTGTWTELESDGDQKVKQVTLDSANQRMIIGDDVKIYTVNGNQIVVDDMDRDPSDQIVLTK 5d6g A 3.30 BS01 NUC 0 1 A10 K13 V17 M36 D37 P39 A40 P41 Q44 R47 R51 R57 M58 R60 N61 T62 L63 R66 R89 R117 A1 K4 V8 M27 D28 P30 A31 P32 Q35 R38 R42 R48 M49 R51 N52 T53 L54 R57 R80 R108 APWKIEEVKTLKGLIKSKPVVAIVDMMDVPAPQLQEIRDKIRDKVKLRMSRNTLIIRALKEAAEELNNPKLAELANYVERGAAILVTDMNPFKLYKLLEENKSPAPVRGGQIAPCDIKVEKGSTGMPPGPFLGELKSVGIPAAIEKGKIAIKEDKVVVKKGEVVSPKLAAVLDRLGIKPIKVGLNILAVYEDGIIYTPDVLKVDE 5dar B 2.90 BS01 NUC A 1 M9 A10 K13 V17 M36 D37 A40 P41 Q44 R47 R51 R57 M58 R60 N61 T62 L63 R66 R89 M1 A2 K5 V9 M28 D29 A32 P33 Q36 R39 R43 R49 M50 R52 N53 T54 L55 R58 R81 MAPWKIEEVKTLKGLIKSKPVVAIVDMMDVPAPQLQEIRDKIRDKVKLRMSRNTLIIRALKEAAEELNNPKLAELANYVERGAAILVTDMNPFKLYKLLEENKSPAPVRGGQIAPCKGEVVSPKLAAVLDRLGIKPIKVGLNILAVYEDGIIYTPDVLKV 5dar C 2.90 BS01 NUC A 1 L8 P71 T72 T73 K77 T84 A85 A86 H87 E88 P89 R90 H91 K109 A112 M113 L114 S115 Y116 N120 K123 E124 G127 T128 S131 M132 K142 Q145 L8 P71 T72 T73 K77 T84 A85 A86 H87 E88 P89 R90 H91 K109 A112 M113 L114 S115 Y116 N120 K123 E124 G127 T128 S131 M132 K142 Q145 AKEVVEVLVTGGRATAGPPLGPAIGPLGVNVMQVVKEINEKTKDYEGMQVPVKVIVDTETRKFEIEVGIPPTTALIKKELGIETAAHEPRHEVVGNLTLEQVIKIAKMKKDAMLSYTLKNAVKEVLGTCGSMGVTVEGKDPKEVQKEIDAGVYDEYFK 5dar E 2.90 BS01 NUC D 1 A10 K13 I14 V17 M35 M36 D37 P39 A40 P41 L43 Q44 R47 M58 R60 N61 T62 L63 R66 R89 G90 A2 K5 I6 V9 M27 M28 D29 P31 A32 P33 L35 Q36 R39 M50 R52 N53 T54 L55 R58 R81 G82 MAPWKIEEVKTLKGLIKSKPVVAIVDMMDVPAPQLQEIRDKIRDKVKLRMSRNTLIIRALKEAAEELNNPKLAELANYVERGAAILVTDMNPFKLYKLLEENKSPAPVRGGQIAPCDIKVEKGSTGMPPGPFLGELKSVGIPAAIEKGKIAIKEDKVVVKKGEVVSPKLAAVLDRLGIKPIKVGLNILAVYEDGIIYTPDVLKVD 5ddn B 2.11 BS01 5DX B 1 H88 S114 T116 R121 G135 I136 S173 T174 Y214 D215 A241 T243 Y245 H83 S109 T111 R116 G130 I131 S168 T169 Y209 D210 A236 T238 Y240 DNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH 5ddx B 1.95 BS01 5DY B 1 H88 S114 T116 N118 R121 G135 I136 G172 S173 T174 Y214 D215 A241 T243 Y245 H81 S107 T109 N111 R114 G128 I129 G165 S166 T167 Y207 D208 A234 T236 Y238 DNHLSIVTLEEAPFVIVEDIDTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGIC 5de3 A 1.42 BS01 GNP A 1 D25 N26 A27 G28 K29 T30 T31 I44 T47 G69 N125 K126 D128 L129 S158 A159 K160 D9 N10 A11 G12 K13 T14 T15 I28 T31 G53 N109 K110 D112 L113 S142 A143 K144 ARILVLGLDNAGKTTILKALSEEDITTITPTQGFNIKSLSRDGFNLKIWDIGGQKSIRPYWRNYFDQTDALIYVIDSADSKRLSESEFELTELLQEEKMTGVPLLVFANKQDLVGALAADEIASTLDLTSIRDRPWQIQACSAKQGTGLKEGMEWMMKQVKLEHHH 5de4 A 2.40 BS01 GLY A 1 F92 P124 L125 T126 R131 S180 D224 F250 F78 P107 L108 T109 R114 S163 D207 F233 RLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKGTRITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVR 5dex B 2.40 BS01 5E0 B 1 H88 S114 T116 R121 T134 G135 I136 G172 S173 T174 Y214 D215 T243 H82 S108 T110 R115 T128 G129 I130 G166 S167 T168 Y208 D209 T237 DNHLSIVTLEEAPFVIVEDIDPTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH 5df5 A 1.30 BS01 HEC A 1 K13 C14 C17 H18 E28 G29 P30 L35 T40 G41 Y48 T49 N52 W59 Y67 L68 T78 K79 M80 I81 F82 L94 K13 C14 C17 H18 E28 G29 P30 L35 T40 G41 Y48 T49 N52 W59 Y67 L68 T78 K79 M80 I81 F82 L94 GDVEKGKKIFVQKCAQCHTVEKGGKHKEGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE 5df5 B 1.30 BS02 FC6 B 1 K87 K88 G89 E90 K87 K88 G89 E90 GDVEKGKKIFVQKCAQCHTVEKGGKHKEGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE 5df5 B 1.30 BS03 FC6 B 2 D2 E4 K8 D2 E4 K8 GDVEKGKKIFVQKCAQCHTVEKGGKHKEGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE 5df5 C 1.30 BS02 FC6 C 1 K87 K88 G89 K87 K88 G89 GDVEKGKKIFVQKCAQCHTVEKGGKHKEGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE 5df5 D 1.30 BS01 HEC D 1 K13 C14 C17 H18 E28 G29 P30 T40 G41 F46 Y48 T49 N52 W59 L64 Y67 L68 T78 K79 M80 I81 F82 L94 K13 C14 C17 H18 E28 G29 P30 T40 G41 F46 Y48 T49 N52 W59 L64 Y67 L68 T78 K79 M80 I81 F82 L94 GDVEKGKKIFVQKCAQCHTVEKGGKHKEGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE 5dg1 C 3.20 BS01 GAL C 1 H48 N50 R52 E71 H43 N45 R47 E66 27563008 GELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLKE 5dg1 H 3.20 BS01 BGC H 1 S54 E55 S48 E49 27563008 ELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLKE 5dg1 I 3.20 BS01 GAL I 1 H48 N50 R52 W68 H42 N44 R46 W62 27563008 ELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLKE 5dg2 B 1.61 BS01 GAL B 1 H48 N50 R52 N61 W68 E71 H45 N47 R49 N58 W65 E68 27563008 MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLK 5dhp A 2.27 BS01 5AQ A 1 N122 E123 A162 Y163 S166 H223 N121 E122 A161 Y162 S165 H222 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED 5dhp A 2.27 BS02 5AQ C 1 G131 P132 G149 D150 A185 G130 P131 G148 D149 A184 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED 5dhp B 2.27 BS01 5AQ B 1 N122 E123 A162 Y163 S166 D222 H223 N118 E119 A158 Y159 S162 D218 H219 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIEDLEH 5dhp B 2.27 BS02 5AQ D 1 R148 D150 A185 I187 R144 D146 A181 I183 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIEDLEH 5dhp D 2.27 BS01 5AQ B 1 G131 P132 G149 D150 A185 I187 G118 P119 G136 D137 A172 I174 2.7.1.23 KYMITSKGDEKSDLLRLNMIAGYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhq A 2.29 BS02 5AK C 1 G131 P132 R148 G149 D150 A185 G130 P131 R147 G148 D149 A184 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED 5dhq C 2.29 BS01 5AK A 1 G131 P132 R148 G149 D150 A185 I187 G128 P129 R145 G146 D147 A182 I184 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhq D 2.29 BS02 5AK D 1 L49 E123 A162 Y163 S166 H223 L43 E113 A152 Y153 S156 H213 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhr C 2.31 BS02 5AJ C 1 G46 L49 N122 E123 A162 Y163 S166 D222 H223 G45 L48 N118 E119 A158 Y159 S162 D218 H219 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAGEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhr D 2.31 BS02 5AJ D 1 G46 N122 E123 A162 Y163 S166 H223 G46 N118 E119 A158 Y159 S162 H219 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhs B 2.62 BS02 5AG D 1 G131 P132 R148 G149 D150 G126 P127 R143 G144 D145 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYKEATYLALNESTVKSSGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIEDLEH 5dhs C 2.62 BS02 5AG C 1 L49 N122 E123 A162 Y163 S166 D222 H223 L48 N119 E120 A159 Y160 S163 D219 H220 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dht B 2.59 BS02 5A9 D 1 G131 P132 D150 A185 G123 P124 D142 A177 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAYQKVSYPLLKTTVKYEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIEDLEH 5dhu C 2.33 BS02 5A8 C 1 E123 A162 Y163 S166 D222 H223 E114 A153 Y154 S157 D213 H214 2.7.1.23 MKYMITSKGDEKSDLLRLNMIAGFGYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dkh A 1.70 BS01 5C0 A 1 V1408 F1409 L1412 P1413 E1417 L1418 Y1421 V1429 L1456 N1459 A1460 N1464 I1470 V32 F33 L36 P37 E41 L42 Y45 V53 L80 N83 A84 N88 I94 3.6.4.- SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEE 5dkh B 1.70 BS01 5C0 B 1 V1408 F1409 L1412 P1413 E1417 L1418 Y1421 V1429 A1460 N1464 I1470 V28 F29 L32 P33 E37 L38 Y41 V49 A80 N84 I90 3.6.4.- PKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAK 5dng A 1.80 BS01 ZN A 1 C922 C925 C942 C945 C16 C19 C36 C39 6.3.2.- 27569044 EILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYIG 5dng A 1.80 BS02 ZN A 2 C937 H939 C957 C960 C31 H33 C51 C54 6.3.2.- 27569044 EILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYIG 5dnm G 2.81 BS03 RAX G 1 E61 E64 E48 E51 AKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPKK 5dnn A 2.80 BS03 AUF A 1 L109 H113 L72 H76 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 5dnn H 2.80 BS02 NUC J 1 K28 T29 G50 I51 S52 S53 R83 S84 T85 K1 T2 G23 I24 S25 S26 R56 S57 T58 KTRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK 5do4 L 1.86 BS01 NUC A 1 D34 G35 R36 D30 G31 R32 3.4.21.5 27566147 GEADCGLRPLFEKKSLEDKTERELLESYIDGR 5do4 H 1.86 BS01 NUC A 1 H87 P88 R89 R98 R123 Q131 A132 E169 R170 P171 K174 D183 N184 F244 R245 L246 K248 W249 K252 H87 P88 R89 R98 R123 Q131 A132 E167 R168 P169 K172 D181 N182 F242 R243 L244 K246 W247 K250 3.4.21.5 27566147 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG 5do4 H 1.86 BS02 0G6 H 1 H43 Y47 E94 L96 D199 A200 G203 S205 S226 W227 G228 G230 G238 H43 Y47 E94 L96 D197 A198 G201 S203 S224 W225 G226 G228 G236 3.4.21.5 27566147 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG 5dql A 1.78 BS02 MG A 2 A276 A279 Q308 A276 A279 Q308 4.1.3.1,4.1.3.30 MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQF 5dql A 1.78 BS03 VGX A 1 W93 D108 C191 G192 H193 N313 S315 S317 T347 L348 W93 D108 C191 G192 H193 N313 S315 S317 T347 L348 4.1.3.1,4.1.3.30 MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQF 5dql B 1.78 BS01 MG B 1 W93 D108 D153 W93 D108 D153 4.1.3.1,4.1.3.30 MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQF 5e0y A 2.00 BS01 ZN A 1 H600 Q626 H42 Q68 2.7.11.1 NQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ 5e0y A 2.00 BS02 ZN A 2 K589 D592 K31 D34 2.7.11.1 NQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ 5epp A 1.88 BS01 III B 1 N33 D35 V38 F52 R53 G54 D55 T56 I70 L72 Y110 P137 Y138 L140 E141 A142 Y143 R144 P145 I175 N13 D15 V18 F32 R33 G34 D35 T36 I50 L52 Y90 P117 Y118 L120 E121 A122 Y123 R124 P125 I155 3.6.4.6 27407164 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIK 5erg B 2.20 BS01 SAM B 1 Q92 V94 G118 T119 G120 S121 G122 S123 F124 E139 F140 R144 R167 D168 V169 C170 D203 L204 P205 Q84 V86 G110 T111 G112 S113 G114 S115 F116 E131 F132 R136 R159 D160 V161 C162 D195 L196 P197 2.1.1.220 27582183 NCFSGYKDLIKEGDLTLIWVSRDNIKPVRMHSEEVFNTRYGSFPHKDIIGKPYGSQIAIRTFAFVHVLQPTPELWTLSLPHRTQIVYTPDSSYIMQRLNCSPHSRVIEAGTGSGSFSHAFARSVGHLFSFEFHHIRYEQALEEFKEHGLIDDNVTITHRDVCQGGFLIKKGDTTSYEFGNNETAASLNANVVFLDLPAPWDAIPHLDSVISVDEKVGLCCFSPCIEQVDKTLDVLEKYGWTDVEMVEIQGRQYESRRQMVRSLNDALERLRDIKRHKIKEGDSNYKWKEVTKMEAEIKSHTSYLTFAFKVVNRSRDDEKVNEIL 5etj A 2.30 BS01 IM5 A 1 S33 Y88 A116 G118 V195 F200 E201 V217 G218 M219 T242 N243 H257 S35 Y90 A118 