3wxb A 1.98 BS01 NDP A 1 G13 N15 R16 G17 I18 R41 R47 L66 E67 V68 N96 A97 G98 I99 I157 S158 S159 Y178 K182 H207 P208 G209 W210 V211 T213 M215 G23 N25 R26 G27 I28 R51 R57 L76 E77 V78 N106 A107 G108 I109 I167 S168 S169 Y188 K192 H217 P218 G219 W220 V221 T223 M225 1.1.1.184 SSGLVPRGSHMGELRVRSVLVTGANRGIGLGFVQHLLALSNPPEWVFATCRDPKGQRAQELQKLASKHPNLVIVPLEVTDPASIKAAAASVGERLKGSGLNLLINNAGIARANTIDNETLKDMSEVYTTNTIAPLLLSQAFLPMLKKAAQENPGSGLSCSKAAIINISSTAGSIQDLYLWQYGQALSYRCSKAALNMLTRCQSMGYREHGIFCVALHPGWVKTDMGGTLEDKSRVTVDESVGGMLKVLSNLSEKDSGAFLNWEGKVMAW 3wxb B 1.98 BS01 NDP B 1 G13 N15 R16 G17 I18 R41 L66 E67 V68 N96 A97 G98 I99 I157 S158 S159 Y178 K182 P208 G209 W210 V211 T213 M215 G216 G10 N12 R13 G14 I15 R38 L63 E64 V65 N93 A94 G95 I96 I150 S151 S152 Y171 K175 P201 G202 W203 V204 T206 M208 G209 1.1.1.184 LRVRSVLVTGANRGIGLGFVQHLLALSNPPEWVFATCRDPKGQRAQELQKLASKHPNLVIVPLEVTDPASIKAAAASVGERLKGSGLNLLINNAGIARANTIDNETLKDMSEVYTTNTIAPLLLSQAFLPMLKKAAQEGLSCSKAAIINISSTAGSIQDLYLWQYGQALSYRCSKAALNMLTRCQSMGYREHGIFCVALHPGWVKTDMGGTLEDKSRVTVDESVGGMLKVLSNLSEKDSGAFLNWEGKVMAW 3x43 A 2.25 BS01 PLP A 1 K43 N73 F176 G177 T178 T179 T181 Q220 G221 L222 S265 P291 D292 Y297 K42 N72 F175 G176 T177 T178 T180 Q219 G220 L221 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLAS 3x43 B 2.25 BS01 PLP B 1 K43 N73 F176 G177 T178 T179 T181 Q220 G221 L222 S265 P291 D292 Y297 K42 N72 F175 G176 T177 T178 T180 Q219 G220 L221 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLASLDT 3x43 C 2.25 BS01 PLP C 1 K43 N73 F176 G177 T178 T179 T181 Q220 L222 S265 P291 D292 Y297 K42 N72 F175 G176 T177 T178 T180 Q219 L221 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLASL 3x43 D 2.25 BS01 PLP D 1 K43 N73 F176 G177 T178 T179 G180 T181 Q220 G221 L222 S265 P291 D292 Y297 K42 N72 F175 G176 T177 T178 G179 T180 Q219 G220 L221 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLAS 3x43 E 2.25 BS01 PLP E 1 K43 N73 F176 G177 T178 T179 G180 T181 Q220 G221 L222 S265 P291 D292 Y297 K42 N72 F175 G176 T177 T178 G179 T180 Q219 G220 L221 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLASL 3x43 F 2.25 BS01 PLP F 1 K43 N73 F176 G177 T178 T179 T181 Q220 G221 L222 S265 P291 D292 Y297 K42 N72 F175 G176 T177 T178 T180 Q219 G220 L221 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLAS 3x43 G 2.25 BS01 PLP G 1 K43 N73 F176 G177 T178 T179 G180 T181 Q220 G221 L222 S265 P291 D292 Y297 K42 N72 F175 G176 T177 T178 G179 T180 Q219 G220 L221 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLASL 3x43 H 2.25 BS01 PLP H 1 K43 N73 F176 G177 T178 T179 G180 T181 Q220 G221 L222 S265 P291 D292 Y297 K42 N72 F175 G176 T177 T178 G179 T180 Q219 G220 L221 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLAS 3x44 A 1.90 BS01 PUS A 1 T70 S71 N73 V74 S121 Q142 F143 F176 G177 T178 T179 T181 Q220 G221 L222 P224 S265 P291 D292 Y297 T69 S70 N72 V73 S120 Q141 F142 F175 G176 T177 T178 T180 Q219 G220 L221 P223 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVADRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLASLDTGS 3x44 B 1.90 BS01 PUS B 1 T70 S71 N73 V74 S121 Q142 F143 F176 G177 T178 T179 G180 T181 Q220 G221 L222 P224 S265 P291 D292 Y297 T69 S70 N72 V73 S120 Q141 F142 F175 G176 T177 T178 G179 T180 Q219 G220 L221 P223 S264 P290 D291 Y296 2.6.99.3,2.5.1.47 PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVADRLALSVVLDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTFLFDGVDEGSDDAWLAS 4ph7 A 2.55 BS01 2Y5 A 1 L64 T65 R66 I67 T68 L69 I73 M79 Q86 W117 V124 K125 K126 N129 H157 H158 Y164 P181 S183 S190 A191 A192 T198 Q219 V222 V224 I227 I234 K351 E355 R359 L30 T31 R32 I33 T34 L35 I39 M45 Q52 W83 V90 K91 K92 N95 H123 H124 Y130 P147 S149 S156 A157 A158 T164 Q185 V188 V190 I193 I200 K317 E321 R325 IDTDDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTNQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEYFTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIELGDHMIIKSPNFQADIEFKTKGYVFGTYDAIEGTVKDYDGNAYYEISGKWNDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKKVTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGEDLDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQK 4ph7 B 2.55 BS01 2Y5 B 1 L64 T65 R66 I67 T68 L69 I73 M79 R82 Q86 Y113 V124 K126 N129 H157 H158 Y164 P181 S183 S190 A191 A192 M194 T198 V222 V224 I227 I234 K351 E355 R359 L30 T31 R32 I33 T34 L35 I39 M45 R48 Q52 Y79 V90 K92 N95 H123 H124 Y130 P147 S149 S156 A157 A158 M160 T164 V188 V190 I193 I200 K312 E316 R320 IDTDDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTNQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEYFTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIELGDHMIIKSPNFQADIEFKTKTYDAIEGTVKDYDGNAYYEISGKWNDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKKVTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGEDLDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQ 4ph7 C 2.55 BS01 2Y5 C 1 I55 L64 T65 R66 I67 T68 L69 M79 R82 Q86 Y113 W117 V124 K125 K126 N129 H157 H158 Y164 S183 A192 M194 T198 V222 V224 M232 I234 K351 E355 R359 I17 L26 T27 R28 I29 T30 L31 M41 R44 Q48 Y75 W79 V86 K87 K88 N91 H119 H120 Y126 S145 A154 M156 T160 V184 V186 M194 I196 K313 E317 R321 DTDDIDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTNQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEYFTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIELGDHMIIKSPNFQADIEFKTKGYVFGTYDAIEGTVKDYDGNAYYEISGKWNDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKKVTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGEDLDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKS 4ph7 D 2.55 BS01 2Y5 D 1 I51 L64 T65 R66 I67 T68 L69 I73 M79 R82 V83 Q86 W117 V124 K125 K126 P127 N129 H157 H158 Y164 P181 S183 S190 A192 M194 T198 V222 V224 I227 M232 I234 K351 E355 R359 I16 L29 T30 R31 I32 T33 L34 I38 M44 R47 V48 Q51 W82 V89 K90 K91 P92 N94 H122 H123 Y129 P146 S148 S155 A157 M159 T163 V187 V189 I192 M197 I199 K316 E320 R324 DTDDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTNQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEYFTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIELGDHMIIKSPNFQADIEFKTKGYVFGTYDAIEGTVKDYDGNAYYEISGKWNDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKKVTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGEDLDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQKKMIENEK 4qi1 A 1.85 BS01 RET A 1 Y91 W94 T97 T98 L101 M126 W146 S149 T150 M153 W190 Y193 W197 A223 K224 Y81 W84 T87 T88 L91 M116 W136 S139 T140 M143 W180 Y183 W187 A213 K214 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 A 1.85 BS02 MPG A 1 F96 L103 Q113 I116 A124 F86 L93 Q103 I106 A114 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 A 1.85 BS03 MPG A 2 M31 I35 G38 L39 K47 V51 I54 L55 A58 A61 M21 I25 G28 L29 K37 V41 I44 L45 A48 A51 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 A 1.85 BS04 MPG A 3 R114 D115 G117 A118 G121 A124 V128 R104 D105 G107 A108 G111 A114 V118 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 A 1.85 BS05 MPG B 1 F71 F96 F61 F86 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 B 1.85 BS01 MPG A 4 I122 F125 S152 Y159 I112 F115 S142 Y149 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 B 1.85 BS02 RET B 1 Y91 W94 T97 T98 L101 M126 W146 S149 T150 W190 Y193 P194 W197 A223 K224 Y81 W84 T87 T88 L91 M116 W136 S139 T140 W180 Y183 P184 W187 A213 K214 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 B 1.85 BS03 MPG B 2 E48 V51 I52 L55 I59 A62 A89 E38 V41 I42 L45 I49 A52 A79 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 B 1.85 BS04 MPG B 1 T74 W88 L95 L131 L135 K137 T64 W78 L85 L121 L125 K127 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 B 1.85 BS05 MPG B 3 T147 V154 F155 Y158 T137 V144 F145 Y148 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 B 1.85 BS06 MPG B 4 V154 L157 Y158 V161 E166 V144 L147 Y148 V151 E156 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 B 1.85 BS07 MPG B 5 T24 M31 G38 L39 I54 L55 A61 T14 M21 G28 L29 I44 L45 A51 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 C 1.85 BS01 MPG A 5 K47 E48 V51 I52 L55 I59 A62 L100 K37 E38 V41 I42 L45 I49 A52 L90 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 C 1.85 BS02 MPG B 6 R114 G117 G121 A124 V128 V132 R104 G107 G111 A114 V118 V122 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 C 1.85 BS03 MPG B 7 I122 F125 I151 Y159 I112 F115 I141 Y149 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 C 1.85 BS04 RET C 1 Y91 W94 T98 L101 M126 W146 S149 T150 M153 W190 Y193 P194 W197 D220 A223 K224 Y81 W84 T88 L91 M116 W136 S139 T140 M143 W180 Y183 P184 W187 D210 A213 K214 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qi1 C 1.85 BS05 MPG C 1 F96 P99 S112 Q113 R114 I116 V120 F86 P89 S102 Q103 R104 I106 V110 LGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIM 4qid A 2.57 BS01 RET A 1 Y91 W94 T98 L101 M126 G130 W146 S149 T150 M153 W190 Y193 P194 A223 K224 Y80 W83 T87 L90 M115 G119 W135 S138 T139 M142 W179 Y182 P183 A212 K213 GVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIMG 4qid B 2.57 BS01 RET B 1 Y91 W94 T97 T98 L101 G130 W146 S149 T150 M153 W190 Y193 P194 W197 K224 Y78 W81 T84 T85 L88 G117 W133 S136 T137 M140 W177 Y180 P181 W184 K211 EGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAI 4qid B 2.57 BS02 MPG B 1 E173 R176 S177 N180 A181 N184 I230 E160 R163 S164 N167 A168 N171 I217 EGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAI 4qo9 A 2.20 BS01 627 A 1 I30 A51 K53 M99 E100 Y101 L102 G103 G104 G105 A148 N149 L151 Y291 I13 A34 K36 M82 E83 Y84 L85 G86 G87 G88 A131 N132 L134 Y274 2.7.11.1 ADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQ 4qo9 B 2.20 BS01 627 B 1 I30 F35 A51 K53 M99 E100 Y101 L102 G103 G104 G105 A148 L151 A161 I288 Y291 K292 I18 F23 A39 K41 M87 E88 Y89 L90 G91 G92 G93 A136 L139 A149 I276 Y279 K280 2.7.11.1 MQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQ 4qr7 A 2.30 BS01 MLD A 1 L62 T63 A64 S65 S80 R139 Q140 L4 T5 A6 S7 S22 R81 Q82 VPKLTASVTDGAVGVTVDAPVSVTAADGVLAAVTMVNDNGRPVAGRLSPDGLRWSTTEQLGYNRRYTLNATALGLGGAATRQLTFQTSSPAHLTMPYVMPGDGEVVGVGEPVAIRFDENIADRGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKPGTAVDVAVNTYGVDLGEGMFGEDNVQTHFTIGDEVIATADDNTKILTVRVNGEVVKSMPTSMGKDSTPTANGIYIVGSRYKHIIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVFVHSAPWSVGAQGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNTVGGTLPGIDGLGDWNIPWDQWRAGNAK 4qr7 A 2.30 BS02 DWZ A 1 M303 Y308 Y318 G332 H352 C354 M245 Y250 Y260 G274 H294 C296 VPKLTASVTDGAVGVTVDAPVSVTAADGVLAAVTMVNDNGRPVAGRLSPDGLRWSTTEQLGYNRRYTLNATALGLGGAATRQLTFQTSSPAHLTMPYVMPGDGEVVGVGEPVAIRFDENIADRGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKPGTAVDVAVNTYGVDLGEGMFGEDNVQTHFTIGDEVIATADDNTKILTVRVNGEVVKSMPTSMGKDSTPTANGIYIVGSRYKHIIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVFVHSAPWSVGAQGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNTVGGTLPGIDGLGDWNIPWDQWRAGNAK 4qrd A 1.97 BS01 3BJ A 1 P11 I12 Y14 D51 H53 G54 T133 Y235 V236 W237 A240 L241 N243 Y244 I273 F276 H277 P10 I11 Y13 D50 H52 G53 T132 Y234 V235 W236 A239 L240 N242 Y243 I272 F275 H276 6.1.1.10 AKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFP 4qre A 1.70 BS01 3BG A 1 P11 I12 Y14 D51 H53 G54 T133 Y134 F220 V234 Y235 V236 W237 D239 A240 N243 Y244 I273 F276 P10 I11 Y13 D50 H52 G53 T132 Y133 F219 V233 Y234 V235 W236 D238 A239 N242 Y243 I272 F275 6.1.1.10 AKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFP 4qre A 1.70 BS02 ATP A 1 P11 Y13 H20 G22 H23 S26 A270 E272 I273 H299 G300 W301 I302 K308 M309 S310 K311 P10 Y12 H19 G21 H22 S25 A269 E271 I272 H298 G299 W300 I301 K307 M308 S309 K310 6.1.1.10 AKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFP 4qtf A 2.00 BS01 MLD A 1 L62 T63 A64 S65 T67 S80 R139 L4 T5 A6 S7 T9 S22 R81 VPKLTASVTDGAVGVTVDAPVSVTAADGVLAAVTMVNDNGRPVAGRLSPDGLRWSTTEQLGYNRRYTLNATALGLGGAATRQLTFQTSSPAHLTMPYVMPGDGEVVGVGEPVAIRFDENIADRGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKPGTAVDVAVNTYGVDLGEGMFGEDNVQTHFTIGDEVIATADDNTKILTVRVNGEVVKSMPTSMGKDSTPTANGIYIVGSRYKHIIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVFVHSAPWSVGAQGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNTVGGTLPGIDGLGDWNIPWDQWRAGNAK 4qtf A 2.00 BS02 3V5 A 1 M303 S331 G332 F334 H336 H352 G353 C354 M245 S273 G274 F276 H278 H294 G295 C296 VPKLTASVTDGAVGVTVDAPVSVTAADGVLAAVTMVNDNGRPVAGRLSPDGLRWSTTEQLGYNRRYTLNATALGLGGAATRQLTFQTSSPAHLTMPYVMPGDGEVVGVGEPVAIRFDENIADRGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKPGTAVDVAVNTYGVDLGEGMFGEDNVQTHFTIGDEVIATADDNTKILTVRVNGEVVKSMPTSMGKDSTPTANGIYIVGSRYKHIIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVFVHSAPWSVGAQGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNTVGGTLPGIDGLGDWNIPWDQWRAGNAK 4qtr A 3.20 BS01 NUC E 1 T6 W48 T2 W44 RTAFSEEQKKALDLAFYFDRYLTPEWRRYLSQRLGLNEAQIKIWFQNKRAKIKKS 4qtr A 3.20 BS02 NUC F 1 R5 Y25 R53 R1 Y21 R49 RTAFSEEQKKALDLAFYFDRYLTPEWRRYLSQRLGLNEAQIKIWFQNKRAKIKKS 4qtr B 3.20 BS01 NUC E 1 T6 F8 Q44 I47 N51 T1 F3 Q39 I42 N46 TAFSEEQKKALDLAFYFDRYLTPEWRRYLSQRLGLNEAQIKIWFQNKRAKIKKS 4qtr B 3.20 BS02 NUC F 1 Y25 R31 R53 Y20 R26 R48 TAFSEEQKKALDLAFYFDRYLTPEWRRYLSQRLGLNEAQIKIWFQNKRAKIKKS 4qtr C 3.20 BS01 NUC G 1 R5 T6 F8 Q44 I47 W48 N51 R1 T2 F4 Q40 I43 W44 N47 RTAFSEEQKKALDLAFYFDRYLTPEWRRYLSQRLGLNEAQIKIWFQNKRAKIKKSTG 4qtr C 3.20 BS02 NUC H 1 Y25 R31 Y21 R27 RTAFSEEQKKALDLAFYFDRYLTPEWRRYLSQRLGLNEAQIKIWFQNKRAKIKKSTG 4qtr D 3.20 BS01 NUC H 1 T6 I47 W48 N51 T2 I43 W44 N47 RTAFSEEQKKALDLAFYFDRYLTPEWRRYLSQRLGLNEAQIKIWFQNKRAKIKKS 4qzj A 1.95 BS01 HEM A 1 G104 L105 I107 R108 W111 V239 P241 L274 I275 G278 H279 G282 K283 T284 H285 T323 S324 W330 L386 T388 F416 W420 G69 L70 I72 R73 W76 V204 P206 L239 I240 G243 H244 G247 K248 T249 H250 T288 S289 W295 L351 T353 F381 W385 1.11.1.21 GTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAVKRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDVYWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPEGPDGNPDPVAAARDIRDTFARMAMNDEETVALIAGGHTFGKTHGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGADAITSGLEVTWTTTPTQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKKHRPTMLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARYLGPEVPAEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTAWAAASTFRGSDKRGGANGARIRLAPQKDWEANQPEQLAAVLETLEAIRTAFNGAQRGGKQVSLADLIVLAGCAGVEQAAKNAGHAVTVPFAPGRADASQEQTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDKAQLLTLSAPEMTVLLGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAADADVFEGRDRATGELKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVAVWNKVMNLDRFDLA 4qzj B 1.95 BS01 HEM B 1 G104 L105 I107 R108 W111 V239 P241 L274 I275 G278 