4zho A 2.34 BS01 FES A 1 Y38 S39 C40 R41 G43 S44 C45 C48 L76 C78 Y37 S38 C39 R40 G42 S43 C44 C47 L75 C77 ATYKVKFITPEGELEVECDDDVYVLDAAEEAGIDLPYSCRAGSCSSCAGKVVSGSVDQSDQSFLDDEQIGEGFVLTCAAYPTSDVTIETHKEEAIML 4zhp A 2.46 BS01 FES A 1 Y38 S39 C40 R41 G43 S44 C45 C48 C78 Y37 S38 C39 R40 G42 S43 C44 C47 C77 ASYKVKLITPDGPIEFECPDDVYILDQAEEEGHDLPYSCRAGSCSSCAGKVTAGTVDQSDGKFLDDDQEAAGFVLTCVAYPKCDVTIETHKEEELTAL 5d9f A 1.91 BS01 58G A 1 L87 S88 P89 Q90 G113 Y115 G117 S132 I133 G134 Y136 L138 G140 G141 P144 L90 S91 P92 Q93 G116 Y118 G120 S135 I136 G137 Y139 L141 G143 G144 P147 2.1.1.228 GSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGDGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHN 5dg5 A 2.60 BS01 5B4 A 1 I1084 V1092 A1108 K1110 E1127 M1131 V1139 L1140 L1157 P1158 Y1159 M1160 K1161 G1163 L1195 F1200 M1211 V1220 A1221 D1222 F1223 Y1234 I35 V43 A59 K61 E78 M82 V90 L91 L108 P109 Y110 M111 K112 G114 L146 F151 M162 V171 A172 D173 F174 Y185 2.7.10.1 26285778 TVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG 5dh3 A 2.47 BS01 5BS A 1 L33 V41 A54 E100 Y101 C102 G103 G105 D109 L153 D164 K298 L15 V23 A36 E82 Y83 C84 G85 G87 D91 L135 D146 K280 2.7.11.1 27535619 LTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQR 5dh3 B 2.47 BS01 5BS B 1 L33 V41 A54 M99 E100 Y101 C102 G105 D109 G150 L153 A163 K298 L16 V24 A37 M82 E83 Y84 C85 G88 D92 G133 L136 A146 K281 2.7.11.1 27535619 SLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRH 5e5u A 2.00 BS01 1PS A 1 W116 E230 F232 W60 E174 F176 3.1.3.48 27539848 DPYWAYSGAYGPEHWVTSSVSCGGSHQSPIDILDHHARVGDEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSVNGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFILRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQALNDRVVSKS 5e5u A 2.00 BS02 1PS A 2 H91 H92 H35 H36 3.1.3.48 27539848 DPYWAYSGAYGPEHWVTSSVSCGGSHQSPIDILDHHARVGDEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSVNGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFILRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQALNDRVVSKS 5e5u C 2.00 BS02 1PS C 2 P58 Y59 Y66 Q292 P2 Y3 Y10 Q236 3.1.3.48 27539848 DPYWAYSGAYGPEHWVTSSVSCGGSHQSPIDILDHHARVGDEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSVNGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFILRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQALNDRVVSKS 5eg1 B 3.42 BS01 ANP A 1 V463 N464 N479 N480 Y481 S482 G483 G484 Q485 A510 V460 N461 N476 N477 Y478 S479 G480 G481 Q482 A507 KQKNSLFNYIYSLMDVRGKFLFFSMLFITSLSSIIISISPLILAKITDLLSGSLSNFSYEYLVLLACLYMFCVISNKASVFLFMILQSSLRINMQKKMSLKYLRELYNENITNLSKNNAGYTTQSLNQASNDIYILVRNVSQNILSPVIQLISTIVVVLSTKDWFSAGVFFLYILVFVIFNTRLTGSLASLRKHSMDITLNSYSLLSDTVDNMIAAKKNNALRLISERYEDALTQENNAQKKYWLLSSKVLLLNSLLAVILFGSVFIYNILGVLNGVVSIGHFIMITSYIILLSTPVENIGALLSEIRQSMSSLAGFIQRHAENKATSPSIPFLNMERKLNLSIRELSFSYSDDKKILNSVSLDLFTGKMYSLTGPSGSGKSTLVKIISGYYKNYFGDIYLNDISLRNISDEDLNDAIYYLTQDDYIFMDTLRFNLRLANYDASENEIFKVLKLANLSVVNNEPVSLDTHLINRGNNYSGGQKQRISLARLFLRKPAIIIIDEATSALDYINESEILSSIRTHFPDALIINISHRINLLECSDCVYVLNEGNIVASGHFRDLMVSNEYISGLASVT 5eg1 B 3.42 BS04 P6L B 1 I155 I158 F174 R186 I152 I155 F171 R183 KQKNSLFNYIYSLMDVRGKFLFFSMLFITSLSSIIISISPLILAKITDLLSGSLSNFSYEYLVLLACLYMFCVISNKASVFLFMILQSSLRINMQKKMSLKYLRELYNENITNLSKNNAGYTTQSLNQASNDIYILVRNVSQNILSPVIQLISTIVVVLSTKDWFSAGVFFLYILVFVIFNTRLTGSLASLRKHSMDITLNSYSLLSDTVDNMIAAKKNNALRLISERYEDALTQENNAQKKYWLLSSKVLLLNSLLAVILFGSVFIYNILGVLNGVVSIGHFIMITSYIILLSTPVENIGALLSEIRQSMSSLAGFIQRHAENKATSPSIPFLNMERKLNLSIRELSFSYSDDKKILNSVSLDLFTGKMYSLTGPSGSGKSTLVKIISGYYKNYFGDIYLNDISLRNISDEDLNDAIYYLTQDDYIFMDTLRFNLRLANYDASENEIFKVLKLANLSVVNNEPVSLDTHLINRGNNYSGGQKQRISLARLFLRKPAIIIIDEATSALDYINESEILSSIRTHFPDALIINISHRINLLECSDCVYVLNEGNIVASGHFRDLMVSNEYISGLASVT 5ega A 2.15 BS03 GK0 A 1 E26 K34 H41 E80 D108 E119 I120 K134 E26 K34 H41 E61 D89 E100 I101 K115 3.1.-.- 27510745 MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSER 5el2 A 1.75 BS01 KBR A 1 L73 L76 H77 L80 A88 M89 M91 G92 K93 L96 W114 L73 L76 H77 L80 A88 M89 M91 G92 K93 L96 W114 27535661 DTTPRRDAEYPPPELLEALKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSSMHDIAMHMGKRCLYPEGETLCDKAFWLHKCWKQSDPKHYFLV 5el2 A 1.75 BS02 KBR A 2 F59 A62 L76 L80 H111 F123 L124 V125 F59 A62 L76 L80 H111 F123 L124 V125 27535661 DTTPRRDAEYPPPELLEALKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSSMHDIAMHMGKRCLYPEGETLCDKAFWLHKCWKQSDPKHYFLV 5el2 A 1.75 BS03 KBR B 1 K93 L96 K93 L96 27535661 DTTPRRDAEYPPPELLEALKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSSMHDIAMHMGKRCLYPEGETLCDKAFWLHKCWKQSDPKHYFLV 5el2 B 1.75 BS02 KBR B 1 E74 L76 H77 A88 M89 G92 K93 L96 W114 E74 L76 H77 A88 M89 G92 K93 L96 W114 27535661 DTTPRRDAEYPPPELLEALKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSSMHDIAMHMGKRCLYPEGETLCDKAFWLHKCWKQSDPKHYFLV 5el2 B 1.75 BS03 KBR B 2 L19 L58 F59 A62 L76 H111 F123 L124 V125 L19 L58 F59 A62 L76 H111 F123 L124 V125 27535661 DTTPRRDAEYPPPELLEALKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSSMHDIAMHMGKRCLYPEGETLCDKAFWLHKCWKQSDPKHYFLV 5f2b A 1.70 BS01 9RU A 1 N23 L25 S27 Y43 S45 A47 G48 K49 W79 A86 S88 T90 W92 W108 L110 S112 R121 L124 D128 N11 L13 S15 Y31 S33 A35 G36 K37 W67 A74 S76 T78 W80 W96 L98 S100 R109 L112 D116 DEAGITGTWYNQLGSTFIVTAGADGALTGTYESAAGKAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGQTEANGWRSTLVGHDTFTKVK 5f35 A 1.60 BS01 SF4 A 1 Y21 C81 P82 M83 N109 C168 V170 E195 C254 Y26 C86 P87 M88 N114 C173 V175 E200 C259 2.5.1.72 HHHHHMVDEILKLKKEKGYIILAHNYQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREYREKFPDAPVVLYVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPECPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG 5f35 A 1.60 BS02 FLC A 1 H19 Y21 D35 S36 Y107 N109 T123 S124 H193 E195 S209 T210 H24 Y26 D40 S41 Y112 N114 T128 S129 H198 E200 S214 T215 2.5.1.72 HHHHHMVDEILKLKKEKGYIILAHNYQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREYREKFPDAPVVLYVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPECPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG 5f3d A 1.90 BS01 SF4 A 1 Y21 C81 N109 C168 V170 E195 C254 Y26 C86 N114 C173 V175 E200 C259 2.5.1.72 HHHHHMVDEILKLKKEKGYIILAHNYQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREYREKFPDAPVVLFVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPECPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG 5f3d A 1.90 BS02 5UK A 1 H19 Y21 D35 S36 M59 F107 N109 T123 S124 H193 E195 T210 H24 Y26 D40 S41 M64 F112 N114 T128 S129 H198 E200 T215 2.5.1.72 