G120 V197 F202 E203 V219 G220 M221 T244 N245 H259 2.4.2.1 26927977 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5etj A 2.30 BS03 PO4 B 1 P92 Q144 P94 Q146 2.4.2.1 26927977 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5etj B 2.30 BS01 IM5 B 1 Y88 A116 A117 G118 V195 F200 E201 V217 G218 M219 T242 N243 H257 V260 Y89 A117 A118 G119 V196 F201 E202 V218 G219 M220 T243 N244 H258 V261 2.4.2.1 26927977 LMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5etj C 2.30 BS01 PO4 A 2 M1 P92 Q144 M3 P94 Q146 2.4.2.1 26927977 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5etj E 2.30 BS04 PO4 F 2 M1 R148 M3 R150 2.4.2.1 26927977 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5ews G 2.00 BS01 GAL G 1 H48 N50 N61 W68 E71 H45 N47 N58 W65 E68 27563008 MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLK 5ews G 2.00 BS02 BGC G 1 E71 R73 E68 R70 27563008 MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLK 5ews H 2.00 BS01 GAL H 1 V35 H48 N50 W68 V32 H45 N47 W65 27563008 MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLK 5ews H 2.00 BS02 BGC H 1 R52 E71 R49 E68 27563008 MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLK 5ews I 2.00 BS01 GAL I 1 H48 R52 N61 E71 H45 R49 N58 E68 27563008 MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLK 5ews J 2.00 BS01 GAL J 1 H48 N50 R52 N61 E71 H45 N47 R49 N58 E68 27563008 MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLK 5ey0 B 1.60 BS01 ILE B 1 R61 M65 P72 Y75 T96 V97 F98 P99 P100 R61 M65 P72 Y75 T96 V97 F98 P99 P100 MSLLSKTRELNTLLQKHKGIAVDFKDVAQTISSVTVTNVFIVSRRGKILGSSLNELLKSQRIIQMLEERHIPSEYTERLMEVKQTESNIDIDNVLTVFPPENRELFIDSRTTIFPILGGGERLGTLVLGRVHDDFNENDLVLGEYAATVIGMEILREKHSEVEKEARDKAAITMAINSLSYSEKEAIEHIFEELGGTEGLLIASKVADRVGITRSVIVNALRKLESAGVIESRSLKGTFIKVKKEKFLDELEK 5ey0 B 1.60 BS02 GTP B 1 V22 F24 S43 R44 R45 K47 L49 E153 E157 K158 V22 F24 S43 R44 R45 K47 L49 E153 E157 K158 MSLLSKTRELNTLLQKHKGIAVDFKDVAQTISSVTVTNVFIVSRRGKILGSSLNELLKSQRIIQMLEERHIPSEYTERLMEVKQTESNIDIDNVLTVFPPENRELFIDSRTTIFPILGGGERLGTLVLGRVHDDFNENDLVLGEYAATVIGMEILREKHSEVEKEARDKAAITMAINSLSYSEKEAIEHIFEELGGTEGLLIASKVADRVGITRSVIVNALRKLESAGVIESRSLKGTFIKVKKEKFLDELEK 5ey0 A 1.60 BS01 ILE A 1 R61 M65 Y75 T96 V97 F98 P99 P100 R61 M65 Y75 T96 V97 F98 P99 P100 MSLLSKTRELNTLLQKHKGIAVDFKDVAQTISSVTVTNVFIVSRRGKILGSSLNELLKSQRIIQMLEERHIPSEYTERLMEVKQTESNIDIDNVLTVFPPENRELFIDSRTTIFPILGGGERLGTLVLGRVHDDFNENDLVLGEYAATVIGMEILREKHSEVEKEARDKAAITMAINSLSYSEKEAIEHIFEELGGTEGLLIASKVADRVGITRSVIVNALRKLESAGVIESRSKGTFIKVKKEKFLDELEK 5ey1 A 2.00 BS02 GTP A 1 V22 F24 S43 R44 R45 K47 L49 E153 I154 R156 E157 K158 E161 V22 F24 S43 R44 R45 K47 L49 E153 I154 R156 E157 K158 E161 MSLLSKTRELNTLLQKHKGIAVDFKDVAQTISSVTVTNVFIVSRRGKILGSSLNELLKSQRIIQMLEERHIPSEYTERLMEVKQTESNIDIDNVLTVFPPENRELFIDSRTTIFPILGGGERLGTLVLGRVHDDFNENDLVLGEYAATVIGMEILREKHSEVEKEARDKAAITMAINSLSYSEKEAIEHIFEELGEGLLIITRSVIVNALRKLESAGVIESRTFIKVKKEKFLDELEKSK 5fa9 A 2.30 BS01 DTT A 1 A158 L159 Q242 K262 A145 L146 Q229 K249 1.8.4.11 27551953 MIKEIYLAGGSFWGVEGYFRQIPGVKETDTGYANSDHAETVKIVYDSSVVSLQELLAHYFRIIDPTSLNKQGNDAGRQYRTGIYYVDDSMIKEINSFVKFMQKKYSRPIVVEVEKLKHFILAEDYHQDYLQKNPGGYCHIDLTLALKPLYDESKFKVPSKEELKKSLKPIQFSVTQEKATERPFTSEYDKFDAEGIYVDITTGKPLFSSLNKYDAGCGWPSFTKAITTQALQYLEDKSLGMNRTEVVSKTGGAHLGHVFDDGPADAGGLRYSINGAALRFIPYDKMEKEGYGDYLPYVKPTGN 5fa9 A 2.30 BS02 DTT A 2 S64 Q66 L223 N224 T236 S51 Q53 L210 N211 T223 1.8.4.11 27551953 MIKEIYLAGGSFWGVEGYFRQIPGVKETDTGYANSDHAETVKIVYDSSVVSLQELLAHYFRIIDPTSLNKQGNDAGRQYRTGIYYVDDSMIKEINSFVKFMQKKYSRPIVVEVEKLKHFILAEDYHQDYLQKNPGGYCHIDLTLALKPLYDESKFKVPSKEELKKSLKPIQFSVTQEKATERPFTSEYDKFDAEGIYVDITTGKPLFSSLNKYDAGCGWPSFTKAITTQALQYLEDKSLGMNRTEVVSKTGGAHLGHVFDDGPADAGGLRYSINGAALRFIPYDKMEKEGYGDYLPYVKPTGN 5fa9 B 2.30 BS01 DTT B 1 L223 N224 T236 L210 N211 T223 1.8.4.11 27551953 MIKEIYLAGGSFWGVEGYFRQIPGVKETDTGYANSDHAETVKIVYDSSVVSLQELLAHYFRIIDPTSLNKQGNDAGRQYRTGIYYVDDSMIKEINSFVKFMQKKYSRPIVVEVEKLKHFILAEDYHQDYLQKNPGGYCHIDLTLALKPLYDESKFKVPSKEELKKSLKPIQFSVTQEKATERPFTSEYDKFDAEGIYVDITTGKPLFSSLNKYDAGCGWPSFTKAITTQALQYLEDKSLGMNRTEVVSKTGGAHLGHVFDDGPADAGGLRYSINGAALRFIPYDKMEKEGYGDYLPYVKPTGNF 5fa9 B 2.30 BS02 DTT B 2 P23 L159 K160 P161 Q242 K262 P23 L146 K147 P148 Q229 K249 1.8.4.11 27551953 MIKEIYLAGGSFWGVEGYFRQIPGVKETDTGYANSDHAETVKIVYDSSVVSLQELLAHYFRIIDPTSLNKQGNDAGRQYRTGIYYVDDSMIKEINSFVKFMQKKYSRPIVVEVEKLKHFILAEDYHQDYLQKNPGGYCHIDLTLALKPLYDESKFKVPSKEELKKSLKPIQFSVTQEKATERPFTSEYDKFDAEGIYVDITTGKPLFSSLNKYDAGCGWPSFTKAITTQALQYLEDKSLGMNRTEVVSKTGGAHLGHVFDDGPADAGGLRYSINGAALRFIPYDKMEKEGYGDYLPYVKPTGNF 5g3l D 1.72 BS01 SIA D 1 T13 T14 W92 T13 T14 W92 27562297 GASQFFKDNCNRTTASLVEGVELTKYISDINNNTDGMYVVSSTGGVWRISRAKDYPDNVMTAEMRKIAMAAVLSGMRVNMCASPASSPNVIWAIELEAE 5g3l D 1.72 BS02 SIA H 1 I30 N31 N32 I30 N31 N32 27562297 GASQFFKDNCNRTTASLVEGVELTKYISDINNNTDGMYVVSSTGGVWRISRAKDYPDNVMTAEMRKIAMAAVLSGMRVNMCASPASSPNVIWAIELEAE 5g3l F 1.72 BS01 SIA E 1 N31 N32 N31 N32 27562297 GASQFFKDNCNRTTASLVEGVELTKYISDINNNTDGMYVVSSTGGVWRISRAKDYPDNVMTAEMRKIAMAAVLSGMRVNMCASPASSPNVIWAIELEA 5g3l G 1.72 BS02 SIA G 2 R51 A52 K53 D54 R51 A52 K53 D54 27562297 GASQFFKDNCNRTTASLVEGVELTKYISDINNNTDGMYVVSSTGGVWRISRAKDYPDNVMTAEMRKIAMAAVLSGMRVNMCASPASSPNVIWAIELEA 5g3m A 1.85 BS02 9JH A 1 L5 A6 P17 Y20 M21 F26 C27 G28 H46 D47 I94 L5 A6 P17 Y20 M21 F26 C27 G28 H46 D47 I94 3.1.1.4 GILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD 5g3m B 1.85 BS02 9JH B 1 I2 L5 P17 Y20 F26 C27 G28 H46 D47 I94 I2 L5 P17 Y20 F26 C27 G28 H46 D47 I94 3.1.1.4 GILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD 5g3n A 1.80 BS03 X28 A 1 L2 F5 H6 I9 A17 A18 G22 H27 C28 G29 V30 G31 C44 H47 D48 Y51 K62 L2 F5 H6 I9 A17 A18 G22 H27 C28 G29 V30 G31 C44 H47 D48 Y51 K62 3.1.1.4 ALVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRISCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRCGHH 5g3n B 1.80 BS02 CA B 2 F23 Y24 G25 Y112 F23 Y24 G25 Y112 3.1.1.4 ALVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRISCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC 5gin A 3.31 BS01 NUC G 1 R145 S293 T294 Q296 L304 F305 R143 S291 T292 Q294 L302 F303 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gin A 3.31 BS02 NUC H 1 K152 L156 E159 R160 E163 Q296 G299 A300 K302 A303 R306 R313 P314 P315 K316 H317 G318 F321 G335 K336 R339 A343 K344 R370 K150 L154 E157 R158 E161 Q294 G297 A298 K300 A301 R304 R311 P312 P313 K314 H315 G316 F319 G333 K334 R337 A341 K342 R368 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gin A 3.31 BS04 NUC J 1 N155 E159 E177 H179 N153 E157 E175 H177 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gin C 3.31 BS02 NUC H 1 K37 G38 T39 N40 E41 V60 Q61 I65 K86 L95 A98 T99 A100 K31 G32 T33 N34 E35 V54 Q55 I59 K80 L89 A92 T93 A94 ASYVKFEVPQDLADKVLEAVRKAKESGKIKKGTNETTKAVERGQAKLVIIAEDVQPEEIVAHLPLLCDEKKIPYVYVSSKKALGEACGLQVATASAAILEPGEAKDLVDEIIKRVNEIKGKT 5gin E 3.31 BS01 NUC G 1 S110 R112 A155 P157 R184 S185 D187 V188 S106 R108 A151 P153 R180 S181 D183 V184 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gin E 3.31 BS02 NUC I 1 F57 R58 K60 S87 T89 E116 K182 R184 S185 V188 D220 K221 H223 F53 R54 K56 S83 T85 E112 K178 R180 S181 V184 D216 K217 H219 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gin E 3.31 BS03 SAH E 1 Y82 G84 A86 T90 E108 F109 S110 A132 D133 A134 D153 A155 Q156 Y78 G80 A82 T86 E104 F105 S106 A128 D129 A130 D149 A151 Q152 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gin B 3.31 BS02 NUC H 1 R145 S293 T294 Q296 V297 E301 L304 F305 L308 P314 R339 K377 R143 S291 T292 Q294 V295 E299 L302 F303 L306 P312 R337 K375 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gin B 3.31 BS03 NUC I 1 N155 E159 H179 N153 E157 H177 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gin F 3.31 BS01 NUC H 1 F109 S110 R112 V113 A155 Q156 P157 R184 S185 D187 V188 F105 S106 R108 V109 A151 Q152 P153 R180 S181 D183 V184 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gin F 3.31 BS02 NUC J 1 R58 K60 S87 T89 E116 K182 R184 V188 D220 K221 H223 R54 K56 S83 T85 E112 K178 R180 V184 D216 K217 H219 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gin F 3.31 BS03 SAH F 1 Y82 G84 A86 T90 E108 F109 D133 A134 D153 I154 A155 Y78 G80 A82 T86 E104 F105 D129 A130 D149 I150 A151 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gin K 3.31 BS01 NUC N 1 R145 S293 T294 Q296 L304 F305 K377 R143 S291 T292 Q294 L302 F303 K375 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gin M 3.31 BS01 NUC N 1 F109 S110 R112 A155 P157 R184 S185 D187 V188 F105 S106 R108 A151 P153 R180 S181 D183 V184 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gin M 3.31 BS02 NUC O 1 Y39 F57 R58 K60 S87 T89 E116 K182 R184 D220 K221 H223 Y35 F53 R54 K56 S83 T85 E112 K178 R180 D216 K217 H219 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gio A 3.60 BS01 NUC G 1 R145 S293 T294 Q296 L304 F305 L308 P314 K377 R143 S291 T292 Q294 L302 F303 L306 P312 K375 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gio E 3.60 BS03 SAH E 1 Y82 G84 A86 T89 T90 E108 F109 S110 A132 D133 A134 D153 I154 A155 Q156 Y78 G80 A82 T85 T86 E104 F105 S106 A128 D129 A130 D149 I150 A151 Q152 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gio B 3.60 BS02 NUC H 1 R145 P291 S293 T294 Q296 V297 E301 L304 F305 P314 K377 R143 P289 S291 T292 Q294 V295 E299 L302 F303 P312 K375 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gio K 3.60 BS01 NUC N 1 R145 S293 T294 Q296 E301 L304 F305 P314 K377 R143 S291 T292 Q294 E299 L302 F303 P312 K375 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gio M 3.60 BS01 NUC N 1 S110 R112 A155 Q156 R184 S185 D187 V188 S106 R108 A151 Q152 R180 S181 D183 V184 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gio M 3.60 BS03 SAH M 1 K60 Y82 G84 A86 T90 E108 F109 S110 D133 A134 D153 I154 A155 Q156 K56 Y78 G80 A82 T86 E104 F105 S106 D129 A130 D149 I150 A151 Q152 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gip A 3.13 BS01 NUC G 1 R145 S293 T294 Q296 V297 E301 F305 R143 S291 T292 Q294 V295 E299 F303 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gip