2n3k A BS01 III B 1 Y612 K615 R616 S619 L620 I622 N623 G627 L630 V634 D650 E651 I652 E653 I654 D655 F656 E657 Y13 K16 R17 S20 L21 I23 N24 G28 L31 V35 D51 E52 I53 E54 I55 D56 F57 E58 26858406 ESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKK 3x3e A 2.39 BS01 LYS A 1 E124 E125 A126 S129 R162 R236 T300 E119 E120 A121 S124 R157 R225 T289 3.5.1.- LDPVEFLKGALEIPSPSGKERLVAEYLAEGMQKLGLKGFVDEADNARGQVGEGPVQVVLLGHIDTVPGQIPVRLEGGRLFGRGAVDAKGPFVAMIFAAAGLSEEARKRLTVHLVGATEEEAPSSKGARFVAPRLKPHYAVIGEPSGWEGITLGYKGRLLVKARREKDHEPNAAEELISYFVAIKAWAEAMNVGQRPFDQVQYTLRDFRVHPAELRQVAEMFFDLRLPPRLPPEEAIRHLTAYAPPTIELEFFGREVPYQGPKDTPLTRAFRQAIRKAGGRPVFKLKTGTSDMNVLAPHWPVPMVAYGPGDSTLDHTPYEHVEVAEFLKGIEVLRGALEALAQTHAG 4xmt A 2.00 BS02 DPP A 1 E121 A262 M263 E264 H297 E298 H301 E320 Y381 E118 A259 M260 E261 H294 E295 H298 E317 Y378 3.4.11.2 QPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNAGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xmu A 2.91 BS02 ALA A 1 E121 A262 E264 H297 E298 K319 E320 Y381 E117 A258 E260 H293 E294 K315 E316 Y377 3.4.11.2 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNAGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xn1 A 2.20 BS02 GLU A 1 A260 A262 E264 H297 E298 H301 E320 Y376 Y381 A257 A259 E261 H294 E295 H298 E317 Y373 Y378 3.4.11.2 QPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNAGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xn2 A 2.11 BS02 LEU A 1 Q119 E121 A260 A262 M263 E264 H297 E298 E320 Y376 Y381 Q115 E117 A256 A258 M259 E260 H293 E294 E316 Y372 Y377 3.4.11.2 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNAGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xn4 A 1.99 BS02 MET A 1 Q119 E121 A260 A262 M263 E264 H297 E298 H301 K319 E320 Y376 Y381 Q115 E117 A256 A258 M259 E260 H293 E294 H297 K315 E316 Y372 Y377 3.4.11.2 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNAGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xn4 A 1.99 BS04 MET A 3 R728 D729 M732 Q753 S756 R724 D725 M728 Q749 S752 3.4.11.2 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNAGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xn4 A 1.99 BS05 MET A 4 D281 F704 H705 A707 M710 A713 K738 W739 D277 F700 H701 A703 M706 A709 K734 W735 3.4.11.2 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNAGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xn7 A 2.22 BS02 DPP A 1 E121 A262 M263 E264 H297 E298 H301 K319 E320 Y381 E117 A258 M259 E260 H293 E294 H297 K315 E316 Y377 3.4.11.2 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xna A 2.40 BS02 B3K A 1 E121 M260 A262 M263 E264 H297 E298 K319 E320 N373 Y376 Y381 E117 M256 A258 M259 E260 H293 E294 K315 E316 N369 Y372 Y377 3.4.11.2 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xnd A 1.93 BS02 HT7 A 1 Q119 E121 M260 A262 M263 E264 H297 E298 H301 K319 E320 N373 Y376 Y381 Q115 E117 M256 A258 M259 E260 H293 E294 H297 K315 E316 N369 Y372 Y377 3.4.11.2 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4xtc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xtc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xtc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xtc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xtc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y35 A 1.46 BS01 F90 A 1 D35 G37 S38 Y79 F194 D219 I300 I302 I304 D35 G37 S38 Y79 F194 D219 I300 I302 I304 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y38 A 1.10 BS01 0A9 A 1 D33 D35 Y79 G80 D81 S83 D219 G221 T222 D33 D35 Y79 G80 D81 S83 D219 G221 T222 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y4a A 1.28 BS01 47G A 1 D33 D35 Y79 D81 S83 S115 F116 D119 I122 L125 G221 D33 D35 Y79 D81 S83 S115 F116 D119 I122 L125 G221 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y4t A 1.30 BS01 46X A 1 D35 Y79 G80 D81 F116 L125 D219 G221 T222 D35 Y79 G80 D81 F116 L125 D219 G221 T222 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y4t A 1.30 BS02 46X A 2 S233 W236 A237 A242 K243 S244 Y251 S233 W236 A237 A242 K243 S244 Y251 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y4u A 1.75 BS01 46V A 1 D15 A16 D81 T222 T223 D15 A16 D81 T222 T223 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y4w A 1.45 BS02 46W A 2 D33 Y79 G80 D81 S83 F116 G221 T222 D33 Y79 G80 D81 S83 F116 G221 T222 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y4x A 1.67 BS01 47Q A 1 D15 A16 D81 S115 F116 D119 G221 T222 T223 D15 A16 D81 S115 F116 D119 G221 T222 T223 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y4z A 1.48 BS01 47R A 1 D33 D81 S83 S115 F116 I122 D33 D81 S83 S115 F116 I122 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y50 A 1.32 BS01 47S A 1 D35 G37 S78 Y79 G80 I217 D219 D35 G37 S78 Y79 G80 I217 D219 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y53 A 1.62 BS01 47B A 1 D15 D119 I122 T223 L224 Y226 F291 D15 D119 I122 T223 L224 Y226 F291 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y53 A 1.62 BS02 47B A 2 G80 F194 I217 D219 T222 Y226 I300 I304 G80 F194 I217 D219 T222 Y226 I300 I304 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y54 A 1.61 BS01 47E A 1 G241 V252 F253 P254 S288 S289 G241 V252 F253 P254 S288 S289 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y56 A 1.63 BS01 47J A 1 D33 D35 Y79 D81 S83 I122 L125 G221 D33 D35 Y79 D81 S83 I122 L125 G221 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y57 A 1.49 BS01 F63 A 1 D33 D35 Y79 D81 S83 S115 F116 L125 G221 T222 D33 D35 Y79 D81 S83 S115 F116 L125 G221 T222 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y58 A 1.17 BS01 47L A 1 D35 G37 Y79 G80 L125 F194 I217 D219 G221 T222 I304 D35 G37 Y79 G80 L125 F194 I217 D219 G221 T222 I304 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5b A 1.24 BS01 47P A 1 D33 Y79 D81 S115 F116 D119 D33 Y79 D81 S115 F116 D119 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5b A 1.24 BS02 47P A 2 I10 D15 T223 I10 D15 T223 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5b A 1.24 BS03 47P A 3 G80 F194 I217 D219 I300 G301 I304 G80 F194 I217 D219 I300 G301 I304 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5c A 1.19 BS01 47V A 1 D35 Y79 D81 S115 F116 L125 G221 D35 Y79 D81 S115 F116 L125 G221 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5e A 1.12 BS01 47T A 1 G37 S38 I77 Y79 G80 L133 F194 I304 G37 S38 I77 Y79 G80 L133 F194 I304 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5g A 1.47 BS01 47U A 1 D35 Y79 G80 D81 L125 G221 T222 Y226 I300 I304 D35 Y79 G80 D81 L125 G221 T222 Y226 I300 I304 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5k A 1.44 BS01 489 A 1 D35 G37 Y79 G80 F194 I217 D219 I302 I304 D35 G37 Y79 G80 F194 I217 D219 I302 I304 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5m A 1.28 BS01 47Y A 1 I10 D15 Y79 D81 S83 F116 D119 T223 I10 D15 Y79 D81 S83 F116 D119 T223 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5m A 1.28 BS02 47Y A 2 D15 L224 F291 D15 L224 F291 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5n A 1.29 BS01 487 A 1 D15 V248 F280 G281 P282 F291 D15 V248 F280 G281 P282 F291 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y5p A 1.23 BS01 483 A 1 D35 Y79 G80 D81 G221 Y226 I300 D35 Y79 G80 D81 G221 Y226 I300 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4y60 C 1.75 BS01 NUC A 1 R5 N8 F10 R18 A31 S34 K35 G38 W41 K42 Y72 R73 R6 N9 F11 R19 A32 S35 K36 G39 W42 K43 Y73 R74 GLRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRVQHLRDHPNYKYRPR 4y60 C 1.75 BS02 NUC B 1 R2 R4 R5 M7 N8 M11 K15 R18 N30 Y72 P74 R75 R3 R5 R6 M8 N9 M12 K16 R19 N31 Y73 P75 R76 GLRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRVQHLRDHPNYKYRPR 4y8e A 1.61 BS01 CA A 1 N98 I99 E135 N96 I97 E133 RVASPSSELRRALEANEFIPYYQPLSPGQGGRWIGVEVLMRWRHPREGLIRPDLFIPFAERSGLIVPMTRALMRQVAEDLGGHAGKLEPGFHIGFNISATHCHELALVDDCRELLAAFPPGHITLVLELTERELIESSEVTDRLFDELHALGVKIAIDDFGTAYLRKFQVDCLKIDQSFVARIGIDTLSGHILDSIVELSAKLDLDIVAEGVETPEQRDYLAARGVDYLQGYLIGRPMPLESLLSSLTVQEGQG 4y8e A 1.61 BS02 CA A 2 Q25 E217 G218 Q237 G238 Q23 E210 G211 Q230 G231 RVASPSSELRRALEANEFIPYYQPLSPGQGGRWIGVEVLMRWRHPREGLIRPDLFIPFAERSGLIVPMTRALMRQVAEDLGGHAGKLEPGFHIGFNISATHCHELALVDDCRELLAAFPPGHITLVLELTERELIESSEVTDRLFDELHALGVKIAIDDFGTAYLRKFQVDCLKIDQSFVARIGIDTLSGHILDSIVELSAKLDLDIVAEGVETPEQRDYLAARGVDYLQGYLIGRPMPLESLLSSLTVQEGQG 4y8e A 1.61 BS03 CA A 3 D160 D161 E217 D158 D159 E210 RVASPSSELRRALEANEFIPYYQPLSPGQGGRWIGVEVLMRWRHPREGLIRPDLFIPFAERSGLIVPMTRALMRQVAEDLGGHAGKLEPGFHIGFNISATHCHELALVDDCRELLAAFPPGHITLVLELTERELIESSEVTDRLFDELHALGVKIAIDDFGTAYLRKFQVDCLKIDQSFVARIGIDTLSGHILDSIVELSAKLDLDIVAEGVETPEQRDYLAARGVDYLQGYLIGRPMPLESLLSSLTVQEGQG 4y9r A 2.40 BS01 FMN A 1 S86 Q87 T88 G89 T90 A91 A138 T139 Y140 E142 G143 L173 G174 N175 Y178 H180 F181 N182 D208 L212 S25 Q26 T27 G28 T29 A30 A77 T78 Y79 E80 G81 L111 G112 N113 Y116 H118 F119 N120 D146 L150 1.6.2.4 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATSSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPARALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4y9r A 2.40 BS03 NAP A 1 R298 G534 T535 C566 S596 R597 K602 Y604 Q606 M636 D639 R233 G464 T465 C496 S526 R527 K532 Y534 Q536 M566 D569 1.6.2.4 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATSSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPARALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4y9u A 1.95 BS01 FMN A 1 S86 Q87 T88 G89 T90 A91 A138 T139 Y140 L173 G174 N175 Y178 H180 F181 N182 D208 L212 S25 Q26 T27 G28 T29 A30 A77 T78 Y79 L108 G109 N110 Y113 H115 F116 N117 D143 L147 1.6.2.4 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATEESSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yal A 1.88 BS03 2AM A 1 G534 C566 S596 R597 K602 Y604 Q606 N635 M636 D639 G464 C496 S526 R527 K532 Y534 Q536 N565 M566 D569 1.6.2.4 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPARALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yao A 2.50 BS03 2AM A 1 G534 C566 R567 S596 R597 K602 Y604 Q606 M636 D639 G458 C490 R491 S520 R521 K526 Y528 Q530 M560 D563 1.6.2.4 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEARQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPARALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yao B 2.50 BS01 FMN B 1 S86 Q87 T88 G89 T90 A91 A138 T139 L173 G174 N175 Y178 F181 N182 L212 S20 Q21 T22 G23 T24 A25 A72 T73 L101 G102 N103 Y106 F109 N110 L140 1.6.2.4 SSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEAIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yao B 2.50 BS03 2AM B 1 C566 S596 R597 K602 Y604 Q606 N635 M636 D639 C484 S514 R515 K520 Y522 Q524 N553 M554 D557 1.6.2.4 SSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEAIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4ybj A 2.61 BS01 4A9 A 1 L273 V281 A293 K295 E310 M314 L317 L322 I336 T338 E339 Y340 M341 S342 K343 G344 H384 L393 V402 A403 D404 F405 L15 V21 A33 K35 E50 M54 L57 L62 I76 T78 E79 Y80 M81 S82 K83 G84 H124 L133 V142 A143 D144 F145 2.7.10.2 26895387 AWEIPRESLRLEVKLGQGGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 4ybj B 2.61 BS01 4A9 B 1 L273 A293 K295 E310 M314 L322 I336 T338 E339 Y340 M341 S342 K343 G344 H384 L393 V402 A403 D404 F405 L15 A35 K37 E47 M51 L59 I73 T75 E76 Y77 M78 S79 K80 G81 H121 L130 V139 A140 D141 F142 2.7.10.2 26895387 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 4ybk A 2.50 BS01 4B7 A 1 L273 V281 A293 K295 M314 I336 T338 E339 Y340 M341 S342 K343 G344 L393 D404 F405 L407 L18 V26 A38 K40 M59 I81 T83 E84 Y85 M86 S87 K88 G89 L138 D149 F150 L152 2.7.10.2 26895387 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 4yc8 A 2.90 BS01 4B7 A 1 L248 A269 K271 F283 E286 A287 M290 I313 T315 E316 F317 M318 T319 Y320 G321 L370 F382 L16 A31 K33 F41 E44 A45 M48 I71 T73 E74 F75 M76 T77 Y78 G79 L128 F140 2.7.10.2 26895387 DKWEMERTDITMKHKLEVYEGVWKKYSLTVAVKTLMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS 4yc8 B 2.90 BS01 4B7 B 1 L248 A269 K271 F283 E286 M290 I313 T315 E316 F317 M318 T319 Y320 G321 F382 L16 A31 K33 F45 E48 M52 I75 T77 E78 F79 M80 T81 Y82 G83 F144 2.7.10.2 26895387 DKWEMERTDITMKHKLEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSI 4yct A 1.13 BS01 FBF A 1 D35 G37 S38 Y79 I217 D219 I300 I302 D35 G37 S38 Y79 I215 D217 I298 I300 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4ycy A 1.70 BS01 4AO A 1 D35 G37 I77 D219 D35 G37 I77 D212 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4yd3 A 1.25 BS01 4AQ A 1 D15 D119 T223 F291 D15 D119 T223 F291 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4yd3 A 1.25 BS02 4AQ A 2 D33 Y79 D81 S83 S115 F116 D33 Y79 D81 S83 S115 F116 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4yd4 A 1.27 BS01 4AY A 1 D279 G281 P282 C290 D279 G281 P282 C290 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4yd5 A 1.21 BS01 4AV A 1 D33 D35 G37 Y79 G80 D81 L125 D219 G221 T222 D33 D35 G37 Y79 G80 D81 L125 D219 G221 T222 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4yd6 A 1.30 BS01 4AS A 1 D33 Y79 D81 S83 S115 F116 I122 D33 Y79 D81 S83 S115 F116 I122 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4yd7 A 1.42 BS01 F5N A 1 D35 Y79 G80 D81 L125 F194 I217 D219 G221 I300 I302 I304 D35 Y79 G80 D81 L125 F194 I217 D219 G221 I300 I302 I304 3.4.23.22 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 4yek A 2.55 BS01 THM A 1 T87 Y168 R171 V177 I183 S186 I187 F210 T87 Y168 R171 V177 I183 S186 I187 F210 2.4.2.4 MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLNLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTEGFISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRPLAVIHAKDEASWQEAAKAVKAAIILDDKAPASTPSVYRRITE 4yek A 2.55 BS02 THM A 2 S248 S249 R257 E258 Q261 Y267 T384 D385 S248 S249 R257 E258 Q261 Y267 T384 D385 2.4.2.4 MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLNLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTEGFISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRPLAVIHAKDEASWQEAAKAVKAAIILDDKAPASTPSVYRRITE 4yek B 2.55 BS01 THM B 1 S248 S249 E258 Q261 Y267 T384 D385 S248 S249 E258 Q261 Y267 T384 D385 2.4.2.4 MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLNLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTEGFISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRPLAVIHAKDEASWQEAAKAVKAAIILDDKAPASTPSVYRRITE 4yek B 2.55 BS02 THM B 2 H85 T87 Y168 R171 V177 S186 K190 F210 H85 T87 Y168 R171 V177 S186 K190 F210 2.4.2.4 MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLNLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTEGFISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRPLAVIHAKDEASWQEAAKAVKAAIILDDKAPASTPSVYRRITE 4yf9 A 2.60 BS01 III B 1 T77 A162 G163 N167 T66 A151 G152 N156 TYSAEIRRTTMGVPHIKAGNWGSAGYGFGYVQAQDNLCTMADSFLTYRGERSRHLGGSAQLVYNSTLGRPRNIDSDFFHRHVISDEAVDRTMAAQPAKLLQMVEGFAAGYNRYVREAKAGGSAHAACRSEAWVQPITARDVWRRIYAANLAGGYSNFAEAIANAQPP 4yf9 A 2.60 BS02 III E 1 R82 Q176 R71 Q165 TYSAEIRRTTMGVPHIKAGNWGSAGYGFGYVQAQDNLCTMADSFLTYRGERSRHLGGSAQLVYNSTLGRPRNIDSDFFHRHVISDEAVDRTMAAQPAKLLQMVEGFAAGYNRYVREAKAGGSAHAACRSEAWVQPITARDVWRRIYAANLAGGYSNFAEAIANAQPP 4yf9 C 2.60 BS01 III B 1 W24 Y25 V70 R74 G136 L137 N138 P139 L141 W189 F225 A228 A232 A504 W24 Y25 V70 R74 G136 L137 N138 P139 L141 W189 F225 A228 A232 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yf9 D 2.60 BS02 III E 1 A162 G163 N167 A152 G153 N157 STYSAEIRRTTMGVPHIKAGNWGSAGYGFGYVQAQDNLCTMADSFLTYRGERSRHLGGSAQLVYNSTLGRPRNIDSDFFHRHVISDEAVDRTMAAQPAKLLQMVEGFAAGYNRYVREAKAGGSAHAACRSEAWVQPITARDVWRRIYAANLAGGYSNFAEAIANAQPP 4yf9 F 2.60 BS01 III E 1 W24 V70 F76 G136 L137 N138 P139 L141 W189 A228 A232 A504 W24 V70 F76 G136 L137 N138 P139 L141 W189 A228 A232 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yf9 G 2.60 BS01 III H 1 A162 G163 N167 F168 A151 G152 N156 F157 TYSAEIRRTTMGVPHIKAGNWGSAGYGFGYVQAQDNLCTMADSFLTYRGERSRHLGGSAQLVYNSTLGRPRNIDSDFFHRHVISDEAVDRTMAAQPAKLLQMVEGFAAGYNRYVREAKAGGSAHAACRSEAWVQPITARDVWRRIYAANLAGGYSNFAEAIANAQPP 4yf9 I 2.60 BS01 III H 1 W24 Y25 V70 R74 F76 G136 L137 N138 P139 A140 L141 W189 A228 A232 A504 W24 Y25 V70 R74 F76 G136 L137 N138 P139 