HHHHHMVDEILKLKKEKGYIILAHNYQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREYREKFPDAPVVLFVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPECPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG 5fl0 A 1.95 BS01 71I A 1 G135 F136 Y137 K166 D242 D243 C278 Y282 M308 W309 T310 I315 W337 N339 V342 D344 Y345 N372 G132 F133 Y134 K163 D239 D240 C275 Y279 M305 W306 T307 I312 W334 N336 V339 D341 Y342 N369 3.2.1.169 SLQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVKVLKELLSGKQSSKKGMLISIGEKGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTYYALQTFAQLLKDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKNKMNTYIYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAIHPGQDIKWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAELLNYIDEKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKLNPSIQIMWTGDRVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLLLGPVYGNDTTIAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQTWKDAIRTILPSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKEGKNYDKADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTAEMGEEVLKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKTATRVIKPLIDRTFATVVKFFNQKFNAHLDATTDYMPHKMISKNLPLQVKANRVLISPANEVEIELDAIYPGENIQINLEISTDGKEWKTVDLLSAGLQKAPVKFVRFQFVLTIEK 5g36 A 2.60 BS01 RET A 1 W112 T116 M144 G148 Y165 S168 C169 F172 W207 Y210 P211 W214 K242 W93 T97 M125 G129 Y146 S149 C150 F153 W188 Y191 P192 W195 K223 AAAVRENALLSSSLWVNVALAGIAILVFVYMGRTIRPGRPRLIWGATLMIPLVSISSYLGLLSGLTVGMIEMPAGHALAGEMVRSQWGRYLTWALSTPMILLALGLLADVDLGSLFTVIAADIGMCVTGLAAAMTTSALLFRWAFYAISCAFFVVVLSALVTDWAASASSAGTAEIFDTLRVLTVVLWLGYPIVWAVGVEGLALVQSVGVTSWAYSVLDVFAKYVFAFILLRWVANNERTVA 5hca C 2.15 BS01 CA C 1 T21 N54 K55 D323 T8 N41 K42 D228 AKVYFHETFENRDKWIDSTSSGKALGPFKIVSGKWYGDANNKGLQTSEDNKFYIAAAKLDEEFSNKDKNLIVQYNLKFEQGIDCGGGYIKLLPKKSIESEEKFTPESEYNIMFGPDVCGGSKRTHVIMNYKGKNNLIRKEIKCESDDISHLYTLIIRPNNTYVVKIDGVEKQEGKFDEDWDMLAPKEIDDGSGIANPDYVYDPELYKYDSFAYIGIDVWQVKAGTIYDDILITDDIEEAEKEAKVILERNAAEKKMRDEIKEAEN 5hca A 2.15 BS02 BGC A 1 K103 Y122 M125 H138 I140 K91 Y110 M113 H126 I128 SAKVYFHETFENRDKWIDSTSSGKALGPFKIVSGKWYGDANNKGLQTSEDNKFYIAAAKLDEEFSNKDKNLIVQYNLKFEQGIDCGGGYIKLLPKKSIESEEKFTPESEYNIMFGPDVCGGSKRTHVIMNYKGKNNLIRKEIKCESDDISHLYTLIIRPNNTYVVKIDGVEKQEGKFDEDWDMLAPKEIDDGSGIANPDYVYDPELYKYDSFAYIGIDVWQVKAGTIYDDILITDDIEEAEKEAKVILERNAAEKKMRDEIKEAEN 5hcb A 2.90 BS01 CA A 1 T22 N55 K56 D323 D324 R344 T9 N42 K43 D229 D230 R250 SAKVYFHETFENRDKWIDSTSSGKALGPFKIVSGKWYGDANNKGLQTSEDNKFYIAAAKLDEEFSNKDKNLIVQYNLKFEQGIDCGGGYIKLLPKKSIESEEKFTPESEYNIMFGPDVCGGSKRTHVIMNYKGKNNLIRKEIKCESDDISHLYTLIIRPNNTYVVKIDGVEKQEGKFDEDWDMLAPKEIDDGSGIANPDYVYDPELYKYDSFAYIGIDVWQVKAGTIYDDILITDDIEEAEKEAKVILERNAAEKKMRDEIKEAE 5hcf B 2.45 BS01 BGC B 1 F73 Y109 K111 G123 D318 F51 Y87 K89 G101 D214 TVYFHEEFKSMEHWTTSKHRDDFGKVEISAGKFYADAEKSKGLRLTEDARFYALSTAFPTPINNEKKSLVVSFSVKHEQDLKCGGGYIKLLPSMDPEKFHGETKYWLMFGPDRCGSQNRVHIILHYNGENREWSKRIRFPEDKLTHVYTLHIAADNSYEFFLDGESKAKGQLEEDWSLLLPREIVDGSGIPNPDFVEDSELHKVPEPLTHVGIDVWQVESGSIFKDIVIGDDLKEVLDLVEKTYGGLKKAEADALKVMEDMEK 5hcf F 2.45 BS01 BGC F 1 Y109 K111 G123 M130 D318 Y87 K89 G101 M108 D214 TVYFHEEFKSMEHWTTSKHRDDFGKVEISAGKFYADAEKSKGLRLTEDARFYALSTAFPTPINNEKKSLVVSFSVKHEQDLKCGGGYIKLLPSMDPEKFHGETKYWLMFGPDRCGSQNRVHIILHYNGENREWSKRIRFPEDKLTHVYTLHIAADNSYEFFLDGESKAKGQLEEDWSLLLPREIVDGSGIPNPDFVEDSELHKVPEPLTHVGIDVWQVESGSIFKDIVIGDDLKEVLDLVEKTYGGLKKAEADALKVMEDME 5hi3 A 2.15 BS01 III I 1 M23 V24 N25 L26 N27 I28 H29 P59 E60 R61 Y62 L99 R101 F110 M2 V3 N4 L5 N6 I7 H8 P33 E34 R35 Y36 L73 R75 F79 27527709 VMVNLNIHNNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRRENSFRLEKILVSVGCTCVTPIVHHV 5hi3 A 2.15 BS02 63O B 1 P63 E95 I96 L97 K114 P37 E69 I70 L71 K83 27527709 VMVNLNIHNNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRRENSFRLEKILVSVGCTCVTPIVHHV 5hi3 B 2.15 BS01 III I 1 N108 S109 F110 L112 N67 S68 F69 L71 27527709 NPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRRNSFRLEKILVSVGCTCVTPIVH 5hi3 B 2.15 BS02 63O B 1 Y62 P63 I66 E95 I96 L97 L99 L112 Y27 P28 I31 E60 I61 L62 L64 L71 27527709 NPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRRNSFRLEKILVSVGCTCVTPIVH 5hi4 A 1.80 BS02 63P A 1 Y62 P63 I66 W67 E95 I96 L97 V98 L99 L112 Y24 P25 I28 W29 E57 I58 L59 V60 L61 L72 27527709 RSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPPNSFRLEKILVSVGCTCVTPIVH 5hi4 B 1.80 BS01 III I 1 P59 E60 R61 Y62 L99 R101 F110 P24 E25 R26 Y27 L64 R66 F72 27527709 NPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPNSFRLEKILVSVGCTCVTPIVH 5hi4 B 1.80 BS02 63P A 1 P63 I66 E95 I96 L97 V98 K114 P28 I31 E60 I61 L62 V63 K76 27527709 NPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPNSFRLEKILVSVGCTCVTPIVH 5hi5 A 1.80 BS01 III I 1 M23 N25 L26 N27 I28 H29 P59 E60 R61 Y62 L99 F110 M2 N4 L5 N6 I7 H8 P33 E34 R35 Y36 L73 F75 27527709 VMVNLNIHNNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRFRLEKILVSVGCTCVTPIVH 5hi5 A 1.80 BS02 63Q B 1 P63 I66 E95 I96 L97 K114 P37 I40 E69 I70 L71 K79 27527709 VMVNLNIHNNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRFRLEKILVSVGCTCVTPIVH 5hi5 B 1.80 BS01 III I 1 N108 S109 F110 R111 L112 N66 S67 F68 R69 L70 27527709 NPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRNSFRLEKILVSVGCTCVTPIVH 5hi5 B 1.80 BS02 63Q B 1 Y62 P63 V65 I66 W67 E95 I96 L97 L112 Y27 P28 V30 I31 W32 E60 I61 L62 L70 27527709 NPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRNSFRLEKILVSVGCTCVTPIVH 5ihe A 2.50 BS01 D5M A 1 D404 N450 H451 E502 H560 V561 H562 F586 V590 I592 D225 N271 H272 E323 H381 V382 H383 F407 V411 I413 2.7.7.7 VVLDKYGYPILYYSKYEDVVIEWNPSVTPVQIEKNYEVKFDVRQVVEAYASLFKSRLSKLKRILRENPEISNVVDIGKLNYVSGDEEVTIIGLVNSKRETNRGLIFEVEDKTGIVKVFLPKDSEDYREAFKVLPDAVVAFKGFYSKKGIFFANKFYLPDVPLYRKQKPPLEEKVYAILISDIHVGSREFCEKAFLKFLEWLNGHVESKEEEEIVSRVKYLIIAGDVVDGIGIYPGQYSDLVIPDIFDQYEALANLLANVPEHITMFIGPGNHDAARPAIPQPEFYKEYAKPIYKLKNAIIISNPAVIRLHGRDFLIAHGRGIEDVVSFVPGLTHHKPGLPMVELLKMRHLAPTFGGKVPIAPDPEDLLVIEEVPDLVQMGHVHVYDAVVYRGVQLVNSATWQAQTEFQKMVNIVPTPAKVPVVDVESARVVKVLDFSGWC 5ihe A 2.50 BS02 FE A 1 D360 H362 D404 H560 H562 D181 H183 D225 H381 H383 2.7.7.7 VVLDKYGYPILYYSKYEDVVIEWNPSVTPVQIEKNYEVKFDVRQVVEAYASLFKSRLSKLKRILRENPEISNVVDIGKLNYVSGDEEVTIIGLVNSKRETNRGLIFEVEDKTGIVKVFLPKDSEDYREAFKVLPDAVVAFKGFYSKKGIFFANKFYLPDVPLYRKQKPPLEEKVYAILISDIHVGSREFCEKAFLKFLEWLNGHVESKEEEEIVSRVKYLIIAGDVVDGIGIYPGQYSDLVIPDIFDQYEALANLLANVPEHITMFIGPGNHDAARPAIPQPEFYKEYAKPIYKLKNAIIISNPAVIRLHGRDFLIAHGRGIEDVVSFVPGLTHHKPGLPMVELLKMRHLAPTFGGKVPIAPDPEDLLVIEEVPDLVQMGHVHVYDAVVYRGVQLVNSATWQAQTEFQKMVNIVPTPAKVPVVDVESARVVKVLDFSGWC 