A 3.13 BS04 NUC J 1 N155 E159 H179 R276 F321 Q322 H327 N153 E157 H177 R274 F319 Q320 H325 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gip B 3.13 BS02 NUC H 1 R145 S293 T294 Q296 E301 F305 P314 K377 R143 S291 T292 Q294 E299 F303 P312 K375 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gip B 3.13 BS03 NUC I 1 D151 N155 E159 H179 R276 F321 Q322 H327 D149 N153 E157 H177 R274 F319 Q320 H325 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gip B 3.13 BS04 NUC J 1 E301 K302 F305 R306 R309 E299 K300 F303 R304 R307 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gip E 3.13 BS01 NUC G 1 F109 S110 A155 Q156 P157 R184 S185 V188 F105 S106 A151 Q152 P153 R180 S181 V184 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gip F 3.13 BS02 NUC J 1 F57 R58 K60 S87 T89 K182 R184 D220 K221 H223 F53 R54 K56 S83 T85 K178 R180 D216 K217 H219 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gip K 3.13 BS01 NUC Q 1 R145 S293 T294 Q296 E301 L304 F305 L308 R143 S291 T292 Q294 E299 L302 F303 L306 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gip L 3.13 BS02 NUC R 1 R145 S293 T294 Q296 V297 E301 L304 F305 R143 S291 T292 Q294 V295 E299 L302 F303 KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATVELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAIDIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKELGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEKALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVDAFSGRFIGDQLNEQLKKRIDEIKEK 5gip O 3.13 BS01 NUC Q 1 S110 A155 Q156 P157 R184 S185 D187 V188 S106 A151 Q152 P153 R180 S181 D183 V184 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gip P 3.13 BS01 NUC R 1 S110 R112 A155 Q156 P157 R184 S185 V188 S106 R108 A151 Q152 P153 R180 S181 V184 2.1.1.- ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYK 5gir H 1.93 BS01 III C 1 Y27 Y32 W33 N35 M50 T94 H95 F96 D101 Y102 Y26 Y31 W32 N34 M49 T97 H98 F99 D100 Y101 27553275 VQLQQPGAELVRPGASVKLSCKASGYTFTSYWMNWVKQRPGQGLECIGMIHPSDGETRLNQKFKDKATLTLDKSSSTAYMQLSSPTSEDSAVYYCTTHFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR 5gir L 1.93 BS01 III C 1 H34 L46 R49 Y50 I55 S91 F96 H34 L46 R49 Y50 I55 S91 F96 27553275 DIVLIQSPATLSVTPGDSVSLSCRASQRISNNLHWYQQKSHESPRLLIRYTSQSISGIPSRFSGSGSGTDFTLSINSVETEDFGMYFCQQSNSWPFTFGSGTKLEMKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN 5gir A 1.93 BS01 III D 1 Y27 Y32 W33 N35 T94 H95 F96 D101 Y102 Y26 Y31 W32 N34 T97 H98 F99 D100 Y101 27553275 VQLQQPGAELVRPGASVKLSCKASGYTFTSYWMNWVKQRPGQGLECIGMIHPSDGETRLNQKFKDKATLTLDKSSSTAYMQLSSPTSEDSAVYYCTTHFDYWGQGTTLTVSSAKTTAPSVYPLAPVCSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR 5gir B 1.93 BS01 III D 1 H34 L46 R49 Y50 I55 S56 S91 F96 H34 L46 R49 Y50 I55 S56 S91 F96 27553275 DIVLIQSPATLSVTPGDSVSLSCRASQRISNNLHWYQQKSHESPRLLIRYTSQSISGIPSRFSGSGSGTDFTLSINSVETEDFGMYFCQQSNSWPFTFGSGTKLEMKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR 5gis H 1.93 BS01 III C 1 Y27 Y32 W33 N35 T94 H95 D101 Y102 Y26 Y31 W32 N34 T97 H98 D100 Y101 27553275 VQLQQPGAELVRPGASVKLSCKASGYTFTSYWMNWVKQRPGQGLECIGMIHPSDGETRLNQKFKDKATLTLDKSSSTAYMQLSSPTSEDSAVYYCTTHFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRG 5gjv A 3.60 BS01 CA A 1 E292 E614 E1014 G1322 E240 E522 E798 G1083 27580036 FCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMWNRVFRWKCHDLVKSRVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGLRQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESVRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHYHQSEEMNHISDILNVAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFRISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGD 5gjv F 3.60 BS01 CA F 1 S263 S265 T333 D365 G366 S213 S215 T283 D315 G316 27580036 FPSAVTIKSWVDKMQEDLVTLAKTASGVHQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASVVYYNAKDQRIKPVFIDDANFRRQVSYQHAAVHIPTDIYEGSTIVLNELNWTSALDDVFKKNREEDPSLLWQVFGSATGLARYYPASPWVKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNVQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESGYTFLAPRDYCSDLKPSDNNTEFLLNFNEFIDRKTTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAASKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDC 5gjw A 3.90 BS01 CA A 1 E292 E614 F1013 E1014 G1322 E240 E521 F812 E813 G1098 27580036 FCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMNRVFRWKCHDLVKSRVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGLRQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMVRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHYHQSEEMNHISDILNVAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFRISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGD 5gjw F 3.90 BS01 CA F 1 S263 S265 T333 S213 S215 T283 27580036 FPSAVTIKSWVDKMQEDLVTLAKTASGVHQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASVVYYNAKDQRIKPVFIDDANFRRQVSYQHAAVHIPTDIYEGSTIVLNELNWTSALDDVFKKNREEDPSLLWQVFGSATGLARYYPASPWVKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNVQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESGYTFLAPRDYCSDLKPSDNNTEFLLNFNEFIDRKTTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAASKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDC 5hgv A 2.05 BS01 III B 1 K396 S494 H496 H517 N557 H558 P559 Y632 T633 K634 Q839 V895 A896 P897 K83 S181 H183 H204 N244 H245 P246 Y319 T320 K321 Q506 V562 A563 P564 2.4.1.255 PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSNFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKHIYDNRIVLNGIDLKAFLDSLPDVKIVKNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK 5hgv A 2.05 BS03 NAG B 1 H498 M501 P559 T560 L563 L653 G654 P656 F694 Y841 H920 T921 H185 M188 P246 T247 L250 L340 G341 P343 F381 Y508 H587 T588 2.4.1.255 PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSNFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKHIYDNRIVLNGIDLKAFLDSLPDVKIVKNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK 5hgz A 1.38 BS01 ACO A 1 W33 F34 L99 S100 L101 G102 V103 R108 K109 H110 G111 G113 S114 H138 N143 T145 A146 F149 Y150 N152 R153 W33 F34 L99 S100 L101 G102 V103 R108 K109 H110 G111 G113 S114 H138 N143 T145 A146 F149 Y150 N152 R153 2.3.1.48,2.3.1.88 27550639 MTEEERSSALSEVSLRLLCHDDIDTVKHLCGDWFPIEYPDSWYRDITSNKKFFSLAATYRGAIVGMIVAEIKNRTKIHKEDGDILASNFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHISTTAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVLKDGFTYVLYINGGHPPWTILDYIQHLGSALASLSPCSIPH 5hh0 A 1.60 BS01 COA A 1 W33 S100 L101 G102 V103 R108 K109 H110 G111 G113 S114 N143 T145 F149 N152 R153 W29 S96 L97 G98 V99 R104 K105 H106 G107 G109 S110 N139 T141 F145 N148 R149 2.3.1.48,2.3.1.88 27550639 ERSSALSEVSLRLLCHDDIDTVKHLCGDWFPIEYPDSWYRDITSNKKFFSLAATYRGAIVGMIVAEIKNRTKIHKEDGDILASNFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHISTTAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVLKDGFTYVLYINGGHPPWTILDYIQHLGS 5hit A 2.85 BS01 III B 1 E84 A88 N111 L112 G113 M144 M145 E81 A85 N108 L109 G110 M141 M142 ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 5hsj A 1.90 BS01 PLP A 1 D157 G158 S159 N162 H241 T298 D328 A330 D389 H391 K392 D151 G152 S153 N156 H235 T292 D322 A324 D383 H385 K386 4.1.1.25 27292129 SLKDLDLNALFIGDKAENGQLYKDLLNKLVDEHLGWRKNYIPSDPNMIGPEDQNSPAFKKTVGHMKTVLDQLSERIRTESVPWHSAGRYWGHMNSETLMPALLAYNYAMLWNGNNVAYESSPATSQMEEEVGQEFARLMGYDYGWGHIVADGSLANLEGLWYARNIKSLPFAMKEVNPELVAGKSDWELLNMPTKEIMDLLENAGSQIDEVKKRSARSGKNLQRLGKWLVPQTKHYSWMKAADIIGIGLDQVVPVPIDSNYRMDIQALESIIRKYAAEKTPILGVVGVAGSTEEGAVDGIDKIVALRQKLQKEGIYFYLHVDAAYGGYARALFLDEDDQFIPYKNLQKVHAENHVFTEDKEYIKPEVYAAYKAFDQAESITIDPHKMGYVPYSAGGIVIQDIRMRDTISYFAGADIPALLGAYILEGSKAGATAASVWAAHHTLPLNVTGYGKLEGASIEGAHRYYDFLKNLKFEVAGKRISVHPLISPDFNMVDYVLKEDGNDDLIEMNRLNHAFYEQASYVKGSLYGKEYIVSHTDFAIPDYGDSPLAFVESLGFSEVEWRHAGKVTIIRASVMTPYMNQRENFDYFAPRIKKAIQADLEKVYA 5hsj A 1.90 BS02 PLP B 1 G439 S440 G427 S428 4.1.1.25 27292129 SLKDLDLNALFIGDKAENGQLYKDLLNKLVDEHLGWRKNYIPSDPNMIGPEDQNSPAFKKTVGHMKTVLDQLSERIRTESVPWHSAGRYWGHMNSETLMPALLAYNYAMLWNGNNVAYESSPATSQMEEEVGQEFARLMGYDYGWGHIVADGSLANLEGLWYARNIKSLPFAMKEVNPELVAGKSDWELLNMPTKEIMDLLENAGSQIDEVKKRSARSGKNLQRLGKWLVPQTKHYSWMKAADIIGIGLDQVVPVPIDSNYRMDIQALESIIRKYAAEKTPILGVVGVAGSTEEGAVDGIDKIVALRQKLQKEGIYFYLHVDAAYGGYARALFLDEDDQFIPYKNLQKVHAENHVFTEDKEYIKPEVYAAYKAFDQAESITIDPHKMGYVPYSAGGIVIQDIRMRDTISYFAGADIPALLGAYILEGSKAGATAASVWAAHHTLPLNVTGYGKLEGASIEGAHRYYDFLKNLKFEVAGKRISVHPLISPDFNMVDYVLKEDGNDDLIEMNRLNHAFYEQASYVKGSLYGKEYIVSHTDFAIPDYGDSPLAFVESLGFSEVEWRHAGKVTIIRASVMTPYMNQRENFDYFAPRIKKAIQADLEKVYA 5hua A 1.30 BS01 FK5 A 1 Y33 F43 D44 R49 F53 Q61 V62 I63 W66 A88 Y89 F94 F106 Y32 F42 D43 R48 F52 Q60 V61 I62 W65 A87 Y88 F93 F105 5.2.1.8 27118592 SETIEGGVKIDRLSPGDGKTFPKQGDLVTIHYTGTLENGQKFDSSVDRGSPFQCNIGVGQVIKGWDAGIPKLSVGEKARLTIPGPYAYGPRGFPGLIPPNATLIFDVELLKVN 5hw8 A 2.86 BS01 FK5 A 1 Y30 D41 R46 F50 Q58 V59 I60 W63 A96 Y97 I106 Y26 D37 R42 F46 Q54 V55 I56 W59 A92 Y93 I102 5.2.1.8 27118592 LPQIEIVQEGDNTTFAKPGDTVTIHYDGKLTNGKEFDSSRKRGKPFTCTVGVGQVIKGWDISLTNNYGKGGANLPKISKGTKAILTIPPNLAYGPRGIPGIIGPNETLVFEVELLGVNGQ 5hw8 B 2.86 BS01 FK5 B 1 Y30 F40 D41 F50 V59 I60 W63 A96 Y97 I105 I106 F114 Y28 F38 D39 F48 V57 I58 W61 A94 Y95 I103 I104 F112 5.2.1.8 27118592 EELPQIEIVQEGDNTTFAKPGDTVTIHYDGKLTNGKEFDSSRKRGKPFTCTVGVGQVIKGWDISLTNNYGKGGANLPKISKGTKAILTIPPNLAYGPRGIPGIIGPNETLVFEVELLGVNGQ 5hw8 C 2.86 BS01 FK5 C 1 Y30 F40 D41 R46 F50 Q58 V59 I60 W63 Y97 F114 Y27 F37 D38 R43 F47 Q55 V56 I57 W60 Y94 F111 5.2.1.8 27118592 ELPQIEIVQEGDNTTFAKPGDTVTIHYDGKLTNGKEFDSSRKRGKPFTCTVGVGQVIKGWDISLTNNYGKGGANLPKISKGTKAILTIPPNLAYGPRGIPGIIGPNETLVFEVELLGVNGQ 5hw8 H 2.86 BS01 FK5 H 1 Y30 F40 D41 F50 Q58 V59 I60 W63 I105 F114 Y18 F28 D29 F38 Q46 V47 I48 W51 I84 F93 5.2.1.8 27118592 QIEIVQEAKPGDTVTIHYDGKLTNGKEFDSSRKRGKPFTCTVGVGQVIKGWDISLTNNYPKISKGTKAILTIPPNLAPRGIPGIIGPNETLVFEVELLGV 5hwc A 2.05 BS01 FK5 A 1 Y27 F37 D38 R43 F47 R55 V56 I57 W60 G82 Y83 F88 I92 F100 Y28 F38 D39 R44 F48 R56 V57 I58 W61 G83 Y84 F89 I93 F101 5.2.1.8 27118592 HMGVTKELKSPGNGVDFPKKGDFVTIHYTGRLTDGSKFDSSVDRNEPFQTQIGTGRVIKGWDEGVPQMSLGEKAVLTITPDYGYGARGFPGVIPGNSTLIFEVELLGINNKRA 