A140 L141 W189 A228 A232 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKEL 4yf9 L 2.60 BS01 III K 1 W24 Y25 V70 R74 F76 G136 L137 N138 P139 A228 A232 L233 A504 W24 Y25 V70 R74 F76 G136 L137 N138 P139 A228 A232 L233 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfa A 2.20 BS01 III B 1 T77 A162 G163 T66 A151 G152 TYSAEIRRTTMGVPHIKAGNWGSAGYGFGYVQAQDNLCTMADSFLTYRGERSRHLGGSAQLVYNSTLGRPRNIDSDFFHRHVISDEAVDRTMAAQPAKLLQMVEGFAAGYNRYVREAKAGGSAHAACRSEAWVQPITARDVWRRIYAANLAGGYSNFAEAIANAQPP 4yfa C 2.20 BS01 III B 1 W24 Y25 V70 R74 F76 G136 L137 N138 P139 W189 F225 A228 A232 N503 A504 W24 Y25 V70 R74 F76 G136 L137 N138 P139 W189 F225 A228 A232 N503 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKEL 4yfa C 2.20 BS02 DKA C 1 S1 H23 W24 F32 F50 Q57 I58 H68 T69 V70 W165 W189 V190 S1 H23 W24 F32 F50 Q57 I58 H68 T69 V70 W165 W189 V190 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKEL 4yfa F 2.20 BS01 III E 1 Y25 V70 F76 G136 L137 N138 P139 L141 W189 A228 A232 L233 A504 Y25 V70 F76 G136 L137 N138 P139 L141 W189 A228 A232 L233 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKEL 4yfa F 2.20 BS02 DKA F 1 S1 P22 W24 F50 Q57 I58 T69 V70 W165 W189 N278 S1 P22 W24 F50 Q57 I58 T69 V70 W165 W189 N278 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKEL 4yfa I 2.20 BS01 III H 1 W24 Y25 V70 R74 F76 G136 L137 N138 P139 A140 L141 A228 V229 A232 N503 A504 W24 Y25 V70 R74 F76 G136 L137 N138 P139 A140 L141 A228 V229 A232 N503 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKEL 4yfa I 2.20 BS02 DKA I 1 S1 P22 W24 F32 F50 Q57 I58 H68 T69 V70 W165 P188 W189 V190 S1 P22 W24 F32 F50 Q57 I58 H68 T69 V70 W165 P188 W189 V190 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKEL 4yfa L 2.20 BS02 DKA L 1 S1 P22 W24 F32 F50 I58 H68 T69 V70 W165 W189 V190 N278 S1 P22 W24 F32 F50 I58 H68 T69 V70 W165 W189 V190 N278 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfb A 1.75 BS01 III B 1 A162 N167 F168 A152 N157 F158 STYSAEIRRTTMGVPHIKAGNWGSAGYGFGYVQAQDNLCTMADSFLTYRGERSRHLGGSAQLVYNSTLGRPRNIDSDFFHRHVISDEAVDRTMAAQPAKLLQMVEGFAAGYNRYVREAKAGGSAHAACRSEAWVQPITARDVWRRIYAANLAGGYSNFAEAIANAQPP 4yfb C 1.75 BS01 III B 1 W24 Y25 V70 R74 F76 L137 N138 P139 A140 W189 F225 A228 V229 A232 A504 W24 Y25 V70 R74 F76 L137 N138 P139 A140 W189 F225 A228 V229 A232 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfb C 1.75 BS02 III E 1 V119 R121 T122 L123 V119 R121 T122 L123 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfb C 1.75 BS03 PAC C 1 S1 W24 F50 I58 H68 T69 V70 W189 V190 S1 W24 F50 I58 H68 T69 V70 W189 V190 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfb D 1.75 BS01 III B 1 R82 N174 Q176 R72 N164 Q166 STYSAEIRRTTMGVPHIKAGNWGSAGYGFGYVQAQDNLCTMADSFLTYRGERSRHLGGSAQLVYNSTLGRPRNIDSDFFHRHVISDEAVDRTMAAQPAKLLQMVEGFAAGYNRYVREAKAGGSAHAACRSEAWVQPITARDVWRRIYAANLAGGYSNFAEAIANAQPP 4yfb F 1.75 BS01 III B 1 T120 R121 T120 R121 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfb F 1.75 BS02 III E 1 W24 Y25 V70 R74 F76 G136 L137 N138 P139 A140 W189 F225 A228 A232 L233 A504 W24 Y25 V70 R74 F76 G136 L137 N138 P139 A140 W189 F225 A228 A232 L233 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfb F 1.75 BS03 PAC F 1 S1 P22 W24 F32 F50 H68 T69 V70 V190 S1 P22 W24 F32 F50 H68 T69 V70 V190 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfb I 1.75 BS01 III H 1 W24 Y25 V70 R74 F76 G136 L137 N138 P139 W189 A228 V229 A232 A504 W24 Y25 V70 R74 F76 G136 L137 N138 P139 W189 A228 V229 A232 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfb I 1.75 BS02 PAC I 1 S1 P22 W24 F32 F50 H68 T69 V70 W189 V190 S1 P22 W24 F32 F50 H68 T69 V70 W189 V190 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKELE 4yfb L 1.75 BS01 III K 1 W24 Y25 V70 R74 G136 L137 N138 P139 A140 W189 F225 A228 V229 A232 N503 A504 W24 Y25 V70 R74 G136 L137 N138 P139 A140 W189 F225 A228 V229 A232 N503 A504 SNMYGFGTAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWSHTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSEFGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASIPWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECDWLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTLRTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTVNGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGINAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCSENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSAGQWLRVPFTEAEITGNADYRTATVKEL 4yfp A 1.95 BS01 RET A 1 F15 A36 Y39 I52 V54 T56 V76 W109 K111 L121 M123 F15 A36 Y39 I52 V54 T56 V76 W109 K111 L121 M123 PNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKYAVEIKQEGDTFYIKVSTTVYTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTKELTNDGELILTMTADDVVCTQVFVRE 4ygh A 2.10 BS01 RET A 1 F15 Y39 T56 V76 W109 K111 L121 F15 Y39 T56 V76 W109 K111 L121 PNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKYAVEIKQEGDTFYIKVSTTVYTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTKELTNDGELILTMTADDVVCTQVFVRE 4ygz A 2.06 BS01 RET A 1 F15 Y39 I52 V54 T56 V76 W109 K111 L121 M123 F15 Y39 I52 V54 T56 V76 W109 K111 L121 M123 PNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKYAVEIKQEGDTFYIKVSTTVYTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTKELTNDGELILTMTADDVVCTQVFVRE 4yh0 A 2.14 BS01 RET A 1 F15 A36 Y39 T56 V76 W109 K111 L121 F15 A36 Y39 T56 V76 W109 K111 L121 PNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKYAVEIKQEGDTFYIKVSTTVYTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTKELTNDGELILTMTADDVVCTQVFVRE 4yia A 1.58 BS01 CA A 1 N192 Q220 E222 N174 Q202 E204 LYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPR 4yia A 1.58 BS02 IMN B 1 S23 S24 Q238 L246 S266 L269 W272 N273 L276 S5 S6 Q220 L228 S248 L251 W254 N255 L258 LYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPR 4yia A 1.58 BS03 CA B 1 N26 A27 N8 A9 LYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPR 4yia B 1.58 BS01 IMN B 1 L376 R378 R381 L15 R17 R20 HPIIQIDRSFMLLILERSTRSILFLGKVVNPTE 4yia B 1.58 BS02 CA B 1 S382 I383 S21 I22 HPIIQIDRSFMLLILERSTRSILFLGKVVNPTE 4yo0 A 1.56 BS01 III E 1 N50 Y51 G52 S71 A72 K76 Y78 T118 S119 R120 V121 Y122 N31 Y32 G33 S52 A53 K57 Y59 T99 S100 R101 V102 Y103 26872787 EVQLVESGGGLVQPGRSLKLSCAASGFTFSNYGMAWVRQTPTKGLEWIASISAGGDKTYYGDSVKGRFSISRDNAKTTHYLQMDSLRSEDTATYYCAKTSRVYFDYWGQGVMVTVSSAETTAPSVYPLAPSMVTLGCLVKGYFPEPVTVTWNSGALSSGVHTFPAVLQSGLYTLTSSVTVPSSTWSSQAVTCNVAHPASSTKVDKKIVP 4yo0 B 1.56 BS01 III E 1 Y52 H111 Y113 S114 S115 I117 Y32 H91 Y93 S94 S95 I97 26872787 FVLTQPNSVSTNLGSTVKLSCKRSTGNIGSNYVNWYQQHEGRSPTTMIYRDDKRPDGVPDRFSGSIDRSSNSALLTINNVQTEDEADYFCHSYSSGIVFGGGTKLTVLGQPKSTPTLTVFPPSTEELQGNKATLVCLISDFYPSDVEVAWKANGAPISQGVDTANPTKQGNKYIASSFLRLTAEQWRSRNSFTCQVTHEGNTVEKSLSP 4yo0 C 1.56 BS01 III F 1 N50 Y51 G52 S69 S71 K76 Y78 T118 S119 R120 V121 F123 N31 Y32 G33 S50 S52 K57 Y59 T99 S100 R101 V102 F104 26872787 EVQLVESGGGLVQPGRSLKLSCAASGFTFSNYGMAWVRQTPTKGLEWIASISAGGDKTYYGDSVKGRFSISRDNAKTTHYLQMDSLRSEDTATYYCAKTSRVYFDYWGQGVMVTVSSAETTAPSVYPLAPMVTLGCLVKGYFPEPVTVTWNSGALSSGVHTFPAVLQSGLYTLTSSVTVTCNVAHPASSTKVDKKIVP 4yo0 D 1.56 BS01 III F 1 H111 Y113 S114 S115 I117 H91 Y93 S94 S95 I97 26872787 FVLTQPNSVSTNLGSTVKLSCKRSTGNIGSNYVNWYQQHEGRSPTTMIYRDDKRPDGVPDRFSGSIDRSSNSALLTINNVQTEDEADYFCHSYSSGIVFGGGTKLTVLGQPKSTPTLTVFPPSTEELQGNKATLVCLISDFYPSDVEVAWKANGAPISQGVDTANPTKQGNKYIASSFLRLTAEQWRSRNSFTCQVTHEGNTVEKSLSP 4yt1 B 2.20 BS01 JJB B 1 H266 I281 C285 R288 S289 A292 E295 I326 Y327 M329 L330 L333 I341 F363 M364 H57 I64 C68 R71 S72 A75 E78 I109 Y110 M112 L113 L116 I124 F146 M147 26025876 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKKSPFVIYDMNSLMMGEDKIKFKHKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYK 4ywr A 1.65 BS01 PLP A 1 A25 G26 Q51 M87 D112 A117 N118 L123 S216 A16 G17 Q42 M78 D103 A108 N109 L114 S198 RPTVLCFSGLDPSGGAGLQADIEAIGQSGAHAAIACTALTIQNSQQVFGFEATSKELLLAQANAVVGDLPIKCVKSGMLGTTDNIAALAEFLRAHPDYQYVLDPVLVANSGGSLGDQATLVKAFVELIPLATLITPNTVELRALTGVTDLDQATQKLFEMGAKAVLVKGGHEDTPDFIKNSLYIDGELAASSTCPRCSLASFIAGRLALGDSLKIAVQHAETWLFGVL 4yxd A 3.00 BS01 FAD A 1 G26 A27 G28 G29 A30 T49 K50 L51 S56 H57 T58 A60 A61 G63 G64 Y177 F178 A179 A213 T214 G215 T225 D233 L264 H365 Y366 G397 E398 R409 A412 S414 L415 L418 G17 A18 G19 G20 A21 T40 K41 L42 S47 H48 T49 A51 A52 G54 G55 Y168 F169 A170 A204 T205 G206 T216 D224 L255 H356 Y357 G388 E389 R400 A403 S405 L406 L409 1.3.5.1 26198225 STQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRARNTVVATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLAVRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHVNGQDQVVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKPNAGEESVMNLDKLRFANGTIRTSELRLSMQKSMQSHAAVFRVGSVLQEGCEKILRLYGDLQHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDFKERVDEYDYSKPIQGQQKKPFQEHWRKHTLSYVDVKTGKVSLEYRPVIDKTLNEADCATVPPAIRSY 4yxd B 3.00 BS02 SF4 B 1 C158 I159 L160 C161 A162 C163 C164 A182 C225 P226 L229 C150 I151 L152 C153 A154 C155 C156 A174 C217 P218 L221 1.3.5.1 26198225 PRIKKFAIYRWDPDKTGDKPHMQTYEIDLNNCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLDKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTGTCPKGLNPGKAIAEIKKMMATYKE 4yxd B 3.00 BS03 F3S B 1 C168 Y178 C215 H216 T217 I218 M219 N220 C221 G232 C160 Y170 C207 H208 T209 I210 M211 N212 C213 G224 1.3.5.1 26198225 PRIKKFAIYRWDPDKTGDKPHMQTYEIDLNNCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLDKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTGTCPKGLNPGKAIAEIKKMMATYKE 4yxd D 3.00 BS01 HEM C 1 S50 L54 H79 G83 S16 L20 H45 G49 26198225 SSKAASLHWTGERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGIGQVVTDYVRGDALQKVAKAGLLALSAFTFAGLCYFNYHDVGICKAVAMLWKL 4z5w A 2.20 BS01 III Q 1 R310 A334 S335 N356 A358 K359 S380 S382 T408 I431 A433 S434 L453 D455 S457 W458 Y477 F513 F515 F516 K517 K518 G525 F534 R284 A308 S309 N330 A332 K333 S354 S356 T382 I405 A407 S408 L427 D429 S431 W432 Y451 F479 F481 F482 K483 K484 G485 F494 2.7.11.1 26308901 LTCNSNDLKALEGFMRGLESSIDGWKWNESSSFSSNCCDWVGISCKSSVSLGLDDVNESGRVVELELGRRKLSGKLSESVAKLDQLKVLNLTHNSLSGSIAASLLNLSNLEVLDLSSNDFSGLFPSLINLPSLRVLNVYENSFHGLIPASLCNNLPRIREIDLAMNYFDGSIPVGIGNCSSVEYLGLASNNLSGSIPQELFQLSNLSVLALQNNRLSGALSSKLGKLSNLGRLDISSNKFSGKIPDVFLELNKLWYFSAQSNLFNGEMPRSLSNSRSISLLSLRNNTLSGQIYLNCSAMTNLTSLDLASNSFSGSIPSNLPNCLRLKTINFAKIKFIAQIPESFKNFQSLTSLSFSNSSIQNISSALEILQHCQNLKTLVLTLNFQKEELPSVPSLQFKNLKVLIIASCQLRGTVPQWLSNSPSLQLLDLSWNQLSGTIPPWLGSLNSLFYLDLSNNTFIGEIPHSLTSLQSLVSKPDFPFFKKGLQYNQPSSFPPMIDLSYNSLNGSIWPEFGDLRQLHVLNLKNNNLSGNIPANLSGMTSLEVLDLSHNNLSGNIPPSLVKLSFLSTFSVAYNKLSGPIPFQTFPNSSFEGNQG 4z5w B 2.20 BS01 III P 1 R310 A334 S335 N356 A358 K359 S380 S382 T408 L409 I431 A433 S434 L453 D455 S457 W458 Y477 F515 F516 K517 K518 F534 R278 A302 S303 N324 A326 K327 S348 S350 T376 L377 I399 A401 S402 L421 D423 S425 W426 Y445 F474 F475 K476 K477 F486 2.7.11.1 26308901 LTCNSNDLKALEGFMRGLESSIDGWKWNFSSNCCDWVGISCKSSVSLGLVNESGRVVELELGRRKLSGKLSESVAKLDQLKVLNLTHNSLSGSIAASLLNLSNLEVLDLSSNDFSGLFPSLINLPSLRVLNVYENSFHGLIPASLCNNLPRIREIDLAMNYFDGSIPVGIGNCSSVEYLGLASNNLSGSIPQELFQLSNLSVLALQNNRLSGALSSKLGKLSNLGRLDISSNKFSGKIPDVFLELNKLWYFSAQSNLFNGEMPRSLSNSRSISLLSLRNNTLSGQIYLNCSAMTNLTSLDLASNSFSGSIPSNLPNCLRLKTINFAKIKFIAQIPESFKNFQSLTSLSFSNSSIQNISSALEILQHCQNLKTLVLTLNFQKEELPSVPSLQFKNLKVLIIASCQLRGTVPQWLSNSPSLQLLDLSWNQLSGTIPPWLGSLNSLFYLDLSNNTFIGEIPHSLTSLQSLVSKDFPFFKKLQYNQPSSFPPMIDLSYNSLNGSIWPEFGDLRQLHVLNLKNNNLSGNIPANLSGMTSLEVLDLSHNNLSGNIPPSLVKLSFLSTFSVAYNKLSGPIPTGVQFQTFPNSSFEGNQGLCGEHASPC 4z61 A 2.75 BS01 III Q 1 R310 A334 S335 N356 A358 S380 S382 T408 I431 A433 S434 D455 S457 W458 P514 F515 F516 K518 G525 F534 R284 A308 S309 N330 A332 S354 S356 T382 I405 A407 S408 D429 S431 W432 P480 F481 F482 K484 G486 F495 2.7.11.1 26308901 LTCNSNDLKALEGFMRGLESSIDGWKWNESSSFSSNCCDWVGISCKSSVSLGLDDVNESGRVVELELGRRKLSGKLSESVAKLDQLKVLNLTHNSLSGSIAASLLNLSNLEVLDLSSNDFSGLFPSLINLPSLRVLNVYENSFHGLIPASLCNNLPRIREIDLAMNYFDGSIPVGIGNCSSVEYLGLASNNLSGSIPQELFQLSNLSVLALQNNRLSGALSSKLGKLSNLGRLDISSNKFSGKIPDVFLELNKLWYFSAQSNLFNGEMPRSLSNSRSISLLSLRNNTLSGQIYLNCSAMTNLTSLDLASNSFSGSIPSNLPNCLRLKTINFAKIKFIAQIPESFKNFQSLTSLSFSNSSIQNISSALEILQHCQNLKTLVLTLNFQKEELPSVPSLQFKNLKVLIIASCQLRGTVPQWLSNSPSLQLLDLSWNQLSGTIPPWLGSLNSLFYLDLSNNTFIGEIPHSLTSLQSLVSKPDFPFFKKGGLQYNQPSSFPPMIDLSYNSLNGSIWPEFGDLRQLHVLNLKNNNLSGNIPANLSGMTSLEVLDLSHNNLSGNIPPSLVKLSFLSTFSVAYNKLSGPIPTGVQFQTFPNSSFEGNQGLCGEHASPC 4z63 A 2.51 BS01 III P 1 R300 G324 T325 N346 A348 S370 S372 V396 T398 L399 V421 A423 N424 L443 D445 S447 W448 Y467 F503 P504 F506 M507 K508 E511 A515 F524 R271 G295 T296 N317 A319 S341 S343 V367 T369 L370 V392 A394 N395 L414 D416 S418 W419 Y438 F474 P475 F477 M478 K479 E482 A486 F495 2.7.11.1 26308901 RCHPHDLEALRDFIAHLEPKPDGWINSSSSTDCCNWTGITCNSNNTGRVIRLELGNKKLSGKLSESLGKLDEIRVLNLSRNFIKDSIPLSIFNLKNLQTLDLSSNDLSGGIPTSINLPALQSFDLSSNKFNGSLPSHICHNSTQIRVVKLAVNYFAGNFTSGFGKCVLLEHLCLGMNDLTGNIPEDLFHLKRLNLLGIQENRLSGSLSREIRNLSSLVRLDVSWNLFSGEIPDVFDELPQLKFFLGQTNGFIGGIPKSLANSPSLNLLNLRNNSLSGRLMLNCTAMIALNSLDLGTNRFNGRLPENLPDCKRLKNVNLARNTFHGQVPESFKNFESLSYFSLSNSSLANISSALGILQHCKNLTTLVLTLNFHGEALPDDSSLHFEKLKVLVVANCRLTGSMPRWLSSSNELQLLDLSWNRLTGAIPSWIGDFKALFYLDLSNNSFTGEIPKSLTKLESLTSRNISVNEPSPDFPFFMKRNESARALQYNQIFGFPPTIELGHNNLSGPIWEEFGNLKKLHVFDLKWNALSGSIPSSLSGMTSLEALDLSNNRLSGSIPVSLQQLSFLSKFSVAYNNLSGVIPSGGQFQTFPNSSFESNHLCGEHRFPCS 4z64 A 2.66 BS01 III P 1 G324 T325 N346 A348 R349 S370 S372 V396 T398 V421 N424 D445 S447 Y467 F506 K508 E511 A515 G290 T291 N312 A314 R315 S336 S338 V362 T364 V387 N390 D411 S413 Y433 F472 K474 E477 A481 2.7.11.1 26308901 RCHPHDLEALRDFIAHLEPKPDGWINSSSSTDCCNWTGITCNRVIRLELGNKKLSGKLSESLGKLDEIRVLNLSRNFIKDSIPLSIFNLKNLQTLDLSSNDLSGGIPTSINLPALQSFDLSSNKFNGSLPSHICHNSTQIRVVKLAVNYFAGNFTSGFGKCVLLEHLCLGMNDLTGNIPEDLFHLKRLNLLGIQENRLSGSLSREIRNLSSLVRLDVSWNLFSGEIPDVFDELPQLKFFLGQTNGFIGGIPKSLANSPSLNLLNLRNNSLSGRLMLNCTAMIALNSLDLGTNRFNGRLPENLPDCKRLKNVNLARNTFHGQVPESFKNFESLSYFSLSNSSLANISSALGILQHCKNLTTLVLTLNFHGEALPDDSSLHFEKLKVLVVANCRLTGSMPRWLSSSNELQLLDLSWNRLTGAIPSWIGDFKALFYLDLSNNSFTGEIPKSLTKLESLTSRNISVNEPSPDFPFFMKRNESARALQYNQIFGFPPTIELGHNNLSGPIWEEFGNLKKLHVFDLKWNALSGSIPSSLSGMTSLEALDLSNNRLSGSIPVSLQQLSFLSKFSVAYNNLSGVIPSGGQFQTFPNSSFESNHLCGEHRFPCS 4z64 A 2.66 BS02 SO4 A 1 W253 Q276 R300 W219 Q242 R266 2.7.11.1 26308901 RCHPHDLEALRDFIAHLEPKPDGWINSSSSTDCCNWTGITCNRVIRLELGNKKLSGKLSESLGKLDEIRVLNLSRNFIKDSIPLSIFNLKNLQTLDLSSNDLSGGIPTSINLPALQSFDLSSNKFNGSLPSHICHNSTQIRVVKLAVNYFAGNFTSGFGKCVLLEHLCLGMNDLTGNIPEDLFHLKRLNLLGIQENRLSGSLSREIRNLSSLVRLDVSWNLFSGEIPDVFDELPQLKFFLGQTNGFIGGIPKSLANSPSLNLLNLRNNSLSGRLMLNCTAMIALNSLDLGTNRFNGRLPENLPDCKRLKNVNLARNTFHGQVPESFKNFESLSYFSLSNSSLANISSALGILQHCKNLTTLVLTLNFHGEALPDDSSLHFEKLKVLVVANCRLTGSMPRWLSSSNELQLLDLSWNRLTGAIPSWIGDFKALFYLDLSNNSFTGEIPKSLTKLESLTSRNISVNEPSPDFPFFMKRNESARALQYNQIFGFPPTIELGHNNLSGPIWEEFGNLKKLHVFDLKWNALSGSIPSSLSGMTSLEALDLSNNRLSGSIPVSLQQLSFLSKFSVAYNNLSGVIPSGGQFQTFPNSSFESNHLCGEHRFPCS 4zib A 2.05 BS03 4OG A 1 M300 L301 A302 L305 M344 S399 V401 A420 M109 L110 A111 L114 M153 S202 V204 A223 6.1.1.26 26582921 PALTKSQTDRLEVLLNPKDESGKPFRELESELLSRRKKDLQQIYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLGFQQMGSGCTRENLESIITDFLNHLGIDFKIVGGDTLDVMHGDLELSSAVVGPIPLDREWGIDKPWIGAGFGLERLLKVKHDFKNIKRAARSESYYNGISTNL 4zic C 2.55 BS01 NAP C 1 T15 G16 A17 V18 S40 L87 D88 P89 A91 N109 A110 C154 G186 G188 N340 G344 A345 T10 G11 A12 V13 S35 L82 D83 P84 A86 N104 A105 C149 G181 G183 N335 G339 A340 1.2.1.11 26869335 KKRCGVLGATGAVGTRFILLLSQHPLLELVAVGASDRSSGKKYRDAVRWKQSAPMPAKVADLTVRCCDPAEFSDCDIIFSGLDPDAAGEIEMAFLKANFAVFSNAKNYRLDPMVPLVVPLVNAGHIDVIPAQRKHFGLDKGMLVCNSNCAVVGLVVPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPYIPGEEGKISSEARKILGDLNSDLAGFSDQKPLQISVACNRVPVLDGHTVCASLRFVNRPPPTASQVREALREYKPEVQTLGCPSAPKMSIHVMDEVDRPQPRLDRETEGGYACTVGRIREDDSDVFDIQFVALSHNTVLGASGSSILNAESAILKGFV 4zic A 2.55 BS01 NAP A 1 T15 G16 A39 S40 D88 P89 A91 N109 R114 C154 G186 G188 Y189 N340 G344 A345 T10 G11 A34 S35 D80 P81 A83 N101 R106 C146 G178 G180 Y181 N332 G336 A337 1.2.1.11 26869335 KKRCGVLGATGAVGTRFILLLSQHPLLELVAVGASSGKKYRDAVRWKQSAPMPAKVADLTVRCCDPAEFSDCDIIFSGLDPDAAGEIEMAFLKANFAVFSNAKNYRLDPMVPLVVPLVNAGHIDVIPAQRKHFGLDKGMLVCNSNCAVVGLVVPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPYIPGEEGKISSEARKILGDLNSDLAGFSDQKPLQISVACNRVPVLDGHTVCASLRFVNRPPPTASQVREALREYKPEVQTLGCPSAPKMSIHVMDEVDRPQPRLDRETEGGYACTVGRIREDDSDVFDIQFVALSHNTVLGASGSSILNAESAILKGFV 4zkl B 2.34 BS01 AMP B 1 F19 F41 H42 D43 I44 N99 G105 Q106 S107 H112 H114 F7 F29 H30 D31 I32 N87 G93 Q94 S95 H100 H102 3.