5ihe A 2.50 BS03 ZN A 1 D404 N450 H497 H560 D225 N271 H318 H381 2.7.7.7 VVLDKYGYPILYYSKYEDVVIEWNPSVTPVQIEKNYEVKFDVRQVVEAYASLFKSRLSKLKRILRENPEISNVVDIGKLNYVSGDEEVTIIGLVNSKRETNRGLIFEVEDKTGIVKVFLPKDSEDYREAFKVLPDAVVAFKGFYSKKGIFFANKFYLPDVPLYRKQKPPLEEKVYAILISDIHVGSREFCEKAFLKFLEWLNGHVESKEEEEIVSRVKYLIIAGDVVDGIGIYPGQYSDLVIPDIFDQYEALANLLANVPEHITMFIGPGNHDAARPAIPQPEFYKEYAKPIYKLKNAIIISNPAVIRLHGRDFLIAHGRGIEDVVSFVPGLTHHKPGLPMVELLKMRHLAPTFGGKVPIAPDPEDLLVIEEVPDLVQMGHVHVYDAVVYRGVQLVNSATWQAQTEFQKMVNIVPTPAKVPVVDVESARVVKVLDFSGWC 5ihe B 2.50 BS01 D5M B 1 H362 D404 N450 H451 E502 H560 V561 F586 I592 H189 D231 N277 H278 E329 H383 V384 F409 I415 2.7.7.7 VVLDKYGYPILYYSKYEDVVIEWNPSVTPVQIEKNYEVKFDVRQVKLRPPKVEAYASLFKSRLSKLKRILRENPEISNVVDIGKLNYVSGDEEVTIIGLVNSKRETNRGLIFEVEDKTGIVKVFLPKDSEDYREAFKVLPDAVVAFKGFYSKKGIFFANKFYLPDVPLYRKQKPPLEEKVYAILISDIHVGSREFCEKAFLKFLEWLNGHVESKEEEEIVSRVKYLIIAGDVVDGIGIYPGQYSDLVIPDIFDQYEALANLLANVPEHITMFIGPGNHDAARPAIPQPEFYKEYAKPIYKLKNAIIISNPAVIRLHGRDFLIAHGRGIEDVVSFVPGKPGLPMVELLKMRHLAPTFGGKVPIAPDPEDLLVIEEVPDLVQMGHVHVYDAVVYRGVQLVNSATWQAQTEFQKMVNIVPTPAKVPVVDVESARVVKVLDFSGWC 5ihe B 2.50 BS04 CA B 1 K238 E544 E550 K65 E367 E373 2.7.7.7 VVLDKYGYPILYYSKYEDVVIEWNPSVTPVQIEKNYEVKFDVRQVKLRPPKVEAYASLFKSRLSKLKRILRENPEISNVVDIGKLNYVSGDEEVTIIGLVNSKRETNRGLIFEVEDKTGIVKVFLPKDSEDYREAFKVLPDAVVAFKGFYSKKGIFFANKFYLPDVPLYRKQKPPLEEKVYAILISDIHVGSREFCEKAFLKFLEWLNGHVESKEEEEIVSRVKYLIIAGDVVDGIGIYPGQYSDLVIPDIFDQYEALANLLANVPEHITMFIGPGNHDAARPAIPQPEFYKEYAKPIYKLKNAIIISNPAVIRLHGRDFLIAHGRGIEDVVSFVPGKPGLPMVELLKMRHLAPTFGGKVPIAPDPEDLLVIEEVPDLVQMGHVHVYDAVVYRGVQLVNSATWQAQTEFQKMVNIVPTPAKVPVVDVESARVVKVLDFSGWC 5ijl A 2.19 BS01 ZN A 1 C706 C709 C718 C721 C623 C626 C635 C638 2.7.7.7,2.7.7.7 PKEMEEYFEMLQREIDKAYEIAKKARAQGKDPSLDVEIPQATDMAGRVESLVGPPGVAKRIRELVKEYGKEIAALKIVDEIIEGKFGDLGSREKYAEQAVRTALAILTEGIVSAPIEGIANVKIKRNTWADNSEYLALYYAGPIRSSGGTAQALSVLVGDYVRRKLGLDRFKPSEKHIERMVEEVDLYHRAVTRLQYHPSPEEVRLAMRNIPIEITGEATDDVEVSHRDVPGVETNQLRGGAILVLAEGVLQKAKKLVKYIDKMGIEGWEWLKEFVEAKEKGVDMGFYYSLYQKFKEEPLFSDPSKPGGFRLRYGRSWGINPATMILVGAVVTPVTTIEGPIVKLKDGSVLRVDDYNLALKVREDVEEILYLGDAVIAFGDQTLLPANYCEEWWILEFVKALKEIYEVHLEPFTENEEESIEEASDYLEIDPEFLKEMLRDPLRVKPPVELAIHFSEVLGIPLHPYYTLYWNSVEPKDVEKLWRLLKNYAEIEWSNFRGIKFAKKIVISQEKLGDSKRTLELLGLPHTVRDGNVIVDYPWAAALLTPLGNLNWEFMAKPLYATIDIINENNEIKLRDRGISWIGKPPVQVLFPIGLAGGSSRDIKKAAEEGKVAEVEIAFFKCPKCGHVGPEHLCPNCGTRKELLWVCPRCNAEYPESQAEGYNYTCPKCNVKLRPYAKRKIRPSELLNRAMENVKVYGVDKLKGVMGMTSGWKMPEPLEKGLLRAKNDVYVFKDGTIRFDATDAPITHFRPREIGVSVEKLRELGYTHDFEGKPLVSEDQIVELKPQDIILSKEAGRYLLKVAKFVDDLLEKFYGLPRFYNAEKMEDLIGHLVIGLAPHTSAGIVGRIIGFVDALVGYAHPYFHAAKRRNCDGDEDAVMLLLDALLNFSRYYLPEKRGGKMDAPLVITTRLDPRYYPLEFYEATYELKSPKELVGVIERVED 5ira A 1.50 BS01 9RU A 1 N23 L25 S27 Y43 S45 V47 G48 N49 W79 A86 S88 T90 W92 W108 L110 S112 D128 N11 L13 S15 Y31 S33 V35 G36 N37 W67 A74 S76 T78 W80 W96 L98 S100 D116 DEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVK 5iwg A 1.66 BS04 CA A 2 F192 T195 V198 Y227 F181 T184 V187 Y216 3.5.1.98 27377864 GKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLP 5j4n A 2.59 BS01 AG2 A 1 N22 I23 A96 C97 W98 G100 N101 M104 S203 I205 W293 N18 I19 A92 C93 W94 G96 N97 M100 S199 I201 W289 ADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVLSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAP 5j7a A 2.30 BS01 RET A 1 W86 T90 L93 M118 W138 S141 T142 W182 Y185 P186 W189 D212 K216 W82 T86 L89 M114 W134 S137 T138 W175 Y178 P179 W182 D205 K209 27545823 TGRPEWIWLALGTALMGLGTLYFLVKGMGVSDPDAKKFYAITTLVPAIAFTMYLSMLLGYGLTMVPFGGEQNPIYWARYADWLFTTPLLLLDLALLVDADQGTILALVGADGIMIGTGLVGALTKVYSYRFVWWAISTAAMLYILYVLFFSKAESMRPEVASTFKVLRNVTVVLWSAYPVVWLIGSEGAGIVPLNIETLLFMVLDVSAKVGFGLILLRSRAIFG 5jpf A 2.40 BS01 III M 1 R261 N294 V295 Y299 W371 E385 R386 V415 Y437 C438 R90 N123 V124 Y128 W200 E214 R215 V244 Y266 C267 3.1.3.16 DIDSLIDKLLNAGFSGKRTKNVCLKNTEIELICASAREIFLSQPSLLELAPPVKVVGDVHGQYHDLIRIFSKCGFPPKTNYLFLGDYVNRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKTWKLFIDTFNTLPIAAIVAGKIFCVHGGLSPVLNSMDEIRNIARPTDVPDFGLLNDLLWSDPADTINEWEDNERGVSYVFSKVAINKFLSKFNFDLVCRAHMVVEDGYEFFNDRTLVTVFSAPNYCDNWGAVMGVSEDLLCSFELLDPL 5jpf A 2.40 BS02 MN A 1 D229 D257 N289 H290 H338 H413 D58 D86 N118 H119 H167 H242 3.1.3.16 DIDSLIDKLLNAGFSGKRTKNVCLKNTEIELICASAREIFLSQPSLLELAPPVKVVGDVHGQYHDLIRIFSKCGFPPKTNYLFLGDYVNRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKTWKLFIDTFNTLPIAAIVAGKIFCVHGGLSPVLNSMDEIRNIARPTDVPDFGLLNDLLWSDPADTINEWEDNERGVSYVFSKVAINKFLSKFNFDLVCRAHMVVEDGYEFFNDRTLVTVFSAPNYCDNWGAVMGVSEDLLCSFELLDPL 5jpf A 2.40 BS03 MN A 2 D229 H231 D257 H290 H413 D58 H60 D86 H119 H242 3.1.3.16 DIDSLIDKLLNAGFSGKRTKNVCLKNTEIELICASAREIFLSQPSLLELAPPVKVVGDVHGQYHDLIRIFSKCGFPPKTNYLFLGDYVNRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKTWKLFIDTFNTLPIAAIVAGKIFCVHGGLSPVLNSMDEIRNIARPTDVPDFGLLNDLLWSDPADTINEWEDNERGVSYVFSKVAINKFLSKFNFDLVCRAHMVVEDGYEFFNDRTLVTVFSAPNYCDNWGAVMGVSEDLLCSFELLDPL 5jqk A 2.35 BS01 MN A 1 D581 H644 S674 E676 E690 D437 H500 S530 E532 E546 27462122 DNNPAARLEELRTIMKKNKIDVYILINSDEHNSEIINEKDKKIVKITNYSGADGILIVTKDKPILYVNALYELQAMNELDQNLFTLRISRIDNRDEIFETISSLFNTIAFDGKNTSVVFYEKLRKALLNAYPKKKIVEKIIYNNNFDDVNVLNFLVLEKSLVEIYPVNNKTLYIHDRKYNGACAGEKIDKLKQSLMYDIKNVDNLLLSELDEIAYLLNLRGYDYQYSPLFYSYLLFQFDREQDFSKIVFFTTVKNLPADVKNLLEINKVIVKEYEEIVPYLRDVVIPSIPKDFKKYDISLSPYINLMIYKLFDRKNVLLQNSPVVKMKAVKNDVEIDNMKQAHILDGLALLQFFHWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPNAAVIHYECTDKTNATIKPAIYLLDSGGQYLHGTTDVTRTTHFGEPTAEEKRIYTLVLKGHLRLRKVIFASYTNSSALDFIARENLFNNFMDYNHGTGHGVGLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYMKDKFGVRIENMQYVISKEITDTTEYLSFDDLTMYPYEKKLLDFSLLTNQEIKELNEYHTTIRNTLLPLVKQSPQEYGESVEKYLIEITEPIAIH 5jqk A 2.35 BS02 MN A 2 F537 D570 D581 T583 E690 F393 D426 D437 T439 E546 27462122 DNNPAARLEELRTIMKKNKIDVYILINSDEHNSEIINEKDKKIVKITNYSGADGILIVTKDKPILYVNALYELQAMNELDQNLFTLRISRIDNRDEIFETISSLFNTIAFDGKNTSVVFYEKLRKALLNAYPKKKIVEKIIYNNNFDDVNVLNFLVLEKSLVEIYPVNNKTLYIHDRKYNGACAGEKIDKLKQSLMYDIKNVDNLLLSELDEIAYLLNLRGYDYQYSPLFYSYLLFQFDREQDFSKIVFFTTVKNLPADVKNLLEINKVIVKEYEEIVPYLRDVVIPSIPKDFKKYDISLSPYINLMIYKLFDRKNVLLQNSPVVKMKAVKNDVEIDNMKQAHILDGLALLQFFHWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPNAAVIHYECTDKTNATIKPAIYLLDSGGQYLHGTTDVTRTTHFGEPTAEEKRIYTLVLKGHLRLRKVIFASYTNSSALDFIARENLFNNFMDYNHGTGHGVGLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYMKDKFGVRIENMQYVISKEITDTTEYLSFDDLTMYPYEKKLLDFSLLTNQEIKELNEYHTTIRNTLLPLVKQSPQEYGESVEKYLIEITEPIAIH 5jqk B 2.35 BS02 MN B 2 F537 D570 D581 T583 E676 E690 F378 D411 D422 T424 E517 E531 27462122 