H279 G282 K283 T284 H285 T323 S324 W330 L386 T388 W420 G69 L70 I72 R73 W76 V204 P206 L239 I240 G243 H244 G247 K248 T249 H250 T288 S289 W295 L351 T353 W385 1.11.1.21 GTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAVKRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDVYWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPEGPDGNPDPVAAARDIRDTFARMAMNDEETVALIAGGHTFGKTHGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGADAITSGLEVTWTTTPTQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKKHRPTMLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARYLGPEVPAEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTAWAAASTFRGSDKRGGANGARIRLAPQKDWEANQPEQLAAVLETLEAIRTAFNGAQRGGKQVSLADLIVLAGCAGVEQAAKNAGHAVTVPFAPGRADASQEQTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDKAQLLTLSAPEMTVLLGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAADADVFEGRDRATGELKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVAVWNKVMNLDRFDLA 4rav B 2.50 BS01 III E 1 F220 A221 N222 G224 P225 F93 A94 N95 G97 P98 25861763 QSALTQPASVSGSPGQSITISCTGTSSDIGAYNYVSWYQQYPGKAPKLLIYDVSNRPSGISNRFSGSKSGDTASLTISGLQAEDEADYYCSSFANSGPLFGGGTKVTVLG 4rav B 2.50 BS02 III F 1 Y161 F220 Y34 F93 25861763 QSALTQPASVSGSPGQSITISCTGTSSDIGAYNYVSWYQQYPGKAPKLLIYDVSNRPSGISNRFSGSKSGDTASLTISGLQAEDEADYYCSSFANSGPLFGGGTKVTVLG 4rav A 2.50 BS01 III E 1 S31 Y32 S33 S35 V50 I51 S52 Y53 N57 K58 Y59 D99 R100 S31 Y32 S33 S35 V50 I51 S52 Y53 N57 K58 Y59 D99 R100 25861763 QVQLQESGGGLVQPGGSLRLSCAASGFTFSSYSMSWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDRYFDLWGRGTLVTVSSGGG 4rav D 2.50 BS01 III E 1 Y161 F220 Y35 F94 25861763 SQSALTQPASVSGSPGQSITISCTGTSSDIGAYNYVSWYQQYPGKAPKLLIYDVSNRPSGISNRFSGSKSGDTASLTISGLQAEDEADYYCSSFANSGPLFGGGTKVTVL 4rav D 2.50 BS02 III F 1 F220 A221 N222 S223 G224 P225 F94 A95 N96 S97 G98 P99 25861763 SQSALTQPASVSGSPGQSITISCTGTSSDIGAYNYVSWYQQYPGKAPKLLIYDVSNRPSGISNRFSGSKSGDTASLTISGLQAEDEADYYCSSFANSGPLFGGGTKVTVL 4rav C 2.50 BS01 III F 1 S31 S33 S35 W47 V50 I51 S52 Y53 N57 K58 Y59 D99 R100 F102 S30 S32 S34 W46 V49 I50 S51 Y52 N56 K57 Y58 D98 R99 F101 25861763 VQLQESGGGLVQPGGSLRLSCAASGFTFSSYSMSWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDRYFDLWGRGTLVTVSSGGG 4rd6 A 1.94 BS01 GDP A 1 D19 H20 G21 K22 T23 T24 N149 K150 D152 V153 S184 A185 L186 D18 H19 G20 K21 T22 T23 N139 K140 D142 V143 S174 A175 L176 25690901 AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 4rx0 A 2.25 BS01 D65 A 1 L172 L176 G181 E182 C184 H185 F188 L197 F227 L240 I263 R265 I272 L531 V532 M536 L12 L16 G21 E22 C24 H25 F28 L37 F67 L80 I103 R105 I112 L332 V333 M337 1.3.5.2 26180101 YNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPEAGKLKNIILSVKEEIDNLEKNNIMNDEFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH 4rx0 A 2.25 BS02 FMN A 1 A224 A225 G226 K229 T249 I263 I272 N274 C276 K429 S457 N458 T459 S477 G478 L481 S505 G506 G507 Y528 S529 A64 A65 G66 K69 T89 I103 I112 N114 C116 K230 S258 N259 T260 S278 G279 L282 S306 G307 G308 Y329 S330 1.3.5.2 26180101 YNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPEAGKLKNIILSVKEEIDNLEKNNIMNDEFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKH 4tpr H 1.60 BS01 33O H 1 N163 S164 S166 L167 V191 T195 T200 T202 K213 D215 N163 S164 S166 L167 V191 T195 T200 T202 K213 D215 EVQLQQSGAEIVRSGASVKLSCAASGFNIKDYYMHWVKQRPEQGLEWIGWIDPENGDIAYAPKFQGKATMTADTSSNTAYLQLSRLTSEDTAVYFCNGRGGMITTDFFDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR 4tqe L 1.60 BS01 III A 1 Y37 E39 Y41 K55 F94 G96 V99 W101 Y37 E39 Y41 K55 F94 G96 V99 W101 DVLMTQTPLSLPVSLGDQASISCRSSQSIVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE 4tqe H 1.60 BS01 III A 1 K30 D31 Y33 H35 W50 D52 E54 D57 A59 R99 G100 G101 M102 I103 F107 K30 D31 Y33 H35 W50 D52 E54 D57 A59 R99 G100 G101 M102 I103 F107 EVQLQQSGAEIVRSGASVKLSCAASGFNIKDYYMHWVKQRPEQGLEWIGWIDPENGDIAYAPKFQGKATMTADTSSNTAYLQLSRLTSEDTAVYFCNGRGGMITTDFFDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVP 4try A 2.75 BS01 III D 1 G72 Q73 G74 D93 Y132 T133 Q134 F169 I179 Y259 I287 D289 G291 T292 T293 N294 R296 G13 Q14 G15 D34 Y73 T74 Q75 F110 I120 Y200 I228 D230 G232 T233 T234 N235 R237 3.4.23.46 FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4try B 2.75 BS01 III E 1 G72 Q73 G74 D93 Y132 T133 Q134 F169 I171 W176 I179 Y259 I287 D289 G291 T292 T293 N294 R296 G13 Q14 G15 D34 Y73 T74 Q75 F110 I112 W117 I120 Y200 I228 D230 G232 T233 T234 N235 R237 3.4.23.46 FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI 4try C 2.75 BS01 III F 1 S71 G72 D93 Y132 T133 Q134 F169 I171 Y259 I287 D289 G291 T292 T293 N294 R296 S12 G13 D34 Y73 T74 Q75 F110 I112 Y200 I228 D230 G232 T233 T234 N235 R237 3.4.23.46 FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI 4ttu A 2.18 BS01 CA A 1 D2164 D2170 F2214 N2693 D376 D382 F426 N905 2.4.1.5 KGLRQDSNGKLRYFDLTTGIQAKGQFVTIGQETYYFSKDHGDAQLLPMVTEGHYGTITTAWVYRDQNNTILKGLQNINGTLQFFDPYTGEQLKGGVAKYDDKLFYFESGKGNLVSTVAGDYQDGHYISQDGQTRYADKQNQLVKGLVTVNGALQYFDNATGNQIKNQQVIVDGKTYYFDDKGNGEYLFTNTLDMSTNAFSTKNVAFNHDSSSFDHTVDGFLTADTWYRPKSILANGTTWRDSTDKDMRPLITVWWPNKNVQVNYLNFMKANGLLTTAAQYTLHSDQYDLNQAAQDVQVAIERRIASEHGTDWLQKLLFESQNNNPSFVKQQFIWNKDSEYHGGGDAWFQGGYLKYGNNPLTPTTNSDYRQPGNAFDFLLANDVDNSNPVVQAENLNWLHYLMNFGTITAGQDDANFDSIRIDAVDFIHNDTIQRTYDYLRDAYQVQQSEAKANQHISLVEAGLDAGTSTIHNDALIESNLREAATLSLTNEPGKNKPLTNMLQDVDGGTLITDHTQNSTENQATPNYSIIHAHDKGVQEKVGAAITDATGADWTNFTDEQLKAGLELFYKDQRATNKKYNSYNIPSIYALMLTNKDTVPRMYYGDMYQDDGQYMANKSIYYDALVSLMTARKSYVSGGQTMSVDNHGLLKSVRFGKDAMTANDLGTSATRTEGLGVIIGNDPKLQLNDSDKVTLDMGAAHKNQKYRAVILTTRDGLATFNSDQAPTAWTNDQGTLTFSNQEINGQDNTQIRGVANPQVSGYLAVWVPVGASDNQDARTAATTTENHDGKVLHSNAALDSNLIYEGFSNFQPKATTHDELTNVVIAKNADVFNNWGITSFEMAPQYRSSGDHTFLDSTIDNGYAFTDRYDLGFNTPTKYGTDGDLRATIQALHHANMQVMADVVDNQVYNLPGKEVVSATRAGVYGNDDATGFGTQLYVTNSVGGGQYQEKYAGQYLEALKAKYPDLFEGKAYDYWYKNYANDGSNPYYTLSHGDRESIPADVAIKQWSAKYMNGTNVLGNGMGYVLKDWHNGQYFKLD 4ttu A 2.18 BS02 GLC A 1 Y1834 Q1870 Q1879 K1881 K1898 Y54 Q82 Q91 K93 K110 2.4.1.5 KGLRQDSNGKLRYFDLTTGIQAKGQFVTIGQETYYFSKDHGDAQLLPMVTEGHYGTITTAWVYRDQNNTILKGLQNINGTLQFFDPYTGEQLKGGVAKYDDKLFYFESGKGNLVSTVAGDYQDGHYISQDGQTRYADKQNQLVKGLVTVNGALQYFDNATGNQIKNQQVIVDGKTYYFDDKGNGEYLFTNTLDMSTNAFSTKNVAFNHDSSSFDHTVDGFLTADTWYRPKSILANGTTWRDSTDKDMRPLITVWWPNKNVQVNYLNFMKANGLLTTAAQYTLHSDQYDLNQAAQDVQVAIERRIASEHGTDWLQKLLFESQNNNPSFVKQQFIWNKDSEYHGGGDAWFQGGYLKYGNNPLTPTTNSDYRQPGNAFDFLLANDVDNSNPVVQAENLNWLHYLMNFGTITAGQDDANFDSIRIDAVDFIHNDTIQRTYDYLRDAYQVQQSEAKANQHISLVEAGLDAGTSTIHNDALIESNLREAATLSLTNEPGKNKPLTNMLQDVDGGTLITDHTQNSTENQATPNYSIIHAHDKGVQEKVGAAITDATGADWTNFTDEQLKAGLELFYKDQRATNKKYNSYNIPSIYALMLTNKDTVPRMYYGDMYQDDGQYMANKSIYYDALVSLMTARKSYVSGGQTMSVDNHGLLKSVRFGKDAMTANDLGTSATRTEGLGVIIGNDPKLQLNDSDKVTLDMGAAHKNQKYRAVILTTRDGLATFNSDQAPTAWTNDQGTLTFSNQEINGQDNTQIRGVANPQVSGYLAVWVPVGASDNQDARTAATTTENHDGKVLHSNAALDSNLIYEGFSNFQPKATTHDELTNVVIAKNADVFNNWGITSFEMAPQYRSSGDHTFLDSTIDNGYAFTDRYDLGFNTPTKYGTDGDLRATIQALHHANMQVMADVVDNQVYNLPGKEVVSATRAGVYGNDDATGFGTQLYVTNSVGGGQYQEKYAGQYLEALKAKYPDLFEGKAYDYWYKNYANDGSNPYYTLSHGDRESIPADVAIKQWSAKYMNGTNVLGNGMGYVLKDWHNGQYFKLD 4ttu A 2.18 BS03 GLC A 2 W1849 K1881 G1897 W61 K93 G109 2.4.1.5 KGLRQDSNGKLRYFDLTTGIQAKGQFVTIGQETYYFSKDHGDAQLLPMVTEGHYGTITTAWVYRDQNNTILKGLQNINGTLQFFDPYTGEQLKGGVAKYDDKLFYFESGKGNLVSTVAGDYQDGHYISQDGQTRYADKQNQLVKGLVTVNGALQYFDNATGNQIKNQQVIVDGKTYYFDDKGNGEYLFTNTLDMSTNAFSTKNVAFNHDSSSFDHTVDGFLTADTWYRPKSILANGTTWRDSTDKDMRPLITVWWPNKNVQVNYLNFMKANGLLTTAAQYTLHSDQYDLNQAAQDVQVAIERRIASEHGTDWLQKLLFESQNNNPSFVKQQFIWNKDSEYHGGGDAWFQGGYLKYGNNPLTPTTNSDYRQPGNAFDFLLANDVDNSNPVVQAENLNWLHYLMNFGTITAGQDDANFDSIRIDAVDFIHNDTIQRTYDYLRDAYQVQQSEAKANQHISLVEAGLDAGTSTIHNDALIESNLREAATLSLTNEPGKNKPLTNMLQDVDGGTLITDHTQNSTENQATPNYSIIHAHDKGVQEKVGAAITDATGADWTNFTDEQLKAGLELFYKDQRATNKKYNSYNIPSIYALMLTNKDTVPRMYYGDMYQDDGQYMANKSIYYDALVSLMTARKSYVSGGQTMSVDNHGLLKSVRFGKDAMTANDLGTSATRTEGLGVIIGNDPKLQLNDSDKVTLDMGAAHKNQKYRAVILTTRDGLATFNSDQAPTAWTNDQGTLTFSNQEINGQDNTQIRGVANPQVSGYLAVWVPVGASDNQDARTAATTTENHDGKVLHSNAALDSNLIYEGFSNFQPKATTHDELTNVVIAKNADVFNNWGITSFEMAPQYRSSGDHTFLDSTIDNGYAFTDRYDLGFNTPTKYGTDGDLRATIQALHHANMQVMADVVDNQVYNLPGKEVVSATRAGVYGNDDATGFGTQLYVTNSVGGGQYQEKYAGQYLEALKAKYPDLFEGKAYDYWYKNYANDGSNPYYTLSHGDRESIPADVAIKQWSAKYMNGTNVLGNGMGYVLKDWHNGQYFKLD 4ttu A 2.18 BS04 GLC A 3 Y1914 T1921 Q1942 Q1951 K1953 K1969 Y126 T133 Q154 Q163 K165 K181 2.4.1.5 KGLRQDSNGKLRYFDLTTGIQAKGQFVTIGQETYYFSKDHGDAQLLPMVTEGHYGTITTAWVYRDQNNTILKGLQNINGTLQFFDPYTGEQLKGGVAKYDDKLFYFESGKGNLVSTVAGDYQDGHYISQDGQTRYADKQNQLVKGLVTVNGALQYFDNATGNQIKNQQVIVDGKTYYFDDKGNGEYLFTNTLDMSTNAFSTKNVAFNHDSSSFDHTVDGFLTADTWYRPKSILANGTTWRDSTDKDMRPLITVWWPNKNVQVNYLNFMKANGLLTTAAQYTLHSDQYDLNQAAQDVQVAIERRIASEHGTDWLQKLLFESQNNNPSFVKQQFIWNKDSEYHGGGDAWFQGGYLKYGNNPLTPTTNSDYRQPGNAFDFLLANDVDNSNPVVQAENLNWLHYLMNFGTITAGQDDANFDSIRIDAVDFIHNDTIQRTYDYLRDAYQVQQSEAKANQHISLVEAGLDAGTSTIHNDALIESNLREAATLSLTNEPGKNKPLTNMLQDVDGGTLITDHTQNSTENQATPNYSIIHAHDKGVQEKVGAAITDATGADWTNFTDEQLKAGLELFYKDQRATNKKYNSYNIPSIYALMLTNKDTVPRMYYGDMYQDDGQYMANKSIYYDALVSLMTARKSYVSGGQTMSVDNHGLLKSVRFGKDAMTANDLGTSATRTEGLGVIIGNDPKLQLNDSDKVTLDMGAAHKNQKYRAVILTTRDGLATFNSDQAPTAWTNDQGTLTFSNQEINGQDNTQIRGVANPQVSGYLAVWVPVGASDNQDARTAATTTENHDGKVLHSNAALDSNLIYEGFSNFQPKATTHDELTNVVIAKNADVFNNWGITSFEMAPQYRSSGDHTFLDSTIDNGYAFTDRYDLGFNTPTKYGTDGDLRATIQALHHANMQVMADVVDNQVYNLPGKEVVSATRAGVYGNDDATGFGTQLYVTNSVGGGQYQEKYAGQYLEALKAKYPDLFEGKAYDYWYKNYANDGSNPYYTLSHGDRESIPADVAIKQWSAKYMNGTNVLGNGMGYVLKDWHNGQYFKLD 4tvc A 1.85 BS01 CA A 1 D2164 D2170 F2214 N2693 D375 D381 F425 N904 2.4.1.5 KGLRQDSNGKLRYFDLTTGIQAKGQFVTIGQETYYFSKDHGDAQLLPMVTEGHYGTITAWVYRDQNNTILKGLQNINGTLQFFDPYTGEQLKGGVAKYDDKLFYFESGKGNLVSTVAGDYQDGHYISQDGQTRYADKQNQLVKGLVTVNGALQYFDNATGNQIKNQQVIVDGKTYYFDDKGNGEYLFTNTLDMSTNAFSTKNVAFNHDSSSFDHTVDGFLTADTWYRPKSILANGTTWRDSTDKDMRPLITVWWPNKNVQVNYLNFMKANGLLTTAAQYTLHSDQYDLNQAAQDVQVAIERRIASEHGTDWLQKLLFESQNNNPSFVKQQFIWNKDSEYHGGGDAWFQGGYLKYGNNPLTPTTNSDYRQPGNAFDFLLANDVDNSNPVVQAENLNWLHYLMNFGTITAGQDDANFDSIRIDAVDFIHNDTIQRTYDYLRDAYQVQQSEAKANQHISLVEAGLDAGTSTIHNDALIESNLREAATLSLTNEPGKNKPLTNMLQDVDGGTLITDHTQNSTENQATPNYSIIHAHDKGVQEKVGAAITDATGADWTNFTDEQLKAGLELFYKDQRATNKKYNSYNIPSIYALMLTNKDTVPRMYYGDMYQDDGQYMANKSIYYDALVSLMTARKSYVSGGQTMSVDNHGLLKSVRFGKDAMTANDLGTSATRTEGLGVIIGNDPKLQLNDSDKVTLDMGAAHKNQKYRAVILTTRDGLATFNSDQAPTAWTNDQGTLTFSNQEINGQDNTQIRGVANPQVSGYLAVWVPVGASDNQDARTAATTTENHDGKVLHSNAALDSNLIYEGFSNFQPKATTHDELTNVVIAKNADVFNNWGITSFEMAPQYRSSGDHTFLDSTIDNGYAFTDRYDLGFNTPTKYGTDGDLRATIQALHHANMQVMADVVDNQVYNLPGKEVVSATRAGVYGNDDATGFGTQLYVTNSVGGGQYQEKYAGQYLEALKAKYPDLFEGKAYDYWYKNYANDGSNPYYTLSHGDRESIPADVAIKQWSAKYMNGTNVLGNGMGYVLKDWHNGQYFKL 4tvc A 1.85 BS02 GLC A 1 Y1834 Q1870 Q1879 K1881 K1898 Y54 Q81 Q90 K92 K109 2.4.1.5 KGLRQDSNGKLRYFDLTTGIQAKGQFVTIGQETYYFSKDHGDAQLLPMVTEGHYGTITAWVYRDQNNTILKGLQNINGTLQFFDPYTGEQLKGGVAKYDDKLFYFESGKGNLVSTVAGDYQDGHYISQDGQTRYADKQNQLVKGLVTVNGALQYFDNATGNQIKNQQVIVDGKTYYFDDKGNGEYLFTNTLDMSTNAFSTKNVAFNHDSSSFDHTVDGFLTADTWYRPKSILANGTTWRDSTDKDMRPLITVWWPNKNVQVNYLNFMKANGLLTTAAQYTLHSDQYDLNQAAQDVQVAIERRIASEHGTDWLQKLLFESQNNNPSFVKQQFIWNKDSEYHGGGDAWFQGGYLKYGNNPLTPTTNSDYRQPGNAFDFLLANDVDNSNPVVQAENLNWLHYLMNFGTITAGQDDANFDSIRIDAVDFIHNDTIQRTYDYLRDAYQVQQSEAKANQHISLVEAGLDAGTSTIHNDALIESNLREAATLSLTNEPGKNKPLTNMLQDVDGGTLITDHTQNSTENQATPNYSIIHAHDKGVQEKVGAAITDATGADWTNFTDEQLKAGLELFYKDQRATNKKYNSYNIPSIYALMLTNKDTVPRMYYGDMYQDDGQYMANKSIYYDALVSLMTARKSYVSGGQTMSVDNHGLLKSVRFGKDAMTANDLGTSATRTEGLGVIIGNDPKLQLNDSDKVTLDMGAAHKNQKYRAVILTTRDGLATFNSDQAPTAWTNDQGTLTFSNQEINGQDNTQIRGVANPQVSGYLAVWVPVGASDNQDARTAATTTENHDGKVLHSNAALDSNLIYEGFSNFQPKATTHDELTNVVIAKNADVFNNWGITSFEMAPQYRSSGDHTFLDSTIDNGYAFTDRYDLGFNTPTKYGTDGDLRATIQALHHANMQVMADVVDNQVYNLPGKEVVSATRAGVYGNDDATGFGTQLYVTNSVGGGQYQEKYAGQYLEALKAKYPDLFEGKAYDYWYKNYANDGSNPYYTLSHGDRESIPADVAIKQWSAKYMNGTNVLGNGMGYVLKDWHNGQYFKL 4tvc A 1.85 BS03 GLC A 2 K1881 G1897 K1898 K92 G108 K109 2.4.1.5 KGLRQDSNGKLRYFDLTTGIQAKGQFVTIGQETYYFSKDHGDAQLLPMVTEGHYGTITAWVYRDQNNTILKGLQNINGTLQFFDPYTGEQLKGGVAKYDDKLFYFESGKGNLVSTVAGDYQDGHYISQDGQTRYADKQNQLVKGLVTVNGALQYFDNATGNQIKNQQVIVDGKTYYFDDKGNGEYLFTNTLDMSTNAFSTKNVAFNHDSSSFDHTVDGFLTADTWYRPKSILANGTTWRDSTDKDMRPLITVWWPNKNVQVNYLNFMKANGLLTTAAQYTLHSDQYDLNQAAQDVQVAIERRIASEHGTDWLQKLLFESQNNNPSFVKQQFIWNKDSEYHGGGDAWFQGGYLKYGNNPLTPTTNSDYRQPGNAFDFLLANDVDNSNPVVQAENLNWLHYLMNFGTITAGQDDANFDSIRIDAVDFIHNDTIQRTYDYLRDAYQVQQSEAKANQHISLVEAGLDAGTSTIHNDALIESNLREAATLSLTNEPGKNKPLTNMLQDVDGGTLITDHTQNSTENQATPNYSIIHAHDKGVQEKVGAAITDATGADWTNFTDEQLKAGLELFYKDQRATNKKYNSYNIPSIYALMLTNKDTVPRMYYGDMYQDDGQYMANKSIYYDALVSLMTARKSYVSGGQTMSVDNHGLLKSVRFGKDAMTANDLGTSATRTEGLGVIIGNDPKLQLNDSDKVTLDMGAAHKNQKYRAVILTTRDGLATFNSDQAPTAWTNDQGTLTFSNQEINGQDNTQIRGVANPQVSGYLAVWVPVGASDNQDARTAATTTENHDGKVLHSNAALDSNLIYEGFSNFQPKATTHDELTNVVIAKNADVFNNWGITSFEMAPQYRSSGDHTFLDSTIDNGYAFTDRYDLGFNTPTKYGTDGDLRATIQALHHANMQVMADVVDNQVYNLPGKEVVSATRAGVYGNDDATGFGTQLYVTNSVGGGQYQEKYAGQYLEALKAKYPDLFEGKAYDYWYKNYANDGSNPYYTLSHGDRESIPADVAIKQWSAKYMNGTNVLGNGMGYVLKDWHNGQYFKL 4tvc A 1.85 BS04 GLC A 3 Y1914 Q1942 Q1951 K1953 K1969 Y125 Q153 Q162 K164 K180 2.4.1.5 KGLRQDSNGKLRYFDLTTGIQAKGQFVTIGQETYYFSKDHGDAQLLPMVTEGHYGTITAWVYRDQNNTILKGLQNINGTLQFFDPYTGEQLKGGVAKYDDKLFYFESGKGNLVSTVAGDYQDGHYISQDGQTRYADKQNQLVKGLVTVNGALQYFDNATGNQIKNQQVIVDGKTYYFDDKGNGEYLFTNTLDMSTNAFSTKNVAFNHDSSSFDHTVDGFLTADTWYRPKSILANGTTWRDSTDKDMRPLITVWWPNKNVQVNYLNFMKANGLLTTAAQYTLHSDQYDLNQAAQDVQVAIERRIASEHGTDWLQKLLFESQNNNPSFVKQQFIWNKDSEYHGGGDAWFQGGYLKYGNNPLTPTTNSDYRQPGNAFDFLLANDVDNSNPVVQAENLNWLHYLMNFGTITAGQDDANFDSIRIDAVDFIHNDTIQRTYDYLRDAYQVQQSEAKANQHISLVEAGLDAGTSTIHNDALIESNLREAATLSLTNEPGKNKPLTNMLQDVDGGTLITDHTQNSTENQATPNYSIIHAHDKGVQEKVGAAITDATGADWTNFTDEQLKAGLELFYKDQRATNKKYNSYNIPSIYALMLTNKDTVPRMYYGDMYQDDGQYMANKSIYYDALVSLMTARKSYVSGGQTMSVDNHGLLKSVRFGKDAMTANDLGTSATRTEGLGVIIGNDPKLQLNDSDKVTLDMGAAHKNQKYRAVILTTRDGLATFNSDQAPTAWTNDQGTLTFSNQEINGQDNTQIRGVANPQVSGYLAVWVPVGASDNQDARTAATTTENHDGKVLHSNAALDSNLIYEGFSNFQPKATTHDELTNVVIAKNADVFNNWGITSFEMAPQYRSSGDHTFLDSTIDNGYAFTDRYDLGFNTPTKYGTDGDLRATIQALHHANMQVMADVVDNQVYNLPGKEVVSATRAGVYGNDDATGFGTQLYVTNSVGGGQYQEKYAGQYLEALKAKYPDLFEGKAYDYWYKNYANDGSNPYYTLSHGDRESIPADVAIKQWSAKYMNGTNVLGNGMGYVLKDWHNGQYFKL 4tz9 A 2.13 BS01 ZN A 1 H120 H122 H189 H81 H83 H150 GPGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTNDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4tz9 A 2.13 BS02 CO A 1 N95 G127 D130 N56 G88 D91 GPGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTNDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4tze A 1.57 BS01 ZN A 1 H120 H122 H189 H80 H82 H149 PGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLLVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4tze A 1.57 BS02 ZN A 2 D124 C208 H250 D84 C168 H210 PGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLLVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4tze B 1.57 BS01 ZN B 1 H120 H122 H189 H79 H81 H148 GDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLLVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4tze