-.-.- PGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG 4zkl B 2.34 BS02 JB6 B 1 I22 F41 H42 D43 I44 S45 G105 S107 V108 H112 H114 I10 F29 H30 D31 I32 S33 G93 S95 V96 H100 H102 3.-.-.- PGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG 4zkl D 2.34 BS01 AMP D 1 F19 F41 H42 D43 I44 S45 N99 G105 Q106 S107 V108 H112 H114 F6 F28 H29 D30 I31 S32 N86 G92 Q93 S94 V95 H99 H101 3.-.-.- GGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG 4zzb A 3.40 BS01 XE A 1 F207 I208 I211 F203 I204 I207 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzb A 3.40 BS02 XE A 2 L232 Y263 Y266 F267 L228 Y259 Y262 F263 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzb A 3.40 BS03 XE A 3 Y197 M205 T255 I258 I259 Y193 M201 T251 I254 I255 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzb A 3.40 BS04 XE A 4 F37 L126 I128 F165 L188 F33 L122 I124 F161 L184 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzb A 3.40 BS05 XE A 5 A298 F299 V302 A294 F295 V298 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzb B 3.40 BS03 XE B 2 M205 T255 I258 I259 M201 T251 I254 I255 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzb B 3.40 BS04 XE B 3 F37 L126 H127 I128 F165 Y186 Q187 L188 F33 L122 H123 I124 F161 Y182 Q183 L184 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzb C 3.40 BS01 XE B 1 L232 Y263 Y266 L228 Y259 Y262 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzb E 3.40 BS01 XE A 6 F207 I211 F203 I207 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzb E 3.40 BS04 XE E 2 F37 L126 H127 I128 F165 L188 F33 L122 H123 I124 F161 L184 VSPPPPIADEPLTVNTGIYLIESYSLDDCAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNCPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc A 3.10 BS01 XE A 1 V229 L232 I233 V225 L228 I229 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc A 3.10 BS02 XE A 2 P120 Y197 I201 T255 P116 Y193 I197 T251 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc A 3.10 BS03 XE A 3 F121 I202 Y254 T255 I258 F117 I198 Y250 T251 I254 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc A 3.10 BS04 XE A 4 V225 V228 V270 V273 V221 V224 V266 V269 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc A 3.10 BS05 XE A 5 F37 I128 F165 Y186 L188 F33 I124 F161 Y182 L184 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc A 3.10 BS06 XE A 6 V268 F299 V302 V264 F295 V298 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc A 3.10 BS07 XE B 1 S230 T231 A234 S226 T227 A230 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc B 3.10 BS02 XE B 2 P120 Y197 I201 I202 T255 P116 Y193 I197 I198 T251 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc B 3.10 BS03 XE B 3 P120 F121 I202 Y254 T255 I258 P116 F117 I198 Y250 T251 I254 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc B 3.10 BS05 XE B 5 F37 L126 H127 I128 F165 Y186 L188 F33 L122 H123 I124 F161 Y182 L184 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc C 3.10 BS02 XE C 2 Y119 P120 Y197 I201 T255 Y115 P116 Y193 I197 T251 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 4zzc C 3.10 BS05 XE C 5 F37 I128 F165 L188 F33 I124 F161 L184 VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF 5a1t A 1.97 BS01 NAI A 1 G11 A13 G14 Q15 I16 L40 D41 I42 A45 R48 V86 A87 S88 M89 L100 I107 I128 G129 N130 L154 L157 H186 S240 P244 G8 A10 G11 Q12 I13 L37 D38 I39 A42 R45 V83 A84 S85 M86 L97 I104 I125 G126 N127 L151 L154 H183 S237 P241 1.1.1.27 26889885 AAHVLITGAAGQIGYILSHWIASGELYGDRQVYLHLLDIPPAMNRLTALTMELEDCAFPHLAGFVATTDPKAAFKDIDCAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSKWAKPSVKVLVIGNPDNTNCEIAMLHAKNLKPENFSSLSMLDQNRAYYEVASKLGVDVKDVHDIIVWGNHGESMVADLTQATFTKEGKTQKVVDVLDHDYVFDTFFKKIGHRAWDILEHRGFTSAASPTKAAIQHMKAWLFGTAPGEVLSMGIPVPEGNPYGIKPGVVFSFPCNVDKEGKIHVVEGFKVNDWLREKLDFTEKDLFHEKEIALNHLAQL 5a1t A 1.97 BS02 OXM A 1 R97 N130 L157 R161 H186 A229 T239 S240 R94 N127 L154 R158 H183 A226 T236 S237 1.1.1.27 26889885 AAHVLITGAAGQIGYILSHWIASGELYGDRQVYLHLLDIPPAMNRLTALTMELEDCAFPHLAGFVATTDPKAAFKDIDCAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSKWAKPSVKVLVIGNPDNTNCEIAMLHAKNLKPENFSSLSMLDQNRAYYEVASKLGVDVKDVHDIIVWGNHGESMVADLTQATFTKEGKTQKVVDVLDHDYVFDTFFKKIGHRAWDILEHRGFTSAASPTKAAIQHMKAWLFGTAPGEVLSMGIPVPEGNPYGIKPGVVFSFPCNVDKEGKIHVVEGFKVNDWLREKLDFTEKDLFHEKEIALNHLAQL 5a4x B 2.20 BS03 ZN B 1 H103 D109 H72 D78 26719420 DLLGLLRIRIKRGVNLAVRDISSSDPYVVVKMGSQKLKTRVINKDVNPEWNEDLTLSVTDSNLTVLLTVYDHDMFSKDDKMGDAEFEIKPYIEALRMQLGGLPSGTIVTTVKPSRRNCLAEESRVTWVDGKLVQDLVLRLRHVECGEVEAQLQWIDLPGSSGL 5a50 B 2.40 BS03 PC B 1 Y58 V60 K67 K69 Y101 D109 Y29 V31 K38 K40 Y72 D80 26719420 MDDLLGLLRIRIKRGVNLAVRDISSSDPYVVVKMGSQKLKTRVINKDVNPEWNEDLTLSVTDSNLTVLLTVYDHDMFSKDDKMGDAEFEIKPYIEALRMQLDGLPSGTIVTTVKPSRRNCLAEESRVTWVDGKLVQDLVLRLRHVECGEVEAQLQWIDLPGSSGL 5a50 B 2.40 BS05 PC B 2 Y58 K69 T70 R71 V72 H103 D109 Y29 K40 T41 R42 V43 H74 D80 26719420 MDDLLGLLRIRIKRGVNLAVRDISSSDPYVVVKMGSQKLKTRVINKDVNPEWNEDLTLSVTDSNLTVLLTVYDHDMFSKDDKMGDAEFEIKPYIEALRMQLDGLPSGTIVTTVKPSRRNCLAEESRVTWVDGKLVQDLVLRLRHVECGEVEAQLQWIDLPGSSGL 5a51 B 1.60 BS03 SEP B 1 Y58 K67 K69 Y101 K108 D109 Y29 K38 K40 Y72 K79 D80 26719420 MDDLLGLLRIRIKRGVNLAVRDISSSDPYVVVKMGKQKLKTRVINKDVNPEWNEDLTLSVTDSNLTVLLTVYDHDMFSKDDKMGDAEFEIKPYIEALRMQLDGLPSGTIVTTVKPSRRNCLAEESRVTWVDGKLVQDLVLRLRHVECGEVEAQLQWIDLPGSKGL 5a52 A 1.65 BS01 CA A 1 D22 D27 D73 Y74 D18 D23 D69 Y70 26719420 VGLLRIHVKRGVNLAIRDISSSDPYIVVHCGKQKLKTRVVKHSVNPEWNDDLTLSVTDPNLPIKLTVYDYDLLSADDKMGEAEFHIGPFIEAIKFAHQLGPGLPNGTIIKKIEPSRKNCLSESSHIVLGKIVQNMFLRLQHVECGEVELQLEWI 5acf A 1.80 BS01 CU A 1 H1 H78 Y164 H1 H78 Y164 HTLVWGVWVNGVDQGDGRNIYIRSPPNNNPVKNLTSPDMTCNVDNRVVPKSVPVNAGDTLTFEWYHNTRDDDIIASSHHGPIAVYIAPAASNGQGNVWVKLFEDAYNVTNSTWAVDRLITAHGQHSVVVPHVAPGDYLFRAEIIALHEADSLYSQNPIRGAQFYISCAQITINSSDDSTPLPAGVPFPGAYTDSTPGIQFNIYTTPATSYVAPPPSVWSGALGGSIAQVGDASLE 5acf A 1.80 BS02 BGC A 1 H1 N28 H66 N67 H1 N28 H66 N67 HTLVWGVWVNGVDQGDGRNIYIRSPPNNNPVKNLTSPDMTCNVDNRVVPKSVPVNAGDTLTFEWYHNTRDDDIIASSHHGPIAVYIAPAASNGQGNVWVKLFEDAYNVTNSTWAVDRLITAHGQHSVVVPHVAPGDYLFRAEIIALHEADSLYSQNPIRGAQFYISCAQITINSSDDSTPLPAGVPFPGAYTDSTPGIQFNIYTTPATSYVAPPPSVWSGALGGSIAQVGDASLE 5acf A 1.80 BS03 BGC A 2 H1 H66 H1 H66 HTLVWGVWVNGVDQGDGRNIYIRSPPNNNPVKNLTSPDMTCNVDNRVVPKSVPVNAGDTLTFEWYHNTRDDDIIASSHHGPIAVYIAPAASNGQGNVWVKLFEDAYNVTNSTWAVDRLITAHGQHSVVVPHVAPGDYLFRAEIIALHEADSLYSQNPIRGAQFYISCAQITINSSDDSTPLPAGVPFPGAYTDSTPGIQFNIYTTPATSYVAPPPSVWSGALGGSIAQVGDASLE 5acf A 1.80 BS04 BGC A 3 S77 H78 S77 H78 HTLVWGVWVNGVDQGDGRNIYIRSPPNNNPVKNLTSPDMTCNVDNRVVPKSVPVNAGDTLTFEWYHNTRDDDIIASSHHGPIAVYIAPAASNGQGNVWVKLFEDAYNVTNSTWAVDRLITAHGQHSVVVPHVAPGDYLFRAEIIALHEADSLYSQNPIRGAQFYISCAQITINSSDDSTPLPAGVPFPGAYTDSTPGIQFNIYTTPATSYVAPPPSVWSGALGGSIAQVGDASLE 5ach A 1.28 BS01 CU A 1 T1 H78 I164 T1 H78 I164 TLVWGVWVNGVDQGDGRNIYIRSPPNNNPVKNLTSPDMTCNVDNRVVPKSVPVNAGDTLTFEWYHNTRDDDIIASSHHGPIAVYIAPAASNGQGNVWVKLFEDAYNVTNSTWAVDRLITAHGQHSVVVPHVAPGDYLFRAEIIALHEADSLYSQNPIRGAQFYISCAQITINSSDDSTPLPAGVPFPGAYTDSTPGIQFNIYTTPATSYVAPPPSVWSGALGGSIAQVGDASLE 5aci A 1.75 BS03 BGC A 2 H1 H66 H78 H1 H66 H78 HTLVWGVWVNGVDQGDGRNIYIRSPPNNNPVKNLTSPDMTCNVDNRVVPKSVPVNAGDTLTFEWYHNTRDDDIIASSHHGPIAVYIAPAASNGQGNVWVKLFEDAYNVTNSTWAVDRLITAHGQHSVVVPHVAPGDYLFRAEIIALHEADSLYSQNPIRGAQFYISCAQITINSSDDSTPLPAGVPFPGAYTDSTPGIQFNIYTTPATSYVAPPPSVWSGALGGSIAQVGDASLE 5aci A 1.75 BS04 BGC A 3 S77 H78 H147 E148 S77 H78 H147 E148 HTLVWGVWVNGVDQGDGRNIYIRSPPNNNPVKNLTSPDMTCNVDNRVVPKSVPVNAGDTLTFEWYHNTRDDDIIASSHHGPIAVYIAPAASNGQGNVWVKLFEDAYNVTNSTWAVDRLITAHGQHSVVVPHVAPGDYLFRAEIIALHEADSLYSQNPIRGAQFYISCAQITINSSDDSTPLPAGVPFPGAYTDSTPGIQFNIYTTPATSYVAPPPSVWSGALGGSIAQVGDASLE 5aci A 1.75 BS05 BGC A 4 E148 R159 Y203 E148 R159 Y203 HTLVWGVWVNGVDQGDGRNIYIRSPPNNNPVKNLTSPDMTCNVDNRVVPKSVPVNAGDTLTFEWYHNTRDDDIIASSHHGPIAVYIAPAASNGQGNVWVKLFEDAYNVTNSTWAVDRLITAHGQHSVVVPHVAPGDYLFRAEIIALHEADSLYSQNPIRGAQFYISCAQITINSSDDSTPLPAGVPFPGAYTDSTPGIQFNIYTTPATSYVAPPPSVWSGALGGSIAQVGDASLE 5acj A 1.70 BS03 BGC A 2 H1 H66 A75 H78 H1 H66 A75 H78 HTLVWGVWVNGVDQGDGRNIYIRSPPNNNPVKNLTSPDMTCNVDNRVVPKSVPVNAGDTLTFEWYHNTRDDDIIASSHHGPIAVYIAPAASNGQGNVWVKLFEDAYNVTNSTWAVDRLITAHGQHSVVVPHVAPGDYLFRAEIIALHEADSLYSQNPIRGAQFYISCAQITINSSDDSTPLPAGVPFPGAYTDSTPGIQFNIYTTPATSYVAPPPSVWSGALGGSIAQVGDASLE 5ag1 A 1.85 BS01 N7H A 1 E162 F166 L167 D168 G169 I170 A171 L219 Q221 V253 R255 H304 I305 T308 R309 R311 R332 L357 F359 F370 I397 I398 E160 F164 L165 D166 G167 I168 A169 L217 Q219 V251 R253 H302 I303 T306 R307 R309 R330 L355 F357 F368 I395 I396 1.11.1.19 SLNTDDIQGDILVGMHKQKQLFYFFAINDPATFKTHLASDIAPVVASVTQLSNVATQPLVALNIAFSNTGLLALGVTDNLGDSLFANGQAKDATSFKESTSSWVPQFAGTGIHGVIILASDTTDLIDQQVASIESTFGSSISKLYSLSASIRPGNEAGHEMFGFLDGIAQPAINGFNTPLPGQNIVDAGVIITGATNDPITRPSWAVGGSFLAFRQLEQLVPEFNKYLLDNAPAGSGSLQARADLLGARMVGRWKSGAPIDLTPTADDPALGADAQRNNNFTYSHAGFDLGSDQSHCPFSAHIRKTRPRADLGGSLTPPNLSAGANSIMRSGIPYGPEVTSAESASNTTTQERGLAFVAYQAQLSQGFHFLQQTWADNANFPPGKTPATVGLDPIIGQNNGQPRVVNGLLPSNSSASLSIPQFVVSHGGEYFFSPPISAIGGRLSA 5agr A 1.30 BS01 A52 A 1 F335 T336 T337 R338 Y430 V431 L432 Y435 I440 M441 V443 H446 D447 R449 D450 F16 T17 T18 R19 Y107 V108 L109 Y112 I117 M118 V120 H123 D124 R126 D127 6.1.1.4 GAVALFSARAVDIEVFTTRPDTLFGATYLVLAPEHDLVDELVAASWPAGVNPLWTYGGGTPGEAIAAYRRAIAAKSDLERQKTGVFLGSYAINPANGEPVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFARAFGLPIVEVIAGGNISESAYTGDGILVNSDYLNGMSVPAAKRAIVDRLESAGRGRARI 5ah3 A 2.40 BS01 DMU A 1 R143 L144 G145 P146 V149 E449 P450 R140 L141 G142 P143 V146 E442 P443 QFTGTGTGGDVFKVDLNEQFDRADMVWIGTASVLVWIMIPGVGLLYSGISRKKHALSLMWAALMAACVAAFQWFWWGYSLVFAHNGSVFLGTLQNFCLKDVLGAPSIVKTVPDILFCLYQGMFAAVTAILMAGAGCERARLGPMMVFLFIWLTVVYCPIAYWTWGGNGWLVSLGALDFAGGGPVHENSGFAALAYSLWLGKRHDPVAKGKVPKYKPHSVSSIVMGTIFLWFGWYGFNGGSTGNSSMRSWYACVNTNLAAATGGLTWMLVDWFRTGGKWSTVGLCMGAIAGLVGITPAAGYVPVYTSVIFGIVPAIICNFAVDLKDLLQIDDGMDVWALHGVGGFVGNFMTGLFAADYVAMIDGTEIDGGWMNHHWKQLGYQLAGSCAVAAWSFTVTSIILLAMDRIPFLRIRLHEDGTDLAQIGEYAYYADDDPETNPYVLEPIDDT 5ah3 A 2.40 BS02 DMU A 2 W373 M374 H376 W378 W370 M371 H373 W375 QFTGTGTGGDVFKVDLNEQFDRADMVWIGTASVLVWIMIPGVGLLYSGISRKKHALSLMWAALMAACVAAFQWFWWGYSLVFAHNGSVFLGTLQNFCLKDVLGAPSIVKTVPDILFCLYQGMFAAVTAILMAGAGCERARLGPMMVFLFIWLTVVYCPIAYWTWGGNGWLVSLGALDFAGGGPVHENSGFAALAYSLWLGKRHDPVAKGKVPKYKPHSVSSIVMGTIFLWFGWYGFNGGSTGNSSMRSWYACVNTNLAAATGGLTWMLVDWFRTGGKWSTVGLCMGAIAGLVGITPAAGYVPVYTSVIFGIVPAIICNFAVDLKDLLQIDDGMDVWALHGVGGFVGNFMTGLFAADYVAMIDGTEIDGGWMNHHWKQLGYQLAGSCAVAAWSFTVTSIILLAMDRIPFLRIRLHEDGTDLAQIGEYAYYADDDPETNPYVLEPIDDT 5ah3 A 2.40 BS03 DMU A 3 F92 W172 A390 F89 W169 A387 QFTGTGTGGDVFKVDLNEQFDRADMVWIGTASVLVWIMIPGVGLLYSGISRKKHALSLMWAALMAACVAAFQWFWWGYSLVFAHNGSVFLGTLQNFCLKDVLGAPSIVKTVPDILFCLYQGMFAAVTAILMAGAGCERARLGPMMVFLFIWLTVVYCPIAYWTWGGNGWLVSLGALDFAGGGPVHENSGFAALAYSLWLGKRHDPVAKGKVPKYKPHSVSSIVMGTIFLWFGWYGFNGGSTGNSSMRSWYACVNTNLAAATGGLTWMLVDWFRTGGKWSTVGLCMGAIAGLVGITPAAGYVPVYTSVIFGIVPAIICNFAVDLKDLLQIDDGMDVWALHGVGGFVGNFMTGLFAADYVAMIDGTEIDGGWMNHHWKQLGYQLAGSCAVAAWSFTVTSIILLAMDRIPFLRIRLHEDGTDLAQIGEYAYYADDDPETNPYVLEPIDDT 5ahi A 2.00 BS01 GUO A 1 G81 V82 R83 V100 G102 S103 A127 G73 V74 R75 V92 G94 S95 A119 5.3.1.16 MIIPALNLIDGTVVRLRDYGNDPLPRLQDYAAQGAGVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRTEEDVAALLKAGVARVVIGSTAVKSPDVVKGWFERFGAQALVLALDVRIDEHGTKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIRDGAGSVSLYEEVCARYPQIAFQSSGGIGDIDDIAALRGTGVRGVIVGRALLEGKFTVKEAIQCWQN 5ahk A 1.55 BS01 TPP A 1 V394 G395 N396 N397 G420 M422 G445 D446 G447 G448 N473 S475 L476 G477 M478 V479 V384 G385 N386 N387 G410 M412 G435 D436 G437 G438 N463 S465 L466 G467 M468 V469 2.2.1.6 MKASDAVAKILADNNVLYGFELIGGMITHLVDSINLLGKTKLVSMHHEQGAAFAASAVSRVTHHKTLGLALATSGPGATNLITGIADCWLDSHPCIFLTGQVNTHELKGKRDIRQQGFQELDSVALVTSITKYAYQIKSADELVPCLRKAIQIAKEGRPGPVLLDIPMDIQRADIDEALLNNPSIAMSDLDFIINKLQNAKKPLLLIGGGAVNSSGFQKWLEQIELRGIPYVASLKGAEKIKASDLYLGMLGAYGTRAANHAVQNCDLLLVLGSRMDVRQTGAQPEDFARNAEIIQIDLQEGQLNNRVIADFSYQIELSEYFSRFSPLQIPVNNDWSVWTALLKEKFRVTFIDEYTTWNLSPFGLFTQLNKLTERVALDYILDVGNNQMWAAHTLRLNAQQAMHHSGGLGSMGFAIPAAIGACYAGKKPIIVITGDGGAQLNIQELDIIARDKLPILTIVMNNHSLGMVRGFQEMYFEGRNSSTYWNGYTSQFKKIGEAYRVESKTIISMQAFSSALESFLESPRPLLLEVSMSDARECRPRLEYGRAIDQQSPR 5ahk A 1.55 BS02 FAD A 1 R158 G218 G219 G220 S224 S244 L245 K246 M260 L261 A263 Y264 G283 S284 R285 D287 R289 Q290 D308 L309 Q310 Q313 I326 E327 L328 Q398 M399 S416 G417 G418 G420 M478 R158 G208 G209 G210 S214 S234 L235 K236 M250 L251 A253 Y254 G273 S274 R275 D277 R279 Q280 D298 L299 Q300 Q303 I316 E317 L318 Q388 M389 S406 G407 G408 G410 M468 2.2.1.6 MKASDAVAKILADNNVLYGFELIGGMITHLVDSINLLGKTKLVSMHHEQGAAFAASAVSRVTHHKTLGLALATSGPGATNLITGIADCWLDSHPCIFLTGQVNTHELKGKRDIRQQGFQELDSVALVTSITKYAYQIKSADELVPCLRKAIQIAKEGRPGPVLLDIPMDIQRADIDEALLNNPSIAMSDLDFIINKLQNAKKPLLLIGGGAVNSSGFQKWLEQIELRGIPYVASLKGAEKIKASDLYLGMLGAYGTRAANHAVQNCDLLLVLGSRMDVRQTGAQPEDFARNAEIIQIDLQEGQLNNRVIADFSYQIELSEYFSRFSPLQIPVNNDWSVWTALLKEKFRVTFIDEYTTWNLSPFGLFTQLNKLTERVALDYILDVGNNQMWAAHTLRLNAQQAMHHSGGLGSMGFAIPAAIGACYAGKKPIIVITGDGGAQLNIQELDIIARDKLPILTIVMNNHSLGMVRGFQEMYFEGRNSSTYWNGYTSQFKKIGEAYRVESKTIISMQAFSSALESFLESPRPLLLEVSMSDARECRPRLEYGRAIDQQSPR 5ahk A 1.55 BS03 MG A 1 D446 N473 S475 D436 N463 S465 2.2.1.6 MKASDAVAKILADNNVLYGFELIGGMITHLVDSINLLGKTKLVSMHHEQGAAFAASAVSRVTHHKTLGLALATSGPGATNLITGIADCWLDSHPCIFLTGQVNTHELKGKRDIRQQGFQELDSVALVTSITKYAYQIKSADELVPCLRKAIQIAKEGRPGPVLLDIPMDIQRADIDEALLNNPSIAMSDLDFIINKLQNAKKPLLLIGGGAVNSSGFQKWLEQIELRGIPYVASLKGAEKIKASDLYLGMLGAYGTRAANHAVQNCDLLLVLGSRMDVRQTGAQPEDFARNAEIIQIDLQEGQLNNRVIADFSYQIELSEYFSRFSPLQIPVNNDWSVWTALLKEKFRVTFIDEYTTWNLSPFGLFTQLNKLTERVALDYILDVGNNQMWAAHTLRLNAQQAMHHSGGLGSMGFAIPAAIGACYAGKKPIIVITGDGGAQLNIQELDIIARDKLPILTIVMNNHSLGMVRGFQEMYFEGRNSSTYWNGYTSQFKKIGEAYRVESKTIISMQAFSSALESFLESPRPLLLEVSMSDARECRPRLEYGRAIDQQSPR 5ahk A 1.55 BS04 TPP B 1 L22 I23 E48 P76 N80 Q119 L22 I23 E48 P76 N80 Q119 2.2.1.6 MKASDAVAKILADNNVLYGFELIGGMITHLVDSINLLGKTKLVSMHHEQGAAFAASAVSRVTHHKTLGLALATSGPGATNLITGIADCWLDSHPCIFLTGQVNTHELKGKRDIRQQGFQELDSVALVTSITKYAYQIKSADELVPCLRKAIQIAKEGRPGPVLLDIPMDIQRADIDEALLNNPSIAMSDLDFIINKLQNAKKPLLLIGGGAVNSSGFQKWLEQIELRGIPYVASLKGAEKIKASDLYLGMLGAYGTRAANHAVQNCDLLLVLGSRMDVRQTGAQPEDFARNAEIIQIDLQEGQLNNRVIADFSYQIELSEYFSRFSPLQIPVNNDWSVWTALLKEKFRVTFIDEYTTWNLSPFGLFTQLNKLTERVALDYILDVGNNQMWAAHTLRLNAQQAMHHSGGLGSMGFAIPAAIGACYAGKKPIIVITGDGGAQLNIQELDIIARDKLPILTIVMNNHSLGMVRGFQEMYFEGRNSSTYWNGYTSQFKKIGEAYRVESKTIISMQAFSSALESFLESPRPLLLEVSMSDARECRPRLEYGRAIDQQSPR 5ai2 A 1.75 BS01 D8U A 1 K6 E47 K7 E48 MAKWVCKICGYIYDEDAGDPDNGISPGTKFEELPDDWVCPICGAPKSEFEKLED 5aip A 2.30 BS01 4HP B 1 S9 N11 S9 N11 MPTQSKHASINIGLIQAREALMTQFRPILNQANITDQQWRIIRLLAENGTLDFQDLANQACILRPSLTGILTRLEKAGLVVRLKPSNDQRRVFLKLTAEGEKLYEEIGEEVDERYDAIEEVLGREKMLLLKDLLAELAKIE 5aip B 2.30 BS01 4HP B 1 L21 M22 F25 L29 D36 W39 R43 V111 Y115 L13 M14 F17 L21 D28 W31 R35 V98 Y102 SINIGLIQAREALMTQFRPILNQANITDQQWRIIRLLAENGTLDFQDLANQACILRPSLTGILTRLEKAGLVVRLKPRVFLKLTAEGEKLYEEIGEEVDERYDAIEEVLGREKMLLLKDLLAELAKIEDALN 5ajb A 1.80 BS04 FUC C 1 P14 W31 W36 P13 W30 W35 SVQTAATSWGTVPSIRVYTANNGKITERCWDGKGWYTGAFNEPGDNVSVTSWLVGSAIHIRVYASTGTTTTEWCWDGNGWTKGAYTATN 5ajb B 1.80 BS01 FUC A 3 W31 W36 W30 W35 SVQTAATSWGTVPSIRVYTANNGKITERCWDGKGWYTGAFNEPGDNVSVTSWLVGSAIHIRVYASTGTTTTEWCWDGNGWTKGAYTATN 5ajb B 1.80 BS03 GAL B 1 W10 S15 R17 D32 S57 A58 I59 W9 S14 R16 D31 S56 A57 I58 SVQTAATSWGTVPSIRVYTANNGKITERCWDGKGWYTGAFNEPGDNVSVTSWLVGSAIHIRVYASTGTTTTEWCWDGNGWTKGAYTATN 5ajb B 1.80 BS04 FUC B 2 R62 E73 C75 G84 A85 Y86 R61 E72 C74 G83 A84 Y85 SVQTAATSWGTVPSIRVYTANNGKITERCWDGKGWYTGAFNEPGDNVSVTSWLVGSAIHIRVYASTGTTTTEWCWDGNGWTKGAYTATN 5ajb C 1.80 BS02 FUC C 2 R17 E28 C30 Y37 G39 A40 F41 I61 W76 W81 R17 E28 C30 Y37 G39 A40 F41 I61 W76 W81 SSVQTAATSWGTVPSIRVYTANNGKITERCWDGKGWYTGAFNEPGDNVSVTSWLVGSAIHIRVYASTGTTTTEWCWDGNGWTKGAYTAT 5ajc A 1.70 BS02 FUL A 1 W53 R62 E73 A85 Y86 W53 R62 E73 A85 Y86 SSVQTAATSWGTVPSIRVYTANNGKITERCWDGKGWYTGAFNEPGDNVSVTSWLVGSAIHIRVYASTGTTTTEWCWDGNGWTKGAYTAT 5ajc B 1.70 BS01 FUL A 1 I16 W31 W36 I16 W31 W36 SSVQTAATSWGTVPSIRVYTANNGKITERCWDGKGWYTGAFNEPGDNVSVTSWLVGSAIHIRVYASTGTTTTEWCWDGNGWTKGAYTAT 