NNPAARLEELRTIMKKNKVYILINSDEHNSEIINEKDKKIVKITNYSGADGILIVTKDKPILYVNALYELQAMNELDQNLFTLRISRIDNRDEIFETIFNTIAFDGKNTSVVFYEKLRKALLNAYPKIVEKIIYNNNFDDVFLVLEKSLVKDYPVNNKTLYIHDRKYNGACAGEKIDKLKQSLMYDIKNVDNLLLSELDEIAYLLNLRGYDYQYSPLFYSYLLFQFDRQDFSKIVFFTTVKNLPADVKNLLEINKVIVKEYEEIVPYLRDVVIPSIDFKKYDISLSPYINLMIYKLFDRKNVLLQNSPVVKMKAVKNDVEIDNMKQAHILDGLALLQFFHWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPNAAVIHYECTDKTNATIKPAIYLLDSGGQYLHGTTDVTRTTHFGEPTAEEKRIYTLVLKGHLRLRKVIFASYTNSSALDFIARENLFNNFMDYNHGTGHGVGLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYMKDKFGVRIENMQYVISKEITDTTEYLSFDDLTMYPYEKKLLDFSLLTNQEIKELNEYHTTIRNTLLPLVKQSPQEYGESVEKYLIEITEPIAI 5jr6 A 2.30 BS01 III F 1 E162 I163 F537 I550 D570 D581 H640 G641 G643 H644 V652 H653 E676 E34 I35 F391 I404 D424 D435 H494 G495 G497 H498 V506 H507 E530 27462122 DNNPAARLEELRTIMKKNKIDVYILINSDEHNSEIINEKDKKIVKITNYSGADGILIVTKDKPILYVNALYELQAMNELDQNLFTLRISRIDNRDEIFETISSLFNTIAFDGKNTSVVFYEKLRKALLNAYPKKKIVEKIIYNNNFDDVLNFLVLEKSLVEIYPVNNKTLYIHDRKYNGACAGEKIDKLKQSLMYDIKNVDNLLLSELDEIAYLLNLRGYDYQYSPLFYSYLLFQFDREQDFSKIVFFTTVKNLPADVKNLLEINKVIVKEYEEIVPYLRDVVIPSIPKDFKKYDISLSPYINLMIYKLFDRKNVLLQNSPVVKMKAVKNDVEIDNMKQAHILDGLALLQFFHWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPNAAVIHYECTDKTNATIKPAIYLLDSGGQYLHGTTDVTRTTHFGEPTAEEKRIYTLVLKGHLRLRKVIFASYTNSSALDFIARENLFNNFMDYNHGTGHGVGLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYMKDKFGVRIENMQYVISKEITDTTEYLSFDDLTMYPYEKKLLDFSLLTNQEIKELNEYHTTIRNTLLPLVKQSPQEYGESVEKYLIEITEPIAI 5jr6 A 2.30 BS02 MN A 1 D581 H644 E676 E690 D435 H498 E530 E544 27462122 DNNPAARLEELRTIMKKNKIDVYILINSDEHNSEIINEKDKKIVKITNYSGADGILIVTKDKPILYVNALYELQAMNELDQNLFTLRISRIDNRDEIFETISSLFNTIAFDGKNTSVVFYEKLRKALLNAYPKKKIVEKIIYNNNFDDVLNFLVLEKSLVEIYPVNNKTLYIHDRKYNGACAGEKIDKLKQSLMYDIKNVDNLLLSELDEIAYLLNLRGYDYQYSPLFYSYLLFQFDREQDFSKIVFFTTVKNLPADVKNLLEINKVIVKEYEEIVPYLRDVVIPSIPKDFKKYDISLSPYINLMIYKLFDRKNVLLQNSPVVKMKAVKNDVEIDNMKQAHILDGLALLQFFHWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPNAAVIHYECTDKTNATIKPAIYLLDSGGQYLHGTTDVTRTTHFGEPTAEEKRIYTLVLKGHLRLRKVIFASYTNSSALDFIARENLFNNFMDYNHGTGHGVGLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYMKDKFGVRIENMQYVISKEITDTTEYLSFDDLTMYPYEKKLLDFSLLTNQEIKELNEYHTTIRNTLLPLVKQSPQEYGESVEKYLIEITEPIAI 5jr6 B 2.30 BS01 MN B 1 D581 H644 S674 E676 E690 D353 H416 S446 E448 E462 27462122 VYILINSDEHNSEIINEKDKKIADGILIVRISRIDNRDEIFETIIAFDGKNTSVVFYEKLRKALLNAYPKIVEKIFLVLEKSLVYPVNNKTLYIHDRKYNGACAGEKIDKLKQSLMYDIKNVDNLLLSELDEIAYLLNLRGYDYQYSPLFYSYLLFQFDRQDFSKIVFFTTVKNLPADVKNLLEINKVIVKEYEEIVPYLRDVVIPSIDFKKYDISLSPYINLMIYKLFDRKNVLLQNSPVVKMKAVKNDVEIDNMKQAHILDGLALLQFFHWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPNAAVIHYECDKTNATIKPAIYLLDSGGQYLHGTTDVTRTTHFGEPTAEEKRIYTLVLKGHLRLRKVIFASYTNSSALDFIARENLFNNFMDYNHGTGHGVGLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYMKDKFGVRIENMQYVISKEITDTTEYLSFDDLTMYPYEKKLLDFSLLTNQEIKELNEYHTTIRNTLLPLVKQSPQEYGESVEKYLIEITEPIA 5jr6 B 2.30 BS02 MN B 2 F537 D570 D581 T583 E690 F310 D342 D353 T355 E462 27462122 VYILINSDEHNSEIINEKDKKIADGILIVRISRIDNRDEIFETIIAFDGKNTSVVFYEKLRKALLNAYPKIVEKIFLVLEKSLVYPVNNKTLYIHDRKYNGACAGEKIDKLKQSLMYDIKNVDNLLLSELDEIAYLLNLRGYDYQYSPLFYSYLLFQFDRQDFSKIVFFTTVKNLPADVKNLLEINKVIVKEYEEIVPYLRDVVIPSIDFKKYDISLSPYINLMIYKLFDRKNVLLQNSPVVKMKAVKNDVEIDNMKQAHILDGLALLQFFHWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPNAAVIHYECDKTNATIKPAIYLLDSGGQYLHGTTDVTRTTHFGEPTAEEKRIYTLVLKGHLRLRKVIFASYTNSSALDFIARENLFNNFMDYNHGTGHGVGLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYMKDKFGVRIENMQYVISKEITDTTEYLSFDDLTMYPYEKKLLDFSLLTNQEIKELNEYHTTIRNTLLPLVKQSPQEYGESVEKYLIEITEPIA 5jrs A 1.97 BS01 6MV A 1 L408 G409 T410 V416 A428 T474 E475 Y476 M477 A478 N479 G480 C481 N484 R487 L528 L14 G15 T16 V22 A34 T80 E81 Y82 M83 A84 N85 G86 C87 N90 R93 L130 2.7.10.2 27531604 MEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMD 5jvo A 1.90 BS01 TYR A 1 P115 A118 S119 D122 T132 I133 A134 P34 A37 S38 D41 T51 I52 A53 27233609 GTREKLRKMLDDLLVSVDHSGNIAVLRTPPGGAPFLASFIDRVGMEEVVGTIAGDDTVFVLARDPMTGQELGEFLSQRR 5jx2 A 2.05 BS01 CA A 1 D71 N73 D75 I77 D166 D59 N61 D63 I65 D154 27536942 RDKPLVFFNRQPSDPGKVDMAAMNWNDKTYYVGFDAKFGGSIQGKMILDFLASSESSVDRNGDGIIGYVLCIGDVGHNDSKVRTEGIRRALGTWTGSSDPGQAKEGQAVVGGKSYKVVELEGKAMTGTDGSTWNTNSATESMGSWVAKFADKIDLVISNNDGMAMGCLQASNYPRGLPIFGYDANADAVESVGKGELTGTVSQNVDAQAVAVLQIIRNLLDGSSGEDVVANGISRPDAHGNKISAPVQYWEDVKAIMADNSEVTSANWKEYTRGARDAGVRQVSAPTKKVLLTVHNASNDFLASAYLPALKHYAPLLNVDLTVVQGDGQNELSCLDKFTNLDMFDAFAVNMVKTNSGADYTDKLKY 5k4p A 1.32 BS01 ZN A 1 E246 T285 D465 H466 E29 T68 D248 H249 2.7.-.- DTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR 5k4p A 1.32 BS02 ZN A 2 T285 H395 T68 H178 2.7.-.- DTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR 5k4p A 1.32 BS03 ZN A 3 Y301 D302 Y84 D85 2.7.-.- DTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR 5k4p A 1.32 BS04 SOR A 1 G282 T283 S284 Y287 G479 M480 P481 N482 G65 T66 S67 Y70 G262 M263 P264 N265 2.7.-.- DTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR 5kao B 1.80 BS01 G43 A 1 R8 L23 D25 G27 A28 D30 V32 G48 G49 I50 V82 I84 R8 L23 D25 G27 A28 D30 V32 G48 G49 I50 V82 I84 PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF 5kb0 A 2.13 BS01 ZN A 1 E31 H35 E31 H35 27532255 EWEALEKKLAALESKCQALEKKLQALEKKHEALEHG 5kb2 A 1.89 BS01 ZN A 1 E31 E34 H35 E31 E34 H35 27532255 EWEALEKKLAAAESKCQALEKKLQALEKKLEALEHG 5kbd A 2.80 BS02 NUC D 1 K138 S139 R268 R300 K27 S28 R157 R189 HEFIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQ 5kbd B 2.80 BS01 NUC C 1 R268 R300 R157 R189 HEFIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQ 5kit A 1.60 BS01 6TA A 1 H191 F193 R196 D219 V242 A244 S275 R311 I351 A379 H174 F176 R179 D202 V225 A227 S258 R294 I334 A362 2.4.2.12 27541271 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 5kit B 1.60 BS01 6TA B 1 H191 F193 R196 D219 V242 A244 S275 I309 R311 A379 H174 F176 R179 D202 V225 A227 S258 I292 R294 A362 2.4.2.12 27541271 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 5kkr B 3.51 BS01 6U7 B 1 V680 A690 R692 F725 T739 S740 L741 C742 F793 T802 D803 F804 V28 A38 R40 F73 T87 S88 L89 C90 F141 T150 D151 F152 2.7.11.1 SQTSIFLQEWDIPFEQLEIGELIGFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQDKLRIQNGWLCHLAPEIIRQLSPDDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLP 5klb A 2.70 BS01 CA B 1 N1225 E1228 N225 E228 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAWVFFIPFIFVVTFVMINLVVAIIVDAMAILNQKEEQHIIDEVQSHEDNINNEIIKLREEIVELKELIKTSLKN 5klg A 3.30 BS01 6UC C 1 I1210 