4rfr B 1.50 BS01 RHN B 1 N120 Y122 L128 H131 D133 I143 S145 F154 W178 H187 I189 R204 N206 T208 R210 N107 Y109 L115 H118 D120 I130 S132 F141 W165 H174 I176 R191 N193 T195 R197 1.14.11.33 PLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGK 4rfr B 1.50 BS02 MN B 1 H131 D133 H187 H118 D120 H174 1.14.11.33 PLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGK 4x09 A 1.72 BS01 SO4 A 1 Q14 H15 H122 L123 Q15 H16 H123 L124 3.1.27.5 27013146 MWPKRLTKAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFLHDSFQNVAAVCDLLSIVCKNRRHNCHQSSKPVNMTDCRLTSGKYPQCRYSAAAQYKFFIVACDPPQKSDPPYKLVPVHLDSIL 4xet A 1.30 BS01 FE A 1 H86 H88 C93 H140 H83 H85 C90 H137 1.13.11.20 TELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLFSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTP 4xf1 A 1.55 BS01 FE A 1 H86 H88 H140 H82 H84 H136 1.13.11.20 ELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLFSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTP 4xf1 A 1.55 BS02 CYS A 1 Y58 R60 L75 H86 H88 H140 V142 H155 F157 M179 Y54 R56 L71 H82 H84 H136 V138 H151 F153 M175 1.13.11.20 ELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLFSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTP 4xf3 A 1.55 BS01 FE A 1 H86 H88 H140 H82 H84 H136 1.13.11.20 ELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLFSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTP 4xf3 A 1.55 BS02 CYS A 1 Y58 R60 L75 H86 H88 H140 V142 H155 F157 M179 Y54 R56 L71 H82 H84 H136 V138 H151 F153 M175 1.13.11.20 ELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLFSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTP 4xqj A 1.90 BS01 NUC B 1 S164 H169 N185 L186 K187 R198 N201 S202 S25 H30 N46 L47 K48 R59 N62 S63 VETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xqj A 1.90 BS02 NUC C 1 G148 S168 H169 R170 Y183 H200 N201 R218 S231 V232 R233 G9 S29 H30 R31 Y44 H61 N62 R79 S92 V93 R94 VETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xqj D 1.90 BS01 NUC E 1 S164 H169 N185 L186 K187 R198 N201 S202 S25 H30 N46 L47 K48 R59 N62 S63 VETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKK 4xqj D 1.90 BS02 NUC F 1 R147 G148 S168 H169 R170 Y183 H200 N201 R218 S231 V232 R233 R8 G9 S29 H30 R31 Y44 H61 N62 R79 S92 V93 R94 VETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKK 4xqn A 2.30 BS01 NUC B 1 S164 H169 N185 L186 K187 R198 N201 S202 S24 H29 N45 L46 K47 R58 N61 S62 ETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKK 4xqn A 2.30 BS02 NUC C 1 G148 S168 H169 R170 Y183 H200 N201 R218 S231 V232 R233 G8 S28 H29 R30 Y43 H60 N61 R78 S91 V92 R93 ETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKK 4xqn D 2.30 BS01 NUC E 1 S164 H169 N185 L186 K187 R198 N201 S202 S24 H29 N45 L46 K47 R58 N61 S62 ETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xqn D 2.30 BS02 NUC F 1 G148 S168 H169 R170 Y183 H200 N201 R218 S231 V232 R233 G8 S28 H29 R30 Y43 H60 N61 R78 S91 V92 R93 ETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xqn G 2.30 BS01 NUC H 1 S164 H169 N185 L186 K187 R198 N201 S202 R233 S24 H29 N45 L46 K47 R58 N61 S62 R93 ETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xqn G 2.30 BS02 NUC I 1 G148 S168 H169 R170 Y183 H200 N201 R218 S231 V232 R233 G8 S28 H29 R30 Y43 H60 N61 R78 S91 V92 R93 ETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xqn J 2.30 BS01 NUC K 1 S164 H169 N185 L186 K187 R198 N201 S202 S24 H29 N45 L46 K47 R58 N61 S62 ETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xqn J 2.30 BS02 NUC L 1 S168 H169 R170 Y183 H200 N201 R218 S231 V232 R233 S28 H29 R30 Y43 H60 N61 R78 S91 V92 R93 ETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xxe A 3.20 BS01 NUC B 1 S164 H169 N185 L186 K187 N201 S202 S25 H30 N46 L47 K48 N62 S63 VETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xxe A 3.20 BS02 NUC C 1 G148 S168 H169 R170 Y183 H200 N201 R218 S231 V232 R233 N234 G9 S29 H30 R31 Y44 H61 N62 R79 S92 V93 R94 N95 VETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xxe D 3.20 BS01 NUC E 1 S164 H169 N185 L186 K187 R198 N201 S202 S25 H30 N46 L47 K48 R59 N62 S63 VETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xxe D 3.20 BS02 NUC F 1 G148 S168 H169 R170 Y183 H200 N201 R218 S231 V232 R233 G9 S29 H30 R31 Y44 H61 N62 R79 S92 V93 R94 VETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xyq A 2.40 BS01 NUC B 1 S164 H169 N185 L186 K187 R198 N201 S202 S29 H34 N50 L51 K52 R63 N66 S67 MDNSVETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4xyq A 2.40 BS02 NUC C 1 G148 R170 Y183 H200 N201 R218 S231 V232 R233 G13 R35 Y48 H65 N66 R83 S96 V97 R98 MDNSVETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI 4y1u B 1.76 BS01 GAL B 1 H44 N46 R48 N61 E71 H43 N45 R47 N60 E70 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1u B 1.76 BS02 MAG B 1 R48 H52 E71 R73 R47 H51 E70 R72 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1u A 1.76 BS01 GAL A 1 H44 N46 R48 N61 W68 E71 H43 N45 R47 N60 W67 E70 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1u A 1.76 BS02 MAG A 1 R48 E71 R73 R47 E70 R72 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1v A 2.32 BS01 MAG A 1 R48 E71 R73 R47 E70 R72 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1v A 2.32 BS02 GAL A 1 H44 R48 N61 W68 E71 H43 R47 N60 W67 E70 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1v B 2.32 BS01 MAG B 1 R48 E71 R73 R47 E70 R72 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1v B 2.32 BS02 GAL B 1 H44 R48 N61 E71 H43 R47 N60 E70 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1x A 2.45 BS01 GAL A 1 H44 R48 H52 N61 W68 E71 H43 R47 H51 N60 W67 E70 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1x A 2.45 BS02 6S2 A 1 R48 W68 E71 R73 R47 W67 E70 R72 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1x B 2.45 BS01 GAL B 1 H44 N46 R48 H52 N61 E71 H43 N45 R47 H51 N60 E70 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1x B 2.45 BS02 6S2 B 1 R48 D54 E71 R73 R47 D53 E70 R72 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1y A 1.86 BS01 GAL A 1 H44 N46 R48 H52 N61 W68 E71 H42 N44 R46 H50 N59 W66 E69 GLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAF 4y1y A 1.86 BS02 6S2 A 1 R48 H52 E71 R73 R46 H50 E69 R71 GLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAF 4y1y B 1.86 BS01 GAL B 1 H44 N46 R48 H52 N61 E71 H42 N44 R46 H50 N59 E69 GLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAF 4y1y B 1.86 BS02 6S2 B 1 R48 E71 R73 R46 E69 R71 GLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAF 4y1z A 2.23 BS01 GAL A 1 H44 N46 R48 N61 W68 E71 H42 N44 R46 N59 W66 E69 GLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1z A 2.23 BS02 6C2 A 1 R48 E71 R73 R46 E69 R71 GLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1z B 2.23 BS01 GAL B 1 H44 R48 H52 N61 W68 E71 H43 R47 H51 N60 W67 E70 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y1z B 2.23 BS02 6C2 B 1 R48 H52 D54 E71 R73 R47 H51 D53 E70 R72 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y20 A 2.20 BS01 SLT A 1 H44 N46 R48 H52 N61 W68 E71 R73 D123 H43 N45 R47 H51 N60 W67 E70 R72 D122 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y20 B 2.20 BS01 SLT B 1 H44 N46 R48 N61 W68 E71 R73 H43 N45 R47 N60 W67 E70 R72 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y22 B 2.50 BS01 SGA B 1 H44 R48 H52 N61 E71 H43 R47 H51 N60 E70 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y22 B 2.50 BS02 MAG B 1 R48 H52 E71 R73 R47 H51 E70 R72 CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD 4y26 A 2.61 BS01 GAL A 1 H49 R53 N62 W69 E72 H47 R51 N60 W67 E70 VPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVVGDAQYHHFRHRLPLARVRLVEVGGDVQLDSVRIF 4y26 A 2.61 BS02 6S2 A 1 R53 E72 R74 R51 E70 R72 VPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVVGDAQYHHFRHRLPLARVRLVEVGGDVQLDSVRIF 4y26 B 2.61 BS01 GAL B 1 H49 N51 R53 N62 W69 E72 H47 N49 R51 N60 W67 E70 VPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVVGDAQYHHFRHRLPLARVRLVEVGGDVQLDSVRIF 4y26 B 2.61 BS02 6S2 B 1 R53 E72 R74 R51 E70 R72 VPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVVGDAQYHHFRHRLPLARVRLVEVGGDVQLDSVRIF 4ygb B 1.60 BS01 CA B 1 D81 D83 N85 L87 E92 D13 D15 N17 L19 E24 PQELQLHYFKMHDYDGNNLLDGLELSTAITLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygb B 1.60 BS02 CA B 2 D129 N131 D133 Y135 E140 D49 N51 D53 Y55 E60 PQELQLHYFKMHDYDGNNLLDGLELSTAITLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygb D 1.60 BS01 CA D 1 D81 D83 N85 L87 E92 D13 D15 N17 L19 E24 PQELQLHYFKMHDYDGNNLLDGLELSTAITLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygb D 1.60 BS02 CA D 2 D129 N131 D133 Y135 E140 D49 N51 D53 Y55 E60 PQELQLHYFKMHDYDGNNLLDGLELSTAITLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygc A 2.40 BS01 CA A 1 D152 F154 N156 D181 D111 F113 N115 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLTE 4ygc A 2.40 BS02 CA A 2 D155 D157 N161 N162 D181 D114 D116 N120 N121 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLTE 4ygc B 2.40 BS01 CA B 1 D129 N131 D133 Y135 E140 D50 N52 D54 Y56 E61 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygc B 2.40 BS02 CA B 2 D81 D83 N85 L87 E92 D15 D17 N19 L21 E26 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygc C 2.40 BS01 CA C 1 D152 F154 N156 D181 D111 F113 N115 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygc C 2.40 BS02 CA C 2 D155 D157 N161 N162 D181 D114 D116 N120 N121 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygc D 2.40 BS01 CA D 1 D129 N131 D133 Y135 E140 D52 N54 D56 Y58 E63 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHVMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygc D 2.40 BS02 CA D 2 D81 D83 N85 L87 E92 D15 D17 N19 L21 E26 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHVMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygc E 2.40 BS01 CA E 1 D155 D157 N161 N162 D181 D114 D116 N120 N121 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygc E 2.40 BS02 CA E 2 D152 F154 N156 D181 D111 F113 N115 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygc F 2.40 BS01 CA F 1 D81 D83 N85 L87 E92 D6 D8 N10 L12 E17 YFKMHDYDGNNLLDGLELSTAITMSEDELINIIDGVLRDDDKNNDGYIDYAEFA 4ygc F 2.40 BS02 CA F 2 D129 N131 D133 Y135 E140 D41 N43 D45 Y47 E52 YFKMHDYDGNNLLDGLELSTAITMSEDELINIIDGVLRDDDKNNDGYIDYAEFA 4ygc G 2.40 BS01 CA G 1 D155 D157 N161 N162 D181 D114 D116 N120 N121 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygc G 2.40 BS02 CA G 2 D152 F154 N156 D181 D111 F113 N115 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygc H 2.40 BS01 CA H 1 D81 D83 N85 L87 E92 D9 D11 N13 L15 E20 QLHYFKMHDYDGNNLLDGLELSTAIMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS 4ygc H 2.40 BS02 CA H 2 D129 N131 D133 Y135 E140 D43 N45 D47 Y49 E54 QLHYFKMHDYDGNNLLDGLELSTAIMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS 4ygd A 2.51 BS01 CA A 1 D152 F154 N156 D181 D111 F113 N115 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygd A 2.51 BS02 CA A 2 D155 D157 N161 N162 D181 D114 D116 N120 N121 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygd B 2.51 BS01 CA B 1 D81 D83 N85 L87 E92 D15 D17 N19 L21 E26 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKSL 4ygd B 2.51 BS02 CA B 2 D129 N131 D133 Y135 E140 D53 N55 D57 Y59 E64 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKSL 4ygd C 2.51 BS01 CA C 1 D152 F154 N156 D181 D111 F113 N115 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygd C 2.51 BS02 CA C 2 D155 D157 N161 N162 D181 D114 D116 N120 N121 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygd D 2.51 BS01 CA D 1 D81 D83 N85 L87 E92 D13 D15 N17 L19 E24 PQELQLHYFKMHDYDGNNLLDGLELSTAITMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygd D 2.51 BS02 CA D 2 D129 N131 D133 Y135 E140 D48 N50 D52 Y54 E59 PQELQLHYFKMHDYDGNNLLDGLELSTAITMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 4ygd E 2.51 BS01 CA E 1 D152 F154 N156 D181 D111 F113 N115 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygd E 2.51 BS02 CA E 2 D155 D157 N161 N162 D181 D114 D116 N120 N121 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygd F 2.51 BS01 CA F 1 D81 D83 N85 L87 E92 D15 D17 N19 L21 E26 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITMSEDELINIIDGVLRDDDKNNDGYIDYAEFA 4ygd F 2.51 BS02 CA F 2 D129 N131 D133 Y135 E140 D50 N52 D54 Y56 E61 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITMSEDELINIIDGVLRDDDKNNDGYIDYAEFA 4ygd G 2.51 BS01 CA G 1 D155 D157 N161 N162 D181 D114 D116 N120 N121 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygd G 2.51 BS02 CA G 2 D152 F154 N156 D181 D111 F113 N115 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4ygd H 2.51 BS01 CA H 1 D81 D83 N85 L87 E92 D15 D17 N19 L21 E26 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKSL 4ygd H 2.51 BS02 CA H 2 D129 N131 D133 Y135 E140 D54 N56 D58 Y60 E65 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKSL 4yge A 3.05 BS01 CA A 1 D152 F154 N156 D181 D111 F113 N115 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4yge A 3.05 BS02 CA A 2 D155 D157 N161 N162 D181 D114 D116 N120 N121 D140 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4yge B 3.05 BS01 CA B 1 D129 N131 D133 Y135 I136 E140 D51 N53 D55 Y57 I58 E62 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS 4yge B 3.05 BS02 CA B 2 D81 D83 N85 L87 D89 E92 D15 D17 N19 L21 D23 E26 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS 4yge C 3.05 BS01 CA C 1 P136 H178 P95 H133 PHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLT 4yge D 3.05 BS01 CA D 1 D81 D83 N85 L87 D89 E92 D15 D17 N19 L21 D23 E26 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS 4yge D 3.05 BS02 CA D 2 D129 N131 D133 Y135 I136 E140 D51 N53 D55 Y57 I58 E62 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS 4yge F 3.05 BS01 CA F 1 D81 D83 N85 L87 D89 E92 D15 D17 N19 L21 D23 E26 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS 4yge F 3.05 BS02 CA F 2 D129 N131 D133 Y135 I136 E140 D52 N54 D56 Y58 I59 E63 MSPQELQLHYFKMHDYDGNNLLDGLELSTAITHLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS 4yjd A 2.30 BS01 FAD A 1 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 A48 A49 G50 L51 R162 K163 V164 C181 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 A48 A49 G50 L51 R162 K163 V164 C181 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLAA 4yjd B 2.30 BS01 FAD B 1 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 A48 A49 G50 L51 R162 K163 V164 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 A48 A49 G50 L51 R162 K163 V164 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLL 4yjf A 2.20 BS01 FAD A 1 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 A48 A49 G50 L51 R162 V164 C181 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 A48 A49 G50 L51 R162 V164 C181 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLT 4yjf A 2.20 BS02 98B A 1 A49 Y224 L228 I230 F242 G313 A49 Y224 L228 I230 F242 G313 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLT 4yjf B 2.20 BS01 FAD B 1 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 V47 A48 A49 G50 L51 R162 K163 V164 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 V47 A48 A49 G50 L51 R162 K163 V164 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNL 4yjf B 2.20 BS02 98B B 1 Y224 L228 I230 G313 Y224 L228 I230 G313 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNL 4yjg A 2.50 BS01 4DD A 1 L51 Q53 I215 Y224 L228 F242 G313 L51 Q53 I215 Y224 L228 F242 G313 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLT 4yjg A 2.50 BS02 FAD A 1 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 A48 A49 G50 L51 R162 V164 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 A48 A49 G50 L51 R162 V164 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLT 4yjg B 2.50 BS01 4DD B 1 Q53 Y224 L228 F242 G313 Q53 Y224 L228 F242 G313 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLL 4yjg B 2.50 BS02 FAD B 1 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 V47 A48 A49 G50 L51 R162 K163 V164 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 V47 A48 A49 G50 L51 R162 K163 V164 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLL 4yjh A 2.70 BS01 96B A 1 Y224 L228 I230 F242 G313 Y224 L228 I230 F242 G313 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLAA 4yjh A 2.70 BS02 FAD A 1 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 V47 A48 A49 G50 L51 R162 K163 V164 C181 T182 G183 W185 G200 I202 G281 H311 G312 G313 Y314 G315 L316 T317 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 V47 A48 A49 G50 L51 R162 K163 V164 C181 T182 G183 W185 G200 I202 G281 H311 G312 G313 Y314 G315 L316 T317 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLAA 4yjh B 2.70 BS01 96B B 1 L51 Y224 I230 F242 G313 L51 Y224 I230 F242 G313 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLL 4yjh B 2.70 BS02 FAD B 1 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 V47 A48 A49 G50 L51 R162 K163 V164 C181 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 I6 G7 A8 G9 V10 I11 A36 D37 R38 T43 T44 T45 V47 A48 A49 G50 L51 R162 K163 V164 C181 T182 G183 W185 I202 G281 G312 G313 Y314 G315 L316 T317 1.4.3.3 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPLIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFGPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLL 4ysj A 2.70 BS01 CA A 1 D345 N347 D349 Q351 E356 D323 N325 D327 Q329 E334 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj A 2.70 BS02 CA A 2 D392 D394 N396 F398 E400 E403 D370 D372 N374 F376 E378 E381 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj A 2.70 BS03 CA A 3 D428 D430 S432 K434 E439 D406 D408 S410 K412 E417 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj A 2.70 BS04 CA A 4 D462 N464 D466 E468 D470 E473 D440 N442 D444 E446 D448 E451 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj A 2.70 BS05 MG A 1 N156 D172 N139 D155 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj A 2.70 BS06 ADP A 1 L34 G35 G37 S38 V42 A55 K57 E106 Y108 E112 E155 N156 L158 I171 D172 L27 G28 G30 S31 V35 A48 K50 E89 Y91 E95 E138 N139 L141 I154 D155 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj B 2.70 BS01 CA B 1 D345 N347 D349 Q351 E356 D326 N328 D330 Q332 E337 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDADSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj B 2.70 BS02 CA B 2 D392 D394 N396 F398 E400 E403 D373 D375 N377 F379 E381 E384 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDADSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj B 2.70 BS03 CA B 3 D428 D430 S432 K434 E439 D409 D411 S413 K415 E420 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDADSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj B 2.70 BS04 CA B 4 D462 N464 D466 E468 D470 E473 D443 N445 D447 E449 D451 E454 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDADSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj B 2.70 BS05 MG B 1 N156 D172 N139 D155 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDADSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysj B 2.70 BS06 ADP B 1 L34 G35 G37 S38 V42 A55 K57 T105 E106 Y108 E112 E155 N156 L158 I171 D172 L27 G28 G30 S31 V35 A48 K50 T88 E89 Y91 E95 E138 N139 L141 I154 D155 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDADSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysm A 3.19 BS01 CA A 1 D345 N347 D349 Q351 E356 D339 N341 D343 Q345 E350 DKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysm A 3.19 BS02 CA A 2 D392 D394 N396 F398 E400 E403 D386 D388 N390 F392 E394 E397 DKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysm A 3.19 BS03 CA A 3 D428 D430 S432 K434 E439 D422 D424 S426 K428 E433 DKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysm A 3.19 BS04 CA A 4 D462 N464 D466 E468 D470 E473 D456 N458 D460 E462 D464 E467 DKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysm B 3.19 BS01 CA B 1 D345 N347 D349 Q351 E356 D339 N341 D343 Q345 E350 DKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysm B 3.19 BS02 CA B 2 D392 D394 N396 F398 E400 E403 D386 D388 N390 F392 E394 E397 DKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysm B 3.19 BS03 CA B 3 D428 D430 S432 K434 E439 D422 D424 S426 K428 E433 DKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4ysm B 3.19 BS04 CA B 4 D462 N464 D466 E468 D470 E473 D456 N458 D460 E462 D464 E467 DKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4yuq A 2.80 BS01 CA A 1 D345 N347 D349 Q351 E356 D327 N329 D331 Q333 E338 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yuq A 2.80 BS02 CA A 2 D392 D394 N396 F398 E400 E403 D374 D376 N378 F380 E382 E385 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yuq A 2.80 BS03 CA A 3 D428 D430 S432 K434 E439 D410 D412 S414 K416 E421 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yuq A 2.80 BS04 CA A 4 D462 N464 N465 D466 E468 D470 E473 D444 N446 N447 D448 E450 D452 E455 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yuq A 2.80 BS05 KS1 A 1 L34 G35 V42 A55 K57 E76 M89 L103 T105 E106 V107 Y108 E112 L158 I171 D172 L27 G28 V35 A48 K50 E61 M74 L88 T90 E91 V92 Y93 E97 L143 I156 D157 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yuq B 2.80 BS01 CA B 1 D345 N347 D349 Q351 E356 D326 N328 D330 Q332 E337 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4yuq B 2.80 BS02 CA B 2 D392 D394 N396 F398 E400 E403 D373 D375 N377 F379 E381 E384 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4yuq B 2.80 BS03 CA B 3 D428 D430 S432 K434 E439 D409 D411 S413 K415 E420 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4yuq B 2.80 BS04 CA B 4 D462 N464 D466 E468 D470 E473 D443 N445 D447 E449 D451 E454 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4yuq B 2.80 BS05 KS1 B 1 L34 V42 A55 K57 E76 M89 L103 T105 E106 V107 Y108 E112 L158 I171 D172 L27 V35 A48 K50 E60 M73 L87 T89 E90 V91 Y92 E96 L142 I155 D156 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLKL 4yzb A 2.90 BS01 CA A 1 D345 N347 D349 Q351 E356 D331 N333 D335 Q337 E342 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yzb A 2.90 BS02 CA A 2 D392 D394 N396 F398 E400 E403 D378 D380 N382 F384 E386 E389 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yzb A 2.90 BS03 CA A 3 D428 D430 S432 K434 E439 D414 D416 S418 K420 E425 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yzb A 2.90 BS04 CA A 4 D462 N464 D466 E468 E473 D448 N450 D452 E454 E459 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yzb A 2.90 BS05 BK8 A 1 L34 V42 A55 K57 E76 M89 L103 T105 E106 V107 Y108 E112 E155 L158 L27 V35 A48 K50 E66 M79 L93 T95 E96 V97 Y98 E102 E145 L148 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yzb B 2.90 BS01 CA B 1 D345 N347 D349 Q351 E356 D329 N331 D333 Q335 E340 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yzb B 2.90 BS02 CA B 2 D392 D394 N396 F398 E400 E403 D376 D378 N380 F382 E384 E387 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yzb B 2.90 BS03 CA B 3 D428 D430 S432 K434 E439 D412 D414 S416 K418 E423 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yzb B 2.90 BS04 CA B 4 D462 N464 D466 E468 E473 D446 N448 D450 E452 E457 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4yzb B 2.90 BS05 BK8 B 1 L34 V42 A55 K57 E76 M89 L103 T105 E106 V107 Y108 E112 E155 L158 L27 V35 A48 K50 E66 M79 L93 T95 E96 V97 Y98 E102 E145 L148 KLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKNGFIEYSEFVTVAMDRKTLLSRQRLERAFGMFDADGSGKISSSELATIFGVSEVDSETWRRVLAEVDRNNDGEVDFEEFRQMLLK 4z0y A 1.60 BS01 III E 1 D190 K196 Q202 A205 C206 S209 T210 R217 D190 K196 Q202 A205 C206 S209 T210 R217 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y A 1.60 BS02 CU A 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y A 1.60 BS03 CU A 2 H252 H256 H286 H252 H256 H286 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y B 1.60 BS01 III F 1 D190 K196 Q202 A205 C206 S209 T210 D190 K196 Q202 A205 C206 S209 T210 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y B 1.60 BS02 III H 1 D153 P155 L208 Y212 L215 L295 L299 D153 P155 L208 Y212 L215 L295 L299 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y B 1.60 BS03 CU B 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y B 1.60 BS04 CU B 2 H252 H256 H286 H252 H256 H286 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y C 1.60 BS01 III G 1 D190 K196 Q202 A205 C206 S209 D190 K196 Q202 A205 C206 S209 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y C 1.60 BS02 CU C 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y C 1.60 BS03 CU C 2 H252 H256 H286 H252 H256 H286 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y D 1.60 BS01 III F 1 D153 P155 Q201 V204 L208 V211 Y212 L215 L295 D153 P155 Q201 V204 L208 V211 Y212 L215 L295 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y D 1.60 BS02 III H 1 D190 K196 Q202 A205 C206 S209 T210 D190 K196 Q202 A205 C206 S209 T210 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y D 1.60 BS03 CU D 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0y D 1.60 BS04 CU D 2 H252 H256 H286 H252 H256 H286 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z A 1.60 BS01 III E 1 D190 K196 Q202 A205 C206 S209 R217 D190 K196 Q202 A205 C206 S209 R217 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z A 1.60 BS02 CU A 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z B 1.60 BS01 III F 1 D190 K196 Q202 A205 C206 S209 T210 R217 D190 K196 Q202 A205 C206 S209 T210 R217 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z B 1.60 BS02 III G 1 L208 V211 Y212 L215 V216 L295 L299 L208 V211 Y212 L215 V216 L295 L299 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z B 1.60 BS03 CU B 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z C 1.60 BS01 III F 1 D153 E154 P155 V204 L208 Y212 D153 E154 P155 V204 L208 Y212 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z C 1.60 BS02 III G 1 D190 K196 Q202 A205 C206 S209 T210 D190 K196 Q202 A205 C206 S209 T210 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z C 1.60 BS03 CU C 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z D 1.60 BS01 III H 1 D190 K196 Q202 A205 C206 S209 T210 D190 K196 Q202 A205 C206 S209 T210 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z0z D 1.60 BS02 CU D 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 26976571 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 A 1.93 BS01 III G 1 D190 K196 I198 Q202 A205 C206 S209 Y212 R217 D190 K196 I198 Q202 A205 C206 S209 Y212 R217 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 A 1.93 BS02 CU A 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 A 1.93 BS03 RCO A 1 A73 R76 A168 P171 A73 R76 A168 P171 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 A 1.93 BS04 RCO A 2 D221 P302 G303 D221 P302 G303 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 A 1.93 BS05 RCO C 1 Q201 V204 L208 Q201 V204 L208 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 B 1.93 BS01 III H 1 D190 K196 I198 Q202 A205 C206 L208 S209 Y212 R213 R217 D190 K196 I198 Q202 A205 C206 L208 S209 Y212 R213 R217 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 B 1.93 BS02 CU B 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 B 1.93 BS03 RCO B 1 Q201 V204 L208 Q201 V204 L208 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 B 1.93 BS04 RCO B 2 D221 P302 G303 V305 D221 P302 G303 V305 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 B 1.93 BS05 RCO D 1 Y212 L215 Y212 L215 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 C 1.93 BS01 III G 1 E154 P155 K156 L208 L215 L295 L299 N347 E154 P155 K156 L208 L215 L295 L299 N347 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 C 1.93 BS02 III I 1 D190 K196 Q202 A205 C206 D190 K196 Q202 A205 C206 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 C 1.93 BS03 RCO A 3 P155 L208 P155 L208 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 C 1.93 BS04 CU C 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 C 1.93 BS05 RCO C 1 L208 S209 L208 S209 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 C 1.93 BS06 RCO C 2 D221 P222 G303 V305 D221 P222 G303 V305 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 D 1.93 BS01 III H 1 E154 L208 L215 L295 L299 N347 E154 L208 L215 L295 L299 N347 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 D 1.93 BS02 III J 1 D190 K196 Q202 A205 C206 D190 K196 Q202 A205 C206 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 D 1.93 BS03 CU D 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 D 1.93 BS04 RCO D 1 Y212 V216 Y212 V216 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 D 1.93 BS05 RCO D 2 A73 R76 A168 S169 P171 A73 R76 A168 S169 P171 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 E 1.93 BS01 III K 1 D190 K196 I198 Q202 A205 C206 L208 S209 Y212 R217 D190 K196 I198 Q202 A205 C206 L208 S209 Y212 R217 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 E 1.93 BS02 CU E 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 E 1.93 BS03 RCO E 1 Q201 V204 L208 Q201 V204 L208 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIEN 4z10 F 1.93 BS01 III K 1 K151 E154 P155 K156 L208 V211 Y212 L215 V216 L295 L299 N347 K349 E350 K151 E154 P155 K156 L208 V211 Y212 L215 V216 L295 L299 N347 K349 E350 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIENSKE 4z10 F 1.93 BS02 III L 1 D190 K196 Q202 A205 C206 D190 K196 Q202 A205 C206 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIENSKE 4z10 F 1.93 BS03 RCO E 2 P155 L208 P155 L208 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIENSKE 4z10 F 1.93 BS04 RCO E 1 A205 L208 S209 A205 L208 S209 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIENSKE 4z10 F 1.93 BS05 CU F 1 H93 C97 H116 H125 H252 H93 C97 H116 H125 H252 APITAPDITSICKDASSGIGNQEGAIRTRKCCPPSLGKKIKDFQFPNDKKVRMRWPAHKGTKKQVDDYRRAIAAMRALPDDDPRSFVSQAKIHCAYCNGGYTQVDSGFPDIDIQIHNSWLFFPFHRWYLYFYERILGSLIDEPNFALPYWKWDEPKGMPISNIFLGDASNPLYDQYRDANHIEDRIVDLDYDGKDKDIPDQQQVACNLSTVYRDLVRNGVDPTSFFGGKYVAGDSPVANGDPSVGSVEAGSHTAVHRWVGDPTQPNNEDMGNFYSAGYDPVFYIHHANVDRMWKLWKELRLPGHVDITDPDWLNASYVFYDENKDLVRVYNKDCVNLDKLKYNFIENSKE 4z4k A 2.80 BS01 ZN A 1 C238 C241 H257 H261 C231 C234 H250 H254 SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFVQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGSDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHF 4z4k A 2.80 BS02 ZN A 2 C265 C268 H284 H288 C258 C261 H277 H281 SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFVQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGSDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHF 4z4k B 2.80 BS01 ZN B 1 C238 C241 H257 H261 C230 C233 H249 H253 KGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFVQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGSDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHF 4z4k B 2.80 BS02 ZN B 2 C265 C268 H284 H288 C257 C260 H276 H280 KGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFVQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGSDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHF 4z4m A 2.15 BS01 ZN A 1 C237 C240 H256 H260 C229 C232 H248 H252 MSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFVQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIKVCPMCSEQFPPDYDQQVFERHVQTHF 4z4m B 2.15 BS01 ZN B 1 C237 C240 H256 H260 C229 C232 H248 H252 MSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFVQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIKVCPMCSEQFPPDYDQQVFERHVQTHF 4z51 A 1.86 BS01 GNP A 1 S70 G71 L72 G73 K74 S75 T76 K101 T102 G128 K208 D210 V264 G265 R280 S11 G12 L13 G14 K15 S16 T17 K34 T35 G57 K137 D139 V189 G190 R205 FDFNIMVVGQSGLGKSTLVNTLFKSQNREEKIPKTVEIKAIGHVIVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKR 4z51 A 1.86 BS02 MG A 1 S75 T102 S16 T35 FDFNIMVVGQSGLGKSTLVNTLFKSQNREEKIPKTVEIKAIGHVIVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKR 4z54 A 1.83 BS01 GDP A 1 G33 L34 G35 K36 S37 T38 K170 D172 V226 G227 R242 G19 L20 G21 K22 S23 T24 K153 D155 V209 G210 R225 KKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKR 4z54 A 1.83 BS02 MG A 1 S37 T64 S23 T47 KKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKR 4z54 A 1.83 BS03 GDP B 1 T143 H145 T173 E178 T126 H128 T156 E161 KKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKR 4z54 B 1.83 BS01 GDP A 1 T143 H145 T173 E178 T121 H123 T151 E156 IDTIIEQMRKKMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVKIPKTVEIKAIGHVIKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRL 4z54 B 1.83 BS02 GDP B 1 G33 L34 G35 K36 S37 T38 K170 D172 V226 G227 R242 G27 L28 G29 K30 S31 T32 K148 D150 V204 G205 R220 IDTIIEQMRKKMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVKIPKTVEIKAIGHVIKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRL 4z54 B 1.83 BS03 MG B 1 S37 T64 S31 T47 IDTIIEQMRKKMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVKIPKTVEIKAIGHVIKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRL 4z9r A 2.80 BS01 NAD A 1 A110 N111 A134 G276 H277 D369 T430 H433 F434 R458 W459 L463 S465 W482 A73 N74 A97 G238 H239 D331 T391 H394 F395 R410 W411 L415 S417 W434 SPWPWQVDEISFDIESLGKKLKDLNQACYLINLGIAQHPVSAFAPALGTQSLGDSNFRRVHGVKYAYYAGAMANGIASEELVIALGQAGILCSFGAAGLIPSRVEAAIKRIQAALPNGPYAFNLIHSPSEQALERGSVELFLKHQVRTVEASAFLGLTPQIVYYRAAGLSRDSGEIVIGNKVIAKISRTEVATKFMEPAPVKILQQLVNEGLISEDQMLMAQSVPMADDITAEADSGGHTDNRPLVTLLPTILALKDTIQAKYQYKTPIRVGAGGGIGTPDAALATFNMGAAYIVTGSINQACVEAGASEHTRKLLATTEMADVTMAPAADMFEMGVKLQVVKRGTLFPMRANKLYEIYTRYDSIEIPAEERQKLEEQVFRASLDEIWAGTVAHFKQLDNPKRKMALIFRWYLGLSSRWSNTGEVGREMDYQIWAGPALGAFNAWAKGSYLDDRERNAVDLAKHLMQGAAYQARINLLLSQGVSIPVSLQRWKPL 4z9r A 2.80 BS02 FMN A 1 G107 A108 M109 A110 A134 N160 S189 K223 E271 S274 G313 G314 G335 S336 W482 G70 A71 M72 A73 A97 N123 S152 K185 E233 S236 G275 G276 G297 S298 W434 SPWPWQVDEISFDIESLGKKLKDLNQACYLINLGIAQHPVSAFAPALGTQSLGDSNFRRVHGVKYAYYAGAMANGIASEELVIALGQAGILCSFGAAGLIPSRVEAAIKRIQAALPNGPYAFNLIHSPSEQALERGSVELFLKHQVRTVEASAFLGLTPQIVYYRAAGLSRDSGEIVIGNKVIAKISRTEVATKFMEPAPVKILQQLVNEGLISEDQMLMAQSVPMADDITAEADSGGHTDNRPLVTLLPTILALKDTIQAKYQYKTPIRVGAGGGIGTPDAALATFNMGAAYIVTGSINQACVEAGASEHTRKLLATTEMADVTMAPAADMFEMGVKLQVVKRGTLFPMRANKLYEIYTRYDSIEIPAEERQKLEEQVFRASLDEIWAGTVAHFKQLDNPKRKMALIFRWYLGLSSRWSNTGEVGREMDYQIWAGPALGAFNAWAKGSYLDDRERNAVDLAKHLMQGAAYQARINLLLSQGVSIPVSLQRWKPL 4z9r B 2.80 BS01 NAD B 1 A110 A134 I162 H277 D369 H433 F434 R458 W459 G462 R466 A71 A95 I123 H238 D330 H393 F394 R415 W416 G419 R423 PWQVISFDIESLGKKLKDLNQACYLINAELGIAQSAEVSAFAPALGTQSLGDSNFRRVHGVKYAYYAGAMANGIASEELVIALGQAGILCSFGAAGLIPSRVEAAIKRIQAALPNGPYAFNLIHSPSEQALERGSVELFLKHQVRTVEASAFLGLTPQIVYYRAAGLSRDASGEIVIGNKVIAKISRTEVATKFMEPAPVKILQQLVNEGLISEDQMLMAQSVPMADDITAEADSGGHTDNRPLVTLLPTILALKDTIQAKYQYKTPIRVGAGGGIGTPDAALATFNMGAAYIVTGSINQACVEAGASEHTRKLLATTEMADVTMAPAADMFEMGVKLQVVKRGTLFPMRANKLYEIYTRYDSIEAIAEERQKLEEQVFRASLDEIWAGTVAHFNERPIERALDNPKRKMALIFRWYLGLSSRWSNTGEVGREMDYQIWAGPALGAFNAWAKGSYLDDYRERNAVDLAKHLMQGAAYQARINLLLSQGVSIPVSLQRWKPL 4z9r B 2.80 BS02 FMN B 1 G107 A108 M109 A110 A134 N160 S189 K223 E271 S274 G313 G314 G335 S336 Q339 W482 G68 A69 M70 A71 A95 N121 S150 K184 E232 S235 G274 G275 G296 S297 Q300 W439 PWQVISFDIESLGKKLKDLNQACYLINAELGIAQSAEVSAFAPALGTQSLGDSNFRRVHGVKYAYYAGAMANGIASEELVIALGQAGILCSFGAAGLIPSRVEAAIKRIQAALPNGPYAFNLIHSPSEQALERGSVELFLKHQVRTVEASAFLGLTPQIVYYRAAGLSRDASGEIVIGNKVIAKISRTEVATKFMEPAPVKILQQLVNEGLISEDQMLMAQSVPMADDITAEADSGGHTDNRPLVTLLPTILALKDTIQAKYQYKTPIRVGAGGGIGTPDAALATFNMGAAYIVTGSINQACVEAGASEHTRKLLATTEMADVTMAPAADMFEMGVKLQVVKRGTLFPMRANKLYEIYTRYDSIEAIAEERQKLEEQVFRASLDEIWAGTVAHFNERPIERALDNPKRKMALIFRWYLGLSSRWSNTGEVGREMDYQIWAGPALGAFNAWAKGSYLDDYRERNAVDLAKHLMQGAAYQARINLLLSQGVSIPVSLQRWKPL 4zus A 2.60 BS01 III C 1 Y7 R62 E63 N66 N73 G77 T80 L81 Y84 L95 R97 Y99 R114 D116 T143 K146 R147 A150 E152 Q155 Y159 T163 W167 Y171 Y7 R62 E63 N66 N73 G77 T80 L81 Y84 L95 R97 Y99 R114 D116 T143 K146 R147 A150 E152 Q155 Y159 T163 W167 Y171 26764037 GSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMEPRAPWVEQEGPEYWERETRNMKEATQNFRVGLNTLHGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGYRQDAYDGADYIALNEDLRSWTAADAAAQITRRKREEAGEAEQCRNYLEGTCVEWLLRYLENGNETLQRADAPKTHVTHHPISDHEVTLRCWALGFYPEEISLSWQRDGEDVTQDTEFVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLAEPVTLRW 4zut A 2.60 BS01 III C 1 M5 Y7 E63 N66 E69 N73 F74 G77 T80 Y84 L95 R97 Y99 R114 D116 T143 K146 R147 A150 E152 Q155 Y159 W167 Y171 M5 Y7 E63 N66 E69 N73 F74 G77 T80 Y84 L95 R97 Y99 R114 D116 T143 K146 R147 A150 E152 Q155 Y159 W167 Y171 26764037 GSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMEPRAPWVEQEGPEYWERETRNMKEATQNFRVGLNTLHGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGYRQDAYDGADYIALNEDLRSWTAADAAAQITRRKREEAGEAEQCRNYLEGTCVEWLLRYLENGNETLQRADAPKTHVTHHPISDHEVTLRCWALGFYPEEISLSWQRDGEDVTQDTEFVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLAEPVTLRW 4zuu A 2.20 BS01 III C 1 Y7 M45 R62 E63 N66 G77 L81 Y84 L95 R97 Y99 R114 T143 K146 R147 E152 Y159 W167 Y171 Y7 M45 R62 E63 N66 G77 L81 Y84 L95 R97 Y99 R114 T143 K146 R147 E152 Y159 W167 Y171 26764037 GSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMEPRAPWVEQEGPEYWERETRNMKEATQNFRVGLNTLHGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGYRQDAYDGADYIALNEDLRSWTAADAAAQITRRKREEAGEAEQCRNYLEGTCVEWLLRYLENGNETLQRADAPKTHVTHHPISDHEVTLRCWALGFYPEEISLSWQRDGEDVTQDTEFVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLAEPVTLRW 4zuv A 2.30 BS01 III C 1 Y7 M45 R62 E63 N66 E69 A70 N73 V76 G77 T80 Y84 L95 Y99 R114 D116 T143 K146 R147 A150 E152 C156 Y159 T163 W167 Y171 Y7 M45 R62 E63 N66 E69 A70 N73 V76 G77 T80 Y84 L95 Y99 R114 D116 T143 K146 R147 A150 E152 C156 Y159 T163 W167 Y171 26764037 GSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMEPRAPWVEQEGPEYWERETRNMKEATQNFRVGLNTLHGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGYRQDAYDGADYIALNEDLRSWTAADAAAQITRRKREEAGEAEQCRNYLEGTCVEWLLRYLENGNETLQRADAPKTHVTHHPISDHEVTLRCWALGFYPEEISLSWQRDGEDVTQDTEFVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLAEPVTLRW 4zuv D 2.30 BS01 III F 1 M5 Y7 M45 R62 E63 N66 E69 A70 N73 V76 G77 T80 L81 Y84 Y99 R114 D116 T143 K146 R147 A150 E152 C156 Y159 T163 W167 Y171 M5 Y7 M45 R62 E63 N66 E69 A70 N73 V76 G77 T80 L81 Y84 Y99 R114 D116 T143 K146 R147 A150 E152 C156 Y159 T163 W167 Y171 26764037 GSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMEPRAPWVEQEGPEYWERETRNMKEATQNFRVGLNTLHGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGYRQDAYDGADYIALNEDLRSWTAADAAAQITRRKREEAGEAEQCRNYLEGTCVEWLLRYLENGNETLQRADAPKTHVTHHPISDHEVTLRCWALGFYPEEISLSWQRDGEDVTQDTEFVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLAEPVTLRW 4zuw A 2.60 BS01 III C 1 Y7 E63 N66 N73 G77 T80 Y84 L95 R97 Y99 D116 T143 K146 R147 V152 Q155 C156 Y159 W167 Y171 Y7 E63 N66 N73 G77 T80 Y84 L95 R97 Y99 D116 T143 K146 R147 V152 Q155 C156 Y159 W167 Y171 26764037 GSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMEPRAPWVEQEGPEYWERETRNMKEATQNFRVGLNTLHGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGYRQDAYDGADYIALNEDLRSWTAADAAAQITRRKREEAGVAEQCRNYLEGTCVEWLLRYLENGNETLQRADAPKTHVTHHPISDHEVTLRCWALGFYPEEISLSWQRDGEDVTQDTEFVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLAEPVTLRW 4zvl A 1.90 BS01 ZN A 1 H173 H177 C222 H173 H177 C222 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl A 1.90 BS02 FAD A 1 H11 K15 S16 F17 N18 S20 P102 L103 Y104 W105 F106 T147 T148 G149 G150 Y155 E193 E197 R200 K201 H11 K15 S16 F17 N18 S20 P102 L103 Y104 W105 F106 T147 T148 G149 G150 Y155 E193 E197 R200 K201 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl A 1.90 BS03 AO A 1 F126 I128 G174 F178 F126 I128 G174 F178 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl A 1.90 BS04 ZN A 2 H72 D127 H72 D127 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl A 1.90 BS05 AO B 1 W105 F106 G149 Y155 N161 E193 I194 W105 F106 G149 Y155 N161 E193 I194 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl A 1.90 BS06 FAD B 1 N66 D117 N66 D117 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl B 1.90 BS01 FAD A 1 N66 Y67 D117 N66 Y67 D117 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl B 1.90 BS02 AO A 1 W105 F106 G149 N161 E193 W105 F106 G149 N161 E193 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl B 1.90 BS03 AO B 1 F126 I128 G174 F178 F126 I128 G174 F178 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl B 1.90 BS04 ZN B 1 H173 H177 C222 H173 H177 C222 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvl B 1.90 BS05 FAD B 1 H11 K15 S16 F17 N18 S20 P102 L103 Y104 W105 F106 T147 T148 G149 G150 Y155 E193 R200 K201 H11 K15 S16 F17 N18 S20 P102 L103 Y104 W105 F106 T147 T148 G149 G150 Y155 E193 R200 K201 1.10.99.2 26636353 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zz7 A 2.90 BS01 NAD A 1 I145 T146 P147 F148 N149 K172 P173 E175 R176 K205 V208 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 N410 F449 I145 T146 P147 F148 N149 K172 P173 E175 R176 K205 V208 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 N410 F449 26832667 MTTIGHLINGQLVTENTRSQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPELLKGEHSRNVGPGIDSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVTQRWPSAGVREG 4zz7 C 2.90 BS01 NAD C 1 I145 T146 P147 F148 N149 K172 E175 R176 K205 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 N410 F449 I145 T146 P147 F148 N149 K172 E175 R176 K205 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 N410 F449 26832667 MTTIGHLINGQLVTENTRSQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPELLKGEHSRNVGPGIDSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVTQRWPSAGVR 4zz7 D 2.90 BS01 NAD D 1 I145 T146 P147 F148 N149 K172 E175 R176 K205 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 N410 F449 I145 T146 P147 F148 N149 K172 E175 R176 K205 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 N410 F449 26832667 MTTIGHLINGQLVTENTRSQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPELLKGEHSRNVGPGIDSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVTQRWPSAGVRE 4zz7 E 2.90 BS01 NAD E 1 I145 T146 P147 F148 N149 K172 S174 E175 R176 K205 V208 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 F449 I145 T146 P147 F148 N149 K172 S174 E175 R176 K205 V208 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 F449 26832667 MTTIGHLINGQLVTENTRSQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPELLKGEHSRNVGPGIDSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVTQRWPSAGVRE 4zz7 I 2.90 BS01 NAD I 1 I145 T146 P147 F148 N149 K172 P173 S174 E175 R176 K205 V208 F222 V223 G224 S225 I228 L246 G247 C280 E382 F384 N410 F449 I145 T146 P147 F148 N149 K172 P173 S174 E175 R176 K205 V208 F222 V223 G224 S225 I228 L246 G247 C280 E382 F384 N410 F449 26832667 MTTIGHLINGQLVTENTRSQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPELLKGEHSRNVGPGIDSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVTQRWPSAGVRE 4zz7 L 2.90 BS01 NAD L 1 I145 T146 P147 F148 N149 K172 P173 E175 R176 K205 V208 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 N410 F449 I145 T146 P147 F148 N149 K172 P173 E175 R176 K205 V208 F222 V223 G224 S225 I228 L246 G247 G248 C280 E382 F384 N410 F449 26832667 MTTIGHLINGQLVTENTRSQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPELLKGEHSRNVGPGIDSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVTQRWPSAGVRE 5aeu A 2.49 BS01 FES A 1 C100 H102 R103 M105 C120 Y122 H123 W125 C83 H85 R86 M88 C103 Y105 H106 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aeu A 2.49 BS02 FE2 A 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aeu C 2.49 BS01 FES C 1 C100 H102 R103 G104 M105 C120 Y122 H123 G124 W125 C83 H85 R86 G87 M88 C103 Y105 H106 G107 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aeu C 2.49 BS02 FE2 C 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aeu E 2.49 BS01 FES E 1 C100 H102 R103 M105 C120 Y122 H123 W125 C83 H85 R86 M88 C103 Y105 H106 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aeu E 2.49 BS02 FE2 E 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aeu G 2.49 BS01 FES G 1 C100 H102 R103 M105 C120 Y122 H123 W125 C83 H85 R86 M88 C103 Y105 H106 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aeu G 2.49 BS02 FE2 G 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew A 1.88 BS01 FES A 1 C100 H102 R103 M105 C120 Y122 H123 W125 C83 H85 R86 M88 C103 Y105 H106 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew A 1.88 BS02 FE2 A 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew C 1.88 BS01 FES C 1 C100 H102 R103 M105 C120 Y122 H123 G124 W125 C83 H85 R86 M88 C103 Y105 H106 G107 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew C 1.88 BS02 FE2 C 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew C 1.88 BS03 BNL C 1 Q226 F227 D230 M231 H233 H323 L333 Q200 F201 D204 M205 H207 H297 L307 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew E 1.88 BS01 FES E 1 C100 H102 R103 M105 C120 Y122 H123 G124 W125 C83 H85 R86 M88 C103 Y105 H106 G107 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew E 1.88 BS02 FE2 E 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew E 1.88 BS03 BNL E 1 Q226 D230 M231 H233 V287 H323 L333 Q200 D204 M205 H207 V261 H297 L307 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew G 1.88 BS01 FES G 1 C100 H102 R103 M105 C120 Y122 H123 G124 W125 C83 H85 R86 M88 C103 Y105 H106 G107 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew G 1.88 BS02 FE2 G 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew I 1.88 BS01 FES I 1 C100 H102 R103 M105 C120 Y122 H123 G124 W125 C83 H85 R86 M88 C103 Y105 H106 G107 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew I 1.88 BS02 FE2 I 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew I 1.88 BS03 BNL I 1 Q226 F227 D230 M231 H233 H323 L333 Q200 F201 D204 M205 H207 H297 L307 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew K 1.88 BS01 FES K 1 C100 H102 R103 M105 C120 Y122 H123 W125 C83 H85 R86 M88 C103 Y105 H106 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew K 1.88 BS02 FE2 K 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew K 1.88 BS03 BNL K 1 Q226 F227 D230 M231 H233 V287 H323 L333 F378 F384 Q200 F201 D204 M205 H207 V261 H297 L307 F352 F358 