5isy A 2.35 BS02 NAD A 1 C130 I132 F160 Q192 W194 F196 S199 M201 T239 V240 A241 C129 I131 F159 Q191 W193 F195 S198 M200 T238 V239 A240 3.6.1.22 27561816 DRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLVQQQRRHDMGSVRQVIDLDVGLFQLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEQSGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGDIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCEY 5isy A 2.35 BS03 NAD C 1 E111 Y124 E110 Y123 3.6.1.22 27561816 DRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLVQQQRRHDMGSVRQVIDLDVGLFQLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEQSGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGDIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCEY 5isy C 2.35 BS03 NAD C 1 A128 C130 F160 W194 F196 S199 M201 V240 A241 A126 C128 F158 W192 F194 S197 M199 V238 A239 3.6.1.22 27561816 DRIIEKDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLVQQQRRHDMGSVRQVIDLDVGLFQLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEQSGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGDIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAM 5ixs A 2.05 BS01 TXD A 1 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 A97 R98 I115 V135 N137 L164 H192 T247 I251 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 A97 R98 I111 V131 N133 L160 H188 T243 I247 1.1.1.27 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQSRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5ixs A 2.05 BS02 6EY A 1 R98 N137 L164 D165 R168 H192 G193 V234 A237 Y238 I241 T247 R98 N133 L160 D161 R164 H188 G189 V230 A233 Y234 I237 T243 1.1.1.27 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQSRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5ixs B 2.05 BS01 TXD B 1 G28 A29 V30 D51 V52 I53 K56 T94 A95 A97 R98 I115 V135 N137 H192 T247 I251 G28 A29 V30 D51 V52 I53 K56 T94 A95 A97 R98 I108 V128 N130 H185 T240 I244 1.1.1.27 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5ixs B 2.05 BS02 6EY B 1 R98 N137 L164 D165 R168 H192 G193 V233 V234 A237 Y238 I241 Y246 T247 R98 N130 L157 D158 R161 H185 G186 V226 V227 A230 Y231 I234 Y239 T240 1.1.1.27 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5ixs D 2.05 BS01 TXD D 1 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 A97 R98 I115 I119 V135 S136 N137 L164 H192 T247 I251 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 A97 R98 I114 I118 V134 S135 N136 L163 H191 T246 I250 1.1.1.27 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5ixs D 2.05 BS02 6EY D 1 R98 Q99 N137 D165 R168 H192 G193 V234 A237 Y238 I241 T247 R98 Q99 N136 D164 R167 H191 G192 V233 A236 Y237 I240 T246 1.1.1.27 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5ixy A 3.00 BS01 NAD A 1 V25 G28 A29 V30 D51 V52 I53 K56 T94 A95 G96 R98 I115 I119 V135 S136 N137 L164 H192 I251 V25 G28 A29 V30 D51 V52 I53 K56 T94 A95 G96 R98 I115 I119 V135 S136 N137 L164 H192 I251 1.1.1.27 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5ixy D 3.00 BS01 NAD D 1 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 I115 F118 I119 V135 S136 N137 L164 H192 I251 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 I112 F115 I116 V132 S133 N134 L161 H189 I248 1.1.1.27 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 5ja1 A 3.00 BS01 75C A 1 F647 D648 V649 R673 V693 S722 G723 E724 A725 N744 L745 Y746 G747 P748 T749 V753 D754 I775 D840 Y852 R855 K861 R863 G864 Q865 R866 S1006 F619 D620 V621 R645 V665 S694 G695 E696 A697 N716 L717 Y718 G719 P720 T721 V725 D726 I747 D812 Y824 R827 K833 R835 G836 Q837 R838 S972 2.7.7.- 27597544 SELPSAWSVAHYVELTGEVDSPLLARAVVAGLAQADTLRMRFTVWQWVDDALTFELPEIIDLRTNIDPHGTAQALMQADLQQDLRVDSGKPLVFHQLIQVADNRWYWYQRYHHLLVDGFSFPAITRQIANIYCTWLRGEPTPASPFTPFADVVEEYQQYRESEAWQRDAAFWAEQRRQLPPPASLSPAPLPGRSASADILRLKLEFTDGEFRQLATQLSGVQRTDLALALAALWLGRLCNRMDYAAGFIFMRRLGSAALTATGPVLNVLPLGIHIAAQETLPELATRLAAQLKKMRRHQRYDAEQIVRDSAGDEPLFGPVLNIKVFDYQLDIPDVQAQTHTLATGPVNDLELALFPDVHGDLSIEILANKQRYDEPTLIQHAERLKMLIAQFAADPALLCGDVDIMLPGEYAQLAQLNATQVEIPETTLSALVAEQAAKTPDAPALADARYLFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLEDARPSLLITTDDQLPRFSDVPNLTSLCYNAPLTPQGSAPLQLSQPHHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPLTGEDVVAQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTTHFVPSMLAAFVASLTPQTARQSCATLKQVFCSGEALPADLCREWQQLTGAPLHNLYGPTEAAVDVSWYPAFGEELAQVRGSSVPIGYPVWNTGLRILDAMMHPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFAPGERMYRTGDVARWLDNGAVEYLGRSDDQLKIRGQRIELGEIDRVMQALPDVEQAVTHACVINQAAATGGDARQLVGYLVSQSGLPLDTSALQAQLRETLPPHMVPVVLLQLPQLPLSANGKLDRKALPLPELRAPKAGSETIIAAAFSSLLGCDVQDADADFFALGGHSLLAMKLAAQLSRQVARQVTPGQVMVASTVAKLATIMGFETILPLREGNGPTLFCFHPASGFAWQFSVLSRYLDPQWSIIGIQSPRPNGPMQTAANLDEVCEAHLATLLEQQPHGPYYLLGYSLGGTLAQGIAARLRARGEQVAFLGLLDTWPPETLDPEVLAEINREREAFLAAQQGSTELFTTIEGNYADAVRLLTTAHSVPFDGKATLFVAERTSPERAWSPWIAELDIYRQDCAHVDIISPGTFEKIGPIIRATLN 5ja2 A 3.00 BS02 BU9 A 1 S606 K611 S822 R823 R837 S583 K588 S799 R800 R814 2.7.7.- 27597544 EKLSELPSAWSVAHYVELTGEVDSPLLARAVVAGLAQADTLRMRFTEVWQWVDDALTFELPEIIDLRTNIDPHGTAQALMQADLQQDLRVDSGKPLVFHQLIQVADNRWYWYQRYHHLLVDGFSFPAITRQIANIYCTWLRGEPTPASPFTPFADVVEEYQQYRESEAWQRDAAFWAEQRRQLPPPASLSPAPLPGRSASADILRLKLEFTDGEFRQLATQLSGVQRTDLALALAALWLGRLCNRMDYAAGFIFMRRLGSAALTATGPVLNVLPLGIHIAAQETLPELATRLAAQLKKMRRHQRYDAEQIVRDSAAGDEPLFGPVLNIKVFDYQLDIPDVQAQTHTLATGPVNDLELALFPDVHGDLSIEILANKQRYDEPTLIQHAERLKMLIAQFAADPALLCGDVDIMLPGEYAQLAQLNATQVEIPETTLSALVAEQAAKTPDAPALADARYLFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLEDARPSLLITTDDQLPRFSDVPNLTSLCYNAPLTPQGSAPLQLSQPHHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPLTGEDVVAQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTTHFVPSMLAAFVASLTPQTARQSCATLKQVFCSGEALPADLCREWQQLTGAPLHNLYGPTEAAVDVSWYPAFGEELAQVRGSSVPIGYPVWNTGLRILDAMMHPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFAPGERMYRTGDVARWLDNGAVEYLGRSDDQLKIRGQRIELGEIDRVMQALPDVEQAVTHACVINQAAATGGDARQLVGYLVSQSGLPLDTSALQAQLRETLPPHMVPVVLLQLPQLPLSANGKLDRKALPLPELAPKAGSETIIAAAFSSLLGCDVQDADADFFALGGHSLLAMKLAAQLSRQVARQVTPGQVMVASTVAKLATIIDRMGFETILPLREGNGPTLFCFHPASGFAWQFSVLSRYLDPQWSIIGIQSPRPNGPMQTAANLDEVCEAHLATLLEQQPHGPYYLLGYSLGGTLAQGIAARLRAREQVAFLGLLDTWPPETLDPEVLAEINREREAFLAAQQGELFTTIEGNYADAVRLLTTAHSVPFDGKATLFVAERTLQEGMSPERAWSPWELDIYRQDCAHVDIISPGTFEKIGPIIRATLN 5ja2 A 3.00 BS03 BU9 A 2 L109 R110 S113 K115 P116 R135 L88 R89 S92 K94 P95 R114 2.7.7.- 27597544 EKLSELPSAWSVAHYVELTGEVDSPLLARAVVAGLAQADTLRMRFTEVWQWVDDALTFELPEIIDLRTNIDPHGTAQALMQADLQQDLRVDSGKPLVFHQLIQVADNRWYWYQRYHHLLVDGFSFPAITRQIANIYCTWLRGEPTPASPFTPFADVVEEYQQYRESEAWQRDAAFWAEQRRQLPPPASLSPAPLPGRSASADILRLKLEFTDGEFRQLATQLSGVQRTDLALALAALWLGRLCNRMDYAAGFIFMRRLGSAALTATGPVLNVLPLGIHIAAQETLPELATRLAAQLKKMRRHQRYDAEQIVRDSAAGDEPLFGPVLNIKVFDYQLDIPDVQAQTHTLATGPVNDLELALFPDVHGDLSIEILANKQRYDEPTLIQHAERLKMLIAQFAADPALLCGDVDIMLPGEYAQLAQLNATQVEIPETTLSALVAEQAAKTPDAPALADARYLFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLEDARPSLLITTDDQLPRFSDVPNLTSLCYNAPLTPQGSAPLQLSQPHHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPLTGEDVVAQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTTHFVPSMLAAFVASLTPQTARQSCATLKQVFCSGEALPADLCREWQQLTGAPLHNLYGPTEAAVDVSWYPAFGEELAQVRGSSVPIGYPVWNTGLRILDAMMHPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFAPGERMYRTGDVARWLDNGAVEYLGRSDDQLKIRGQRIELGEIDRVMQALPDVEQAVTHACVINQAAATGGDARQLVGYLVSQSGLPLDTSALQAQLRETLPPHMVPVVLLQLPQLPLSANGKLDRKALPLPELAPKAGSETIIAAAFSSLLGCDVQDADADFFALGGHSLLAMKLAAQLSRQVARQVTPGQVMVASTVAKLATIIDRMGFETILPLREGNGPTLFCFHPASGFAWQFSVLSRYLDPQWSIIGIQSPRPNGPMQTAANLDEVCEAHLATLLEQQPHGPYYLLGYSLGGTLAQGIAARLRAREQVAFLGLLDTWPPETLDPEVLAEINREREAFLAAQQGELFTTIEGNYADAVRLLTTAHSVPFDGKATLFVAERTLQEGMSPERAWSPWELDIYRQDCAHVDIISPGTFEKIGPIIRATLN 5jiy A 1.48 BS01 III F 1 D1074 A1077 D1078 R1080 D1083 L1086 F1087 D1088 N1091 P1121 R1123 Y1154 R1157 F1158 K1162 D159 A162 D163 R165 D168 L171 F172 D173 N176 P206 R208 Y239 R242 F243 K247 2.1.1.-,2.1.1.43 27185940 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR 5jiy A 1.48 BS06 SAM A 1 M1048 W1050 S1084 Y1085 R1109 F1110 I1111 N1112 H1113 Y1154 F1158 F1166 T1167 C1168 Q1169 M133 W135 S169 Y170 R194 F195 I196 N197 H198 Y239 F243 F251 T252 C253 Q254 2.1.1.-,2.1.1.43 27185940 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR 5jiy B 1.48 BS01 III G 1 Y1067 D1074 A1077 D1078 D1083 L1086 F1087 D1088 V1096 C1098 P1121 F1152 Y1154 R1157 F1158 K1162 Y149 D156 A159 D160 D165 L168 F169 D170 V174 C176 P199 F230 Y232 R235 F236 K240 2.1.1.-,2.1.1.43 27185940 EKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRL 5jqp B 2.20 BS01 CA B 1 Q56 D59 S61 D63 D69 E70 Q33 D36 S38 D40 D46 E47 27576940 LPRGVGPEFAKYYTSQGTFTCIGTPSITLSSSQINDNSCDCPDGSDEPGTAACAHLDRLSPEQPLPGSLTGTTNTTSTLPGFWCANEGHIGSYIPFMYVNDGVCDYELCCDGSDEYAHAGGVQCENRCAAI 5jqp B 2.20 BS02 CA B 2 Y121 D124 V126 D128 D137 E138 Y98 D101 V103 D105 D114 E115 27576940 LPRGVGPEFAKYYTSQGTFTCIGTPSITLSSSQINDNSCDCPDGSDEPGTAACAHLDRLSPEQPLPGSLTGTTNTTSTLPGFWCANEGHIGSYIPFMYVNDGVCDYELCCDGSDEYAHAGGVQCENRCAAI 5jrq A 2.29 BS01 6N9 A 1 I463 V471 A481 K483 L505 L514 F516 I527 T529 Q530 W531 C532 S535 H539 F583 G593 D594 F595 G596 I17 V25 A35 K37 L59 L68 F70 I81 T83 Q84 W85 C86 S89 H93 F137 G147 D148 F149 G150 2.7.11.1 27571413 FDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATEKSRSILWMAPEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAR 5jsm A 2.19 BS01 6NB B 1 Q461 I463 V471 A481 K483 L514 F516 T529 Q530 W531 C532 S535 H539 F583 G593 D594 F595 G596 Q17 I19 V27 A37 K39 L70 F72 T85 Q86 W87 C88 S91 H95 F139 G149 D150 F151 G152 2.7.11.1 27571413 SEFDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATEKSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 5jt2 D 2.70 BS01 6NC C 1 Q461 I463 V471 A481 K483 L505 L514 F516 I527 T529 Q530 W531 C532 S535 H539 F583 G593 D594 F595 G596 Q16 I18 V26 A36 K38 L58 L67 F69 I80 T82 Q83 W84 C85 S88 H92 F136 G146 D147 F148 G149 2.7.11.1 27571413 EFDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATESILWMAPEVIRNPYSFQSDVYAFGIVLYELMTGQLPYSSPDLSKVRNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELA 5jvt A 3.10 BS02 NUC C 1 Q282 L283 W321 K325 K327 M330 D333 K334 R337 Y341 Y342 K345 Q4 L5 W43 K47 K49 M52 D55 K56 R59 Y63 Y64 K67 27587584 GQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPT 5jvt G 3.10 BS01 NUC H 1 R337 R340 Y341 Y343 K350 R355 Y356 R59 R62 Y63 Y65 K72 R77 Y78 27587584 GQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQP 5jvt G 3.10 BS02 NUC I 1 Q282 L283 W321 K325 K327 N329 M330 K334 Y341 Y342 Q4 L5 W43 K47 K49 N51 M52 K56 Y63 Y64 27587584 GQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQP 5k0i A 1.30 BS01 6PW A 1 Y130 T131 Q134 Y126 T127 Q130 5.3.99.3 27554445 SLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL 5ke6 A 1.99 BS01 NUC B 1 K409 Y411 K413 H416 R443 E446 R449 K453 F469 R471 H474 K11 Y13 K15 H18 R45 E48 R51 K55 F71 R73 H76 THTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5ke6 A 1.99 BS02 NUC C 1 K413 S415 Y430 R443 S444 D445 R449 F460 S472 D473 K15 S17 Y32 R45 S46 D47 R51 F62 S74 D75 THTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5ke7 A 2.06 BS02 NUC C 1 K413 S415 K418 Y430 R443 S444 D445 R449 S472 D473 K17 S19 K22 Y34 R47 S48 D49 R53 S76 D77 TATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5ke8 A 2.45 BS01 NUC B 1 Y411 T412 K413 H416 W439 F441 R443 D445 P446 R449 H450 K453 R471 H474 Y13 T14 K15 H18 W41 F43 R45 D47 P48 R51 H52 K55 R73 H76 THTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDPLTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5ke8 A 2.45 BS02 NUC C 1 S415 Y430 R443 S444 D445 F460 S472 D473 S17 Y32 R45 S46 D47 F62 S74 D75 THTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDPLTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5ke9 A 2.34 BS01 NUC B 1 K413 H416 W439 F441 R443 P446 R449 H450 K453 R471 H474 K18 H21 W44 F46 R48 P51 R54 H55 K58 R76 H79 RTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDPLTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5ke9 A 2.34 BS02 NUC C 1 S415 Y430 R443 D445 T448 R449 F460 D473 S20 Y35 R48 D50 T53 R54 F65 D78 RTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDPLTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5kea A 2.46 BS01 NUC B 1 K409 Y411 T412 K413 H416 W439 F441 R443 D446 R449 H450 K453 R467 R471 H474 K13 Y15 T16 K17 H20 W43 F45 R47 D50 R53 H54 K57 R71 R75 H78 TATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDDLTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5kea A 2.46 BS02 NUC C 1 K413 S415 Y430 D445 R449 F460 R471 D473 K17 S19 Y34 D49 R53 F64 R75 D77 TATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDDLTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5keb A 2.45 BS01 NUC B 1 K409 Y411 K413 H416 R443 D445 R449 K453 R471 H474 K10 Y12 K14 H17 R44 D46 R50 K54 R72 H75 HTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDDLTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5keb A 2.45 BS02 NUC C 1 K413 S415 K418 Y430 R443 S444 D445 R449 R471 D473 K14 S16 K19 Y31 R44 S45 D46 R50 R72 D74 HTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDDLTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 5khg A 2.24 BS01 CC7 A 1 V564 M572 L574 F580 G581 E582 I583 C584 R591 T592 A593 R632 V122 M130 L132 F138 G139 E140 I141 C142 R149 T150 A151 R190 27568927 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSIL 5khh A 1.77 BS01 6SW A 1 V564 M572 F580 G581 E582 I583 C584 R591 T592 A593 R632 R635 I636 V121 M129 F137 G138 E139 I140 C141 R148 T149 A150 R189 R192 I193 27568927 SSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGK 5khi A 2.10 BS01 6SX A 1 V564 F580 G581 E582 I583 C584 R591 T592 A593 R632 V122 F138 G139 E140 I141 C142 R149 T150 A151 R190 27568927 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSIL 5khy B 3.50 BS01 ZN B 1 E24 K27 E24 K27 27197715 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRG 5kl2 A 1.69 BS01 NUC B 1 K351 R362 F364 R366 Q369 R372 H373 R376 R390 R394 H397 H401 T404 R424 E427 R430 K2 R13 F15 R17 Q20 R23 H24 R27 R41 R45 H48 H52 T55 R75 E78 R81 EKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR 5kl2 A 1.69 BS02 NUC C 1 R366 S367 D368 K371 S395 D396 K399 F411 R424 S425 D426 V429 R17 S18 D19 K22 S46 D47 K50 F62 R75 S76 D77 V80 EKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR 5kl3 A 1.45 BS01 NUC B 1 R362 F364 R366 H369 R372 H373 R376 R390 F392 S393 R394 H397 H401 T404 R424 E427 R430 R12 F14 R16 H19 R22 H23 R26 R40 F42 S43 R44 H47 H51 T54 R74 E77 R80 KPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR 5kl3 A 1.45 BS02 NUC C 1 D368 K371 S395 D396 K399 R424 S425 D426 D18 K21 S45 D46 K49 R74 S75 D76 KPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR 5kl4 A 1.78 BS01 NUC B 1 R362 F364 R366 H369 R372 H373 R376 K381 R390 R394 H397 H401 T404 R424 E427 R430 R15 F17 R19 H22 R25 H26 R29 K34 R43 R47 H50 H54 T57 R77 E80 R83 GSEKPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR 5kl4 A 1.78 BS02 NUC C 1 R366 D368 R372 D396 K399 R424 S425 D426 R19 D21 R25 D49 K52 R77 S78 D79 GSEKPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR 5kl4 A 1.78 BS06 CA A 1 C355 D356 C360 E361 C8 D9 C13 E14 GSEKPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR 5kl4 D 1.78 BS02 NUC F 1 R366 D368 K371 R372 D396 K399 R424 S425 D426 V429 R16 D18 K21 R22 D46 K49 R74 S75 D76 V79 KPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQ 5kl4 D 1.78 BS06 CA D 1 C355 C360 E361 C5 C10 E11 KPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQ 5kl5 A 2.29 BS02 NUC C 1 R366 D368 K371 R372 D396 K399 F411 R424 D426 V429 R18 D20 K23 R24 D48 K51 F63 R76 D78 V81 SEKPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQ 5kl6 A 1.64 BS01 NUC B 1 K351 R362 F364 R366 R369 R372 H373 R376 R390 F392 S393 R394 H397 H401 T404 R424 E427 R430 K1 R12 F14 R16 R19 R22 H23 R26 R40 F42 S43 R44 H47 H51 T54 R74 E77 R80 KPYQCDFKDCERRFSRSDRLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR 5kl6 A 1.64 BS02 NUC C 1 D368 K371 D396 K399 R424 S425 D426 D18 K21 D46 K49 R74 S75 D76 KPYQCDFKDCERRFSRSDRLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR 5kl7 A 1.58 BS01 NUC B 1 R362 F364 R366 R369 R372 H373 R376 R390 R394 H397 H401 T404 R424 E427 R430 R13 F15 R17 R20 R23 H24 R27 R41 R45 H48 H52 T55 R75 E78 R81 EKPYQCDFKDCERRFSRSDRLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQ 5kl7 A 1.58 BS02 NUC C 1 R366 D368 K371 D396 K399 R424 S425 D426 V429 R17 D19 K22 D47 K50 R75 S76 D77 V80 EKPYQCDFKDCERRFSRSDRLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQ 5koj A 2.59 BS01 ICS A 1 V86 R112 H211 Y245 I247 C291 S294 V371 G372 G373 L374 R375 F397 H458 V72 R98 H197 Y231 I233 C277 S280 V357 G358 G359 L360 R361 F383 H444 1.18.6.1 27487256 DKTNDSAFHARLIAEVLEAYPDKARKRRQKHLNVAGQAEGVMLSECDVKSNVKSVPGVMTIRGCAYAGSKGVVWGPVKDMVHISHGPVGCGQYSWSQRRNYYIGNTGVDSFVTMQFTSDFQEKDIVFGGDKKLEKIIDEIDELFPLAKGISVQSECPIGLIGDDIEAVSRKKKKEIGKTIVPVRCEGFRGVSQSLGHHIANDAIRDWVFDGEDKHAAFETTPYDVNVIGDYNIGGDAWSSRILLEEMGLRVVGNWSGDATLAEIERAPKAKLNLIHCYRSMNYICRHMEEKYNIPWTEYNFFGPSQIAASLRKIAALFDEKIQEGAERVIAKYQPLVDAVIEKFRPRLAGKKVMLYVGGLRPRHVVNAYNDLGMEIVGTGYEFGHNDDYQRTGHYVREGTLIYDDVTGYELEKFIEGIRPDLVGSGIKEKYPVQKMGIPFRQMHSWDYSGPYHGYDGFAIFARDMDLAINNPVWSMFKAPW 5koj A 2.59 BS02 CLF A 1 C78 Y80 P101 G103 C104 Y107 E169 C170 G201 C64 Y66 P87 G89 C90 Y93 E155 C156 G187 1.18.6.1 27487256 DKTNDSAFHARLIAEVLEAYPDKARKRRQKHLNVAGQAEGVMLSECDVKSNVKSVPGVMTIRGCAYAGSKGVVWGPVKDMVHISHGPVGCGQYSWSQRRNYYIGNTGVDSFVTMQFTSDFQEKDIVFGGDKKLEKIIDEIDELFPLAKGISVQSECPIGLIGDDIEAVSRKKKKEIGKTIVPVRCEGFRGVSQSLGHHIANDAIRDWVFDGEDKHAAFETTPYDVNVIGDYNIGGDAWSSRILLEEMGLRVVGNWSGDATLAEIERAPKAKLNLIHCYRSMNYICRHMEEKYNIPWTEYNFFGPSQIAASLRKIAALFDEKIQEGAERVIAKYQPLVDAVIEKFRPRLAGKKVMLYVGGLRPRHVVNAYNDLGMEIVGTGYEFGHNDDYQRTGHYVREGTLIYDDVTGYELEKFIEGIRPDLVGSGIKEKYPVQKMGIPFRQMHSWDYSGPYHGYDGFAIFARDMDLAINNPVWSMFKAPW 5koj B 2.59 BS01 CLF A 1 C69 S91 G93 C94 Y97 Y98 T151 C152 A187 C68 S90 G92 C93 Y96 Y97 T150 C151 A186 1.18.6.1 27487256 PQNVDKILDHAPLFREPEYQEMLAGKAKLENMPPADKVVEIADWTKSWEYREKNFARESLSVNPAKACQPLGAVFVASGFERTMSFVHGSQGCVAYYRSHLSRHFKEPSSAVSSSMTEDAAVFGGLNNMVDGLANTYKLYDPKMIAVSTTCMAEVIGDDLHAFIQTAKGKGSVPEEFDVPFAHTPAFVGSHVTGYDNMLKGILEHFWKGRTPVPNRSVNIIPGFDGFAVGNNRELKRILGMMGVQYTILSDVSDQFDTPSDGEYRMYDGGTKIEAARDAVNADYTISLQEYCTPKTLEYCQSFGQKTASFHYPLGIGATDDLLQKLSEISGKPVPQELEMERGRLVDALADSQAYLHGKTYAIYGDPDFVYGMARFILETGGEPKHCLATNGSKAWEAQMQELFDSSPFGVGCKAWGGKDLWHMRSLLATEKVDLLIGNSYGKYLERDTDTPLIRLMFPIFDRHHHHRFPVWGYQGALRVLVTLLDKIFDKLDDDTIQAGVTDYSFDLTR 5koj B 2.59 BS02 FE B 1 D348 D352 D347 D351 1.18.6.1 27487256 PQNVDKILDHAPLFREPEYQEMLAGKAKLENMPPADKVVEIADWTKSWEYREKNFARESLSVNPAKACQPLGAVFVASGFERTMSFVHGSQGCVAYYRSHLSRHFKEPSSAVSSSMTEDAAVFGGLNNMVDGLANTYKLYDPKMIAVSTTCMAEVIGDDLHAFIQTAKGKGSVPEEFDVPFAHTPAFVGSHVTGYDNMLKGILEHFWKGRTPVPNRSVNIIPGFDGFAVGNNRELKRILGMMGVQYTILSDVSDQFDTPSDGEYRMYDGGTKIEAARDAVNADYTISLQEYCTPKTLEYCQSFGQKTASFHYPLGIGATDDLLQKLSEISGKPVPQELEMERGRLVDALADSQAYLHGKTYAIYGDPDFVYGMARFILETGGEPKHCLATNGSKAWEAQMQELFDSSPFGVGCKAWGGKDLWHMRSLLATEKVDLLIGNSYGKYLERDTDTPLIRLMFPIFDRHHHHRFPVWGYQGALRVLVTLLDKIFDKLDDDTIQAGVTDYSFDLTR 5koj B 2.59 BS03 FE D 1 K107 E108 K106 E107 1.18.6.1 27487256 PQNVDKILDHAPLFREPEYQEMLAGKAKLENMPPADKVVEIADWTKSWEYREKNFARESLSVNPAKACQPLGAVFVASGFERTMSFVHGSQGCVAYYRSHLSRHFKEPSSAVSSSMTEDAAVFGGLNNMVDGLANTYKLYDPKMIAVSTTCMAEVIGDDLHAFIQTAKGKGSVPEEFDVPFAHTPAFVGSHVTGYDNMLKGILEHFWKGRTPVPNRSVNIIPGFDGFAVGNNRELKRILGMMGVQYTILSDVSDQFDTPSDGEYRMYDGGTKIEAARDAVNADYTISLQEYCTPKTLEYCQSFGQKTASFHYPLGIGATDDLLQKLSEISGKPVPQELEMERGRLVDALADSQAYLHGKTYAIYGDPDFVYGMARFILETGGEPKHCLATNGSKAWEAQMQELFDSSPFGVGCKAWGGKDLWHMRSLLATEKVDLLIGNSYGKYLERDTDTPLIRLMFPIFDRHHHHRFPVWGYQGALRVLVTLLDKIFDKLDDDTIQAGVTDYSFDLTR 5koj D 2.59 BS02 CLF C 1 C69 P71 S91 G93 C94 Y97 Y98 T151 C152 A187 C68 P70 S90 G92 C93 Y96 Y97 T150 C151 A186 1.18.6.1 27487256 PQNVDKILDHAPLFREPEYQEMLAGKAKLENMPPADKVVEIADWTKSWEYREKNFARESLSVNPAKACQPLGAVFVASGFERTMSFVHGSQGCVAYYRSHLSRHFKEPSSAVSSSMTEDAAVFGGLNNMVDGLANTYKLYDPKMIAVSTTCMAEVIGDDLHAFIQTAKGKGSVPEEFDVPFAHTPAFVGSHVTGYDNMLKGILEHFWKGRTPVPNRSVNIIPGFDGFAVGNNRELKRILGMMGVQYTILSDVSDQFDTPSDGEYRMYDGGTKIEAARDAVNADYTISLQEYCTPKTLEYCQSFGQKTASFHYPLGIGATDDLLQKLSEISGKPVPQELEMERGRLVDALADSQAYLHGKTYAIYGDPDFVYGMARFILETGGEPKHCLATNGSKAWEAQMQELFDSSPFGVGCKAWGGKDLWHMRSLLATEKVDLLIGNSYGKYLERDTDTPLIRLMFPIFDRHHHHRFPVWGYQGALRVLVTLLDKIFDKLDDDTIQAGVTDYSFDLTR 5kqr A 1.33 BS01 SAM A 1 S56 G58 G81 C82 G83 G86 W87 T104 K105 H110 E111 V130 D131 V132 F133 D146 S54 G56 G79 C80 G81 G84 W85 T102 K103 H108 E109 V128 D129 V130 F131 D144 GTGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHAVSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYTKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTRAV 5kqs A 1.50 BS01 M7G A 1 K13 L16 N17 M19 F24 K28 S150 S151 S152 R213 S215 K9 L12 N13 M15 F20 K24 S144 S145 S146 R207 S209 GETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDATGGHAVSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYTKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTRAV 5kqs A 1.50 BS02 SAM A 1 S56 G58 G81 C82 G83 G86 W87 T104 K105 V130 D131 V132 F133 D146 S50 G52 G75 C76 G77 G80 W81 T98 K99 V124 D125 V126 F127 D140 GETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDATGGHAVSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYTKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTRAV 5ku5 A 2.15 BS01 AG A 1 S84 M133 M135 H145 S47 M96 M98 H108 2.7.13.3 27583660 MVKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSQGKTVYHSPGAPDIREFTRDAIPDKDAQGGEVYLLSGPTMMMPGHGHGHMEHSNWRMINLPVGPLVDGKPIYTLYIALSIDFHLHYINDLMN 5ku5 A 2.15 BS02 AG B 1 H42 Q46 H5 Q9 2.7.13.3 27583660 MVKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSQGKTVYHSPGAPDIREFTRDAIPDKDAQGGEVYLLSGPTMMMPGHGHGHMEHSNWRMINLPVGPLVDGKPIYTLYIALSIDFHLHYINDLMN 5ku5 B 2.15 BS02 AG B 2 S84 N85 M133 M135 H145 S46 N47 M95 M97 H107 2.7.13.3 27583660 VKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSQGKTVYHSPGAPDIREFTRDAIPDKDAQGGEVYLLSGPTMMMPGHGHGHMEHSNWRMINLPVGPLVDGKPIYTLYIALSIDFHLHYINDLM 5kub A 1.73 BS01 NUC B 1 Y27 K29 W109 D113 R148 F179 F180 K183 W187 R190 K194 H220 Y29 K31 W111 D115 R150 F181 F182 K185 W189 R192 K196 H222 3.2.2.- 27571247 VPMHPFVKALQEHFTAHQNPEKAEPMARYMKNHFLFLGIQTPERRQLLKDIIQIHTLPDQKDFQIIIRELWDLPEREFQAAALDIMQKYKKHINETHIPFLEELIVTKSWWDSVDSIVPTFLGDIFLKHPELISAYIPKWIASDNIWLQRAAILFQLKYKQKMDEELLFWIIGQLHSSKEFFIQKAIGWVLREYAKTNPDVVWEYVQNNELAPLSKREAIKHIKQNYGINN 5kup A 1.39 BS01 6XL A 1 L408 T410 G411 F413 V416 A428 K430 T474 E475 Y476 M477 A478 G480 L528 D539 L542 S543 V546 Y551 L15 T17 G18 F20 V23 A35 K37 T81 E82 Y83 M84 A85 G87 L135 D146 L149 S150 V153 Y158 2.7.10.2 27571029 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEN 5kvv A 2.01 BS01 NAI A 1 T11 G12 G15 Q16 I17 L42 E43 I44 V88 G89 A90 R91 P92 I109 Q113 T130 G131 N132 L156 L159 H188 A243 T9 G10 G13 Q14 I15 L40 E41 I42 V86 G87 A88 R89 P90 I107 Q111 T128 G129 N130 L154 L157 H186 A241 1.1.1.37 ASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSDLLEANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNRAISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLFHAEVAGKNAAEVVNDQAWIEDEFIPTVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLISSFPVTTKGGNWTIVSGLEIDEFSRGRIDKSTAELADERSAVTELGLI 5kxb A 2.33 BS01 NGA A 1 D117 G135 F159 N161 G244 L245 S246 H249 D87 G105 F129 N131 G214 L215 S216 H219 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENDEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxb A 2.33 BS02 CA A 1 D157 F159 N161 D164 D127 F129 N131 D134 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENDEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxb A 2.33 BS03 MN A 1 E155 D157 D164 H169 E125 D127 D134 H139 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENDEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxb D 2.33 BS01 NGA D 1 D117 G134 G135 F159 N161 G244 L245 S246 H249 D87 G104 G105 F129 N131 G214 L215 S216 H219 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENDEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxc A 1.80 BS01 NAG A 1 R144 N146 S148 R114 N116 S118 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENDEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxc C 1.80 BS01 NAG C 1 H141 R144 N146 S148 H111 R114 N116 S118 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENDEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxc D 1.80 BS01 NAG D 1 R144 N146 N149 R114 N116 N119 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENDEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxc D 1.80 BS02 6Y2 D 1 D117 G135 F159 N161 W163 G244 L245 S246 H249 D87 G105 F129 N131 W133 G214 L215 S216 H219 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENDEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxd D 1.95 BS01 NAG D 1 R144 N146 S148 N149 R114 N116 S118 N119 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENNEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxd D 1.95 BS04 6Y2 D 1 D117 G134 G135 F159 N161 W163 G244 L245 S246 H249 D87 G104 G105 F129 N131 W133 G214 L215 S216 H219 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENNEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5kxe D 2.09 BS01 NAG D 1 N146 S148 N149 N116 S118 N119 KETTSFVFTRFSPDPQNLLLQGDTVVTSSGHLQLTQVKDGEPVYSSLGRALYYAPIHIWDSNTDTVANFVTSFSFVIDAPNKAKAADGLAFFLAPVDTEPQKPGGLLGLFHDDRHNKSNHIVAVEFDTFKNSWDPEGTHIGINVNSIVSRKTISWDLENDEVANVVISYQASTKTLTASLVYPSSSTSYILNDVVDLKQILPEYVRVGFTAASGLSKDHVETHDVLAWTFDSDLPDPS 5l1o A 2.03 BS01 7PF A 1 R74 M77 F232 T236 R240 N283 L285 I286 P287 I387 T388 R73 M76 F231 T235 R239 N282 L284 I285 P286 I386 T387 1.14.19.8 27588339 TDLPRLPFDNPDIMGIAPQMLALQKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALMAGDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPGLAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF 5l1o A 2.03 BS02 HEM A 1 M81 H93 R97 F104 F232 G233 T236 T237 R240 I286 R288 A339 F340 G341 R345 C347 G349 A353 M80 H92 R96 F103 F231 G232 T235 T236 R239 I285 R287 A338 F339 G340 R344 C346 G348 A352 1.14.19.8 27588339 TDLPRLPFDNPDIMGIAPQMLALQKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALMAGDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPGLAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF 5l1p A 2.28 BS01 HEM A 1 M81 H93 R97 F104 L152 G233 T236 T237 R240 L273 R288 A339 F340 G341 R345 C347 G349 A353 M80 H92 R96 F103 L151 G232 T235 T236 R239 L272 R287 A338 F339 G340 R344 C346 G348 A352 1.14.19.8 27588339 TDLPRLPFDNPDIMGIAPQMLALQKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALMAGDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPGLAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF 5l1p A 2.28 BS02 7PT A 1 R74 M77 M81 F232 T236 R240 N283 L285 I286 P287 I387 T388 R73 M76 M80 F231 T235 R239 N282 L284 I285 P286 I386 T387 1.14.19.8 27588339 TDLPRLPFDNPDIMGIAPQMLALQKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALMAGDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPGLAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF 5l1r A 2.00 BS01 HEM A 1 M81 H93 R97 F104 L152 F232 G233 T236 T237 R240 L273 I286 R288 A339 F340 G341 R345 C347 G349 A353 M80 H92 R96 F103 L151 F231 G232 T235 T236 R239 L272 I285 R287 A338 F339 G340 R344 C346 G348 A352 1.14.19.8 27588339 TDLPRLPFDNPDIMGIAPQMLALQKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALMAGDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPGLAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF 5l79 A 2.07 BS06 R47 A 1 G178 G179 L181 A182 H183 T215 H218 E219 H222 H228 P232 K233 A234 V235 F237 P238 T239 Y240 K241 V243 F248 G74 G75 L77 A78 H79 T111 H114 E115 H118 H124 P128 K129 A130 V131 F133 P134 T135 Y136 K137 V139 F144 3.4.24.65 27564088 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5l79 A 2.07 BS07 6PJ A 1 K233 Y240 K241 R249 S251 A252 K129 Y136 K137 R145 S147 A148 3.4.24.65 27564088 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5l7f A 1.80 BS06 6PJ A 1 P232 K233 Y242 V243 R249 S251 A252 P127 K128 Y137 V138 R144 S146 A147 3.4.24.65 27564088 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f A 1.80 BS07 R47 A 1 G178 G179 I180 L181 A182 H183 T215 H218 E219 H222 H228 P232 K233 A234 V235 F237 P238 T239 Y240 A241 Y242 V243 G73 G74 I75 L76 A77 H78 T110 H113 E114 H117 H123 P127 K128 A129 V130 F132 P133 T134 Y135 A136 Y137 V138 3.4.24.65 27564088 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5l7f B 1.80 BS07 6PJ B 1 P232 K233 A241 V243 T247 F248 R249 S251 A252 P127 K128 A136 V138 T142 F143 R144 S146 A147 3.4.24.65 27564088 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYAYVDINTFRLSADDIRGIQSLYG 5ldr A 3.15 BS01 GAL A 1 D134 H302 W327 N364 E365 E446 H450 W489 Y494 H509 D134 H302 W327 N364 E365 E446 H450 W489 Y494 H509 3.2.1.23 MRVTQKLNHGWIFAEGAADPATPLAGETVTLPHNAVDLPLSYFDETSYQRAFTYQRVIAWDDAWQGRRVQLRFDGAMADNVVWVNGVQVVAHPDGYTPFVADLTDHLRPGDNLVTVRIDGSENPAIPPFGAQIDYLTYAGIYRDVWLMVLPERHLTNARILTPDALSDAKTVVIRPEVTAPGPVRARLLDGDREIAATEGEGELTLAGLTGLSLWSTDNPQLYTVELTLPDSGDVTTHRFGFRTAEWTPQGFLLNGQPMKLRGLNRHQSWAHQGYAAGRHAQERDAEIVRHDLCCNMVRTSHYPQSTWFLDRCDEIGLLVFEEIPGWQHIGDQAWQDRSVDNVRAMITRDWNHPSIVIWGVRINESPDNHDFYVRTNALARELDPTRAIGGVRCITDSEMLEDVYTMNDFILDESELPLINRPRTALRPTEEVTGIKKPVPYLVTEYNGHMFPTKAQDPELRQMEHVIRHLEVLNAAHGDPAISGCIGWCMFDYNTHKDFGAGDRICHHGVMDIWREPKFAAHAYGSQKPPSEGIVMEPVTFWARGERNIGGVLPLIVLTNCDEVEFECAGVTRRVGPDRERFPHLPRPPVIIDHRHISAEELGQWGMSWHPGRITGWLNGEQVALREYVADPLPTTLQIAPDRDTLPADGDIDLRVMLRALDQVGNRLPFLDAGIAVTVDGPARLIGPDLRMLQGGTTGMLLRLTGDAGTIRITARHPQFPEAVATVTVG 5ldr A 3.15 BS02 GLC A 1 E568 P612 G613 R614 E568 P612 G613 R614 3.2.1.23 MRVTQKLNHGWIFAEGAADPATPLAGETVTLPHNAVDLPLSYFDETSYQRAFTYQRVIAWDDAWQGRRVQLRFDGAMADNVVWVNGVQVVAHPDGYTPFVADLTDHLRPGDNLVTVRIDGSENPAIPPFGAQIDYLTYAGIYRDVWLMVLPERHLTNARILTPDALSDAKTVVIRPEVTAPGPVRARLLDGDREIAATEGEGELTLAGLTGLSLWSTDNPQLYTVELTLPDSGDVTTHRFGFRTAEWTPQGFLLNGQPMKLRGLNRHQSWAHQGYAAGRHAQERDAEIVRHDLCCNMVRTSHYPQSTWFLDRCDEIGLLVFEEIPGWQHIGDQAWQDRSVDNVRAMITRDWNHPSIVIWGVRINESPDNHDFYVRTNALARELDPTRAIGGVRCITDSEMLEDVYTMNDFILDESELPLINRPRTALRPTEEVTGIKKPVPYLVTEYNGHMFPTKAQDPELRQMEHVIRHLEVLNAAHGDPAISGCIGWCMFDYNTHKDFGAGDRICHHGVMDIWREPKFAAHAYGSQKPPSEGIVMEPVTFWARGERNIGGVLPLIVLTNCDEVEFECAGVTRRVGPDRERFPHLPRPPVIIDHRHISAEELGQWGMSWHPGRITGWLNGEQVALREYVADPLPTTLQIAPDRDTLPADGDIDLRVMLRALDQVGNRLPFLDAGIAVTVDGPARLIGPDLRMLQGGTTGMLLRLTGDAGTIRITARHPQFPEAVATVTVG 5ldr B 3.15 BS01 GAL B 1 D134 H302 W327 E365 F410 E446 H450 W489 Y494 F500 D134 H302 W327 E365 F410 E446 H450 W489 Y494 F500 MRVTQKLNHGWIFAEGAADPATPLAGETVTLPHNAVDLPLSYFDETSYQRAFTYQRVIAWDDAWQGRRVQLRFDGAMADNVVWVNGVQVVAHPDGYTPFVADLTDHLRPGDNLVTVRIDGSENPAIPPFGAQIDYLTYAGIYRDVWLMVLPERHLTNARILTPDALSDAKTVVIRPEVTAPGPVRARLLDGDREIAATEGEGELTLAGLTGLSLWSTDNPQLYTVELTLPDSGDVTTHRFGFRTAEWTPQGFLLNGQPMKLRGLNRHQSWAHQGYAAGRHAQERDAEIVRHDLCCNMVRTSHYPQSTWFLDRCDEIGLLVFEEIPGWQHIGDQAWQDRSVDNVRAMITRDWNHPSIVIWGVRINESPDNHDFYVRTNALARELDPTRAIGGVRCITDSEMLEDVYTMNDFILDESELPLINRPRTALRPTEEVTGIKKPVPYLVTEYNGHMFPTKAQDPELRQMEHVIRHLEVLNAAHGDPAISGCIGWCMFDYNTHKDFGAGDRICHHGVMDIWREPKFAAHAYGSQKPPSEGIVMEPVTFWARGERNIGGVLPLIVLTNCDEVEFECAGVTRRVGPDRERFPHLPRPPVIIDHRHISAEELGQWGMSWHPGRITGWLNGEQVALREYVADPLPTTLQIAPDRDTLPADGDIDLRVMLRALDQVGNRLPFLDAGIAVTVDGPARLIGPDLRMLQGGTTGMLLRLTGDAGTIRITARHPQFPEAVATVTVG 5li1 A 2.00 BS01 III B 1 S264 Y265 L289 E294 D295 W298 D339 M341 M344 Q345 D378 K380 L381 G398 M399 T412 F413 C414 G415 T416 P417 N418 Y419 E445 G449 R450 I455 T466 E467 F556 S19 Y20 L44 E49 D50 W53 D94 M96 M99 Q100 D133 K135 L136 G153 M154 T167 F168 C169 G170 T171 P172 N173 Y174 E200 G204 R205 I210 T211 E212 F301 2.7.11.13 27554858 SFSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDITEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLL 5li1 A 2.00 BS02 ANP A 1 G261 R262 G263 S264 Y265 A266 V268 A281 K283 I332 E333 V335 D339 D382 N383 L385 D396 F552 G16 R17 G18 S19 Y20 A21 V23 A36 K38 I87 E88 V90 D94 D137 N138 L140 D151 F297 2.7.11.13 27554858 SFSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDITEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLL 5li1 A 2.00 BS03 MG A 1 N383 D396 N138 D151 2.7.11.13 27554858 SFSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDITEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLL 5li1 A 2.00 BS04 MG A 2 D292 E294 D295 D47 E49 D50 2.7.11.13 27554858 SFSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDITEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLL 5li9 A 1.79 BS01 ACP A 1 I260 G261 R262 G263 S264 Y265 A266 V268 A281 K283 W298 V316 I332 E333 Y334 V335 D382 D396 F552 I14 G15 R16 G17 S18 Y19 A20 V22 A35 K37 W52 V70 I86 E87 Y88 V89 D136 D150 F294 2.7.11.13 27554858 FSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLL 5lih A 3.25 BS01 III F 1 S264 Y265 W298 D339 M341 Q345 R348 D378 L381 D382 G398 M399 T412 F413 C414 G415 T416 P417 N418 E445 G449 S17 Y18 W44 D85 M87 Q91 R94 D124 L127 D128 G144 M145 T158 F159 C160 G161 T162 P163 N164 E191 G195 2.7.11.13 27554858 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS02 ADP A 1 G261 G263 S264 Y265 A266 V268 A281 K283 I332 E333 V335 D339 D382 N383 L385 T395 D396 F552 G14 G16 S17 Y18 A19 V21 A34 K36 I78 E79 V81 D85 D128 N129 L131 T141 D142 F290 2.7.11.13 27554858 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS03 AF3 A 1 R377 G415 Y419 I420 A421 I424 V434 A438 R123 G161 Y165 I166 A167 I170 V180 A184 2.7.11.13 27554858 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS04 MN A 1 K380 D382 N383 D396 K126 D128 N129 D142 2.7.11.13 27554858 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS05 MN A 2 K283 D396 G398 K36 D142 G144 2.7.11.13 27554858 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih A 3.25 BS06 AF3 A 2 S264 K380 N383 D396 S17 K126 N129 D142 2.7.11.13 27554858 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS01 III G 1 S264 Y265 D339 M341 M344 Q345 D378 D382 G398 M399 T412 F413 C414 G415 T416 P417 E445 G449 R450 S16 Y17 D82 M84 M87 Q88 D121 D125 G141 M142 T155 F156 C157 G158 T159 P160 E188 G192 R193 2.7.11.13 27554858 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS02 ADP B 1 G263 S264 Y265 A266 V268 A281 K283 I332 E333 V335 D339 D382 N383 L385 D396 F552 G15 S16 Y17 A18 V20 A33 K35 I75 E76 V78 D82 D125 N126 L128 D139 F284 2.7.11.13 27554858 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS03 AF3 B 1 R377 D378 Y419 I424 V434 D435 A438 R120 D121 Y162 I167 V177 D178 A181 2.7.11.13 27554858 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS05 MN B 2 D378 D396 D121 D139 2.7.11.13 27554858 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5lih B 3.25 BS06 AF3 B 2 G263 S264 Y265 K380 D396 G15 S16 Y17 K123 D139 2.7.11.13 27554858 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL 5ljx A 1.40 BS01 FUL A 1 F201 G208 L209 S278 F171 G178 L179 S245 TPVWNDNAHGVGSVPMHTDLELDFSLTSSSKYTYRRKLTNPAQSIDLHIEIEEQTIGVDVHALGHWFDGRLNLKTSFKYEYPWHTAKCHYERDYQYEGCTACGLYLDQLKPVGSAYKIITIRYSRRVCVQFGEENLCKIIDMNDCFVSRHVKVCIIGTVSKFSQGDTLLFFGPLEGGGLIFKHWCTSTCQFGDPGDIMSPRDKGFLCPEFPGSFRKKATTPICEYDGNMVSGYKKVMATIDSFQSFNTSTMHFTDERIEWKDPDGMLRDHINILVTKDIDFDNLGENPCKIGLQTSSIEGAWGSGVGFTLTCLVSLTECPTFLTSIKACDKAICYGAESVTLTRGQNTVKVSGKGGHSGSTFRCCHGEDCSQIGLHAAAPHL 5ljz A 1.60 BS01 FUL A 1 F201 L204 G208 L209 S278 F196 L199 G203 L204 S273 TPVWNDNAHGVGSVPMHTDLELDFSLTSSSKYTYRRKLTNPLEEAQSIDLHIEIEEQTIGVDVHALGHWFDGRLNLKTSFHCYGACTKYEYPWHTAKCHYERDYQYETSHGCNPSDCPGVGTGCTACGLYLDQLKPVGSAYKIITIRYSRRVCVQFGEENLCKIIDMNDCFVSRHVKVCIIGTVSKFSQGDTLLFFGPLEGGGLIFKHWCTSTCQFGDPGDIMSPRDKGFLCPEFPGSFRKKCNFATTPICEYDGNMVSGYKKVMATIDSFQSFNTSTMHFTDERIEWKDPDGMLRDHINILVTKDIDFDNLGENPCKIGLQTSSIEGAWGSGVGFTLTCLVSLTECPTFLTSIKACDKAICYGAESVTLTRGQNTVKVSGKGGHSGSTFRCCHGEDCSQIGLHAAAPHL 5lk0 A 1.80 BS01 FUL A 1 F201 L209 F196 L202 TPVWNDNAHGVGSVPMHTDLELDFSLTSSSKYTYRRKLTNPLEEAQSIDLHIEIEEQTIGVDVHALGHWFDGRLNLKTSFHCYGACTKYEYPWHTAKCHYERDYQYETSHGCNPSDCPGVGTGCTACGLYLDQLKPVGSAYKIITIRYSRRVCVQFGEENLCKIIDMNDCFVSRHVKVCIIGTVSKFSQGDTLLFFGPGGGLIFKHWCTSTCQFGDPGDIMSPRDKGFLCPEFPGSFRKKCNFATTPICEYDGNMVSGYKKVMATIDSFQSFNTSTMHFTDERIEWKDPDGMLRDHINILVTKDIDFDNLGENPCKIGLQTSSIEGAWGSGVGFTLTCLVSLTECPTFLTSIKACDKAICYGAESVTLTRGQNTVKVSGKGGHSGSTFRCCHGEDCSQIGLHAAAPHL 5lk1 A 1.70 BS01 FUL A 1 F201 L204 G208 L209 F196 L199 G203 L204 TPVWNDNAHGVGSVPMHTDLELDFSLTSSSKYTYRRKLTNPLEEAQSIDLHIEIEEQTIGVDVHALGHWFDGRLNLKTSFHCYGACTKYEYPWHTAKCHYERDYQYETSHGCNPSDCPGVGTGCTACGLYLDQLKPVGSAYKIITIRYSRRVCVQFGEENLCKIIDMNDCFVSRHVKVCIIGTVSKFSQGDTLLFFGPLEGGGLIFKHWCTSTCQFGDPGDIMSPRDKGFLCPEFPGSFRKKCNFATTPICEYDGNMVSGYKKVMATIDSFQSFNTSTMHFTDERIEWKDPDGMLRDHINILVTKDIDFDNLGENPCKIGLQTSSIEGAWGSGVGFTLTCLVSLTECPTFLTSIKACDKAICYGAESVTLTRGQNTVKVSGKGGHSGSTFRCCHGEDCSQIGLHAAAPHL 5lk2 A 1.60 BS01 FUL A 1 F201 L204 G208 L209 S278 F167 L170 G174 L175 S237 TPVWNDNAHGVGSVPMHTDLELDFSLTSSSKYTYRRKLTNPLEEAQSIDLHIEIEEQTIGVDVHALGHWFDGRLNLKTSFEYPWHTAKCHYERDYTACGLYLDQLKPVGSAYKIITIRYSRRVCVQFGEENLCKIIDMNDCFVSRHVKVCIIGTVSKFSQGDTLLFFGPLEGGGLIFKHWCTSTCQFGDPGDIMSPRDKGFLCPEFPGSFRKKICEYDGNMVSGYKKVMATIDSFQSFNTSTMHFTDERIEWKDPDGMLRDHINILVTKDIDFDNLGENPCKIGLQTSSIEGAWGSGVGFTLTCLVSLTECPTFLTSIKACDKAICYGAESVTLTRGQNTVKVSGKGGHSGSTFRCCHGEDCSQIGLHAAAPHL 5lls A 2.41 BS01 6Z8 A 1 R125 E205 E206 Y547 W629 S630 Y631 W659 Y662 Y666 N710 V711 H740 R86 E166 E167 Y508 W590 S591 Y592 W620 Y623 Y627 N671 V672 H701 3.4.14.5 27438064 RRTYTLTDYLKSTFRVKFYTLQWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNLSSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYLCGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISNEHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLYTLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKYPLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLSKALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP 5lls B 2.41 BS01 6Z8 B 1 R125 E205 E206 F357 Y547 W629 S630 Y631 V656 W659 Y662 Y666 N710 V711 H740 R86 E166 E167 F318 Y508 W590 S591 Y592 V617 W620 Y623 Y627 N671 V672 H701 3.4.14.5 27438064 RRTYTLTDYLKSTFRVKFYTLQWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNLSSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYLCGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISNEHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLYTLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKYPLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLSKALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP 5lls B 2.41 BS02 6Z8 B 2 W187 N279 A280 S281 V282 W148 N240 A241 S242 V243 3.4.14.5 27438064 RRTYTLTDYLKSTFRVKFYTLQWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNLSSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYLCGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISNEHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLYTLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKYPLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLSKALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP 5lma A 1.43 BS01 6ZG A 1 L377 V385 A400 E449 M450 A451 E452 L453 G454 P455 R498 N499 L501 D512 L15 V23 A38 E87 M88 A89 E90 L91 G92 P93 R136 N137 L139 D150 2.7.10.2 27578246 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 5lsm A 2.50 BS01 FMN A 1 A18 P19 M20 A21 N69 F71 H132 Q175 A179 G180 G181 G216 G217 Q236 G238 T239 W323 A16 P17 M18 A19 N67 F69 H123 Q166 A170 G171 G172 G207 G208 Q227 G229 T230 W314 1.13.12.16 CRLTRLFGIEFPIIQAPMAGVQGSALAIAVSEAGGLGSLPCAMLSLEALEAELTAIRSQTAKPINVNFFCHREPVAQAAKQAAWLEQLAPYFAEFNLDPNRTPYSKAQAEVLAKFKPEVVSFHFGLPDEELLLEIKSWGSKVISTATTVEEALWLEARGADAIIAQGLEAGGHRGHFLSEDLTEQLGTFSLLPQIIAAVEIPVIAAGGIVDATTVRAAMTMGASAVQVGTAYLLCPECNTSAIHREALQSDAAQHTALTNLFSGRPARGIVNRFMAEMGPMNEAVPDFPLASSAVAGLRTAAERLGFWDFSPLWCGQNASGCRAIPAADLTRSFVLSLP 5syu B 1.80 BS01 HEM B 1 G104 L105 I107 R108 W111 V239 P241 F261 L274 I275 G278 H279 G282 K283 T284 H285 T323 S324 L326 W330 T388 W420 G69 L70 I72 R73 W76 V204 P206 F226 L239 I240 G243 H244 G247 K248 T249 H250 T288 S289 L291 W295 T353 W385 1.11.1.21 GTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAVKRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDVYWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPQGPDGNPDPVAAARDIRDTFARMAMNDEETVALIAGGHTFGKTHGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGADAITSGLEVTWTTTPTQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKKHRPTMLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARYLGPEVPAEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTAWAAASTFRGSDKRGGANGARIRLAPQKDWEANQPEQLAAVLETLEAIRTAFNGAQRGGKQVSLADLIVLAGCAGVEQAAKNAGHAVTVPFAPGRADASQEQTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDKAQLLTLSAPEMTVLLGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAADADVFEGRDRATGELKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVAVWNKVMNLDRFDLA 5syy A 1.85 BS01 HEM A 1 G104 L105 I107 W111 V239 P241 L274 I275 G278 H279 G282 K283 T284 H285 T323 G324 W330 L386 T388 F416 W420 G69 L70 I72 W76 V204 P206 L239 I240 G243 H244 G247 K248 T249 H250 T288 G289 W295 L351 T353 F381 W385 1.11.1.21 GTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAVKRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDVYWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPEGPDGNPDPVAAARDIRDTFARMAMNDEETVALIAGGHTFGKTHGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGADAITGGLEVTWTTTPTQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKKHRPTMLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARYLGPEVPAEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTAWAAASTFRGSDKRGGANGARIRLAPQKDWEANQPEQLAAVLETLEAIRTAFNGAQRGGKQVSLADLIVLAGCAGVEQAAKNAGHAVTVPFAPGRADASQEQTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDKAQLLTLSAPEMTVLLGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAADADVFEGRDRATGELKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVAVWNKVMNLDRFDLA 5szu A 2.80 BS01 COA A 1 V55 T56 L57 G84 R85 T86 S87 R146 L150 V50 T51 L52 G79 R80 T81 S82 R141 L145 3.1.2.- QLPSHELIMSELMMPDTANFSGNVHGGELLLLLDQVAYSCASRYSGNYCVTLSVDKVLFKEPIHIGDLVTFYAAVNYTGRTSMEIGIEVEAQNIRTGEIRHTNSCYFTMVAVKDGKPVPVPPLEILTDRQRCRYEKAKKRRDISLQA 5szu B 2.80 BS02 COA B 1 V55 T56 L57 G84 R85 T86 S87 V115 P122 R146 S149 L150 V50 T51 L52 G79 R80 T81 S82 V110 P117 R141 S144 L145 3.1.2.- QLPSHELIMSELMMPDTANFSGNVHGGELLLLLDQVAYSCASRYSGNYCVTLSVDKVLFKEPIHIGDLVTFYAAVNYTGRTSMEIGIEVEAQNIRTGEIRHTNSCYFTMVAVKDGKPVPVPPLEILTDRQRCRYEKAKKRRDISLQA 5szu D 2.80 BS02 COA D 2 G31 L34 F64 K65 E66 P67 I68 G26 L29 F59 K60 E61 P62 I63 3.1.2.- QLPSHELIMSELMMPDTANFSGNVHGGELLLLLDQVAYSCASRYSGNYCVTLSVDKVLFKEPIHIGDLVTFYAAVNYTGRTSMEIGIEVEAQNIRTGEIRHTNSCYFTMVAVKDGKPVPVPPLEILTDRQRCRYEKAKKRRDISLQA 5szv A 2.00 BS02 COA B 1 V29 G31 L34 L63 F64 K65 E66 P67 V24 G26 L29 L58 F59 K60 E61 P62 3.1.2.- QLPSHELIMSELMMPDTANFSGNVHGGELLLLLDQVAYSCASRYSGNYCVTLSVDKVLFKEPIHIGDLVTFYAAVNYTGRTSMEIGIRVEAQNIRTGEIRHTNSCYFTMVAVKDGKPVPVPPLEILTDRQRCEYEKAKKRRDISLQA 5szy B 2.00 BS02 COA B 1 V55 T56 L57 G84 R85 T86 S87 P122 R146 S149 V51 T52 L53 G80 R81 T82 S83 P118 R142 S145 3.1.2.- RQLPSHELIMSELMMPDTAAFSGNVHGGELLLLLDQVAYSCASRYSGNYCVTLSVDKVLFKEPIHIGDLVTFYAAVNYTGRTSMEIGIRVEAQNIRTGEIRHTNSCYFTMVAVKDGKPVPVPPLEILTDRQRCRYEKAKKRRDISLQ 5szz C 2.30 BS01 GDP C 1 E11 Y77 A78 A79 N81 G91 I92 R93 H106 S109 Y111 R134 R138 K141 E7 Y73 A74 A75 N77 G87 I88 R89 H102 S105 Y107 R130 R134 K137 3.1.2.- RQLPSHELIMSELMMPDTANFSGNVHGGELLLLLDQVAYSCASRYSGNYCVTLSVDKVLFKEPIHIGDLVTFYAAVNYTGRTSMEIGIRVEAQNIRTGEIRHTNSCYFTMVAVKDGKPVPVPPLEILTDRQRCRYEKAKKRRDISLQA 5szz B 2.30 BS03 COA B 1 V55 T56 L57 G84 R85 T86 S87 R146 S149 V51 T52 L53 G80 R81 T82 S83 R142 S145 3.1.2.- RQLPSHELIMSELMMPDTANFSGNVHGGELLLLLDQVAYSCASRYSGNYCVTLSVDKVLFKEPIHIGDLVTFYAAVNYTGRTSMEIGIRVEAQNIRTGEIRHTNSCYFTMVAVKDGKPVPVPPLEILTDRQRCRYEKAKKRRDISLQA 5t1g A 1.90 BS01 III B 1 I123 G124 A125 T126 F163 R167 I16 G17 A18 T19 F56 R60 EKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERL 5t1i A 1.60 BS01 III C 1 I127 G128 A129 D131 L139 A148 Y168 R171 L172 T173 W174 H175 S176 I19 G20 A21 D23 L31 A40 Y60 R63 L64 T65 W66 H67 S68 GAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHS 5t1i B 1.60 BS01 III C 1 A129 T130 D131 S132 F167 Y168 R171 L172 T173 W174 H175 A21 T22 D23 S24 F59 Y60 R63 L64 T65 W66 H67 GAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHS 5t57 A 1.65 BS01 NAD A 1 G9 G11 G12 K13 M14 E33 V34 A66 V67 P68 D69 I71 I75 L92 D93 H114 F134 G9 G11 G12 K13 M14 E33 V34 A66 V67 P68 D69 I71 I75 L92 D93 H114 F134 MKEKIALFGAGGKMGVRLAKNLLKSDYRVSHVEVSEVGKKRLKDELGLECVSTEAALDNVDVVILAVPDTIIGKIAAQIAPQLRPGTMVMTLDAAAPFAGHLPDRPDLTYFVAHPCHPLIFNDETDPEARRDYFGGGAAKQSITSALMQGPEEAFDLGEAVAKVIYAPILRSYRLTVDQMALLEPGLSETICATLLQVMREAMDETVRRGVPKEAARDFLLGHMNILGAVIFNEIPGAFSDACNKAIEFGKPRLMRDDWIKVFDREEIAESIRRIT 5t57 A 1.65 BS02 CA A 1 D93 E184 E189 D93 E184 E189 MKEKIALFGAGGKMGVRLAKNLLKSDYRVSHVEVSEVGKKRLKDELGLECVSTEAALDNVDVVILAVPDTIIGKIAAQIAPQLRPGTMVMTLDAAAPFAGHLPDRPDLTYFVAHPCHPLIFNDETDPEARRDYFGGGAAKQSITSALMQGPEEAFDLGEAVAKVIYAPILRSYRLTVDQMALLEPGLSETICATLLQVMREAMDETVRRGVPKEAARDFLLGHMNILGAVIFNEIPGAFSDACNKAIEFGKPRLMRDDWIKVFDREEIAESIRRIT 5t57 A 1.65 BS03 ZN A 1 H114 E184 H114 E184 MKEKIALFGAGGKMGVRLAKNLLKSDYRVSHVEVSEVGKKRLKDELGLECVSTEAALDNVDVVILAVPDTIIGKIAAQIAPQLRPGTMVMTLDAAAPFAGHLPDRPDLTYFVAHPCHPLIFNDETDPEARRDYFGGGAAKQSITSALMQGPEEAFDLGEAVAKVIYAPILRSYRLTVDQMALLEPGLSETICATLLQVMREAMDETVRRGVPKEAARDFLLGHMNILGAVIFNEIPGAFSDACNKAIEFGKPRLMRDDWIKVFDREEIAESIRRIT 5t64 A 1.70 BS01 ZN A 1 C13 C16 C54 C57 C5 C8 C46 C49 APARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHEEYPYHSSGSSVMREHFAKVAQRLLATELTGADPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHADEIMAKEQEFRQAGGRWILYVPEVRVL 5t64 A 1.70 BS02 SAH A 1 F72 Y76 S80 F90 I112 G113 N115 F133 E134 P135 S136 F154 F155 A176 N177 T178 H181 I182 Y184 F64 Y68 S72 F82 I104 G105 N107 F125 E126 P127 S128 F146 F147 A168 N169 T170 H173 I174 Y176 APARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHEEYPYHSSGSSVMREHFAKVAQRLLATELTGADPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHADEIMAKEQEFRQAGGRWILYVPEVRVL 5t64 A 1.70 BS03 TMP A 1 Y323 G324 T326 A327 D348 T349 T350 K353 H386 I390 K393 Y315 G316 T318 A319 D340 T341 T342 K345 H378 I382 K385 APARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHEEYPYHSSGSSVMREHFAKVAQRLLATELTGADPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHADEIMAKEQEFRQAGGRWILYVPEVRVL 5t64 B 1.70 BS02 SAH B 1 S80 F90 I112 G113 N115 F133 E134 P135 S136 F154 F155 A176 N177 T178 H181 I182 Y184 S63 F73 I95 G96 N98 F116 E117 P118 S119 F137 F138 A159 N160 T161 H164 I165 Y167 ARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMHSSGSSVMREHFAKVAQRLLATELTGADPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHADEIMAKEQEFRQAGGRWILYVPEVRVL 5t64 B 1.70 BS03 TMP B 1 T326 D348 T349 T350 K353 H386 E389 I390 K393 T309 D331 T332 T333 K336 H369 E372 I373 K376 ARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMHSSGSSVMREHFAKVAQRLLATELTGADPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHADEIMAKEQEFRQAGGRWILYVPEVRVL 5t67 A 1.60 BS03 JHZ A 1 Y76 Y78 N177 H181 Y222 E224 H225 H254 G324 T326 A327 K328 D348 T349 T350 K353 N385 H386 I390 K393 Y67 Y69 N168 H172 Y213 E215 H216 H245 G315 T317 A318 K319 D339 T340 T341 K344 N376 H377 I381 K384 PARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHEEYPYHSSGSSVMREHFAKVAQRLLATELTGADPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHADEIMAKEQEFRQAGGRWILYVPEVRVL 5t67 B 1.60 BS03 JHZ B 1 Y76 Y78 H181 Y222 E224 H225 H254 G324 T326 A327 K328 D348 T349 T350 K353 N385 H386 E389 I390 K393 Y64 Y66 H169 Y210 E212 H213 H242 G312 T314 A315 K316 D336 T337 T338 K341 N373 H374 E377 I378 K381 PARCRVCGDTVDEFLDLGRQPLSDRFLTPDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHEEYPYHSSGSSVMREHFAKVAQRLLATELTGADPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHADEIMAKEQEFRQAGGRWILYVPEVRVL 5t6b A 2.00 BS03 TMP A 1 Y78 Y323 D348 T349 K353 H386 I390 K393 Y70 Y315 D340 T341 K345 H375 I379 K382 APARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHEEYPYHSSGSSVMREHFAMVARDFLATELTGPDPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFAPDYALLFAWNHAEEIMAKEQEFHQAGGRWILYVPEVHIR 5t6b B 2.00 BS02 SAH B 1 F72 Y76 Y78 S80 F90 I112 G113 N115 F133 E134 P135 S136 F154 F155 A176 N177 T178 H181 I182 Y184 F64 Y68 Y70 S72 F82 I104 G105 N107 F125 E126 P127 S128 F146 F147 A168 N169 T170 H173 I174 Y176 APARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHEEYPYHSSGSSVMREHFAMVARDFLATELTGPDPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHAEEIMAKEQEFHQAGGRWILYVPEVHIR 5t6b B 2.00 BS03 TMP B 1 Y323 T326 D348 T349 T350 K353 N385 H386 K393 Y315 T318 D340 T341 T342 K345 N377 H378 K385 APARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHEEYPYHSSGSSVMREHFAMVARDFLATELTGPDPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHAEEIMAKEQEFHQAGGRWILYVPEVHIR 5t6b C 2.00 BS02 SAH C 1 I112 G113 N115 E134 P135 S136 F154 F155 A176 N177 T178 H181 I182 Y184 I92 G93 N95 E114 P115 S116 F134 F135 A156 N157 T158 H161 I162 Y164 ARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHSVMREHFAMVARDFLATELTGPDPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHAEEIMAKEQEFHQAGGRWILYVPEVHIR 5t6b C 2.00 BS03 TMP C 1 K328 D348 T349 T350 K353 N385 H386 I390 K393 K308 D328 T329 T330 K333 N365 H366 I370 K373 ARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFHSVMREHFAMVARDFLATELTGPDPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHAEEIMAKEQEFHQAGGRWILYVPEVHIR 5t6b D 2.00 BS02 SAH D 1 I112 G113 N115 E134 P135 F154 F155 A176 N177 T178 H181 I182 I91 G92 N94 E113 P114 F133 F134 A155 N156 T157 H160 I161 ARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFSVMREHFAMVARDFLATELTGPDPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHAEEIMAKEQEFHQAGGRWILYVPEVHIR 5t6b D 2.00 BS03 TMP D 1 T326 D348 T349 T350 K353 N385 H386 I390 K393 T305 D327 T328 T329 K332 N364 H365 I369 K372 ARCRVCGDTVDEFLDLGRQPLSDRFLTPADTDGEFFYRLAVGRCHACGMVQLTEEVPRHLMFSVMREHFAMVARDFLATELTGPDPFVVEIGCNDGIMLRAVHEAGVRHLGFEPSAGVAEVARSRGVRVRTEFFEKATATAVRESEGPADVIYAANTMCHIPYLESVFQGADALLGPDGVVVFEDPYLGDIVAKTSFDQIYDEHFYLFSAGSVAAMAERFGFELVDVERLPVHGGEVRYTLARRGARTPTEAVGRLLAEEREQGLDDLATLRTFAANVHTVRDELVALLTRLRAEGHRVVGYGATAKSATVTNFCGIGPDLVSFVCDTTPGKQHRLTPGKHLPVRPAEAFADPYPDYALLFAWNHAEEIMAKEQEFHQAGGRWILYVPEVHIR