V1213 I210 V213 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAYVFFIPFIFVVTFVMINLVVAIIVD 5klg C 3.30 BS01 6UC C 1 L1176 T1206 M1209 I1210 V1213 L176 T206 M209 I210 V213 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAYVFFIPFIFVVTFVMINLVVAIIVD 5klg C 3.30 BS02 6UC D 1 G1164 F1167 Y1168 G164 F167 Y168 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAYVFFIPFIFVVTFVMINLVVAIIVD 5klg D 3.30 BS01 CA D 1 L1176 D1177 D1178 L176 D177 D178 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAYVFFIPFIFVVTFVMINLVVAIIVD 5klg D 3.30 BS02 6UC D 1 Y1195 I1199 Y195 I199 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAYVFFIPFIFVVTFVMINLVVAIIVD 5kls B 3.30 BS01 CA D 1 D1177 D1178 D177 D178 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAWVFFIPFIFVVTFVMINLVVAIIVD 5kmd D 3.20 BS01 6UB C 1 G1164 F1167 G164 F167 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAYVFFIPFIFVVTFVMINLVVAIIVD 5kmf A 3.20 BS01 6U9 A 1 T1162 G1164 E1165 F1167 Y1168 T162 G164 E165 F167 Y168 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAYVFFIPFIFVVTFVMINLVVAIIVD 5kmh D 3.20 BS01 6U8 C 1 M1174 T1206 M174 T206 MYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLDDWSNGIVRPLMEVYPYAWVFFIPFIFVVTFVMINLVVAIIVD 5kn5 C 2.80 BS01 ZN C 1 H18 H35 H9 H26 27543934 DSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLL 5kp7 A 1.60 BS01 PNS B 1 R33 L37 M39 F163 P166 S167 S216 Y220 F253 M256 R32 L36 M38 F154 P157 S158 S207 Y211 F244 M247 2.3.3.10 QQVGIEALSVYGGAAQLELRKLAQARQLDISRFDNLMMKEKAVSLPYEDPVSYAVNAAKPIIDRLSDADKQRIEMVITCSESGIDFGKSMSTYIQEYLGLSRNCRMFELKQACYSGTAGLQMAINLILSQTFPGAKALVIATDISRFLVYDWSFAEPSSGAGAVALLVSDTPHIFQIDVGCNGYYGYEVMDTCRPNPDSEAGDADLSLLSYLDCCENAYRHYQNRVEGVDYRESFDYLSFHTPFGGMVKGAHRNMMRRLKRAKPAEIEADFQRRVMPGLVYCQQVGNIMGATLFLSLASTIDNGDFSTPRRIGMFSYGSGCCSEFYSGVVTPEGAAIAAQQGISAQLADRYSLSMEEYEQLLYHSSAVAFGTRNVTLDYQLFPGVWKKIAGKGRLVLKAIKEFHRKYEWV 5kp7 B 1.60 BS01 PNS B 1 S39 R42 S39 R42 MSKEQVLKIIKKYTREIAPELEDSPLEPTDSLKKLGIDSVNRAEIIMMVMEDLSLNIPRIELAGAKNIGELADLFAAKL 5kp8 A 1.90 BS01 PNS B 1 R33 L37 M39 F163 P166 S167 A213 S216 P252 F253 M256 N296 R32 L36 M38 F154 P157 S158 A204 S207 P243 F244 M247 N287 2.3.3.10 QQVGIEALSVYGGAAQLELRKLAQARQLDISRFDNLMMKEKAVSLPYEDPVSYAVNAAKPIIDRLSDADKQRIEMVITCSESGIDFGKSMSTYIQEYLGLSRNCRMFELKQASYSGTAGLQMAINLILSQTFPGAKALVIATDISRFLVYDWSFAEPSSGAGAVALLVSDTPHIFQIDVGCNGYYGYEVMDTCRPNPDSEAGDADLSLLSYLDCCENAYRHYQNRVEGVDYRESFDYLSFHTPFGGMVKGAHRNMMRRLKRAKPAEIEADFQRRVMPGLVYCQQVGNIMGATLFLSLASTIDNGDFSTPRRIGMFSYGSGCCSEFYSGVVTPEGAAIAAQQGISAQLADRYSLSMEEYEQLLYHSSAVAFGTRNVTLDYQLFPGVWKKIAGKGRLVLKAIKEFHRKYEWV 5kp8 A 1.90 BS02 6VG B 1 R33 E82 A113 S114 F163 S167 A213 H250 P252 F253 N296 G327 S328 R32 E81 A112 S113 F154 S158 A204 H241 P243 F244 N287 G318 S319 2.3.3.10 QQVGIEALSVYGGAAQLELRKLAQARQLDISRFDNLMMKEKAVSLPYEDPVSYAVNAAKPIIDRLSDADKQRIEMVITCSESGIDFGKSMSTYIQEYLGLSRNCRMFELKQASYSGTAGLQMAINLILSQTFPGAKALVIATDISRFLVYDWSFAEPSSGAGAVALLVSDTPHIFQIDVGCNGYYGYEVMDTCRPNPDSEAGDADLSLLSYLDCCENAYRHYQNRVEGVDYRESFDYLSFHTPFGGMVKGAHRNMMRRLKRAKPAEIEADFQRRVMPGLVYCQQVGNIMGATLFLSLASTIDNGDFSTPRRIGMFSYGSGCCSEFYSGVVTPEGAAIAAQQGISAQLADRYSLSMEEYEQLLYHSSAVAFGTRNVTLDYQLFPGVWKKIAGKGRLVLKAIKEFHRKYEWV 5kp8 B 1.90 BS02 6VG B 1 D38 S39 R42 D38 S39 R42 MSKEQVLKIIKKYTREIAPELEDSPLEPTDSLKKLGIDSVNRAEIIMMVMEDLSLNIPRIELAGAKNIGELADLFAAK 5kpr A 1.83 BS01 ANP A 1 G19 G20 T21 L22 K24 E138 G191 S192 G193 G215 G216 F231 N322 F323 R325 G12 G13 T14 L15 K17 E128 G181 S182 G183 G205 G206 F221 N312 F313 R315 2.7.1.33 VPGSPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNF 5kpt A 2.30 BS01 ANP A 1 G19 G20 T21 L22 K24 G191 S192 G215 G216 F231 G321 N322 F323 R325 G8 G9 T10 L11 K13 G168 S169 G192 G193 F208 G294 N295 F296 R298 2.7.1.33 PWFGMDIGGTLVKLSYFEPIDIEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNF 5kpz A 2.40 BS01 PAZ A 1 G20 E138 S192 G193 V194 S195 R207 G210 T211 G10 E124 S178 G179 V180 S181 R193 G196 T197 2.7.1.33 SPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNF 5kqd A 2.60 BS01 PKZ A 1 G19 G20 L22 K24 G116 G117 N189 G191 S192 G193 V194 S195 R207 G210 T211 N322 G9 G10 L12 K14 G75 G76 N133 G135 S136 G137 V138 S139 R151 G154 T155 N266 2.7.1.33 SPWFGMDIGGTLVKLSYFEPIEQEEVESLKSIRKYLTSNVAYRDVHLELKDLTLFNLHFIRFPTQDLPTFIQMGGGAYKFEKLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPN 5kt2 A 2.49 BS01 NUC T 1 Q84 K85 Y86 L87 V89 N105 V106 R107 E122 L124 P324 Q325 S326 S328 E329 E330 S332 R356 Q34 K35 Y36 L37 V39 N55 V56 R57 E72 L74 P274 Q275 S276 S278 E279 E280 S282 R306 2.7.7.7 SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLGYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK 5kt2 A 2.49 BS02 NUC P 1 E152 K232 G266 I267 G268 Y269 K270 T271 E383 S384 R385 E102 K182 G216 I217 G218 Y219 K220 T221 E328 S329 R330 2.7.7.7 SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLGYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK 5kt3 A 2.64 BS02 NUC P 1 E152 K232 G266 G268 K270 T271 E383 S384 R385 Q386 E102 K182 G216 G218 K220 T221 E327 S328 R329 Q330 2.7.7.7 SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYGRESRQCPIPSHVIQKLYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK 5kt4 A 2.78 BS01 NUC T 1 Q84 K85 Y86 V89 N105 V106 R107 E122 L124 R128 Q325 S326 S328 E329 E330 S332 R356 Q34 K35 Y36 V39 N55 V56 R57 E72 L74 R78 Q275 S276 S278 E279 E280 S282 R306 2.7.7.7 SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEAGKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYGRESRQCPIPSHVIQKLGYDVMTPMVDILMKLFRNMVNVKFHLTLLSVCFCNLK 5kt4 A 2.78 BS02 NUC P 1 D151 E152 K232 P265 G266 I267 G268 Y269 K270 T271 E383 S384 R385 Q386 D101 E102 K182 P215 G216 I217 G218 Y219 K220 T221 E327 S328 R329 Q330 2.7.7.7 SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEAGKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYGRESRQCPIPSHVIQKLGYDVMTPMVDILMKLFRNMVNVKFHLTLLSVCFCNLK 5kt4 A 2.78 BS03 0KX A 1 D59 L60 D61 C62 F63 Y64 V89 T90 K102 D151 K239 D9 L10 D11 C12 F13 Y14 V39 T40 K52 D101 K189 2.7.7.7 SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEAGKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYGRESRQCPIPSHVIQKLGYDVMTPMVDILMKLFRNMVNVKFHLTLLSVCFCNLK 5kt6 A 3.54 BS01 NUC T 1 Q84 K85 Y86 V89 L124 Q325 S326 S328 E329 E330 S332 F333 K334 R356 Q34 K35 Y36 V39 L74 Q275 S276 S278 E279 E280 S282 F283 K284 R306 2.7.7.7 SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLGYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK 5kt6 A 3.54 BS02 NUC P 1 L148 G149 D151 E152 K232 I264 P265 G266 I267 