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew M 1.88 BS01 FES M 1 C100 H102 R103 M105 C120 Y122 H123 G124 W125 C83 H85 R86 M88 C103 Y105 H106 G107 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew M 1.88 BS02 FE2 M 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew M 1.88 BS03 BNL M 1 Q226 F227 D230 M231 H233 V287 H323 L333 F378 F384 Q200 F201 D204 M205 H207 V261 H297 L307 F352 F358 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew O 1.88 BS01 FES O 1 C100 H102 R103 M105 C120 Y122 H123 G124 W125 C83 H85 R86 M88 C103 Y105 H106 G107 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew O 1.88 BS02 FE2 O 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew O 1.88 BS03 BNL O 1 Q226 F227 D230 M231 H233 H323 L333 F384 Q200 F201 D204 M205 H207 H297 L307 F358 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew Q 1.88 BS01 FES Q 1 C100 H102 R103 M105 C120 Y122 H123 W125 C83 H85 R86 M88 C103 Y105 H106 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew Q 1.88 BS02 FE2 Q 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew Q 1.88 BS03 BNL Q 1 Q226 D230 M231 H233 A234 G321 H323 L333 Q200 D204 M205 H207 A208 G295 H297 L307 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew S 1.88 BS01 FES S 1 C100 H102 R103 M105 C120 Y122 H123 W125 C83 H85 R86 M88 C103 Y105 H106 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew S 1.88 BS02 FE2 S 1 Q226 H233 H239 D388 Q200 H207 H213 D362 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew S 1.88 BS03 BNL S 1 Q226 F227 D230 M231 H233 H323 L333 F378 F384 Q200 F201 D204 M205 H207 H297 L307 F352 F358 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew U 1.88 BS01 FES U 1 C100 H102 R103 M105 C120 Y122 H123 W125 C83 H85 R86 M88 C103 Y105 H106 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLK 5aew U 1.88 BS02 FE2 U 1 Q226 H233 H239 D388 Q198 H205 H211 D360 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLK 5aew W 1.88 BS01 FES W 1 C100 H102 R103 M105 C120 Y122 H123 W125 C83 H85 R86 M88 C103 Y105 H106 W108 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew W 1.88 BS02 FE2 W 1 Q226 H233 H239 D388 Q199 H206 H212 D361 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5aew W 1.88 BS03 BNL W 1 Q226 F227 D230 M231 H233 A234 H323 L333 I336 Q199 F200 D203 M204 H206 A207 H296 L306 I309 1.14.12.18 26953337 NWTPEAIRGLVDQEKGLLDPRIYADQSLYELELERVFGRSWLLLGHESHVPETGDFLATYMGEDPVVMVRQKDKSIKVFLNQCRHRGMRICRSDAGNAKAFTCSYHGWAYDIAGKLVNVPFEKEAFDKAEWGPLQARVATYKGLVFANWDVQAPDLETYLGDARPYMDVMLDRTPAGTVAIGGMQKWVIPCNWKFAAEQFCSDMYHAGTTTHLSGILAGIPPEMDLSQAQIPTKGNQFRAAWGGHGSGWYVDEPGSLLAVMGPKVTQYWTEGPAAELAEQRLGHTGMPVRRMVGQHMTIFPTCSFLPGINTIRTWHPRGPNEIEVWAFTLVDADAPAEIKEEYRRHNIRNFSAGGVFEQDDGENWVEIQKGLRGYKAKSQPLNAQMGLGRSQTGHPDFPGNVGYVYAEEAARGMYHHWMRMMSEPSWATLKP 5ay8 A 2.80 BS01 NUC I 1 R40 K42 P43 T45 R49 R63 R72 R83 F84 Q85 R116 V117 T118 M120 R3 K5 P6 T8 R12 R26 R35 R46 F47 Q48 R79 V80 T81 M83 27016736 PHRYKPGTLALREIRKYQKSTQLLLRKLPFQRLVREIAQAISPDLRFQSAAIGALQEASEAYLVQLFEDTNLCAIHARRVTIMPRDMQLARRLRREG 5ay8 A 2.80 BS02 NUC J 1 R40 Y41 P43 G44 T45 L46 A47 R49 K56 R63 K64 L65 P66 R69 R83 R3 Y4 P6 G7 T8 L9 A10 R12 K19 R26 K27 L28 P29 R32 R46 27016736 PHRYKPGTLALREIRKYQKSTQLLLRKLPFQRLVREIAQAISPDLRFQSAAIGALQEASEAYLVQLFEDTNLCAIHARRVTIMPRDMQLARRLRREG 5ay8 B 2.80 BS01 NUC I 1 P32 R36 K77 P8 R12 K53 27016736 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 5ay8 B 2.80 BS02 NUC J 1 R35 R45 I46 S47 G48 K79 T80 R11 R21 I22 S23 G24 K55 T56 27016736 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 5ay8 B 2.80 BS03 MN A 1 G28 T30 A33 G4 T6 A9 27016736 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 5ay8 C 2.80 BS01 NUC I 1 A14 K15 R17 R20 R32 K74 R77 A1 K2 R4 R7 R19 K61 R64 27016736 AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 5ay8 C 2.80 BS02 NUC J 1 R29 R42 V43 G44 A45 T76 R77 R16 R29 V30 G31 A32 T63 R64 27016736 AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 5ay8 D 2.80 BS01 NUC I 1 Y42 G53 I54 S55 S56 R86 S87 T88 Y10 G21 I22 S23 S24 R54 S55 T56 27016736 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 5ay8 D 2.80 BS02 NUC J 1 R33 K34 E35 S36 I39 Y40 R1 K2 E3 S4 I7 Y8 27016736 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 5ay8 E 2.80 BS01 NUC I 1 R40 Y41 P43 G44 T45 L46 A47 R49 K56 R63 K64 L65 R69 R83 R3 Y4 P6 G7 T8 L9 A10 R12 K19 R26 K27 L28 R32 R46 27016736 PHRYKPGTLALREIRKYQKSTQLLLRKLPFQRLVREIAQAISPDLRFQSAAIGALQEASEAYLVQLFEDTNLCAIHARRVTIMPRDMQLARRLRRE 5ay8 E 2.80 BS02 NUC J 1 H39 R40 Y41 K42 P43 T45 R49 R63 R72 R83 F84 Q85 S86 R116 V117 T118 M120 R122 H2 R3 Y4 K5 P6 T8 R12 R26 R35 R46 F47 Q48 S49 R79 V80 T81 M83 R85 27016736 PHRYKPGTLALREIRKYQKSTQLLLRKLPFQRLVREIAQAISPDLRFQSAAIGALQEASEAYLVQLFEDTNLCAIHARRVTIMPRDMQLARRLRRE 5ay8 F 2.80 BS01 NUC I 1 R35 R45 I46 S47 G48 R78 K79 T80 R12 R22 I23 S24 G25 R55 K56 T57 27016736 DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 5ay8 F 2.80 BS02 NUC J 1 T30 P32 R36 R45 T7 P9 R13 R22 27016736 DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 5ay8 G 2.80 BS01 NUC I 1 R29 R42 V43 G44 A45 K75 T76 R77 R15 R28 V29 G30 A31 K61 T62 R63 27016736 KTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 5ay8 G 2.80 BS02 NUC J 1 R17 G28 R29 R32 R42 R77 R3 G14 R15 R18 R28 R63 27016736 KTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 5ay8 G 2.80 BS03 MN G 1 G44 A45 G46 A47 G30 A31 G32 A33 27016736 KTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 5ay8 H 2.80 BS01 NUC I 1 K34 E35 S36 I39 Y40 K2 E3 S4 I7 Y8 27016736 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 5ay8 H 2.80 BS02 NUC J 1 R33 Y42 G53 I54 S55 S56 R86 S87 T88 R1 Y10 G21 I22 S23 S24 R54 S55 T56 27016736 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 5ay8 H 2.80 BS03 MN G 1 T90 S91 T58 S59 27016736 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 5bmg A 2.20 BS01 MTN A 1 K4 C15 K4 C15 26948069 MQYKLILNGKTLKGCTTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE 5bmg B 2.20 BS01 MTN B 1 K4 I6 C15 T16 K4 I6 C15 T16 26948069 MQYKLILNGKTLKGCTTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE 5bmg B 2.20 BS02 MTN B 2 I6 K13 G14 I6 K13 G14 26948069 MQYKLILNGKTLKGCTTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE 5bmg D 2.20 BS01 MTN D 1 K4 C15 K4 C15 26948069 MQYKLILNGKTLKGCTTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE 5bmg E 2.20 BS01 MTN E 1 K4 C15 K4 C15 26948069 MQYKLILNGKTLKGCTTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE 5bmg F 2.20 BS01 MTN F 1 K4 C15 K4 C15 26948069 MQYKLILNGKTLKGCTTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE 5bmg G 2.20 BS01 MTN G 1 K4 C15 K4 C15 26948069 MQYKLILNGKTLKGCTTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE 5bmh A 1.60 BS01 MTN A 1 C44 D46 T51 T53 C44 D46 T51 T53 26948069 MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWCYDDATKTFTVTE 5cad A 1.49 BS01 MG A 1 A25 G28 A21 G24 27004988 QQESNVPYLFKVVRFKSRFRASHGDFRILPKFVQRSQLLRGIEKFRVSVIELEPQSFMLPHHCDGEAIFVVVKGQGVIVIAEQDKNNSFNLQKGDVLRLHGGSTIFLLNADANEKFKVYVLAKSVNAPGEVQEYFSAGGQNPESFYRAFVVDILESAFNVKRDKIERLFSQQKAGAIISASGAQAAAKAGHASAAGGAAAAARVAGPFNLMKEVPEFGSAFGQFQEAAPQRHVQLRDLDAAVAFMNINSGGMVLPYYNSRSTRVVAVVEGNARFEMACPHLGAAVVHYAKVRGNLNVGDVLVIPAGHPITFVAVAGSDFRVVGFGIDAEHNKKNFLAGKQNIWRNIDREAKELSFDMPGAEVEEIFAKQILSYFVAGPA 5cad A 1.49 BS02 ACT A 1 F228 Y260 N262 R267 K346 F224 Y256 N258 R263 K333 27004988 QQESNVPYLFKVVRFKSRFRASHGDFRILPKFVQRSQLLRGIEKFRVSVIELEPQSFMLPHHCDGEAIFVVVKGQGVIVIAEQDKNNSFNLQKGDVLRLHGGSTIFLLNADANEKFKVYVLAKSVNAPGEVQEYFSAGGQNPESFYRAFVVDILESAFNVKRDKIERLFSQQKAGAIISASGAQAAAKAGHASAAGGAAAAARVAGPFNLMKEVPEFGSAFGQFQEAAPQRHVQLRDLDAAVAFMNINSGGMVLPYYNSRSTRVVAVVEGNARFEMACPHLGAAVVHYAKVRGNLNVGDVLVIPAGHPITFVAVAGSDFRVVGFGIDAEHNKKNFLAGKQNIWRNIDREAKELSFDMPGAEVEEIFAKQILSYFVAGPA 5cad A 1.49 BS03 PCA A 1 F30 H65 C67 F73 I109 A126 V135 F26 H61 C63 F69 I105 A122 V131 27004988 QQESNVPYLFKVVRFKSRFRASHGDFRILPKFVQRSQLLRGIEKFRVSVIELEPQSFMLPHHCDGEAIFVVVKGQGVIVIAEQDKNNSFNLQKGDVLRLHGGSTIFLLNADANEKFKVYVLAKSVNAPGEVQEYFSAGGQNPESFYRAFVVDILESAFNVKRDKIERLFSQQKAGAIISASGAQAAAKAGHASAAGGAAAAARVAGPFNLMKEVPEFGSAFGQFQEAAPQRHVQLRDLDAAVAFMNINSGGMVLPYYNSRSTRVVAVVEGNARFEMACPHLGAAVVHYAKVRGNLNVGDVLVIPAGHPITFVAVAGSDFRVVGFGIDAEHNKKNFLAGKQNIWRNIDREAKELSFDMPGAEVEEIFAKQILSYFVAGPA 5clv A 2.50 BS01 NUC C 1 P36 Q37 A38 R48 G49 S52 Q53 P35 Q36 A37 R47 G48 S51 Q52 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADAKKK 5clv A 2.50 BS02 NUC D 1 E18 V19 G20 Q22 T23 T47 A50 Q53 R57 E17 V18 G19 Q21 T22 T46 A49 Q52 R56 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADAKKK 5clv B 2.50 BS01 NUC C 1 E18 G20 Q22 T23 L46 T47 A50 Q53 R57 E17 G19 Q21 T22 L45 T46 A49 Q52 R56 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADAKKKQ 5clv B 2.50 BS02 NUC D 1 K3 P36 Q37 A38 R48 G49 S52 Q53 K2 P35 Q36 A37 R47 G48 S51 Q52 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADAKKKQ 5clv E 2.50 BS01 NUC G 1 K2 E18 V19 G20 Q22 T23 L46 T47 A50 Q53 R57 K1 E17 V18 G19 Q21 T22 L45 T46 A49 Q52 R56 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKN 5clv E 2.50 BS02 NUC H 1 P36 Q37 A38 R48 G49 S52 Q53 P35 Q36 A37 R47 G48 S51 Q52 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKN 5clv F 2.50 BS01 NUC G 1 P36 Q37 A38 R48 G49 S52 Q53 P35 Q36 A37 R47 G48 S51 Q52 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDK 5clv F 2.50 BS02 NUC H 1 K2 E18 V19 G20 Q22 T23 L46 T47 G49 A50 Q53 R57 K1 E17 V18 G19 Q21 T22 L45 T46 G48 A49 Q52 R56 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDK 5clv I 2.50 BS01 NUC K 1 Q37 A38 R48 G49 S52 Q53 Q34 A35 R45 G46 S49 Q50 27016739 RLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDK 5clv I 2.50 BS02 NUC L 1 E18 G20 Q22 T23 G45 L46 T47 A50 Q53 R57 E15 G17 Q19 T20 G42 L43 T44 A47 Q50 R54 27016739 RLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDK 5clv J 2.50 BS01 NUC K 1 E18 V19 G20 Q22 T23 T47 A50 Q53 R57 E16 V17 G18 Q20 T21 T45 A48 Q51 R55 27016739 KRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDK 5clv J 2.50 BS02 NUC L 1 P36 Q37 A38 R48 G49 S52 Q53 H56 P34 Q35 A36 R46 G47 S50 Q51 H54 27016739 KRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDK 5clv M 2.50 BS01 NUC O 1 E18 V19 G20 Q22 T23 T47 A50 Q53 R57 E17 V18 G19 Q21 T22 T46 A49 Q52 R56 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFED 5clv M 2.50 BS02 NUC P 1 P36 Q37 A38 R48 G49 S52 Q53 P35 Q36 A37 R47 G48 S51 Q52 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFED 5clv N 2.50 BS01 NUC O 1 P36 Q37 A38 R48 G49 S52 Q53 P35 Q36 A37 R47 G48 S51 Q52 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDK 5clv N 2.50 BS02 NUC P 1 E18 V19 G20 Q22 T23 L46 T47 A50 Q53 R57 E17 V18 G19 Q21 T22 L45 T46 A49 Q52 R56 27016739 KKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDK 5cm3 A 2.30 BS01 NUC C 1 K3 P36 Q37 A38 R48 G49 S52 Q53 K3 P36 Q37 A38 R48 G49 S52 Q53 27016739 MKKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADAKKKQ 5cm3 A 2.30 BS02 NUC D 1 E18 V19 G20 Q22 T23 L46 T47 A50 Q53 R57 E18 V19 G20 Q22 T23 L46 T47 A50 Q53 R57 27016739 MKKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADAKKKQ 5cm3 B 2.30 BS01 NUC C 1 M1 E18 V19 G20 Q22 T23 L46 T47 A50 Q53 R57 M1 E18 V19 G20 Q22 T23 L46 T47 A50 Q53 R57 27016739 MKKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADA 5cm3 B 2.30 BS02 NUC D 1 K3 P36 Q37 A38 R48 G49 S52 Q53 K3 P36 Q37 A38 R48 G49 S52 Q53 27016739 MKKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADA 5cqx A 1.63 BS01 III C 1 R29 T43 M45 P50 T52 Q54 K56 E61 L74 Q77 K79 I81 A82 A85 R86 R18 T32 M34 P39 T41 Q43 K45 E50 L61 Q64 K66 I68 A69 A72 R73 3.1.27.- VSRYVPDMGDLIWVDFHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQEGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIGLSHHHHHH 5cqx B 1.63 BS01 III C 1 K21 R29 C48 V49 P50 L74 Q77 K79 K19 R27 C46 V47 P48 L71 Q74 K76 3.1.27.- SRYVPDMGDLIWVDFDPTKGSAQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIGLSHHHHHH 5cqy A 2.48 BS01 III C 1 F17 D18 R29 M45 P50 Y58 L74 D76 Q77 K79 I81 A82 R86 F16 D17 R21 M37 P42 Y50 L64 D66 Q67 K69 I71 A72 R76 3.1.27.- VSRYVPDMGDLIWVDFDPGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQEGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIGL 5cqy B 2.48 BS01 III C 1 F17 R29 M45 P50 Q77 K79 R86 F16 R18 M34 P39 Q66 K68 R75 3.1.27.- VSRYVPDMGDLIWVDFHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIGLS 5cr2 A 2.90 BS01 NUC D 1 W14 S23 E24 Q25 A26 H28 R29 P30 T52 T53 Q54 K56 Y58 E68 R69 W13 S22 E23 Q24 A25 H27 R28 P29 T51 T52 Q53 K55 Y57 E67 R68 3.1.27.- VSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIGH 5cr2 B 2.90 BS01 NUC D 1 K42 T43 K39 T40 3.1.27.- RYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG 5cr2 B 2.90 BS02 NUC E 1 W14 R29 P30 T52 T53 Q54 E68 R69 K91 W11 R26 P27 T49 T50 Q51 E65 R66 K88 3.1.27.- RYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG 5cr2 C 2.90 BS01 NUC F 1 H28 R29 P30 C51 T52 R69 H26 R27 P28 C49 T50 R67 3.1.27.- SRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIGH 5d0y A 3.01 BS01 FOL A 1 A37 T38 L39 Q40 V41 G42 D68 S72 N77 L78 G80 F81 F82 F85 T86 Y122 N126 V130 R145 K148 E149 A25 T26 L27 Q28 V29 G30 D56 S60 N65 L66 G68 F69 F70 F73 T74 Y110 N114 V118 R133 K136 E137 LRELVLLAMVIAIKVVLGQFKVGDATLQVGLGFIGSVMLGYLFGPWWGFAGGALSDLVSSAIFGNLGGFFIGFTLTAALESMIYGFFLYKKPIQIWRVIASVICVTVICYIGLNTLWVSMLGGTNFMVALSSRILKEMITPWIHMVVVWFILEGL 5d0y B 3.01 BS01 FOL B 1 A37 T38 L39 Q40 G42 D68 N77 L78 G80 F81 F82 F85 T86 Y122 N126 V130 R145 K148 E149 A25 T26 L27 Q28 G30 D56 N65 L66 G68 F69 F70 F73 T74 Y110 N114 V118 R133 K136 E137 LRELVLLAMVIAIKVVLGQFKVGDATLQVGLGFIGSVMLGYLFGPWWGFAGGALSDLVSSAIFGNLGGFFIGFTLTAALESMIYGFFLYKKPIQIWRVIASVICVTVICYIGLNTLWVSMLGGTNFMVALSSRILKEMITPWIHMVVVWFILEGL 5d3m A 3.30 BS01 ANP A 1 F13 T14 N42 G43 K46 S47 Q91 H202 F13 T14 N42 G43 K46 S47 Q91 H202 3.6.3.- GSDNIISFDHVTFTYPDSPRPALSDLSFAIERGSWTALIGHNGSGKSTVSKLINGLLAPDDLDKSSITVDGVKLGADTVWEVREKVGIVFQNPDNQFVGATVSDDVAFGLENRAVPRPEMLKIVAQAVADVGMADYADSEPSNLSGGQKQRVAIAGILAVKPQVIILDESTSMLDPEGKEQILDLVRKIKEDNNLTVISITHDLEEAAGADQVLVLDDGQLLDQGKPEEIFPKVEMLKRIGLDIPFVYRLKQLLKERGIVLPDEIDDDEKLVQSLWQLNS 5d3m B 3.30 BS01 ANP B 1 Y12 T42 G43 S44 G45 K46 S47 D170 Y11 T41 G42 S43 G44 K45 S46 D169 3.6.3.- AIKFENVSYVYSPGSPLEAIGLDQLNFSLEEGKFIALVGHTGSGKSTLMQHFNALLKPTSGKIEIAGYTITPETGNKGLKDLRRKVSLAFQFSEAQLFENTVLKDVEYGPRNFGFSEDEAREAALKWLKKVGLKDDLIEHSPFDLSGGQMRRVALAGVLAYEPEIICLDEPAAGLDPMGRLEMMQLFKDYQAAGHTVILVTHNMDDVADYADDVLALEHGRLIKHASPKEVFKDSEWLQKHHLAEPRSARFAAKLEAAGLKLPGQPLTMPELADAIKQSLK 5d3m E 3.30 BS01 ANP E 1 F13 N42 G43 G45 K46 S47 T48 K51 Q91 F13 N42 G43 G45 K46 S47 T48 K51 Q91 3.6.3.- GSDNIISFDHVTFTYPDSPRPALSDLSFAIERGSWTALIGHNGSGKSTVSKLINGLLAPDDLDKSSITVDGVKLGADTVWEVREKVGIVFQNPDNQFVGATVSDDVAFGLENRAVPRPEMLKIVAQAVADVGMADYADSEPSNLSGGQKQRVAIAGILAVKPQVIILDESTSMLDPEGKEQILDLVRKIKEDNNLTVISITHDLEEAAGADQVLVLDDGQLLDQGKPEEIFPKVEMLKRIGLDIPFVYRLKQLLKERGIVLPDEIDDDEKLVQSLWQLNS 5d3m F 3.30 BS01 ANP F 1 Y12 T42 G43 S44 G45 K46 S47 D170 Y11 T41 G42 S43 G44 K45 S46 D169 3.6.3.