B 1.57 BS02 ZN B 2 D124 C208 H250 D83 C167 H209 GDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLLVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4tzf A 1.22 BS01 ZN A 1 H120 H122 H189 H79 H81 H148 GDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMGALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4tzf A 1.22 BS02 ZN A 2 D124 C208 H250 D83 C167 H209 GDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMGALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4u01 A 2.80 BS01 III K 1 T4 A5 Y6 S7 Q8 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 L44 A59 K62 T63 L64 A65 V107 T108 T4 A5 Y6 S7 Q8 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 L44 A59 K62 T63 L64 A65 V107 T108 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 A 2.80 BS02 39W A 1 Q41 F43 H57 G58 D79 Q80 D81 V132 K136 G137 S138 S139 F154 R155 A156 A157 C159 Q41 F43 H57 G58 D79 Q80 D81 V132 K136 G137 S138 S139 F154 R155 A156 A157 C159 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 A 2.80 BS03 ZN A 1 C97 C99 C145 S147 C97 C99 C145 S147 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 B 2.80 BS01 III L 1 I3 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 A65 T108 I3 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 A65 T108 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 B 2.80 BS02 39W B 1 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 C159 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 C159 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 B 2.80 BS03 ZN B 1 C97 T98 C99 C145 C97 T98 C99 C145 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 C 2.80 BS01 III M 1 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 L64 A65 T108 L144 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 L64 A65 T108 L144 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 C 2.80 BS02 39W C 1 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 C 2.80 BS03 ZN C 1 C97 C99 C145 C97 C99 C145 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 D 2.80 BS01 III N 1 I3 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 E30 V33 Q34 V35 V36 S37 K62 T63 L64 A65 T108 R109 I3 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 E30 V33 Q34 V35 V36 S37 K62 T63 L64 A65 T108 R109 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 D 2.80 BS02 39W D 1 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 K136 G137 S139 F154 R155 A156 A157 C159 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 K136 G137 S139 F154 R155 A156 A157 C159 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 D 2.80 BS03 ZN D 1 C97 C99 C145 C97 C99 C145 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 E 2.80 BS01 III O 1 T4 A5 Y6 S7 Q8 T10 R11 C16 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 L64 A65 P70 T108 R109 T4 A5 Y6 S7 Q8 T10 R11 C16 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 L64 A65 P70 T108 R109 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 E 2.80 BS02 39W E 1 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 E 2.80 BS03 ZN E 1 C97 C99 C145 C97 C99 C145 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 F 2.80 BS01 III P 1 T4 A5 Y6 S7 Q8 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 L64 A65 W85 T108 R109 T4 A5 Y6 S7 Q8 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 L64 A65 W85 T108 R109 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 F 2.80 BS02 39W F 1 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 C159 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 C159 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 F 2.80 BS03 ZN F 1 C97 C99 C145 C97 C99 C145 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 G 2.80 BS01 III Q 1 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 T38 K62 T63 L64 A65 V107 T108 R109 L144 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 Q28 E30 E32 V33 Q34 V35 V36 S37 T38 K62 T63 L64 A65 V107 T108 R109 L144 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 G 2.80 BS02 39W G 1 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 G 2.80 BS03 ZN G 1 C97 C99 C145 C97 C99 C145 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 H 2.80 BS01 III T 1 I3 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 D25 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 L64 A65 T108 R109 I3 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 D25 Q28 E30 E32 V33 Q34 V35 V36 S37 K62 T63 L64 A65 T108 R109 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 H 2.80 BS02 39W H 1 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 C159 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 C159 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 H 2.80 BS03 ZN H 1 C97 C99 C145 C97 C99 C145 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 J 2.80 BS01 III U 1 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 G23 Q28 E30 E32 V33 Q34 V35 V36 S37 L44 K62 T63 L64 A65 P70 T108 R109 T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 T19 S20 G23 Q28 E30 E32 V33 Q34 V35 V36 S37 L44 K62 T63 L64 A65 P70 T108 R109 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 J 2.80 BS02 39W J 1 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 C159 Q41 F43 Y56 H57 G58 D79 Q80 D81 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 C159 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u01 J 2.80 BS03 ZN J 1 C97 C99 S101 C145 C97 C99 S101 C145 APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRAS 4u1p A 1.40 BS01 III B 1 R30 R50 S52 E53 T54 S60 K75 H76 Y77 K78 I89 T90 Y105 G111 R14 R34 S36 E37 T38 S44 K59 H60 Y61 K62 I73 T74 Y89 G95 2.7.10.2 HHSSMEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCH 4u2k B 2.13 BS01 4WR B 1 T94 G95 F161 Q165 R167 E195 M196 I220 T93 G94 F160 Q164 R166 E194 M195 I219 2.4.2.3 TKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQTLKETEARSIKVVVEAARKMLK 4u2k D 2.13 BS01 M5F D 1 T94 G95 F161 Q165 R167 F194 E195 M196 I219 I220 T92 G93 F159 Q163 R165 F192 E193 M194 I217 I218 2.4.2.3 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKETEARSIKVVVEAARKMLK 4u2k D 2.13 BS02 4WR D 1 T94 G95 F161 Q165 R167 F194 E195 M196 I219 T92 G93 F159 Q163 R165 F192 E193 M194 I217 2.4.2.3 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKETEARSIKVVVEAARKMLK 4u2k F 2.13 BS01 M5F F 1 T93 F161 Q165 R167 E195 M196 I220 T91 F159 Q163 R165 E193 M194 I218 2.4.2.3 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 4u3f C 3.23 BS01 HEM C 1 L42 Q45 I46 G49 L50 L52 A53 Y56 R81 H84 A88 F91 L124 T127 G131 Y132 L134 P135 H183 F184 P187 L42 Q45 I46 G49 L50 L52 A53 Y56 R81 H84 A88 F91 L124 T127 G131 Y132 L134 P135 H183 F184 P187 MAPNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPTIGTLENKMLNY 4u3f C 3.23 BS02 HEM C 2 W32 G35 L38 F91 I95 H98 I99 R101 S107 T113 W114 G117 L120 L121 I190 T194 H197 L198 L201 S206 N207 W32 G35 L38 F91 I95 H98 I99 R101 S107 T113 W114 G117 L120 L121 I190 T194 H197 L198 L201 S206 N207 MAPNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPTIGTLENKMLNY 4u3f C 3.23 BS03 Y52 C 1 M125 A126 F129 Y132 V133 M139 G143 A144 I147 K270 P271 E272 Y274 F275 Y279 L295 M125 A126 F129 Y132 V133 M139 G143 A144 I147 K270 P271 E272 Y274 F275 Y279 L295 MAPNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPTIGTLENKMLNY 4u3f C 3.23 BS04 U10 C 1 S18 L19 L22 A24 I28 S36 A39 L198 H202 S206 F221 Y225 D229 S18 L19 L22 A24 I28 S36 A39 L198 H202 S206 F221 Y225 D229 MAPNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPTIGTLENKMLNY 4u3f D 3.23 BS01 HEC D 1 V36 C37 C40 H41 N105 A108 P110 P111 I116 R120 Y126 L130 F153 G159 M160 P163 I164 V36 C37 C40 H41 N105 A108 P110 P111 I116 R120 Y126 L130 F153 G159 M160 P163 I164 1.10.2.2 GELELHPPAFPWSHGGPLSALDHSSVRRGFQVYKQVCSACHSMDYVAFRNLIGVTHTEAEAKALAEEVEVQDGPDENGELFMRPGKISDYFPKPYPNPEAARAANNGALPPDLSYIVNARHGGEDYVFSLLTGYCDPPAGVVVREGLHYNPYFPGQAIGMAPPIYNEILEYDDGTPATMSQIAKDVCTFLRWAAEPEHDQRKRMGLKMLLISALLTSLLYYMKRHKWSVLKSRKMAYRPPK 4u3f E 3.23 BS01 FES E 1 C139 H141 L142 C158 C160 H161 S163 C139 H141 L142 C158 C160 H161 S163 1.10.2.2 VHNDVTVPDFSAYRREDVMDATTSSQTSSEDRKGFSYLVTATACVATAYAAKNVVTQFISSLSASADVLALSKIEIKLSDIPEGKNVAFKWRGKPLFVRHRTQAEINQEAEVDVSKLRDPQHDLDRVKKPEWVILVGVCTHLGCVPIANSGDFGGYYCPCHGSHYDASGRIRKGPAPYNLEVPTYQFVGDDLVVVG 4u3f P 3.23 BS01 HEM P 1 L42 Q45 I46 G49 L50 L52 A53 Y56 R81 H84 A88 F91 L124 T127 G131 Y132 L134 P135 H183 F184 P187 L41 Q44 I45 G48 L49 L51 A52 Y55 R80 H83 A87 F90 L123 T126 G130 Y131 L133 P134 H182 F183 P186 APNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPTIGTLENKMLNY 4u3f P 3.23 BS02 HEM P 2 W32 G35 L38 F91 I95 H98 I99 R101 S107 T113 W114 G117 L120 L121 I190 T194 H197 L198 L201 S206 N207 W31 G34 L37 F90 I94 H97 I98 R100 S106 T112 W113 G116 L119 L120 I189 T193 H196 L197 L200 S205 N206 APNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPTIGTLENKMLNY 4u3f P 3.23 BS03 Y52 P 1 L122 M125 A126 A128 F129 Y132 V133 G143 A144 I147 K270 P271 E272 Y274 F275 Y279 L295 L121 M124 A125 A127 F128 Y131 V132 G142 A143 I146 K269 P270 E271 Y273 F274 Y278 L294 APNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPTIGTLENKMLNY 4u3f P 3.23 BS04 U10 P 1 S18 L19 L22 A24 I28 S36 A39 L198 L201 H202 S206 F221 D229 S17 L18 L21 A23 I27 S35 A38 L197 L200 H201 S205 F220 D228 APNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPTIGTLENKMLNY 4u3f Q 3.23 BS01 HEC Q 1 V36 C37 C40 H41 N105 A108 P110 P111 I116 R120 Y126 L130 F153 G159 M160 P163 I164 V36 C37 C40 H41 N105 A108 P110 P111 I116 R120 Y126 L130 F153 G159 M160 P163 I164 1.10.2.2 GELELHPPAFPWSHGGPLSALDHSSVRRGFQVYKQVCSACHSMDYVAFRNLIGVTHTEAEAKALAEEVEVQDGPDENGELFMRPGKISDYFPKPYPNPEAARAANNGALPPDLSYIVNARHGGEDYVFSLLTGYCDPPAGVVVREGLHYNPYFPGQAIGMAPPIYNEILEYDDGTPATMSQIAKDVCTFLRWAAEPEHDQRKRMGLKMLLISALLTSLLYYMKRHKWSVLKSRKMAYRPPK 4u3f R 3.23 BS01 FES R 1 C139 H141 L142 C144 C158 C160 H161 S163 C139 H141 L142 C144 C158 C160 H161 S163 1.10.2.2 VHNDVTVPDFSAYRREDVMDATTSSQTSSEDRKGFSYLVTATACVATAYAAKNVVTQFISSLSASADVLALSKIEIKLSDIPEGKNVAFKWRGKPLFVRHRTQAEINQEAEVDVSKLRDPQHDLDRVKKPEWVILVGVCTHLGCVPIANSGDFGGYYCPCHGSHYDASGRIRKGPAPYNLEVPTYQFVGDDLVVVG 4u3s B 1.64 BS01 CA B 1 D121 M122 D129 A131 D136 D93 M94 D101 A103 D108 GTTVSGYINPDFVTTSTTAPIVKAGFTVEIVGTTKSAVTDSNGYFEIKDVAAGTYTVKITKANYLTREIANVSVTADKELSTSASPILMWAGDMAIGGTQDGAINLEDILEICKAFGTSSTDAKYQVGLDLNRDGAISLEDVMIVAKHFNKVSSDY 4u3s B 1.64 BS02 CA B 2 D158 N160 D162 A164 D169 D130 N132 D134 A136 D141 GTTVSGYINPDFVTTSTTAPIVKAGFTVEIVGTTKSAVTDSNGYFEIKDVAAGTYTVKITKANYLTREIANVSVTADKELSTSASPILMWAGDMAIGGTQDGAINLEDILEICKAFGTSSTDAKYQVGLDLNRDGAISLEDVMIVAKHFNKVSSDY 4u4k A 1.20 BS01 3E0 A 1 L704 N705 L707 G708 Q711 M742 M745 M749 R752 F764 M780 M787 F876 A877 L35 N36 L38 G39 Q42 M73 M76 M80 R83 F95 M111 M118 F207 A208 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFAFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 4u4m A 3.09 BS01 URE A 1 F147 T176 F265 F136 T165 F254 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m A 3.09 BS02 URE A 2 D178 Y203 D205 P256 D167 Y192 D194 P245 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m A 3.09 BS03 PYR A 1 P20 F52 G55 S56 G57 Y145 K174 I219 P9 F41 G44 S45 G46 Y134 K163 I208 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m B 3.09 BS01 URE B 1 Y203 A221 F265 Y192 A210 F254 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m B 3.09 BS02 URE B 2 D262 S289 P290 D251 S278 P279 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m B 3.09 BS03 PYR B 1 P20 F52 G55 S56 G57 Y145 K174 P9 F41 G44 S45 G46 Y134 K163 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m C 3.09 BS01 URE A 3 A181 R184 A170 R173 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m C 3.09 BS02 PYR C 1 P20 F52 G55 S56 G57 Y145 K174 I219 P9 F41 G44 S45 G46 Y134 K163 I208 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m D 3.09 BS01 URE D 1 F147 T176 G202 F265 F136 T165 G191 F254 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m D 3.09 BS02 URE D 2 D262 S289 P290 D251 S278 P279 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4u4m D 3.09 BS03 PYR D 1 P20 F52 G55 S56 G57 Y145 K174 G202 I219 P9 F41 G44 S45 G46 Y134 K163 G191 I208 ALFTGIIPPVSTIFTADGQLDKPGTAALIDDLIKAGVDGLFFLGSGGEFSQLGAEERKAIARFAIDHVDRRVPVLIGTGGTNARETIELSQHAQQAGADGIVVINPYYWKVSEANLIRYFEQVADSVTLPVMLYNFPALTGQDLTPALVKTLADSRSNIIGIKDTIDSVAHLRSMIHTVKGAHPHFTVLCGYDDHLFNTLLLGGDGAISASGNFAPQVSVNLLKAWRDGDVAKAAGYHQTLLQIPQMYQLDTPFVNVIKEAIVLCGRPVSTHVLPPASPLDEPRKAQLKTLLQQLKLC 4usl A 1.65 BS01 III D 1 M81 L82 E97 V101 W105 H108 M132 R167 M56 L57 E72 V76 W80 H83 M107 R142 AFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 4usl A 1.65 BS02 CA A 1 D113 D115 S117 T119 E124 D88 D90 S92 T94 E99 AFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 4usl A 1.65 BS03 CA A 2 A43 D46 Q48 E53 A18 D21 Q23 E28 AFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 4usl A 1.65 BS04 CA A 3 D83 D85 S87 T89 E94 D58 D60 S62 T64 E69 AFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 4uvl A 2.00 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvl A 2.00 BS02 32X A 1 H1031 G1032 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H80 G81 Y99 Y109 F110 A111 K116 S117 Y120 E184 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvl C 2.00 BS01 ZN C 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvl C 2.00 BS02 32X C 1 H1031 G1032 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H80 G81 Y99 Y109 F110 A111 K116 S117 Y120 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvn A 2.20 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvn A 2.20 BS02 CDJ A 1 H1031 G1032 S1033 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvn B 2.20 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvn B 2.20 BS02 CDJ B 1 H1031 G1032 S1033 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 H80 G81 S82 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvo A 1.85 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvo A 1.85 BS02 5WW A 1 H1031 G1032 S1033 P1034 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 P83 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvo B 1.85 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvo B 1.85 BS02 5WW B 1 H1031 G1032 S1033 A1049 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H80 G81 S82 A98 Y99 Y109 F110 A111 K116 S117 Y120 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvp A 1.75 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAM 4uvp A 1.75 BS02 NGJ A 1 H1031 G1032 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 H80 G81 Y99 Y109 F110 A111 K116 S117 Y120 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAM 4uvp C 1.75 BS01 ZN C 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAM 4uvp C 1.75 BS02 NGJ C 1 H1031 G1032 S1033 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 H80 G81 S82 Y99 Y109 F110 A111 K116 S117 Y120 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAM 4uvs A 2.00 BS01 ZN A 1 C1081 H1084 C1089 C1092 C131 H134 C139 C142 2.4.2.30 26189030 SGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG 4uvs A 2.00 BS02 R4E A 1 H1031 G1032 P1034 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H81 G82 P84 Y100 Y110 F111 A112 K117 S118 Y121 E186 2.4.2.30 26189030 SGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG 4uvs C 2.00 BS01 ZN C 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvs C 2.00 BS02 R4E C 1 H1031 G1032 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvt A 1.95 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvt A 1.95 BS02 G1O A 1 H1031 G1032 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H80 G81 Y99 Y109 F110 A111 K116 S117 Y120 E185 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvt C 1.95 BS01 ZN C 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvt C 1.95 BS02 G1O C 1 H1031 G1032 Y1050 Y1060 A1062 K1067 S1068 Y1071 E1138 H80 G81 Y99 Y109 A111 K116 S117 Y120 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvu A 1.95 BS01 U1T A 1 H1031 G1032 S1033 F1035 A1049 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H80 G81 S82 F84 A98 Y99 Y109 F110 A111 K116 S117 Y120 E185 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvu A 1.95 BS02 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvu B 1.95 BS01 U1T B 1 H1031 G1032 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvu B 1.95 BS02 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvv A 1.90 BS01 W8L A 1 H1031 G1032 S1033 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E185 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvv A 1.90 BS02 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvv B 1.90 BS01 W8L B 1 H1031 G1032 S1033 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvv B 1.90 BS02 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvw A 2.10 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvw A 2.10 BS02 NYJ A 1 H1031 G1032 S1033 P1034 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 P83 Y99 Y109 F110 A111 K116 S117 Y120 I124 E185 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvw B 2.10 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvw B 2.10 BS02 NYJ B 1 H1031 G1032 S1033 P1034 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 P83 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvx A 1.95 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvx A 1.95 BS02 H2W A 1 H1031 G1032 S1033 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E185 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvx B 1.95 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvx B 1.95 BS02 H2W B 1 H1031 G1032 S1033 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvy A 1.95 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvy A 1.95 BS02 SGW A 1 H1031 G1032 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H80 G81 F84 Y99 Y109 F110 A111 K116 S117 Y120 E185 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvy B 1.95 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvy B 1.95 BS02 SGW B 1 H1031 G1032 S1033 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvz A 1.60 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvz A 1.60 BS02 5NN A 1 H1031 G1032 S1033 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 Y99 Y109 F110 A111 K116 S117 Y120 I124 E184 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvz C 1.60 BS01 ZN C 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4uvz C 1.60 BS02 5NN C 1 H1031 G1032 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26189030 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4wgf A 2.34 BS01 ROP A 1 D19 S59 N65 V113 V114 C118 D18 S58 N64 V112 V113 C117 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf A 2.34 BS02 HX2 A 1 P192 A195 N196 P191 A194 N195 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf A 2.34 BS03 HX2 A 2 L25 K37 V40 L41 V69 E71 L24 K36 V39 L40 V68 E70 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf B 2.34 BS01 ROP B 1 S59 N65 I88 V113 V114 C118 S58 N64 I87 V112 V113 C117 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf B 2.34 BS02 HX2 B 1 P192 A193 A195 N196 P191 A192 A194 N195 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf B 2.34 BS03 HX2 H 1 L25 K37 V40 V69 L24 K36 V39 V68 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf C 2.34 BS01 ROP C 1 D19 S59 N65 I88 V113 V114 C118 D18 S58 N64 I87 V112 V113 C117 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf C 2.34 BS02 HX2 C 1 P192 N196 P191 N195 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf C 2.34 BS03 HX2 G 1 L25 K37 V40 L41 V69 E71 L24 K36 V39 L40 V68 E70 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf D 2.34 BS01 ROP D 1 D19 S59 V113 V114 C118 D18 S58 V112 V113 C117 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf D 2.34 BS02 HX2 D 1 P192 N196 P191 N195 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf D 2.34 BS03 HX2 F 1 L25 K37 V40 L41 V69 L24 K36 V39 L40 V68 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf E 2.34 BS01 HX2 A 1 L25 K37 V69 E71 L24 K36 V68 E70 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf E 2.34 BS02 HX2 A 3 P192 N196 P191 N195 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf E 2.34 BS03 ROP E 1 D19 S59 N65 V113 V114 C118 D18 S58 N64 V112 V113 C117 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf F 2.34 BS01 HX2 D 1 L25 K37 V40 L41 V69 L24 K36 V39 L40 V68 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf F 2.34 BS02 ROP F 1 S59 N65 V113 V114 C118 S58 N64 V112 V113 C117 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf F 2.34 BS03 HX2 F 1 P192 N196 P191 N195 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf G 2.34 BS01 HX2 C 1 L25 K37 V40 L41 V69 L24 K36 V39 L40 V68 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf G 2.34 BS02 ROP G 1 D19 S59 N65 I88 V113 V114 C118 D18 S58 N64 I87 V112 V113 C117 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf G 2.34 BS03 HX2 G 1 P192 N196 P191 N195 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf H 2.34 BS01 HX2 B 1 L25 K37 V69 L24 K36 V68 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf H 2.34 BS02 ROP H 1 S59 N65 I88 V113 V114 C118 S58 N64 I87 V112 V113 C117 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wgf H 2.34 BS03 HX2 H 1 P192 A195 N196 P191 A194 N195 26184183 SFTYKRLDKNDAAVLFVDHQAGLLSLVRDFSPDEFKNNVLALADIARFFNLPTILTTSFEDGPNGPLVPELKEMFPQAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTDVCVAFPTLSALEEGFDVFVVTDASGTFNPVVRDAAWARMTAAGAQLMNWFSVGCELHRDWRNDIEGFGAILGGHLPAYANLIQSFGT 4wxh A 1.90 BS01 SAH A 1 Y142 R152 F167 G186 G187 E209 M210 G235 D236 F237 S251 F252 N256 W257 Y134 R144 F159 G178 G179 E201 M202 G227 D228 F229 S243 F244 N248 W249 2.1.1.292 RPQQIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQAVARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLLACDQDVAFDAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDAVRILTRCAEALEPGGRILIHERDDLHENSFNEQFSTELDLRMLVFLGGALRTREKWDGLAASAGLVVEEVRQLPSPTIPYDLSLLVLAPA 4wxh A 1.90 BS02 3VL A 1 W105 F155 L159 C161 D162 F252 N256 E299 L300 R303 M304 F307 W97 F147 L151 C153 D154 F244 N248 E291 L292 R295 M296 F299 2.1.1.292 RPQQIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQAVARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLLACDQDVAFDAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDAVRILTRCAEALEPGGRILIHERDDLHENSFNEQFSTELDLRMLVFLGGALRTREKWDGLAASAGLVVEEVRQLPSPTIPYDLSLLVLAPA 4wxh B 1.90 BS01 SAH B 1 Y142 R152 L159 F167 G186 G187 E209 M210 G235 D236 F237 S251 F252 N256 W257 Y131 R141 L148 F156 G175 G176 E198 M199 G224 D225 F226 S240 F241 N245 W246 2.1.1.292 QQIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALLRLIRHLVAIGLLEEAPGEFVPTEVGELLADDHPAAQRAWHDLTQAVARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLLACDQDVAFDAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDAVRILTRCAEALEPGGRILIHERDDLENSFNEQFSTELDLRMLVFLGGALRTREKWDGLAASAGLVVEEVRQLPSPTIPYDLSLLVLAPA 4wxh B 1.90 BS02 3VL B 1 W105 F155 L159 C161 A166 F252 N256 E299 L300 R303 M304 I340 W94 F144 L148 C150 A155 F241 N245 E287 L288 R291 M292 I328 2.1.1.292 QQIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALLRLIRHLVAIGLLEEAPGEFVPTEVGELLADDHPAAQRAWHDLTQAVARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLLACDQDVAFDAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDAVRILTRCAEALEPGGRILIHERDDLENSFNEQFSTELDLRMLVFLGGALRTREKWDGLAASAGLVVEEVRQLPSPTIPYDLSLLVLAPA 4x9r A 1.40 BS01 III B 1 K413 W414 V415 D416 Y417 L478 Y481 F482 Y485 L490 L491 R516 F535 H538 K540 K41 W42 V43 D44 Y45 L106 Y109 F110 Y113 L118 L119 R144 F163 H166 K168 2.7.11.21 26152807 HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLS 4x9v A 1.43 BS01 III B 1 K413 W414 V415 D416 Y417 L478 Y481 F482 Y485 L490 L491 R516 F535 H538 K540 R557 K42 W43 V44 D45 Y46 L107 Y110 F111 Y114 L119 L120 R138 F157 H160 K162 R179 2.7.11.21 26152807 CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRS 4x9w A 1.80 BS01 III B 1 K413 W414 V415 D416 Y417 L478 Y481 F482 Y485 L490 L491 R516 H538 K540 K42 W43 V44 D45 Y46 L107 Y110 F111 Y114 L119 L120 R145 H167 K169 2.7.11.21 26152807 CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSAS 4xee A 2.90 BS01 III B 1 D54 L55 D56 F128 H132 Y146 V224 T226 I238 R327 R328 F331 I334 W339 F344 Y347 Y351 D5 L6 D7 F72 H76 Y90 V168 T170 I182 R243 R244 F247 I250 W255 F260 Y263 Y267 3.2.1.17 GPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYASSAINPILYNLVSANFRQVFLSTLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLNNKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYGSGS 4xes A 2.60 BS01 III B 1 D54 L55 D56 F128 H132 Y146 V224 T226 R327 R328 F331 I334 D336 W339 F344 Y347 H348 Y351 D6 L7 D8 F80 H84 Y98 V176 T178 R251 R252 F255 I258 D260 W263 F268 Y271 H272 Y275 3.2.1.17 AGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYASSAINPILYNLVSANFRQVFLSTNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLNNKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYGSGS 4xmc A 1.42 BS01 HEM A 1 E27 Y30 F41 F43 E56 L58 H60 F69 N71 F88 T90 Y107 V109 I121 I123 L135 S137 E26 Y29 F40 F42 E55 L57 H59 F68 N70 F87 T89 Y106 V108 I120 I122 L134 S136 1.7.6.1 26167269 PGECSVNVIPKKNLDKAKFFSGTWYETHYLDMDPQATEKFCFSFAPRESGGTVKEALYHFNVDSKVSFYNTGTGPLESNGAKYTAKFNTVDKKGKEIKPADEKYSYTVTVIEAAKQSALIHICLQEDGKDIGDLYSVLNRNKNALPNKKIKKALNKVSLVLTKFVVTKDLDCKYDDKFLSSWQK 4xmd A 1.60 BS01 HEM A 1 E27 Y30 F41 F43 E56 L58 H60 F69 F88 Y107 V109 I121 I123 L135 E26 Y29 F40 F42 E55 L57 H59 F68 F87 Y106 V108 I120 I122 L134 1.7.6.1 26167269 PGECSVNVIPKKNLDKAKFFSGTWYETHYLDMDPQATEKFCFSFAPRESGGTVKEALYHFNVDSKVSFYNTGTGPLESNGAKYTAKFNTVDKKGKEIKPADEKYSYTVTVIEAAKQSALIHICLQEDGKDIGDLYSVLNRNKNALPNKKIKKALNKVSLVLTKFVVTKDLDCKYDDKFLSSWQK 4xme A 1.29 BS01 HEM A 1 E27 Y30 F41 F43 E56 L58 H60 F69 N71 F88 T90 Y107 V109 I121 I123 L135 S137 E26 Y29 F40 F42 E55 L57 H59 F68 N70 F87 T89 Y106 V108 I120 I122 L134 S136 1.7.6.1 26167269 PGECSVNVIPKKNLDKAKFFSGTWYETHYLDMDPQATEKFCFSFAPRESGGTVKEALYHFNVDSKVSFYNTGTGPLESNGAKYTAKFNTVDKKGKEIKPADEKYSYTVTVIEAAKQSALIHICLQEDGKDIGDLYSVLNRNKNALPNKKIKKALNKVSLVLTKFVVTKDLDCKYDDKFLSSWQK 4xmf A 1.60 BS01 HEM A 1 E27 Y30 F41 F43 E56 L58 H60 F69 F88 Y107 V109 I121 I123 L135 S137 E26 Y29 F40 F42 E55 L57 H59 F68 F87 Y106 V108 I120 I122 L134 S136 1.7.6.1 26167269 PGECSVNVIPKKNLDKAKFFSGTWYETHYLDMDPQATEKFCFSFAPRESGGTVKEALYHFNVDSKVSFYNTGTGPLESNGAKYTAKFNTVDKKGKEIKPADEKYSYTVTVIEAAKQSALIHICLQEDGKDIGDLYSVLNRNKNALPNKKIKKALNKVSLVLTKFVVTKDLDCKYDDKFLSSWQK 4xmf A 1.60 BS02 HSM A 1 D32 L125 G133 D134 D31 L124 G132 D133 1.7.6.1 26167269 PGECSVNVIPKKNLDKAKFFSGTWYETHYLDMDPQATEKFCFSFAPRESGGTVKEALYHFNVDSKVSFYNTGTGPLESNGAKYTAKFNTVDKKGKEIKPADEKYSYTVTVIEAAKQSALIHICLQEDGKDIGDLYSVLNRNKNALPNKKIKKALNKVSLVLTKFVVTKDLDCKYDDKFLSSWQK 4xmg A 1.80 BS01 HEM A 1 E27 Y30 F41 F43 F45 L58 H60 F69 F88 Y107 I121 I123 L135 S137 E26 Y29 F40 F42 F44 L57 H59 F68 F87 Y106 I120 I122 L134 S136 1.7.6.1 26167269 PGECSVNVIPKKNLDKAKFFSGTWYETHYLDMDPQATEKFCFSFAPRESGGTVKEALYHFNVDSKVSFYNTGTGPLESNGAKYTAKFNTVDKKGKEIKPADEKYSYTVTVIEAAKQSALIHICLQEDGKDIGDLYSVLNRNKNALPNKKIKKALNKVSLVLTKFVVTKDLDCKYDDKFLSSWQK 4xmg A 1.80 BS02 IMD A 1 I123 L125 L135 I122 L124 L134 1.7.6.1 26167269 PGECSVNVIPKKNLDKAKFFSGTWYETHYLDMDPQATEKFCFSFAPRESGGTVKEALYHFNVDSKVSFYNTGTGPLESNGAKYTAKFNTVDKKGKEIKPADEKYSYTVTVIEAAKQSALIHICLQEDGKDIGDLYSVLNRNKNALPNKKIKKALNKVSLVLTKFVVTKDLDCKYDDKFLSSWQK 4xmh A 1.29 BS01 III B 1 D32 I123 L125 G133 D134 D32 I123 L125 G133 D134 1.7.6.1 26167269 LPGECSVNVIPKKNLDKAKFFSGTWYETHYLDMDPQATEKFCFSFAPRESGGTVKEALYHFNVDSKVSFYNTGTGPLESNGAKYTAKFNTVDKKGKEIKPADEKYSYTVTVIEAAKQSALIHICLQEDGKDIGDLYSVLNRNKNALPNKKIKKALNKVSLVLTKFVVTKDLDCKYDDKFLSSWQK 4xmh A 1.29 BS02 HEM A 1 E27 Y30 F41 F43 E56 L58 H60 F69 N71 F88 Y107 V109 I121 I123 L135 S137 E27 Y30 F41 F43 E56 L58 H60 F69 N71 F88 Y107 V109 I121 I123 L135 S137 1.7.6.1 26167269 LPGECSVNVIPKKNLDKAKFFSGTWYETHYLDMDPQATEKFCFSFAPRESGGTVKEALYHFNVDSKVSFYNTGTGPLESNGAKYTAKFNTVDKKGKEIKPADEKYSYTVTVIEAAKQSALIHICLQEDGKDIGDLYSVLNRNKNALPNKKIKKALNKVSLVLTKFVVTKDLDCKYDDKFLSSWQK 4xqa A 1.41 BS01 ZN A 1 H231 E351 H50 E170 26177934 DTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqa A 1.41 BS02 423 B 1 Y308 Y312 P317 D318 P320 V322 K345 Y127 Y131 P136 D137 P139 V141 K164 26177934 DTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqa B 1.41 BS01 423 B 1 Y308 Y312 P317 D318 P320 V322 S344 K345 Y127 Y131 P136 D137 P139 V141 S163 K164 26177934 DTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqa B 1.41 BS02 ZN B 1 H231 E351 H50 E170 26177934 DTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqa C 1.41 BS01 423 B 1 Y308 Y312 P317 D318 V322 S344 K345 Y126 Y130 P135 D136 V140 S162 K163 26177934 TRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqb A 1.60 BS01 425 A 1 Y308 Y312 P317 P320 V322 S344 K345 Y127 Y131 P136 P139 V141 S163 K164 26177934 DTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqb A 1.60 BS02 ZN A 1 H231 E351 H50 E170 26177934 DTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqb A 1.60 BS03 ZN A 2 K236 E348 K55 E167 26177934 DTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqb B 1.60 BS01 425 A 1 Y308 Y312 P317 P320 S344 K345 Y128 Y132 P137 P140 S164 K165 26177934 YDTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqb B 1.60 BS02 ZN B 1 H231 E351 H51 E171 26177934 YDTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xqb C 1.60 BS01 425 A 1 Y308 Y312 P317 P320 S344 K345 Y127 Y131 P136 P139 S163 K164 26177934 DTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFSYIAQE 4xyy A 1.38 BS01 ZKG A 1 R45 N46 R45 N46 3.2.1.17 26179600 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 4xyy A 1.38 BS02 EDN A 1 S24 L25 G26 V120 Q121 I124 S24 L25 G26 V120 Q121 I124 3.2.1.17 26179600 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 4xyy A 1.38 BS03 EDN A 2 N46 T47 N46 T47 3.2.1.17 26179600 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 4xz1 A 2.80 BS01 III B 1 R17 R37 R41 H57 H58 F59 P60 I71 A72 G73 G74 Y87 D92 G93 L94 R170 R190 R192 Y209 H210 Y211 L212 I223 P224 E225 G226 T227 Y238 D244 G245 L246 R15 R35 R39 H55 H56 F57 P58 I69 A70 G71 G72 Y85 D90 G91 L92 R168 R188 R190 Y207 H208 Y209 L210 I221 P222 E223 G224 T225 Y236 D242 G243 L244 2.7.10.2 25287889 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDSLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPN 4xz1 A 2.80 BS02 4N6 A 1 N66 G67 T68 C78 N64 G65 T66 C76 2.7.10.2 25287889 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDSLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPN 4xz5 A 2.60 BS01 ZN A 1 H165 H167 H184 H91 H93 H110 4.2.1.1 PPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPD 4xz5 A 2.60 BS02 BCT A 1 H165 H184 L251 T252 H91 H110 L177 T178 4.2.1.1 PPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPD 4xz5 B 2.60 BS01 ZN B 1 H165 H167 H184 H91 H93 H110 4.2.1.1 PPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPD 4xz5 B 2.60 BS02 BCT B 1 H165 H184 L251 T252 H91 H110 L177 T178 4.2.1.1 PPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPD 4xz5 C 2.60 BS01 ZN C 1 H165 H167 H184 H91 H93 H110 4.2.1.1 PPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPD 4xz5 C 2.60 BS02 BCT C 1 H165 H184 L251 T252 H91 H110 L177 T178 4.2.1.1 PPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPD 4xz5 D 2.60 BS01 ZN D 1 H165 H167 H184 H91 H93 H110 4.2.1.1 PPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPD 4xz5 D 2.60 BS02 BCT D 1 H165 H167 H184 L251 T252 H91 H93 H110 L177 T178 4.2.1.1 PPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPD 4yg1 A 3.25 BS01 NUC F 1 R21 T27 Q28 Q39 A40 S43 N47 R21 T27 Q28 Q39 A40 S43 N47 MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg1 A 3.25 BS02 NUC T 1 I37 K38 T41 N44 N51 T52 T53 T56 I37 K38 T41 N44 N51 T52 T53 T56 MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg1 B 3.25 BS01 NUC F 1 I37 K38 T41 N51 T53 T56 I34 K35 T38 N48 T50 T53 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg1 B 3.25 BS02 NUC T 1 K18 R21 T27 Q28 S29 Q39 A40 S43 N47 K15 R18 T24 Q25 S26 Q36 A37 S40 N44 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg1 C 3.25 BS01 NUC F 1 K38 Q39 T41 N44 N51 T52 T53 T56 K35 Q36 T38 N41 N48 T49 T50 T53 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg1 C 3.25 BS02 NUC T 1 R21 T27 Q28 Q39 A40 S43 N47 R18 T24 Q25 Q36 A37 S40 N44 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg1 D 3.25 BS01 NUC F 1 R21 T27 Q28 S29 Q39 A40 S43 N47 R20 T26 Q27 S28 Q38 A39 S42 N46 MSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg1 D 3.25 BS02 NUC T 1 I37 K38 T41 N44 N51 T52 T53 T56 I36 K37 T40 N43 N50 T51 T52 T55 MSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg4 A 3.50 BS01 NUC T 1 I37 K38 T41 N48 N51 T52 T53 T56 I34 K35 T38 N45 N48 T49 T50 T53 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg4 A 3.50 BS02 NUC F 1 R21 T27 Q28 Q39 A40 S43 R18 T24 Q25 Q36 A37 S40 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg4 B 3.50 BS01 NUC T 1 R21 T27 Q28 S29 S43 N47 R18 T24 Q25 S26 S40 N44 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAK 4yg4 B 3.50 BS02 NUC F 1 I37 K38 Q39 T41 N44 N48 N51 T53 T56 I34 K35 Q36 T38 N41 N45 N48 T50 T53 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAK 4yg7 B 3.77 BS01 NUC R 1 R21 Q22 T27 Q28 S29 A40 S43 N47 R18 Q19 T24 Q25 S26 A37 S40 N44 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg7 B 3.77 BS02 NUC T 1 K38 T41 N51 T52 T53 T56 K35 T38 N48 T49 T50 T53 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg7 E 3.77 BS01 NUC R 1 I37 K38 T41 N44 N51 T53 T56 I34 K35 T38 N41 N48 T50 T53 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg7 E 3.77 BS02 NUC T 1 R21 Q28 Q39 S43 N47 R18 Q25 Q36 S40 N44 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCD 4yg7 C 3.77 BS01 NUC R 1 R21 T27 Q28 S29 Q39 A40 S43 N47 R18 T24 Q25 S26 Q36 A37 S40 N44 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAK 4yg7 C 3.77 BS02 NUC T 1 I37 K38 T41 N51 T52 T53 T56 I34 K35 T38 N48 T49 T50 T53 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAK 4yg7 G 3.77 BS01 NUC R 1 I37 K38 T41 N44 N51 T52 T53 T56 I34 K35 T38 N41 N48 T49 T50 T53 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAK 4yg7 G 3.77 BS02 NUC T 1 R21 T27 Q28 Q39 S43 N47 R18 T24 Q25 Q36 S40 N44 FQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAK 4yg7 K 3.77 BS01 NUC R 1 K379 R382 K354 R357 2.7.11.1 PKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYHAKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKARISVAGAQEKTALLRIGNDWCIPKGITPTTHIIKLPILSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRWNAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATQGHAKNFSVFIQAGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREY 4yj4 A 2.10 BS01 III B 1 A93 E96 F97 R100 Y101 A104 F105 Q111 L112 S122 Q125 V126 E129 L130 D133 N136 W137 G138 R139 Y195 A44 E47 F48 R51 Y52 A55 F56 Q62 L63 S73 Q76 V77 E80 L81 D84 N87 W88 G89 R90 Y146 26136077 GHMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEESAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYG 4ywt A 2.38 BS01 CA A 1 D388 D391 D332 D335 PASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMADRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNG 4ywt A 2.38 BS02 CA A 2 I437 E443 I375 E381 PASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMADRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNG 4ywt B 2.38 BS01 CA B 1 I437 E443 I393 E399 SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGND 4ywt B 2.38 BS02 CA B 2 D388 D391 D349 D352 SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGND 4ywt C 2.38 BS01 CA C 1 D48 E72 D20 E44 SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMARCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGN 4ywt C 2.38 BS02 CA C 2 I437 E443 I363 E369 SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMARCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGN 4ywt C 2.38 BS03 CA C 3 D388 D391 D321 D324 SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMARCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGN 4ywt D 2.38 BS01 CA D 1 I437 E443 I392 E398 SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMADRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGN 4ywt D 2.38 BS02 CA D 2 D388 D391 D349 D352 SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMADRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGN 4z5p A 1.90 BS01 HEM A 1 R65 I85 H93 R97 L152 F229 L233 A236 G237 T240 S241 Q244 A340 F341 H346 C348 L349 G350 L353 A354 R59 I74 H82 R86 L141 F218 L222 A225 G226 T229 S230 Q233 A329 F330 H335 C337 L338 G339 L342 A343 VHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGEGWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDRGRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITREKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQRLPIAW 4z5p B 1.90 BS01 HEM B 1 R65 I85 L86 H93 R97 I149 L152 F229 L233 A236 G237 T240 S241 Q244 A340 F341 G342 H346 C348 L349 G350 A354 R59 I74 L75 H82 R86 I138 L141 F218 L222 A225 G226 T229 S230 Q233 A329 F330 G331 H335 C337 L338 G339 A343 VHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGEGWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDRGRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITREKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQRLPIAW 4z7f A 3.19 BS01 FOL A 1 T32 L35 K36 D64 M68 A74 G75 Y76 F77 F80 T81 N117 T121 R142 K145 T26 L29 K30 D58 M62 A68 G69 Y70 F71 F74 T75 N111 T115 R136 K139 GTKSIALMGVLIAVVVVFSRFFAYETTFLKISFTFIPESLIGMIFGPFWAGIGTAVADVVGMLLFPKAGYFPGFTLNAFLAGAIYGYFYYKKEMTWQRVILATLLVTVLINIILTPLWLSLMYGVNLANFAWWVPRLIKTVIFFPIQVIATYYLGNKLFGKPL 4z7f B 3.19 BS01 FOL B 1 L35 K36 D64 M68 A74 G75 Y76 F77 F80 T81 N117 T121 R142 K145 L30 K31 D59 M63 A69 G70 Y71 F72 F75 T76 N112 T116 R137 K140 FGTKSIALMGVLIAVVVVFSRFFAYETTFLKISFTFIPESLIGMIFGPFWAGIGTAVADVVGMLLFPKAGYFPGFTLNAFLAGAIYGYFYYKKEMTWQRVILATLLVTVLINIILTPLWLSLMYGVNLANFAWWVPRLIKTVIFFPIQVIATYYLGNKIPLFGKPLSE 4z7f C 3.19 BS01 FOL C 1 R26 K36 D64 A74 G75 Y76 F77 F80 T81 N117 T121 L125 R142 K145 R20 K30 D58 A68 G69 Y70 F71 F74 T75 N111 T115 L119 R136 K139 GTKSIALMGVLIAVVVVFSRFFAYETTFLKISFTFIPESLIGMIFGPFWAGIGTAVADVVGMLLFPKAGYFPGFTLNAFLAGAIYGYFYYKKEMTWQRVILATLLVTVLINIILTPLWLSLMYGVNLANFAWWVPRLIKTVIFFPIQVIATYYLGNKFKRLFGKPL 4z7f D 3.19 BS01 FOL D 1 R26 T33 L35 K36 S38 D64 M68 A74 F80 N117 T121 K145 R21 T28 L30 K31 S33 D59 M63 A69 F75 N112 T116 K140 FGTKSIALMGVLIAVVVVFSRFFAYETTFLKISFTFIPESLIGMIFGPFWAGIGTAVADVVGMLLFPKAGYFPGFTLNAFLAGAIYGYFYYKKEMTWQRVILATLLVTVLINIILTPLWLSLMYGVNLANFAWWVPRLIKTVIFFPIQVIATYYLGNKFKFGKPSE 4z7f E 3.19 BS01 FOL E 1 T32 L35 K36 M68 A74 G75 Y76 F77 F80 N117 T121 T23 L26 K27 M59 A65 G66 Y67 F68 F71 N103 T107 SIALMGVLIAVVVVFSRFFAYETTFLKISFTFIPESLIGMIFGPFWAGIGTAVADVVGMLLFPKAGYFPGFTLNAFLAGAIYGYFKKWQRVILATLLVTVLINIILTPLWLSLMYNFAWWVPRLIKTVIFFPIQVIATYYLGNFGKP 4z7f F 3.19 BS01 FOL F 1 F34 L35 K36 S38 M68 K73 A74 F80 N117 T121 F28 L29 K30 S32 M62 K67 A68 F72 N105 T109 GTKSIALMGVLIAVVVVFSRFFAYETTFLKISFTFIPESLIGMIFGPFWAGIGTAVADVVGMLLFPKAFPGFTLNAFLAGAIYGYFYMTWQRVILATLLVTVLINIILTPLWLSLMYGNFAWWVPRLIKTVIFFPIQVIATYYLGNKLFG 4zcf A 2.60 BS01 NUC D 1 R305 Q319 H322 P324 K343 L346 K373 I374 R288 Q302 H305 P307 K326 L329 K356 I357 26067164 ANSKQLAVLKANFPQCFDKNGAFIQEKLLEIIRASEKESYSLNWLGKSYARLLANLPPKTLLAEDKTHNQQEENKNSQHLLIKGDNLEVLKHMVNAYAEKVKMIYIDPPYNTGKDGFVYNDDRFTPEQLSELAGIDLDEAKRILEFTTKGSSSHSAWLTFIYPRLYIARELMREDGTIFISIDHNEFSQLKLVCDEIFGEQNHVGDLVWKNATDNNPSNIAVEHEYIIVYTKNKEQLISEWKSNISDVKNLLVNIGEEFASKYTGNELQEKYTQWFREHRSELWPLDRYKYIDKDGIYTGSQSVHNPGKEGYRYDIIHPKTKKPCKQPLMGYRFPLDTMDRLLSEEKIIFGDDENKIIELKVYAKDYKQKLSSVIHLDGRVATNELKELFPMTQPFNAKTIKLVEDLISFACDGEGIVLDFFAGSGTTAHTVFNLNNKNKTSYQFITVQLDEPTKKSDAMKHGYNTIFDLTKERLIRASKKNRDQGFKVYQLMPDFRAKDESELTFFDDVVLTPEQYDTLLTTWCLYDGSLLTTPIEDVDLGGYKAHLCDGRLYLIAPNFTSEALKALLQKVDSDKDFAPNKVVFYGSNFSAKQMELNEALKSYANSIELDLVVRN 4zcf A 2.60 BS02 NUC E 1 W301 P302 R305 Y306 S320 N323 P324 Y329 R350 F351 P352 T355 Y384 W284 P285 R288 Y289 S303 N306 P307 Y312 R333 F334 P335 T338 Y367 26067164 ANSKQLAVLKANFPQCFDKNGAFIQEKLLEIIRASEKESYSLNWLGKSYARLLANLPPKTLLAEDKTHNQQEENKNSQHLLIKGDNLEVLKHMVNAYAEKVKMIYIDPPYNTGKDGFVYNDDRFTPEQLSELAGIDLDEAKRILEFTTKGSSSHSAWLTFIYPRLYIARELMREDGTIFISIDHNEFSQLKLVCDEIFGEQNHVGDLVWKNATDNNPSNIAVEHEYIIVYTKNKEQLISEWKSNISDVKNLLVNIGEEFASKYTGNELQEKYTQWFREHRSELWPLDRYKYIDKDGIYTGSQSVHNPGKEGYRYDIIHPKTKKPCKQPLMGYRFPLDTMDRLLSEEKIIFGDDENKIIELKVYAKDYKQKLSSVIHLDGRVATNELKELFPMTQPFNAKTIKLVEDLISFACDGEGIVLDFFAGSGTTAHTVFNLNNKNKTSYQFITVQLDEPTKKSDAMKHGYNTIFDLTKERLIRASKKNRDQGFKVYQLMPDFRAKDESELTFFDDVVLTPEQYDTLLTTWCLYDGSLLTTPIEDVDLGGYKAHLCDGRLYLIAPNFTSEALKALLQKVDSDKDFAPNKVVFYGSNFSAKQMELNEALKSYANSIELDLVVRN 4zcf A 2.60 BS03 MN A 1 H201 N202 H184 N185 26067164 ANSKQLAVLKANFPQCFDKNGAFIQEKLLEIIRASEKESYSLNWLGKSYARLLANLPPKTLLAEDKTHNQQEENKNSQHLLIKGDNLEVLKHMVNAYAEKVKMIYIDPPYNTGKDGFVYNDDRFTPEQLSELAGIDLDEAKRILEFTTKGSSSHSAWLTFIYPRLYIARELMREDGTIFISIDHNEFSQLKLVCDEIFGEQNHVGDLVWKNATDNNPSNIAVEHEYIIVYTKNKEQLISEWKSNISDVKNLLVNIGEEFASKYTGNELQEKYTQWFREHRSELWPLDRYKYIDKDGIYTGSQSVHNPGKEGYRYDIIHPKTKKPCKQPLMGYRFPLDTMDRLLSEEKIIFGDDENKIIELKVYAKDYKQKLSSVIHLDGRVATNELKELFPMTQPFNAKTIKLVEDLISFACDGEGIVLDFFAGSGTTAHTVFNLNNKNKTSYQFITVQLDEPTKKSDAMKHGYNTIFDLTKERLIRASKKNRDQGFKVYQLMPDFRAKDESELTFFDDVVLTPEQYDTLLTTWCLYDGSLLTTPIEDVDLGGYKAHLCDGRLYLIAPNFTSEALKALLQKVDSDKDFAPNKVVFYGSNFSAKQMELNEALKSYANSIELDLVVRN 4zcf B 2.60 BS01 NUC D 1 D123 P124 P125 Y126 D131 T230 N233 P234 S235 R397 T400 N416 K418 D120 P121 P122 Y123 D128 T227 N230 P231 S232 R392 T395 N411 K413 26067164 KKETIFEVETANSKQLAVLKANFPQCFDNGAFIQEKLLEIIRASEVELSKESYSLNWLGKSYARLLANLPPKTLLAEDKTHNQQEENKNSQHLLIKGDNLEVLKHMVNAYAEKVKMIYIDPPYNTGKDGFVYNDDRKFTPEQLSELAGIDLDEAKRILEFTTKGSSSHSAWLTFIYPRLYIARELMREDGTIFISIDHNEFSQLKLVCDEIFGEQNHVGDLVWKNATDNNPSNIAVEHEYIIVYTKKEQLISEWKSNISDVKNLLVNIGEEFASKYTGNELQEKYTQWFREHRSELWPLDRYKYIDKDGIYTGSQSVHNPGKEGYRYDIIHPKTKKPCKQPLMGYRFPLDTMDRLLSEEKIIFGDDEKIIELKVYAKDYKQKLSSVIHLDGRVATNELKELFPEMTQPFTNAKTIKLVEDLISFACDGEGIVLDFFAGSGTTAHTVFNLNNKNKTSYQFITVQLDEPTKDKSDAMKHGYNTIFDLTKERLIRASKKNRDQGFKVYQLMPDFVVLTPEQYDTLLTTWCLYDGSLLTTPIEDVDLGGYKAHLCDGRLYLIAPNFTALKALLQKDKDFAPNKVVFYGSNSAKQMELNEALKSYANKKELDLVVRN 4zcf B 2.60 BS02 NUC E 1 T230 N232 N233 P234 D395 R397 V398 T227 N229 N230 P231 D390 R392 V393 26067164 KKETIFEVETANSKQLAVLKANFPQCFDNGAFIQEKLLEIIRASEVELSKESYSLNWLGKSYARLLANLPPKTLLAEDKTHNQQEENKNSQHLLIKGDNLEVLKHMVNAYAEKVKMIYIDPPYNTGKDGFVYNDDRKFTPEQLSELAGIDLDEAKRILEFTTKGSSSHSAWLTFIYPRLYIARELMREDGTIFISIDHNEFSQLKLVCDEIFGEQNHVGDLVWKNATDNNPSNIAVEHEYIIVYTKKEQLISEWKSNISDVKNLLVNIGEEFASKYTGNELQEKYTQWFREHRSELWPLDRYKYIDKDGIYTGSQSVHNPGKEGYRYDIIHPKTKKPCKQPLMGYRFPLDTMDRLLSEEKIIFGDDEKIIELKVYAKDYKQKLSSVIHLDGRVATNELKELFPEMTQPFTNAKTIKLVEDLISFACDGEGIVLDFFAGSGTTAHTVFNLNNKNKTSYQFITVQLDEPTKDKSDAMKHGYNTIFDLTKERLIRASKKNRDQGFKVYQLMPDFVVLTPEQYDTLLTTWCLYDGSLLTTPIEDVDLGGYKAHLCDGRLYLIAPNFTALKALLQKDKDFAPNKVVFYGSNSAKQMELNEALKSYANKKELDLVVRN 4zcf C 2.60 BS01 NUC D 1 N192 R230 K235 K236 T237 N177 R215 K220 K221 T222 26067164 TLEKNLPHQKAGVDAVMNVFVSATPHLTDNVAVRLLANPELKLSEQQYYNNIKNVQAFNGIAHSKDNHNAKSNIIDVSMETGTGKTYTYIKTIFDLNKSFGINKFIIIVPTLSIKAGTVNFLKSDALKEHFRDDYKRELRTYVVESQKMPQAIHDFVEASNFKKYIHVLVINSGMINSKSLTDTYDTGLLDNQFNTPVDALRAVKPFIIIDEPHRFPTGKKTWENIEKFNAQYIIRYGATFSEGYKNLVYRLTAVDAFNDDLVKGIDAYIEDNANLKFVKDGKEATFFKLAKSLSKTHSAIHDLTLDALNTAVLSNGIELKIGSSINPYSYDQTLADNMMRKAVKEHFKLEKELLTQPRIKPLTLFFIDDLKTKFEEYVLAEANELLYKNYLEKTVTNISSVHGGYIEQEINEILHDKELLLSLDNPRRFIFSKWTLREGWDNPNVFQICKLRSSKLQEVGRGLRLPVNEYMCRVKNFTLKYYVDFTEKDFVDSLVKEVNESSPSKFTQELKEQIDNFKDSDAYSRLKSELKELWDLINQKAVIEYKINSESEFLSIFKSFMLEETERSYREFLDNLSQTIFVKHGTLHKVFCDIKDTILNIQTIRKIKSGFSKYLLNNSFSLGYNL 4zcf C 2.60 BS02 NUC E 1 T116 L117 S151 N187 G189 M190 S193 K194 S195 G352 I353 E354 S359 T503 T111 L112 S146 N172 G174 M175 S178 K179 S180 G317 I318 E319 S324 T436 26067164 TLEKNLPHQKAGVDAVMNVFVSATPHLTDNVAVRLLANPELKLSEQQYYNNIKNVQAFNGIAHSKDNHNAKSNIIDVSMETGTGKTYTYIKTIFDLNKSFGINKFIIIVPTLSIKAGTVNFLKSDALKEHFRDDYKRELRTYVVESQKMPQAIHDFVEASNFKKYIHVLVINSGMINSKSLTDTYDTGLLDNQFNTPVDALRAVKPFIIIDEPHRFPTGKKTWENIEKFNAQYIIRYGATFSEGYKNLVYRLTAVDAFNDDLVKGIDAYIEDNANLKFVKDGKEATFFKLAKSLSKTHSAIHDLTLDALNTAVLSNGIELKIGSSINPYSYDQTLADNMMRKAVKEHFKLEKELLTQPRIKPLTLFFIDDLKTKFEEYVLAEANELLYKNYLEKTVTNISSVHGGYIEQEINEILHDKELLLSLDNPRRFIFSKWTLREGWDNPNVFQICKLRSSKLQEVGRGLRLPVNEYMCRVKNFTLKYYVDFTEKDFVDSLVKEVNESSPSKFTQELKEQIDNFKDSDAYSRLKSELKELWDLINQKAVIEYKINSESEFLSIFKSFMLEETERSYREFLDNLSQTIFVKHGTLHKVFCDIKDTILNIQTIRKIKSGFSKYLLNNSFSLGYNL 4zcf C 2.60 BS03 AMP C 1 Q14 G89 K90 T91 Y92 I119 G122 T123 F126 D226 D509 R537 Q9 G84 K85 T86 Y87 I114 G117 T118 F121 D211 D442 R465 26067164 TLEKNLPHQKAGVDAVMNVFVSATPHLTDNVAVRLLANPELKLSEQQYYNNIKNVQAFNGIAHSKDNHNAKSNIIDVSMETGTGKTYTYIKTIFDLNKSFGINKFIIIVPTLSIKAGTVNFLKSDALKEHFRDDYKRELRTYVVESQKMPQAIHDFVEASNFKKYIHVLVINSGMINSKSLTDTYDTGLLDNQFNTPVDALRAVKPFIIIDEPHRFPTGKKTWENIEKFNAQYIIRYGATFSEGYKNLVYRLTAVDAFNDDLVKGIDAYIEDNANLKFVKDGKEATFFKLAKSLSKTHSAIHDLTLDALNTAVLSNGIELKIGSSINPYSYDQTLADNMMRKAVKEHFKLEKELLTQPRIKPLTLFFIDDLKTKFEEYVLAEANELLYKNYLEKTVTNISSVHGGYIEQEINEILHDKELLLSLDNPRRFIFSKWTLREGWDNPNVFQICKLRSSKLQEVGRGLRLPVNEYMCRVKNFTLKYYVDFTEKDFVDSLVKEVNESSPSKFTQELKEQIDNFKDSDAYSRLKSELKELWDLINQKAVIEYKINSESEFLSIFKSFMLEETERSYREFLDNLSQTIFVKHGTLHKVFCDIKDTILNIQTIRKIKSGFSKYLLNNSFSLGYNL 4zck A 2.48 BS01 MG A 1 N485 D573 N182 D269 GSTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTGKKLTNMRASTDEAVVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRANRA 4zck A 2.48 BS02 MG A 2 G481 E570 I572 G178 E266 I268 GSTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTGKKLTNMRASTDEAVVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRANRA 4zcl A 3.06 BS01 GDP A 1 H13 D15 G17 K18 T19 T20 N128 K129 D131 S166 A167 L168 H13 D15 G17 K18 T19 T20 N104 K105 D107 S142 A143 L144 MIEKLRNIAIIAHVDHGKTTLVDKLLQQSGTILAKNTAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGLDHEDMAEDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIGRIKRGKVKPNQQVTIIDSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIVAITGLGELNISDTVCDTQNVEALPALSVDEPTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRAN 4zcl B 3.06 BS01 GDP B 1 D15 G17 K18 T19 T20 N128 K129 D131 S166 A167 L168 D15 G17 K18 T19 T20 N104 K105 D107 S142 A143 L144 MIEKLRNIAIIAHVDHGKTTLVDKLLQQSGTILAKNTAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGLDHEDMAEDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIGRIKRGKVKPNQQVTIIDSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIVAITGLGELNISDTVCDTQNVEALPALSVDEPTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRAN 4zcm A 3.31 BS01 G4P A 1 H13 V14 D15 H16 G17 K18 T19 T20 N128 K129 D131 S166 A167 L168 H13 V14 D15 H16 G17 K18 T19 T20 N104 K105 D107 S142 A143 L144 MIEKLRNIAIIAHVDHGKTTLVDKLLQQSGTILAKNTAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGLDHEDMAEDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIGRIKRGKVKPNQQVTIIDSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIVAITGLGELNISDTVCDTQNVEALPALSVDEPTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRAN 4zcm B 3.31 BS01 G4P B 1 V14 D15 H16 G17 K18 T19 T20 K129 D131 A167 L168 V14 D15 H16 G17 K18 T19 T20 K105 D107 A143 L144 MIEKLRNIAIIAHVDHGKTTLVDKLLQQSGTILAKNTAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGLDHEDMAEDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIGRIKRGKVKPNQQVTIIDSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIVAITGLGELNISDTVCDTQNVEALPALSVDEPTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRAN 4zkp A 2.10 BS01 CA A 1 N63 Q66 N9 Q12 GAYDAQVKNDEQDVELADHEARIKQLRIDVDDHESRITANTKAITALNVRVTTAEGEIASLQTNVSALDGRVTTAENNISALQADYVSKTATTSQSLASPLNVTTSYSVGGKKVLGARQTGWTAATGTANKGVFDADLTFAVSDTYTQSEIQAIANALITERRRTKAMEDALRAHGLID 4zkp B 2.10 BS01 CA B 1 N63 Q66 N9 Q12 GAYDAQVKNDEQDVELADHEARIKQLRIDVDDHESRITANTKAITALNVRVTTAEGEIASLQTNVSALDGRVTTAENNISALQADYVSKTATTSQSLASPLNVTTSYSVGGKKVLGARQTGWTAATGTANKGVFDADLTFAVSDTYTQSEIQAIANALITERRRTKAMEDALRAHGLID 4zr0 A 3.80 BS01 ZN A 1 H271 H326 H330 H345 H349 H155 H210 H214 H229 H233 1.-.-.- FDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSK 4zr0 A 3.80 BS02 ZN A 2 H244 H249 H268 H272 H348 H128 H133 H152 H156 H232 1.-.-.- FDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSK 4zr0 B 3.80 BS01 ZN B 1 H271 H326 H330 H345 H349 H153 H208 H212 H227 H231 1.-.-.- STTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYESGLE 4zr0 B 3.80 BS02 ZN B 2 H244 H249 H268 H272 H348 H126 H131 H150 H154 H230 1.-.-.- STTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYESGLE 4zr1 A 2.60 BS01 ZN A 1 H271 H326 H330 H345 H349 H155 H210 H214 H229 H233 1.-.-.- FDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYESGLEVL 4zr1 A 2.60 BS02 ZN A 2 H244 H249 H268 H272 H348 H128 H133 H152 H156 H232 1.-.-.- FDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYESGLEVL 4zr1 B 2.60 BS01 ZN B 1 H271 H326 H330 H345 H349 H155 H210 H214 H229 H233 1.-.-.- FDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYESGLEVLF 4zr1 B 2.60 BS02 ZN B 2 H244 H249 H268 H272 H348 H128 H133 H152 H156 H232 1.-.-.- FDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYESGLEVLF 4ztc A 2.00 BS01 4RA A 1 F4 P7 P8 S55 A56 T57 T81 F82 A84 D155 A157 E158 S179 N181 G182 N183 R329 W332 F4 P7 P8 S55 A56 T57 T81 F82 A84 D155 A157 E158 S179 N181 G182 N183 R329 W332 26178292 MRFFLSPPHMGGNELKYIEEVFKSNYIAPLGEFVNRFEQSVKDYSKSENALALNSATAALHLALRVAGVKQDDIVLASSFTFIASVAPICYLKAKPVFIDCDETYNIDVDLLKLAIKECEKKPKALILTHLYGNAAKMDEIVEICKENDIVLIEDAAEALGSFYKNKALGTFGEFGVYSYNGNAIITTSGGGMLIGKNKEKIEKARFYSTQARENCLHYEHLDYGYNYRLSNVLGAIGVAQMEVLEQRVLKKREIYEWYKEFLGEYFSFLDELENSRSNRWLSTALINFDKNELNSCQKDINISQKNITLHPKISKLIEDLKNKQIETRPLWKTMHAQEVFKGAKAYLNGNSELFFQKGICLPSGTAMSKDDVYEISKLILKSIK 4zum A 1.42 BS01 ZN A 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zum A 1.42 BS02 FKS A 1 P156 H158 H159 G167 Y168 C169 D195 H197 F225 D284 I291 E320 G321 Y323 P156 H158 H159 G167 Y168 C169 D195 H197 F225 D284 I291 E320 G321 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zum B 1.42 BS01 ZN B 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zum B 1.42 BS02 FKS B 1 P156 H158 H159 G167 Y168 C169 D195 H197 F225 D284 I291 E320 G321 Y323 P156 H158 H159 G167 Y168 C169 D195 H197 F225 D284 I291 E320 G321 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zun A 1.40 BS01 SS9 A 1 Y19 H158 H159 G167 Y168 D195 H197 F225 D284 I291 G321 Y323 Y19 H158 H159 G167 Y168 D195 H197 F225 D284 I291 G321 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zun A 1.40 BS02 ZN A 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zun A 1.40 BS03 ZN A 2 H158 H159 H158 H159 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zun A 1.40 BS04 SS9 B 1 Y83 E106 Y83 E106 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zun B 1.40 BS01 SS9 A 1 Y83 E106 Y83 E106 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zun B 1.40 BS02 ZN B 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zun B 1.40 BS03 ZN B 2 H158 H159 H158 H159 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zun B 1.40 BS04 SS9 B 1 H158 H159 G167 Y168 D195 F225 I291 G321 Y323 H158 H159 G167 Y168 D195 F225 I291 G321 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zuo A 1.33 BS01 ZN A 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zuo A 1.33 BS02 XS6 A 1 Y19 H158 H159 G167 Y168 D195 H197 F225 D284 I291 Y323 Y19 H158 H159 G167 Y168 D195 H197 F225 D284 I291 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zuo B 1.33 BS01 ZN B 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zuo B 1.33 BS02 XS6 B 1 Y19 H158 H159 G167 Y168 D195 H197 F225 I291 Y323 Y19 H158 H159 G167 Y168 D195 H197 F225 I291 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zup A 1.42 BS01 ZN A 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zup A 1.42 BS02 5XA A 1 E117 H158 H159 Y168 D195 H197 F225 D284 Y323 E117 H158 H159 Y168 D195 H197 F225 D284 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zup B 1.42 BS01 ZN B 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zup B 1.42 BS02 5XA B 1 E117 H158 H159 G167 Y168 D195 H197 F225 D284 I291 Y323 E117 H158 H159 G167 Y168 D195 H197 F225 D284 I291 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zuq A 1.22 BS01 6XA A 1 E17 E117 H158 H159 Y168 D195 H197 F225 D284 Y323 E17 E117 H158 H159 Y168 D195 H197 F225 D284 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zuq A 1.22 BS02 ZN A 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zuq B 1.22 BS01 6XA B 1 E17 E117 H158 H159 Y168 D195 H197 F225 D284 Y323 E17 E117 H158 H159 Y168 D195 H197 F225 D284 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zuq B 1.22 BS02 ZN B 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zur A 1.13 BS01 ZN A 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zur A 1.13 BS02 7XA A 1 L18 Y19 E117 H158 H159 G167 Y168 D195 H197 F225 D284 I291 Y323 L18 Y19 E117 H158 H159 G167 Y168 D195 H197 F225 D284 I291 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zur B 1.13 BS01 ZN B 1 D195 H197 D284 D195 H197 D284 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zur B 1.13 BS02 7XA B 1 L18 Y19 E117 H158 H159 G167 Y168 D195 H197 F225 D284 I291 Y323 L18 Y19 E117 H158 H159 G167 Y168 D195 H197 F225 D284 I291 Y323 MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG 4zyf A 1.80 BS01 4T4 A 1 Q24 L54 F55 L57 G58 I61 M62 Y67 Q72 F86 F91 V93 I99 Y100 Q7 L37 F38 L40 G41 I44 M45 Y50 Q55 F69 F74 V76 I82 Y83 6.3.2.- 26181851 QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV 4zyi A 1.67 BS01 4TH A 1 Q24 L54 F55 L57 G58 I61 M62 Y67 Q72 F86 F91 V93 H96 I99 Y100 Q5 L34 F35 L37 G38 I41 M42 Y47 Q52 F66 F71 V73 H76 I79 Y80 6.3.2.- 26181851 PASEQETLVRPKPLLLKLLKSVGQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV 4zyr A 3.31 BS01 9PG A 1 M23 R144 G147 C148 W151 E269 N272 H322 M18 R139 G142 C143 W146 E248 N251 H301 26157133 NTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTWIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFWYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSL 4zyr B 3.31 BS01 9PG B 1 F20 F27 F118 R144 G147 C148 W151 E269 N272 F15 F22 F113 R139 G142 C143 W146 E246 N249 26157133 NTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTWIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFWYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSL 5a0u A 2.40 BS01 CHT A 1 Y490 D498 T616 G617 F677 G770 C771 E773 T784 Y788 L980 Y154 D162 T280 G281 F341 G434 C435 E437 T448 Y452 L644 26187464 MEGLTPRMQRLRNHYLTVRPSVSIYRALAFTEVVKANPGMPTILLRAKAFRHACETAPILIQDDELIVGHPCGKPRAGAFSPDIAWRWVRDELDTMSTRPQDPFEISEADKKTIREEIVPFWEGRSLDEICEAQYREAGVWAFSGETFVSDLSYHQINGGGDTCPGYDVLLFTKGMNGIKADAEAHLASLSMENPEDIDRIYYYKAAIETCEGVVNYARRIAAHARELAAKEQNAQRRAELLTIAEVNENVPANPPKTLQEALQSIWTVESLFEIEENQTGLSLGRVDQYCYPMFEADIREGRLTHDTALELLQAFIIKCAELMWMSSELGAKYFAGYQPFINLTVGGQKRSGGDACNDLTYLIMDAVRFVKVYQPSLACRIHNQSPQKYMEKIVDVVKAGMGFPACHFDDSHIKMMLRKGFDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLNRGRMVLFDSYQGLDTGDLRDLRTFDEFDAAVKQQIAHIVRLSAIGTVISQRVHRDVAPKPLMSLLVEGCMESGKDVAAGGAMVNHGPGLIFSGLATYVDSMAAIRKLVFEEKKYTLEQIRDALLANFEGYEALRRDCLNAPKYGNDDNYVDQYALDITEWTEKECRKYKMLYSTLSHGTLSISNNTPIGELTNATPNGRLAWMPLSDGISPTQGADKQGPTAIIKSVSKMNVETMNIGMVHNFKFLKGLLDTPEGRHGLITLLRTASILGNGQMQFSYVDNEVLKKAQQEPEKYRDLIVRVAGYSAYFVELCKEVQDEIISRTVIEKF 5a0u B 2.40 BS01 CHT B 1 Y490 D498 G617 F671 G770 C771 E773 T784 Y788 L980 Y155 D163 G282 F336 G435 C436 E438 T449 Y453 L645 26187464 VMEGLTPRMQRLRNHYLTVRPSVSIYRALAFTEVVKANPGMPTILLRAKAFRHACETAPILIQDDELIVGHPCGKPRAGAFSPDIAWRWVRDELDTMSTRPQDPFEISEADKKTIREEIVPFWEGRSLDEICEAQYREAGVWAFSGETFVSDLSYHQINGGGDTCPGYDVLLFTKGMNGIKADAEAHLASLSMENPEDIDRIYYYKAAIETCEGVVNYARRIAAHARELAAKEQNAQRRAELLTIAEVNENVPANPPKTLQEALQSIWTVESLFEIEENQTGLSLGRVDQYCYPMFEADIREGRLTHDTALELLQAFIIKCAELMWMSSELGAKYFAGYQPFINLTVGGQKRSGGDACNDLTYLIMDAVRFVKVYQPSLACRIHNQSPQKYMEKIVDVVKAGMGFPACHFDDSHIKMMLRKGFDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLNRGRMVLFDSYQGLDTGDLRDLRTFDEFDAAVKQQIAHIVRLSAIGTVISQRVHRDVAPKPLMSLLVEGCMESGKDVAAGGAMVNHGPGLIFSGLATYVDSMAAIRKLVFEEKKYTLEQIRDALLANFEGYEALRRDCLNAPKYGNDDNYVDQYALDITEWTEKECRKYKMLYSTLSHGTLSISNNTPIGELTNATPNGRLAWMPLSDGISPTQGADKQGPTAIIKSVSKMNVETMNIGMVHNFKFLKGLLDTPEGRHGLITLLRTASILGNGQMQFSYVDNEVLKKAQQEPEKYRDLIVRVAGYSAYFVELCKEVQDEIISRTVIEKF 5a0u C 2.40 BS01 CHT C 1 Y490 D498 T616 G617 F677 G770 C771 E773 T784 Y788 L980 I982 Y155 D163 T281 G282 F342 G435 C436 E438 T449 Y453 L645 I647 26187464 VMEGLTPRMQRLRNHYLTVRPSVSIYRALAFTEVVKANPGMPTILLRAKAFRHACETAPILIQDDELIVGHPCGKPRAGAFSPDIAWRWVRDELDTMSTRPQDPFEISEADKKTIREEIVPFWEGRSLDEICEAQYREAGVWAFSGETFVSDLSYHQINGGGDTCPGYDVLLFTKGMNGIKADAEAHLASLSMENPEDIDRIYYYKAAIETCEGVVNYARRIAAHARELAAKEQNAQRRAELLTIAEVNENVPANPPKTLQEALQSIWTVESLFEIEENQTGLSLGRVDQYCYPMFEADIREGRLTHDTALELLQAFIIKCAELMWMSSELGAKYFAGYQPFINLTVGGQKRSGGDACNDLTYLIMDAVRFVKVYQPSLACRIHNQSPQKYMEKIVDVVKAGMGFPACHFDDSHIKMMLRKGFDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLNRGRMVLFDSYQGLDTGDLRDLRTFDEFDAAVKQQIAHIVRLSAIGTVISQRVHRDVAPKPLMSLLVEGCMESGKDVAAGGAMVNHGPGLIFSGLATYVDSMAAIRKLVFEEKKYTLEQIRDALLANFEGYEALRRDCLNAPKYGNDDNYVDQYALDITEWTEKECRKYKMLYSTLSHGTLSISNNTPIGELTNATPNGRLAWMPLSDGISPTQGADKQGPTAIIKSVSKMNVETMNIGMVHNFKFLKGLLDTPEGRHGLITLLRTASILGNGQMQFSYVDNEVLKKAQQEPEKYRDLIVRVAGYSAYFVELCKEVQDEIISRTVIEKF 5a0u D 2.40 BS01 CHT D 1 Y490 D498 T616 F671 G770 C771 E773 T784 Y788 I982 Y155 D163 T281 F336 G435 C436 E438 T449 Y453 I647 26187464 VMEGLTPRMQRLRNHYLTVRPSVSIYRALAFTEVVKANPGMPTILLRAKAFRHACETAPILIQDDELIVGHPCGKPRAGAFSPDIAWRWVRDELDTMSTRPQDPFEISEADKKTIREEIVPFWEGRSLDEICEAQYREAGVWAFSGETFVSDLSYHQINGGGDTCPGYDVLLFTKGMNGIKADAEAHLASLSMENPEDIDRIYYYKAAIETCEGVVNYARRIAAHARELAAKEQNAQRRAELLTIAEVNENVPANPPKTLQEALQSIWTVESLFEIEENQTGLSLGRVDQYCYPMFEADIREGRLTHDTALELLQAFIIKCAELMWMSSELGAKYFAGYQPFINLTVGGQKRSGGDACNDLTYLIMDAVRFVKVYQPSLACRIHNQSPQKYMEKIVDVVKAGMGFPACHFDDSHIKMMLRKGFDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLNRGRMVLFDSYQGLDTGDLRDLRTFDEFDAAVKQQIAHIVRLSAIGTVISQRVHRDVAPKPLMSLLVEGCMESGKDVAAGGAMVNHGPGLIFSGLATYVDSMAAIRKLVFEEKKYTLEQIRDALLANFEGYEALRRDCLNAPKYGNDDNYVDQYALDITEWTEKECRKYKMLYSTLSHGTLSISNNTPIGELTNATPNGRLAWMPLSDGISPTQGADKQGPTAIIKSVSKMNVETMNIGMVHNFKFLKGLLDTPEGRHGLITLLRTASILGNGQMQFSYVDNEVLKKAQQEPEKYRDLIVRVAGYSAYFVELCKEVQDEIISRTVIEKF 5a0u E 2.40 BS01 CHT E 1 Y490 D498 G617 G770 C771 E773 T784 Y788 L980 I982 Y155 D163 G282 G435 C436 E438 T449 Y453 L645 I647 26187464 VMEGLTPRMQRLRNHYLTVRPSVSIYRALAFTEVVKANPGMPTILLRAKAFRHACETAPILIQDDELIVGHPCGKPRAGAFSPDIAWRWVRDELDTMSTRPQDPFEISEADKKTIREEIVPFWEGRSLDEICEAQYREAGVWAFSGETFVSDLSYHQINGGGDTCPGYDVLLFTKGMNGIKADAEAHLASLSMENPEDIDRIYYYKAAIETCEGVVNYARRIAAHARELAAKEQNAQRRAELLTIAEVNENVPANPPKTLQEALQSIWTVESLFEIEENQTGLSLGRVDQYCYPMFEADIREGRLTHDTALELLQAFIIKCAELMWMSSELGAKYFAGYQPFINLTVGGQKRSGGDACNDLTYLIMDAVRFVKVYQPSLACRIHNQSPQKYMEKIVDVVKAGMGFPACHFDDSHIKMMLRKGFDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLNRGRMVLFDSYQGLDTGDLRDLRTFDEFDAAVKQQIAHIVRLSAIGTVISQRVHRDVAPKPLMSLLVEGCMESGKDVAAGGAMVNHGPGLIFSGLATYVDSMAAIRKLVFEEKKYTLEQIRDALLANFEGYEALRRDCLNAPKYGNDDNYVDQYALDITEWTEKECRKYKMLYSTLSHGTLSISNNTPIGELTNATPNGRLAWMPLSDGISPTQGADKQGPTAIIKSVSKMNVETMNIGMVHNFKFLKGLLDTPEGRHGLITLLRTASILGNGQMQFSYVDNEVLKKAQQEPEKYRDLIVRVAGYSAYFVELCKEVQDEIISRTVIEKF 5a0u F 2.40 BS01 CHT F 1 Y490 D498 G617 F671 F677 G770 C771 E773 T784 Y788 Y155 D163 G282 F336 F342 G435 C436 E438 T449 Y453 26187464 VMEGLTPRMQRLRNHYLTVRPSVSIYRALAFTEVVKANPGMPTILLRAKAFRHACETAPILIQDDELIVGHPCGKPRAGAFSPDIAWRWVRDELDTMSTRPQDPFEISEADKKTIREEIVPFWEGRSLDEICEAQYREAGVWAFSGETFVSDLSYHQINGGGDTCPGYDVLLFTKGMNGIKADAEAHLASLSMENPEDIDRIYYYKAAIETCEGVVNYARRIAAHARELAAKEQNAQRRAELLTIAEVNENVPANPPKTLQEALQSIWTVESLFEIEENQTGLSLGRVDQYCYPMFEADIREGRLTHDTALELLQAFIIKCAELMWMSSELGAKYFAGYQPFINLTVGGQKRSGGDACNDLTYLIMDAVRFVKVYQPSLACRIHNQSPQKYMEKIVDVVKAGMGFPACHFDDSHIKMMLRKGFDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLNRGRMVLFDSYQGLDTGDLRDLRTFDEFDAAVKQQIAHIVRLSAIGTVISQRVHRDVAPKPLMSLLVEGCMESGKDVAAGGAMVNHGPGLIFSGLATYVDSMAAIRKLVFEEKKYTLEQIRDALLANFEGYEALRRDCLNAPKYGNDDNYVDQYALDITEWTEKECRKYKMLYSTLSHGTLSISNNTPIGELTNATPNGRLAWMPLSDGISPTQGADKQGPTAIIKSVSKMNVETMNIGMVHNFKFLKGLLDTPEGRHGLITLLRTASILGNGQMQFSYVDNEVLKKAQQEPEKYRDLIVRVAGYSAYFVELCKEVQDEIISRTVIEKF 5a0u G 2.40 BS01 CHT G 1 Y490 D498 T616 G617 F677 M769 G770 C771 E773 T784 Y788 I982 Y155 D163 T281 G282 F342 M434 G435 C436 E438 T449 Y453 I647 26187464 VMEGLTPRMQRLRNHYLTVRPSVSIYRALAFTEVVKANPGMPTILLRAKAFRHACETAPILIQDDELIVGHPCGKPRAGAFSPDIAWRWVRDELDTMSTRPQDPFEISEADKKTIREEIVPFWEGRSLDEICEAQYREAGVWAFSGETFVSDLSYHQINGGGDTCPGYDVLLFTKGMNGIKADAEAHLASLSMENPEDIDRIYYYKAAIETCEGVVNYARRIAAHARELAAKEQNAQRRAELLTIAEVNENVPANPPKTLQEALQSIWTVESLFEIEENQTGLSLGRVDQYCYPMFEADIREGRLTHDTALELLQAFIIKCAELMWMSSELGAKYFAGYQPFINLTVGGQKRSGGDACNDLTYLIMDAVRFVKVYQPSLACRIHNQSPQKYMEKIVDVVKAGMGFPACHFDDSHIKMMLRKGFDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLNRGRMVLFDSYQGLDTGDLRDLRTFDEFDAAVKQQIAHIVRLSAIGTVISQRVHRDVAPKPLMSLLVEGCMESGKDVAAGGAMVNHGPGLIFSGLATYVDSMAAIRKLVFEEKKYTLEQIRDALLANFEGYEALRRDCLNAPKYGNDDNYVDQYALDITEWTEKECRKYKMLYSTLSHGTLSISNNTPIGELTNATPNGRLAWMPLSDGISPTQGADKQGPTAIIKSVSKMNVETMNIGMVHNFKFLKGLLDTPEGRHGLITLLRTASILGNGQMQFSYVDNEVLKKAQQEPEKYRDLIVRVAGYSAYFVELCKEVQDEIISRTVIEKF 5a0u H 2.40 BS01 CHT H 1 Y490 D498 G617 G770 C771 E773 T784 L980 I982 Y157 D165 G284 G437 C438 E440 T451 L647 I649 26187464 TPVMEGLTPRMQRLRNHYLTVRPSVSIYRALAFTEVVKANPGMPTILLRAKAFRHACETAPILIQDDELIVGHPCGKPRAGAFSPDIAWRWVRDELDTMSTRPQDPFEISEADKKTIREEIVPFWEGRSLDEICEAQYREAGVWAFSGETFVSDLSYHQINGGGDTCPGYDVLLFTKGMNGIKADAEAHLASLSMENPEDIDRIYYYKAAIETCEGVVNYARRIAAHARELAAKEQNAQRRAELLTIAEVNENVPANPPKTLQEALQSIWTVESLFEIEENQTGLSLGRVDQYCYPMFEADIREGRLTHDTALELLQAFIIKCAELMWMSSELGAKYFAGYQPFINLTVGGQKRSGGDACNDLTYLIMDAVRFVKVYQPSLACRIHNQSPQKYMEKIVDVVKAGMGFPACHFDDSHIKMMLRKGFDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLNRGRMVLFDSYQGLDTGDLRDLRTFDEFDAAVKQQIAHIVRLSAIGTVISQRVHRDVAPKPLMSLLVEGCMESGKDVAAGGAMVNHGPGLIFSGLATYVDSMAAIRKLVFEEKKYTLEQIRDALLANFEGYEALRRDCLNAPKYGNDDNYVDQYALDITEWTEKECRKYKMLYSTLSHGTLSISNNTPIGELTNATPNGRLAWMPLSDGISPTQGADKQGPTAIIKSVSKMNVETMNIGMVHNFKFLKGLLDTPEGRHGLITLLRTASILGNGQMQFSYVDNEVLKKAQQEPEKYRDLIVRVAGYSAYFVELCKEVQDEIISRTVIEKF 5a3a A 1.54 BS01 GLY A 1 T153 Y154 K155 T147 Y148 K149 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3a A 1.54 BS02 GLY A 2 R192 E200 F204 K208 R186 E194 F198 K202 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3a A 1.54 BS03 GLY A 3 W243 R263 W237 R257 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3a A 1.54 BS04 ZN A 1 C145 C149 C180 C183 C139 C143 C174 C177 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3b A 1.90 BS01 GLY A 1 D72 F73 D75 W76 Y79 D66 F67 D69 W70 Y73 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3b A 1.90 BS02 ALA A 1 Q236 H240 Q230 H234 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3b A 1.90 BS03 ZN A 1 C145 C149 C180 C183 C139 C143 C174 C177 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3b A 1.90 BS04 APR A 1 G33 A34 G35 A39 L66 T117 Q137 G229 V230 G231 T233 T234 N258 H259 K260 Y262 H278 I279 G27 A28 G29 A33 L60 T111 Q131 G223 V224 G225 T227 T228 N252 H253 K254 Y256 H272 I273 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3c A 2.03 BS01 GLY A 1 Y60 Q61 F62 F71 Y54 Q55 F56 F65 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3c A 2.03 BS02 GLY A 2 D75 W76 Q77 D69 W70 Q71 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3c A 2.03 BS03 GLY A 3 K110 D111 Y112 N132 F214 K104 D105 Y106 N126 F208 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3c A 2.03 BS04 ZN A 1 C145 C149 C180 C183 C139 C143 C174 C177 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5a3c A 2.03 BS05 NAD A 1 G33 A34 G35 A39 Y44 L66 T117 N118 A119 D120 Q137 Y140 G229 V230 G231 H232 T233 T234 N258 H259 K260 Y262 H278 I279 G27 A28 G29 A33 Y38 L60 T111 N112 A113 D114 Q131 Y134 G223 V224 G225 H226 T227 T228 N252 H253 K254 Y256 H272 I273 2.4.2.30 26166706 NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK 5aku A 1.80 BS01 29F A 1 H1031 G1032 S1033 P1034 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 P83 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5aku A 1.80 BS02 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5aku B 1.80 BS01 29F B 1 H1031 G1032 S1033 P1034 F1035 A1049 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 P83 F84 A98 Y99 Y109 F110 A111 K116 S117 Y120 I124 E185 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5aku B 1.80 BS02 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5akw A 2.07 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5akw A 2.07 BS02 NKI A 1 H1031 G1032 S1033 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E185 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5akw B 2.07 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5akw B 2.07 BS02 NKI B 1 H1031 G1032 S1033 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al1 A 1.75 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al1 A 1.75 BS02 GN5 A 1 H1031 G1032 P1034 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H80 G81 P83 F84 Y99 Y109 F110 A111 K116 S117 Y120 E185 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al1 B 1.75 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al1 B 1.75 BS02 GN5 B 1 H1031 G1032 S1033 P1034 F1035 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 P83 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al2 A 1.90 BS01 O53 A 1 H1031 G1032 S1033 F1035 A1049 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 A98 Y99 Y109 F110 A111 K116 S117 Y120 I124 E185 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al2 A 1.90 BS02 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al2 B 1.90 BS01 O53 B 1 H1031 G1032 F1035 A1049 Y1050 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 F84 A98 Y99 Y109 F110 A111 K116 S117 Y120 I124 E186 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al2 B 1.90 BS02 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al3 A 1.75 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al3 A 1.75 BS02 TGW A 1 H1031 G1032 P1034 F1035 H1048 Y1050 G1058 I1059 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 P83 F84 H97 Y99 G107 I108 Y109 F110 A111 K116 S117 Y120 I124 E185 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al3 B 1.75 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al3 B 1.75 BS02 TGW B 1 H1031 G1032 P1034 F1035 H1048 Y1050 I1059 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H80 G81 P83 F84 H97 Y99 I108 Y109 F110 A111 K116 S117 Y120 E186 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al4 A 1.90 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al4 A 1.90 BS02 WLH A 1 H1031 G1032 S1033 Y1050 Y1060 A1062 S1068 Y1071 I1075 E1138 H80 G81 S82 Y99 Y109 A111 S117 Y120 I124 E185 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al4 B 1.90 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al4 B 1.90 BS02 WLH B 1 H1031 G1032 S1033 Y1050 Y1060 A1062 S1068 Y1071 I1075 H80 G81 S82 Y99 Y109 A111 S117 Y120 I124 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al5 A 2.05 BS01 ZN A 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al5 A 2.05 BS02 JL9 A 1 H1031 G1032 S1033 F1035 A1049 Y1050 Y1060 A1062 K1067 S1068 Y1071 I1075 E1138 H80 G81 S82 F84 A98 Y99 Y109 A111 K116 S117 Y120 I124 E185 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al5 B 2.05 BS01 ZN B 1 C1081 H1084 C1089 C1092 C130 H133 C138 C141 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5al5 B 2.05 BS02 JL9 B 1 H1031 G1032 S1033 F1035 A1049 Y1050 Y1060 A1062 S1068 Y1071 I1075 H80 G81 S82 F84 A98 Y99 Y109 A111 S117 Y120 I124 2.4.2.30 26183543 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5bmf H 2.80 BS01 4TJ H 1 A197 N199 Y251 R253 W351 D353 F397 A34 N36 Y51 R53 W99 D101 F103 26176812 QVQLQESGPGLVKPSQTLSLTCTVSGYSITSDYAWNWIRQHPGKGLEWIGYIRYSGHTGYNPSLKSRVTISRDTSKNQFSLKLSSVTAADTAVYYCARWVDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 5bmf L 2.80 BS01 4TJ H 1 Y581 Y597 Y751 G753 Y798 Y31 Y37 Y94 G96 Y101 26176812 DVVMTQSPLSLPVTLGQPASISCRSSQSIVYNNRYTYLEWFQQRPGQSPRLLIYGVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCYQGTHAPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 5boo A 2.80 BS01 D65 A 1 L172 L176 G181 E182 C184 H185 F188 L197 F227 L240 I263 R265 I272 L531 V532 M536 L11 L15 G20 E21 C23 H24 F27 L36 F66 L79 I102 R104 I111 L340 V341 M345 1.3.5.2 26180101 NPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDEFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRK 5boo A 2.80 BS02 FMN A 1 A224 A225 G226 K229 T249 I263 I272 N274 C276 K429 S457 N458 T459 S477 G478 L481 S505 G506 G507 Y528 S529 A63 A64 G65 K68 T88 I102 I111 N113 C115 K238 S266 N267 T268 S286 G287 L290 S314 G315 G316 Y337 S338 1.3.5.2 26180101 NPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDEFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRK 5boo B 2.80 BS01 D65 B 1 L172 L176 G181 E182 C184 H185 F188 L197 F227 L240 I263 R265 I272 L531 V532 M536 L11 L15 G20 E21 C23 H24 F27 L36 F66 L79 I102 R104 I111 L340 V341 M345 1.3.5.2 26180101 NPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDEFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGR 5boo B 2.80 BS02 FMN B 1 A224 A225 G226 K229 T249 I263 I272 N274 C276 K429 S457 N458 T459 S477 G478 L481 S505 G506 G507 Y528 S529 A63 A64 G65 K68 T88 I102 I111 N113 C115 K238 S266 N267 T268 S286 G287 L290 S314 G315 G316 Y337 S338 1.3.5.2 26180101 NPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDEFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGR 5bsz A 2.00 BS01 SAH A 1 L13 G14 L19 A53 H59 E74 L75 S76 A95 D96 M97 F98 L112 T113 S115 Y118 L15 G16 L21 A55 H61 E76 L77 S78 A97 D98 M99 F100 L114 T115 S117 Y120 26177844 GHMAVGSTSVYGDALGEVYDLFYRGRGKDFAAEAEWVRRVVRERRPGARSLLDVACGTGEHLAHLVEHFPDAAGVELSPAMRAAAERKLTATPVHQADMFDFDLGRVFDAVCCLTGSIAYAADTAELARAVRAMARHLPVGGVLVIDPWWSPGTFLDGHIAHDVVEGEGRTVVRLSRSHRIGDVSRHEAHYLAADATGVRHFSQVQDLTLFPAEDYLAALAAAGCEPEHLTDVGQPRRGLFVGVRRE 5bsz A 2.00 BS02 THM A 1 W148 T152 F153 L154 H157 S176 H185 R235 W150 T154 F155 L156 H159 S178 H187 R237 26177844 GHMAVGSTSVYGDALGEVYDLFYRGRGKDFAAEAEWVRRVVRERRPGARSLLDVACGTGEHLAHLVEHFPDAAGVELSPAMRAAAERKLTATPVHQADMFDFDLGRVFDAVCCLTGSIAYAADTAELARAVRAMARHLPVGGVLVIDPWWSPGTFLDGHIAHDVVEGEGRTVVRLSRSHRIGDVSRHEAHYLAADATGVRHFSQVQDLTLFPAEDYLAALAAAGCEPEHLTDVGQPRRGLFVGVRRE 5bt9 A 1.50 BS01 NAP A 1 G19 R23 I24 H42 C43 N44 R45 S46 A69 D70 L71 E72 N95 A96 S97 I145 I146 D147 Y160 K164 P189 G190 T192 L193 G14 R18 I19 H37 C38 N39 R40 S41 A64 D65 L66 E67 N90 A91 S92 I140 I141 D142 Y155 K159 P184 G185 T187 L188 EARMVANCPVLVTGGARRIGKAIVEDLASHGFPVAIHCNRSLDEGEAIANRINDSGGNACVVQADLEGDVRGLVKQASDRIGPIRLLVNNASLFQEDKVGALDMALWDRHFAVHLKTPVILAEDMRKALPEDQDGLVVNIIDQRVWKLNPQFFSYTLSKTALWNATRTLAQALAPRIRVNAIAPGPTLPSERQRPEDFERQVSKLPLQRAPELPEFGRTVRYFWENRSITGQMIALDGGQHLAWETPDI 5bt9 B 1.50 BS01 NAP B 1 G19 R23 I24 H42 C43 N44 R45 S46 A69 D70 L71 E72 N95 A96 S97 I145 I146 D147 Y160 K164 P189 G190 T192 G13 R17 I18 H36 C37 N38 R39 S40 A63 D64 L65 E66 N89 A90 S91 I139 I140 D141 Y154 K158 P183 G184 T186 ARMVANCPVLVTGGARRIGKAIVEDLASHGFPVAIHCNRSLDEGEAIANRINDSGGNACVVQADLEGDVRGLVKQASDRIGPIRLLVNNASLFQEDKVGALDMALWDRHFAVHLKTPVILAEDMRKALPEDQDGLVVNIIDQRVWKLNPQFFSYTLSKTALWNATRTLAQALAPRIRVNAIAPGPTLPSRPEDFERQVSKLPLQRAPELPEFGRTVRYFWENRSITGQMIALDGGQHLAWETPDIAE 5bt9 C 1.50 BS01 NAP C 1 R23 I24 H42 C43 N44 R45 S46 A69 L71 E72 N95 A96 S97 V118 I145 I146 Y160 K164 P189 G190 T192 L193 R18 I19 H37 C38 N39 R40 S41 A64 L66 E67 N90 A91 S92 V113 I140 I141 Y155 K159 P184 G185 T187 L188 EARMVANCPVLVTGGARRIGKAIVEDLASHGFPVAIHCNRSLDEGEAIANRINDSGGNACVVQADLEGDVRGLVKQASDRIGPIRLLVNNASLFQEDKVGALDMALWDRHFAVHLKTPVILAEDMRKALPEDQDGLVVNIIDQRVWKLNPQFFSYTLSKTALWNATRTLAQALAPRIRVNAIAPGPTLPSERQRPEDFERQVSKLPLQRAPELPEFGRTVRYFWENRSITGQMIALDGGQHLAWETPDIA 5bt9 D 1.50 BS01 NAP D 1 G19 R23 I24 H42 C43 N44 R45 S46 A69 D70 L71 E72 N95 A96 S97 I145 I146 D147 Y160 K164 P189 G190 T192 G12 R16 I17 H35 C36 N37 R38 S39 A62 D63 L64 E65 N88 A89 S90 I138 I139 D140 Y153 K157 P182 G183 T185 RMVANCPVLVTGGARRIGKAIVEDLASHGFPVAIHCNRSLDEGEAIANRINDSGGNACVVQADLEGDVRGLVKQASDRIGPIRLLVNNASLFQEDKVGALDMALWDRHFAVHLKTPVILAEDMRKALPEDQDGLVVNIIDQRVWKLNPQFFSYTLSKTALWNATRTLAQALAPRIRVNAIAPGPTLPPEDFERQVSKLPLQRAPELPEFGRTVRYFWENRSITGQMIALDGGQHLAWETPDIAE 5by0 A 1.80 BS01 MG A 1 D254 N255 D292 D251 N252 D289 2.1.1.- GHMTIPGRFMTIDKGTFGEYTASTRWPIIIQNAIDDLSKHQETEKSNGTKFEQGEVIKKELKEFRQEIIDRVPLRPFTEEEIKIANVPLSFNEYLKKHPEVNWGAVEWLFSEVYLYRRVNVLFQRQCEWAKFDIFNRLKQSTFESSFYGVVELALRYENLLPQLREMKQNDDILKVLFKEFIEISLWGNATDLSLLTNATLEDIKSIQGAKARAASESKIVVNDTEKAWEVLTKARADANSREIRVDFVLDNSGFELYADLMLAAFLLQSGLATKCIFHAKDIPYMVSDVMLKDFDILVHDLRDREFFPSGEPSTKESRALDLFAGEMEKFVSSGKIEFREDSFWTTELDYWNLDANETKYHGSILHKDLQKSNLVIFKGDLNYRKLTGDRKWPRTTKWETAIGPLATNGITSLSLRTCKADVQVALPEGLDAKLSQEWEKENPGRGSWWCCSGKWAVICFCSGI 5c0w G 4.60 BS01 NUC N 1 T79 K108 T77 K106 TFIFPGDSFPVDPTTPVKLGPGIYCDPNTQEIRPVNTGVLHVSAKGKSGVQTAYIDYSSKRYIPSVNDFVIGVIIGTFSDSYKVSLQNFSSSVSLSYMAFPNASKKNRPTLQVGDLVYARVCTAEKELEAEIECFDSTTGRDAGFGILEDGMIIDVNLNFARQLLFNNDFPLLKVLAAHTKFEVAIGLNGKIWVKCEELSNTLACYRTIMECCQKNDTAAFKDIAKRQFKEILTVK 5c0w J 4.60 BS01 NUC R 1 N277 R397 D543 P544 C547 D549 I550 N551 Y595 Y654 L696 V727 E728 M731 L732 N735 R753 H755 T810 M813 M814 A815 A816 H831 G833 L834 Y839 H841 T843 S844 R847 R882 R889 R896 N259 R366 D512 P513 C516 D518 I519 N520 Y564 Y623 L665 V696 E697 M700 L701 N704 R722 H724 T779 M782 M783 A784 A785 H800 G802 L803 Y808 H810 T812 S813 R816 R851 R858 R865 3.1.13.-,3.1.26.- RRKRLADGLSVTQKVFVRSRNGGATKIVREHYLRSDIPCLSRSCTKCPQIVVPDAQNELPKFILSDSPLELSAPIGKHYVVLDTNVVLQAIDLLENPNCFFDVIVPQIVLDEVRNKSYPVYTRLRTLCRDSDDHKRFIVFHNEFSEHTFVERLPNETINDRNNRAIRKTCQWYSEHLKPYDINVVLVTNDRLNREAATKEVESNIITKSLVQYIELLPNADDIRDSIPQMTFSDFTFPEYYSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLIVGQKNLNRAFNGDQVIVELLPQSEWKAPSSIVLDSEHFDVNDNPDINTTVISDKQRRLLAKDAMIAQRSKKIQPTAKVVYIQRRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLDKRIVISIDSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFSKKVLECLPAEGHDWKAPTKLDDPEAVSKDPLLTKRKDLRDKLICSIDPPGCVDINDALHAKKLPNGNWEVGVHIADVTHFVKPGTALDAEGAARGTSVYLVDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVIRSREAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNLASPEVKVHMDSETSDPNEVEIKKLLATNSLVEEFMLLANISVARKIYDAFPQTAMLRRHAAPPSTNFEILNEMLNTRKNMSISLESSKALADSLDRCVDPEDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHFTSPIRRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGRASIEYYVGQVMRNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTEDPNSAAFDEVEYKLTFVPTNSDKPRDVYVFDKVEVQVRSVMDPITSKRKAELLLK 5c0w J 4.60 BS02 MG J 1 D543 D552 D512 D521 3.1.13.-,3.1.26.- RRKRLADGLSVTQKVFVRSRNGGATKIVREHYLRSDIPCLSRSCTKCPQIVVPDAQNELPKFILSDSPLELSAPIGKHYVVLDTNVVLQAIDLLENPNCFFDVIVPQIVLDEVRNKSYPVYTRLRTLCRDSDDHKRFIVFHNEFSEHTFVERLPNETINDRNNRAIRKTCQWYSEHLKPYDINVVLVTNDRLNREAATKEVESNIITKSLVQYIELLPNADDIRDSIPQMTFSDFTFPEYYSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLIVGQKNLNRAFNGDQVIVELLPQSEWKAPSSIVLDSEHFDVNDNPDINTTVISDKQRRLLAKDAMIAQRSKKIQPTAKVVYIQRRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLDKRIVISIDSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFSKKVLECLPAEGHDWKAPTKLDDPEAVSKDPLLTKRKDLRDKLICSIDPPGCVDINDALHAKKLPNGNWEVGVHIADVTHFVKPGTALDAEGAARGTSVYLVDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVIRSREAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNLASPEVKVHMDSETSDPNEVEIKKLLATNSLVEEFMLLANISVARKIYDAFPQTAMLRRHAAPPSTNFEILNEMLNTRKNMSISLESSKALADSLDRCVDPEDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHFTSPIRRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGRASIEYYVGQVMRNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTEDPNSAAFDEVEYKLTFVPTNSDKPRDVYVFDKVEVQVRSVMDPITSKRKAELLLK 5c0w J 4.60 BS03 ZN J 1 C47 C52 C55 H184 C39 C44 C47 H176 3.1.13.-,3.1.26.- RRKRLADGLSVTQKVFVRSRNGGATKIVREHYLRSDIPCLSRSCTKCPQIVVPDAQNELPKFILSDSPLELSAPIGKHYVVLDTNVVLQAIDLLENPNCFFDVIVPQIVLDEVRNKSYPVYTRLRTLCRDSDDHKRFIVFHNEFSEHTFVERLPNETINDRNNRAIRKTCQWYSEHLKPYDINVVLVTNDRLNREAATKEVESNIITKSLVQYIELLPNADDIRDSIPQMTFSDFTFPEYYSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLIVGQKNLNRAFNGDQVIVELLPQSEWKAPSSIVLDSEHFDVNDNPDINTTVISDKQRRLLAKDAMIAQRSKKIQPTAKVVYIQRRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLDKRIVISIDSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFSKKVLECLPAEGHDWKAPTKLDDPEAVSKDPLLTKRKDLRDKLICSIDPPGCVDINDALHAKKLPNGNWEVGVHIADVTHFVKPGTALDAEGAARGTSVYLVDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVIRSREAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNLASPEVKVHMDSETSDPNEVEIKKLLATNSLVEEFMLLANISVARKIYDAFPQTAMLRRHAAPPSTNFEILNEMLNTRKNMSISLESSKALADSLDRCVDPEDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHFTSPIRRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGRASIEYYVGQVMRNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTEDPNSAAFDEVEYKLTFVPTNSDKPRDVYVFDKVEVQVRSVMDPITSKRKAELLLK 5c0w K 4.60 BS01 NUC N 1 Y315 S327 Q345 L346 Y361 Y276 S288 Q306 L307 Y322 3.1.13.- NPDVLLSRVINVVRAASSLASQDVDFYKNLDRGFSKDLKSKADKLADMANEIILSIDWNNFGNIMDNLLEMSDHSLDKLNCAINSKTKRVEKPQLKFKSPIDNSESHPFIPLLKEKPNALKPLSESLRLVDDDENNPSHYPHPYEYEIDHQEYSPEILQIREEIPSKSWDDSVPIWVDTSTELESMLEDLKNTKEIAVDLEHHDYRSYYGIVCLMQISTRERDYLVDTLKLRENLHILNEVFTNPSIVKVFHGAFMNIIWLQRDLGLYVVGLFDTYHASKAIGLPRHSLAYLLENFANFKTSKKYQLADWRIRPLSKPMTAYARADTHFLLNIYDQLRNKLIESNKLAGVLYESRNVAKRRFEYSKYRPLTPSSEVYSPIEKESPWKILMYQYNIPPEREVLVRELYQWRDLIARRDDESPRFVMPNQLLAALVAYTPTDVIGVVSLTNGVTEHVRQNAKLLANLIRDALRNIKNTNEEATPIPSSETKADGILLETISVPQIRDVMERFSVLCNSNISKSRAKPVTNSSILLGKILPREEHDIAYSKDGLPNKVKTEDIRIRAQNFKSALANLED 5c1z A 1.79 BS01 ZN A 1 C150 C154 C212 H215 C90 C94 C152 H155 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z A 1.79 BS02 ZN A 2 C166 C169 C196 C201 C106 C109 C136 C141 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z A 1.79 BS03 ZN A 3 C238 C241 C260 C263 C178 C181 C200 C203 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z A 1.79 BS04 ZN A 4 C253 H257 C289 C293 C193 H197 C229 C233 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z A 1.79 BS05 ZN A 5 C332 C337 C352 G361 C272 C277 C292 G296 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z A 1.79 BS06 ZN A 6 C365 C368 H373 C377 C300 C303 H308 C312 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z A 1.79 BS07 ZN A 7 C418 C421 C436 C441 C337 C340 C355 C360 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z A 1.79 BS08 ZN A 8 C446 C449 C457 H461 C365 C368 C376 H380 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z B 1.79 BS01 ZN B 1 C150 C154 C212 H215 C90 C94 C152 H155 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z B 1.79 BS02 ZN B 2 C166 C169 C196 C201 C106 C109 C136 C141 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z B 1.79 BS03 ZN B 3 C238 C241 C260 C263 C178 C181 C200 C203 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z B 1.79 BS04 ZN B 4 C253 H257 C289 C293 C193 H197 C229 C233 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z B 1.79 BS05 ZN B 5 C332 C337 C352 G361 C272 C277 C292 G296 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z B 1.79 BS06 ZN B 6 C365 C368 H373 C377 C300 C303 H308 C312 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z B 1.79 BS07 ZN B 7 C418 C421 C436 C441 C337 C340 C355 C360 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c1z B 1.79 BS08 ZN B 8 C446 C449 C457 H461 C365 C368 C376 H380 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 A 2.37 BS01 ZN A 1 C150 C154 C212 H215 C90 C94 C152 H155 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 A 2.37 BS02 ZN A 2 C166 C169 C196 C201 C106 C109 C136 C141 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 A 2.37 BS03 ZN A 3 C238 C241 C260 C263 C178 C181 C200 C203 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 A 2.37 BS04 ZN A 4 C253 H257 C289 C293 C193 H197 C229 C233 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 A 2.37 BS05 ZN A 5 C332 C337 C352 C272 C277 C292 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 A 2.37 BS06 ZN A 6 C365 C368 H373 C377 C300 C303 H308 C312 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 A 2.37 BS07 ZN A 7 C418 C421 C436 C441 C337 C340 C355 C360 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 A 2.37 BS08 ZN A 8 C446 C449 C457 H461 C365 C368 C376 H380 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 B 2.37 BS01 ZN B 1 C150 C154 C212 H215 C90 C94 C152 H155 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 B 2.37 BS02 ZN B 2 C166 C169 C196 C201 C106 C109 C136 C141 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 B 2.37 BS03 ZN B 3 C238 C241 C260 C263 C178 C181 C200 C203 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 B 2.37 BS04 ZN B 4 C253 H257 C289 C293 C193 H197 C229 C233 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 B 2.37 BS05 ZN B 5 C332 C337 C352 C272 C277 C292 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 B 2.37 BS06 ZN B 6 C365 C368 H373 C377 C300 C303 H308 C312 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 B 2.37 BS07 ZN B 7 C418 C421 C436 C441 C337 C340 C355 C360 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c23 B 2.37 BS08 ZN B 8 C446 C449 C457 H461 C365 C368 C376 H380 6.3.2.- MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQDIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFCRECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 5c24 A 2.60 BS01 4XO A 1 L100 K101 K103 V179 Y181 Y188 G190 F227 W229 L234 H235 P236 Y318 L98 K99 K101 V177 Y179 Y186 G188 F221 W223 L228 H229 P230 Y310 3.4.23.16,2.7.7.49,2.7.7.7,3.1.26.13,3.1.13.2 26166629 MVPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFAAQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPAKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGN 5c24 A 2.60 BS02 MG A 1 K73 Y146 Q151 K71 Y144 Q149 3.4.23.16,2.7.7.49,2.7.7.7,3.1.26.13,3.1.13.2 26166629 MVPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFAAQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPAKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGN 5c25 A 2.84 BS01 639 A 1 P95 L100 K101 K103 Y181 Y188 F227 W229 L234 H235 Y318 P97 L102 K103 K105 Y183 Y190 F229 W231 L236 H237 Y320 3.4.23.16,2.7.7.49,2.7.7.7,3.1.26.13,3.1.13.2 26166629 MVPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFAAQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLV 5c25 A 2.84 BS02 MG A 1 D443 D498 Q547 D445 D500 Q549 3.4.23.16,2.7.7.49,2.7.7.7,3.1.26.13,3.1.13.2 26166629 MVPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFAAQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLV 5c6s A 1.30 BS01 4K8 A 1 Y1096 Y1099 F1147 D1149 Y18 Y21 F69 D71 EDSPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKVQG 5cd6 A 2.26 BS01 CA A 1 D232 T233 D211 T212 QTTGVVCEEFDQIQLTHVLTPTGPLPTALDPNGVYPYMSYSETSNRPVPKRYRMISLENEKVKAIICPDLCGKVISLTHKESGKEVLYRPDVIKYTRILPRFYFVAGGIEVSFPISHSPTQNEPVLYQIDHTGDRTYVTCGERESHYGMQWSVEYSLGDKDECLTQRVVYYNPGKQAYPWMSWSNAALPCAPDTQYDFPNGTVLSHASTLDTIDWKTEGTHHERDIKEMTGYFWKTKDVNAFGAYTPSLGSGLYHIADESSTPGIKLWSYGVAGDKEWSMLSTPDRQPYVEIQGGPISDQSIKLELRPGEKKNHVEYWIPTDHPLDIYSLKVPALRLRPIDRIPLFDWARKNESSIWIALADAYKNKSTLPAAPYPEDGQWAPSGMEDLDDAFRWAIQISPRPERDYWQFHYGTWLAGRERVEEAIEQLSIPDIDLAKALLARLYVRRQAWEKARDTYAAIPETSWLNLHPQLVIERDKVLKKFGTEALPEREKWLDKINASSDEWVVERKVQLLIDKKQYQEAKDLLLSTHFQKVHQTYTRTGLWEQINEGLGLSPQPVPEQLGEDRLARFEYE 5cd6 A 2.26 BS02 CA A 2 D306 Q308 D285 Q287 QTTGVVCEEFDQIQLTHVLTPTGPLPTALDPNGVYPYMSYSETSNRPVPKRYRMISLENEKVKAIICPDLCGKVISLTHKESGKEVLYRPDVIKYTRILPRFYFVAGGIEVSFPISHSPTQNEPVLYQIDHTGDRTYVTCGERESHYGMQWSVEYSLGDKDECLTQRVVYYNPGKQAYPWMSWSNAALPCAPDTQYDFPNGTVLSHASTLDTIDWKTEGTHHERDIKEMTGYFWKTKDVNAFGAYTPSLGSGLYHIADESSTPGIKLWSYGVAGDKEWSMLSTPDRQPYVEIQGGPISDQSIKLELRPGEKKNHVEYWIPTDHPLDIYSLKVPALRLRPIDRIPLFDWARKNESSIWIALADAYKNKSTLPAAPYPEDGQWAPSGMEDLDDAFRWAIQISPRPERDYWQFHYGTWLAGRERVEEAIEQLSIPDIDLAKALLARLYVRRQAWEKARDTYAAIPETSWLNLHPQLVIERDKVLKKFGTEALPEREKWLDKINASSDEWVVERKVQLLIDKKQYQEAKDLLLSTHFQKVHQTYTRTGLWEQINEGLGLSPQPVPEQLGEDRLARFEYE 5cm6 A 1.83 BS01 PYR A 1 F43 Y95 Y96 Q152 R173 P175 W211 E235 T238 L240 F18 Y70 Y71 Q127 R148 P150 W186 E210 T213 L215 KKYRWRLAETWGPNFPIFGDASKNMAKMVKEMSDGRLTIRIDSANKHKSALGIFDFVKSGQYQMGHSASYYWKGKDFNTMFFTTVPFGMTAPEQYAWFYYGGGMELMKETYDQYGILSFPGGNTGVQMGGWFRKEINTVEDLKGLKMRIPGFAGEVLAKLGASPTNIPSAELYTALERNTIDALEWVGPSLDLRMGFHKIAPYYYTGWQEPATELQFMVNQKAYDSLPADLQKILTVAMKTAAYDMYSQSTHENGVNLKALQSEYPNVKIRTFPQPVMNAIRDANDELLAEFAAKDKETAKILKSIKTYQEQVRAWTKFADQAYLESFESN 5cm6 A 1.83 BS02 NA A 1 Y95 Q152 R173 E210 W211 E235 Y70 Q127 R148 E185 W186 E210 KKYRWRLAETWGPNFPIFGDASKNMAKMVKEMSDGRLTIRIDSANKHKSALGIFDFVKSGQYQMGHSASYYWKGKDFNTMFFTTVPFGMTAPEQYAWFYYGGGMELMKETYDQYGILSFPGGNTGVQMGGWFRKEINTVEDLKGLKMRIPGFAGEVLAKLGASPTNIPSAELYTALERNTIDALEWVGPSLDLRMGFHKIAPYYYTGWQEPATELQFMVNQKAYDSLPADLQKILTVAMKTAAYDMYSQSTHENGVNLKALQSEYPNVKIRTFPQPVMNAIRDANDELLAEFAAKDKETAKILKSIKTYQEQVRAWTKFADQAYLESFESN 5cm6 B 1.83 BS01 PYR B 1 F43 Y95 Y96 Q152 R173 P175 E210 W211 E235 T238 L240 F18 Y70 Y71 Q127 R148 P150 E185 W186 E210 T213 L215 KKYRWRLAETWGPNFPIFGDASKNMAKMVKEMSDGRLTIRIDSANKHKSALGIFDFVKSGQYQMGHSASYYWKGKDFNTMFFTTVPFGMTAPEQYAWFYYGGGMELMKETYDQYGILSFPGGNTGVQMGGWFRKEINTVEDLKGLKMRIPGFAGEVLAKLGASPTNIPSAELYTALERNTIDALEWVGPSLDLRMGFHKIAPYYYTGWQEPATELQFMVNQKAYDSLPADLQKILTVAMKTAAYDMYSQSTHENGVNLKALQSEYPNVKIRTFPQPVMNAIRDANDELLAEFAAKDKETAKILKSIKTYQEQVRAWTKFADQAYLESFE 5cm6 B 1.83 BS02 NA B 1 Y95 Q152 R173 E210 W211 E235 Y70 Q127 R148 E185 W186 E210 KKYRWRLAETWGPNFPIFGDASKNMAKMVKEMSDGRLTIRIDSANKHKSALGIFDFVKSGQYQMGHSASYYWKGKDFNTMFFTTVPFGMTAPEQYAWFYYGGGMELMKETYDQYGILSFPGGNTGVQMGGWFRKEINTVEDLKGLKMRIPGFAGEVLAKLGASPTNIPSAELYTALERNTIDALEWVGPSLDLRMGFHKIAPYYYTGWQEPATELQFMVNQKAYDSLPADLQKILTVAMKTAAYDMYSQSTHENGVNLKALQSEYPNVKIRTFPQPVMNAIRDANDELLAEFAAKDKETAKILKSIKTYQEQVRAWTKFADQAYLESFE 5cnn A 1.90 BS01 ANP A 1 G695 S696 G697 A698 G700 V702 A719 K721 Q767 L768 M769 C773 D813 R817 N818 L820 D831 G21 S22 G23 A24 G26 V28 A45 K47 Q90 L91 M92 C96 D136 R140 N141 L143 D154 2.7.10.1 26124280 PNQALLRQLKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 5cnn A 1.90 BS02 MG A 1 N818 D831 N141 D154 2.7.10.1 26124280 PNQALLRQLKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 5cnn B 1.90 BS01 ANP B 1 G695 S696 G697 A698 F699 G700 V702 A719 K721 Q767 L768 M769 C773 D813 R817 N818 L820 D831 G20 S21 G22 A23 F24 G25 V27 A44 K46 Q92 L93 M94 C98 D138 R142 N143 L145 D156 2.7.10.1 26124280 NQALLRQLKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 5cnn B 1.90 BS02 MG B 1 N818 D831 N143 D156 2.7.10.1 26124280 NQALLRQLKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 5cno A 1.55 BS01 ANP A 1 L694 G695 S696 G697 A698 G700 V702 A719 K721 Q767 M769 C773 D813 R817 N818 L820 D831 L19 G20 S21 G22 A23 G25 V27 A44 K46 Q87 M89 C93 D133 R137 N138 L140 D151 2.7.10.1 26124280 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADE 5cno A 1.55 BS02 MG A 1 N818 D831 N138 D151 2.7.10.1 26124280 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADE 5cno B 1.55 BS01 ANP B 1 G695 S696 G697 A698 F699 V702 A719 K721 Q767 M769 C773 D813 R817 N818 L820 D831 G22 S23 G24 A25 F26 V29 A46 K48 Q90 M92 C96 D136 R140 N141 L143 D154 2.7.10.1 26124280 APNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADE 5cno B 1.55 BS02 MG B 1 N818 D831 N141 D154 2.7.10.1 26124280 APNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADE 5cnp B 2.38 BS01 MG B 1 E33 E75 E32 E74 2.3.1.57 NSQLTLRALERGDLRFIHNLNNNRNIMSYWFEEPYESFDELEELYNKHIHDNAERRFVVEDAQKNLIGLVELIEINYIHRSAEFQIIIAPEHQGKGFARTLINRALDYSFTILNLHKIYLHVAVENPKAVHLYEECGFVEEGHLVEEFFINGRYQDVKRMYILQSKYLNRS 5cnp D 2.38 BS01 MG D 1 E33 E75 E35 E77 2.3.1.57 NAMNSQLTLRALERGDLRFIHNLNNNRNIMSYWFEEPYESFDELEELYNKHIHDNAERRFVVEDAQKNLIGLVELIEINYIHRSAEFQIIIAPEHQGKGFARTLINRALDYSFTILNLHKIYLHVAVENPKAVHLYEECGFVEEGHLVEEFFINGRYQDVKRMYILQSKYLNRSE 5cnp F 2.38 BS01 MG F 1 E33 E75 E32 E74 2.3.1.57 NSQLTLRALERGDLRFIHNLNNNRNIMSYWFEEPYESFDELEELYNKHIHDNAERRFVVEDAQKNLIGLVELIEINYIHRSAEFQIIIAPEHQGKGFARTLINRALDYSFTILNLHKIYLHVAVENPKAVHLYEECGFVEEGHLVEEFFINGRYQDVKRMYILQSKYLN