G268 K270 T271 E383 S384 R385 L98 G99 D101 E102 K182 I214 P215 G216 I217 G218 K220 T221 E328 S329 R330 2.7.7.7 SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLGYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK 5kti A 1.80 BS02 6X6 A 1 E135 F198 E69 F132 27542410 AELSCYNSVKNCCPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNLVTVEDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPERK 5l0c A 3.10 BS01 PIO A 1 E976 K979 R1107 E1110 R1128 E18 K21 R149 E152 R170 27503891 NQPVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ 5l0c B 3.10 BS01 PIO B 1 K1012 R1013 T1068 K54 R55 T110 27503891 NQPVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWY 5l0c B 3.10 BS02 PIO B 2 R975 E976 K979 R1107 R1128 R17 E18 K21 R149 R170 27503891 NQPVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWY 5l0c C 3.10 BS01 PIO C 1 E976 K979 W980 R1128 E18 K21 W22 R170 27503891 NQPVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWY 5l0c D 3.10 BS01 PIO D 1 E976 K979 W980 R1107 E1110 R1128 E18 K21 W22 R149 E152 R160 27503891 NQPVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAATLRWVRKTPWYQ 5l0d B 2.75 BS01 PIO B 1 W980 E1110 W21 E151 27503891 QPVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDGFTLRWVRKT 5l0d D 2.75 BS01 PIO D 1 K979 R1107 R1128 K18 R146 R164 27503891 VNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASITDAGFTLRWVRKT 5l0g B 3.40 BS01 PIO B 1 S981 S982 K983 K992 K1129 S23 S24 K25 K34 K169 27503891 NQPVNQPILAAARSLHDEARKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTGFTLRWVRKTPW 5l0h A 2.90 BS01 PIO A 1 W975 K979 K1103 R1107 R1128 W16 K20 K144 R148 R169 27503891 QPVNQPILAAAQSLHWEATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPW 5l3j A 2.83 BS01 6G9 A 1 V43 N46 E50 H55 V71 D73 R76 G77 I78 P79 V120 T165 V167 V29 N32 E36 H41 V57 D59 R62 G63 I64 P65 V88 T133 V135 5.99.1.3 27541007 GLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEYLLENPTDAKIVVGKIIDAARAREAARRAREMT 5l4s A 1.41 BS01 6KX A 1 F108 S182 F184 F235 E238 K242 I273 F104 S178 F180 F231 E234 K238 I269 1.3.1.82 27411040 QRYALVTGANKGIGFEICRQLAEKGIIVILTSRNEKRGLEARQKLLKELNVSENRLVFHQLDVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGVEMVGDVSVFNEYIEADFKALQALEAGAKEEPPFKPKANGEMIEKFEGAKDCVVTNYYGPKRLTQALIPLLQLSPSPRIVNVSSSFGSLLLLWNEWAKGVLGDEDRLTEERVDEVVEVFLKDIKEGKLEESQWPPHFAAERVSKAALNAYTKIAAKKYPSFRINAICPGYAKTDITFHAGPLSVAEAAQVPVKLALLPDGGPSGCFFPRDKALALY 5l4s A 1.41 BS02 NAP A 1 G12 A13 N14 K15 G16 I17 R37 R41 L65 D66 V67 T68 N93 A94 G95 V96 T153 V180 S181 E238 K242 P266 G267 Y268 A269 T271 D272 I273 T274 G8 A9 N10 K11 G12 I13 R33 R37 L61 D62 V63 T64 N89 A90 G91 V92 T149 V176 S177 E234 K238 P262 G263 Y264 A265 T267 D268 I269 T270 1.3.1.82 27411040 QRYALVTGANKGIGFEICRQLAEKGIIVILTSRNEKRGLEARQKLLKELNVSENRLVFHQLDVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGVEMVGDVSVFNEYIEADFKALQALEAGAKEEPPFKPKANGEMIEKFEGAKDCVVTNYYGPKRLTQALIPLLQLSPSPRIVNVSSSFGSLLLLWNEWAKGVLGDEDRLTEERVDEVVEVFLKDIKEGKLEESQWPPHFAAERVSKAALNAYTKIAAKKYPSFRINAICPGYAKTDITFHAGPLSVAEAAQVPVKLALLPDGGPSGCFFPRDKALALY 5l53 A 2.24 BS01 NAP A 1 G20 N22 K23 G24 I25 R45 L74 D75 V76 N102 A103 G104 V186 S187 S188 Y244 K248 P272 G10 N12 K13 G14 I15 R35 L64 D65 V66 N92 A93 G94 V176 S177 S178 Y234 K238 P262 1.1.1.208 27411040 ATKRYAVVTGANKGIGFEICKQLASKGITVILASRDEKRGIEARERLIKELGSEFGDYVVSQQLDVADPASVAALVDFIKTKFGSLDILVNNAGLNGTYMEGDASVLNDYVEAEFKTFQSGAAKTEPYHPKATGRLVETVEHAKECIETNYYGSKRVTEALIPLLQQSDSPRIVNVSSTLSSLVFQTNEWAKGVFSSEEGLTEEKLEEVLAEFLKDFIDGKQQEKQWPPHFSAYKVSKAALNAYTRIIAKKYPSFRINAVCPTDAEAAEAPVKLALLPQGGPSGCFFFRDEAFC 5l89 U 2.59 BS01 CA U 1 R22 D77 R16 D71 STHEPLEVLKEETVNRHRAIVSVMEALEAVDWYDQRVDASTDPELTAILAHNRDEEKEHAAMTLEWLRRNDAKWAEHLRTYLFTEGPITAA 5l89 V 2.59 BS01 CA U 1 D40 R59 K63 D33 R52 K56 THEPLEVLKEETVNRHRAIVSVMEALEAVDWYDQRVDASTDPELTAILAHNRDEEKEHAAMTLEWLRRNDAKWAEHLRTYLFTEGPITA 5l8b c 2.21 BS02 CA a 2 A35 W38 Y39 R42 A29 W32 Y33 R36 STHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEAKEHAAMTLEWLRRNDAKWAEHLRTYLFTEGPIT 5l8g A 2.97 BS03 CA A 3 Y39 E62 Y33 E56 STHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEEKEAAAMTLEWLRRNDAKWAEHLRTYLFTEGPITAA 5l8g B 2.97 BS01 CA B 1 E32 E62 A65 E26 E56 A59 STHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEEKEAAAMTLEWLRRNDAKWAEHLRTYLFTEGPITAA 5l8g F 2.97 BS01 CA F 1 E31 E34 W38 E25 E28 W32 STHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEEKEAAAMTLEWLRRNDAKWAEHLRTYLFTEGPITAA 5l8g K 2.97 BS03 CA T 1 E62 A65 E56 A59 STHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEEKEAAAMTLEWLRRNDAKWAEHLRTYLFTEGPITAA 5l8g T 2.97 BS04 CA T 1 Y39 N58 E62 Y33 N52 E56 STHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEEKEAAAMTLEWLRRNDAKWAEHLRTYLFTEGPITAA 5l8g V 2.97 BS04 CA W 1 Y39 L55 N58 Y33 L49 N52 STHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEEKEAAAMTLEWLRRNDAKWAEHLRTYLFTEGPIT 5l8g W 2.97 BS05 CA W 1 S28 E32 A65 T69 S22 E26 A59 T63 STHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEEKEAAAMTLEWLRRNDAKWAEHLRTYLFTEGPITA 5l8g d 2.97 BS01 CA U 3 E34 W38 E28 W32 STHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEEKEAAAMTLEWLRRNDAKWAEHLRTYLFTEGPITA 5l9b A 1.95 BS01 III C 1 Q239 L240 V241 S242 K244 I251 R252 W258 D277 I280 R281 I292 N293 G294 R295 K297 Y310 R312 H313 V314 D315 P317 N318 R322 R370 W389 F391 R396 K400 Q52 L53 V54 S55 K57 I64 R65 W71 D90 I93 R94 I105 N106 G107 R108 K110 Y123 R125 H126 V127 D128 P130 N131 R135 R183 W202 F204 R209 K213 1.14.11.29 LPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERAAAKVKYLTGEKG 5l9b A 1.95 BS03 AKG A 1 M299 Y310 H313 D315 I327 Y329 L343 H374 V376 R383 M112 Y123 H126 D128 I140 Y142 L156 H187 V189 R196 1.14.11.29 LPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERAAAKVKYLTGEKG 5l9b B 1.95 BS01 III D 1 Q239 L240 V241 S242 K244 S245 I251 R252 W258 D277 I280 N293 G294 R295 K297 Y310 R312 H313 V314 D315 P317 R322 R370 W389 F391 R396 K400 Q52 L53 V54 S55 K57 S58 I64 R65 W71 D90 I93 N106 G107 R108 K110 Y123 R125 H126 V127 D128 P130 R135 R183 W202 F204 R209 K213 1.14.11.29 LPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERAAAKVKYLT 5l9b B 1.95 BS03 AKG B 1 M299 Y310 H313 D315 I327 Y329 H374 V376 R383 M112 Y123 H126 D128 I140 Y142 H187 V189 R196 1.14.11.29 LPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERAAAKVKYLT 5l9r A 1.81 BS03 OGA A 2 V209 D355 I356 R362 V25 D171 I172 R178 1.14.11.29 TKPLPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERAAAKVKYL 5l9v A 1.83 BS01 III C 1 