- AIKFENVSYVYSPGSPLEAIGLDQLNFSLEEGKFIALVGHTGSGKSTLMQHFNALLKPTSGKIEIAGYTITPETGNKGLKDLRRKVSLAFQFSEAQLFENTVLKDVEYGPRNFGFSEDEAREAALKWLKKVGLKDDLIEHSPFDLSGGQMRRVALAGVLAYEPEIICLDEPAAGLDPMGRLEMMQLFKDYQAAGHTVILVTHNMDDVADYADDVLALEHGRLIKHASPKEVFKDSEWLQKHHLAEPRSARFAAKLEAAGLKLPGQPLTMPELADAIKQSLK 5d75 A 1.83 BS01 FK5 A 1 Y135 F145 D146 L162 K170 V171 I172 W175 Y198 Q203 A206 I208 F216 Y27 F37 D38 L54 K62 V63 I64 W67 Y90 Q95 A98 I100 F108 5.2.1.8 26749369 PKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSAKKKKNAKPLSFKVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNAKLTFEVELVDIDLEHH 5dno A 1.80 BS01 NUC B 1 N336 R338 V339 S350 Y352 Y392 Y406 I435 K436 T437 Y466 S470 C473 N477 I480 R486 D487 R488 N12 R14 V15 S26 Y28 Y68 Y82 I111 K112 T113 Y142 S146 C149 N153 I156 R162 D163 R164 26673708 MSEHRERISMINPRVVLDENGISHRSRYFIMLCDNETAIAHAKKTSIWAVKKDSSKRISDAYKKASVYFIFVAQQTYNALGYAQVVSDLNSTELPFWSDSSHAGGVRIKWIKTCNLFSAEISEIVSHMDHGSEARDGMEMMYDEGSRLCTLINYAIMKRIGRDR 5e6u A 2.50 BS01 MG A 1 S139 S141 D239 S139 S141 D239 26936951 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVV 5e6u A 2.50 BS02 CA A 1 D443 D445 D447 E449 E451 D435 D437 D439 E441 E443 26936951 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVV 5e6u A 2.50 BS03 CA A 2 D505 I506 N507 D509 L511 D513 D497 I498 N499 D501 L503 D505 26936951 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVV 5e6u B 2.50 BS01 MG B 1 S114 E212 S108 E206 26936951 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNC 5e6u B 2.50 BS02 CA B 1 S116 M117 D119 D120 E325 S110 M111 D113 D114 E319 26936951 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNC 5e6u B 2.50 BS03 CA B 2 D151 N207 D209 P211 E212 D145 N201 D203 P205 E206 26936951 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNC 5edt A 2.45 BS01 HEM A 1 M62 M86 H146 F230 A233 G234 S237 T238 F241 F280 L284 R286 L309 A337 F338 G339 H343 C345 P346 G347 G351 M60 M84 H144 F228 A231 G232 S235 T236 F239 F278 L282 R284 L307 A335 F336 G337 H341 C343 P344 G345 G349 1.14.-.- 27002486 ATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5edt A 2.45 BS02 5MK A 1 T77 V78 S163 A167 F168 A178 N181 W182 D185 V228 T229 G232 T75 V76 S161 A165 F166 A176 N179 W180 D183 V226 T227 G230 1.14.-.- 27002486 ATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5eno C 2.20 BS01 5QG C 1 F136 V139 F178 I277 A279 P326 Y327 M573 F610 V612 F615 F628 F98 V101 F140 I239 A241 P288 Y289 M295 F332 V334 F337 F350 26976576 APPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLTGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSY 5enp C 1.90 BS01 5QF C 1 F136 V139 Q176 F178 G179 I277 A279 P326 Y327 F610 V612 F615 F628 F98 V101 Q138 F140 G141 I239 A241 P288 Y289 F332 V334 F337 F350 26976576 APPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSY 5enq C 1.80 BS01 5QE C 1 F136 V139 F178 I277 A279 P326 Y327 M573 F610 V612 F615 F628 F98 V101 F140 I239 A241 P288 Y289 M295 F332 V334 F337 F350 26976576 APPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSY 5enr C 2.30 BS01 MBX C 1 V139 F178 G179 I277 A279 P326 Y327 F610 V612 F615 F628 V101 F140 G141 I239 A241 P288 Y289 F332 V334 F337 F350 26976576 APPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSY 5ens C 2.80 BS01 RHQ C 1 F136 Q176 F178 G179 I277 A279 P326 F610 F615 F628 F98 Q138 F140 G141 I239 A241 P288 F329 F334 F347 26976576 APPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSY 5ent C 2.50 BS01 MIY C 1 L177 F178 G179 E273 N274 I277 L139 F140 G141 E235 N236 I239 26976576 APPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAITATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSY 5eod A 3.10 BS01 III B 1 K103 I105 N106 N108 S109 T132 A134 S140 H143 I146 L148 L163 K102 I104 N105 N107 S108 T131 A133 S139 H142 I145 L147 L162 3.4.21.27 27006387 CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYKGDSGGPLSCKHNEVWHLVGITSWGEGCERPGVYTNVVEYVDWILEKTQ 5eok A 2.80 BS01 III K 1 K103 N106 Y107 N108 S109 A134 P139 H143 I146 L148 L163 K102 N105 Y106 N107 S108 A133 P138 H142 I145 L147 L162 3.4.21.27 27006387 CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYKGDSGGPLSCKHNEVWHLVGITSWGEGCERPGVYTNVVEYVDWILEKTQ 5es4 A 3.30 BS01 CA A 1 D447 D449 D451 S453 D455 D447 D449 D451 S453 D455 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 A 3.30 BS02 CA A 2 D511 V512 N513 D515 L517 D519 D511 V512 N513 D515 L517 D519 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 A 3.30 BS03 CA A 3 D574 T576 D578 L580 D582 D574 T576 D578 L580 D582 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 A 3.30 BS04 MG A 1 S140 S142 D240 S140 S142 D240 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 B 3.30 BS01 CA B 1 S116 M117 D119 D120 D242 E325 S116 M117 D119 D120 D242 E325 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECV 5es4 C 3.30 BS01 CA C 1 D447 D449 D451 S453 D455 D251 D253 D255 S257 D259 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 C 3.30 BS02 CA C 2 D511 V512 N513 D515 L517 D519 D315 V316 N317 D319 L321 D323 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 C 3.30 BS03 CA C 3 D574 T576 D578 L580 V581 D582 D378 T380 D382 L384 V385 D386 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 D 3.30 BS01 CA D 1 S116 M117 D120 E325 S116 M117 D120 E325 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECV 5es4 E 3.30 BS01 CA E 1 D447 D449 D451 S453 D455 D251 D253 D255 S257 D259 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 E 3.30 BS02 CA E 2 D511 V512 N513 D515 L517 D519 D315 V316 N317 D319 L321 D323 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 E 3.30 BS03 CA E 3 D574 T576 D578 L580 V581 D582 D378 T380 D382 L384 V385 D386 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 F 3.30 BS01 CA F 1 S116 D120 D242 E325 S116 D120 D242 E325 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECV 5es4 G 3.30 BS01 CA G 1 D447 D449 D451 S453 D455 D250 D252 D254 S256 D258 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 G 3.30 BS02 CA G 2 D511 V512 N513 D515 L517 D519 D314 V315 N316 D318 L320 D322 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 G 3.30 BS03 CA G 3 D574 T576 D578 L580 V581 D582 D377 T379 D381 L383 V384 D385 FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEK 5es4 H 3.30 BS01 CA H 1 S116 M117 D120 D242 E325 S116 M117 D120 D242 E325 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECV 5f52 A 1.63 BS01 ASP A 1 G14 T15 A61 S62 E63 G94 T95 D96 A120 G11 T12 A58 S59 E60 G91 T92 D93 A117 3.5.1.1 26855287 LPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5f52 B 1.63 BS01 ASP B 1 G14 T15 A61 S62 E63 G94 T95 D96 A120 G11 T12 A58 S59 E60 G91 T92 D93 A117 3.5.1.1 26855287 LPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5f52 C 1.63 BS01 ASP C 1 G14 T15 A61 S62 E63 G94 T95 D96 A120 G11 T12 A58 S59 E60 G91 T92 D93 A117 3.5.1.1 26855287 LPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5f52 D 1.63 BS01 ASP D 1 G14 T15 A61 S62 E63 G94 T95 D96 A120 G11 T12 A58 S59 E60 G91 T92 D93 A117 3.5.1.1 26855287 LPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5f5f A 3.00 BS01 NUC B 1 R188 R190 R219 S238 K239 T240 Q247 Y250 R251 S253 C254 F255 V257 K259 S264 R14 R16 R45 S64 K65 T66 Q73 Y76 R77 S79 C80 F81 V83 K85 S90 27010430 NPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDKLQT 5f5f C 3.00 BS01 NUC D 1 R188 R190 R219 S238 K239 T240 Q247 Y250 R251 S253 C254 F255 V257 K259 S264 R14 R16 R45 S64 K65 T66 Q73 Y76 R77 S79 C80 F81 V83 K85 S90 27010430 NPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDKLQT 5f5f E 3.00 BS01 NUC F 1 S181 W184 R188 R190 F194 R219 S238 K239 T240 Q247 Y250 R251 S253 C254 F255 V257 K259 S264 S7 W10 R14 R16 F20 R45 S64 K65 T66 Q73 Y76 R77 S79 C80 F81 V83 K85 S90 27010430 NPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDKLQT 5f5f G 3.00 BS01 NUC H 1 R219 K220 S238 K239 T240 Q247 Y250 S253 C254 F255 V257 K259 R42 K43 S61 K62 T63 Q70 Y73 S76 C77 F78 V80 K82 27010430 QLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDKLQ 5f5g A 2.30 BS01 III B 1 F146 H150 N154 S193 W196 F197 G198 G199 S201 S248 M249 A250 F55 H59 N63 S102 W105 F106 G107 G108 S110 S157 M158 A159 3.4.21.105 26805573 RAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVFALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNA 5f5h A 2.23 BS01 NUC C 1 R188 R190 R219 S238 K239 T240 Q247 Y250 R251 S253 C254 F255 V257 K259 R11 R13 R42 S61 K62 T63 Q70 Y73 R74 S76 C77 F78 V80 K82 27010430 QLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDKLQ 5f5h B 2.23 BS01 NUC D 1 R188 R190 R219 S238 K239 T240 Q247 Y250 R251 S253 C254 F255 V257 K259 R15 R17 R46 S65 K66 T67 Q74 Y77 R78 S80 C81 F82 V84 K86 27010430 QNPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDKLQ 5f8w A 1.56 BS01 GAL A 1 E75 H108 P109 K110 G111 G112 V123 H125 D127 H129 E74 H107 P108 K109 G110 G111 V122 H124 D126 H128 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8w A 1.56 BS02 GLA A 1 H16 P17 Y18 G19 G20 V31 H33 D35 H37 N119 H15 P16 Y17 G18 G19 V30 H32 D34 H36 N118 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8w A 1.56 BS03 GLA A 2 N27 H64 P65 Y66 G67 G68 V79 H81 D83 H85 N26 H63 P64 Y65 G66 G67 V78 H80 D82 H84 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8w B 1.56 BS01 GLA B 1 N27 H64 P65 Y66 G67 G68 V79 H81 D83 H85 N26 H63 P64 Y65 G66 G67 V78 H80 D82 H84 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8w B 1.56 BS02 GLA B 2 E75 H108 P109 K110 G111 G112 V123 H125 D127 H129 E74 H107 P108 K109 G110 G111 V122 H124 D126 H128 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8w B 1.56 BS03 GLA B 3 H16 P17 Y18 G19 G20 V31 H33 D35 H37 N119 H15 P16 Y17 G18 G19 V30 H32 D34 H36 N118 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8y A 1.70 BS01 X6X A 1 N27 H64 P65 Y66 G67 G68 V79 H81 D83 H85 N26 H63 P64 Y65 G66 G67 V78 H80 D82 H84 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8y A 1.70 BS02 X6X A 2 E75 H108 P109 K110 G111 G112 V123 H125 D127 H129 E74 H107 P108 K109 G110 G111 V122 H124 D126 H128 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8y A 1.70 BS03 X6X A 3 H16 P17 Y18 G19 G20 H33 D35 H37 N119 H15 P16 Y17 G18 G19 H32 D34 H36 N118 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8y B 1.70 BS01 X6X B 1 E75 H108 P109 K110 G111 G112 V123 H125 D127 H129 E74 H107 P108 K109 G110 G111 V122 H124 D126 H128 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8y B 1.70 BS02 X6X B 2 H16 P17 Y18 G19 G20 H33 D35 H37 N119 H15 P16 Y17 G18 G19 H32 D34 H36 N118 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f8y B 1.70 BS03 X6X B 3 N27 H64 P65 Y66 G67 G68 V79 H81 D83 H85 N26 H63 P64 Y65 G66 G67 V78 H80 D82 H84 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f90 A 1.64 BS01 GLA A 1 H16 P17 Y18 G19 G20 H33 D35 H37 N119 H16 P17 Y18 G19 G20 H33 D35 H37 N119 27010847 MTTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f90 A 1.64 BS02 GLA A 2 N27 H64 P65 Y66 G67 G68 H81 D83 H85 N27 H64 P65 Y66 G67 G68 H81 D83 H85 27010847 MTTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f90 A 1.64 BS03 GAL A 1 N27 Y66 N27 Y66 27010847 MTTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f90 B 1.64 BS01 GLA B 1 H16 P17 Y18 G19 G20 H33 D35 H37 N119 H15 P16 Y17 G18 G19 H32 D34 H36 N118 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f90 B 1.64 BS02 GLA B 2 N27 H64 P65 Y66 G67 G68 H81 D83 H85 N26 H63 P64 Y65 G66 G67 H80 D82 H84 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5f90 B 1.64 BS03 GLA B 3 E75 H108 P109 K110 G111 G112 H125 D127 H129 E74 H107 P108 K109 G110 G111 H124 D126 H128 27010847 TTFLIKHKASGKFLHPYGGSSNPANNTKLVLHSDIHERMYFQFDVVDERWGYIKHVASGKIVHPYGGQANPPNETNMVLHQDRHDRALFAMDFFNDNIMHKGGKYIHPKGGSPNPPNNTETVIHGDKHAAMEFIFVSPKNKDKRVLVYA 5fep A 1.45 BS01 SF4 A 1 C63 K65 C67 Y69 C70 R73 G109 C62 K64 C66 Y68 C69 R72 G108 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fep A 1.45 BS02 SAM A 1 Y69 C70 S108 S136 G138 R159 E161 R180 M199 P229 I231 Y303 L305 Y306 Y68 C69 S107 S135 G137 R158 E160 R179 M198 P228 I230 Y302 L304 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fep A 1.45 BS03 41K A 1 Q107 R159 T268 T269 A270 M291 Y306 Q106 R158 T267 T268 A269 M290 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fes A 1.27 BS01 SF4 A 1 C63 K65 C67 Y69 C70 R73 G109 C62 K64 C66 Y68 C69 R72 G108 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fes A 1.27 BS02 SAM A 1 Y69 C70 S108 S136 G138 R159 E161 R180 M199 P229 I231 Y303 L305 Y306 Y68 C69 S107 S135 G137 R158 E160 R179 M198 P228 I230 Y302 L304 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fes A 1.27 BS03 9SE A 1 I56 Q107 R159 T268 T269 A270 M291 Y306 I55 Q106 R158 T267 T268 A269 M290 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5few A 1.17 BS01 SF4 A 1 C63 K65 C67 Y69 C70 R73 G109 C62 K64 C66 Y68 C69 R72 G108 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5few A 1.17 BS02 MET A 1 Q107 S108 S136 G138 R180 Y303 L305 Q106 S107 S135 G137 R179 Y302 L304 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5few A 1.17 BS03 5X8 A 1 Y69 Q107 R159 E161 M199 P229 I231 T268 T269 A270 Y306 Y68 Q106 R158 E160 M198 P228 I230 T267 T268 A269 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5few A 1.17 BS04 SAH A 1 Y69 Q107 S108 S136 G138 R159 E161 R180 M199 P229 I231 Y303 L305 Y306 Y68 Q106 S107 S135 G137 R158 E160 R179 M198 P228 I230 Y302 L304 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5few A 1.17 BS05 41K A 1 I56 Q107 L157 R159 T268 T269 A270 M291 Y306 I55 Q106 L156 R158 T267 T268 A269 M290 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fex A 1.32 BS01 SF4 A 1 C63 K65 C67 Y69 C70 L72 R73 G109 C62 K64 C66 Y68 C69 L71 R72 G108 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fex A 1.32 BS02 MET A 1 Q107 S108 S136 G138 R180 Y303 L305 Q106 S107 S135 G137 R179 Y302 L304 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fex A 1.32 BS03 SEC A 1 Q107 R159 T268 T269 A270 Y306 Q106 R158 T267 T268 A269 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fez A 1.35 BS01 SFS A 1 C63 K65 C67 Y69 C70 L72 R73 G109 E110 C62 K64 C66 Y68 C69 L71 R72 G108 E109 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fez A 1.35 BS02 5AD A 1 Y69 R159 E161 M199 P229 I231 L305 Y306 Y68 R158 E160 M198 P228 I230 L304 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fez A 1.35 BS03 MET A 1 S108 S136 G138 R180 Y303 S107 S135 G137 R179 Y302 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fez A 1.35 BS04 9SE A 1 Q107 R159 T268 T269 A270 M291 Y306 Q106 R158 T267 T268 A269 M290 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5ff0 A 1.49 BS01 SFS A 1 C63 K65 C67 Y69 C70 L72 R73 G109 E110 C62 K64 C66 Y68 C69 L71 R72 G108 E109 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5ff0 A 1.49 BS02 MET A 1 Q107 S108 S136 G138 R180 Y303 L305 Q106 S107 S135 G137 R179 Y302 L304 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5ff0 A 1.49 BS03 5X8 A 1 Y69 Q107 R159 E161 M199 P229 I231 T268 T269 A270 L305 Y306 Y68 Q106 R158 E160 M198 P228 I230 T267 T268 A269 L304 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5ff2 A 1.47 BS01 SF4 A 1 C63 K65 C67 Y69 C70 L72 R73 G109 C63 K65 C67 Y69 C70 L72 R73 G109 1.8.-.- MTGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKICVFEKDTACIPCVMKMIELLGRKPGRDWGGRKRVFET 5ff2 A 1.47 BS02 SAH A 1 Y69 Q107 S108 R159 E161 R180 M199 P229 I231 Y303 L305 Y306 Y69 Q107 S108 R159 E161 R180 M199 P229 I231 Y303 L305 Y306 1.8.-.- MTGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKICVFEKDTACIPCVMKMIELLGRKPGRDWGGRKRVFET 5ff2 A 1.47 BS03 5XB A 1 Q107 L157 R159 G226 T268 T269 A270 M291 Y306 Q107 L157 R159 G226 T268 T269 A270 M291 Y306 1.8.-.- MTGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKICVFEKDTACIPCVMKMIELLGRKPGRDWGGRKRVFET 5ff3 A 1.18 BS01 SF4 A 1 C63 K65 C67 Y69 C70 L72 R73 G109 C63 K65 C67 Y69 C70 L72 R73 G109 1.8.-.- MTGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKICVFEKDTACIPCVMKMIELLGRKPGRDWGGRKRVFET 5ff3 A 1.18 BS02 FES A 1 R279 C311 E314 C319 C322 V323 R279 C311 E314 C319 C322 V323 1.8.-.- MTGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKICVFEKDTACIPCVMKMIELLGRKPGRDWGGRKRVFET 5ff3 A 1.18 BS03 SAH A 1 Y69 Q107 S108 S136 R159 E161 R180 M199 P229 I231 Y303 L305 Y306 Y69 Q107 S108 S136 R159 E161 R180 M199 P229 I231 Y303 L305 Y306 1.8.-.- MTGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKICVFEKDTACIPCVMKMIELLGRKPGRDWGGRKRVFET 5ff3 A 1.18 BS04 PRS A 1 Q107 R159 T268 T269 A270 Y306 Q107 R159 T268 T269 A270 Y306 1.8.-.- MTGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKICVFEKDTACIPCVMKMIELLGRKPGRDWGGRKRVFET 5ff4 A 1.35 BS01 SFS A 1 C63 K65 C67 Y69 C70 L72 R73 G109 E110 C62 K64 C66 Y68 C69 L71 R72 G108 E109 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5ff4 A 1.35 BS02 SAH A 1 Y69 Q107 S108 S136 R159 E161 R180 M199 P229 I231 Y303 L305 Y306 Y68 Q106 S107 S135 R158 E160 R179 M198 P228 I230 Y302 L304 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5ff4 A 1.35 BS03 5ZZ A 1 I56 Q107 R159 G226 T268 T269 A270 M291 L305 Y306 I55 Q106 R158 G225 T267 T268 A269 M290 L304 Y305 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5ff4 A 1.35 BS04 SE A 1 E139 W140 Y145 C183 E138 W139 Y144 C182 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5ff4 A 1.35 BS05 SE A 2 W140 Y145 C183 W139 Y144 C182 1.8.-.- TGREILEKLERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIEFSNVCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARLAVQFGAKTIVLQSGEDPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEAGADRYLLRHETANPVLHRKLRPDTSFENRLNCLLTLKELGYETGAGSMVGLPGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRILLPDSNIPATTAMGTIVPGGREITLRCGANVIMPNWTPSPYRQLYQLYPGKISVFEKDTASIPSVMKMIELLGRKPGRDWGGRKRVFET 5fjm A 2.00 BS01 FAD A 1 I61 G62 G64 I65 Q66 L84 E85 K86 E92 Q93 S94 A97 Y98 S99 Q100 A227 V228 A256 G257 G258 W260 L279 Q281 F370 A410 V412 T437 V438 W439 G440 M441 T442 I34 G35 G37 I38 Q39 L57 E58 K59 E65 Q66 S67 A70 Y71 S72 Q73 A200 V201 A229 G230 G231 W233 L252 Q254 F343 A383 V385 T410 V411 W412 G413 M414 T415 MVRRDGKFVESKSRALFVESTEGALPSESDVVIIGGGIQGIMTAINLAERGMSVTILEKGEVAGEQSGRAYSQIISYQTSPEIFPLHHYGKILWRGMNEKIGADTSYRTQGRVEALADEKALDRAQEWIKTAKETAGFDVPLNTRIIKGEELSNRLVGAQTPWTVAAFEEDSGSVDPETGTPTLARYAKQIGVKIYTHCAVRGIETAGGKISDVVTEKGAIRTSNVVLAGGIWSRLFMGNMGVDLPTLNVYLSQQRVSGVPGAPRGNVHLPNGIHFREQADGTYAVAPRIFTSSIVKDSFLLGPKFMHLLGGGELPLEFSIGEDLFNSFKMPTSWKLDEKSPFEQYRIATATQNTEHLDAVFQRMKTEFPVFEKSQIVERWGAVVSPTFDELPIISEVKEYPGLVINTATVWGMTEGPAAGEVTADIVTGKKPVIDPTPFSLDRFKK 5fjm B 2.00 BS01 FAD B 1 I61 G62 G64 I65 Q66 L84 E85 K86 E92 Q93 S94 A97 Y98 S99 Q100 A227 V228 A256 G257 G258 W260 L279 Q281 F370 A410 V412 T437 V438 W439 G440 M441 T442 I34 G35 G37 I38 Q39 L57 E58 K59 E65 Q66 S67 A70 Y71 S72 Q73 A200 V201 A229 G230 G231 W233 L252 Q254 F343 A383 V385 T410 V411 W412 G413 M414 T415 MVRRDGKFVESKSRALFVESTEGALPSESDVVIIGGGIQGIMTAINLAERGMSVTILEKGEVAGEQSGRAYSQIISYQTSPEIFPLHHYGKILWRGMNEKIGADTSYRTQGRVEALADEKALDRAQEWIKTAKETAGFDVPLNTRIIKGEELSNRLVGAQTPWTVAAFEEDSGSVDPETGTPTLARYAKQIGVKIYTHCAVRGIETAGGKISDVVTEKGAIRTSNVVLAGGIWSRLFMGNMGVDLPTLNVYLSQQRVSGVPGAPRGNVHLPNGIHFREQADGTYAVAPRIFTSSIVKDSFLLGPKFMHLLGGGELPLEFSIGEDLFNSFKMPTSWKLDEKSPFEQYRIATATQNTEHLDAVFQRMKTEFPVFEKSQIVERWGAVVSPTFDELPIISEVKEYPGLVINTATVWGMTEGPAAGEVTADIVTGKKPVIDPTPFSLDRFKK 5fjn A 1.75 BS01 FAD A 1 I61 G62 G64 I65 Q66 L84 E85 K86 E92 Q93 S94 A97 Y98 S99 Q100 A227 V228 A256 G257 G258 W260 L279 Q281 F370 A410 V412 T437 V438 W439 G440 M441 T442 I34 G35 G37 I38 Q39 L57 E58 K59 E65 Q66 S67 A70 Y71 S72 Q73 A200 V201 A229 G230 G231 W233 L252 Q254 F343 A383 V385 T410 V411 W412 G413 M414 T415 MVRRDGKFVESKSRALFVESTEGALPSESDVVIIGGGIQGIMTAINLAERGMSVTILEKGEVAGEQSGRAYSQIISYQTSPEIFPLHHYGKILWRGMNEKIGADTSYRTQGRVEALADEKALDRAQEWIKTAKETAGFDVPLNTRIIKGEELSNRLVGAQTPWTVAAFEEDSGSVDPETGTPTLARYAKQIGVKIYTHCAVRGIETAGGKISDVVTEKGAIRTSNVVLAGGIWSRLFMGNMGVDLPTLNVYLSQQRVSGVPGAPRGNVHLPNGIHFREQADGTYAVAPRIFTSSIVKDSFLLGPKFMHLLGGGELPLEFSIGEDLFNSFKMPTSWKLDEKSPFEQYRIATATQNTEHLDAVFQRMKTEFPVFEKSQIVERWGAVVSPTFDELPIISEVKEYPGLVINTATVWGMTEGPAAGEVTADIVTGKKPVIDPTPFSLDRFKK 5fjn A 1.75 BS02 BE2 A 1 Y98 Q100 L279 R316 V438 W439 Y71 Q73 L252 R289 V411 W412 MVRRDGKFVESKSRALFVESTEGALPSESDVVIIGGGIQGIMTAINLAERGMSVTILEKGEVAGEQSGRAYSQIISYQTSPEIFPLHHYGKILWRGMNEKIGADTSYRTQGRVEALADEKALDRAQEWIKTAKETAGFDVPLNTRIIKGEELSNRLVGAQTPWTVAAFEEDSGSVDPETGTPTLARYAKQIGVKIYTHCAVRGIETAGGKISDVVTEKGAIRTSNVVLAGGIWSRLFMGNMGVDLPTLNVYLSQQRVSGVPGAPRGNVHLPNGIHFREQADGTYAVAPRIFTSSIVKDSFLLGPKFMHLLGGGELPLEFSIGEDLFNSFKMPTSWKLDEKSPFEQYRIATATQNTEHLDAVFQRMKTEFPVFEKSQIVERWGAVVSPTFDELPIISEVKEYPGLVINTATVWGMTEGPAAGEVTADIVTGKKPVIDPTPFSLDRFKK 5fjn B 1.75 BS01 FAD B 1 I61 G62 G64 I65 Q66 L84 E85 K86 E92 Q93 S94 A97 Y98 S99 Q100 A227 V228 A256 G257 G258 W260 L279 Q281 F370 A410 V412 T437 V438 W439 G440 M441 T442 I34 G35 G37 I38 Q39 L57 E58 K59 E65 Q66 S67 A70 Y71 S72 Q73 A200 V201 A229 G230 G231 W233 L252 Q254 F343 A383 V385 T410 V411 W412 G413 M414 T415 MVRRDGKFVESKSRALFVESTEGALPSESDVVIIGGGIQGIMTAINLAERGMSVTILEKGEVAGEQSGRAYSQIISYQTSPEIFPLHHYGKILWRGMNEKIGADTSYRTQGRVEALADEKALDRAQEWIKTAKETAGFDVPLNTRIIKGEELSNRLVGAQTPWTVAAFEEDSGSVDPETGTPTLARYAKQIGVKIYTHCAVRGIETAGGKISDVVTEKGAIRTSNVVLAGGIWSRLFMGNMGVDLPTLNVYLSQQRVSGVPGAPRGNVHLPNGIHFREQADGTYAVAPRIFTSSIVKDSFLLGPKFMHLLGGGELPLEFSIGEDLFNSFKMPTSWKLDEKSPFEQYRIATATQNTEHLDAVFQRMKTEFPVFEKSQIVERWGAVVSPTFDELPIISEVKEYPGLVINTATVWGMTEGPAAGEVTADIVTGKKPVIDPTPFSLDRFKK 5fjn B 1.75 BS02 BE2 B 1 Y98 Q100 L279 R316 V438 W439 Y71 Q73 L252 R289 V411 W412 MVRRDGKFVESKSRALFVESTEGALPSESDVVIIGGGIQGIMTAINLAERGMSVTILEKGEVAGEQSGRAYSQIISYQTSPEIFPLHHYGKILWRGMNEKIGADTSYRTQGRVEALADEKALDRAQEWIKTAKETAGFDVPLNTRIIKGEELSNRLVGAQTPWTVAAFEEDSGSVDPETGTPTLARYAKQIGVKIYTHCAVRGIETAGGKISDVVTEKGAIRTSNVVLAGGIWSRLFMGNMGVDLPTLNVYLSQQRVSGVPGAPRGNVHLPNGIHFREQADGTYAVAPRIFTSSIVKDSFLLGPKFMHLLGGGELPLEFSIGEDLFNSFKMPTSWKLDEKSPFEQYRIATATQNTEHLDAVFQRMKTEFPVFEKSQIVERWGAVVSPTFDELPIISEVKEYPGLVINTATVWGMTEGPAAGEVTADIVTGKKPVIDPTPFSLDRFKK 5fkk A 1.75 BS01 TDC B 1 L174 M177 L169 M172 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNAAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDPDENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 5fkk B 1.75 BS01 TDC B 1 H64 S67 A82 F86 H100 R104 P105 V113 Q116 L131 I134 H63 S66 A81 F85 H99 R103 P104 V112 Q115 L130 I133 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNAAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 5fkl A 1.90 BS01 TDC A 1 H64 S67 N82 F86 R104 P105 V113 Q116 L117 I134 S138 H63 S66 N81 F85 R103 P104 V112 Q115 L116 I133 S137 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVALGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 5fkm A 1.63 BS01 TDC A 1 H64 S67 N82 F86 H100 R104 P105 V113 Q116 I134 S138 H63 S66 N81 F85 H99 R103 P104 V112 Q115 I133 S137 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGARPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPANLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 5fkn A 1.80 BS01 TDC A 1 H64 S67 N82 F86 H100 R104 P105 V113 Q116 I134 S138 H63 S66 N81 F85 H99 R103 P104 V112 Q115 I133 S137 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGARPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTNLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 5fkn B 1.80 BS01 TDC A 1 L170 L174 M177 L165 L169 M172 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGARPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPANLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 5fkn B 1.80 BS02 TDC B 1 H64 S67 N82 F86 H100 R104 P105 T112 V113 Q116 I134 H63 S66 N81 F85 H99 R103 P104 T111 V112 Q115 I133 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGARPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPANLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 5fko A 1.85 BS01 TDC A 1 H64 S67 N82 F86 H100 R104 P105 V113 Q116 I134 S138 H63 S66 N81 F85 H99 R103 P104 V112 Q115 I133 S137 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLAQQEHTAALNLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 5fob A 2.60 BS01 FUC A 1 V43 M83 G84 N85 A503 G504 V21 M61 G62 N63 A481 G482 27013439 SPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQ 5fqu B 2.74 BS01 AZI B 1 E199 I200 E138 I139 27012424 RPKIGLVLSGGAARGLAHIGVLKALDEQGIQIDAIAGTSMGAVVGGLYASGYTPAELERIALEMDWQLGVIQGQNLAMVLESLLVHTSDNRDFDKLAIPFRAVSTDIATGEKVVFRKGHLPQAIRASMSIPAVFAPVEIRLLVDGGMVDNIPVDVARDMGVDVVIVVDIGNPLRDRKDLSTVLDVMNQSITLMTRKNSEAQLATLKPGDVLIQPPLSGYGTTDFGRVPQLIDAGYRATTVLAARLAEL 5frw A 2.10 BS01 IPH A 1 G98 P99 H102 V110 F128 W130 Y157 G91 P92 H95 V103 F121 W123 Y150 FSATMRDGLSNLARRLRFAMKEGSIWLGEQRMILLHTAALGALRKELVDTLGMERARGLFMRMGFHSGVRDAELAKTMRSGHSDFGMLEMGPCLHTIEGVVRVTPLTVDINIAAGVYHGEFLWEDSFEGDVHRQMFGVAQAPVCWMQIGYATGYTSALMGKTILYRELECVGCGHPHCRILGKPLEQWEDGEAELALYQPD 5frw A 2.10 BS02 ZN A 1 C151 E174 C177 C185 C144 E167 C170 C178 FSATMRDGLSNLARRLRFAMKEGSIWLGEQRMILLHTAALGALRKELVDTLGMERARGLFMRMGFHSGVRDAELAKTMRSGHSDFGMLEMGPCLHTIEGVVRVTPLTVDINIAAGVYHGEFLWEDSFEGDVHRQMFGVAQAPVCWMQIGYATGYTSALMGKTILYRELECVGCGHPHCRILGKPLEQWEDGEAELALYQPD 5frw B 2.10 BS01 IPH B 1 G98 P99 H102 V110 F128 W130 Y157 A158 G88 P89 H92 V100 F118 W120 Y147 A148 TMRDGLSNLARRLRFAMKEGSIWLGEQRMILLHTAALGALRKELVDTLGMERARGLFMRMGFHSGVRDAELAKTMRSGHSDFGMLEMGPCLHTIEGVVRVTPLTVDINIAAGVYHGEFLWEDSFEGDVHRQMFGVAQAPVCWMQIGYATGYTSALMGKTILYRELECVGCGHPHCRILGKPLEQWEDGEAELALYQPD 5frw B 2.10 BS02 ZN B 1 C151 E174 C177 C185 C141 E164 C167 C175 TMRDGLSNLARRLRFAMKEGSIWLGEQRMILLHTAALGALRKELVDTLGMERARGLFMRMGFHSGVRDAELAKTMRSGHSDFGMLEMGPCLHTIEGVVRVTPLTVDINIAAGVYHGEFLWEDSFEGDVHRQMFGVAQAPVCWMQIGYATGYTSALMGKTILYRELECVGCGHPHCRILGKPLEQWEDGEAELALYQPD 5fsg A 3.21 BS01 MTT A 1 N-360 D-358 K-357 K-330 E-328 E-327 W-310 A-309 D-307 R-306 E-261 E-219 P-218 Y-217 F-216 W-142 M-42 W-32 Y-31 R-28 N13 D15 K16 K43 E45 E46 W63 A64 D66 R67 E112 E154 P155 Y156 F157 W231 M331 W341 Y342 R345 26923588 MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAGSAQTNAAATGQTADWLSIIVYLTSFVVPILLKALYMLTTRGRTRIRFKRKPKHLYVSLPNANSSMKAEEITPGRYRTAVCGLYPAQIKARQMISPVMSVIGFLALAKDWSDRIEQWLIEPCKLLPDTAAVSLGGPATNRDYLRQRQVALGNMETKESKAIRQHAEAAGCSMIEDIESPSSIWVFAGAPDRCPPTCLFIAGIAELGAFFSILQDMRNTIMASKTVGSFYQSYLRRTQSMGIQLDQRIIVLFMVAWGKEAVDNFHLGDDMDPELRTLAQSLIDVKVKEISNQEPLKLL 5fto A 2.22 BS01 YMX A 1 L1122 G1123 F1127 V1130 A1148 L1196 E1197 M1199 A1200 G1201 G1202 D1203 R1253 N1254 L1256 G1269 D1270 L30 G31 F35 V38 A52 L100 E101 M103 A104 G105 G106 D107 R157 N158 L160 G173 D174 2.7.10.1 27003761 GPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEY 5ftq A 1.70 BS01 U4W A 1 L1122 G1123 F1127 V1130 A1148 L1196 E1197 L1198 M1199 A1200 G1201 G1202 D1203 R1253 N1254 L1256 G1269 L30 G31 F35 V38 A49 L97 E98 L99 M100 A101 G102 G103 D104 R154 N155 L157 G170 2.7.10.1 27003761 GPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRCAMLPVKWMPPEAFEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEY 5fur A 8.50 BS01 NUC E 1 V169 L212 F214 S216 K218 V220 Q256 N257 L287 F288 I292 R294 R299 V301 L303 T313 V11 L54 F56 S58 K60 V62 Q98 N99 L129 F130 I134 R136 R141 V143 L145 T155 27007846 SGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKT 5fur A 8.50 BS02 NUC F 1 Q166 N167 R196 F197 R203 T210 L212 T222 V259 F288 P289 L303 F305 S307 K309 V311 Q8 N9 R38 F39 R45 T52 L54 T64 V101 F130 P131 L145 F147 S149 K151 V153 27007846 SGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKT 5fur C 8.50 BS01 NUC F 1 R344 K346 K369 R15 K17 K40 27007846 DTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW 5fur G 8.50 BS01 NUC E 1 R875 T876 G877 R267 T268 G269 2.3.1.48,2.7.11.1 27007846 IIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTD 5fur G 8.50 BS02 NUC F 1 K818 E860 R864 F873 D879 W883 K210 E252 R256 F265 D271 W275 2.3.1.48,2.7.11.1 27007846 IIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTD 5fur I 8.50 BS01 NUC F 1 N542 C592 N479 C529 27007846 KLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAVDLY 5fur I 8.50 BS02 III L 1 K730 P733 Y781 N782 D783 N784 R827 L828 E831 L837 N838 K667 P670 Y718 N719 D720 N721 R764 L765 E768 L774 N775 27007846 KLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAVDLY 5fur J 8.50 BS01 III L 1 E219 Q220 L222 Y223 E226 A237 K238 E241 T248 D249 P250 G251 E3 Q4 L6 Y7 E10 A21 K22 E25 T32 D33 P34 G35 27007846 SVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLA 5fw4 A 1.80 BS01 HEM A 1 N197 Q201 I202 G204 T205 A206 I243 M245 R264 H299 V300 A303 P305 M313 R315 L334 F336 F347 V350 Q351 L361 I365 H367 N188 Q192 I193 G195 T196 A197 I234 M236 R255 H276 V277 A280 P282 M290 R292 L311 F313 F324 V327 Q328 L338 I342 H344 1.11.1.19 26901432 ASPKAEQRLRMAAQRADATAAPQPGISGPAPAFVHVIALDLAEEARKNPDTARDSAAAALRSWTELAARLHEESPHDIAEGAASAGLLPASLMVTVGIGGSLLSAIDAEDRRPDALADLPEFSTDDLHPRWCGGDFMLQVGAEDPMVLTAAVEELVAAAADATAVRWSLRGFRRTAAAARDPDATPRNLMGQIDGTANPAQDHPLFDRTITARPADNPAHAWMDGGSYLVVRRIRMLLTEWRKLDVAARERVIGRRLDTGAPLGSRNETLIPENAHVRLASPENNLGARMFRRGYSYDQGWRDDGVRDAGLLFMAWQGDPATGFIPVQRSLADQGDALNRYIRHEGSALFAVPAAREGRYLGQDLIEG 5fw4 A 1.80 BS02 OXY A 1 D203 R315 F336 D194 R292 F313 1.11.1.19 26901432 ASPKAEQRLRMAAQRADATAAPQPGISGPAPAFVHVIALDLAEEARKNPDTARDSAAAALRSWTELAARLHEESPHDIAEGAASAGLLPASLMVTVGIGGSLLSAIDAEDRRPDALADLPEFSTDDLHPRWCGGDFMLQVGAEDPMVLTAAVEELVAAAADATAVRWSLRGFRRTAAAARDPDATPRNLMGQIDGTANPAQDHPLFDRTITARPADNPAHAWMDGGSYLVVRRIRMLLTEWRKLDVAARERVIGRRLDTGAPLGSRNETLIPENAHVRLASPENNLGARMFRRGYSYDQGWRDDGVRDAGLLFMAWQGDPATGFIPVQRSLADQGDALNRYIRHEGSALFAVPAAREGRYLGQDLIEG 5fw4 B 1.80 BS01 HEM B 1 N197 Q201 I202 G204 T205 A206 I243 M245 R264 H299 V300 A303 S304 P305 M313 R315 L334 F336 F347 V350 Q351 L361 I365 H367 N188 Q192 I193 G195 T196 A197 I234 M236 R255 H276 V277 A280 S281 P282 M290 R292 L311 F313 F324 V327 Q328 L338 I342 H344 1.11.1.19 26901432 ASPKAEQRLRMAAQRADATAAPQPGISGPAPAFVHVIALDLAEEARKNPDTARDSAAAALRSWTELAARLHEESPHDIAEGAASAGLLPASLMVTVGIGGSLLSAIDAEDRRPDALADLPEFSTDDLHPRWCGGDFMLQVGAEDPMVLTAAVEELVAAAADATAVRWSLRGFRRTAAAARDPDATPRNLMGQIDGTANPAQDHPLFDRTITARPADNPAHAWMDGGSYLVVRRIRMLLTEWRKLDVAARERVIGRRLDTGAPLGSRNETLIPENAHVRLASPENNLGARMFRRGYSYDQGWRDDGVRDAGLLFMAWQGDPATGFIPVQRSLADQGDALNRYIRHEGSALFAVPAAREGRYLGQDLIEG 5fw4 B 1.80 BS02 OXY B 1 D203 R315 F336 D194 R292 F313 1.11.1.19 26901432 ASPKAEQRLRMAAQRADATAAPQPGISGPAPAFVHVIALDLAEEARKNPDTARDSAAAALRSWTELAARLHEESPHDIAEGAASAGLLPASLMVTVGIGGSLLSAIDAEDRRPDALADLPEFSTDDLHPRWCGGDFMLQVGAEDPMVLTAAVEELVAAAADATAVRWSLRGFRRTAAAARDPDATPRNLMGQIDGTANPAQDHPLFDRTITARPADNPAHAWMDGGSYLVVRRIRMLLTEWRKLDVAARERVIGRRLDTGAPLGSRNETLIPENAHVRLASPENNLGARMFRRGYSYDQGWRDDGVRDAGLLFMAWQGDPATGFIPVQRSLADQGDALNRYIRHEGSALFAVPAAREGRYLGQDLIEG 5fwe A 2.05 BS01 III C 1 E169 G170 Y175 Y177 E190 S288 N290 E163 G164 Y169 Y171 E184 S282 N284 1.14.11.- TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 5fwe A 2.05 BS02 ZN A 1 C234 H240 C306 C308 C228 H234 C300 C302 1.14.11.- TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 5fwe B 2.05 BS01 III D 1 A134 D135 E169 G170 V171 Y175 Y177 S288 T289 V313 A132 D133 E167 G168 V169 Y173 Y175 S286 T287 V311 1.14.11.- SESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLK 5fwe B 2.05 BS02 ZN B 1 C234 H240 C306 C308 C232 H238 C304 C306 1.14.11.- SESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLK 5fz0 A 2.42 BS01 ZN A 1 C692 C695 C715 H718 C392 C395 C415 H418 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fz0 A 2.42 BS02 ZN A 2 C706 C708 C723 C725 C406 C408 C423 C425 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fz0 A 2.42 BS03 MN A 1 H499 E501 H587 H199 E201 H287 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fz0 A 2.42 BS04 DJ6 A 1 R86 R98 V99 Y425 A427 W486 Y488 S495 F496 H499 W519 H587 R63 R75 V76 Y127 A129 W186 Y188 S195 F196 H199 W219 H287 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fzk A 2.05 BS01 ZN A 1 C692 C695 C715 H718 C392 C395 C415 H418 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fzk A 2.05 BS02 MN A 1 H499 E501 H587 H200 E202 H288 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fzk A 2.05 BS03 NRW A 1 Q88 Q96 Y425 Y488 F496 C497 H499 W519 Q65 Q73 Y128 Y189 F197 C198 H200 W220 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fzk A 2.05 BS04 DMS A 1 W486 Y488 S507 A599 V600 N601 W187 Y189 S208 A300 V301 N302 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fzk A 2.05 BS05 DMS A 2 I500 W504 Y618 L621 I201 W205 Y318 L321 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fzl A 2.55 BS01 ZN A 1 C692 C695 C715 H718 C391 C394 C414 H417 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fzl A 2.55 BS02 MN A 1 H499 E501 H587 H200 E202 H286 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5fzl A 2.55 BS03 UOI A 1 Y425 Y488 S494 S495 F496 H499 K517 W519 H587 N591 Y128 Y189 S195 S196 F197 H200 K218 W220 H286 N290 1.14.11.- SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE 5hdj A 1.89 BS01 FMN A 1 H11 R12 S13 R15 Q67 Y69 C133 Y134 I135 G136 G137 K173 R175 H10 R11 S12 R14 Q66 Y68 C132 Y133 I134 G135 G136 K172 R174 27005432 NSVIETILNHRSIRKYEDKPLSEEQIQTIVESAQAASTSSYIQAYSIIGVKDKETKRKLAQLAGNQPYVETNGHFFVFCADFHRHDVIAEMEKKDLSTALESTEQFMVAIIDVALAAQNATLAAESMGLGACYIGGLRNELEEVSKLLKLPHHVIPLFGLTVGHPAGITDKKPRLPFKHVYHEETYEPNDEQTKKELTAYNEEISAYYNERTNGKRQDTWTGQMAEMLSNPKRMYMKEFVEKQGFNK 5hdj A 1.89 BS02 FMN B 1 S38 T39 S40 I112 L116 S37 T38 S39 I111 L115 27005432 NSVIETILNHRSIRKYEDKPLSEEQIQTIVESAQAASTSSYIQAYSIIGVKDKETKRKLAQLAGNQPYVETNGHFFVFCADFHRHDVIAEMEKKDLSTALESTEQFMVAIIDVALAAQNATLAAESMGLGACYIGGLRNELEEVSKLLKLPHHVIPLFGLTVGHPAGITDKKPRLPFKHVYHEETYEPNDEQTKKELTAYNEEISAYYNERTNGKRQDTWTGQMAEMLSNPKRMYMKEFVEKQGFNK 5hdj B 1.89 BS01 FMN A 1 S38 T39 S40 I112 L116 S38 T39 S40 I112 L116 27005432 MNSVIETILNHRSIRKYEDKPLSEEQIQTIVESAQAASTSSYIQAYSIIGVKDKETKRKLAQLAGNQPYVETNGHFFVFCADFHRHDVIAEMEKKDLSTALESTEQFMVAIIDVALAAQNATLAAESMGLGACYIGGLRNELEEVSKLLKLPHHVIPLFGLTVGHPAGITDKKPRLPFKHVYHEETYEPNDEQTKKELTAYNEEISAYYNERTNGKRQDTWTGQMAEMLSNPKRMYMKEFVEKQGFNK 5hdj B 1.89 BS02 FMN B 1 H11 R12 S13 R15 Q67 Y69 C133 Y134 I135 G136 G137 K173 R175 H11 R12 S13 R15 Q67 Y69 C133 Y134 I135 G136 G137 K173 R175 27005432 MNSVIETILNHRSIRKYEDKPLSEEQIQTIVESAQAASTSSYIQAYSIIGVKDKETKRKLAQLAGNQPYVETNGHFFVFCADFHRHDVIAEMEKKDLSTALESTEQFMVAIIDVALAAQNATLAAESMGLGACYIGGLRNELEEVSKLLKLPHHVIPLFGLTVGHPAGITDKKPRLPFKHVYHEETYEPNDEQTKKELTAYNEEISAYYNERTNGKRQDTWTGQMAEMLSNPKRMYMKEFVEKQGFNK 5hei A 2.84 BS01 FMN A 1 H11 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 H11 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei A 2.84 BS02 FMN B 1 A38 S39 S40 N42 T111 I115 A38 S39 S40 N42 T111 I115 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei B 2.84 BS01 FMN A 1 A38 S39 S40 N42 I115 A38 S39 S40 N42 I115 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei B 2.84 BS02 FMN B 1 H11 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 H11 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei C 2.84 BS01 FMN C 1 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 H10 R11 S12 R14 Q66 W68 V131 P132 G134 G135 K171 R173 27005432 NEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei C 2.84 BS02 FMN D 1 A38 S39 S40 N42 I115 A37 S38 S39 N41 I114 27005432 NEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei D 2.84 BS01 FMN C 1 A38 S39 S40 N42 I115 A38 S39 S40 N42 I115 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei D 2.84 BS02 FMN D 1 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei E 2.84 BS01 FMN E 1 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei E 2.84 BS02 FMN F 1 A38 S39 S40 N42 T111 I115 A38 S39 S40 N42 T111 I115 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei F 2.84 BS01 FMN E 1 A38 S39 S40 N42 T111 I115 A38 S39 S40 N42 T111 I115 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei F 2.84 BS02 FMN F 1 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei G 2.84 BS01 FMN G 1 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei G 2.84 BS02 FMN H 1 A38 S39 S40 N42 T111 I115 A38 S39 S40 N42 T111 I115 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei H 2.84 BS01 FMN G 1 A38 S39 S40 N42 I115 A38 S39 S40 N42 I115 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hei H 2.84 BS02 FMN H 1 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 H11 R12 S13 R15 Q67 W69 V132 P133 G135 G136 K172 R174 27005432 MNEAIRTIQDHRSIRQYTDEAVSDEHLDTIIQSAQSAASSINGQQVTIISVQDKEKKKKLSELAGNQAWIDQAPLFLIFCADFNRAKIAAELNDAPLGVTDGLESILVGATDAGISLEAATVAAESLGLGTVPIGGIRRKPLEVIELLDLPEYVFPVSGLVVGHPSDHSAKKPRLPQAAVHHRESYNHDLKSLIQDYDAEMAEYMKKRTNGADDRNWSQTVSAIYKTIYYPEVRAMLEKQGFKFEK 5hgc A 2.43 BS01 HCY A 1 V32 P33 A36 R246 T254 F256 K274 I277 Q278 S281 F380 N385 V12 P13 A16 R226 T234 F236 K254 I257 Q258 S261 F355 N360 SNAEAMAALKLVPNNADFAFQFFREVTQEAPNKNIFYSPVSISTAFAMLALGARSATQSQILEGLAFNLTEIQEKEIHEGFHNLIHMLNHPEGGVQLNMMNAIFVTAALALLRKFLDDAKALYQLEAFTTDFNKPTEAEKQINDYIERKTHGKITNLVKDMDPQTVMLLASFVYFKGSWEKPFEAEHTEEREFFVDAETTVKVPMMYQMGRFDFYFDEELSCTVVRLHYNGSATAFLVLPAKGKMKQLEQTLDKETIQKWSDHLFQRFMNLYFPKFSISGSYEISNTLRKMGIVDVFTNQADLSGITGSPDLKVSKVVHKASLDVDEKGTTAVEIMPISFPPTIEFSHPFLMLIFDRDTNSTLFIGKIVNPTI 5hgc A 2.43 BS02 BDG A 1 L71 K95 D138 L51 K75 D118 SNAEAMAALKLVPNNADFAFQFFREVTQEAPNKNIFYSPVSISTAFAMLALGARSATQSQILEGLAFNLTEIQEKEIHEGFHNLIHMLNHPEGGVQLNMMNAIFVTAALALLRKFLDDAKALYQLEAFTTDFNKPTEAEKQINDYIERKTHGKITNLVKDMDPQTVMLLASFVYFKGSWEKPFEAEHTEEREFFVDAETTVKVPMMYQMGRFDFYFDEELSCTVVRLHYNGSATAFLVLPAKGKMKQLEQTLDKETIQKWSDHLFQRFMNLYFPKFSISGSYEISNTLRKMGIVDVFTNQADLSGITGSPDLKVSKVVHKASLDVDEKGTTAVEIMPISFPPTIEFSHPFLMLIFDRDTNSTLFIGKIVNPTI 5hi0 A 2.60 BS01 CO A 1 H95 H97 E101 H140 H90 H92 E96 H135 4.1.1.2 27014926 DIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGTVSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEWAYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSFSNSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGPNGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHPNTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEIFKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKK 5hi0 A 2.60 BS02 CO A 2 H272 H274 E279 H318 E332 H267 H269 E274 H313 E327 4.1.1.2 27014926 DIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGTVSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEWAYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSFSNSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGPNGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHPNTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEIFKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKK 5hi0 A 2.60 BS03 OXL A 1 M84 R92 H95 H97 E101 L153 T164 M79 R87 H90 H92 E96 L148 T159 4.1.1.2 27014926 DIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGTVSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEWAYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSFSNSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGPNGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHPNTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEIFKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKK 5hi2 A 2.51 BS01 BAX A 1 V471 A481 K483 E501 V504 L505 I513 L514 T529 Q530 W531 C532 L567 I572 H574 F583 I592 G593 D594 F595 V23 A33 K35 E48 V51 L52 I60 L61 T76 Q77 W78 C79 L114 I119 H121 F130 I139 G140 D141 F142 2.7.11.1 26996308 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLSILWMAPEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 5hib A 2.85 BS01 63M A 1 L718 G719 F723 V726 A743 K745 C775 M790 Q791 L792 M793 R841 N842 L844 T854 D855 L23 G24 F28 V31 A48 K50 C80 M95 Q96 L97 M98 R146 N147 L149 T159 D160 2.7.10.1 26996308 GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALDMDDVVDADEYLI 5hic A 2.60 BS01 63N A 1 L718 F723 V726 A743 K745 M766 C775 M790 Q791 M793 N842 L844 T854 D855 L22 F27 V30 A47 K49 M68 C77 M92 Q93 M95 N144 L146 T156 D157 2.7.10.1 26996308 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYEEDMDDVVDADEYLIP 5hid A 2.50 BS01 B1E A 1 I463 V471 A481 K483 E501 V504 L505 L514 I527 T529 Q530 W531 C532 H574 F583 I592 G593 D594 F595 I15 V23 A33 K35 E48 V51 L52 L61 I74 T76 Q77 W78 C79 H121 F130 I139 G140 D141 F142 2.7.11.1 26996308 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLAEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELS 5hid B 2.50 BS01 B1E B 1 I463 V471 A481 V482 K483 E501 V504 L505 L514 I527 T529 Q530 W531 C532 H574 F583 I592 G593 D594 F595 I15 V23 A33 V34 K35 E48 V51 L52 L61 I74 T76 Q77 W78 C79 H121 F130 I139 G140 D141 F142 2.7.11.1 26996308 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELS 5hie A 3.00 BS01 P06 A 1 I463 G464 G466 F468 V471 A481 K483 L505 L514 F516 I527 T529 Q530 W531 C532 F583 G593 D594 F595 I15 G16 G18 F20 V23 A33 K35 L52 L61 F63 I74 T76 Q77 W78 C79 F130 G140 D141 F142 2.7.11.1 26996308 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP 5hie B 3.00 BS01 P06 B 1 I463 G464 S465 G466 F468 V471 A481 K483 F498 L505 L514 F516 I527 T529 Q530 W531 C532 F583 G593 D594 F595 I15 G16 S17 G18 F20 V23 A33 K35 F45 L52 L61 F63 I74 T76 Q77 W78 C79 F130 G140 D141 F142 2.7.11.1 26996308 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP 5hie C 3.00 BS01 P06 C 1 I463 G464 S465 G466 F468 V471 A481 K483 V504 L514 F516 I527 T529 Q530 W531 C532 F583 G593 D594 F595 I15 G16 S17 G18 F20 V23 A33 K35 V51 L61 F63 I74 T76 Q77 W78 C79 F130 G140 D141 F142 2.7.11.1 26996308 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP 5hie D 3.00 BS01 P06 D 1 I463 G464 S465 G466 F468 V471 A481 K483 V504 L514 F516 I527 T529 Q530 W531 C532 N580 F583 G593 D594 F595 I15 G16 S17 G18 F20 V23 A33 K35 V51 L61 F63 I74 T76 Q77 W78 C79 N127 F130 G140 D141 F142 2.7.11.1 26996308 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP 5hjp B 2.60 BS01 668 B 1 N239 S242 F268 F271 T272 L274 A275 I277 S278 E281 I309 M312 T316 R319 F329 L330 L345 F349 H435 Q438 L442 L449 L453 W457 N23 S26 F50 F53 T54 L56 A57 I59 S60 E63 I91 M94 T98 R101 F111 L112 L127 F131 H217 Q220 L224 L231 L235 W239 27011007 GVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPADPASGSASQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHEGSGSGSHKILHRLLQD 5hjp D 2.60 BS01 668 D 1 N239 F268 T272 L274 A275 I277 S278 E281 I309 M312 T316 R319 F329 L330 L345 F349 H435 Q438 L442 L449 L453 W457 N21 F42 T46 L48 A49 I51 S52 E55 I83 M86 T90 R93 F103 L104 L119 F123 H209 Q212 L216 L223 L227 W231 27011007 QLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPSASQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHEGSGSGSHKILHRLLQD 5hjs A 1.72 BS01 III C 1 V105 K109 R119 E120 I123 A124 L126 K127 N207 P273 L274 E277 V49 K53 R63 E64 I67 A68 L70 K71 N151 P217 L218 E221 27011007 QLSPEQLGMIEKLVAAQQLRVTPWPSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 5hjs A 1.72 BS02 668 A 1 F93 T94 L96 A97 E103 I131 M134 T138 R141 F151 L152 L167 F171 H257 Q260 L264 L271 W279 F37 T38 L40 A41 E47 I75 M78 T82 R85 F95 L96 L111 F115 H201 Q204 L208 L215 W223 27011007 QLSPEQLGMIEKLVAAQQLRVTPWPSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 5hjs B 1.72 BS01 III D 1 V105 K109 F114 R119 E120 I123 A124 L126 K127 N207 P273 L274 E277 I278 V49 K53 F58 R63 E64 I67 A68 L70 K71 N151 P217 L218 E221 I222 27011007 QLSPEQLGMIEKLVAAQQLRVTPWPSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 5hjs B 1.72 BS02 668 B 1 F90 F93 T94 L96 S100 E103 I131 M134 T138 R141 F151 L152 L167 F171 H257 Q260 L264 L271 W279 F34 F37 T38 L40 S44 E47 I75 M78 T82 R85 F95 L96 L111 F115 H201 Q204 L208 L215 W223 27011007 QLSPEQLGMIEKLVAAQQLRVTPWPSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 5hk1 A 2.51 BS01 61W A 1 W89 M93 L105 F107 Y120 I124 D126 H154 E172 T181 L182 Y206 W82 M86 L98 F100 Y113 I117 D119 H147 E165 T174 L175 Y199 RWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLF 5hk1 B 2.51 BS01 61W B 1 W89 M93 L105 F107 Y120 I124 D126 H154 E172 I178 L182 Y206 W89 M93 L105 F107 Y120 I124 D126 H154 E172 I178 L182 Y206 MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLF 5hk1 C 2.51 BS01 61W C 1 W89 L105 F107 S117 Y120 D126 H154 W164 E172 I178 T181 L182 Y206 W88 L104 F106 S116 Y119 D125 H153 W163 E171 I177 T180 L181 Y205 QWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFG 5hk2 A 3.20 BS01 61V A 1 V84 M93 L105 F107 S117 Y120 D126 H154 E172 I178 Y206 V83 M92 L104 F106 S116 Y119 D125 H153 E171 I177 Y205 QWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYL 5hk2 B 3.20 BS01 61V B 1 V78 W83 M87 L99 F101 Y114 D120 E166 I172 L176 A179 Y200 V76 W81 M85 L97 F99 Y112 D118 E164 I170 L174 A177 Y198 WAVGRLLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFG 5hk2 C 3.20 BS01 61V C 1 V84 W89 M93 F107 S117 Y120 I124 D126 H154 W164 E172 I178 T181 L182 A185 Y206 V77 W82 M86 F100 S110 Y113 I117 D119 H147 W157 E165 I171 T174 L175 A178 Y199 RWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLF 5hmh A 1.79 BS01 62R A 1 Q24 L54 L57 G58 I61 M62 Y67 Q72 F91 V93 H96 I99 Y100 Q6 L36 L39 G40 I43 M44 Y49 Q54 F73 V75 H78 I81 Y82 6.3.2.- 26985323 ASASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQ 5hmh A 1.79 BS02 62R B 1 K51 L54 Y55 K33 L36 Y37 6.3.2.- 26985323 ASASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQ 5hmh B 1.79 BS01 62R A 1 K51 L54 Y55 K31 L34 Y35 6.3.2.- 26985323 ASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSAGA 5hmh B 1.79 BS02 62R B 1 Q24 K51 L54 L57 G58 I61 M62 Y67 Q72 F91 V93 H96 I99 Y100 Q4 K31 L34 L37 G38 I41 M42 Y47 Q52 F71 V73 H76 I79 Y80 6.3.2.- 26985323 ASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSAGA 5hmi A 1.74 BS01 62T A 1 Q24 L54 L57 G58 I61 M62 Y67 Q72 F91 V93 H96 I99 Y100 Q7 L37 L40 G41 I44 M45 Y50 Q55 F74 V76 H79 I82 Y83 6.3.2.- 26985323 QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQ 5hmi A 1.74 BS02 62T B 1 K51 L54 K34 L37 6.3.2.- 26985323 QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQ 5hmi B 1.74 BS01 62T A 1 K51 L54 Y55 K32 L35 Y36 6.3.2.- 26985323 PASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSAGA 5hmi B 1.74 BS02 62T B 1 L54 L57 G58 I61 M62 Y67 Q72 F91 V93 H96 I99 Y100 L35 L38 G39 I42 M43 Y48 Q53 F72 V74 H77 I80 Y81 6.3.2.- 26985323 PASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSAGA 5hmk A 2.17 BS01 62Q A 1 L54 L57 G58 I61 M62 Y67 Q72 F91 V93 H96 I99 Y100 L29 L32 G33 I36 M37 Y42 Q47 F66 V68 H71 I74 Y75 6.3.2.- 26985323 TLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN 5hmk A 2.17 BS02 62Q B 1 K51 E52 Y55 K26 E27 Y30 6.3.2.- 26985323 TLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN 5hmk B 2.17 BS01 62Q A 1 K51 L54 K31 L34 6.3.2.- 26985323 ASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN 5hmk B 2.17 BS02 62Q B 1 Q24 L54 L57 G58 I61 M62 Y67 Q72 F91 V93 H96 I99 Y100 Q4 L34 L37 G38 I41 M42 Y47 Q52 F71 V73 H76 I79 Y80 6.3.2.