5ajc C 1.70 BS04 SIA C 1 W76 N79 G80 W81 W76 N79 G80 W81 SSVQTAATSWGTVPSIRVYTANNGKITERCWDGKGWYTGAFNEPGDNVSVTSWLVGSAIHIRVYASTGTTTTEWCWDGNGWTKGAYTAT 5ans A 1.60 BS01 RX8 A 1 Y7 T8 L9 K23 N33 G34 G36 G37 F72 M81 W117 D119 D120 Y6 T7 L8 K22 N32 G33 G35 G36 F71 M80 W116 D118 D119 3.6.1.55 26878898 GASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV 5ant A 2.00 BS01 RJE A 1 L9 L11 F27 N33 G34 G36 G37 F72 M81 V83 W117 D119 D120 L8 L10 F26 N32 G33 G35 G36 F71 M80 V82 W116 D118 D119 3.6.1.55,3.6.1.56 26878898 GASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV 5ant B 2.00 BS01 RJE B 1 T8 L9 L11 N33 G34 G36 G37 F72 M81 V83 W117 D119 D120 T7 L8 L10 N32 G33 G35 G36 F71 M80 V82 W116 D118 D119 3.6.1.55,3.6.1.56 26878898 GASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV 5ant C 2.00 BS01 RJE C 1 Y7 T8 L9 L11 N33 G34 G36 G37 F72 M81 V83 W117 D119 D120 F124 Y4 T5 L6 L8 N30 G31 G33 G34 F69 M78 V80 W114 D116 D117 F121 3.6.1.55,3.6.1.56 26878898 SRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV 5anv A 1.16 BS01 RGJ A 1 Y7 L9 F27 N33 G34 G36 G37 F72 F74 M81 W117 D119 D120 W123 F124 F139 Y5 L7 F25 N31 G32 G34 G35 F70 F72 M79 W114 D116 D117 W120 F121 F136 3.6.1.55,3.6.1.56 26878898 ASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV 5anw A 1.37 BS01 9CQ A 1 T8 L9 F27 N33 G34 F35 G36 G37 F72 F74 M81 W117 D119 D120 F139 T6 L7 F25 N31 G32 F33 G34 G35 F70 F72 M79 W115 D117 D118 F137 3.6.1.55,3.6.1.56 26878898 ASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV 5aov A 1.40 BS01 NAP A 1 V76 T104 G157 F158 G159 R160 I161 Y179 S180 R181 T182 K184 A211 V212 P213 E217 T218 I239 A240 R241 D265 V266 H288 G290 S291 V76 T104 G157 F158 G159 R160 I161 Y179 S180 R181 T182 K184 A211 V212 P213 E217 T218 I239 A240 R241 D265 V266 H288 G290 S291 1.1.1.26,1.1.1.81,1.1.1.79 26865263 MKPKVFITRAIPENGINMLEEEFEVEVWEEEREIPREKLLEKVKDVDALVTMLSERIDQEVFENAPRLRIVANYAVGYDNIDVEEATRRGIYVTNTPDVLTNATADHAFALLLATARHVVKGDKFVRSGEWKRKGIAWHPKWFLGYELYGKTIGIVGFGRIGQAIARRAKGFNMRILYYSRTRKSQAEKELGAEYRPLEEVLKESDFVILAVPLTKETMYMINEERLKLMKPTAILVNIARGKVVDTKALIKALKEGWIAGAGLDVFEEEPYYNEELFSLDNVVLTPHIGSATFEAREAMAELVARNLIAFKRGEIPPTLVNKEVIKIRKPGFN 5aov A 1.40 BS02 GLV A 1 L53 A75 V76 G77 L100 R241 H288 L53 A75 V76 G77 L100 R241 H288 1.1.1.26,1.1.1.81,1.1.1.79 26865263 MKPKVFITRAIPENGINMLEEEFEVEVWEEEREIPREKLLEKVKDVDALVTMLSERIDQEVFENAPRLRIVANYAVGYDNIDVEEATRRGIYVTNTPDVLTNATADHAFALLLATARHVVKGDKFVRSGEWKRKGIAWHPKWFLGYELYGKTIGIVGFGRIGQAIARRAKGFNMRILYYSRTRKSQAEKELGAEYRPLEEVLKESDFVILAVPLTKETMYMINEERLKLMKPTAILVNIARGKVVDTKALIKALKEGWIAGAGLDVFEEEPYYNEELFSLDNVVLTPHIGSATFEAREAMAELVARNLIAFKRGEIPPTLVNKEVIKIRKPGFN 5aov A 1.40 BS03 GLV A 2 M52 L53 Y74 A75 M52 L53 Y74 A75 1.1.1.26,1.1.1.81,1.1.1.79 26865263 MKPKVFITRAIPENGINMLEEEFEVEVWEEEREIPREKLLEKVKDVDALVTMLSERIDQEVFENAPRLRIVANYAVGYDNIDVEEATRRGIYVTNTPDVLTNATADHAFALLLATARHVVKGDKFVRSGEWKRKGIAWHPKWFLGYELYGKTIGIVGFGRIGQAIARRAKGFNMRILYYSRTRKSQAEKELGAEYRPLEEVLKESDFVILAVPLTKETMYMINEERLKLMKPTAILVNIARGKVVDTKALIKALKEGWIAGAGLDVFEEEPYYNEELFSLDNVVLTPHIGSATFEAREAMAELVARNLIAFKRGEIPPTLVNKEVIKIRKPGFN 5aow A 2.00 BS01 NAP A 1 V76 G77 T104 G157 F158 G159 R160 I161 A180 R181 S182 K184 A211 V212 P213 E217 T218 V239 A240 R241 D265 V266 H288 G290 V76 G77 T104 G157 F158 G159 R160 I161 A180 R181 S182 K184 A211 V212 P213 E217 T218 V239 A240 R241 D265 V266 H288 G290 1.1.1.81,1.1.1.79 26865263 MKPKVLITRAIPENGIELLREHFEVEVWEHEHEIPREVLLEKVKDVDALVTMLSEKIDREVFDAAPRLRIVANYAVGYDNIDIEEATKRGIYVTNTPDVLTDATADLAWALLLAAARHVVKGDKFVRSGEWKRRGIAWHPKMFLGYDVYGKTIGIVGFGRIGQAIAKRAKGFGMRILYTARSRKPEAEKELGAEFKPLEELLRESDFVVLAVPLTKETYHMINEERLRLMKPTAVLVNVARGKVVDTKALIRALKEGWIAAAGLDVFEEEPYYDEELFALDNVVLTPHIGSATFGAREGMAELVAKNLIAFKNGEVPPTLVNREVLKVRRPGF 5aow A 2.00 BS02 DGY A 1 L53 A75 V76 G77 L100 R241 H288 L53 A75 V76 G77 L100 R241 H288 1.1.1.81,1.1.1.79 26865263 MKPKVLITRAIPENGIELLREHFEVEVWEHEHEIPREVLLEKVKDVDALVTMLSEKIDREVFDAAPRLRIVANYAVGYDNIDIEEATKRGIYVTNTPDVLTDATADLAWALLLAAARHVVKGDKFVRSGEWKRRGIAWHPKMFLGYDVYGKTIGIVGFGRIGQAIAKRAKGFGMRILYTARSRKPEAEKELGAEFKPLEELLRESDFVVLAVPLTKETYHMINEERLRLMKPTAVLVNVARGKVVDTKALIRALKEGWIAAAGLDVFEEEPYYDEELFALDNVVLTPHIGSATFGAREGMAELVAKNLIAFKNGEVPPTLVNREVLKVRRPGF 5ave A 1.80 BS01 SER A 1 W141 W147 R152 W154 Y170 D172 S173 F199 D201 W85 W91 R96 W98 Y114 D116 S117 F143 D145 26878914 SVRDEIRSMVSDSVDEIVDGVSKTTAEVINGRKSIAQYATSLIESNPEPDNVRTIISQPLIKNTFLLVGFGLEKDGSNINNDPSWNPGPTWDPRVRPWYKDAKNAGKLVITAPYADSASGEILVSVATPVKDSATGQFLGSIFYDVSLAELAELVNEVKLFDAGYVFIVSEDGTTIAHPKKEFNGKPMSEFLGESKINVDTHQVIINGKPYAVSFSDVEGEDWYVGVVIDEEIAYAALDELRRSTLIHHHHH 5axi A 2.50 BS01 CA A 1 D221 T223 N225 Y227 E232 D184 T186 N188 Y190 E195 6.3.2.- 26874193 QAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLT 5axi B 2.50 BS01 III E 1 Y266 K270 R286 S288 C289 T290 Q308 T309 I310 Y227 K231 R247 S249 C250 T251 Q269 T270 I271 6.3.2.- 26874193 AADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDL 5ayg A 2.60 BS01 4LQ A 1 C320 H323 L324 A327 M365 A368 V376 F377 F378 F388 I400 F401 C57 H60 L61 A64 M102 A105 V113 F114 F115 F125 I137 F138 26819660 YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV 5ayg B 2.60 BS01 4LQ B 1 C320 H323 L324 A327 M365 A368 V376 F377 F378 F388 L396 I397 I400 F401 C57 H60 L61 A64 M102 A105 V113 F114 F115 F125 L133 I134 I137 F138 26819660 YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVER 5b24 A 3.60 BS01 NUC I 1 R40 R42 P43 T45 R63 R72 R83 F84 Q85 R116 V117 T118 M120 R3 R5 P6 T8 R26 R35 R46 F47 Q48 R79 V80 T81 M83 26837048 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 5b24 C 3.60 BS01 NUC I 1 R11 A12 A14 K15 T16 R17 R20 G28 R32 R42 K74 R77 R1 A2 A4 K5 T6 R7 R10 G18 R22 R32 K64 R67 26837048 RAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 5b24 E 3.60 BS01 NUC I 1 H39 R40 Y41 P43 G44 V46 R49 K56 R63 K64 L65 R69 R83 H3 R4 Y5 P7 G8 V10 R13 K20 R27 K28 L29 R33 R47 26837048 KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 5b24 E 3.60 BS02 NUC J 1 H39 R40 R42 T45 R63 R72 R83 F84 Q85 S86 R116 V117 T118 M120 H3 R4 R6 T9 R27 R36 R47 F48 Q49 S50 R80 V81 T82 M84 26837048 KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 5b2o A 1.70 BS01 NUC B 1 Y48 T49 L51 M52 R55 T56 R58 R59 H60 Q61 R62 R63 I65 R67 Q69 K72 R73 Q92 Q93 S96 F97 N100 R101 R102 G103 F104 S307 G308 R310 Q329 E330 G331 Y332 E364 L365 R369 F372 N373 D374 K375 H377 A378 H394 E399 R401 L450 D451 N452 N453 N454 R455 K456 P457 K459 S506 S507 K508 Y512 Q522 I523 S525 G526 Q527 R622 Y632 R633 H639 K640 Y641 N642 N643 R646 K660 P661 R662 Q663 K664 R665 Y666 D671 L714 Q717 K718 Q798 Q801 I802 R807 A811 N812 T813 R849 A852 P854 V858 D859 G860 K871 K912 K914 K917 R1047 S1048 N1051 N1084 T1086 L1105 K1109 R1226 K1227 F1233 T1235 H1236 R1237 Q1238 M1239 T1240 I1244 Y1245 A1246 A1322 Y1329 N1331 Q1335 E1369 R1370 K1372 P1397 E1401 R1404 F1425 N1426 V1427 K1435 K1436 V1437 R1438 K1439 D1440 S1442 L1443 P1444 R1456 K1457 T1458 W1459 I1464 Q1466 S1499 F1500 S1502 K1503 N1504 I1505 Y48 T49 L51 M52 R55 T56 R58 R59 H60 Q61 R62 R63 I65 R67 Q69 K72 R73 Q92 Q93 S96 F97 N100 R101 R102 G103 F104 S248 G249 R251 Q270 E271 G272 Y273 E305 L306 R310 F313 N314 D315 K316 H318 A319 H335 E340 R342 L391 D392 N393 N394 N395 R396 K397 P398 K400 S447 S448 K449 Y453 Q463 I464 S466 G467 Q468 R554 Y564 R565 H571 K572 Y573 N574 N575 R578 K592 P593 R594 Q595 K596 R597 Y598 D603 L646 Q649 K650 Q723 Q726 I727 R732 A736 N737 T738 R763 A766 P768 V772 D773 G774 K785 K826 K828 K831 R891 S892 N895 N928 T930 L949 K953 R1059 K1060 F1066 T1068 H1069 R1070 Q1071 M1072 T1073 I1077 Y1078 A1079 A1155 Y1162 N1164 Q1168 E1202 R1203 K1205 P1230 E1234 R1237 F1258 N1259 V1260 K1268 K1269 V1270 R1271 K1272 D1273 S1275 L1276 P1277 R1289 K1290 T1291 W1292 I1297 Q1299 S1332 F1333 S1335 K1336 N1337 I1338 3.1.-.- 26875867 MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLMQKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNIQEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDNEFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYRSERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSRPKVRVKLDYVIDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMKLAGI 5b2o A 1.70 BS02 NUC C 1 F106 K405 Y449 L450 D451 N452 N453 V545 K546 R622 Q677 R721 G722 K789 Y794 G809 N810 M825 S844 A845 Q848 R849 T855 R856 I857 V858 R920 R1047 R1241 D1242 G1243 E1449 D1472 R1474 K1583 R1585 N1608 K1609 F106 K346 Y390 L391 D392 N393 N394 V486 K487 R554 Q609 R653 G654 K714 Y719 G734 N735 M750 S758 A759 Q762 R763 T769 R770 I771 V772 R834 R891 R1074 D1075 G1076 E1282 D1305 R1307 K1416 R1418 N1441 K1442 3.1.-.- 26875867 MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLMQKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNIQEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDNEFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYRSERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSRPKVRVKLDYVIDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMKLAGI 5b2o A 1.70 BS03 NUC D 1 N1448 K1451 D1470 S1473 R1474 K1479 W1507 P1509 N1553 N1554 S1555 R1556 K1558 R1585 Y1586 E1603 N1281 K1284 D1303 S1306 R1307 K1312 W1340 P1342 N1386 N1387 S1388 R1389 K1391 R1418 Y1419 E1436 3.1.-.- 26875867 MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLMQKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNIQEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDNEFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYRSERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSRPKVRVKLDYVIDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMKLAGI 5b2o A 1.70 BS04 ZN A 1 C460 C657 C814 C817 C401 C589 C739 C742 3.1.-.- 26875867 MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLMQKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNIQEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDNEFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYRSERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSRPKVRVKLDYVIDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMKLAGI 5b2o A 1.70 BS05 CA A 1 D11 E903 H1162 D11 E817 H1006 3.1.-.- 26875867 MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLMQKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNIQEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDNEFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYRSERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSRPKVRVKLDYVIDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMKLAGI 5b2o A 1.70 BS06 CA A 2 K1415 D1417 K1248 D1250 3.1.-.- 26875867 MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLMQKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNIQEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDNEFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYRSERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSRPKVRVKLDYVIDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMKLAGI 5b2o A 1.70 BS07 CA A 3 E1231 N1234 I1497 D1498 S1499 E1064 N1067 I1330 D1331 S1332 3.1.-.- 26875867 MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLMQKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNIQEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDNEFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYRSERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSRPKVRVKLDYVIDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMKLAGI 5b2q A 1.70 BS02 NUC C 1 F106 K405 Y449 L450 D451 N452 N453 V545 K546 R622 Q677 G722 N725 K789 Y794 G809 N810 M825 S844 A845 Q848 R849 T855 R856 V858 R920 R1047 R1241 D1242 G1243 K1385 H1449 D1472 R1474 K1583 N1608 K1609 F106 K346 Y390 L391 D392 N393 N394 V486 K487 R554 Q609 G654 N657 K714 Y719 G734 N735 M750 S758 A759 Q762 R763 T769 R770 V772 R834 R891 R1074 D1075 G1076 K1218 H1282 D1305 R1307 K1416 N1441 K1442 3.1.-.- 26875867 MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLMQKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNIQEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDNEFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYRSRRVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNHGKFLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSAPKVRVKLDYVIDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMKLAGI 5b2q A 1.70 BS03 NUC D 1 K1451 S1473 R1474 K1479 W1507 N1553 N1554 S1555 K1558 R1585 Y1586 E1603 K1284 S1306 R1307 K1312 W1340 N1386 N1387 S1388 K1391 R1418 Y1419 E1436 3.1.-.- 26875867 MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLMQKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNIQEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDNEFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYRSRRVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNHGKFLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSAPKVRVKLDYVIDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMKLAGI 5bpf B 2.28 BS01 ADP B 1 K97 K144 S151 M154 E180 K181 W182 L183 E187 Y210 M259 E270 K97 K144 S148 M151 E176 K177 W178 L179 E183 Y206 M254 E265 6.3.2.4 26894530 MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHSVGMSKVDHASELQKALVEAFQDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKLSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5bpf C 2.28 BS01 ADP C 1 K97 I142 K144 E148 S151 M154 E180 K181 W182 L183 E187 F209 Y210 M259 E270 K97 I142 K144 E148 S151 M154 E180 K181 W182 L183 E187 F209 Y210 M259 E270 6.3.2.4 26894530 MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHEGSSVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKYLSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5bph A 1.70 BS01 AMP A 1 K97 I142 K144 M154 E180 K181 W182 L183 E187 F209 Y210 M259 L269 E270 K97 I142 K144 M154 E180 K181 W182 L183 E187 F209 Y210 M259 L269 E270 6.3.2.4 26894530 MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHEGSSVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKYLSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5brp A 2.05 BS01 PNG A 1 D63 N64 Y66 H106 F148 Y167 D203 V204 E254 D58 N59 Y61 H101 F143 Y162 D198 V199 E249 3.2.1.93 26894535 NPWWKKAVVYQIYPKSFKDTTGNGVGDIRGIIEKLDYIKELACDVIWLTPIYQSPQNDNGYDISDYYSIHEEYGTMADFEELLEEAHKRGIKVIMDLVVNHTSTEHRWFKEAASGKENLYRDFYIWKDMKPNGAPPTNWESKFGGSAWEFHAESGQYYLHLYDVTQADLNWENEAVRKKVYEMMHFWFEKGIDGFQLDVINVISKDQRFPDDDEGDGRRFYTDGPRVHEFLNEMNREVFSKYDSMTVGEMSSTTIADCIRYTNPESRELDMVFNFHHLKADYPNGEKWALADFDFLKLKKILSEWQTEMNKGGGWNALFWCNHDQPRIVSRYGDDGKYRKKSAKMLATAIHMLQGTPYIYQGEELGMTNPKFDDISLYRDVESLNMYRILKEAGKPEAEIIEILKAKSRDNSRTPVQWNGEENAGFTAGTPWIPVPDNYKEINAEEALNDPDSIFYHYKKLNELRKEFDIITTGDYQLILEDDQELYAYLRNGADEKLLVINNFYGKETEFQLPDDIDIEGYDAKVLISNDTDLPESFKRFTVKPYQSIVYHLAK 5brp A 2.05 BS02 MG A 1 D24 T26 N28 V30 D32 D19 T21 N23 V25 D27 3.2.1.93 26894535 NPWWKKAVVYQIYPKSFKDTTGNGVGDIRGIIEKLDYIKELACDVIWLTPIYQSPQNDNGYDISDYYSIHEEYGTMADFEELLEEAHKRGIKVIMDLVVNHTSTEHRWFKEAASGKENLYRDFYIWKDMKPNGAPPTNWESKFGGSAWEFHAESGQYYLHLYDVTQADLNWENEAVRKKVYEMMHFWFEKGIDGFQLDVINVISKDQRFPDDDEGDGRRFYTDGPRVHEFLNEMNREVFSKYDSMTVGEMSSTTIADCIRYTNPESRELDMVFNFHHLKADYPNGEKWALADFDFLKLKKILSEWQTEMNKGGGWNALFWCNHDQPRIVSRYGDDGKYRKKSAKMLATAIHMLQGTPYIYQGEELGMTNPKFDDISLYRDVESLNMYRILKEAGKPEAEIIEILKAKSRDNSRTPVQWNGEENAGFTAGTPWIPVPDNYKEINAEEALNDPDSIFYHYKKLNELRKEFDIITTGDYQLILEDDQELYAYLRNGADEKLLVINNFYGKETEFQLPDDIDIEGYDAKVLISNDTDLPESFKRFTVKPYQSIVYHLAK 5brp B 2.05 BS01 PNG B 1 D63 N64 Y66 H106 F148 Y167 D203 E254 D58 N59 Y61 H101 F143 Y162 D198 E249 3.2.1.93 26894535 NPWWKKAVVYQIYPKSFKDTTGNGVGDIRGIIEKLDYIKELACDVIWLTPIYQSPQNDNGYDISDYYSIHEEYGTMADFEELLEEAHKRGIKVIMDLVVNHTSTEHRWFKEAASGKENLYRDFYIWKDMKPNGAPPTNWESKFGGSAWEFHAESGQYYLHLYDVTQADLNWENEAVRKKVYEMMHFWFEKGIDGFQLDVINVISKDQRFPDDDEGDGRRFYTDGPRVHEFLNEMNREVFSKYDSMTVGEMSSTTIADCIRYTNPESRELDMVFNFHHLKADYPNGEKWALADFDFLKLKKILSEWQTEMNKGGGWNALFWCNHDQPRIVSRYGDDGKYRKKSAKMLATAIHMLQGTPYIYQGEELGMTNPKFDDISLYRDVESLNMYRILKEAGKPEAEIIEILKAKSRDNSRTPVQWNGEENAGFTAGTPWIPVPDNYKEINAEEALNDPDSIFYHYKKLNELRKEFDIITTGDYQLILEDDQELYAYLRNGADEKLLVINNFYGKETEFQLPDDIDIEGYDAKVLISNDTDLPESFKRFTVKPYQSIVYHLAK 5brp C 2.05 BS01 PNG C 1 D63 N64 Y66 H106 F148 Y167 D203 V204 E254 D329 R414 D58 N59 Y61 H101 F143 Y162 D198 V199 E249 D324 R409 3.2.1.93 26894535 NPWWKKAVVYQIYPKSFKDTTGNGVGDIRGIIEKLDYIKELACDVIWLTPIYQSPQNDNGYDISDYYSIHEEYGTMADFEELLEEAHKRGIKVIMDLVVNHTSTEHRWFKEAASGKENLYRDFYIWKDMKPNGAPPTNWESKFGGSAWEFHAESGQYYLHLYDVTQADLNWENEAVRKKVYEMMHFWFEKGIDGFQLDVINVISKDQRFPDDDEGDGRRFYTDGPRVHEFLNEMNREVFSKYDSMTVGEMSSTTIADCIRYTNPESRELDMVFNFHHLKADYPNGEKWALADFDFLKLKKILSEWQTEMNKGGGWNALFWCNHDQPRIVSRYGDDGKYRKKSAKMLATAIHMLQGTPYIYQGEELGMTNPKFDDISLYRDVESLNMYRILKEAGKPEAEIIEILKAKSRDNSRTPVQWNGEENAGFTAGTPWIPVPDNYKEINAEEALNDPDSIFYHYKKLNELRKEFDIITTGDYQLILEDDQELYAYLRNGADEKLLVINNFYGKETEFQLPDDIDIEGYDAKVLISNDTDLPESFKRFTVKPYQSIVYHLAK 5brz A 2.62 BS01 III C 1 Y7 Q62 E63 N66 M67 T73 N77 L81 Y84 Y99 D116 T143 K146 W147 A152 Q155 R156 Y159 R163 R170 Y171 Y7 Q62 E63 N66 M67 T73 N77 L81 Y84 Y99 D116 T143 K146 W147 A152 Q155 R156 Y159 R163 R170 Y171 26758806 GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWP 5brz D 2.62 BS01 III C 1 A98 F101 A97 F100 26758806 AQEVTQIPAALSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLYVRPYQREQTSGRLNASLDKSSGRSTLYIAASQPGDSATYLCAVRPGGAGPFFVVFGKGTKLSVIPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIP 5brz E 2.62 BS01 III C 1 R31 R56 N97 A99 R29 R54 N95 A97 26758806 AGVTQTPRYLIKTRGQQVTLSCSPISGHRSVSWYQQTPGQGLQFLFEYFSETQRNKGNFPGRFSGRQFSNSRSEMNVSTLELGDSALYLCASSFNMATGQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 5bs0 A 2.40 BS01 III C 1 Y7 E63 N66 M67 T73 N77 L81 Y84 I95 Y99 D116 T143 K146 W147 R156 Y159 R163 R170 Y171 Y7 E63 N66 M67 T73 N77 L81 Y84 I95 Y99 D116 T143 K146 W147 R156 Y159 R163 R170 Y171 26758806 GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWP 5bs0 D 2.40 BS01 III C 1 Y32 A98 F101 Y31 A97 F100 26758806 AQEVTQIPAALSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLYVRPYQREQTSGRLNASLDKSSGRSTLYIAASQPGDSATYLCAVRPGGAGPFFVVFGKGTKLSVIPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIP 5bs0 E 2.40 BS01 III C 1 R31 F51 R56 N97 R29 F49 R54 N95 26758806 AGVTQTPRYLIKTRGQQVTLSCSPISGHRSVSWYQQTPGQGLQFLFEYFSETQRNKGNFPGRFSGRQFSNSRSEMNVSTLELGDSALYLCASSFNMATGQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 5bs8 A 2.40 BS01 NUC E 1 R39 K49 V51 H52 H85 H87 S95 R98 I181 R25 K35 V37 H38 H71 H73 S81 R84 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bs8 A 2.40 BS02 NUC F 1 Y28 A126 Y129 I181 A182 V183 G184 M185 R248 K333 Y14 A112 Y115 I167 A168 V169 G170 M171 R234 K319 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bs8 A 2.40 BS03 NUC G 1 R39 H52 H85 H87 S95 R98 G179 I181 R25 H38 H71 H73 S81 R84 G165 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bs8 A 2.40 BS04 NUC H 1 Y28 A126 R128 Y129 I181 A182 V183 G184 M185 R248 Y14 A112 R114 Y115 I167 A168 V169 G170 M171 R234 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bs8 A 2.40 BS05 MFX G 1 R128 Y129 R114 Y115 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bs8 B 2.40 BS01 NUC E 1 E459 D461 G483 K484 R492 D536 I540 E29 D31 G53 K54 R62 D106 I110 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bs8 B 2.40 BS02 NUC F 1 K484 I485 I486 N487 K490 R495 N499 H539 V656 R659 K54 I55 I56 N57 K60 R65 N69 H109 V226 R229 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bs8 B 2.40 BS05 MG B 1 D532 D534 D102 D104 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bs8 B 2.40 BS06 MFX H 1 R482 E501 R52 E71 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bs8 C 2.40 BS02 NUC F 1 R39 K49 V51 H52 H85 H87 S95 R98 G179 I181 R25 K35 V37 H38 H71 H73 S81 R84 G165 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bs8 C 2.40 BS03 NUC G 1 Y28 A126 R128 Y129 I181 A182 G184 M185 R248 S340 Y14 A112 R114 Y115 I167 A168 G170 M171 R234 S326 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bs8 D 2.40 BS02 NUC F 1 E459 D461 G483 K484 D536 E31 D33 G55 K56 D108 5.99.1.3 26792525 NALVRRKSGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bs8 D 2.40 BS04 NUC H 1 E459 D461 G483 K484 D536 I540 E31 D33 G55 K56 D108 I112 5.99.1.3 26792525 NALVRRKSGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bs8 D 2.40 BS06 MFX G 1 R482 G483 E501 R54 G55 E73 5.99.1.3 26792525 NALVRRKSGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bta A 2.55 BS01 NUC E 1 R39 V51 H52 H85 H87 S95 R98 I181 R25 V37 H38 H71 H73 S81 R84 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bta A 2.55 BS02 NUC F 1 Y28 A126 R128 Y129 I181 A182 G184 M185 R248 K333 Y14 A112 R114 Y115 I167 A168 G170 M171 R234 K319 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bta A 2.55 BS03 NUC G 1 R39 K49 H52 H85 H87 S95 R98 G179 I181 R25 K35 H38 H71 H73 S81 R84 G165 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bta B 2.55 BS03 NUC G 1 E459 D461 G483 K484 R492 D536 E29 D31 G53 K54 R62 D106 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bta B 2.55 BS06 MFX H 1 R482 T500 R52 T70 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bta C 2.55 BS01 NUC E 1 Y28 A126 R128 Y129 I181 A182 G184 M185 R248 Y14 A112 R114 Y115 I167 A168 G170 M171 R234 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bta C 2.55 BS02 NUC F 1 R39 V51 H52 H85 H87 G88 S95 R98 G179 I181 R25 V37 H38 H71 H73 G74 S81 R84 G165 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bta C 2.55 BS03 NUC G 1 Y28 R128 Y129 I181 A182 V183 G184 M185 R248 Y14 R114 Y115 I167 A168 V169 G170 M171 R234 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bta D 2.55 BS05 MG D 1 E459 D532 D534 E31 D104 D106 5.99.1.3 26792525 NALVRRKSGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5bta D 2.55 BS06 MFX G 1 R482 G483 R54 G55 5.99.1.3 26792525 NALVRRKSGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5btc A 2.55 BS02 NUC F 1 Y28 A126 R128 Y129 I181 A182 G184 M185 K333 Y14 A112 R114 Y115 I167 A168 G170 M171 K319 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btc C 2.55 BS02 NUC F 1 R39 V51 H52 H85 H87 S95 R98 G179 I181 R25 V37 H38 H71 H73 S81 R84 G165 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btd B 2.50 BS01 NUC E 1 E459 D461 G483 D536 I540 E29 D31 G53 D106 I110 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5btd C 2.50 BS03 NUC G 1 Y28 Y129 I181 A182 V183 G184 M185 A186 R248 Y14 Y115 I167 A168 V169 G170 M171 A172 R234 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btf A 2.61 BS02 NUC F 1 Y28 A126 R128 Y129 I181 A182 G184 M185 Y14 A112 R114 Y115 I167 A168 G170 M171 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btf A 2.61 BS04 NUC H 1 Y28 R128 Y129 I181 A182 V183 G184 M185 A186 R248 Y14 R114 Y115 I167 A168 V169 G170 M171 A172 R234 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btf C 2.61 BS02 NUC F 1 R39 V51 H52 H85 H87 G88 S95 R98 I181 R25 V37 H38 H71 H73 G74 S81 R84 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btf C 2.61 BS03 NUC G 1 Y28 Y129 I181 A182 G184 M185 R248 Y14 Y115 I167 A168 G170 M171 R234 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btf C 2.61 BS04 NUC H 1 R39 K49 H85 H87 S95 R98 I181 R25 K35 H71 H73 S81 R84 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btg A 2.50 BS01 NUC E 1 R39 V51 H52 H85 H87 S91 S95 R98 I181 Q277 R25 V37 H38 H71 H73 S77 S81 R84 I167 Q263 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btg B 2.50 BS01 NUC E 1 E459 D461 G483 R492 D536 I540 E29 D31 G53 R62 D106 I110 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5btg B 2.50 BS06 LFX E 1 R482 G483 T500 E501 R52 G53 T70 E71 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5btg C 2.50 BS03 NUC G 1 Y28 Y129 I181 A182 V183 G184 M185 R248 Y14 Y115 I167 A168 V169 G170 M171 R234 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bti A 2.50 BS04 NUC H 1 Y28 R128 Y129 I181 A182 V183 G184 M185 Y14 R114 Y115 I167 A168 V169 G170 M171 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5bti B 2.50 BS06 LFX E 1 G483 T500 G53 T70 5.99.1.3 26792525 ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5btl A 2.50 BS02 NUC F 1 Y28 A126 R128 Y129 I181 G184 K333 Y14 A112 R114 Y115 I167 G170 K319 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btl A 2.50 BS04 NUC H 1 Y28 A126 R128 Y129 I181 A182 V183 G184 M185 A186 Y14 A112 R114 Y115 I167 A168 V169 G170 M171 A172 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btn A 2.50 BS01 NUC E 1 R39 K49 V51 H52 H85 H87 G88 S95 R98 G179 I181 Q277 R25 K35 V37 H38 H71 H73 G74 S81 R84 G165 I167 Q263 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btn C 2.50 BS04 NUC H 1 R39 K49 V51 H52 H85 H87 R98 I181 R25 K35 V37 H38 H71 H73 R84 I167 5.99.1.3 26792525 IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDSSIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI 5btn D 2.50 BS06 8MX G 1 T500 E501 T72 E73 5.99.1.3 26792525 NALVRRKSGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV 5c1o A 2.50 BS01 ANP A 1 K97 I142 K144 M154 E180 K181 W182 L183 E187 Y210 D211 M259 L269 E270 K97 I142 K144 M150 E176 K177 W178 L179 E183 Y206 D207 M250 L260 E261 6.3.2.4 26894530 MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5c1o B 2.50 BS01 ANP B 1 K97 I142 K144 E148 S151 M154 E180 K181 W182 L183 E187 M259 E270 K97 I142 K144 E148 S149 M152 E178 K179 W180 L181 E185 M243 E254 6.3.2.4 26894530 MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHESVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5c1o B 2.50 BS02 MG B 1 K97 E148 E270 K97 E148 E254 6.3.2.4 26894530 MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHESVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5c1o C 2.50 BS02 MG C 1 E148 E270 E148 E270 6.3.2.4 26894530 MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHEGSSVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKYLSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5c1p B 2.40 BS01 ADP B 1 K97 I142 K144 E180 K181 W182 L183 E187 Y210 M259 L269 E270 K97 I142 K144 E176 K177 W178 L179 E183 Y206 M251 L261 E262 6.3.2.4 26894530 MAEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5c1p D 2.40 BS01 ADP D 1 K97 I142 K144 E148 E180 K181 W182 L183 E187 F209 Y210 M259 E270 K96 I141 K143 E147 E176 K177 W178 L179 E183 F205 Y206 M255 E266 6.3.2.4 26894530 AEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHEVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKYLSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5c1p D 2.40 BS02 DAL D 1 H63 Y216 R255 N272 P275 G276 H62 Y212 R251 N268 P271 G272 6.3.2.4 26894530 AEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHEVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKYLSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5c1p D 2.40 BS03 DAL D 2 Y210 K215 Y216 R255 G276 S281 L282 Y206 K211 Y212 R251 G272 S277 L278 6.3.2.4 26894530 AEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGIDAYGVDTKDFPVTQLKEQGFDKVFIALHGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQFETLSPEELVACVAKLGLPLIVKPSHEVGMSKVDHASELQKALVEAFQHDSDVLIEKWLSGPEFTVAILGDEVLPSIRIQPPGVFYDYDAKYLSDKTQYFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNTSPGMTSHSLVPMAARQYGLSFSQLVARILMLAD 5ckr A 2.95 BS01 57M A 1 K70 T75 N190 D193 G194 L195 D196 N255 F262 M263 G264 S268 V302 Q305 R320 A321 P322 H325 K40 T45 N160 D163 G164 L165 D166 N225 F232 M233 G234 S238 V272 Q275 R290 A291 P292 H295 2.7.8.13 KYITFRSFTAVLIAFFLTLVLSPSFINRLRKIQRLFGGVKKYTPTMGGIVILIVVTLSTLLLMRWDIKYTWVVLLSFLSFGTIGFWDDYVKLKNKKGISIKTKFLLQVLSASLISVLIYYWADIDTILYFPFFKELYVDLGVLYLPFAVFVIVGSANAVNLTDGLDGLAIGPAMTTATALGVVAYAVGHSKIAQYLNIPYVPYAGELTVFCFALVGAGLGFLWFNSFPAQMFMGDVGSLSIGASLATVALLTKSEFIFAVAAGVFVFETISVILQIIYFRWTGGKRLFKRAPFHHHLELNGLPEPKIVVRMWIISILLAIIAISMLKLR 5cuu A 2.96 BS01 4GA A 1 K237 Y261 D323 K369 K205 Y229 D291 K337 NSYIGTGLDTSLENVKPLPEACKRNVTEFDLVAYGKDEFTLSMEKRVMARMFSAFDVTQLGYLEERKIEHMCKYLGRVMNEDDVKQMKSEINAIDGHITFEKFWAWWCSHPEVPAKKDFFSMVSVDFAVPYHQQQLLTRETGELYTPSYRVLYYFRDMETGKELQVSPWHDIPLYVRDLVRTKPASLPMNRYNFICEIPKWTRAKFEIATGEPFNPIKQDIKNGVPRFYKHGDMMWNYGALPQTWESTDVVFEGGYVGDNDPIDAIEIGMTQFKVGQVGAVKVLGILGMIDDGQMDWKVICISHNDPICRFLKDIHDVPKFLPGCLDAIHEWFRVYKICQGGVENKFVFNGEFKDKSFAMKVIDESHYMWGNLRKINK 5cuu B 2.96 BS01 4GA B 1 K237 Y261 D323 Y368 K369 K206 Y230 D292 Y337 K338 ANSYIGTGLDTSLENVKPLPEACKRNVTEFDLVAYGKDEFTLSMEKRVMARMFSAFDVTQLGYLEERKIEHMCKYLGRVMNEDDVKQMKSEINAIDGHITFEKFWAWWCSHPEVPAKKDFFSMVSVDFAVPYHQQQLLTRETGELYTPSYRVLYYFRDMETGKELQVSPWHDIPLYVRDLVRTKPASLPMNRYNFICEIPKWTRAKFEIATGEPFNPIKQDIKNGVPRFYKHGDMMWNYGALPQTWESTDVVFEGGYVGDNDPIDAIEIGMTQFKVGQVGAVKVLGILGMIDDGQMDWKVICISHNDPICRFLKDIHDVPKFLPGCLDAIHEWFRVYKICQGGVENKFVFNGEFKDKSFAMKVIDESHYMWGNLRKINK 5cuv A 2.62 BS01 MG A 1 D291 D296 D328 D259 D264 D296 NSYIGTGLDTSLENVKPLPEACKRNVTEFDLVAYGKDEFTLSMEKRVMARMFSAFDVTQLGYLEERKIEHMCKYLGRVMNEDDVKQMKSEINAIDGHITFEKFWAWWCSHPEVPAKKDFFSMVSVDFAVPYHQQQLLTRETGELYTPSYRVLYYFRDMETGKELQVSPWHDIPLYVRDLVRTKPASLPMNRYNFICEIPKWTRAKFEIATGEPFNPIKQDIKNGVPRFYKHGDMMWNYGALPQTWESTDVVFEGGYVGDNDPIDAIEIGMTQFKVGQVGAVKVLGILGMIDDGQMDWKVICISHNDPICRFLKDIHDVPKFLPGCLDAIHEWFRVYKICQGGVENKFVFNGEFKDKSFAMKVIDESHYMWGNLRKINKKEEV 5cux A 2.80 BS01 POP A 1 R213 K215 L219 P220 M221 N222 R223 R68 K70 L74 P75 M76 N77 R78 MAKKDFFSMVSVDFAVPYHQQQLLTRETGELYTPSYRVLYYFRDMETGKELQVSPWHDIPLYVRDLVRTKPASLPMNRYNFICEIPKWTRAKFEIATGEPFNPIKQDIKNGVPRFYKHGDMMWNYGALPQTWESTDVVFEGGYVGDNDPIDAIEIGMTQFKVGQVGAVKVLGILGMIDDGQMDWKVICISHNDPICRFLKDIHDVPKFLPGCLDAIHEWFRVYKICQGGVENKFVFNGEFKDKSFAMKVIDESHYMWGNLRKI 5cux A 2.80 BS02 POP A 2 K237 D323 Y368 K369 K92 D178 Y223 K224 MAKKDFFSMVSVDFAVPYHQQQLLTRETGELYTPSYRVLYYFRDMETGKELQVSPWHDIPLYVRDLVRTKPASLPMNRYNFICEIPKWTRAKFEIATGEPFNPIKQDIKNGVPRFYKHGDMMWNYGALPQTWESTDVVFEGGYVGDNDPIDAIEIGMTQFKVGQVGAVKVLGILGMIDDGQMDWKVICISHNDPICRFLKDIHDVPKFLPGCLDAIHEWFRVYKICQGGVENKFVFNGEFKDKSFAMKVIDESHYMWGNLRKI 5cux B 2.80 BS01 POP B 1 R213 K215 L219 P220 M221 N222 H336 R62 K64 L68 P69 M70 N71 H185 FSMVSVDFAVPYHQQQLLTRETGELYTPSYRVLYYFRDMETGKELQVSPWHDIPLYVRDLVRTKPASLPMNRYNFICEIPKWTRAKFEIATGEPFNPIKQDIKNGVPRFYKHGDMMWNYGALPQTWESTDVVFEGGYVGDNDPIDAIEIGMTQFKVGQVGAVKVLGILGMIDDGQMDWKVICISHNDPICRFLKDIHDVPKFLPGCLDAIHEWFRVYKICQGGVENKFVFNGEFKDKSFAMKVIDESHYMWGNLRKI 5cuy A 2.50 BS01 MG A 1 D291 D293 P294 D296 D328 D274 D276 P277 D279 D311 DLASAEVAGLPVSALHGTNISTGRGSEADVAEPIQEAVDRKVSELDLAAYDKDDFTQPMIKKIMSRLFSAFDVTHLGYLTPDKVEEVCRYLGRNMSDGDVKAMKAEINAIDGHVTFEKFWAWWCSHPVHSRTKCFSMVSADFSMPYHQQQLVVHEKGEMYTPSYRVLYFFRDLETGRERQVSPWHDIPLYVRDLVRTKPEATPMNRYNFICEIPKWTRAKFEIATGESFNPIKQDIKNGVPRFYKHGDMMWNYGAFPQTWESTEVLFEAGVTGDNDPVDAVEIGMTQFKVGQVSAVKVLGVLGMIDEGEMDWKVVCISHSDPICHFLRDIHDVPKFLPGCLDAIREWFRVYKICQGGEASHFAFDGEFKDKEYAMKVIDESHNMWHNLRKVN 5cuy B 2.50 BS01 MG B 1 D296 D328 D274 D306 ASAEVAGLPVSALHGTNISTGRGSEADVAEPIQEAVDRKVSELDLAAYDKDDFTQPMIKKIMSRLFSAFDVTHLGYLTPDKVEEVCRYLGRNMSDGDVKAMKAEINAIDGHVTFEKFWAWWCSHPVHSRTKCFSMVSADFSMPYHQQQLVVHEKGEMYTPSYRVLYFFRDLETGRERQVSPWHDIPLYVRDLVRTKPEATPMNRYNFICEIPKWTRAKFEIATGESFNPIKQDIKNGVPRFYKHGDMMWNYGAFPQTWESTEEAGVTGDNDPVDAVEIGMTQFKVGQVSAVKVLGVLGMIDEGEMDWKVVCISHSDPICHFLRDIHDVPKFLPGCLDAIREWFRVYKICQGGEASHFAFDGEFKDKEYAMKVIDESHNMWHNLRKVNK 5cuy D 2.50 BS01 MG D 1 D291 D296 D328 D275 D280 D312 QDLASAEVAGLPVSALHGTNISTGRGSEADVAEPIQEAVDRKVSELDLAAYDKDDFTQPMIKKIMSRLFSAFDVTHLGYLTPDKVEEVCRYLGRNMSDGDVKAMKAEINAIDGHVTFEKFWAWWCSHPVHSRTKCFSMVSADFSMPYHQQQLVVHEKGEMYTPSYRVLYFFRDLETGRERQVSPWHDIPLYVRDLVRTKPEATPMNRYNFICEIPKWTRAKFEIATGESFNPIKQDIKNGVPRFYKHGDMMWNYGAFPQTWESTEVLFEAGVTGDNDPVDAVEIGMTQFKVGQVSAVKVLGVLGMIDEGEMDWKVVCISHSDPICHFLRDIHDVPKFLPGCLDAIREWFRVYKICQGGEASHFAFDGEFKDKEYAMKVIDESHNMWHNLRKVNKRG 5d61 A 1.60 BS01 III L 1 W208 D214 C215 D216 V249 G253 A256 H257 Y289 W207 D213 C214 D215 V248 G252 A255 H256 Y288 26901797 SLRRGIYHIENAGVPSAIDLKDGSSSDGTPIVGWQFTPDTINWHQLWLAEPIPNVADTFTLCNLFSGTYMDLYNGSSEAGTAVNGWQGTAFTTNPHQLWTIKKSSDGTSYKIQNYGSKTFVDLVNGDSSDGAKIAGWTGTWDEGNPHQKWYFNRMSVSSAEAQAAIARNPHIHGTYRGYILDGEYLVLPNATFTQIWKDSGLPGSKWREQIYDCDDFAIAMKAAVGKWGADSWKANGFAIFCGVMLGVNKAGDAAHAYNFTLTKDHADIVFFEPQNGGYLNDIGYDSYMAFY 5d62 A 1.70 BS01 III L 1 W208 D214 C215 A256 H257 E274 Q276 N277 W207 D213 C214 A255 H256 E273 Q275 N276 26901797 SLRRGIYHIENAGVPSAIDLKDGSSSDGTPIVGWQFTPDTINWHQLWLAEPIPNVADTFTLCNLFSGTYMDLYNGSSEAGTAVNGWQGTAFTTNPHQLWTIKKSSDGTSYKIQNYGSKTFVDLVNGDSSDGAKIAGWTGTWDEGNPHQKWYFNRMSVSSAEAQAAIARNPHIHGTYRGYILDGEYLVLPNATFTQIWKDSGLPGSKWREQIYDCDDFAIAMKAAVGKWGADSWKANGFAIFCGVMLGVNKAGDAAHAYNFTLTKDHADIVFFEPQNGGYLNDIGYDSYMAFY 5d63 A 1.65 BS01 III L 1 W208 D214 C215 D216 G253 A256 H257 Y289 W207 D213 C214 D215 G252 A255 H256 Y288 26901797 SLRRGIYHIENAGVPSAIDLKDGSSSDGTPIVGWQFTPDTINWHQLWLAEPIPNVADTFTLCNLFSGTYMDLYNGSSEAGTAVNGWQGTAFTTNPHQLWTIKKSSDGTSYKIQNYGSKTFVDLVNGDSSDGAKIAGWTGTWDEGNPHQKWYFNRMSVSSAEAQAAIARNPHIHGTYRGYILDGEYLVLPNATFTQIWKDSGLPGSKWREQIYDCDDFAIAMKAAVGKWGADSWKANGFAIFCGVMLGVNKAGDAAHAYNFTLTKDHADIVFFEPQNGGYLNDIGYDSYMAFY 5d6j A 2.25 BS01 ATP A 1 T187 S188 G189 S190 T191 R192 S314 E315 P316 S342 G344 L345 A346 D469 I480 R483 T187 S188 G189 S190 T191 R192 S314 E315 P316 S342 G344 L345 A346 D469 I480 R483 26628098 MPFHNPFIKDGQIKFPDGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVIAVDAVPDDVASTWVNPDEPDETTIAYLQYTSGSTRIPTGVQITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVRTGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKAIRTGYVAAFSVPANQLPDEVFENAHSGIKRDPDDTSEQLVIVAERAPGAHKLDIGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLDGSLRAGKVANDFPDATD 5da9 A 3.00 BS01 MG A 1 T41 Q159 D1237 T40 Q158 D359 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKILKEREVQDKANKERAEKVDELDLKDAKAKYKETHIKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDEPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESIT 5da9 A 3.00 BS02 AGS A 1 R13 S14 N36 G37 S38 G39 K40 T41 T42 A64 I66 H67 D68 Q159 H1275 R1297 R12 S13 N35 G36 S37 G38 K39 T40 T41 A63 I65 H66 D67 Q158 H397 R419 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKILKEREVQDKANKERAEKVDELDLKDAKAKYKETHIKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDEPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESIT 5da9 A 3.00 BS03 AGS B 1 D1164 M1201 R1206 S1208 A1209 G1210 Q1211 D289 M323 R328 S330 A331 G332 Q333 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKILKEREVQDKANKERAEKVDELDLKDAKAKYKETHIKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDEPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESIT 5da9 B 3.00 BS01 AGS A 1 M1194 R1206 S1208 A1209 G1210 Q1211 M282 R294 S296 A297 G298 Q299 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDEPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESITR 5da9 B 3.00 BS02 MG B 1 T41 Q159 D1237 T40 Q158 D325 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDEPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESITR 5da9 B 3.00 BS03 AGS B 1 R13 S14 N36 G37 G39 K40 T41 T42 A64 I66 D68 H1275 R12 S13 N35 G36 G38 K39 T40 T41 A63 I65 D67 H363 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDEPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESITR 5dac A 2.50 BS01 NUC C 1 N58 R61 N57 R60 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKILKEREVQDKANKERAEDLKDAKAKYKETHIKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDQPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESITR 5dac A 2.50 BS02 NUC D 1 R61 T110 Q111 K112 T113 V133 R60 T109 Q110 K111 T112 V132 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKILKEREVQDKANKERAEDLKDAKAKYKETHIKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDQPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESITR 5dac A 2.50 BS03 MG A 1 T41 Q159 T40 Q158 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKILKEREVQDKANKERAEDLKDAKAKYKETHIKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDQPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESITR 5dac A 2.50 BS04 AGS A 1 R13 S14 N36 G37 S38 G39 K40 T41 T42 A64 I66 D68 L71 Q159 H1275 R1297 R12 S13 N35 G36 S37 G38 K39 T40 T41 A63 I65 D67 L70 Q158 H395 R417 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKILKEREVQDKANKERAEDLKDAKAKYKETHIKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDQPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESITR 5dac A 2.50 BS05 AES A 1 T1151 L1221 A1224 E1225 G1232 I1258 R1262 L1268 T271 L341 A344 E345 G352 I378 R382 L388 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKILKEREVQDKANKERAEDLKDAKAKYKETHIKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDQPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESITR 5dac B 2.50 BS04 AES B 1 E1154 L1155 L1221 A1224 E1225 I1234 R1262 E275 L276 L342 A345 E346 I355 R383 SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYATTGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQLLVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAILDAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGDELKILKEREVQDKANKERAELDLKDAKAKYKETHIKVETTKAAIEDLGRGMAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTSSDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCANCGLIALDQPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEFLKYMQCSDFCDDFYRVKRDEKQNSVIVRESIT 5dfs A 1.15 BS01 HEM A 1 F10 K13 C14 Q16 C17 H18 T28 G29 P30 L32 L35 T40 G41 F46 Y48 T49 N52 W59 L64 Y67 L68 T78 K79 M80 I81 F82 I85 L94 L98 F10 K13 C14 Q16 C17 H18 T28 G29 P30 L32 L35 T40 G41 F46 Y48 T49 N52 W59 L64 Y67 L68 T78 K79 M80 I81 F82 I85 L94 L98 26775610 GDVEKGKRIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQASGFTYTEANKNKGIIWGEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE 5dir A 2.80 BS01 MLE A 1 F73 A77 V80 N112 I146 F72 A76 V79 N111 I145 3.4.23.36 PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMF 5dir A 2.80 BS02 IIL A 1 N112 R116 D143 I146 N111 R115 D142 I145 3.4.23.36 PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMF 5dir A 2.80 BS03 SER A 1 N54 R116 V122 D124 N140 D143 N53 R115 V121 D123 N139 D142 3.4.23.36 PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMF 5dir A 2.80 BS04 ALO A 1 N54 F59 N53 F58 3.4.23.36 PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMF 5dir A 2.80 BS05 5BV A 1 F59 L62 L72 F73 R116 F58 L61 L71 F72 R115 3.4.23.36 PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMF 5dir B 2.80 BS01 MLE B 1 I76 A77 N112 R116 I146 I69 A70 N105 R109 I139 3.4.23.36 PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALD 5dir B 2.80 BS02 IIL B 1 R116 D143 T147 R109 D136 T140 3.4.23.36 PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALD 5dir B 2.80 BS03 SER B 1 T55 R116 V122 D124 D143 T54 R109 V115 D117 D136 3.4.23.36 PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALD 5dir B 2.80 BS04 5BV B 1 F73 I76 R116 F66 I69 R109 3.4.23.36 PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALD 5dir C 2.80 BS01 MLE C 1 F73 I76 A77 N112 R116 I146 F63 I66 A67 N102 R106 I136 3.4.23.36 PWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFR 5dir C 2.80 BS02 IIL C 1 R116 D143 I146 R106 D133 I136 3.4.23.36 PWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFR 5dir C 2.80 BS04 ALO C 1 N54 G56 F59 F73 N44 G46 F49 F63 3.4.23.36 PWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFR 5dir D 2.80 BS01 MLE D 1 F73 A77 V80 A109 N112 R116 I146 F63 A67 V70 A99 N102 R106 I136 3.4.23.36 PWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFR 5dir D 2.80 BS03 SER D 1 N54 R116 V122 D124 D143 N44 R106 V112 D114 D133 3.4.23.36 PWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFR 5dir D 2.80 BS04 ALO D 1 N54 A57 F59 N44 A47 F49 3.4.23.36 PWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFR 5dir D 2.80 BS05 5BV D 1 F59 F73 I76 F49 F63 I66 3.4.23.36 PWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFR 5e6l A 2.10 BS02 5KU A 1 R118 E119 D151 R152 R156 W179 I223 E228 A247 E277 E278 K293 R371 Y405 R37 E38 D70 R71 R75 W98 I142 E147 A166 E196 E197 K212 R290 Y324 3.2.1.18 RNFNNLTKGLCTINSWHIYGKDNAVRIGESSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKSRMSICISGPNNNASAVVWYNRRPVAEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPADTRIYYFKEGKILKWESLTGTAKHIEECSCYGERTGITCTCKDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPNDPNIGKCNDPYPGNNNNGVKGFSYLDGANTWLGRTISTASRSGYEMLKVPNALTDDRSKPIQGQTIVLNADWSGYSGSFMDYWAEGDCYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL 5e6r A 2.90 BS01 MG A 1 D137 S139 S141 T206 D239 D137 S139 S141 T206 D239 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPV 5e6r A 2.90 BS02 CA A 1 D443 D445 D447 E449 E451 D434 D436 D438 E440 E442 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPV 5e6r A 2.90 BS03 CA A 2 D505 N507 D509 L511 V512 D513 D496 N498 D500 L502 V503 D504 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPV 5e6r B 2.90 BS01 CA B 1 S116 M117 D119 D120 E325 S111 M112 D114 D115 E320 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNC 5e6r B 2.90 BS02 CA B 2 D151 F157 N207 D209 A210 P211 H246 D146 F152 N202 D204 A205 P206 H241 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNC 5e6s A 2.15 BS02 CA A 1 D443 D447 E449 E451 D433 D437 E439 E441 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKILTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRP 5e6s A 2.15 BS03 CA A 2 D505 N507 D509 L511 D513 D495 N497 D499 L501 D503 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKILTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRP 5e6s A 2.15 BS04 CA A 3 D565 L566 E567 D569 L571 D573 D555 L556 E557 D559 L561 D563 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKILTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRP 5e6s B 2.15 BS02 CA B 2 D151 F157 N207 D209 P211 E212 D147 F153 N203 D205 P207 E208 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNC 5e6s C 2.15 BS01 MG C 1 S139 S141 T206 D239 S139 S141 T206 D239 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPV 5e6s C 2.15 BS04 CA C 3 D565 D569 L571 D573 D553 D557 L559 D561 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPV 5e6s E 2.15 BS01 MG E 1 S139 S141 D239 S139 S141 D239 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKILTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPV 5e6s E 2.15 BS04 CA E 3 D565 D569 L571 D573 S586 D555 D559 L561 D563 S576 YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKILTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPV 5e6s F 2.15 BS02 CA F 2 D151 F157 N207 D209 P211 E212 H246 D147 F153 N203 D205 P207 E208 H242 QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNC 5e9o B 2.10 BS01 I3C B 1 Y459 N503 A520 S521 D522 Y526 Y3 N47 A64 S65 D66 Y70 26868291 GEYTEIALPFSYDGAGEYYWKTDQFSTDPNDWSRYVNSWNLDLLEINATDYTNVWVAQHQIPAASDGYWYIHYKSGVSWGHVEIK 5e9o C 2.10 BS01 I3C C 1 G457 E458 E473 Y475 G1 E2 E17 Y19 26868291 GEYTEIALPFSYDGAGEYYWKTDQFSTDPNDWSRYVNSWNLDLLEINATDYTNVWVAQHQIPAASDGYWYIHYKSGVSWGHVEIK 5e9o C 2.10 BS02 I3C C 2 W488 H515 Q516 W32 H59 Q60 26868291 GEYTEIALPFSYDGAGEYYWKTDQFSTDPNDWSRYVNSWNLDLLEINATDYTNVWVAQHQIPAASDGYWYIHYKSGVSWGHVEIK 5e9o D 2.10 BS01 I3C D 1 G472 E473 D498 K530 S531 G532 G16 E17 D42 K74 S75 G76 26868291 GEYTEIALPFSYDGAGEYYWKTDQFSTDPNDWSRYVNSWNLDLLEINATDYTNVWVAQHQIPAASDGYWYIHYKSGVSWGHVEIK 5e9o D 2.10 BS02 I3C D 2 N503 A519 A520 S521 N47 A63 A64 S65 26868291 GEYTEIALPFSYDGAGEYYWKTDQFSTDPNDWSRYVNSWNLDLLEINATDYTNVWVAQHQIPAASDGYWYIHYKSGVSWGHVEIK 5e9u A 3.84 BS01 UDP A 1 S15 G16 Y19 A326 R328 Y357 H384 A385 L387 L408 T409 S15 G16 Y19 A326 R328 Y357 H384 A385 L387 L408 T409 2.4.1.- 26884191 STVYNINLGIGWASSGVEYAQAYRAQILRRIQQPAKFIFMDMILADNIQHLTENIGFLDEEIIWLYNYFTDIKIAPTTVTLDQVLAQVAGQPERSEKEGKIVRYFYPQDDQFITCYLRQEDQDFVEHVEYVSRGRLIRKDYFSYVRYASEYFAPHNDAATLYQRRFYHEDGSVAYDMLIEDGQEKLYRFPDRIFYSKAELVRYFLQCLQLQADDVVILDRETGIGQVVFEESQKAKLGVVVHAEHFSENASSDDYILWNNFYDYQFTNADKVDFFIVATEAQKRILEQQFQHYSDKQPQIATIPVGSLDQLTYPKEPRKPYSMITASRLATEKHIDWLVAATVQAHAQLPELTLDIYGKGSEEDKLRRRIEEAGAQDYIRLKGHADLSQIYAGYELYLTASTSEGFGLTLMEAVGSGLPLIGFDVRYGNQTFIDDGKNGYLLPVSSNHVEDQIIAAFVEKIIALFSQGRQQEMSQHSYQVAENYLTSRVEAAWTQLLKEVRDD 5e9u A 3.84 BS02 NAG A 1 H242 A243 V305 S403 E404 G405 F406 G407 L408 H242 A243 V305 S403 E404 G405 F406 G407 L408 2.4.1.- 26884191 STVYNINLGIGWASSGVEYAQAYRAQILRRIQQPAKFIFMDMILADNIQHLTENIGFLDEEIIWLYNYFTDIKIAPTTVTLDQVLAQVAGQPERSEKEGKIVRYFYPQDDQFITCYLRQEDQDFVEHVEYVSRGRLIRKDYFSYVRYASEYFAPHNDAATLYQRRFYHEDGSVAYDMLIEDGQEKLYRFPDRIFYSKAELVRYFLQCLQLQADDVVILDRETGIGQVVFEESQKAKLGVVVHAEHFSENASSDDYILWNNFYDYQFTNADKVDFFIVATEAQKRILEQQFQHYSDKQPQIATIPVGSLDQLTYPKEPRKPYSMITASRLATEKHIDWLVAATVQAHAQLPELTLDIYGKGSEEDKLRRRIEEAGAQDYIRLKGHADLSQIYAGYELYLTASTSEGFGLTLMEAVGSGLPLIGFDVRYGNQTFIDDGKNGYLLPVSSNHVEDQIIAAFVEKIIALFSQGRQQEMSQHSYQVAENYLTSRVEAAWTQLLKEVRDD 5e9u D 3.84 BS01 MG D 1 W70 D83 W70 D83 26884191 MIQLFDYYNQETQDLHDSLLAAGYACPTIVIEANGFLPDDMISPYTYFLGDEEGVDHPLFFNQVPVPPFWEITGDHQVARVSDMGEERARIHYASQARGRLVKQVDWLDKKGQLRLSERYNKQGRCFAKTAYKSGQEAFNTTYYSTDGQERIVENHVTGDIILTLDQEPLRIFKSRVDFIRFFLERLDLDLDHILFNSLAYSFLVSHSLTGRAGQDILFWQEPLYDELPGNMQLILDNSQLRTQTIVIPDLATYEKAMSLAAADQQQKFLHLGYHYDFKRDNYLRKDALILTHSDQIEGLDTLVQSLPQLVFRIAALTEMSPKLLSMLSYKNVVLYQNASLKQIEQLYLESDIYLDINHGGQVLQAVRKAFENNLLILGFEQTLHDRHYIAQQHIFDSSQPAQLASILEEALCGVEQMRSALQAQGRHANDVPVSLYQETLQSLLG 5e9u E 3.84 BS01 MG E 1 Q226 E230 Q226 E230 2.4.1.- 26884191 STVYNINLGIGWASSGVEYAQAYRAQILRRIQQPAKFIFMDMILADNIQHLTENIGFLDEEIIWLYNYFTDIKIAPTTVTLDQVLAQVAGQPERSEKEGKIVRYFYPQDDQFITCYLRQEDQDFVEHVEYVSRGRLIRKDYFSYVRYASEYFAPHNDAATLYQRRFYHEDGSVAYDMLIEDGQEKLYRFPDRIFYSKAELVRYFLQCLQLQADDVVILDRETGIGQVVFEESQKAKLGVVVHAEHFSENASSDDYILWNNFYDYQFTNADKVDFFIVATEAQKRILEQQFQHYSDKQPQIATIPVGSLDQLTYPKEPRKPYSMITASRLATEKHIDWLVAATVQAHAQLPELTLDIYGKGSEEDKLRRRIEEAGAQDYIRLKGHADLSQIYAGYELYLTASTSEGFGLTLMEAVGSGLPLIGFDVRYGNQTFIDDGKNGYLLPVSSNHVEDQIIAAFVEKIIALFSQGRQQEMSQHSYQVAENYLTSRVEAAWTQLLKEVRDD 5e9u E 3.84 BS02 UDP E 1 G16 Y19 R328 Y357 G358 G383 H384 A385 L387 T409 E412 G16 Y19 R328 Y357 G358 G383 H384 A385 L387 T409 E412 2.4.1.- 26884191 STVYNINLGIGWASSGVEYAQAYRAQILRRIQQPAKFIFMDMILADNIQHLTENIGFLDEEIIWLYNYFTDIKIAPTTVTLDQVLAQVAGQPERSEKEGKIVRYFYPQDDQFITCYLRQEDQDFVEHVEYVSRGRLIRKDYFSYVRYASEYFAPHNDAATLYQRRFYHEDGSVAYDMLIEDGQEKLYRFPDRIFYSKAELVRYFLQCLQLQADDVVILDRETGIGQVVFEESQKAKLGVVVHAEHFSENASSDDYILWNNFYDYQFTNADKVDFFIVATEAQKRILEQQFQHYSDKQPQIATIPVGSLDQLTYPKEPRKPYSMITASRLATEKHIDWLVAATVQAHAQLPELTLDIYGKGSEEDKLRRRIEEAGAQDYIRLKGHADLSQIYAGYELYLTASTSEGFGLTLMEAVGSGLPLIGFDVRYGNQTFIDDGKNGYLLPVSSNHVEDQIIAAFVEKIIALFSQGRQQEMSQHSYQVAENYLTSRVEAAWTQLLKEVRDD 5e9u E 3.84 BS03 NAG E 1 V17 H242 A243 V305 E404 G405 F406 V17 H242 A243 V305 E404 G405 F406 2.4.1.- 26884191 STVYNINLGIGWASSGVEYAQAYRAQILRRIQQPAKFIFMDMILADNIQHLTENIGFLDEEIIWLYNYFTDIKIAPTTVTLDQVLAQVAGQPERSEKEGKIVRYFYPQDDQFITCYLRQEDQDFVEHVEYVSRGRLIRKDYFSYVRYASEYFAPHNDAATLYQRRFYHEDGSVAYDMLIEDGQEKLYRFPDRIFYSKAELVRYFLQCLQLQADDVVILDRETGIGQVVFEESQKAKLGVVVHAEHFSENASSDDYILWNNFYDYQFTNADKVDFFIVATEAQKRILEQQFQHYSDKQPQIATIPVGSLDQLTYPKEPRKPYSMITASRLATEKHIDWLVAATVQAHAQLPELTLDIYGKGSEEDKLRRRIEEAGAQDYIRLKGHADLSQIYAGYELYLTASTSEGFGLTLMEAVGSGLPLIGFDVRYGNQTFIDDGKNGYLLPVSSNHVEDQIIAAFVEKIIALFSQGRQQEMSQHSYQVAENYLTSRVEAAWTQLLKEVRDD 5e9u G 3.84 BS01 MG G 1 R202 E230 R202 E230 2.4.1.- 26884191 STVYNINLGIGWASSGVEYAQAYRAQILRRIQQPAKFIFMDMILADNIQHLTENIGFLDEEIIWLYNYFTDIKIAPTTVTLDQVLAQVAGQPERSEKEGKIVRYFYPQDDQFITCYLRQEDQDFVEHVEYVSRGRLIRKDYFSYVRYASEYFAPHNDAATLYQRRFYHEDGSVAYDMLIEDGQEKLYRFPDRIFYSKAELVRYFLQCLQLQADDVVILDRETGIGQVVFEESQKAKLGVVVHAEHFSENASSDDYILWNNFYDYQFTNADKVDFFIVATEAQKRILEQQFQHYSDKQPQIATIPVGSLDQLTYPKEPRKPYSMITASRLATEKHIDWLVAATVQAHAQLPELTLDIYGKGSEEDKLRRRIEEAGAQDYIRLKGHADLSQIYAGYELYLTASTSEGFGLTLMEAVGSGLPLIGFDVRYGNQTFIDDGKNGYLLPVSSNHVEDQIIAAFVEKIIALFSQGRQQEMSQHSYQVAENYLTSRVEAAWTQLLKEVRDD 5ebt A 2.24 BS01 BU3 A 1 A1202 Y1203 F1208 G1209 A98 Y99 F104 G105 2.4.2.30 26546219 MTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE 5ebt A 2.24 BS02 5N8 A 1 H1184 G1185 F1188 F1197 D1198 H1201 A1202 F1208 G1211 I1212 Y1213 F1214 S1221 Y1224 I1228 E1291 H80 G81 F84 F93 D94 H97 A98 F104 G107 I108 Y109 F110 S117 Y120 I124 E187 2.4.2.30 26546219 MTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE 5ebt D 2.24 BS02 5N8 D 1 H1184 G1185 F1188 F1197 D1198 H1201 A1202 F1208 G1211 I1212 Y1213 S1221 Y1224 I1228 H79 G80 F83 F92 D93 H96 A97 F103 G106 I107 Y108 S116 Y119 I123 2.4.2.30 26546219 TILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPGLAYAEYVIYRGEQAYPEYLITYQIMKPE 5eoq H 1.95 BS01 III A 1 G36 W57 W58 D59 D61 R104 G105 Y106 G33 W54 W55 D56 D58 R101 G102 Y103 QVTLKESGPGILKPSQTLSLTCSFSGFSLSTSGMGVGWIRQPSGKGLEWLAHIWWDDDKYYNPSLQSQLTISKDTSRNQVFLKITSVDTADSATYYCAHDRGYYAMDYWGQGISVTVSSAKTTAPSVYPLAPVCGTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR 5eoq L 1.95 BS01 III A 1 H31 S32 Y37 Y54 K55 S96 T97 H98 V99 H31 S32 Y37 Y54 K55 S96 T97 H98 V99 DVVMTQTPLSLSVSLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRLSGSGSGTDFTLKISRVEAEDLAVYFCSQSTHVPPTFGGGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE 5eor H 2.27 BS01 III A 1 Y33 G34 H36 W53 S54 Y99 Y100 R101 Y102 Y32 G33 H35 W52 S53 Y98 Y99 R100 Y101 QVQLKQSGPGLVQPSQSLSITCTVSGLSLTSYGVHWVRQSPGKGLEWLGVIWSGGNTDYNAAFISRLSISKDNSKNQVFFKMNSLRADDTAIYYCAIYYRYGAYWGQGTLVTVSAAKTTAPSVYPLAPVCGDTGSSVTLGCLVKGYFPKPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR 5eor L 2.27 BS01 III A 1 T31 Y32 T33 D35 E50 G96 D97 T98 F103 T30 Y31 T32 D34 E49 G95 D96 T97 F102 QLVLTQSSSASFSLGASAKLTCTLSSQHSTYTIDWYQQQPLKPPKYVMELRRDGSHNTGDGIPDRFSGSSSGADRYLSISNIQPEDEAIYICGVGDTIKEQFVYVFGGGTKVTVLGQPKSTPTLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEGNKFMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPA 5erj A 1.45 BS01 CPT A 1 R64 H132 R64 H132 26888424 SSQIRQNYSTEVEAAVNRLVNLYLRASYTYLSLGFYFDRDDVALEGVCHFFRELAEEKREGAERLLKMQNQRGGRALFQDLQKPSQDEWGTTLDAMKAAIVLEKSLNQALLDLHALGSAQADPHLCDFLESHFLDEEVKLIKKMGDHLTNIQRLVGSQAGLGEYLFERLTLKH 5eu3 A 1.97 BS01 III C 1 M5 Y7 F9 M45 E63 K66 V67 H70 T73 V76 D77 R97 Y99 T143 K146 W147 Y159 T163 W167 Y171 M5 Y7 F9 M45 E63 K66 V67 H70 T73 V76 D77 R97 Y99 T143 K146 W147 Y159 T163 W167 Y171 GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP 5eu6 A 2.02 BS01 III C 1 Y7 F9 M45 E63 K66 V67 A69 H70 T73 V76 D77 Y84 Y99 Y116 T143 K146 W147 Q155 Y159 T163 W167 Y171 Y7 F9 M45 E63 K66 V67 A69 H70 T73 V76 D77 Y84 Y99 Y116 T143 K146 W147 Q155 Y159 T163 W167 Y171 GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP 5eu6 D 2.02 BS01 III C 1 S96 G97 S99 N100 Y101 S96 G97 S99 N100 Y101 MKQEVTQIPAALSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLLIQSSQREQTSGRLNASLDKSSGRSTLYIAASQPGDSATYLCAVLSSGGSNYKLTFGKGTLLTVNPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFS 5eu6 E 2.02 BS01 III C 1 T31 Q51 I98 G99 G100 T30 Q50 I97 G98 G99 GAGVSQTPSNKVTEKGKYVELRCDPISGHTALYWYRQSLGQGPEFLIYFQGTGAADDSGLPNDRFFAVRPEGSVSTLKIQRTERGDSAVYLCASSFIGGTDTQYFGPGTRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 5ewj A 2.77 BS01 QEL B 1 Y109 T110 S132 L135 Y82 T83 S105 L108 DPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLQATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFNGSYIIQNDRKIIWPGGET 5ewj B 2.77 BS01 QEL B 1 P78 A107 Q110 I111 F114 Y175 F176 P177 E236 P38 A67 Q70 I71 F74 Y135 F136 P137 E196 PPSIGIAVILVGTSDEVAIKDLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPR 5ewj C 2.77 BS01 QEL D 1 Y109 S132 I133 L135 Y81 S104 I105 L107 DPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLQATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFNGSYIIQNDRKIIWPGGET 5ewj D 2.77 BS01 QEL D 1 P78 Q110 I111 F114 Y175 F176 P177 E236 P41 Q73 I74 F77 Y138 F139 P140 E199 PPSIGIAVILVGTSDEVAIKDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEDLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRM 5ewl A 2.98 BS01 5SL A 1 Y109 T110 F113 S132 I133 L135 Y82 T83 F86 S105 I106 L108 DPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLQATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFNGSYIIQNDRKIIWPGGET 5ewl B 2.98 BS01 5SL A 1 P78 E106 A107 Q110 I111 F114 Y175 F176 P177 E236 P38 E66 A67 Q70 I71 F74 Y135 F136 P137 E196 PPSIGIAVILVGTSDEVAIKDLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWP 5ewl C 2.98 BS01 5SL C 1 A75 Y109 T110 F113 S132 I133 L135 A53 Y81 T82 F85 S104 I105 L107 DPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLQATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFNGSYIIQNDRKIIWPGGET 5ewm A 2.76 BS01 5SM B 1 Y109 T110 I133 Y82 T83 I106 DPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLQATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFNGSYIIQNDRKIIWPGGET 5ewm B 2.76 BS01 5SM B 1 P78 Q110 I111 F114 M134 A135 D136 P177 P41 Q73 I74 F77 M97 A98 D99 P140 PPSIGIAVILVGTSDEVAIKDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPR 5ewm D 2.76 BS01 5SM D 1 P78 I82 Q110 I111 F114 M134 A135 D136 P177 P41 I45 Q73 I74 F77 M97 A98 D99 P140 PPSIGIAVILVGTSDEVAIKDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEDLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRM 5f3w B 3.11 BS01 NUC F 1 A52 G53 S54 N57 Y58 R92 T107 I108 S109 K144 P145 A52 G53 S54 N57 Y58 R92 T107 I108 S109 K144 P145 26717941 MSMILKEIRMNNFKSHVNSRIKFEKGIVAIIGENGSGKSSIFEAVFFALFGAGSNFNYDTIITKGKKSVYVELDFEVNGNNYKIIREYDSGRGGAKLYKNGKPYATTISAVNKAVNEILGVDRNMFLNSIYIKQGEIAKFLSLKPSEKLETVAKLLGIDEFEKCYQKMGEIVKEYEKRLERIEGEKEMSNLEKEKEKLTKFVEYLDKVRRIFGRNGFQAYLREKYVPLIQKYLNEAFSEFDLPYSFVELTKDFEVRVHAPNGVLTIDNLSGGEQIAVALSLRLAIANALIGNRVECIILDEPTVYLDENRRAKLAEIFRKVKSIPQMIIITHHRELEDVADVIINVKKDGNVSKVKING 5f3w D 3.11 BS01 NUC E 1 G51 A52 S54 N57 Y58 R92 T107 I108 S109 K144 P145 G51 A52 S54 N57 Y58 R92 T107 I108 S109 K144 P145 26717941 MSMILKEIRMNNFKSHVNSRIKFEKGIVAIIGENGSGKSSIFEAVFFALFGAGSNFNYDTIITKGKKSVYVELDFEVNGNNYKIIREYDSGRGGAKLYKNGKPYATTISAVNKAVNEILGVDRNMFLNSIYIKQGEIAKFLSLKPSEKLETVAKLLGIDEFEKCYQKMGEIVKEYEKRLERIEGELNYNLEKEKEKLTKFVEYLDKVRRIFGRNGFQAYLREKYVPLIQKYLNEAFSEFDLPYSFVELTKDFEVRVHAPNGVLTIDNLSGGEQIAVALSLRLAIANALIGNRVECIILDEPTVYLDENRRAKLAEIFRKVKSIPQMIIITHHRELEDVADVIINVKKDGNVSKVKING 5f3w D 3.11 BS04 AGS D 1 K14 S15 E33 G35 S36 G37 K38 S39 S40 T60 I62 T63 K64 Q134 E947 K994 K14 S15 E33 G35 S36 G37 K38 S39 S40 T60 I62 T63 K64 Q134 E300 K347 26717941 MSMILKEIRMNNFKSHVNSRIKFEKGIVAIIGENGSGKSSIFEAVFFALFGAGSNFNYDTIITKGKKSVYVELDFEVNGNNYKIIREYDSGRGGAKLYKNGKPYATTISAVNKAVNEILGVDRNMFLNSIYIKQGEIAKFLSLKPSEKLETVAKLLGIDEFEKCYQKMGEIVKEYEKRLERIEGELNYNLEKEKEKLTKFVEYLDKVRRIFGRNGFQAYLREKYVPLIQKYLNEAFSEFDLPYSFVELTKDFEVRVHAPNGVLTIDNLSGGEQIAVALSLRLAIANALIGNRVECIILDEPTVYLDENRRAKLAEIFRKVKSIPQMIIITHHRELEDVADVIINVKKDGNVSKVKING 5f5r A 1.85 BS01 ANP A 1 N119 A123 D158 M163 N171 R177 G204 F205 T251 N50 A54 D89 M94 N102 R108 G135 F136 T182 PLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNT 5fc4 A 1.50 BS01 5WL A 1 A227 F228 M231 V249 M250 V253 G262 R263 T266 L267 F270 A47 F48 M51 V69 M70 V73 G82 R83 T86 L87 F90 26878343 GDELYRQSLEIISRYLREQATAGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIANEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIAPLAESITDVLVRTKRDWLVAQRGWDGFVEFFH 5fc4 A 1.50 BS02 5WL A 2 M231 K234 L235 R248 V249 H252 V253 D256 M51 K54 L55 R68 V69 H72 V73 D76 26878343 GDELYRQSLEIISRYLREQATAGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIANEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIAPLAESITDVLVRTKRDWLVAQRGWDGFVEFFH 5fc4 A 1.50 BS03 5WK A 1 R215 G262 V265 F319 R35 G82 V85 F139 26878343 GDELYRQSLEIISRYLREQATAGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIANEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIAPLAESITDVLVRTKRDWLVAQRGWDGFVEFFH 5fdo A 2.80 BS01 5X2 A 1 F228 M231 L235 L246 M250 V253 N260 G262 R263 T266 L267 F270 G271 I294 F50 M53 L57 L68 M72 V75 N82 G84 R85 T88 L89 F92 G93 I116 26878343 GDELYRQSLEIISRYLREQATGAKGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH 5fdo B 2.80 BS01 5X2 B 1 F228 M231 L246 V249 M250 N260 G262 R263 T266 L267 F270 G271 I294 F58 M61 L76 V79 M80 N90 G92 R93 T96 L97 F100 G101 I124 26878343 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH 5fdo C 2.80 BS01 5X2 C 1 H224 F228 M231 M250 V253 R263 T266 L267 F270 G271 H47 F51 M54 M73 V76 R86 T89 L90 F93 G94 26878343 GDELYRQSLEIISRYLREQATGAKDGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH 5fdo D 2.80 BS01 5X2 D 1 A227 F228 M231 L246 V249 M250 V253 G262 R263 T266 L267 F270 G271 A46 F47 M50 L65 V68 M69 V72 G79 R80 T83 L84 F87 G88 26878343 GDELYRQSLEIISRYLREQATGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH 5fdr A 2.60 BS01 5X3 A 1 H224 A227 F228 M231 M250 V253 N260 G262 R263 T266 L267 F270 G271 I294 H54 A57 F58 M61 M80 V83 N90 G92 R93 T96 L97 F100 G101 I124 26878343 DDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLE 5fdr B 2.60 BS01 5X3 B 1 A227 F228 M231 L246 V249 M250 V253 F254 D256 G257 R263 L267 F270 A55 F56 M59 L74 V77 M78 V81 F82 D84 G85 R91 L95 F98 26878343 DDELYRQSLEIISRYLREQATGAKDTMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 5fdr C 2.60 BS01 5X3 C 1 H224 A227 F228 M231 L235 L246 M250 V253 N260 G262 R263 T266 L267 F270 H43 A46 F47 M50 L54 L65 M69 V72 N79 G81 R82 T85 L86 F89 26878343 DELYRQSLEIISRYLREQATGGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDL 5fdr D 2.60 BS01 5X3 D 1 A227 F228 M231 L246 M250 V253 F254 D256 G257 R263 T266 L267 F270 I294 A54 F55 M58 L73 M77 V80 F81 D83 G84 R90 T93 L94 F97 I121 26878343 DELYRQSLEIISRYLREQATGAKDTMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 5fhm A 1.55 BS01 5XP A 1 E13 S14 Y16 Y61 P89 L90 T91 R96 L138 G141 S142 T143 L192 E193 T195 M196 Y199 Y220 E10 S11 Y13 Y58 P86 L87 T88 R93 L135 G138 S139 T140 L189 E190 T192 M193 Y196 Y217 26862980 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 5fhn A 1.60 BS01 5XO A 1 E13 S14 P15 Y16 Y61 P89 L90 T91 R96 L138 G141 S142 T143 L192 E193 T195 M196 Y199 Y220 W255 E9 S10 P11 Y12 Y57 P85 L86 T87 R92 L134 G137 S138 T139 L188 E189 T191 M192 Y195 Y216 W251 26862980 TVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 5flo A 1.66 BS02 J4K A 1 Q92 H94 H119 F131 L198 T199 T200 W209 Q90 H92 H117 F128 L195 T196 T197 W206 4.2.1.1 26882437 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5flp A 1.71 BS03 6J5 A 2 F131 V135 L198 P202 L204 F127 V131 L194 P198 L200 4.2.1.1 26882437 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5flr A 1.68 BS02 XCZ A 1 Q92 H94 H96 H119 L198 T199 T200 W209 Q90 H92 H94 H117 L195 T196 T197 W206 4.2.1.1 26882437 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5fls A 1.67 BS02 6ZX A 1 H94 F131 L198 T199 T200 P202 H92 F128 L195 T196 T197 P199 4.2.1.1 26882437 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5flt A 1.67 BS02 VJJ A 1 Q92 H94 F131 L198 T199 T200 P202 Q90 H92 F128 L195 T196 T197 P199 4.2.1.1 26882437 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5fmg I 3.60 BS01 7F1 I 1 T1 A20 T21 A27 C31 S32 K33 G47 A49 L52 S129 T1 A20 T21 A27 C31 S32 K33 G47 A49 L52 S125 3.4.25.1 26863983 TTICGLVCQNAVILGADTRATEGPIVADKNCSKLHYISKNIWCAGAGVAGDLEHTTLWLQHNVELHRLNTNTQPRVSMCVSRLTQELFKYVCAIVLGGVDVNGPQLYGIHPHGSSCLLPFTALGSGSLNAMAVLEAKYRDNMTIEEGKNLVCEAICAGIFNDLGSGGNVDICVITKDSYQHIRPYK 5fmg J 3.60 BS01 7F1 I 1 A136 D138 I140 K143 C144 A113 D115 I117 K120 C121 3.4.25.1 26863983 GCVLGMSGSNCVAIACDLRLGANTFTTVSTKFSKIFKMNNNVYVGLSGLATDIQTLYEILRYRVNLYEVRQDAEMDVECFANMLSSILYSNRFSPYFVNPIVVGFKYEPYLTAYDLIGAKCETRDFVVNGVTSEQLFGMCESLYVKDQDENGLFETISQCLLSALDRDCISGWGAEVLVLTPEKIIKKKLK 5fnh A 1.66 BS02 YIP A 1 H94 H119 L198 T199 T200 P202 W209 H91 H116 L194 T195 T196 P198 W205 4.2.1.1 26882437 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5fni A 1.60 BS02 YIH A 1 Q92 H94 H119 F131 L141 L198 T199 T200 W209 Q90 H92 H117 F128 L138 L195 T196 T197 W206 4.2.1.1 26882437 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5fnj A 1.67 BS03 YI6 A 2 D72 I91 D130 F131 G132 D70 I89 D127 F128 G129 4.2.1.1 26882437 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5foq A 2.30 BS01 GC8 A 1 Y72 D74 W86 G120 G121 Y124 E202 W286 Y337 F338 Y341 Y72 D74 W86 G120 G121 Y124 E202 W279 Y330 F331 Y334 3.1.1.7 26751405 EGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSA 5fp0 A 2.35 BS01 SZC A 1 F267 D335 W336 M339 F381 Y383 Q384 L408 Y466 V498 L499 M503 H524 W525 F266 D334 W335 M338 F377 Y379 Q380 L404 Y462 V494 L495 M499 H520 W521 3.3.2.10,3.1.3.76 26845235 TLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESNPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDAR 5fr9 A 2.81 BS01 9HC A 1 R86 M122 Q155 K188 E221 G222 G224 F225 N226 L243 G245 I246 T247 T283 G284 R75 M111 Q144 K177 E210 G211 G213 F214 N215 L232 G234 I235 T236 T272 G273 2.6.1.18 26836037 YTHDTGLDYITYSDYELDPANPLAGGAAWIEGAFVPPSEARISIFDQGFYTSDATYTTFHVWNGNAFRLGDHIERLFSNAESIRLIPPLTQDEVKEIALELVAKTELREAMVTVTITRGYSSTPFERDITKHRPQVYMSACPYQWIVPFDRIRDGVHLMVAQSVRRTPRSSIDPQVKNFQWGDLIRAIQETHDRGFELPLLLDCDNLLAEGPGFNVVVIKDGVVRSPGRAALPGITRKTVLEIAESLGHEAILADITPAELYDADEVLGCSTGGGVWPFVSVDGNSISDGVPGPVTQSIIRRYWELNVEPSSLLTPVQY 5fr9 C 2.81 BS01 9HC C 1 T69 R86 M122 Q155 I157 K188 E221 G224 F225 N226 L243 G245 I246 T247 T283 G284 T60 R77 M113 Q146 I148 K179 E212 G215 F216 N217 L234 G236 I237 T238 T274 G275 2.6.1.18 26836037 IVYTHDTGLDYITYSDYELDPANPLAGGAAWIEGAFVPPSEARISIFDQGFYTSDATYTTFHVWNGNAFRLGDHIERLFSNAESIRLIPPLTQDEVKEIALELVAKTELREAMVTVTITRGYSSTPFERDITKHRPQVYMSACPYQWIVPFDRIRDGVHLMVAQSVRRTPRSSIDPQVKNFQWGDLIRAIQETHDRGFELPLLLDCDNLLAEGPGFNVVVIKDGVVRSPGRAALPGITRKTVLEIAESLGHEAILADITPAELYDADEVLGCSTGGGVWPFVSVDGNSISDGVPGPVTQSIIRRYWELNVEPSSLLTPVQY 5fr9 D 2.81 BS01 9HC D 1 T69 R86 Q155 K188 E221 G224 F225 N226 L243 G245 I246 T247 T283 G284 T61 R78 Q147 K180 E213 G216 F217 N218 L235 G237 I238 T239 T275 G276 2.6.1.18 26836037 EIVYTHDTGLDYITYSDYELDPANPLAGGAAWIEGAFVPPSEARISIFDQGFYTSDATYTTFHVWNGNAFRLGDHIERLFSNAESIRLIPPLTQDEVKEIALELVAKTELREAMVTVTITRGYSSTPFERDITKHRPQVYMSACPYQWIVPFDRIRDGVHLMVAQSVRRTPRSSIDPQVKNFQWGDLIRAIQETHDRGFELPLLLDCDNLLAEGPGFNVVVIKDGVVRSPGRAALPGITRKTVLEIAESLGHEAILADITPAELYDADEVLGCSTGGGVWPFVSVDGNSISDGVPGPVTQSIIRRYWELNVEPSSLLTPVQY 5fr9 E 2.81 BS01 9HC E 1 Y67 T69 R86 Q155 K188 E221 G224 F225 L243 G245 I246 T247 S282 T283 G284 Y58 T60 R77 Q146 K179 E212 G215 F216 L234 G236 I237 T238 S273 T274 G275 2.6.1.18 26836037 IVYTHDTGLDYITYSDYELDPANPLAGGAAWIEGAFVPPSEARISIFDQGFYTSDATYTTFHVWNGNAFRLGDHIERLFSNAESIRLIPPLTQDEVKEIALELVAKTELREAMVTVTITRGYSSTPFERDITKHRPQVYMSACPYQWIVPFDRIRDGVHLMVAQSVRRTPRSSIDPQVKNFQWGDLIRAIQETHDRGFELPLLLDCDNLLAEGPGFNVVVIKDGVVRSPGRAALPGITRKTVLEIAESLGHEAILADITPAELYDADEVLGCSTGGGVWPFVSVDGNSISDGVPGPVTQSIIRRYWELNVEPSSLLTPVQY 5fr9 F 2.81 BS01 9HC F 1 R86 Q155 K188 E221 G224 F225 L243 G245 I246 T247 T283 G284 R78 Q147 K180 E213 G216 F217 L235 G237 I238 T239 T275 G276 2.6.1.18 26836037 EIVYTHDTGLDYITYSDYELDPANPLAGGAAWIEGAFVPPSEARISIFDQGFYTSDATYTTFHVWNGNAFRLGDHIERLFSNAESIRLIPPLTQDEVKEIALELVAKTELREAMVTVTITRGYSSTPFERDITKHRPQVYMSACPYQWIVPFDRIRDGVHLMVAQSVRRTPRSSIDPQVKNFQWGDLIRAIQETHDRGFELPLLLDCDNLLAEGPGFNVVVIKDGVVRSPGRAALPGITRKTVLEIAESLGHEAILADITPAELYDADEVLGCSTGGGVWPFVSVDGNSISDGVPGPVTQSIIRRYWELNVEPSSLLTPVQY 5fr9 I 2.81 BS01 9HC I 1 R86 Q155 K188 E221 G222 G224 F225 N226 L243 G245 I246 T247 S282 T283 G284 R76 Q145 K178 E211 G212 G214 F215 N216 L233 G235 I236 T237 S272 T273 G274 2.6.1.18 26836037 VYTHDTGLDYITYSDYELDPANPLAGGAAWIEGAFVPPSEARISIFDQGFYTSDATYTTFHVWNGNAFRLGDHIERLFSNAESIRLIPPLTQDEVKEIALELVAKTELREAMVTVTITRGYSSTPFERDITKHRPQVYMSACPYQWIVPFDRIRDGVHLMVAQSVRRTPRSSIDPQVKNFQWGDLIRAIQETHDRGFELPLLLDCDNLLAEGPGFNVVVIKDGVVRSPGRAALPGITRKTVLEIAESLGHEAILADITPAELYDADEVLGCSTGGGVWPFVSVDGNSISDGVPGPVTQSIIRRYWELNVEPSSLLTPVQY 5frp A 2.90 BS01 III C 1 H405 R408 E409 K410 R415 Y457 Y458 I459 N460 I464 N465 K499 K500 S504 A507 F508 R511 K514 W553 H403 R406 E407 K408 R413 Y455 Y456 I457 N458 I462 N463 K497 K498 S502 A505 F506 R509 K512 W551 KGAVTKLKFNSPIISTSDQLISTNELLDRLKALHEELASLDQDNTDLTGLDKYRDALVSRKLLKHKDVGIRAFTACCLSDILRLYAPDAPYTDAQLTDIFKLVLSQFEQLGDQENGYHIQQTYLITKLLEYRSIVLLADLPSSNNLLIELFHIFYDPNKSFPARLFNVIGGILGEVISEFDSVPLEVLRLIFNKFLTYNPNEIPEGLNVTSDCGYEVSLILCDTYSNRMSRHLTKYYSEIIHEATNDDNNSRLLTVVVKLHKLVLRLWETVPELINAVIGFIYHELSSENELFRKEATKLIGQILTSYSDLNFVSTHSDTFKAWISKIADISPDVRVEWTESIPQIIATREDISKELNQALAKTFIDSDPRVRRTSVMIFNKVPVTEIWKNITNKAIYTSLLHLAREKHKEVRELCINTMAKFYSNSLNEIERTYQNKEIWEIIDTIPSTLYNLYYINDLNINEQVDSVIFEYLLPFEPDNDKRVHRLLTVLSHFDKKAFTSFFAFNARQIKISFAISKYIDFSKFLNNQESMSSSQGPIVMNKYNQTLQWLASGLSDSTKAIDALETIKQFNDERIFYLLNACVTNDIPFLTFKNCYNELVSKLQTPSIMPRDIAKVIQILLFRASPIIYNVSNISVLLNLSNNSDAKQLDLKRRILDDISKVNPTLFKDQIRTLK 5frs A 4.07 BS01 III C 1 H405 R408 E409 K410 R415 Y457 Y458 I459 N460 N465 K499 K500 T503 S504 A507 F508 R511 K514 W553 H403 R406 E407 K408 R413 Y455 Y456 I457 N458 N463 K497 K498 T501 S502 A505 F506 R509 K512 W551 KGAVTKLKFNSPIISTSDQLISTNELLDRLKALHEELASLDQDNTDLTGLDKYRDALVSRKLLKHKDVGIRAFTACCLSDILRLYAPDAPYTDAQLTDIFKLVLSQFEQLGDQENGYHIQQTYLITKLLEYRSIVLLADLPSSNNLLIELFHIFYDPNKSFPARLFNVIGGILGEVISEFDSVPLEVLRLIFNKFLTYNPNEIPEGLNVTSDCGYEVSLILCDTYSNRMSRHLTKYYSEIIHEATNDDNNSRLLTVVVKLHKLVLRLWETVPELINAVIGFIYHELSSENELFRKEATKLIGQILTSYSDLNFVSTHSDTFKAWISKIADISPDVRVEWTESIPQIIATREDISKELNQALAKTFIDSDPRVRRTSVMIFNKVPVTEIWKNITNKAIYTSLLHLAREKHKEVRELCINTMAKFYSNSLNEIERTYQNKEIWEIIDTIPSTLYNLYYINDLNINEQVDSVIFEYLLPFEPDNDKRVHRLLTVLSHFDKKAFTSFFAFNARQIKISFAISKYIDFSKFLNNQESMSSSQGPIVMNKYNQTLQWLASGLSDSTKAIDALETIKQFNDERIFYLLNACVTNDIPFLTFKNCYNELVSKLQTPSIMPRDIAKVIQILLFRASPIIYNVSNISVLLNLSNNSDAKQLDLKRRILDDISKVNPTLFKDQIRTLK 5fv0 A 2.91 BS01 ONA A 1 S1002 G1004 Y1005 G1006 K1007 S1008 T1009 D1105 Q1196 I1197 L1199 D1206 S31 G33 Y34 G35 K36 S37 T38 D134 Q225 I226 L228 D235 ANAFPIGLKDESQSDYFYQWLEDGNIGIFGSAGYGKSTTMMTLLLSFAGAYNPAQLHYYIFDFGNSALLPLRQLPHTADYFRLDDEKKIEKFIKFMKEEMEQRKQRFMEKEVSTIKLYNALSEEKLPIIIVALDNFDVVKEEMPDFETQLIQYARDGQSLGIFFIMTATRVSGIRPPLMNNLKTKIVHYFIDSSEKFSLIGRTPYDVDPIPGRALIKKDNAALTQIYLPADGEDDIEVLENVKREMERLKEVYQHIPKPKPIPMLPPRLSMSVFTNTYVQHRASGFIPVGLDEQTVRPVAINMRTDPHCLIVGQSRKGKTNVVKVILESLLVQEPESIGLLDGIDRGLAGYANRDDITYIEAKERLAQWLNEADAVLQQREREYIQAVNENRATTLAWPPVVFVVDSLLRLQQETDSIMQGRIANMMKQYSHLGFHVFVAGNANEFVKGFDALTAELKQIRQAILVTKKSEQSLFALPFTRNEQEIEPGFGYFVVGGKDQKIQIPKVE 5fv0 B 2.91 BS01 ATP B 1 G1004 G1006 K1007 S1008 T1009 N1036 D1105 I1197 L1199 D1206 G36 G38 K39 S40 T41 N68 D112 I204 L206 D213 ANAFPIGLKDEPELSQSDYFYQWLEDGNIGIFGSAGYGKSTTMMTLLLSFAGAYNPAQLHYYIFDFGNSALLPLRQLPHTADYFRLDDEKKIEKFIKFMKEEMLPIIIVALDNFDVVKEEMPDFETQLIQYARDGQSLGIFFIMTATRVSGIRPPLMNNLKTKIVHYFIDSSEKFSLIGRTPYDVDPIPGRALIKKDNAALTQIYLPADGEDDIEVLENVKREMERLKEVYQHIPKPKPIPMLPPLSMSVFTNTYVHRASGFIPVGLDEQTVRPVAINMRTDPHCLIVGQSRKGKTNVVKVILESLLVQEPESIGLLDGIDRGLAGYANRDDITYIERLAQWLNEADAVLQQREREYWPPVVFVVDSLLRLQETMQGRIANMMKQYSHLGFHVFVAGNANEFVGDALTAELKQIRQAILVTKKSEQSLFALPEQEIEPGFGYFVVGGKDQKIQIPKVE 5h8t A 1.21 BS01 RTL A 1 L20 L36 K40 I51 T53 F57 R58 Y60 M62 G76 I77 W106 Q108 L117 M119 L19 L35 K39 I50 T52 F56 R57 Y59 M61 G75 I76 W105 Q107 L116 M118 VDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKVQHHHHHH 5ha1 A 1.35 BS01 RNE A 1 F16 Y19 L20 V25 L29 A33 L36 K40 I51 T53 S55 F57 R58 N59 Y60 M62 G76 I77 W106 Q108 L117 M119 F16 Y19 L20 V25 L29 A33 L36 K40 I51 T53 S55 F57 R58 N59 Y60 M62 G76 I77 W106 Q108 L117 M119 PVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKVQHHHHHH 5hbs A 0.89 BS01 RTL A 1 L20 L29 L36 P38 K40 I51 T53 R58 N59 Y60 M62 G76 I77 W106 Q108 L117 M119 L20 L29 L36 P38 K40 I51 T53 R58 N59 Y60 M62 G76 I77 W106 Q108 L117 M119 PVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKVQHHHHH 5hc7 A 2.05 BS01 DST A 1 I75 D76 W118 A119 L120 S121 N124 R127 R248 R254 S256 I12 D13 W55 A56 L57 S58 N61 R64 R185 R191 S193 DEVTPNHVAIIIDGHRKWAKSRGVTVQEGHQTGVNNWKHIISRASQLGIKLLTIWALSPQNFNRSKMEVDFLMRIYEDFLRSDVKELVTSQQDIQFSAIGDKSRLPEYLQDAISYAEGLSQANKGMHFILAVAYGGREDIVEAARKIAAKVEHGILRPDDIDEATFEQHLMTNITKFPSPDLLIRAAGEQRLSNFFLWQLPFTEFYFTPKLFPDFGEADLLDALASYRCR 5hc7 A 2.05 BS02 DST A 2 D76 G77 H78 R79 K80 H93 R127 D13 G14 H15 R16 K17 H30 R64 DEVTPNHVAIIIDGHRKWAKSRGVTVQEGHQTGVNNWKHIISRASQLGIKLLTIWALSPQNFNRSKMEVDFLMRIYEDFLRSDVKELVTSQQDIQFSAIGDKSRLPEYLQDAISYAEGLSQANKGMHFILAVAYGGREDIVEAARKIAAKVEHGILRPDDIDEATFEQHLMTNITKFPSPDLLIRAAGEQRLSNFFLWQLPFTEFYFTPKLFPDFGEADLLDALASYRCR 5hc8 A 1.87 BS02 61G A 1 H78 H93 A119 N124 R127 L135 Y139 H15 H30 A56 N61 R64 L72 Y76 DEVTPNHVAIIIDGHRKWAKSRGVTVQEGHQTGVNNWKHIISRASQLGIKLLTIWALSPQNFNRSKMEVDFLMRIYEDFLRSDVKELVTSQQDIQFSAIGDKSRLPEYLQDAISYAEGLSQANKGMHFILAVAYGGREDIVEAARKIAAKVEHGILRPDDIDEATFEQHLMTNITKFPSPDLLIRAAGEQRLSNFFLWQLPFTEFYFTPKLFPDFGEADLLDALASYRCRYRGFGE 5hkj A 1.35 BS01 CA A 1 Q90 D356 Y357 Q363 Q89 D350 Y351 Q357 DQPRPAFSAIRRNPPMGGNVVIFDTVITNQEEPYQNHSGRFVCTVPGYYYFTFQVLSQWEICLSIVSSSRGQVRRSLGFCDTTNKGLFQVVSGGMVLQLQQGDQVWVEKDPKKGHIYQGSEADSVFSGFLIFPSAKFQSVFTVTRQTHQPPAPNSLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCVLLYRSGVKVVTFCGHTSKTNQVNSGGVLLRLQVGEEVWLAVNDYYDMVGIQGSDSVFSGFLLFPDGSAKATQKIAFSATRTINVPLRRDQTIRFDHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTGGMVLKLEQGENVFLQATDKNSLLGMEGANSIFSGFLLFPDM 5hmj A 1.30 BS01 BR A 1 H15 T89 V92 H15 T89 V92 3.2.1.17 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 5hqj A 1.55 BS01 64K A 1 K38 F43 D118 N166 R170 S220 Q221 D249 Q269 K14 F19 D94 N142 R146 S196 Q197 D225 Q245 MKDAKDISVAVIPKVAVPFFDDCNKGAKTAADKAGVKYQWVVPQNTQGSTQVQIIEDLISRHVDGIAISVNEPKSVESVMKRAEQSGIKVLTYDSDSPKSGRSMYIGTNNEQAGATMAETMGKALNGQGEVAIITGQLGAVNLNERIAGIKKGLAKYPGIKVVETQGTDDDLARGVSVVETTLRAHPNLKGIFGVSQVGGPAVAKVLNTREFGAMKGKLEVLAFDDLPDTLKGLKDGYIQGIMVQRPVTMGSLAVDHLVAQIQGQEGQPKDIDTGVTVVTKDNMTSYTK 5hsg A 1.30 BS01 MG A 1 D149 K153 D118 K122 GPTYALVQINQQALFFNLMNKGAQDAAKASGKDLVIFNSNDNPVAQNDAIENYIQQGVKGILVAAIDVNGIMPAVKEAAAANIPVIAIDAVLPAGPQAAQVGVDNIEGGRIIGQYFVDYVQKEMGGQARLGIVGALNSAIQNQRQKGFEETLKSNPKITIANVVDGQNVQDKAMTAAENLITGNPDLTAIYATGEPALLGAIAAVENQGRQKDIKVFGWDLTAKAISGIDGGYVTAVLQQDPEKMGAEALNALNSITSGKTVPKTILVPATVVTKANVDSYRPLF 5ht0 A 2.75 BS01 COA A 1 H29 A30 A31 L32 R33 P42 Y62 D94 N95 G96 F97 A159 P160 T163 T165 H26 A27 A28 L29 R30 P39 Y59 D91 N92 G93 F94 A156 P157 T160 T162 RVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGPDDILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIPAFDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIGGEAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLDTMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEFDTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLVPADEIVAFAVDWLERWGRTA 5ht0 A 2.75 BS02 COA B 1 Q66 R93 Q63 R90 RVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGPDDILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIPAFDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIGGEAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLDTMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEFDTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLVPADEIVAFAVDWLERWGRTA 5ht0 B 2.75 BS02 COA B 1 H29 A30 A31 L32 R33 P42 Y62 N95 G96 F97 A159 P160 T163 H27 A28 A29 L30 R31 P40 Y60 N93 G94 F95 A157 P158 T161 SRVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGPDDILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIPAFDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIGGEAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLDTMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEFDTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLVPADEIVAFAVDWLERWGRTA 5ht0 C 2.75 BS01 COA C 1 H29 A30 A31 L32 R33 P42 N95 G96 F97 A159 T163 H27 A28 A29 L30 R31 P40 N93 G94 F95 A157 T161 SRVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGPDDILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIPAFDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIGGEAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLDTMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEFDTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLVPADEIVAFAVDWLERWGRTAR 5ht0 D 2.75 BS02 COA D 1 H29 A30 A31 L32 R33 P42 Y62 N95 F97 P160 T163 H27 A28 A29 L30 R31 P40 Y60 N93 F95 P158 T161 SRVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGPDDILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIPAFDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIGGEAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLDTMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEFDTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLVPADEIVAFAVDWLERWGRTA 5hu6 A 2.90 BS01 HEM A 1 Y43 F44 H59 K62 L84 L87 H88 L92 V94 N98 F99 L102 L137 Y42 F43 H58 K61 L83 L86 H87 L91 V93 N97 F98 L101 L136 25497229 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 5hu6 B 2.90 BS01 HEM B 1 F42 F43 H64 K67 V68 A71 F72 L89 H93 L97 V99 N103 F104 L107 L142 F40 F41 H62 K65 V66 A69 F70 L87 H91 L95 V97 N101 F102 L105 L140 25497229 HLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALA 5hu6 D 2.90 BS01 HEM B 1 K56 S59 K164 R199 Y200 K19 S22 K127 R162 Y163 25497229 GLKTKDEVEKACHLAQQLKEVSITLGVIYRTTERHSVQVEAHKTAIDKHADAVSRAVEALTRVDVALQRLKELGKANDTKAVKIIENITSARENLALFNNETQAVLTARDHVHKHRAAALQGWSDAKEKGDAAAEDVWVLLNAAKKGNGSADAKAAAEKCSRYSSSSTSETELQKAIDAAANVGGLSAHKSKYGDVLNKFKLSNASVGAVRDTSGRGGKHMEKVNNVAKLLKDAEVSLAAAAAEIEEVKNAHETKVQEEM 5hwv A 1.65 BS01 MBN A 1 F46 F79 W85 I114 F128 E146 G147 F5 F38 W44 I73 F87 E105 G106 2.7.13.3 ALYEFVGLLDAHGNVLEVNQVALEGGGITMEEIRGKPFWKARWWQISKKTEATQKRLVETASSGEFVRCDVEILGKSGGREVIAVDFSLLPICNEEGSIVYLLAEGRNITDKKKAEAMLALKNQ 5hwv B 1.65 BS01 MBN B 1 F46 V47 G48 F79 W84 W85 I114 F128 F4 V5 G6 F37 W42 W43 I72 F86 2.7.13.3 LYEFVGLLDAHGNVLEVNQVALEGGGITMEEIRGKPFWKARWWQISKKTEATQKRLVETASSGEFVRCDVEILGKSGGREVIAVDFSLLPICNEEGSIVYLLAEGRNITDKKKAEAMLALKNQEL 5hww A 2.00 BS01 XBZ A 1 F46 V47 G48 V59 F79 W84 W85 I114 F128 A145 E146 G147 F8 V9 G10 V21 F41 W46 W47 I76 F90 A107 E108 G109 2.7.13.3 GAMALYEFVGLLDAHGNVLEVNQVALEGGGITLEEIRGKPFWKARWWQISKKTEATQKRLVETASSGEFVRCDVEILGKSGGREVIAVDFSLLPICNEEGSIVYLLAEGRNITDKKKAEAMLALKNQE 5hx6 A 2.23 BS01 65U A 1 V31 I43 M44 K45 M67 L70 V75 V76 L78 L90 M92 L129 H136 I154 A155 D156 L157 S161 F162 V19 I31 M32 K33 M55 L58 V63 V64 L66 L78 M80 L117 H124 I142 A143 D144 L145 S149 F150 2.7.11.1 26854747 IKMKSSDFLESAELDSGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE 5hx6 B 2.23 BS01 65U B 1 I43 M44 K45 M67 L70 V76 L78 L90 M92 L129 V134 H136 I154 A155 D156 L157 L159 S161 I25 M26 K27 M49 L52 V58 L60 L72 M74 L111 V116 H118 I136 A137 D138 L139 L141 S143 2.7.11.1 26854747 VIKMKSSDFLESVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE 5hzb B 1.55 BS01 GLC A 1 S401 D403 G451 S170 D172 G220 26889023 SKPFTLPILTLGELTNSRFPLPIDVLYTNPNESAIVQCQNGRCTLDGELQGTTQLLPTGICAFRGKVTQQVQDEHRGTHWNMTVTNLNGTPFDPTEDVPAPLGTPDFSGQIYGVISQRNTLPANRAHEAVIATYSPKFTPKLGNIQFSTWETQDVSSGQPTKFTPVGLASVDANSHFDQWTLPSYSGALTLNMNLAPSVAPVFPGECLLFFRSFIPLKGGYGNPAIDCLMPQEWVQHLYQESAPSLSDVALVRYVNPETGRTLFEAKLHRNGFLTVARNSAGPVVAPTNGYFRFDSWVNQFYTLAPM 5i1f A 2.15 BS01 UPG A 1 P10 A12 G13 K27 E28 Q105 A108 L109 G110 L111 A114 L131 D133 D134 Y171 G172 E191 K192 V204 T232 P11 A13 G14 K28 E29 Q106 A109 L110 G111 L112 A115 L132 D134 D135 Y172 G173 E192 K193 V205 T233 2.7.7.9 HMLKVTKAVFPVAGLGTRFLPATKASPKEMLPVVDKPLIQYAVEEAIEAGITEMIFVTGRSKRAIEDHFDKSYEIEAELEARGKEKLLSLVRSIKPSHVDCFYVRQAEALGLGHAVLCAEKLVGDNPFAVILADDLLDGPTPVLRQMIDVFDHYHASVIGVEEIAPADSKSYGVIDGKRWEDDLFKLSGIVEKPEPAQAPSNFGVVGRYVLKPKIFKHLRGLKPGAGGELQLTDAIQSLLTDEQVLAYRYDGTRFDCGSKLGYLKATVEFALRHPEVAADFERYLLARMS 5i2h A 1.55 BS01 AGI A 1 L158 R165 N267 H270 D271 Y314 L321 L136 R143 N241 H244 D245 Y288 L295 MAVKDALRFPPTDVTPIFDLFRGNFATELLAASVAHLHVFDILNESPLSLDELQRRLVLSERATQVLVTGLCAMQLLTKRAGEIDLTPLARNHLVTTSPFSVGGYISLAAQSAGTLALVERLKSDAMDREDSARFLTLSLAGRAWNVAPRFADVLPAGQPGKILKSSGRVLLDVAGGSGIYTMAVLQKYPTWRGIIFDRPEVLKIAAELAEQTGVRDRLELHAGDMWVDPFPPADDILLSNVLHDWDRPQCARLVAKATSGLPEGGRLLIHDVLLNSDLTGPLEIALYSLALFSLTEGRAYSLEEYRGWIAGADLKYVDCIPTSAHGHLILSEKV 5i4m A 1.80 BS01 ZN A 1 H96 D107 H203 H85 D96 H192 3.5.1.87 ALDTSIKVDGRRLWDSLMEVAKIGATPKGGVCRLALTDLDKAARDLIVGWAKAAGCTVTVDTMGNVFMRRAGRVADAAPVVTGSHADSQPTGGRFDGIYGVLGGLEVIRSLNDHGIETEHPVEVVIWTNEEGSRFAPAMVASGVFAGVFPLEYGLSRKDVDGKTIGEELARIGYAGDAPCGGRKLHAAFELHIEQGPILEAECKTIGVVTDAQGQRWYEITFTGQEAHAGPTPMPRRRDALLGASRVVDLVNRIGLDHAPYGCATVGMMQVHPNSRNVIPGRVFFTVDFRHPDDAVLAKMDAALRDGVARIAADIGLDTALEQIFYYAPIAFDSACVAAVRAAADRFGYSHRDIVSGAGHDACYLAQVAPTSMVFVPCIDGISHNEIEDATPAWIEAGANVLLHAMLSRACEPV 5i4m A 1.80 BS02 ZN A 2 D107 E142 H395 D96 E131 H384 3.5.1.87 ALDTSIKVDGRRLWDSLMEVAKIGATPKGGVCRLALTDLDKAARDLIVGWAKAAGCTVTVDTMGNVFMRRAGRVADAAPVVTGSHADSQPTGGRFDGIYGVLGGLEVIRSLNDHGIETEHPVEVVIWTNEEGSRFAPAMVASGVFAGVFPLEYGLSRKDVDGKTIGEELARIGYAGDAPCGGRKLHAAFELHIEQGPILEAECKTIGVVTDAQGQRWYEITFTGQEAHAGPTPMPRRRDALLGASRVVDLVNRIGLDHAPYGCATVGMMQVHPNSRNVIPGRVFFTVDFRHPDDAVLAKMDAALRDGVARIAADIGLDTALEQIFYYAPIAFDSACVAAVRAAADRFGYSHRDIVSGAGHDACYLAQVAPTSMVFVPCIDGISHNEIEDATPAWIEAGANVLLHAMLSRACEPV 5i5m A 1.37 BS01 CA A 1 Y252 E255 M263 I264 D269 S316 Y198 E201 M209 I210 D215 S262 1.7.2.4 26885878 SAVVHPGELDEYYGFWSGGHSGEVRILGIPSMRELMRIPVFNIDSATGWGITNESKRIKGDSAHLMTGDSHHPHMSMTDGSYNGKYVFINDKANSRVARIRCDVMKTDKMITIPNVQAIHGLRVQKVPYTKYVICNGEFEIPMNNDGKASLEDVSTYRSLFNVIDAEKMEVAFQVMVDGNLDNTDADYDGKYFFSTCYNSEMGMNLGEMITAERDHVVVFSLERCLAALKAGKFTNYNGNKVPVLDGRKGSDLTRYIPVPKSPHGINTAPDGKYFVANGKLSPTVSVVEIARLDDVFSGKIQPRDAIVAEPELGLGPLHTAFDNKGNAFTTLFLDSQIAKWNIQDAIKAYNGEKVNYLRQKLDVHYQPGHNHTSQGETRDTDGKWLVVLCKFSKDRFLPVGPLRPENDQLIDISGDEMKLVHDGPTFAEPHDCMIVHRSKVKPQKLWTRDDPMFADTVAMAKQDGVTLEMDNKVIRDGNKVRVYMTSIAPNFGMNEFKVKLGDEVTVVVTNLDQVEDVTHGFCMTNHGVQMEVAPQATASVTFIANKPGVQWYYCNWFCHALHMEMRGRMLVEAL 5i5m A 1.37 BS02 BU3 A 1 A266 E267 R268 A212 E213 R214 1.7.2.4 26885878 SAVVHPGELDEYYGFWSGGHSGEVRILGIPSMRELMRIPVFNIDSATGWGITNESKRIKGDSAHLMTGDSHHPHMSMTDGSYNGKYVFINDKANSRVARIRCDVMKTDKMITIPNVQAIHGLRVQKVPYTKYVICNGEFEIPMNNDGKASLEDVSTYRSLFNVIDAEKMEVAFQVMVDGNLDNTDADYDGKYFFSTCYNSEMGMNLGEMITAERDHVVVFSLERCLAALKAGKFTNYNGNKVPVLDGRKGSDLTRYIPVPKSPHGINTAPDGKYFVANGKLSPTVSVVEIARLDDVFSGKIQPRDAIVAEPELGLGPLHTAFDNKGNAFTTLFLDSQIAKWNIQDAIKAYNGEKVNYLRQKLDVHYQPGHNHTSQGETRDTDGKWLVVLCKFSKDRFLPVGPLRPENDQLIDISGDEMKLVHDGPTFAEPHDCMIVHRSKVKPQKLWTRDDPMFADTVAMAKQDGVTLEMDNKVIRDGNKVRVYMTSIAPNFGMNEFKVKLGDEVTVVVTNLDQVEDVTHGFCMTNHGVQMEVAPQATASVTFIANKPGVQWYYCNWFCHALHMEMRGRMLVEAL 5i5m A 1.37 BS03 BU3 A 2 S130 N137 K139 Y140 Y183 T184 E221 S76 N83 K85 Y86 Y129 T130 E167 1.7.2.4 26885878 SAVVHPGELDEYYGFWSGGHSGEVRILGIPSMRELMRIPVFNIDSATGWGITNESKRIKGDSAHLMTGDSHHPHMSMTDGSYNGKYVFINDKANSRVARIRCDVMKTDKMITIPNVQAIHGLRVQKVPYTKYVICNGEFEIPMNNDGKASLEDVSTYRSLFNVIDAEKMEVAFQVMVDGNLDNTDADYDGKYFFSTCYNSEMGMNLGEMITAERDHVVVFSLERCLAALKAGKFTNYNGNKVPVLDGRKGSDLTRYIPVPKSPHGINTAPDGKYFVANGKLSPTVSVVEIARLDDVFSGKIQPRDAIVAEPELGLGPLHTAFDNKGNAFTTLFLDSQIAKWNIQDAIKAYNGEKVNYLRQKLDVHYQPGHNHTSQGETRDTDGKWLVVLCKFSKDRFLPVGPLRPENDQLIDISGDEMKLVHDGPTFAEPHDCMIVHRSKVKPQKLWTRDDPMFADTVAMAKQDGVTLEMDNKVIRDGNKVRVYMTSIAPNFGMNEFKVKLGDEVTVVVTNLDQVEDVTHGFCMTNHGVQMEVAPQATASVTFIANKPGVQWYYCNWFCHALHMEMRGRMLVEAL 5i5m A 1.37 BS04 BU3 A 3 I105 H581 T596 F597 I51 H527 T542 F543 1.7.2.4 26885878 SAVVHPGELDEYYGFWSGGHSGEVRILGIPSMRELMRIPVFNIDSATGWGITNESKRIKGDSAHLMTGDSHHPHMSMTDGSYNGKYVFINDKANSRVARIRCDVMKTDKMITIPNVQAIHGLRVQKVPYTKYVICNGEFEIPMNNDGKASLEDVSTYRSLFNVIDAEKMEVAFQVMVDGNLDNTDADYDGKYFFSTCYNSEMGMNLGEMITAERDHVVVFSLERCLAALKAGKFTNYNGNKVPVLDGRKGSDLTRYIPVPKSPHGINTAPDGKYFVANGKLSPTVSVVEIARLDDVFSGKIQPRDAIVAEPELGLGPLHTAFDNKGNAFTTLFLDSQIAKWNIQDAIKAYNGEKVNYLRQKLDVHYQPGHNHTSQGETRDTDGKWLVVLCKFSKDRFLPVGPLRPENDQLIDISGDEMKLVHDGPTFAEPHDCMIVHRSKVKPQKLWTRDDPMFADTVAMAKQDGVTLEMDNKVIRDGNKVRVYMTSIAPNFGMNEFKVKLGDEVTVVVTNLDQVEDVTHGFCMTNHGVQMEVAPQATASVTFIANKPGVQWYYCNWFCHALHMEMRGRMLVEAL 5i5m A 1.37 BS05 BU3 A 4 Q429 K494 Q375 K440 1.7.2.4 26885878 SAVVHPGELDEYYGFWSGGHSGEVRILGIPSMRELMRIPVFNIDSATGWGITNESKRIKGDSAHLMTGDSHHPHMSMTDGSYNGKYVFINDKANSRVARIRCDVMKTDKMITIPNVQAIHGLRVQKVPYTKYVICNGEFEIPMNNDGKASLEDVSTYRSLFNVIDAEKMEVAFQVMVDGNLDNTDADYDGKYFFSTCYNSEMGMNLGEMITAERDHVVVFSLERCLAALKAGKFTNYNGNKVPVLDGRKGSDLTRYIPVPKSPHGINTAPDGKYFVANGKLSPTVSVVEIARLDDVFSGKIQPRDAIVAEPELGLGPLHTAFDNKGNAFTTLFLDSQIAKWNIQDAIKAYNGEKVNYLRQKLDVHYQPGHNHTSQGETRDTDGKWLVVLCKFSKDRFLPVGPLRPENDQLIDISGDEMKLVHDGPTFAEPHDCMIVHRSKVKPQKLWTRDDPMFADTVAMAKQDGVTLEMDNKVIRDGNKVRVYMTSIAPNFGMNEFKVKLGDEVTVVVTNLDQVEDVTHGFCMTNHGVQMEVAPQATASVTFIANKPGVQWYYCNWFCHALHMEMRGRMLVEAL 5i5m B 1.37 BS01 CA B 1 Y252 E255 M263 D269 S316 Y199 E202 M210 D216 S263 1.7.2.4 26885878 ASAVVHPGELDEYYGFWSGGHSGEVRILGIPSMRELMRIPVFNIDSATGWGITNESKRIKGDSAHLMTGDSHHPHMSMTDGSYNGKYVFINDKANSRVARIRCDVMKTDKMITIPNVQAIHGLRVQKVPYTKYVICNGEFEIPMNNDGKASLEDVSTYRSLFNVIDAEKMEVAFQVMVDGNLDNTDADYDGKYFFSTCYNSEMGMNLGEMITAERDHVVVFSLERCLAALKAGKFTNYNGNKVPVLDGRKGSDLTRYIPVPKSPHGINTAPDGKYFVANGKLSPTVSVVEIARLDDVFSGKIQPRDAIVAEPELGLGPLHTAFDNKGNAFTTLFLDSQIAKWNIQDAIKAYNGEKVNYLRQKLDVHYQPGHNHTSQGETRDTDGKWLVVLCKFSKDRFLPVGPLRPENDQLIDISGDEMKLVHDGPTFAEPHDCMIVHRSKVKPQKLWTRDDPMFADTVAMAKQDGVTLEMDNKVIRDGNKVRVYMTSIAPNFGMNEFKVKLGDEVTVVVTNLDQVEDVTHGFCMTNHGVQMEVAPQATASVTFIANKPGVQWYYCNWFCHALHMEMRGRMLVEAL 5ic2 A 2.10 BS01 PBG A 1 F79 C120 C122 S165 K195 Y201 F204 R205 R216 Q220 K247 Y270 V272 S273 Y312 F78 C119 C121 S164 K194 Y200 F203 R204 R215 Q219 K246 Y269 V271 S272 Y311 4.2.1.24 TDLIQRPRRLRKSPALRAMFEETTLSLNDLVLPIFVEEEIDDYKAVEAMPGVMRIPEKHLAREIERIANAGIRSVMTFGISHHTDETGSDAWREDGLVARMSRICKQTVPEMIVMSDTCFCEYTSHGHCGVLCEHGVDNDATLENLGKQAVVAAAAGADFIAPSAAMDGQVQAIRQALDAAGFKDTAIMSYSTKFASSFYGPFREAAGSALKGDRKSYQMNPMNRREAIRESLLDEAQGADCLMVKPAGAYLDIVRELRERTELPIGAYQVSGEYAMIKFAALAGAIDEEKVVLESLGSIKRAGADLIFSYFALDLAEKKILR