Q239 L240 V241 S242 K244 I251 R252 W258 D277 C281 N284 I292 N293 G294 R295 T296 K297 Y310 V311 R312 H313 V314 D315 C317 N318 R322 R370 W389 Y390 F391 R396 Q51 L52 V53 S54 K56 I63 R64 W70 D89 C93 N96 I104 N105 G106 R107 T108 K109 Y122 V123 R124 H125 V126 D127 C129 N130 R134 R182 W201 Y202 F203 R208 1.14.11.29 PALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLICHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNCNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERAAAKVKY 5la0 A 1.65 BS01 CA A 1 E377 E379 Y420 N509 E337 E339 Y380 N469 27531750 ASSPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTEYAGGGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETATWINNFLTGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la0 A 1.65 BS02 CA A 2 D392 D394 V396 G407 D409 D352 D354 V356 G367 D369 27531750 ASSPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTEYAGGGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETATWINNFLTGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la0 A 1.65 BS04 ARA A 1 E68 N135 G136 N139 N170 F310 V318 E34 N101 G102 N105 N136 F270 V278 27531750 ASSPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTEYAGGGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETATWINNFLTGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la0 A 1.65 BS05 ARA A 2 E411 G423 W424 N507 E371 G383 W384 N467 27531750 ASSPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTEYAGGGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETATWINNFLTGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la1 A 1.90 BS01 XYB A 1 E68 N135 G136 N139 N170 F310 E34 N101 G102 N105 N136 F268 27531750 ASSPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTEYAGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETATWINNFLTGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la2 A 1.65 BS01 AHR A 1 E68 W69 Y92 N135 G136 N139 N170 F310 E32 W33 Y56 N99 G100 N103 N134 F266 27531750 SPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTSYAGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETAGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la2 A 1.65 BS02 XYS A 1 Y92 N139 N170 E171 H253 Y255 S279 F310 Y56 N103 N134 E135 H217 Y219 S243 F266 27531750 SPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTSYAGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETAGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la2 A 1.65 BS03 XYP A 1 G136 N139 G100 N103 27531750 SPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTSYAGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETAGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la2 A 1.65 BS04 XYP A 2 W69 G136 A137 W33 G100 A101 27531750 SPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTSYAGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETAGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la2 A 1.65 BS05 ARB A 1 E411 G423 W424 F478 N507 E359 G371 W372 F426 N455 27531750 SPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTSYAGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETAGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la2 B 1.65 BS01 AHR B 1 E68 W69 N135 G136 N139 N170 F310 E32 W33 N99 G100 N103 N134 F267 27531750 SPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTSYAGGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETAGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la2 B 1.65 BS05 ARB B 1 E411 W424 F478 N507 E360 W373 F427 N456 27531750 SPQRGRPRLNAARTTFVGDNGQPLRGPYTSTEWTAAAPYDQIARVKELGFNAVHLYAECFDPRYPAPGSKAPGYAVNEIDKIVERTRELGLYLVITIGNGANNGNHNAQWARDFWKFYAPRYAKETHVLYEIHNEPVAWGPPYSSSTANPPGAVDMEIDVYRIIRTYAPETPVLLFSYAVFGGKGGAAEALKDIRAFNKAVFGNENAVWTNEAVAFHGYAGWQETTIAVEELLKAGYPCFMTSYAGGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETAGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGYNVGWISEGEWLEYTIRVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPI 5la9 A 2.81 BS01 III C 1 Q239 L240 V241 I251 R252 W258 D277 C281 N284 I292 N293 G294 R295 T296 K297 Y310 V311 R312 H313 C314 D315 P317 R322 R370 P373 W389 Y390 F391 R396 Q52 L53 V54 I55 R56 W62 D81 C85 N88 I96 N97 G98 R99 T100 K101 Y114 V115 R116 H117 C118 D119 P121 R126 R174 P177 W193 Y194 F195 R200 1.14.11.29 LPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVIRGDKITWIEGKEPGCETIGLLMSSMDDLICHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHCDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERAAAKV 5la9 B 2.81 BS03 OGA B 1 Y310 H313 I327 Y329 H374 V376 R383 Y116 H119 I133 Y135 H180 V182 R189 1.14.11.29 LPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVKDIRGDKITWIEGKEPGCETIGLLMSSMDDLICHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHCDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERAAAKVKYLTG 5las A 2.10 BS02 III D 1 K244 S245 S247 S248 D250 I251 V311 K56 S57 S59 S60 D62 I63 V123 1.14.11.29 PALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLICHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNCNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADETAAAKVKY 5lat A 1.90 BS03 BCT A 1 R312 P373 R125 P186 1.14.11.29 LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNRNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLKGVR 5lbb A 1.70 BS03 BCT A 1 R312 V314 P373 R129 V131 P190 1.14.11.29 NGQTLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADETARAKVKYLTGGVRVEL 5lcx A 1.71 BS01 NAP A 1 G12 N14 K15 G16 I17 R37 R41 L65 D66 V67 T68 N93 A94 G95 V96 V180 S181 S182 K242 C265 P266 G267 Y268 A269 T271 D272 I273 T274 G8 N10 K11 G12 I13 R33 R37 L61 D62 V63 T64 N89 A90 G91 V92 V176 S177 S178 K238 C261 P262 G263 Y264 A265 T267 D268 I269 T270 1.3.1.82 27411040 QRYALVTGANKGIGFEICRQLAEKGIIVILTSRNEKRGLEARQKLLKELNVSENRLVFHQLDVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGVEMVGDVSVFNEYIEADFKALQALEAGAKEEPPFKPKANGEMIEKFEGAKDCVVTNYYGPKRLTQALIPLLQLSPSPRIVNVSSSFGSLLLLWNEWAKGVLGDEDRLTEERVDEVVEVFLKDIKEGKLEESQWPPHFAAERVSKAALNAYTKIAAKKYPSFRINAICPGYAKTDITFHAGPLSVAEAAQVPVKLALLPDGGPSGCFFPRDKALALY 5ldg A 1.30 BS02 IT9 A 1 S97 F108 I112 F116 S182 F184 F235 E238 Y268 I273 T274 S93 F104 I108 F112 S178 F180 F231 E234 Y264 I269 T270 1.3.1.82 27411040 QRYALVTGANKGIGFEICRQLAEKGIIVILTSRNEKRGLEARQKLLKELNVSENRLVFHQLDVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGVEMVGDVSVFNEYIEADFKALQALEAGAKEEPPFKPKANGEMIEKFEGAKDCVVTNYYGPKRLTQALIPLLQLSPSPRIVNVSSSFGSLLLLWNEWAKGVLGDEDRLTEERVDEVVEVFLKDIKEGKLEESQWPPHFAAERVSKAALNAYTKIAAKKYPSFRINAICPGYAKTDITFHAGPLSVAEAAQVPVKLALLPDGGPSGCFFPRDKALALY 