- 26985323 ASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN 5hrt A 2.00 BS01 NUC B 1 H242 R244 G245 R246 E247 F312 H315 K316 F371 P386 H452 A454 R455 K456 P457 L458 S465 K467 F469 F470 D473 H186 R188 G189 R190 E191 F256 H259 K260 F315 P330 H396 A398 R399 K400 P401 L402 S409 K411 F413 F414 D417 3.1.4.39 TNTSGSCKGRCFELQDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTLPEEVSRPNYPGIMYLQSDFDLGCTCDSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLVKKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI 5hrt A 2.00 BS02 ZN A 1 D171 T209 D358 H359 D115 T153 D302 H303 3.1.4.39 TNTSGSCKGRCFELQDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTLPEEVSRPNYPGIMYLQSDFDLGCTCDSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLVKKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI 5hrt A 2.00 BS03 ZN A 2 D311 H315 H474 D255 H259 H418 3.1.4.39 TNTSGSCKGRCFELQDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTLPEEVSRPNYPGIMYLQSDFDLGCTCDSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLVKKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI 5hrt A 2.00 BS04 CA A 1 D735 N737 N739 L741 R742 D743 D663 N665 N667 L669 R670 D671 3.1.4.39 TNTSGSCKGRCFELQDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTLPEEVSRPNYPGIMYLQSDFDLGCTCDSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLVKKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI 5hw0 A 1.70 BS01 GLU A 1 G14 T15 A61 S62 E63 G94 T95 D96 G12 T13 A45 S46 E47 G78 T79 D80 3.5.1.1 26855287 KLPNIVILATGGTIAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5hw0 B 1.70 BS01 GLU B 1 G14 T15 A61 S62 E63 G94 T95 D96 A120 G12 T13 A42 S43 E44 G75 T76 D77 A101 3.5.1.1 26855287 KLPNIVILATGGTIAGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5hw0 C 1.70 BS01 GLU C 1 G14 T15 A61 S62 E63 G94 T95 D96 A120 G12 T13 A45 S46 E47 G78 T79 D80 A104 3.5.1.1 26855287 KLPNIVILATGGTIAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5hw0 D 1.70 BS01 GLU D 1 G14 T15 A61 S62 E63 G94 T95 D96 A120 G12 T13 A59 S60 E61 G92 T93 D94 A118 3.5.1.1 26855287 KLPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5hzn A 2.20 BS01 66A A 1 L1002 G1003 Q1004 G1005 F1007 V1010 A1028 K1030 F1044 E1047 M1051 V1060 M1076 E1077 M1079 M1139 G1149 D1150 L23 G24 Q25 G26 F28 V31 A49 K51 F65 E68 M72 V81 M97 E98 M100 M152 G162 D163 2.7.10.1 26951750 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn B 2.20 BS01 66A B 1 L1002 G1003 Q1004 F1007 V1010 A1028 K1030 F1044 E1047 V1060 M1076 E1077 M1079 D1083 R1136 M1139 G1149 D1150 L23 G24 Q25 F28 V31 A49 K51 F65 E68 V81 M97 E98 M100 D104 R149 M152 G162 D163 2.7.10.1 26951750 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn C 2.20 BS01 66A C 1 L1002 G1003 Q1004 F1007 V1010 A1028 K1030 F1044 E1047 M1051 V1060 M1076 E1077 M1079 D1083 R1136 M1139 G1149 D1150 L23 G24 Q25 F28 V31 A49 K51 F65 E68 M72 V81 M97 E98 M100 D104 R149 M152 G162 D163 2.7.10.1 26951750 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn D 2.20 BS01 66A D 1 L1002 G1003 Q1004 G1005 V1010 A1028 K1030 F1044 E1047 A1048 M1051 V1060 M1076 E1077 M1079 D1083 M1139 G1149 D1150 L23 G24 Q25 G26 V31 A49 K51 F65 E68 A69 M72 V81 M97 E98 M100 D104 M160 G170 D171 2.7.10.1 26951750 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAMANNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn E 2.20 BS01 66A E 1 L1002 G1003 Q1004 G1005 F1007 V1010 A1028 K1030 F1044 E1047 M1051 V1060 M1076 E1077 M1079 M1139 G1149 D1150 L23 G24 Q25 G26 F28 V31 A49 K51 F65 E68 M72 V81 M97 E98 M100 M152 G162 D163 2.7.10.1 26951750 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn F 2.20 BS01 66A F 1 L1002 G1003 Q1004 F1007 V1010 A1028 K1030 F1044 E1047 V1060 M1076 E1077 M1079 D1083 R1136 M1139 G1149 D1150 L23 G24 Q25 F28 V31 A49 K51 F65 E68 V81 M97 E98 M100 D104 R149 M152 G162 D163 2.7.10.1 26951750 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn G 2.20 BS01 66A G 1 L1002 G1003 Q1004 F1007 V1010 A1028 K1030 F1044 E1047 M1051 V1060 M1076 E1077 M1079 D1083 R1136 M1139 G1149 D1150 L23 G24 Q25 F28 V31 A49 K51 F65 E68 M72 V81 M97 E98 M100 D104 R149 M152 G162 D163 2.7.10.1 26951750 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn H 2.20 BS01 66A H 1 L1002 G1003 Q1004 G1005 V1010 A1028 K1030 F1044 E1047 A1048 M1051 V1060 M1076 E1077 M1079 D1083 M1139 G1149 D1150 L23 G24 Q25 G26 V31 A49 K51 F65 E68 A69 M72 V81 M97 E98 M100 D104 M160 G170 D171 2.7.10.1 26951750 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAMANNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN 5i25 A 2.85 BS01 III B 1 K103 N106 Y107 N108 S109 T132 A134 H143 I146 L148 L163 K103 N106 Y107 N108 S109 T132 A134 H143 I146 L148 L163 3.4.21.27 27006387 ECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYCKGDSGGPLSCKHNEVWHLVGITSWGEGCAERPGVYTNVVEYVDWILEKTQ 5i67 A 2.60 BS01 GDP A 1 S271 A272 G274 K275 T276 N277 W500 F501 F509 G513 F514 N517 S264 A265 G267 K268 T269 N270 W483 F484 F492 G496 F497 N500 4.1.1.32 GLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEEFQRLCDQLVEAGTFIRLNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNWMDPGEMRSIMKDLYRGCMRGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMTRMGKAALEKMGDDGFFVKALHSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSASGKTNLAMLQPTIPGWRAETLGDDIAWMRFGKDGLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGNTVFTNVALTDDGDVWWEGLEGDPQHLIDWKGNDWYFRETETNAAHPNSRYCTPMSQCPILAPEWDDPQGVPISGILFGGRRKTTVPLVTEARDWQHGVFIGATLGSENVRRDPMAMLPFLGYNVGDYFQHWINLGKHADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWIVDRIEHKAGGATTPIGTVPAVEDLDLDGLDVDAADVAAALAVDADEWRQELPLIEEWLQFVGEKLPTGVKDEFDALKERLG 5i67 A 2.60 BS02 MN A 1 K229 H249 S271 K275 D296 K222 H242 S264 K268 D289 4.1.1.32 GLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEEFQRLCDQLVEAGTFIRLNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNWMDPGEMRSIMKDLYRGCMRGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMTRMGKAALEKMGDDGFFVKALHSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSASGKTNLAMLQPTIPGWRAETLGDDIAWMRFGKDGLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGNTVFTNVALTDDGDVWWEGLEGDPQHLIDWKGNDWYFRETETNAAHPNSRYCTPMSQCPILAPEWDDPQGVPISGILFGGRRKTTVPLVTEARDWQHGVFIGATLGSENVRRDPMAMLPFLGYNVGDYFQHWINLGKHADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWIVDRIEHKAGGATTPIGTVPAVEDLDLDGLDVDAADVAAALAVDADEWRQELPLIEEWLQFVGEKLPTGVKDEFDALKERLG 5ibd A 1.77 BS01 HEM A 1 M62 M86 H146 F230 G234 S237 T238 F241 F280 L284 R286 A337 F338 G339 H343 C345 P346 G347 M60 M84 H144 F228 G232 S235 T236 F239 F278 L282 R284 A335 F336 G337 H341 C343 P344 G345 1.14.21.9 27002486 ATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibd A 1.77 BS02 GGJ A 1 T77 V78 V82 V83 A167 F168 V228 A233 S237 F280 R386 T75 V76 V80 V81 A165 F166 V226 A231 S235 F278 R384 1.14.21.9 27002486 ATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibe A 1.62 BS01 HEM A 1 M62 M86 H146 F230 G234 S237 T238 F241 F280 L284 R286 A337 F338 G339 H343 C345 P346 G347 M60 M84 H144 F228 G232 S235 T236 F239 F278 L282 R284 A335 F336 G337 H341 C343 P344 G345 1.14.21.9 27002486 ATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibe A 1.62 BS02 69M A 1 T77 V78 V82 V83 A167 F168 T229 A233 S237 F280 R386 T75 V76 V80 V81 A165 F166 T227 A231 S235 F278 R384 1.14.21.9 27002486 ATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibf A 1.70 BS01 HEM A 1 M62 M86 H146 F230 G234 S237 T238 F241 F280 L284 R286 A337 F338 G339 H343 C345 P346 G347 M59 M83 H143 F227 G231 S234 T235 F238 F277 L281 R283 A334 F335 G336 H340 C342 P343 G344 1.14.21.9 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibf A 1.70 BS02 69W A 1 V78 V82 V83 A233 S237 F280 R386 V75 V79 V80 A230 S234 F277 R383 1.14.21.9 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibf A 1.70 BS03 69W A 2 T77 V78 A167 F168 A178 W182 T229 Q385 T74 V75 A164 F165 A175 W179 T226 Q382 1.14.21.9 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibg A 2.10 BS01 HEM A 1 M62 M86 H146 F230 G234 S237 T238 F241 F280 L284 R286 A337 F338 G339 H343 C345 P346 G347 M56 M80 H140 F224 G228 S231 T232 F235 F274 L278 R280 A331 F332 G333 H337 C339 P340 G341 1.14.-.- 27002486 LEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibg A 2.10 BS02 69S A 1 T77 V78 A167 F168 W182 V228 T229 G232 A233 S237 F280 Q385 R386 T71 V72 A161 F162 W176 V222 T223 G226 A227 S231 F274 Q379 R380 1.14.-.- 27002486 LEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibg A 2.10 BS03 69S A 2 T77 V78 P79 K179 W182 D183 T71 V72 P73 K173 W176 D177 1.14.-.- 27002486 LEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibh A 2.02 BS01 HEM A 1 M62 M86 H146 F230 A233 G234 S237 T238 F241 F280 L284 R286 L309 A337 F338 G339 H343 C345 P346 G347 M59 M83 H143 F227 A230 G231 S234 T235 F238 F277 L281 R283 L306 A334 F335 G336 H340 C342 P343 G344 1.14.-.- 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibh A 2.02 BS02 69R A 1 E64 A67 A68 G69 A70 P71 L287 T289 K301 G302 E61 A64 A65 G66 A67 P68 L284 T286 K298 G299 1.14.-.- 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibh A 2.02 BS03 69R A 2 N74 A75 L76 T77 V78 V82 N85 A167 F168 W182 V228 Q385 N71 A72 L73 T74 V75 V79 N82 A164 F165 W179 V225 Q382 1.14.-.- 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibi A 2.20 BS01 69U A 1 R72 L76 T77 V78 V82 V83 N85 A167 F168 W182 V228 Q385 R69 L73 T74 V75 V79 V80 N82 A164 F165 W179 V225 Q382 1.14.-.- 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibi A 2.20 BS02 HEM A 1 M62 M86 H146 A233 G234 S237 T238 F241 F280 L284 R286 A337 F338 G339 H343 C345 P346 G347 M59 M83 H143 A230 G231 S234 T235 F238 F277 L281 R283 A334 F335 G336 H340 C342 P343 G344 1.14.-.- 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibj A 2.50 BS01 HEM A 1 M62 M86 H146 F230 A233 G234 S237 T238 F241 F280 L284 R286 A337 F338 G339 H343 C345 P346 L350 M59 M83 H143 F227 A230 G231 S234 T235 F238 F277 L281 R283 A334 F335 G336 H340 C342 P343 L347 1.14.-.- 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5ibj A 2.50 BS02 69T A 1 V78 S163 L164 A167 F168 W182 D185 V228 T229 V75 S160 L161 A164 F165 W179 D182 V225 T226 1.14.-.- 27002486 TVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 5icr A 2.25 BS01 649 A 1 L215 G223 H231 D232 M233 T237 L240 A241 I278 L311 S314 E315 P316 I317 S342 Y343 G344 L345 A346 L350 D469 I480 R483 K601 L206 G214 H222 D223 M224 T228 L231 A232 I269 L302 S305 E306 P307 I308 S333 Y334 G335 L336 A337 L341 D460 I471 R474 K578 FIKDGQIKFPDGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVIAVDAVPDDVASTWVNPDEPDETTIAYLQYTSRIPTGVQITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVRTGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKAIRTGYVAAFSVPANQLPDEDPDDTSEQLVIVAERAPKLDIGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLDGSLRAGKVANDFPDATD 5icr B 2.25 BS01 649 B 1 T187 L215 G223 H231 D232 M233 T237 L240 A241 I278 V280 L311 S314 E315 P316 S342 Y343 G344 L345 A346 L350 D469 I480 R483 K601 T180 L205 G213 H221 D222 M223 T227 L230 A231 I268 V270 L301 S304 E305 P306 S332 Y333 G334 L335 A336 L340 D459 I470 R473 K581 IKDGQIKFPDGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVIAVDAVPDDVASTWVNPDEPDETTIAYLQYTSRIPTGVQITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVRTGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKAIRTGYVAAFSVPANQLPDEVFKRDPDDTSEQLVIVAERAPKLDIGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLDGSLRAGKVANDFPDAT 5icr C 2.25 BS01 649 C 1 L215 G223 H231 D232 M233 T237 L240 I278 V280 L311 S314 E315 P316 I317 S342 Y343 G344 L345 A346 L350 D469 I480 R483 K601 L205 G213 H221 D222 M223 T227 L230 I268 V270 L301 S304 E305 P306 I307 S332 Y333 G334 L335 A336 L340 D459 I470 R473 K589 FIKDQIKFPDGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVIAVDAVPDDVASTWVNPDEPDETTIAYLQYTSRIPTGVQITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVRTGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKAIRTGYVAAFSVPANQLPDEVFENAHSGIKRDPDDTSEQLVIVAERAPGKLDIGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLDGSLRAGKVANDFPDATD 5icr D 2.25 BS01 649 D 1 L215 G223 H231 D232 M233 T237 L240 A241 I278 V280 L311 S314 E315 P316 I317 S342 Y343 G344 L345 A346 L350 D469 I480 R483 K601 L205 G213 H221 D222 M223 T227 L230 A231 I268 V270 L301 S304 E305 P306 I307 S332 Y333 G334 L335 A336 L340 D459 I470 R473 K581 FIKDGQIKFPSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVIAVDAVPDDVASTWVNPDEPDETTIAYLQYTSTRIPTGVQITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVRTGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKAIRTGYVAAFSVPANQLPDEVDPDDTSEQLVIVAERAPGAHKLDIGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLDGSLRAGKVANDFPDAT 5icu A 1.46 BS01 CU A 1 H23 D105 H107 H1 D83 H85 27010565 HSFLVDASPSAKDHVAASPKLVKLRFGGGVEPAYSSISILDSTGKLVVEGAKGQADKPRELTLDAPELAVGSYVVKFRVLSSDGHIVEGKYEFTVDPHENLY 5ihx A 2.30 BS01 TYR A 1 Y127 G129 D131 L161 D171 Y275 Q279 D282 Q294 Q300 Y55 G57 D59 L89 D99 Y203 Q207 D210 Q222 Q228 6.1.1.1 IEEGKKEWAQFAQEIKEGKRKSFVEHLEERGLIHDVVGDRDLLHRVFTEKRVGIYAGVDPTAPSMHVGHMLPFMVLAWGYVWGLPVTFLLGGATSRVGDPTGRLKGREQVHSSVRKANMASMHMQLKKLGASIERYGEKHGYKRQMIWRRTLTNNNVWWNKTPLLEVLRDLGAYIRIGPMLGRDTVKNRMERGDGMSFAEFTYPLMQAWDWWMLFKNGCQVQVGGSDQYGNILFGVGAVKTISKNTVLQEDNNPLSDDLDKPIGFTTPLLTTSNAIWLDKDMTSTFELYQFFVRTPDDAVERYLKMFTFLPIPEISKIMEEQNQDPSRRVAQHALAYEFVELIHGKDEADAVSMQHRQLF 5iis A 2.10 BS01 6CB A 1 L44 G45 F49 V52 A65 K67 I104 L120 E121 R122 V126 D128 E171 L174 I185 D186 L13 G14 F18 V21 A34 K36 I73 L89 E90 R91 V95 D97 E140 L143 I154 D155 2.7.11.1 26995528 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 5ijx A 2.63 BS01 TYR A 1 Y114 G116 V117 D118 L148 T153 D158 Y262 Q266 D269 Q281 Q287 Y65 G67 V68 D69 L99 T104 D109 Y207 Q211 D214 Q226 Q232 6.1.1.1 RHITQQHLRRTAEAEEQWKLQAKEIEAGRKQSFLSFLEERGLVNSVVGQRDALDKLITRKRVGFYAGVDPTAPSLHIGHMLPFMILGWAYVHGLKAVFLIGGSTAKIGDPTGRMDGATRRANIANIHLQLKRLGFSFEKYGRKHGFEWEWAWRRALENNNTWWNKQSLKEVMEVLGTSLRLGPMLGRDYVKSRLASGEGMSIAEFCYPIMQGWDFWYLFQRKVQVQVGGSDQYGNILFGMDAIKGILKANPESEWAPKKDEDPDLANPYGITTPLLTTASGEKAVWLDKDMTSCYDLYQYFVRVADSDVERYLKMFTFVPTPAIKELMEEHAKDPSKRVAQHKLAREFVELIHGSLSAEQAAKDH 5ivn A 1.00 BS01 III B 1 F37 Q39 E44 R45 E46 G47 S49 C50 Y59 Y60 A61 C102 K103 R104 G105 R106 Y107 E108 Y109 D110 F111 F36 Q38 E43 R44 E45 G46 S48 C49 Y58 Y59 A60 C101 K102 R103 G104 R105 Y106 E107 Y108 D109 F110 26791954 VQLVESGGGLVQPGGSLTLSCTASGFTLDHYDIGWFRQAPGKEREGVSCINNSDDDTYYADSVKGRFTIFMNNAKDTVYLQMNSLKPEDTAIYYCAEARGCKRGRYEYDFWGQGTQVTVSS 5j1z A 1.73 BS01 CA A 1 D21 R35 D40 T41 E43 D15 R29 D34 T35 E37 3.1.31.1 LHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPEFNEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLDYIYADGKMVNEALVRQGLAKVAYVYKGNNTHEQLLRKAEAQAKKEKLNIWS 5j1z A 1.73 BS02 THP A 1 R35 D40 K84 Y85 R87 L89 Y113 Y115 R29 D34 K72 Y73 R75 L77 Y101 Y103 3.1.31.1 LHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPEFNEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLDYIYADGKMVNEALVRQGLAKVAYVYKGNNTHEQLLRKAEAQAKKEKLNIWS 5j22 A 1.90 BS01 CA A 1 D21 R35 D40 T41 E43 D15 R29 D34 T35 E37 3.1.31.1 LHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPEFNEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEADVRQGLAKVAYVYKGNNTHEQLLRKAEAQAKKEKLNIWS 5j22 A 1.90 BS02 THP A 1 R35 D40 K84 Y85 R87 L89 Y113 Y115 R29 D34 K72 Y73 R75 L77 Y101 Y103 3.1.31.1 LHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPEFNEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEADVRQGLAKVAYVYKGNNTHEQLLRKAEAQAKKEKLNIWS