5lj0 A 1.82 BS01 6XX A 1 V1008 V1013 D1014 V1018 Y1063 N1064 G1070 D1071 I1074 R1077 V30 V35 D36 V40 Y85 N86 G92 D93 I96 R99 3.6.1.3 27530368 SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLCEEIQESR 5lj1 A 1.90 BS01 6XX A 1 W81 P82 F83 V87 L92 L94 N140 D144 W40 P41 F42 V46 L51 L53 N99 D103 27530368 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 5lji A 2.07 BS01 FMN A 1 S10 M11 T12 G13 N14 T15 Y57 T58 Y59 G60 S90 G91 D92 Y95 E97 F98 C99 L125 S9 M10 T11 G12 N13 T14 Y56 T57 Y58 G59 S89 G90 D91 Y94 E96 F97 C98 L124 ALAKIVFASMTGNTEEIADIVADKLRDLGLDVDVDECTTVDASDFLEADIAIVATYTYGDGELPDEMMDFYEDLADLNLNGKIYGVVGSGDTFYDEFCKAVDDFDRVFVSTGAEKGSECVKVDLSAEEEDIERLEQFAEELAAKV 5lji A 2.07 BS02 CA A 1 D34 D36 D33 D35 ALAKIVFASMTGNTEEIADIVADKLRDLGLDVDVDECTTVDASDFLEADIAIVATYTYGDGELPDEMMDFYEDLADLNLNGKIYGVVGSGDTFYDEFCKAVDDFDRVFVSTGAEKGSECVKVDLSAEEEDIERLEQFAEELAAKV 5lji C 2.07 BS03 CA C 2 D61 E63 D60 E62 ALAKIVFASMTGNTEEIADIVADKLRDLGLDVDVDECTTVDASDFLEADIAIVATYTYGDGELPDEMMDFYEDLADLNLNGKIYGVVGSGDTFYDEFCKAVDDFDRVFVSTGAEKGSECVKVDLSAEEEDIERLEQFAEELAAKV 5lk5 G 2.30 BS01 CA G 1 Q26 K62 K64 D328 Q8 K44 K46 D216 PAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQKARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPGSGDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRL 5lpb A 1.98 BS01 ADP A 1 F894 V897 A909 K911 Y956 E957 F958 M959 S963 D966 S1013 L1016 F28 V31 A43 K45 Y90 E91 F92 M93 S97 D100 S144 L147 2.7.10.1,2.7.11.1 24461462 PLRKLAFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDNLVGWVKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQA 5lpv A 2.70 BS03 MN A 2 F894 E923 D1027 F28 E57 D157 2.7.10.1,2.7.11.1 PLRKLAFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPNLVGWVKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQA 5lqc A 1.90 BS01 542 A 1 W38 M40 G66 Y68 E90 M91 Y95 G117 A118 S119 Q120 D141 H142 W143 K144 R146 D169 N170 P174 L198 E199 W35 M37 G63 Y65 E87 M88 Y92 G114 A115 S116 Q117 D138 H139 W140 K141 R143 D166 N167 P171 L195 E196 2.1.1.6 TKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5lqk A 2.24 BS02 72M A 1 W38 M40 G66 Y68 M89 E90 I91 N92 G117 A118 S119 Q120 D141 H142 W143 K144 D169 N170 P174 L198 E199 W37 M39 G65 Y67 M88 E89 I90 N91 G116 A117 S118 Q119 D140 H141 W142 K143 D168 N169 P173 L197 E198 2.1.1.6 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSS 5lqm A 1.62 BS01 SF4 A 1 F21 C81 P82 M83 N109 C168 V170 E195 C254 F26 C86 P87 M88 N114 C173 V175 E200 C259 2.5.1.72 HHHHHMVDEILKLKKEKGYIILAHNFQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREYREKFPDAPVVLYVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPECPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG 5lqs A 1.90 BS02 NTM A 1 H19 F21 S36 Y107 N109 H171 H193 E195 M257 H24 F26 S41 Y112 N114 H176 H198 E200 M262 2.5.1.72 HHHHHMVDEILKLKKEKGYIILAHNFQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREYREKFPDAPVVLYVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPECPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG 5lr6 A 2.30 BS01 731 A 1 M40 G66 Y68 M89 E90 I91 G117 A118 S119 Q120 H142 W143 R146 M39 G64 Y66 M87 E88 I89 G115 A116 S117 Q118 H140 W141 R144 2.1.1.6 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLMKVVDGLEKAIYQGPS 5lr6 B 2.30 BS01 731 B 1 G66 Y68 M89 E90 I91 G117 A118 S119 H142 W143 G62 Y64 M85 E86 I87 G113 A114 S115 H138 W139 2.1.1.6 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 5lr6 D 2.30 BS01 731 D 1 M40 N41 G66 Y68 M89 E90 I91 G117 A118 S119 Q120 H142 W143 M39 N40 G65 Y67 M88 E89 I90 G116 A117 S118 Q119 H141 W142 2.1.1.6 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGP 5svz A 2.00 BS01 III B 1 L104 S105 R106 E107 K108 P110 F138 W142 N146 A148 S149 G150 T151 S152 T155 Q181 W184 N188 G191 D192 N228 W231 N235 R238 Y277 L33 S34 R35 E36 K37 P39 F67 W71 N75 A77 S78 G79 T80 S81 T84 Q110 W113 N117 G120 D121 N157 W160 N164 R167 Y206 GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFS 5sw7 B 1.85 BS01 HEM B 1 T38 F41 F42 H63 K66 A70 F71 L88 L91 H92 L96 V98 N102 F103 L106 V137 L141 T38 F41 F42 H63 K66 A70 F71 L88 L91 H92 L96 V98 N102 F103 L106 V137 L141 MHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLDGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH 5sx3 A 2.00 BS01 HEM A 1 G104 L105 I107 R108 W111 V239 P241 F261 L274 I275 G278 H279 G282 K283 T284 H285 T323 S324 W330 F416 W420 G69 L70 I72 R73 W76 V204 P206 F226 L239 I240 G243 H244 G247 K248 T249 H250 T288 S289 W295 F381 W385 1.11.1.21 16618106 GTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAVKRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDVYWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPEGPDGNPDPVAAARDIRDTFARMAMNDEETVALIAGGHTFGKTHGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGADAITSGLEVTWTTTPTQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKKHRPTMLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARYLGPEVPAEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTAWAAASTFRGSDKRGGANGARIRLAPQKDWEANQPEQLAAVLETLEAIRTAFNGAQRGGKQVSLADLIVLAGCAGVEQAAKNAGHAVTVPFAPGRADASQEQTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDKAQLLTLSAPEMTVLLGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAADADVFEGRDRATGELKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVAVWNKVMNLDRFDLA 5sx6 B 1.90 BS02 OXY B 1 R108 W111 H112 D141 R73 W76 H77 D106 1.11.1.21 16618106 GTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAVKRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDVYWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPEGPDGNPDPVAAARDIRDTFARMAMNDEETVALIAGGHTFGKTHGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGADAITSGLEVTWTTTPTQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKKHRPTMLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARYLGPEVPAEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTAWAAASTFRGSDKRGGANGARIRLAPQKDWEANQPEQLAAVLETLEAIRTAFNGAQRGGKQVSLADLIVLAGCAGVEQAAKNAGHAVTVPFAPGRADASQEQTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDKAQLLTLSAPEMTVLLGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAADADVFEGRDRATGELKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVAVWNKVMNLDRFDLA 5t0t A 2.20 BS01 72Q A 1 F244 S246 H248 M252 F254 A277 F280 Y281 M289 S292 H293 L296 V302 S304 Y307 M309 L319 T321 I337 C339 N341 F6 S8 H10 M14 F16 A39 F42 Y43 M51 S54 H55 L58 V64 S66 Y69 M71 L81 T83 I95 C97 N99 LDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPPQCIMCVNYVLSE