2mp2 A BS01 III C 1 N4 H6 N8 V19 Q20 F21 K22 I23 K24 R25 H26 T27 P28 K31 A35 R39 Q40 T59 N4 H6 N8 V19 Q20 F21 K22 I23 K24 R25 H26 T27 P28 K31 A35 R39 Q40 T59 P55854 GTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG 2mp2 B BS01 III C 1 E4 K5 N14 H16 N18 V28 V29 Q30 F31 K32 I33 K34 R35 H36 T37 K41 L42 E48 R49 E4 K5 N14 H16 N18 V28 V29 Q30 F31 K32 I33 K34 R35 H36 T37 K41 L42 E48 R49 P55854 GSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQT 3wq7 A 1.68 BS01 CA A 1 D68 D70 D72 N74 P75 E76 D142 D19 D21 D23 N25 P26 E27 D93 3.2.1.4 Q9V2T0 KVLKIRYPDDGEWPGAPIDKDGDGNPEFYIEINLWNILNATGFAEMTYNLTSGVLHYVQQLDNIVLRDRSNWVHGYPEIFYGNKPWNANYATDGPIPLPSKVSNLTDFYLTISYKLEPKNGLPINFAIESWLTREAWRTTGINSDEQEVMIWIYYDGLQPAGSKVKEIVVPIIVNGTPVNATFEVWKANIGWEYVAFRIKTPIKEGTVTIPYGAFISVAANISSLPNYTELYLEDVEIGTEFGTPSTTSAHLEWWITNITLTPLDRPLIS 3wq7 A 1.68 BS02 CA A 2 K168 N169 L171 S298 A299 H300 K119 N120 L122 S249 A250 H251 3.2.1.4 Q9V2T0 KVLKIRYPDDGEWPGAPIDKDGDGNPEFYIEINLWNILNATGFAEMTYNLTSGVLHYVQQLDNIVLRDRSNWVHGYPEIFYGNKPWNANYATDGPIPLPSKVSNLTDFYLTISYKLEPKNGLPINFAIESWLTREAWRTTGINSDEQEVMIWIYYDGLQPAGSKVKEIVVPIIVNGTPVNATFEVWKANIGWEYVAFRIKTPIKEGTVTIPYGAFISVAANISSLPNYTELYLEDVEIGTEFGTPSTTSAHLEWWITNITLTPLDRPLIS 3wq7 B 1.68 BS02 CA B 2 N169 L171 T296 S298 N120 L122 T247 S249 3.2.1.4 Q9V2T0 KVLKIRYPDDGEWPGAPIDKDGDGNPEFYIEINLWNILNATGFAEMTYNLTSGVLHYVQQLDNIVLRDRSNWVHGYPEIFYGNKPWNANYATDGPIPLPSKVSNLTDFYLTISYKLEPKNGLPINFAIESWLTREAWRTTGINSDEQEVMIWIYYDGLQPAGSKVKEIVVPIIVNGTPVNATFEVWKANIGWEYVAFRIKTPIKEGTVTIPYGAFISVAANISSLPNYTELYLEDVEIGTEFGTPSTTSAHLEWWITNITLTPLDRPLIS 3wtg A 2.30 BS01 HEM A 1 Y42 F43 F46 H58 K61 A65 L66 L83 L86 H87 L91 V93 N97 F98 L101 V132 L136 Y42 F43 F46 H58 K61 A65 L66 L83 L86 H87 L91 V93 N97 F98 L101 V132 L136 C6L8R0 VLSAADKTNTKSVFAKIGPHAEEYGAETLERLFTTYPQTKTYFPHFDLHHGSAQVKAHGKKVAAALVEAANHIDDISTALSKLSDLHAQKLRVDPVNFKLLGQCFLVVVAIHHPSLLTPEVHASLDKFLCAVANVLTA 3wtg A 2.30 BS02 OXY A 1 H58 V62 H58 V62 C6L8R0 VLSAADKTNTKSVFAKIGPHAEEYGAETLERLFTTYPQTKTYFPHFDLHHGSAQVKAHGKKVAAALVEAANHIDDISTALSKLSDLHAQKLRVDPVNFKLLGQCFLVVVAIHHPSLLTPEVHASLDKFLCAVANVLTA 3wtg B 2.30 BS01 HEM B 1 L31 T38 F41 F42 H63 K66 S70 F71 L88 L91 H92 L96 V98 N102 F103 L106 L141 L31 T38 F41 F42 H63 K66 S70 F71 L88 L91 H92 L96 V98 N102 F103 L106 L141 VQWSAEEKQLISSLWGKVNVAECGAEALARLLIVYPWTQRFFTSFGNLSSASAIIGNPMVRAHGKKVLTSFGDAVKNLDNIKNTFAQLSELHCDKLHVDPENFRLLGDILIIVLAAHFAKEFTPECQAAWQKLVRVVAHALARKYH 3wtg C 2.30 BS01 HEM C 1 Y42 F43 H45 F46 H58 K61 A65 L83 L86 H87 L91 V93 N97 F98 L101 L136 Y42 F43 H45 F46 H58 K61 A65 L83 L86 H87 L91 V93 N97 F98 L101 L136 C6L8R0 VLSAADKTNTKSVFAKIGPHAEEYGAETLERLFTTYPQTKTYFPHFDLHHGSAQVKAHGKKVAAALVEAANHIDDISTALSKLSDLHAQKLRVDPVNFKLLGQCFLVVVAIHHPSLLTPEVHASLDKFLCAVANVLTA 3wtg C 2.30 BS02 OXY C 1 F43 H58 V62 F43 H58 V62 C6L8R0 VLSAADKTNTKSVFAKIGPHAEEYGAETLERLFTTYPQTKTYFPHFDLHHGSAQVKAHGKKVAAALVEAANHIDDISTALSKLSDLHAQKLRVDPVNFKLLGQCFLVVVAIHHPSLLTPEVHASLDKFLCAVANVLTA 4c4a A 1.70 BS01 SAH A 1 Y35 M38 R44 I71 G72 T73 G74 L78 E94 V95 K121 H122 S123 E144 L145 S158 Y9 M12 R18 I45 G46 T47 G48 L52 E68 V69 K95 H96 S97 E118 L119 S132 2.1.1.-,2.1.1.125,2.1.1.126 Q922X9 HQEIARSSYADMLHDKDRNIKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINKHSTEVTVGPDGDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVESRRMWSWNKLFPVRVRTSLGEQVIVPPSELERCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSVDFSKQVSSSAACHSRQFVPLASGQAQVVLSWWDIEMDPEGKIKCTMAPFWAQTDPQELQWRDHWMQCVYFLPQEEPVVQGSPRCLVAHHDDYCVWYSLQRTSPQVRPVCDCQAHLLWNRPRFGEINDQDRTDHYAQALRTVLLPGSVCLCVSDGSLLSMLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLEDKISVINKRPELLTAADLEGKKVSLLLGEPFFTTSLLPWHNLYFWYVRTSVDQHLAPGAVVMPQAASLHAVIVEFRDLWRIRSPCGDCEGFDVHIMDDMIKHSLDFRESREAEPHPLWEYPCRSLSKPQEILTFDFQQPIPQQPMQSKGTMELTRPGKSHGAVLWMEYQLTPDSTISTGLINPGDCCWNPHCKQAVYFLSTPRSVSYVVEFHPLTGDITMEFRLA 4c4a A 1.70 BS02 DMX A 1 R458 L491 Y492 Y495 I589 P676 L677 T678 G679 R425 L458 Y459 Y462 I556 P629 L630 T631 G632 2.1.1.-,2.1.1.125,2.1.1.126 Q922X9 HQEIARSSYADMLHDKDRNIKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINKHSTEVTVGPDGDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVESRRMWSWNKLFPVRVRTSLGEQVIVPPSELERCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSVDFSKQVSSSAACHSRQFVPLASGQAQVVLSWWDIEMDPEGKIKCTMAPFWAQTDPQELQWRDHWMQCVYFLPQEEPVVQGSPRCLVAHHDDYCVWYSLQRTSPQVRPVCDCQAHLLWNRPRFGEINDQDRTDHYAQALRTVLLPGSVCLCVSDGSLLSMLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLEDKISVINKRPELLTAADLEGKKVSLLLGEPFFTTSLLPWHNLYFWYVRTSVDQHLAPGAVVMPQAASLHAVIVEFRDLWRIRSPCGDCEGFDVHIMDDMIKHSLDFRESREAEPHPLWEYPCRSLSKPQEILTFDFQQPIPQQPMQSKGTMELTRPGKSHGAVLWMEYQLTPDSTISTGLINPGDCCWNPHCKQAVYFLSTPRSVSYVVEFHPLTGDITMEFRLA 4c4a A 1.70 BS03 ZN A 1 C219 C366 C368 H371 C193 C333 C335 H338 2.1.1.-,2.1.1.125,2.1.1.126 Q922X9 HQEIARSSYADMLHDKDRNIKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINKHSTEVTVGPDGDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVESRRMWSWNKLFPVRVRTSLGEQVIVPPSELERCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSVDFSKQVSSSAACHSRQFVPLASGQAQVVLSWWDIEMDPEGKIKCTMAPFWAQTDPQELQWRDHWMQCVYFLPQEEPVVQGSPRCLVAHHDDYCVWYSLQRTSPQVRPVCDCQAHLLWNRPRFGEINDQDRTDHYAQALRTVLLPGSVCLCVSDGSLLSMLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLEDKISVINKRPELLTAADLEGKKVSLLLGEPFFTTSLLPWHNLYFWYVRTSVDQHLAPGAVVMPQAASLHAVIVEFRDLWRIRSPCGDCEGFDVHIMDDMIKHSLDFRESREAEPHPLWEYPCRSLSKPQEILTFDFQQPIPQQPMQSKGTMELTRPGKSHGAVLWMEYQLTPDSTISTGLINPGDCCWNPHCKQAVYFLSTPRSVSYVVEFHPLTGDITMEFRLA 4c5y A 3.00 BS01 ZN A 1 H111 H113 K246 D378 H67 H69 K202 D334 3.4.13.9,3.5.1.- A2R2V4 24947135 DEAKVTIIYAGLLIPGDGEPLRNAALVISDKIIAFVGSEADIPKKYLRSTQSTHRVPVLMPGLWDCHMHFGGDDDYYNDYTSGLATHPASSGARLARGCWEALQNGYTSYRDLAGYGCEVAKAINDGTIVGPNVYSSGAALSQTAGHGDIFALPAGEVLGSYGVMNPRPGYWGAGPLCIADGVEEVRRAVRLQIRRGAKVIKVMASGGVMSRDDNPNFAQFSPEELKVIVEEAARQNRIVSAHVHGKAGIMAAIKAGCKSLEHVSYADEEVWELMKEKGILYVATRSVIEIFLASNGEGLVKESWAKLQALADSHLKAYQGAIKAGVTIALGTDTAPGGPTALELQFAVERGGMTPLEAIKAATANAPLSVGPQAPLTGQLREGYEADVIALEENPLEDIKVFQEPKAVTHVWKGGKLFKGPGIGPWGEDARNPFL 4c5y A 3.00 BS02 ZN A 2 H111 K246 H287 H307 H67 K202 H243 H263 3.4.13.9,3.5.1.- A2R2V4 24947135 DEAKVTIIYAGLLIPGDGEPLRNAALVISDKIIAFVGSEADIPKKYLRSTQSTHRVPVLMPGLWDCHMHFGGDDDYYNDYTSGLATHPASSGARLARGCWEALQNGYTSYRDLAGYGCEVAKAINDGTIVGPNVYSSGAALSQTAGHGDIFALPAGEVLGSYGVMNPRPGYWGAGPLCIADGVEEVRRAVRLQIRRGAKVIKVMASGGVMSRDDNPNFAQFSPEELKVIVEEAARQNRIVSAHVHGKAGIMAAIKAGCKSLEHVSYADEEVWELMKEKGILYVATRSVIEIFLASNGEGLVKESWAKLQALADSHLKAYQGAIKAGVTIALGTDTAPGGPTALELQFAVERGGMTPLEAIKAATANAPLSVGPQAPLTGQLREGYEADVIALEENPLEDIKVFQEPKAVTHVWKGGKLFKGPGIGPWGEDARNPFL 4c5y B 3.00 BS01 ZN B 1 H111 H113 K246 H67 H69 K202 3.4.13.9,3.5.1.- A2R2V4 24947135 DEAKVTIIYAGLLIPGDGEPLRNAALVISDKIIAFVGSEADIPKKYLRSTQSTHRVPVLMPGLWDCHMHFGGDDDYYNDYTSGLATHPASSGARLARGCWEALQNGYTSYRDLAGYGCEVAKAINDGTIVGPNVYSSGAALSQTAGHGDIFALPAGEVLGSYGVMNPRPGYWGAGPLCIADGVEEVRRAVRLQIRRGAKVIKVMASGGVMSRDDNPNFAQFSPEELKVIVEEAARQNRIVSAHVHGKAGIMAAIKAGCKSLEHVSYADEEVWELMKEKGILYVATRSVIEIFLASNGEGLVKESLQALADSHLKAYQGAIKAGVTIALGTDTAPGGPTALELQFAVERGGMTPLEAIKAATANAPLSVGPQAPLTGQLREGYEADVIALEENPLEDIKVFQEPKAVTHVWKGGKLFKGPGIGPWGEDARNPFL 4cne A 1.90 BS01 SAH A 1 T79 S80 A81 F113 G114 R115 R117 G119 V132 I134 S141 S142 L143 L145 A148 T84 S85 A86 F118 G119 R120 R122 G124 V137 I139 S146 S147 L148 L150 A153 2.1.1.200 P0AE01 24951554 DPALRALQNIRIVLVETSHTGNMGSVARAMKTMGLTNLWLVNPLVKPDSQAIALAAGASDVIGNAHIVDTLDEALAGCSLVVGTSARSRTLPWPMLDPRECGLKSVAEAANTPVALVFGRERVGLTNEELQKCHYHVAIAANPEYSSLNLAMAVQVIAYEVRMAWLATQ 4cnf A 1.40 BS01 MTA A 1 T77 S78 S79 F110 G111 R112 G116 L129 I131 P138 V139 L140 A145 T77 S78 S79 F108 G109 R110 G114 L127 I129 P136 V137 L138 A143 2.1.1.200 Q4JB16 24951554 MTIRLVIVEPEGAYNLGFIARLVKNFLIDEFYVVNPKADINEAIKFSAKGSEVIEKMMKITNNFDDAIRDVDLKIATSSIADGDLLRKSIRPIDLERLIKDKKVAFIFGRESVGLTREEIAKSDFLLFIPANPEYPVLNLSHAVGIVLYELWRNR 4cng A 1.10 BS01 SAH A 1 T77 S78 S79 F110 G111 R112 S114 V115 G116 L129 F130 I131 P138 V139 L140 A145 T77 S78 S79 F110 G111 R112 S114 V115 G116 L129 F130 I131 P138 V139 L140 A145 2.1.1.200 Q4JB16 24951554 MTIRLVIVEPEGAYNLGFIARLVKNFLIDEFYVVNPKADINEAIKFSAKGSEVIEKMMKITNNFDDAIRDVDLKIATSSIADIKGDLLRKSIRPIDLERLIKDKKVAFIFGRESVGLTREEIAKSDFLLFIPANPEYPVLNLSHAVGIVLYELWRN 4cng A 1.10 BS02 SAH A 2 S78 I80 D82 I83 K84 L87 V115 G116 L117 R119 S78 I80 D82 I83 K84 L87 V115 G116 L117 R119 2.1.1.200 Q4JB16 24951554 MTIRLVIVEPEGAYNLGFIARLVKNFLIDEFYVVNPKADINEAIKFSAKGSEVIEKMMKITNNFDDAIRDVDLKIATSSIADIKGDLLRKSIRPIDLERLIKDKKVAFIFGRESVGLTREEIAKSDFLLFIPANPEYPVLNLSHAVGIVLYELWRN 4cng B 1.10 BS01 SAH B 1 T77 S78 S79 D82 F110 G111 R112 E113 S114 V115 G116 I131 P138 V139 L140 A145 T77 S78 S79 D82 F102 G103 R104 E105 S106 V107 G108 I123 P130 V131 L132 A137 2.1.1.200 Q4JB16 24951554 MTIRLVIVEPEGAYNLGFIARLVKNFLIDEFYVVNPKADINEAIKFSAKGSEVIEKMMKITNNFDDAIRDVDLKIATSSIADSIRPIDLERLIKDKKVAFIFGRESVGLTREEIAKSDFLLFIPANPEYPVLNLSHAVGIVLYELWRN 4cqn A 2.50 BS01 NUC B 1 Y43 D80 G83 L84 V156 A167 N168 E169 Q190 T215 T218 M219 N222 W223 A291 E292 A293 A296 R416 L417 R418 S423 R424 Q425 R426 F493 E532 M536 M568 L570 M617 S618 K619 F648 A649 S650 P651 M654 Q659 G662 G665 R668 K711 R718 R719 N723 T724 A727 M730 N734 V803 Q805 K809 V810 R811 K813 K837 Y838 I848 V850 L854 N856 V858 Y43 D80 G83 L84 V156 A167 N168 E169 Q190 T215 T218 M219 N222 W223 A291 E292 A293 A296 R416 L417 R418 S423 R424 Q425 R426 F493 E532 M536 M568 L570 M617 S618 K619 F648 A649 S650 P651 M654 Q659 G662 G665 R668 K711 R718 R719 N723 T724 A727 M730 N734 V803 Q805 K809 V810 R811 K813 K837 Y838 I848 V850 L854 N856 V858 6.1.1.4 P07813 24935946 MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG 4cqn A 2.50 BS02 ZN A 1 C159 D162 C176 C179 T181 C159 D162 C176 C179 T181 6.1.1.4 P07813 24935946 MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG 4cqn A 2.50 BS03 ILA A 1 M40 L41 P42 Y43 H49 G51 H52 N55 Y56 D80 S496 G529 G530 E532 H533 H537 Q566 G567 M568 V569 K619 M620 M40 L41 P42 Y43 H49 G51 H52 N55 Y56 D80 S496 G529 G530 E532 H533 H537 Q566 G567 M568 V569 K619 M620 6.1.1.4 P07813 24935946 MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG 4cqn A 2.50 BS04 ILA A 2 T247 T248 R249 T252 F325 V335 M336 H341 D342 R344 D345 T247 T248 R249 T252 F325 V335 M336 H341 D342 R344 D345 6.1.1.4 P07813 24935946 MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG 4cqn D 2.50 BS01 NUC E 1 Y43 D80 G83 L84 V156 N157 A167 N168 E169 Q190 T215 T218 M219 N222 W223 A291 E292 A293 A296 T297 R416 R418 S423 R424 R426 T492 F493 E532 I535 M536 M568 L570 M617 S618 K619 F648 A649 S650 P651 M654 Q659 S661 G662 G665 R668 K671 K711 D714 R719 N723 T724 A727 M730 E731 N734 L801 V803 Q805 V810 R811 K813 K846 I848 V850 K853 L854 N856 Y43 D80 G83 L84 V156 N157 A167 N168 E169 Q190 T215 T218 M219 N222 W223 A291 E292 A293 A296 T297 R416 R418 S423 R424 R426 T492 F493 E532 I535 M536 M568 L570 M617 S618 K619 F648 A649 S650 P651 M654 Q659 S661 G662 G665 R668 K671 K711 D714 R719 N723 T724 A727 M730 E731 N734 L801 V803 Q805 V810 R811 K813 K846 I848 V850 K853 L854 N856 6.1.1.4 P07813 24935946 MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG 4cqn D 2.50 BS03 ILA D 1 M40 L41 P42 Y43 H49 G51 H52 N55 Y56 D80 S496 G529 G530 E532 H533 Q566 M568 V569 M620 M40 L41 P42 Y43 H49 G51 H52 N55 Y56 D80 S496 G529 G530 E532 H533 Q566 M568 V569 M620 6.1.1.4 P07813 24935946 MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG 4cqn D 2.50 BS04 ILA D 2 T247 T248 Y330 V335 M336 V338 D342 R344 D345 T247 T248 Y330 V335 M336 V338 D342 R344 D345 6.1.1.4 P07813 24935946 MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG 4d1a A 3.40 BS01 I5H A 1 Q42 A44 I45 W117 Q121 G219 W220 A222 N318 Q32 A34 I35 W107 Q111 G209 W210 A212 N308 D6R8X8 24952894 SLLNPSNAPTRYAERSVGPFSLAAIWFAMAIQVAIFIAAGQMTSSFQVWQVIVAIAAGCTIAVILLFFTQSAAIRWGINFTVAARMPFGIRGSLIPITLKALLSLFWFGFQTWLGALALDEITRLLTGFTNLPLWIVIFGAIQVVTTFYGITFIRWMNVFASPVLLAMGVYMVYLMLDGADVSLGEVMSMGGENPGMPFSTAIMIFVGGWIAVVVSIHDIVKECKVDPNASREGQTKADARYATAQWLGMVPASIIFGFIGAASMVLVGEWNPVIAITEVVGGVSIPMAILFQVFVLLATWSTNPAANLLSPAYTLCSTFPRVFTFKTGVIVSAVVGLLMMPWQFAGVLNTFLNLLASALGPLAGIMISDYFLVRRRRISLHDLYRTKGIYTYWRGVNWVALAVYAVALAVSFLTPDLMFVTGLIAALLLHIPAMRWVAKTFPLFSEAESRNEDYL 4d1a A 3.40 BS02 NA A 1 A38 M39 I41 Q42 A309 T310 S312 T313 A28 M29 I31 Q32 A299 T300 S302 T303 D6R8X8 24952894 SLLNPSNAPTRYAERSVGPFSLAAIWFAMAIQVAIFIAAGQMTSSFQVWQVIVAIAAGCTIAVILLFFTQSAAIRWGINFTVAARMPFGIRGSLIPITLKALLSLFWFGFQTWLGALALDEITRLLTGFTNLPLWIVIFGAIQVVTTFYGITFIRWMNVFASPVLLAMGVYMVYLMLDGADVSLGEVMSMGGENPGMPFSTAIMIFVGGWIAVVVSIHDIVKECKVDPNASREGQTKADARYATAQWLGMVPASIIFGFIGAASMVLVGEWNPVIAITEVVGGVSIPMAILFQVFVLLATWSTNPAANLLSPAYTLCSTFPRVFTFKTGVIVSAVVGLLMMPWQFAGVLNTFLNLLASALGPLAGIMISDYFLVRRRRISLHDLYRTKGIYTYWRGVNWVALAVYAVALAVSFLTPDLMFVTGLIAALLLHIPAMRWVAKTFPLFSEAESRNEDYL 4d1b A 3.80 BS01 5FH A 1 Q42 A44 W117 Q121 G219 W220 A222 V223 N318 Q32 A34 W107 Q111 G209 W210 A212 V213 N308 D6R8X8 24952894 SLLNPSNAPTRYAERSVGPFSLAAIWFAMAIQVAIFIAAGQMTSSFQVWQVIVAIAAGCTIAVILLFFTQSAAIRWGINFTVAARMPFGIRGSLIPITLKALLSLFWFGFQTWLGALALDEITRLLTGFTNLPLWIVIFGAIQVVTTFYGITFIRWMNVFASPVLLAMGVYMVYLMLDGADVSLGEVMSMGGENPGMPFSTAIMIFVGGWIAVVVSIHDIVKECKVDPNASREGQTKADARYATAQWLGMVPASIIFGFIGAASMVLVGEWNPVIAITEVVGGVSIPMAILFQVFVLLATWSTNPAANLLSPAYTLCSTFPRVFTFKTGVIVSAVVGLLMMPWQFAGVLNTFLNLLASALGPLAGIMISDYFLVRRRRISLHDLYRTKGIYTYWRGVNWVALAVYAVALAVSFLTPDLMFVTGLIAALLLHIPAMRWVAKTFPLFSEAESRNEDYL 4d1b A 3.80 BS02 NA A 1 A38 M39 I41 Q42 A309 S312 T313 A28 M29 I31 Q32 A299 S302 T303 D6R8X8 24952894 SLLNPSNAPTRYAERSVGPFSLAAIWFAMAIQVAIFIAAGQMTSSFQVWQVIVAIAAGCTIAVILLFFTQSAAIRWGINFTVAARMPFGIRGSLIPITLKALLSLFWFGFQTWLGALALDEITRLLTGFTNLPLWIVIFGAIQVVTTFYGITFIRWMNVFASPVLLAMGVYMVYLMLDGADVSLGEVMSMGGENPGMPFSTAIMIFVGGWIAVVVSIHDIVKECKVDPNASREGQTKADARYATAQWLGMVPASIIFGFIGAASMVLVGEWNPVIAITEVVGGVSIPMAILFQVFVLLATWSTNPAANLLSPAYTLCSTFPRVFTFKTGVIVSAVVGLLMMPWQFAGVLNTFLNLLASALGPLAGIMISDYFLVRRRRISLHDLYRTKGIYTYWRGVNWVALAVYAVALAVSFLTPDLMFVTGLIAALLLHIPAMRWVAKTFPLFSEAESRNEDYL 4d1c A 3.70 BS01 B5H A 1 Q42 A44 I45 A48 W117 Q121 G219 W220 A222 V223 N318 L363 Q32 A34 I35 A38 W107 Q111 G209 W210 A212 V213 N308 L353 D6R8X8 24952894 SLLNPSNAPTRYAERSVGPFSLAAIWFAMAIQVAIFIAAGQMTSSFQVWQVIVAIAAGCTIAVILLFFTQSAAIRWGINFTVAARMPFGIRGSLIPITLKALLSLFWFGFQTWLGALALDEITRLLTGFTNLPLWIVIFGAIQVVTTFYGITFIRWMNVFASPVLLAMGVYMVYLMLDGADVSLGEVMSMGGENPGMPFSTAIMIFVGGWIAVVVSIHDIVKECKVDPNASREGQTKADARYATAQWLGMVPASIIFGFIGAASMVLVGEWNPVIAITEVVGGVSIPMAILFQVFVLLATWSTNPAANLLSPAYTLCSTFPRVFTFKTGVIVSAVVGLLMMPWQFAGVLNTFLNLLASALGPLAGIMISDYFLVRRRRISLHDLYRTKGIYTYWRGVNWVALAVYAVALAVSFLTPDLMFVTGLIAALLLHIPAMRWVAKTFPLFSEAESRNEDYL 4d1d A 3.70 BS01 5NL A 1 Q42 A44 A48 W117 Q121 F216 G219 W220 A222 V223 N318 Q32 A34 A38 W107 Q111 F206 G209 W210 A212 V213 N308 D6R8X8 24952894 SLLNPSNAPTRYAERSVGPFSLAAIWFAMAIQVAIFIAAGQMTSSFQVWQVIVAIAAGCTIAVILLFFTQSAAIRWGINFTVAARMPFGIRGSLIPITLKALLSLFWFGFQTWLGALALDEITRLLTGFTNLPLWIVIFGAIQVVTTFYGITFIRWMNVFASPVLLAMGVYMVYLMLDGADVSLGEVMSMGGENPGMPFSTAIMIFVGGWIAVVVSIHDIVKECKVDPNASREGQTKADARYATAQWLGMVPASIIFGFIGAASMVLVGEWNPVIAITEVVGGVSIPMAILFQVFVLLATWSTNPAANLLSPAYTLCSTFPRVFTFKTGVIVSAVVGLLMMPWQFAGVLNTFLNLLASALGPLAGIMISDYFLVRRRRISLHDLYRTKGIYTYWRGVNWVALAVYAVALAVSFLTPDLMFVTGLIAALLLHIPAMRWVAKTFPLFSEAESRNEDYL 4d1d A 3.70 BS02 5ND A 1 Q42 A48 W117 Q121 I215 F216 G219 W220 A222 N318 Q32 A38 W107 Q111 I205 F206 G209 W210 A212 N308 D6R8X8 24952894 SLLNPSNAPTRYAERSVGPFSLAAIWFAMAIQVAIFIAAGQMTSSFQVWQVIVAIAAGCTIAVILLFFTQSAAIRWGINFTVAARMPFGIRGSLIPITLKALLSLFWFGFQTWLGALALDEITRLLTGFTNLPLWIVIFGAIQVVTTFYGITFIRWMNVFASPVLLAMGVYMVYLMLDGADVSLGEVMSMGGENPGMPFSTAIMIFVGGWIAVVVSIHDIVKECKVDPNASREGQTKADARYATAQWLGMVPASIIFGFIGAASMVLVGEWNPVIAITEVVGGVSIPMAILFQVFVLLATWSTNPAANLLSPAYTLCSTFPRVFTFKTGVIVSAVVGLLMMPWQFAGVLNTFLNLLASALGPLAGIMISDYFLVRRRRISLHDLYRTKGIYTYWRGVNWVALAVYAVALAVSFLTPDLMFVTGLIAALLLHIPAMRWVAKTFPLFSEAESRNEDYL 4d1d A 3.70 BS03 NA A 1 A38 M39 I41 A309 T310 S312 T313 A28 M29 I31 A299 T300 S302 T303 D6R8X8 24952894 SLLNPSNAPTRYAERSVGPFSLAAIWFAMAIQVAIFIAAGQMTSSFQVWQVIVAIAAGCTIAVILLFFTQSAAIRWGINFTVAARMPFGIRGSLIPITLKALLSLFWFGFQTWLGALALDEITRLLTGFTNLPLWIVIFGAIQVVTTFYGITFIRWMNVFASPVLLAMGVYMVYLMLDGADVSLGEVMSMGGENPGMPFSTAIMIFVGGWIAVVVSIHDIVKECKVDPNASREGQTKADARYATAQWLGMVPASIIFGFIGAASMVLVGEWNPVIAITEVVGGVSIPMAILFQVFVLLATWSTNPAANLLSPAYTLCSTFPRVFTFKTGVIVSAVVGLLMMPWQFAGVLNTFLNLLASALGPLAGIMISDYFLVRRRRISLHDLYRTKGIYTYWRGVNWVALAVYAVALAVSFLTPDLMFVTGLIAALLLHIPAMRWVAKTFPLFSEAESRNEDYL 4ike A 1.48 BS01 AMP A 1 T31 L35 R36 M53 E57 L58 V59 I64 G82 R85 Q89 R150 T31 L35 R36 M53 E57 L58 V59 I64 G82 R85 Q89 R150 2.7.4.3 O66490 MILVFLGPPGAGKGTQAKRLAKEKGFVHISTGDILREAVQKGTPLGKKAKEYMERGELVPDDLIIALIEEVFPKHGNVIFDGFPRTVKQAEALDEMLEKKGLKVDHVLLFEVPDEVVIERLSGRRINPETGEVYHVKYNPPPPGVKVIQREDDKPEVIKKRLEVYREQTAPLIEYYKKKGILRIIDASKPVEEVYRQVLEVIGDGN 4ike B 1.48 BS01 AMP B 1 T31 G32 L35 R36 M53 E57 L58 V59 I64 G82 R85 Q89 T31 G32 L35 R36 M53 E57 L58 V59 I64 G82 R85 Q89 2.7.4.3 O66490 MILVFLGPPGAGKGTQAKRLAKEKGFVHISTGDILREAVQKGTPLGKKAKEYMERGELVPDDLIIALIEEVFPKHGNVIFDGFPRTVKQAEALDEMLEKKGLKVDHVLLFEVPDEVVIERLSGRRINPETGEVYHVKYNPPPPGVKVIQREDDKPEVIKKRLEVYREQTAPLIEYYKKKGILRIIDASKPVEEVYRQVLEVIGDGN 4ike B 1.48 BS02 ADP B 1 G10 A11 G12 K13 G14 T15 R120 R124 K189 P190 V191 G10 A11 G12 K13 G14 T15 R120 R124 K189 P190 V191 2.7.4.3 O66490 MILVFLGPPGAGKGTQAKRLAKEKGFVHISTGDILREAVQKGTPLGKKAKEYMERGELVPDDLIIALIEEVFPKHGNVIFDGFPRTVKQAEALDEMLEKKGLKVDHVLLFEVPDEVVIERLSGRRINPETGEVYHVKYNPPPPGVKVIQREDDKPEVIKKRLEVYREQTAPLIEYYKKKGILRIIDASKPVEEVYRQVLEVIGDGN 4lf4 B 3.34 BS01 NUC A 1 K22 W24 P26 R96 G99 G100 T103 N104 T107 I108 R111 Y148 I172 R175 E176 K179 K17 W19 P21 R91 G94 G95 T98 N99 T102 I103 R106 Y143 I167 R170 E171 K174 P80371 TVKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ 4lf4 B 3.34 BS02 MG B 1 H19 K74 D166 D191 D205 D206 H14 K69 D161 D186 D200 D201 P80371 TVKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ 4lf4 C 3.34 BS01 NUC A 1 G2 N3 K4 I5 F10 K26 K27 R127 S154 G155 R156 E161 Q162 A163 W167 R172 V173 P174 L175 H176 T177 L178 R179 F186 R190 T192 Y193 G194 V195 G197 K199 G1 N2 K3 I4 F9 K25 K26 R126 S153 G154 R155 E160 Q161 A162 W166 R171 V172 P173 L174 H175 T176 L177 R178 F185 R189 T191 Y192 G193 V194 G196 K198 P80372 GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAGLARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVALNVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKVIVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAYIFLGEV 4lf4 D 3.34 BS01 NUC A 1 G2 R3 Y4 I5 P7 V8 C9 R10 R13 R14 L21 K22 E24 R25 K30 A32 R35 R36 Y38 P40 G41 Q42 H43 Q45 K46 S52 Y54 A55 R59 K61 Q62 R65 R66 E72 R73 Q74 N77 V112 S113 R115 Q116 R118 Q119 R122 H123 H125 R132 V133 D134 L135 P136 S137 Y138 L155 E205 S208 R209 G1 R2 Y3 I4 P6 V7 C8 R9 R12 R13 L20 K21 E23 R24 K29 A31 R34 R35 Y37 P39 G40 Q41 H42 Q44 K45 S51 Y53 A54 R58 K60 Q61 R64 R65 E71 R72 Q73 N76 V111 S112 R114 Q115 R117 Q118 R121 H122 H124 R131 V132 D133 L134 P135 S136 Y137 L154 E204 S207 R208 P80373 GRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRPSDYAVRLREKQKLRRIYGISERQFRNLFEEASKKKGVTGSVFLGLLESRLDNVVYRLGFAVSRRQARQLVRHGHITVNGRRVDLPSYRVRPGDEIAVAEKSRNLELIRQNLEAMKGRKVGPWLSLDVEGMKGKFLRLPDREDLALPVNEQLVIEFYSR 4lf4 E 3.34 BS01 NUC A 1 R14 T16 A17 R18 M19 Q20 A21 G22 R24 R25 F45 K47 P49 K57 Y61 A86 K92 A94 A95 T98 I101 A102 L119 T120 K121 E122 L123 S125 R126 N127 N130 Y133 R10 T12 A13 R14 M15 Q16 A17 G18 R20 R21 F41 K43 P45 K53 Y57 A82 K88 A90 A91 T94 I97 A98 L115 T116 K117 E118 L119 S121 R122 N123 N126 Y129 Q5SHQ5 DFEEKMILIRRTARMQAGGRRFRFGALVVVGDRQGRVGLGFGKAPEVPLAVQKAGYYARRNMVEVPLQNGTIPHEIEVEFGASKIVLKPAAPGTGVIAGAVPRAILELAGVTDILTKELGSRNPINIAYATMEALRQLRTKADVERLRKG 4lf4 G 3.34 BS01 NUC A 1 A2 R3 R4 R5 R6 A7 R10 L12 N28 K29 I30 M31 R32 D33 G34 K35 K36 N37 L38 R41 I42 R79 G81 G82 R94 R95 S98 R102 N109 R114 R115 A116 R119 A1 R2 R3 R4 R5 A6 R9 L11 N27 K28 I29 M30 R31 D32 G33 K34 K35 N36 L37 R40 I41 R78 G80 G81 R93 R94 S97 R101 N108 R113 R114 A115 R118 P17291 ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQEKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLALRWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAYAHYRW 4lf4 H 3.34 BS01 NUC A 1 M1 L2 T3 A7 D8 T11 R12 R14 N15 V19 K21 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 V95 G96 V97 K98 S113 T114 S115 G128 V129 G130 G131 E132 M1 L2 T3 A7 D8 T11 R12 R14 N15 V19 K21 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 V95 G96 V97 K98 S113 T114 S115 G128 V129 G130 G131 E132 Q5SHQ2 MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYERVDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEIPRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW 4lf4 I 3.34 BS01 NUC A 1 Q3 Y5 T7 R9 R10 K11 E12 V14 R16 F18 R20 Y36 Q38 L40 Y62 R66 G67 G68 G69 K70 S71 G72 Q73 R83 R93 K97 L102 T103 R104 A106 R107 V108 V109 E110 R111 K112 K113 Y114 G115 H117 K118 R120 R121 A122 Q124 Y125 S126 K127 R128 Q2 Y4 T6 R8 R9 K10 E11 V13 R15 F17 R19 Y35 Q37 L39 Y61 R65 G66 G67 G68 K69 S70 G71 Q72 R82 R92 K96 L101 T102 R103 A105 R106 V107 V108 E109 R110 K111 K112 Y113 G114 H116 K117 R119 R120 A121 Q123 Y124 S125 K126 R127 P80374 EQYYGTGRRKEAVARVFLRPGNGKVTVNGQDFNEYFQGLVRAVAALEPLRAVDALGHFDAYITVRGGGKSGQIDAIKLGIARALVQYNPDYRAKLKPLGFLTRDARVVERKKYGKHKARRAPQYSKR 4lf4 J 3.34 BS01 NUC A 1 R5 K7 H13 D17 V34 S35 P37 I38 P39 L40 P41 T42 R43 V44 R45 R46 T48 I50 R51 G52 P53 F54 K55 H56 K57 R60 H62 H68 D73 E97 R3 K5 H11 D15 V32 S33 P35 I36 P37 L38 P39 T40 R41 V42 R43 R44 T46 I48 R49 G50 P51 F52 K53 H54 K55 R58 H60 H66 D71 E95 Q5SHN7 KIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRGPFKHKDSREHFELRTHNRLVDIINPNRKTIEQLMTLDLPTGVEIEIKT 4lf4 K 3.34 BS01 NUC A 1 Y20 N26 N27 I29 T31 G37 N38 P39 I40 W42 S44 G46 G52 S53 K55 R85 P113 V114 P115 H116 N117 G118 C119 R120 P121 K122 K123 K124 Y10 N16 N17 I19 T21 G27 N28 P29 I30 W32 S34 G36 G42 S43 K45 R75 P103 V104 P105 H106 N107 G108 C109 R110 P111 K112 K113 K114 P80376 KRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS 4lf4 L 3.34 BS01 NUC A 1 P5 T6 N8 Q9 R12 K13 R15 E16 K17 V18 R19 K20 K21 S22 K23 V24 K28 P31 F32 R33 R34 K46 K47 N49 S50 A51 L52 R53 K54 T61 Y69 P71 G72 E73 L84 R86 G87 R89 V90 K91 D92 R97 V101 V104 R113 K114 K115 S116 R117 S118 K119 Y120 G121 T122 K123 K124 P1 T2 N4 Q5 R8 K9 R11 E12 K13 V14 R15 K16 K17 S18 K19 V20 K24 P27 F28 R29 R30 K42 K43 N45 S46 A47 L48 R49 K50 T57 Y65 P67 G68 E69 L80 R82 G83 R85 V86 K87 D88 R93 V97 V100 R109 K110 K111 S112 R113 S114 K115 Y116 G117 T118 K119 K120 F6DEQ7 PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEA 4lf4 L 3.34 BS02 MG L 1 G63 Y64 E65 G59 Y60 E61 F6DEQ7 PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEA 4lf4 M 3.34 BS01 NUC A 1 K13 R14 V17 Y21 I22 Y23 G24 I25 G26 K27 A28 R29 R44 N77 I78 Y87 R88 R91 H92 L96 P97 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 R110 K111 R114 K115 T116 V117 K12 R13 V16 Y20 I21 Y22 G23 I24 G25 K26 A27 R28 R43 N76 I77 Y86 R87 R90 H91 L95 P96 V97 R98 Q100 R101 T102 R103 T104 N105 A106 R107 T108 R109 K110 R113 K114 T115 V116 P80377 ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQRTRTNARTRKGPRKTVAG 4lf4 N 3.34 BS01 NUC A 1 A2 R3 K4 A5 L6 K15 F16 V18 R19 Y21 T22 R23 C27 R29 R31 S32 V33 Y34 R35 R41 I42 C43 R45 E46 R57 K58 S60 W61 A1 R2 K3 A4 L5 K14 F15 V17 R18 Y20 T21 R22 C26 R28 R30 S31 V32 Y33 R34 R40 I41 C42 R44 E45 R56 K57 S59 W60 Q5SHQ1 ARKALIEKAKRTPKFKVRAYTRCVRCGRARSVYRFFGLCRICLRELAHKGQLPGVRKASW 4lf4 O 3.34 BS01 NUC A 1 P2 K5 K8 I12 F18 D21 T22 G23 S24 Q28 R35 R38 L39 H42 H46 K48 D49 H50 H51 S52 R54 G55 L57 M58 G61 Q62 R64 R65 L66 R68 Y69 R72 P1 K4 K7 I11 F17 D20 T21 G22 S23 Q27 R34 R37 L38 H41 H45 K47 D48 H49 H50 S51 R53 G54 L56 M57 G60 Q61 R63 R64 L65 R67 Y68 R71 Q5SJ76 PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHHSHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG 4lf4 P 3.34 BS01 NUC A 1 M1 V2 K3 R5 L6 R8 F9 S11 K12 H13 N14 P15 H16 Y17 R18 D23 A24 R25 R26 K27 R28 G30 K31 I33 K35 Y38 P41 K43 T44 W59 S61 V62 G63 Q65 T67 D68 T69 R72 R75 F80 R81 Q82 E83 M1 V2 K3 R5 L6 R8 F9 S11 K12 H13 N14 P15 H16 Y17 R18 D23 A24 R25 R26 K27 R28 G30 K31 I33 K35 Y38 P41 K43 T44 W59 S61 V62 G63 Q65 T67 D68 T69 R72 R75 F80 R81 Q82 E83 Q5SJH3 MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLKVDVERARYWLSVGAQPTDTARRLLRQAGVFRQE 4lf4 Q 3.34 BS01 NUC A 1 P2 K3 K4 S12 K14 M15 Q16 K17 T18 R25 L31 Y32 K34 R38 S39 K40 K41 Y42 E61 S62 R63 P64 I65 S66 K67 R68 K69 R70 F71 R72 K87 I90 R91 N94 Y95 S97 L98 S99 K100 G103 K104 A105 P1 K2 K3 S11 K13 M14 Q15 K16 T17 R24 L30 Y31 K33 R37 S38 K39 K40 Y41 E60 S61 R62 P63 I64 S65 K66 R67 K68 R69 F70 R71 K86 I89 R90 N93 Y94 S96 L97 S98 K99 G102 K103 A104 Q5SHP7 PKKVLTGVVVSDKMQKTVTVLVERQFPHPLYGKVIKRSKKYLAHDPEEKYKLGDVVEIIESRPISKRKRFRVLRLVESGRMDLVEKYLIRRQNYESLSKRGGKA 4lf4 S 3.34 BS01 NUC A 1 P2 R3 S4 L5 K6 F10 H14 K18 W34 R36 R37 Y52 N53 G54 K55 K70 G72 E73 T77 R78 T79 Y80 R81 P1 R2 S3 L4 K5 F9 H13 K17 W33 R35 R36 Y51 N52 G53 K54 K69 G71 E72 T76 R77 T78 Y79 R80 Q5SHP2 PRSLKKGVFVDDHLLEKVLELNAKGEKRLIKTWSRRSTIVPEMVGHTIAVYNGKQHVPVYITENMVGHKLGEFAPTRTYR 4lf4 T 3.34 BS01 NUC A 1 L10 K14 R15 H16 R17 Q18 S19 K21 R22 R23 R25 N26 K27 K29 S31 K34 T35 L36 K38 K39 R57 E60 S61 D64 K65 K68 S70 K74 N75 A78 R79 R80 K81 S82 R83 M85 K87 R89 G101 G102 G103 L104 S105 L3 K7 R8 H9 R10 Q11 S12 K14 R15 R16 R18 N19 K20 K22 S24 K27 T28 L29 K31 K32 R50 E53 S54 D57 K58 K61 S63 K67 N68 A71 R72 R73 K74 S75 R76 M78 K80 R82 G94 G95 G96 L97 S98 P80380 RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMRKAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGGLSA 4lf5 B 3.75 BS01 NUC A 1 K22 W24 P26 R96 L98 G99 G100 T103 N104 T107 R111 K132 K133 R144 K147 Y148 I172 E176 K179 K17 W19 P21 R91 L93 G94 G95 T98 N99 T102 R106 K127 K128 R139 K142 Y143 I167 E171 K174 P80371 TVKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ 4lf5 B 3.75 BS02 MG B 1 H19 K74 D166 D191 H14 K69 D161 D186 P80371 TVKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ 4lf5 G 3.75 BS01 NUC A 1 A2 R3 R4 R5 R6 A7 R10 N28 K29 I30 R32 D33 G34 K35 K36 N37 L38 I42 G81 R94 R95 S98 R102 N109 R114 R115 A116 R119 A1 R2 R3 R4 R5 A6 R9 N27 K28 I29 R31 D32 G33 K34 K35 N36 L37 I41 G80 R93 R94 S97 R101 N108 R113 R114 A115 R118 P17291 ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQEKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLALRWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAYAHYRW 4lf5 H 3.75 BS01 NUC A 1 M1 L2 T3 D4 D8 T11 R12 R14 N15 V19 K21 S29 R30 F31 K56 R75 K88 P89 R91 R92 Y94 V95 G96 V97 S113 T114 S115 G128 G130 E132 M1 L2 T3 D4 D8 T11 R12 R14 N15 V19 K21 S29 R30 F31 K56 R75 K88 P89 R91 R92 Y94 V95 G96 V97 S113 T114 S115 G128 G130 E132 Q5SHQ2 MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYERVDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEIPRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW 4lf5 J 3.75 BS01 NUC A 1 K7 R9 H13 Q33 S35 P37 I38 P39 L40 P41 T42 R43 V44 R45 R46 T48 I50 R51 P53 F54 K55 H56 K57 R60 H62 H68 R70 D73 E97 K99 K5 R7 H11 Q31 S33 P35 I36 P37 L38 P39 T40 R41 V42 R43 R44 T46 I48 R49 P51 F52 K53 H54 K55 R58 H60 H66 R68 D71 E95 K97 Q5SHN7 KIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRGPFKHKDSREHFELRTHNRLVDIINPNRKTIEQLMTLDLPTGVEIEIKT 4lf5 L 3.75 BS01 NUC A 1 P5 T6 N8 Q9 L10 R12 K13 R15 E16 K17 R19 K21 S22 K23 V24 K28 A30 P31 F32 R33 R34 K46 N49 S50 A51 L52 R53 K54 K57 T61 Y69 P71 G72 E73 R86 G87 R89 V90 K91 D92 P94 G95 R97 V101 V104 R113 K114 K115 S116 R117 S118 K119 Y120 G121 T122 K123 K124 P1 T2 N4 Q5 L6 R8 K9 R11 E12 K13 R15 K17 S18 K19 V20 K24 A26 P27 F28 R29 R30 K42 N45 S46 A47 L48 R49 K50 K53 T57 Y65 P67 G68 E69 R82 G83 R85 V86 K87 D88 P90 G91 R93 V97 V100 R109 K110 K111 S112 R113 S114 K115 Y116 G117 T118 K119 K120 F6DEQ7 PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEA 4lf5 M 3.75 BS01 NUC A 1 R14 V17 Y21 Y23 G24 I25 G26 A28 R29 R44 V74 N77 I78 Y87 R88 R91 H92 L96 P97 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 R110 K111 R114 K115 T116 V117 R13 V16 Y20 Y22 G23 I24 G25 A27 R28 R43 V73 N76 I77 Y86 R87 R90 H91 L95 P96 V97 R98 Q100 R101 T102 R103 T104 N105 A106 R107 T108 R109 K110 R113 K114 T115 V116 P80377 ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQRTRTNARTRKGPRKTVAG 4lf5 N 3.75 BS01 NUC A 1 A2 R3 K4 A5 L6 E8 K15 F16 K17 V18 R19 Y21 T22 R23 C27 R29 A30 R31 S32 V33 R35 R41 I42 R45 E46 K58 S60 W61 A1 R2 K3 A4 L5 E7 K14 F15 K16 V17 R18 Y20 T21 R22 C26 R28 A29 R30 S31 V32 R34 R40 I41 R44 E45 K57 S59 W60 Q5SHQ1 ARKALIEKAKRTPKFKVRAYTRCVRCGRARSVYRFFGLCRICLRELAHKGQLPGVRKASW 4lf5 O 3.75 BS01 NUC A 1 P2 K8 Q9 F18 D21 T22 G23 S24 T25 Q28 L31 R35 R38 L39 H42 H46 K48 D49 H50 H51 S52 H53 R54 G55 L57 M58 G61 R64 R65 Y69 R72 P1 K7 Q8 F17 D20 T21 G22 S23 T24 Q27 L30 R34 R37 L38 H41 H45 K47 D48 H49 H50 S51 H52 R53 G54 L56 M57 G60 R63 R64 Y68 R71 Q5SJ76 PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHHSHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG 4lf5 P 3.75 BS01 NUC A 1 M1 V2 K3 R5 L6 R8 F9 S11 K12 H13 N14 H16 Y17 R18 D23 A24 R25 R26 K27 R28 D29 G30 K31 K35 Y38 P41 R42 K43 T44 Y58 W59 S61 V62 G63 Q65 T67 D68 T69 R72 R75 F80 R81 Q82 E83 M1 V2 K3 R5 L6 R8 F9 S11 K12 H13 N14 H16 Y17 R18 D23 A24 R25 R26 K27 R28 D29 G30 K31 K35 Y38 P41 R42 K43 T44 Y58 W59 S61 V62 G63 Q65 T67 D68 T69 R72 R75 F80 R81 Q82 E83 Q5SJH3 MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLKVDVERARYWLSVGAQPTDTARRLLRQAGVFRQE 4lf5 T 3.75 BS01 NUC A 1 L10 K14 R15 H16 R17 Q18 K21 R22 R23 N26 K27 K29 S31 T35 K38 K39 R57 E60 S61 D64 K65 K68 S70 K74 N75 A78 R79 R80 K81 S82 R83 M85 R89 G102 G103 L104 S105 A106 L3 K7 R8 H9 R10 Q11 K14 R15 R16 N19 K20 K22 S24 T28 K31 K32 R50 E53 S54 D57 K58 K61 S63 K67 N68 A71 R72 R73 K74 S75 R76 M78 R82 G95 G96 L97 S98 A99 P80380 RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMRKAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGGLSA 4lf6 C 3.31 BS02 MG C 1 T165 W167 T164 W166 P80372 GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAGLARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVALNVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKVIVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAYIFLGEV 4lf6 F 3.31 BS01 NUC A 1 R2 Y4 Y50 K54 N73 R80 R87 V90 V91 K92 R2 Y4 Y50 K54 N73 R80 R87 V90 V91 K92 Q5SLP8 MRRYEVNIVLNPNLDQSQLALEKEIIQRALENYGARVEKVEELGLRRLAYPIAKDPQGYFLWYQVEMPEDRVNDLARELRIRDNVRRVMVVKSQEPFLANA 4lf6 J 3.31 BS01 NUC A 1 R5 K7 R9 H13 D17 S35 G36 P37 I38 P39 L40 P41 T42 R43 R45 T48 R51 G52 P53 F54 K55 H56 K57 R60 H62 H68 D73 E97 R3 K5 R7 H11 D15 S33 G34 P35 I36 P37 L38 P39 T40 R41 R43 T46 R49 G50 P51 F52 K53 H54 K55 R58 H60 H66 D71 E95 Q5SHN7 KIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRGPFKHKDSREHFELRTHNRLVDIINPNRKTIEQLMTLDLPTGVEIEIKT 4lf6 K 3.31 BS01 NUC A 1 Y20 N26 N27 T31 D36 G37 N38 P39 I40 W42 S44 G46 G52 S53 K55 R85 V114 P115 H116 N117 G118 C119 R120 K122 K123 K124 Y10 N16 N17 T21 D26 G27 N28 P29 I30 W32 S34 G36 G42 S43 K45 R75 V104 P105 H106 N107 G108 C109 R110 K112 K113 K114 P80376 KRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS 4lf6 M 3.31 BS01 NUC A 1 K13 R14 V17 Y23 G24 I25 G26 A28 R29 R44 L70 N77 L81 Y87 R88 R91 H92 L96 P97 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 R110 K111 R114 K115 T116 V117 K12 R13 V16 Y22 G23 I24 G25 A27 R28 R43 L69 N76 L80 Y86 R87 R90 H91 L95 P96 V97 R98 Q100 R101 T102 R103 T104 N105 A106 R107 T108 R109 K110 R113 K114 T115 V116 P80377 ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQRTRTNARTRKGPRKTVAG 4lf6 O 3.31 BS01 NUC A 1 P2 K8 Q9 I12 F18 D21 T22 G23 S24 Q28 L31 R35 R38 L39 H42 H46 D49 H50 H51 S52 R54 G55 L57 M58 G61 R64 R65 R68 Y69 P1 K7 Q8 I11 F17 D20 T21 G22 S23 Q27 L30 R34 R37 L38 H41 H45 D48 H49 H50 S51 R53 G54 L56 M57 G60 R63 R64 R67 Y68 Q5SJ76 PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHHSHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG 4lf7 C 3.15 BS02 MG C 1 V130 I157 V129 I156 P80372 GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAGLARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVALNVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKVIVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAYIFLGEV 4lf7 J 3.15 BS01 NUC A 1 R5 K7 R9 H13 D17 S35 P37 I38 P39 L40 P41 T42 R43 R45 R46 T48 R51 G52 P53 F54 K55 H56 K57 R60 H62 H68 R70 D73 E97 K99 R3 K5 R7 H11 D15 S33 P35 I36 P37 L38 P39 T40 R41 R43 R44 T46 R49 G50 P51 F52 K53 H54 K55 R58 H60 H66 R68 D71 E95 K97 Q5SHN7 KIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRGPFKHKDSREHFELRTHNRLVDIINPNRKTIEQLMTLDLPTGVEIEIKT 4lf7 K 3.15 BS01 NUC A 1 R12 Y20 N26 N27 I29 T31 D36 G37 N38 P39 I40 W42 S44 G46 K51 G52 S53 K55 R85 P113 V114 P115 H116 N117 G118 C119 R120 P121 K123 K124 R126 R2 Y10 N16 N17 I19 T21 D26 G27 N28 P29 I30 W32 S34 G36 K41 G42 S43 K45 R75 P103 V104 P105 H106 N107 G108 C109 R110 P111 K113 K114 R116 P80376 KRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS 4lf7 Q 3.15 BS01 NUC A 1 P2 K3 S12 K14 M15 Q16 K17 T18 R25 L31 Y32 K34 R38 S39 K40 K41 Y42 E61 S62 R63 P64 I65 S66 K67 R68 K69 R70 F71 R72 K87 N94 Y95 S97 L98 S99 K100 P1 K2 S11 K13 M14 Q15 K16 T17 R24 L30 Y31 K33 R37 S38 K39 K40 Y41 E60 S61 R62 P63 I64 S65 K66 R67 K68 R69 F70 R71 K86 N93 Y94 S96 L97 S98 K99 Q5SHP7 PKKVLTGVVVSDKMQKTVTVLVERQFPHPLYGKVIKRSKKYLAHDPEEKYKLGDVVEIIESRPISKRKRFRVLRLVESGRMDLVEKYLIRRQNYESLSKRG 4lf9 B 3.28 BS01 NUC A 1 K22 P26 R96 G99 G100 T103 N104 T107 R111 K133 H140 R144 Y148 I172 R175 E176 K179 K17 P21 R91 G94 G95 T98 N99 T102 R106 K128 H135 R139 Y143 I167 R170 E171 K174 P80371 TVKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ 4lf9 F 3.28 BS01 NUC A 1 R2 Y4 Y50 K54 E69 N73 R87 V90 K92 R2 Y4 Y50 K54 E69 N73 R87 V90 K92 Q5SLP8 MRRYEVNIVLNPNLDQSQLALEKEIIQRALENYGARVEKVEELGLRRLAYPIAKDPQGYFLWYQVEMPEDRVNDLARELRIRDNVRRVMVVKSQEPFLANA 4lf9 I 3.28 BS01 NUC A 1 Q3 Y5 T7 R9 R10 K11 E12 V14 R16 Y36 G39 R42 Y62 R66 G67 G68 G69 K70 S71 G72 Q73 R83 R93 K97 T103 R104 A106 R107 V108 V109 E110 R111 K112 K113 Y114 G115 H117 K118 R120 R121 A122 Q124 Y125 S126 K127 Q2 Y4 T6 R8 R9 K10 E11 V13 R15 Y35 G38 R41 Y61 R65 G66 G67 G68 K69 S70 G71 Q72 R82 R92 K96 T102 R103 A105 R106 V107 V108 E109 R110 K111 K112 Y113 G114 H116 K117 R119 R120 A121 Q123 Y124 S125 K126 P80374 EQYYGTGRRKEAVARVFLRPGNGKVTVNGQDFNEYFQGLVRAVAALEPLRAVDALGHFDAYITVRGGGKSGQIDAIKLGIARALVQYNPDYRAKLKPLGFLTRDARVVERKKYGKHKARRAPQYSKR 4lf9 K 3.28 BS01 NUC A 1 Y20 N26 N27 I29 T31 G37 N38 P39 I40 W42 S44 G46 G52 S53 K55 R85 P113 V114 H116 N117 G118 C119 R120 K122 K123 K124 R126 Y10 N16 N17 I19 T21 G27 N28 P29 I30 W32 S34 G36 G42 S43 K45 R75 P103 V104 H106 N107 G108 C109 R110 K112 K113 K114 R116 P80376 KRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS 4lf9 L 3.28 BS01 NUC A 1 P5 T6 N8 Q9 L10 R12 K13 R15 E16 K17 S22 V24 K28 G29 P31 F32 R33 R34 K46 K47 N49 S50 A51 L52 R53 K54 T61 Y69 G72 E73 R86 G87 R89 V90 K91 D92 R97 V104 R113 K114 K115 S116 R117 S118 K119 Y120 G121 T122 K123 K124 P1 T2 N4 Q5 L6 R8 K9 R11 E12 K13 S18 V20 K24 G25 P27 F28 R29 R30 K42 K43 N45 S46 A47 L48 R49 K50 T57 Y65 G68 E69 R82 G83 R85 V86 K87 D88 R93 V100 R109 K110 K111 S112 R113 S114 K115 Y116 G117 T118 K119 K120 F6DEQ7 PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEA 4lf9 O 3.28 BS01 NUC A 1 P2 K5 K8 Q9 I12 D21 T22 G23 S24 Q28 R35 L39 H42 H46 K48 D49 H50 H51 S52 R54 G55 M58 G61 Q62 R64 R65 R68 Y69 R72 P1 K4 K7 Q8 I11 D20 T21 G22 S23 Q27 R34 L38 H41 H45 K47 D48 H49 H50 S51 R53 G54 M57 G60 Q61 R63 R64 R67 Y68 R71 Q5SJ76 PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHHSHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG 4lf9 P 3.28 BS01 NUC A 1 M1 K3 R5 L6 R8 F9 G10 S11 K12 H13 N14 H16 Y17 R18 D23 R25 R26 K27 R28 G30 K31 I33 K35 Y38 P41 R42 K43 T44 T45 S61 V62 G63 Q65 T67 D68 T69 R72 R75 F80 R81 Q82 E83 M1 K3 R5 L6 R8 F9 G10 S11 K12 H13 N14 H16 Y17 R18 D23 R25 R26 K27 R28 G30 K31 I33 K35 Y38 P41 R42 K43 T44 T45 S61 V62 G63 Q65 T67 D68 T69 R72 R75 F80 R81 Q82 E83 Q5SJH3 MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLKVDVERARYWLSVGAQPTDTARRLLRQAGVFRQE 4lf9 T 3.28 BS01 NUC A 1 L10 K14 R15 H16 R17 Q18 S19 K21 R22 R23 R25 N26 K27 K29 S31 K34 T35 K38 K39 E60 S61 D64 K65 K68 S70 K74 N75 A78 R79 R80 K81 S82 R83 M85 R86 K87 R89 G102 G103 L104 S105 A106 L3 K7 R8 H9 R10 Q11 S12 K14 R15 R16 R18 N19 K20 K22 S24 K27 T28 K31 K32 E53 S54 D57 K58 K61 S63 K67 N68 A71 R72 R73 K74 S75 R76 M78 R79 K80 R82 G95 G96 L97 S98 A99 P80380 RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMRKAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGGLSA 4lfa B 3.65 BS01 NUC A 1 K22 W24 P26 R96 L98 G99 G100 T103 N104 T107 R111 K133 R144 Y148 I172 R175 E176 K179 K17 W19 P21 R91 L93 G94 G95 T98 N99 T102 R106 K128 R139 Y143 I167 R170 E171 K174 P80371 TVKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ 4lfa C 3.65 BS01 NUC A 1 G2 N3 K4 I5 F10 I14 K26 R127 S154 G155 R156 E161 Q162 A163 W167 R172 V173 P174 L175 H176 T177 L178 R179 F186 L188 R190 T191 T192 Y193 G194 V195 G197 K199 G1 N2 K3 I4 F9 I13 K25 R126 S153 G154 R155 E160 Q161 A162 W166 R171 V172 P173 L174 H175 T176 L177 R178 F185 L187 R189 T190 T191 Y192 G193 V194 G196 K198 P80372 GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAGLARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVALNVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKVIVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAYIFLGEV 4lfa E 3.65 BS01 NUC A 1 R14 T16 A17 R18 M19 Q20 A21 G22 R24 R25 R27 K47 P49 K57 Y60 Y61 G85 K92 A94 A95 T98 I101 A102 L119 T120 K121 E122 S125 R126 N127 I129 N130 Y133 R10 T12 A13 R14 M15 Q16 A17 G18 R20 R21 R23 K43 P45 K53 Y56 Y57 G81 K88 A90 A91 T94 I97 A98 L115 T116 K117 E118 S121 R122 N123 I125 N126 Y129 Q5SHQ5 DFEEKMILIRRTARMQAGGRRFRFGALVVVGDRQGRVGLGFGKAPEVPLAVQKAGYYARRNMVEVPLQNGTIPHEIEVEFGASKIVLKPAAPGTGVIAGAVPRAILELAGVTDILTKELGSRNPINIAYATMEALRQLRTKADVERLRKG 4lfa F 3.65 BS01 NUC A 1 R2 Y4 Y50 E69 N73 R87 V90 V91 K92 R2 Y4 Y50 E69 N73 R87 V90 V91 K92 Q5SLP8 MRRYEVNIVLNPNLDQSQLALEKEIIQRALENYGARVEKVEELGLRRLAYPIAKDPQGYFLWYQVEMPEDRVNDLARELRIRDNVRRVMVVKSQEPFLANA 4lfa H 3.65 BS01 NUC A 1 M1 L2 T3 D4 P5 A7 D8 T11 R12 R14 N15 V19 K21 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 V95 G96 V97 S113 T114 S115 V118 G128 V129 G130 E132 M1 L2 T3 D4 P5 A7 D8 T11 R12 R14 N15 V19 K21 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 V95 G96 V97 S113 T114 S115 V118 G128 V129 G130 E132 Q5SHQ2 MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYERVDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEIPRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW 4lfa I 3.65 BS01 NUC A 1 Q3 Y5 T7 R9 R10 K11 V14 R16 F18 R20 G39 Y62 R66 G67 G68 G69 S71 G72 Q73 R83 R93 K97 T103 R104 R107 V108 V109 E110 R111 K112 K113 Y114 G115 K116 H117 K118 R120 R121 A122 P123 Q124 Y125 Q2 Y4 T6 R8 R9 K10 V13 R15 F17 R19 G38 Y61 R65 G66 G67 G68 S70 G71 Q72 R82 R92 K96 T102 R103 R106 V107 V108 E109 R110 K111 K112 Y113 G114 K115 H116 K117 R119 R120 A121 P122 Q123 Y124 P80374 EQYYGTGRRKEAVARVFLRPGNGKVTVNGQDFNEYFQGLVRAVAALEPLRAVDALGHFDAYITVRGGGKSGQIDAIKLGIARALVQYNPDYRAKLKPLGFLTRDARVVERKKYGKHKARRAPQYSKR 4lfa L 3.65 BS01 NUC A 1 P5 T6 N8 Q9 L10 R12 K13 R15 E16 K17 V18 K21 S22 K28 G29 A30 P31 F32 R33 R34 K46 K47 N49 S50 A51 L52 R53 K54 T61 Y69 P71 G72 E73 L84 R86 G87 V90 K91 D92 P94 G95 R97 V104 R113 K114 K115 S116 R117 S118 K119 Y120 G121 T122 K123 K124 P1 T2 N4 Q5 L6 R8 K9 R11 E12 K13 V14 K17 S18 K24 G25 A26 P27 F28 R29 R30 K42 K43 N45 S46 A47 L48 R49 K50 T57 Y65 P67 G68 E69 L80 R82 G83 V86 K87 D88 P90 G91 R93 V100 R109 K110 K111 S112 R113 S114 K115 Y116 G117 T118 K119 K120 F6DEQ7 PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEA 4lfa P 3.65 BS01 NUC A 1 M1 V2 K3 R5 L6 R8 F9 G10 S11 K12 H13 N14 P15 H16 Y17 R18 D23 A24 R25 R26 K27 R28 G30 K31 I33 K35 Y38 P41 R42 K43 T44 T45 K50 Y58 W59 S61 V62 G63 Q65 T67 D68 T69 R72 R75 R81 Q82 E83 M1 V2 K3 R5 L6 R8 F9 G10 S11 K12 H13 N14 P15 H16 Y17 R18 D23 A24 R25 R26 K27 R28 G30 K31 I33 K35 Y38 P41 R42 K43 T44 T45 K50 Y58 W59 S61 V62 G63 Q65 T67 D68 T69 R72 R75 R81 Q82 E83 Q5SJH3 MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLKVDVERARYWLSVGAQPTDTARRLLRQAGVFRQE 4lfa S 3.65 BS01 NUC A 1 P2 S4 K6 K7 F10 H14 W34 R36 R37 Y52 N53 G54 K55 K70 G72 E73 T77 R78 T79 Y80 R81 P1 S3 K5 K6 F9 H13 W33 R35 R36 Y51 N52 G53 K54 K69 G71 E72 T76 R77 T78 Y79 R80 Q5SHP2 PRSLKKGVFVDDHLLEKVLELNAKGEKRLIKTWSRRSTIVPEMVGHTIAVYNGKQHVPVYITENMVGHKLGEFAPTRTYR 4lfb O 3.01 BS01 NUC A 1 P2 K5 K8 Q9 I12 F18 D21 T22 G23 S24 Q28 R35 R38 L39 H42 H46 D49 H50 H51 S52 R54 G55 M58 R64 R65 R68 Y69 R72 P1 K4 K7 Q8 I11 F17 D20 T21 G22 S23 Q27 R34 R37 L38 H41 H45 D48 H49 H50 S51 R53 G54 M57 R63 R64 R67 Y68 R71 Q5SJ76 PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHHSHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG 4lfb T 3.01 BS01 NUC A 1 L10 K14 R15 H16 R17 Q18 S19 K21 R22 R23 R25 N26 K27 K29 S31 T35 K38 K39 R57 E60 S61 D64 K65 K68 S70 K74 N75 A78 R79 K81 S82 R83 M85 K87 R89 G101 G102 G103 S105 L3 K7 R8 H9 R10 Q11 S12 K14 R15 R16 R18 N19 K20 K22 S24 T28 K31 K32 R50 E53 S54 D57 K58 K61 S63 K67 N68 A71 R72 K74 S75 R76 M78 K80 R82 G94 G95 G96 S98 P80380 RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMRKAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGGLSA 4lfc B 3.60 BS01 NUC A 1 K22 W24 P26 R96 G99 G100 T103 N104 T107 R111 K133 H140 R144 I172 R175 E176 K179 K17 W19 P21 R91 G94 G95 T98 N99 T102 R106 K128 H135 R139 I167 R170 E171 K174 P80371 TVKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ 4lfc E 3.60 BS01 NUC A 1 R14 T16 A17 R18 M19 Q20 A21 G22 R24 R25 R27 F45 K47 P49 K57 Y61 G85 A86 K92 A94 A95 T98 I101 A102 G103 L119 T120 K121 E122 S125 R126 N127 I129 N130 Y133 R10 T12 A13 R14 M15 Q16 A17 G18 R20 R21 R23 F41 K43 P45 K53 Y57 G81 A82 K88 A90 A91 T94 I97 A98 G99 L115 T116 K117 E118 S121 R122 N123 I125 N126 Y129 Q5SHQ5 DFEEKMILIRRTARMQAGGRRFRFGALVVVGDRQGRVGLGFGKAPEVPLAVQKAGYYARRNMVEVPLQNGTIPHEIEVEFGASKIVLKPAAPGTGVIAGAVPRAILELAGVTDILTKELGSRNPINIAYATMEALRQLRTKADVERLRKG 4lfc F 3.60 BS01 NUC A 1 R2 Y4 Y50 N73 R87 V90 V91 K92 R2 Y4 Y50 N73 R87 V90 V91 K92 Q5SLP8 MRRYEVNIVLNPNLDQSQLALEKEIIQRALENYGARVEKVEELGLRRLAYPIAKDPQGYFLWYQVEMPEDRVNDLARELRIRDNVRRVMVVKSQEPFLANA 4lfc K 3.60 BS02 MG K 1 A100 S101 G102 L103 A90 S91 G92 L93 P80376 KRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS 4lfc O 3.60 BS01 NUC A 1 P2 K8 Q9 I12 F18 D21 T22 G23 S24 T25 Q28 L31 R35 L39 H42 H46 D49 H50 H51 S52 R54 G55 L57 M58 G61 R64 R65 L66 R68 Y69 P1 K7 Q8 I11 F17 D20 T21 G22 S23 T24 Q27 L30 R34 L38 H41 H45 D48 H49 H50 S51 R53 G54 L56 M57 G60 R63 R64 L65 R67 Y68 Q5SJ76 PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHHSHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG 4lg0 A 2.19 BS01 NUC C 1 L183 Y187 N204 S205 R214 H215 S218 R225 S235 W237 L28 Y32 N49 S50 R59 H60 S63 R70 S80 W82 Q12778 RRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGG 4lg0 A 2.19 BS02 NUC D 1 N158 S164 Y165 N211 S212 H215 N3 S9 Y10 N56 S57 H60 Q12778 RRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGG 4lg0 B 2.19 BS02 NUC D 1 G333 Y386 R391 R394 Y395 Y397 K404 K408 R409 Y410 G1 Y54 R59 R62 Y63 Y65 K72 K76 R77 Y78 P14921 GPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPD 4lhg X 1.98 BS01 PDA X 1 K42 T69 S70 N72 T73 Q143 V176 G177 T178 G179 G180 S181 Q227 G228 I229 S272 P299 S300 Y305 K41 T68 S69 N71 T72 Q142 V175 G176 T177 G178 G179 S180 Q226 G227 I228 S271 P298 S299 Y304 2.5.1.47 P45040 AIYADNSYSIGNTPLVRLKHFGHNGNVVVKIEGRNPSYSVKCRIGANMVWQAEKDGTLTKGKEIVDATSGNTGIALAYVAAARGYKITLTMPETMSLERKRLLCGLGVNLVLTEGAKGMKGAIAKAEEIVASDPSRYVMLKQFENPANPQIHRETTGPEIWKDTDGKVDVVVAGVGTGGSITGISRAIKLDFGKQITSVAVEPVESPVISQTLAGEEVKPGPHKIQGIGAGFIPKNLDLSIIDRVETVDSDTALATARRLMAEEGILAGISSGAAVAAADRLAKLPEFADKLIVVILPSASERYLSTALFEG 4lrq A 1.45 BS01 MPO A 1 C8 M9 G10 N11 I12 C13 R14 I41 Y43 H44 D122 Y124 C7 M8 G9 N10 I11 C12 R13 I40 Y42 H43 D121 Y123 3.1.3.48 A5F2Q3 24909685 QKVLVVCMGNICRSPTAEAVLRAKAAQLKVDVEVDSAGTIGYHQGNPPDARSKAAGEKRGYSFSGIKARKIRDEDFVKFDWILAADQENLAELKARCPQSHQHKLSLMLSHSDSEYQEIPDPYYGGERGFELVLDLVEDAAEQFLLKL 4ltc K 2.50 BS01 EC6 K 1 T1 R19 A20 T21 A27 K33 G47 A49 S96 S131 Y170 T1 R19 A20 T21 A27 K33 G47 A49 S96 S131 Y170 3.4.25.1 P30656 24930969 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4ltc Y 2.50 BS01 EC6 Y 1 T1 R19 A20 T21 K33 G47 A49 S131 Y170 T1 R19 A20 T21 K33 G47 A49 S131 Y170 3.4.25.1 P30656 24930969 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4lwv A 2.32 BS01 20W A 1 L50 L53 G54 I57 M58 Y63 H69 F82 V89 K90 H92 I95 Y96 L30 L33 G34 I37 M38 Y43 H49 F62 V69 K70 H72 I75 Y76 6.3.2.- P56273 24900784 EKLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQLYDEKQQHIVHCSNDPLGELFGVQEFSVKEHRRIYAMISRNLVS 4lwv B 2.32 BS01 20W B 1 L50 G54 I57 M58 Y63 Q68 F87 V89 K90 H92 I95 Y96 L30 G34 I37 M38 Y43 Q48 F67 V69 K70 H72 I75 Y76 6.3.2.- P56273 24900784 EKLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQLYDEKQQHIVHCSNDPLGELFGVQEFSVKEHRRIYAMISRNLVS 4lwv C 2.32 BS01 20W C 1 L50 L53 G54 I57 M58 H69 F82 F87 V89 K90 H92 I95 Y96 L30 L33 G34 I37 M38 H49 F62 F67 V69 K70 H72 I75 Y76 6.3.2.- P56273 24900784 EKLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQLYDEKQQHIVHCSNDPLGELFGVQEFSVKEHRRIYAMISRNLVS 4mag A 1.45 BS01 CO A 1 H302 H305 H307 H302 H305 H307 C3NPP8 ATTLKMGMQASVGSVEYNSAKMLADTLEEMSQGEIKLALYPSAQLGDDRAMLQQLTLGDLDITYAEFGRMGLWIPRAEAVMLPYVAKDFDHLRRMFESDFGQGVRDEMLQKFNWRALDTWYNGTRETTSNRPLNSIEDFKGLKLRVPNAKQNLNYAKLSGASPTPMSFSEVYLALQTNAVDGQENPLPTIKTMKFYEVQKNLAMTHHIVNDQMVIISESTWQKLSDTDKDIIQKAVQKVGDAHTQTVKTQEAELVSFFKSEGINVTYPDLEPFREAMQPLYKEFDSNIGQPIVSKLAAMLQHHHHHH 4mbe A 2.61 BS02 CA A 2 D142 D144 D146 E148 E153 D130 D132 D134 E136 E141 P06704 LNSELLEEQKQEIYEAFSLFDMNNDGFLDYHELKVAMKALGFELPKREILDLIDEYDSEGRHLMKYDDFYIVMGEKILKRDPLDEIKRAFQLFDDDHTGKISIKNLRRVAKELGETLTDEELRAMIEEFDLDGDGEINENEFIAICTDS 4mbe B 2.61 BS01 III G 1 L768 A771 F772 H774 E775 Y778 L13 A16 F17 H19 E20 Y23 P46674 YRKDFIDTMTRELYDAFLHERLYLIYMDSRAELKRNSTLKKKFFEKWQAS 4mbe C 2.61 BS01 III G 1 K9 S10 Q13 V17 Y22 K8 S9 Q12 V16 Y21 Q6WNK7 TMDTAQLKSQIQQYLVESGNYELISNELKARLLQEGWVDKVKDLTKSEMNINESTNFTQILSTVEPKALEMVSDSTRETVLKQIREFLEEIVDT 4mbe D 2.61 BS02 CA D 2 D33 M34 N35 D37 F39 E44 D21 M22 N23 D25 F27 E32 P06704 LNSELLEEQKQEIYEAFSLFDMNNDGFLDYHELKVAMKALGFELPKREILDLIDEYDSEGRHLMKYDDFYIVMGEKILKRDPLDEIKRAFQLFDDDHTGKISIKNLRRVAKELGETLTDEELRAMIEEFDLDGDGEINENEFIAICTDS 4mbe E 2.61 BS01 III H 1 M764 E767 L768 A771 F772 H774 E775 Y778 M10 E13 L14 A17 F18 H20 E21 Y24 P46674 NYRKDFIDTMTRELYDAFLHERLYLIYMDSRAELKRNSTLKKKFFEKWQAS 4mbe F 2.61 BS01 III H 1 K9 Q13 L16 V17 Y22 E23 K2 Q6 L9 V10 Y15 E16 Q6WNK7 LKSQIQQYLVESGNYELISNELKARLLQEGWVDKVKDLTKSEMNINESTNFTQILSTVEPKALEMVSDSTRETVLKQIREFLEEIVDT 4mbe F 2.61 BS02 III Y 1 Y15 I92 V93 Y8 I85 V86 Q6WNK7 LKSQIQQYLVESGNYELISNELKARLLQEGWVDKVKDLTKSEMNINESTNFTQILSTVEPKALEMVSDSTRETVLKQIREFLEEIVDT 4mlt A 2.00 BS02 TM4 A 1 H94 H119 V121 L198 T199 T200 H91 H116 V118 L194 T195 T196 4.2.1.1 P00918 24635441 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4mnd A 2.66 BS01 MG A 1 D357 D360 D378 D280 D283 D301 2.7.7.74,2.7.8.34 O29976 24942835 LMKAVILAAGLGGGVPKPLVRVGGCEIILRTMKLLSPHVSEFIIVASRYADDIDAFLKDKGFNYKIVRHDRPEKGNGYSLLVAKNHVEDRFILTMGDHVYSQQFIEKAVRGEGVIADREPRFVDIGEATKIRVEDGRVAKIGKDLREFDCVDTGFFVLDDSIFEHAEKLRDREEIPLSEIVKLARLPVTYVDGELWMDVDTKEDVRRANRALVSAAVGDGFISRKINRKISTRISAAIVNKVNPNQMTLISFLVGAFSALASFFSIPLAGLLYQFSSILDGCDGEIARASLKMSKKGGYVDSILDRFVDFLFLAIIALLYPKTATVAMFAIFGSVMVSYTSEKYKAEFGESIRVLNYIPGKRDERIFLIMIFCLLSAISLQWIFWMFLFVAAISLTRVVVTLLAVLVS 4mqv A 1.95 BS01 III B 1 P222 S250 N251 E252 G253 H254 I255 Y256 S257 T258 V259 S266 T267 P19 S47 N48 E49 G50 H51 I52 Y53 S54 T55 V56 S63 T64 P15927 24910198 GLTVAQNQVLNLIKACPRPEGLNFQDLKNQLKHMSVSSIKQAVDFLSNEGHIYSTVDDDHFKSTD 4mqv C 1.95 BS01 III D 1 P222 N251 E252 G253 H254 Y256 S257 T258 V259 T267 D268 P19 N48 E49 G50 H51 Y53 S54 T55 V56 T64 D65 P15927 24910198 GLTVAQNQVLNLIKACPRPEGLNFQDLKNQLKHMSVSSIKQAVDFLSNEGHIYSTVDDDHFKSTD 4n02 A 1.40 BS01 SO4 A 1 F54 Q294 K297 F53 Q293 K296 5.3.3.2 B2ILS5 24910111 TTNRKDEHILYALEQKSSYNSFDEVELIHSSLPLYNLDEIDLSTEFAGRKWDFPFYINAMTGGSNKGREINQKLAQVAESCGILFVTGSYSAALKNPTDDSFSVKSSHPNLLLGTNIGLDKPVELGLQTVEEMNPVLLQVHVNVMQELLMPEGERKFRSWQSHLADYSKQIPVPIVLKEVGFGMDAKTIERAYEFGVRTVDLSGRGGTSFAYIENRRSGQRDYLNQWGQSTMQALLNAQEWKDKVELLVSGGVRNPLDMIKCLVFGAKAVGLSRTVLELVETYTVEEVIGIVQGWKADLRLIMCSLNCATIADLQKVDYLLYGKLKEAKDQM 4n02 A 1.40 BS02 SO4 A 2 R5 K6 S90 S92 A93 R4 K5 S89 S91 A92 5.3.3.2 B2ILS5 24910111 TTNRKDEHILYALEQKSSYNSFDEVELIHSSLPLYNLDEIDLSTEFAGRKWDFPFYINAMTGGSNKGREINQKLAQVAESCGILFVTGSYSAALKNPTDDSFSVKSSHPNLLLGTNIGLDKPVELGLQTVEEMNPVLLQVHVNVMQELLMPEGERKFRSWQSHLADYSKQIPVPIVLKEVGFGMDAKTIERAYEFGVRTVDLSGRGGTSFAYIENRRSGQRDYLNQWGQSTMQALLNAQEWKDKVELLVSGGVRNPLDMIKCLVFGAKAVGLSRTVLELVETYTVEEVIGIVQGWKADLRLIMCSLNCATIADLQKVDYLLYGKLKEAKDQM 4n02 A 1.40 BS03 FNR A 1 H9 I10 A13 A60 M61 G89 S90 N117 H142 K179 V181 S204 G208 T209 F211 G252 G253 S274 R275 H8 I9 A12 A59 M60 G88 S89 N116 H141 K178 V180 S203 G207 T208 F210 G251 G252 S273 R274 5.3.3.2 B2ILS5 24910111 TTNRKDEHILYALEQKSSYNSFDEVELIHSSLPLYNLDEIDLSTEFAGRKWDFPFYINAMTGGSNKGREINQKLAQVAESCGILFVTGSYSAALKNPTDDSFSVKSSHPNLLLGTNIGLDKPVELGLQTVEEMNPVLLQVHVNVMQELLMPEGERKFRSWQSHLADYSKQIPVPIVLKEVGFGMDAKTIERAYEFGVRTVDLSGRGGTSFAYIENRRSGQRDYLNQWGQSTMQALLNAQEWKDKVELLVSGGVRNPLDMIKCLVFGAKAVGLSRTVLELVETYTVEEVIGIVQGWKADLRLIMCSLNCATIADLQKVDYLLYGKLKEAKDQM 4n7z A 2.85 BS01 III B 1 K600 P601 I602 R603 Q604 T606 K607 K608 A609 K625 K634 R684 K685 Y688 R691 L695 V696 K699 P701 F706 G804 R805 K15 P16 I17 R18 Q19 T21 K22 K23 A24 K40 K49 R97 K98 Y101 R104 L108 V109 K112 P114 F119 G217 R218 2.7.11.21 O00444 TLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRK 4nc7 A 2.00 BS01 I3C A 1 Q33 E34 N37 K47 Y81 Q31 E32 N35 K45 Y79 P12464 24937760 KQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLLGVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWY 4nc7 A 2.00 BS02 NI A 1 L61 N62 D64 F67 L59 N60 D62 F65 P12464 24937760 KQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLLGVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWY 4o0j A 2.05 BS01 LF8 A 1 L102 T124 T125 A128 A129 W132 L47 T69 T70 A73 A74 W77 P12497 24874515 CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNKKRKGGGYSAGERIVDIIATDIQ 4o55 A 2.24 BS01 LF9 A 1 Q95 T124 T125 A128 A129 Q40 T69 T70 A73 A74 P12497 24874515 CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNKKRKGGGYSAGERIVDIIATDIQ 4o5b A 2.37 BS01 LF9 A 1 Q95 T124 T125 T128 A129 Q40 T69 T70 T73 A74 P12497 24874515 CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKTACWWAGIKQEFGIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNKKRKGGYSAGERIVDIIATDIQ 4o5c A 2.36 BS01 NUC T 1 H34 S229 K230 G231 E232 T233 K234 Y271 E295 Y296 H28 S221 K222 G223 E224 T225 K226 Y263 E287 Y288 2.7.7.7,4.2.99.- P06746 PQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4o5e A 2.53 BS04 1FZ A 1 R149 G179 S180 R183 G189 D190 Y271 G274 S275 D276 N279 R143 G173 S174 R177 G183 D184 Y263 G266 S267 D268 N271 2.7.7.7,4.2.99.- P06746 PQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4o5k A 2.06 BS01 NUC T 1 H34 S229 K230 G231 E232 T233 K234 R258 K280 R283 L287 T292 I293 N294 E295 Y296 H25 S220 K221 G222 E223 T224 K225 R249 K271 R274 L278 T283 I284 N285 E286 Y287 2.7.7.7,4.2.99.- P06746 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4o5k A 2.06 BS02 NUC P 1 G105 G107 P108 S109 A110 R254 D256 Y271 F272 G96 G98 P99 S100 A101 R245 D247 Y262 F263 2.7.7.7,4.2.99.- P06746 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4o5k A 2.06 BS06 0KX A 1 G179 S180 R183 S188 G189 D190 D192 Y271 F272 G274 S275 D276 N279 G170 S171 R174 S179 G180 D181 D183 Y262 F263 G265 S266 D267 N270 2.7.7.7,4.2.99.- P06746 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4o8n A 1.65 BS01 CA A 1 Q216 H280 Q190 H254 Q76BV4 24951792 CELPSTYRWTSTGALAQPRSGWVSLKDFTVVPYNGQHLVYATTHDTGTRWGSMNFEPFGDWSQMATARQNAMNSPTVAPTLFYFAPKDIWVLAYQWGGSAFSYRTSHDPTDPNGWSSEQVLFSGSIADSATGPIDQTLIGDDTHMYLFFAGDNGKIYRASMPIGDFPGSFGSTATVVMSDTRNNLFEAPQVYKLQGQNRYLMIVEAIGAQGQRYFRSFTATSLDGEWTPQATSESNPFAGKANSGATWTDDISHGELIRTTADQTMTVDPCNLQLLYQGRDPGSGGTYDLLPYRPGLLTLQR 4o8o A 1.21 BS02 AHR A 1 K87 D88 W111 A139 Q156 I195 D196 E248 H315 Y349 K27 D28 W51 A79 Q96 I135 D136 E188 H255 Y289 Q76BV4 24951792 SCELPSTYRWTSTGALAQPRSGWVSLKDFTVVPYNGQHLVYATTHDTGTRWGSMNFEPFGDWSQMATARQNAMNSPTVAPTLFYFAPKDIWVLAYQWGGSAFSYRTSHDPTDPNGWSSEQVLFSGSIADSATGPIDQTLIGDDTHMYLFFAGDNGKIYRASMPIGDFPGSFGSTATVVMSDTRNNLFEAPQVYKLQGQNRYLMIVEAIGAQGQRYFRSFTATSLDGEWTPQATSESNPFAGKANSGATWTDDISHGELIRTTADQTMTVDPCNLQLLYQGRDPGSGGTYDLLPYRPGLLTLQR 4o8p A 1.56 BS01 CA A 1 Q197 Q251 H315 Q137 Q191 H255 Q76BV4 24951792 SCELPSTYRWTSTGALAQPRSGWVSLKDFTVVPYNGQHLVYATTHDTGTRWGSMNFEPFGDWSQMATARQNAMNSPTVAPTLFYFAPKDIWVLAYQWGGSAFSYRTSHDPTDPNGWSSEQVLFSGSIADSATGPIDQTLIGDDTHMYLFFAGDNGKIYRASMPIGDFPGSFGSTATVVMSDTRNNLFEAPQVYKLQGQNRYLMIVEAIGAQGQRYFRSFTATSLDGEWTPQATSESNPFAGKANSGATWTDDISHGELIRTTADQTMTVDPCNLQLLYQGRDPGSGGTYDLLPYRPGLLTLQR 4o8p A 1.56 BS02 XYP A 1 W111 W157 W51 W97 Q76BV4 24951792 SCELPSTYRWTSTGALAQPRSGWVSLKDFTVVPYNGQHLVYATTHDTGTRWGSMNFEPFGDWSQMATARQNAMNSPTVAPTLFYFAPKDIWVLAYQWGGSAFSYRTSHDPTDPNGWSSEQVLFSGSIADSATGPIDQTLIGDDTHMYLFFAGDNGKIYRASMPIGDFPGSFGSTATVVMSDTRNNLFEAPQVYKLQGQNRYLMIVEAIGAQGQRYFRSFTATSLDGEWTPQATSESNPFAGKANSGATWTDDISHGELIRTTADQTMTVDPCNLQLLYQGRDPGSGGTYDLLPYRPGLLTLQR 4o8p A 1.56 BS03 XYP A 2 W111 W157 D350 W51 W97 D290 Q76BV4 24951792 SCELPSTYRWTSTGALAQPRSGWVSLKDFTVVPYNGQHLVYATTHDTGTRWGSMNFEPFGDWSQMATARQNAMNSPTVAPTLFYFAPKDIWVLAYQWGGSAFSYRTSHDPTDPNGWSSEQVLFSGSIADSATGPIDQTLIGDDTHMYLFFAGDNGKIYRASMPIGDFPGSFGSTATVVMSDTRNNLFEAPQVYKLQGQNRYLMIVEAIGAQGQRYFRSFTATSLDGEWTPQATSESNPFAGKANSGATWTDDISHGELIRTTADQTMTVDPCNLQLLYQGRDPGSGGTYDLLPYRPGLLTLQR 4o8p A 1.56 BS04 XYP A 3 D213 F247 E248 R274 Y349 D153 F187 E188 R214 Y289 Q76BV4 24951792 SCELPSTYRWTSTGALAQPRSGWVSLKDFTVVPYNGQHLVYATTHDTGTRWGSMNFEPFGDWSQMATARQNAMNSPTVAPTLFYFAPKDIWVLAYQWGGSAFSYRTSHDPTDPNGWSSEQVLFSGSIADSATGPIDQTLIGDDTHMYLFFAGDNGKIYRASMPIGDFPGSFGSTATVVMSDTRNNLFEAPQVYKLQGQNRYLMIVEAIGAQGQRYFRSFTATSLDGEWTPQATSESNPFAGKANSGATWTDDISHGELIRTTADQTMTVDPCNLQLLYQGRDPGSGGTYDLLPYRPGLLTLQR 4o8p A 1.56 BS05 XYP A 4 R243 F247 R274 R183 F187 R214 Q76BV4 24951792 SCELPSTYRWTSTGALAQPRSGWVSLKDFTVVPYNGQHLVYATTHDTGTRWGSMNFEPFGDWSQMATARQNAMNSPTVAPTLFYFAPKDIWVLAYQWGGSAFSYRTSHDPTDPNGWSSEQVLFSGSIADSATGPIDQTLIGDDTHMYLFFAGDNGKIYRASMPIGDFPGSFGSTATVVMSDTRNNLFEAPQVYKLQGQNRYLMIVEAIGAQGQRYFRSFTATSLDGEWTPQATSESNPFAGKANSGATWTDDISHGELIRTTADQTMTVDPCNLQLLYQGRDPGSGGTYDLLPYRPGLLTLQR 4o9s A 2.30 BS01 2RY A 1 L35 F36 L37 F45 A55 A57 M73 V74 G75 M88 Y90 F96 D102 R121 Y133 F135 L35 F36 L37 F45 A55 A57 M73 V74 G75 M88 Y90 F96 D102 R121 Y133 F135 P02753 24835984 ERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCD 4ocx H 2.39 BS01 MT1 L 1 P32 Y33 A34 N36 Y51 Y99 P32 Y33 A34 N36 Y51 Y99 24832237 DVQLQESGPGLVKPSQSLSLTCTVTGFSITSPYAWNWIRQFPGNTLEWMGYISYRGSTTYHPSLKSRISITRDTSKNQFFLQLNSVTTEDTATYFCSSYGNYGAYSGQGTLVTVSAAKTTPPSVYPLAPGSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR 4ocx L 2.39 BS01 MT1 L 1 H31 Y37 E39 Y41 F94 G96 L101 H31 Y37 E39 Y41 F94 G96 L101 24832237 DVLLTQIPLSLPVSLGDQASISCRSSQSIVHSNGNTYLEWYLQKPGQSPKLLIYKVSTRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPLTFGAGTQLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSPIVKSFNR 4okd A 2.40 BS01 GLC A 1 W329 Y331 H382 C418 R450 D452 L453 E527 H619 D620 W255 Y257 H308 C344 R376 D378 L379 E453 H545 D546 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS02 GLC A 2 Y314 W329 Y331 C418 N704 Y240 W255 Y257 C344 N630 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS03 GLC A 3 Y314 G417 E640 Y706 Y240 G343 E566 Y632 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS04 GLC A 4 G417 C418 G419 G343 C344 G345 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS05 GLC A 5 G386 N387 R389 G390 G312 N313 R315 G316 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS06 GLC A 6 W229 E313 W155 E239 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS07 GLC A 7 M226 T228 Y315 M152 T154 Y241 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS08 GLC A 8 W529 D530 N535 R555 W455 D456 N461 R481 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS09 GLC A 9 G571 A574 S575 W757 W767 G497 A500 S501 W683 W693 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS10 GLC A 10 C578 P581 I755 W757 C504 P507 I681 W683 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS11 GLC A 11 K563 G564 W652 K489 G490 W578 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd A 2.40 BS12 GLC A 12 R772 H794 R698 H720 3.2.1.68 Q7X8Q2 KLFCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANGENNRDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd B 2.40 BS01 GLC B 1 Y331 H382 C418 D452 L453 E527 H619 D620 Y253 H304 C340 D374 L375 E449 H541 D542 3.2.1.68 Q7X8Q2 FCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAASAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd B 2.40 BS02 GLC B 2 Y314 W329 Y331 N704 Y706 Y236 W251 Y253 N621 Y623 3.2.1.68 Q7X8Q2 FCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAASAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd B 2.40 BS03 GLC B 3 Y314 G417 Y706 Y236 G339 Y623 3.2.1.68 Q7X8Q2 FCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAASAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd B 2.40 BS07 GLC B 7 M226 T228 L312 Y315 M150 T152 L234 Y237 3.2.1.68 Q7X8Q2 FCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAASAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4okd B 2.40 BS09 GLC B 9 C578 P581 V750 N751 D752 I755 W757 C500 P503 V667 N668 D669 I672 W674 3.2.1.68 Q7X8Q2 FCEPSGQPASTAYGPALTGRPAPLGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIMLPDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVMPTWPQAAAALPAASAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLASILTRAHSAWHPQQYDQETGQRVAMSSGGAIVTAEGIMTDGAGVPTGYPLADPPLVESISEDPVLRNTKMIAEAWDCDGLNQVGAFPHYGGRWSEWNGKFRDVVRNFIKGTDGPWAGDFASAICGSPNIYANNTPHETDWWANNGGRQWKGGRGPHASINFVAAHDGFTLADMVAYNNKHNEANDGEQHNNSWNCGEEGPTTKWEVNRLRQRQMRNLTGALLLSCGVPMINMGDEYGHSKNGNNNTYCHDSELNYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWTDTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVWQPLVDTSKVAPYDFLAVDGVLSAEDVAAARRQMAMWTADHTYPVLPWSCIVLQSAPEDPAATSMIK 4oo1 E 3.30 BS01 MG E 1 D81 I82 Q85 D87 D80 I81 Q84 D86 Q12277 SLSVAEKSYLYDSLASTPSIRPDGRLPHQFRPIEIFTDFLPSSNGSSRIIASDGSECIVSIKSKVVDHHVENELLQVDVDIAGQRDDALVVETITSLLNKVLKSGSGVDSSKLQLTKKYSFKIFVDVLVISSHSHPVSLISFAIYSALNSTYLPKLISAFPTFHDYDMVKLDINPPLVFILAVVGNNMLLDPAANESEVANNGLIISWSNGKITSPIRSVALNDSNVKSFKPHLLKQGLAMVEKYAPDVVRSLEN 4oo1 J 3.30 BS01 NUC S 1 N238 L239 E240 H241 H291 G292 F294 M295 D296 W299 Y315 K319 R325 H326 S327 L328 Q345 Y361 N111 L112 E113 H114 H164 G165 F167 M168 D169 W172 Y188 K192 R198 H199 S200 L201 Q218 Y234 3.1.13.- Q12149 MVEKPQLKFKSPIDNSESHPFIPLLKEKPNALKPLSESLRLVDDDENNPSHYPHPYEYEIDHQEYSPEILQIREEIPSKSWDDSVPIWVDTSTELESMLEDLKNTKEIAVNLEHHDYRSYYGIVCLMQISTRERDYLVDTLKLRENLHILNEVFTNPSIVKVFHGAFMDIIWLQRDLGLYVVGLFDTYHASKAIGLPRHSLAYLLENFANFKTSKKYQLADWRIRPLSKPMTAYARADTHFLLNIYDQLRNKLIESNKLAGVLYESRNVAKRRFEYSKYRPLTPSSEVYSPIEKESPWKILMYQYNIPPEREVLVRELYQWRDLIARRDDESPRFVMPNQLLAALVAYTPTDVIGVVSLTNGVTEHVRQNAKLLANLIRDALRNIKNTNSETKADGILLETISVPQIRDVMERFSVLCNSNISKSRAKPVTNSSILLGKILPREEHDIAYSKDGLPNKVKTEDIRIRAQNFKSALANLEDIIFEIEKPLVVPV 4oo9 A 2.60 BS01 2U8 A 1 G624 I625 I651 S654 P655 S658 Y659 V740 P743 L744 N747 W785 F788 M802 S805 V806 S809 A810 A813 G57 I58 I84 S87 P88 S91 Y92 V317 P320 L321 N324 W362 F365 M379 S382 V383 S386 A387 A390 3.2.1.17 P41594 2014 SPVQYLRWGDPAPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTYRAARILAMSKKNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKISACAQLVIAFILICIQLGIIVALFIMEPPDIMVYLICNTTNLGVVAPLGYNGLLILACTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERN 4opx A 3.31 BS01 NUC N 1 K15 S16 A19 S20 R34 V48 W51 S274 G275 K10 S11 A14 S15 R29 V43 W46 S137 G138 P09874 24922587 DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEASKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPP 4opx A 3.31 BS02 ZN A 1 C21 C24 H53 C56 C16 C19 H48 C51 P09874 24922587 DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEASKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPP 4opx A 3.31 BS03 ZN A 2 C295 C298 C311 C321 C158 C161 C174 C184 P09874 24922587 DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEASKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPP 4opx C 3.31 BS02 2UR C 1 H862 G863 Y896 F897 A898 K903 S904 Y907 H307 G308 Y341 F342 A343 K348 S349 Y352 2.4.2.30 P09874 24922587 AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 4opx F 3.31 BS01 NUC N 1 Y570 W589 K600 K621 F638 Y40 W51 K62 K83 F100 2.4.2.30 P09874 24922587 AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 4oqa C 3.65 BS02 2US C 1 H862 G863 Y889 Y896 A898 S904 Y907 E988 H307 G308 Y334 Y341 A343 S349 Y352 E433 2.4.2.30 P09874 24922587 AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 4oqb C 3.36 BS02 2UT C 1 D766 H862 G863 R878 Y889 Y896 A898 S904 Y907 E988 D211 H307 G308 R323 Y334 Y341 A343 S349 Y352 E433 2.4.2.30 P09874 24922587 AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 4ork A 2.30 BS01 GDP A 1 I34 G37 D39 S40 A42 I50 K52 Y100 E102 I103 F107 H205 I218 D219 I29 G32 D34 S35 A37 I45 K47 Y95 E97 I98 F102 H200 I213 D214 2.3.1.-,2.7.1.- P0A0C1 24914967 DDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK 4ork A 2.30 BS02 MG A 1 H205 D219 H200 D214 2.3.1.-,2.7.1.- P0A0C1 24914967 DDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK 4ork A 2.30 BS03 MG A 2 D200 D219 D195 D214 2.3.1.-,2.7.1.- P0A0C1 24914967 DDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK 4ork B 2.30 BS01 GDP B 1 I34 G35 S36 G37 D39 S40 A42 I50 K52 Y100 I103 F107 H205 I218 D219 I29 G30 S31 G32 D34 S35 A37 I45 K47 Y92 I95 F99 H197 I210 D211 2.3.1.-,2.7.1.- P0A0C1 24914967 DDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK 4ork C 2.30 BS01 GDP C 1 I34 S36 G37 S40 A42 I50 K52 Y100 I103 F107 H205 I218 D219 I26 S28 G29 S32 A34 I42 K44 Y89 I92 F96 H194 I207 D208 2.3.1.-,2.7.1.- P0A0C1 24914967 ATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK 4ork D 2.30 BS01 GDP D 1 G35 S36 G37 S40 A42 I50 K52 Y100 I103 F107 H205 L207 I218 D219 G27 S28 G29 S32 A34 I42 K44 Y90 I93 F97 H195 L197 I208 D209 2.3.1.-,2.7.1.- P0A0C1 24914967 ATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD 4otp A 2.70 BS01 ADP A 1 I186 S187 V194 K208 P265 M277 S278 I280 L289 N329 I340 D341 I24 S25 V32 K46 P71 M83 S84 I86 L95 N135 I146 D147 2.7.11.1 Q9BRS2 24948609 DPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAIKIYKKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSVAVMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHVDEEVFKRAYI 4otp A 2.70 BS02 MG A 1 N329 D341 N135 D147 2.7.11.1 Q9BRS2 24948609 DPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAIKIYKKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSVAVMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHVDEEVFKRAYI 4ov6 B 2.69 BS01 PG4 B 1 Q413 I416 L440 Q248 I251 L275 3.4.21.- Q8NBP7 24917546 SIPWNLERITPPSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPP 4ov6 D 2.69 BS01 PG4 D 1 L108 K125 M126 L49 K66 M67 Q8NBP7 24917546 TTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQ 4ozj A 1.45 BS01 ADP A 1 I18 G46 R47 G48 S49 K97 G98 D99 G100 K101 I13 G41 R42 G43 S44 K78 G79 D80 G81 K82 B8ZYW1 24946894 LPNDGGIKLVMAIIRPDKLADVKTALAEVGAPSLTVTNVSGRGSVDLHQKVKVECVVADTPAEDVADAIADAAHTGEKGDGKIFILPVENAIQVRTGKTGRDAV 4ozl A 1.49 BS01 AMP A 1 I18 G46 R47 G48 G98 D99 G100 K101 I14 G42 R43 G44 G79 D80 G81 K82 B8ZYW1 24946894 DLPNDGGIKLVMAIIRPDKLADVKTALAEVGAPSLTVTNVSGRGSDLHQKVKVECVVADTPAEDVADAIADAAHTGEKGDGKIFILPVENAIQVRTGKTGRDAV 4ozn A 2.60 BS01 ATP A 1 I18 G46 R47 G48 S49 G98 D99 G100 K101 I14 G42 R43 G44 S45 G91 D92 G93 K94 B8ZYW1 24946894 DLPNDGGIKLVMAIIRPDKLADVKTALAEVGAPSLTVTNVSGRGSQKSQWRGEEYTVDLHQKVKVECVVADTPAEDVADAIADAAHTGEKGDGKIFILPVENAIQVRTGKTGRDAV 4ozn A 2.60 BS02 ATP C 1 S38 L39 T40 E73 V75 Q112 R114 S34 L35 T36 E66 V68 Q105 R107 B8ZYW1 24946894 DLPNDGGIKLVMAIIRPDKLADVKTALAEVGAPSLTVTNVSGRGSQKSQWRGEEYTVDLHQKVKVECVVADTPAEDVADAIADAAHTGEKGDGKIFILPVENAIQVRTGKTGRDAV 4ozn B 2.60 BS01 ATP A 1 S38 L39 T40 E73 C74 V75 R114 S34 L35 T36 E54 C55 V56 R95 B8ZYW1 24946894 DLPNDGGIKLVMAIIRPDKLADVKTALAEVGAPSLTVTNVSGRGSDLHQKVKVECVVADTPAEDVADAIADAAHTGEKGDGKIFILPVENAIQVRTGKTGRDAV 4ozn B 2.60 BS02 ATP B 1 I18 G46 R47 G48 S49 K97 G98 D99 G100 K101 I14 G42 R43 G44 S45 K78 G79 D80 G81 K82 B8ZYW1 24946894 DLPNDGGIKLVMAIIRPDKLADVKTALAEVGAPSLTVTNVSGRGSDLHQKVKVECVVADTPAEDVADAIADAAHTGEKGDGKIFILPVENAIQVRTGKTGRDAV 4ozn C 2.60 BS01 ATP B 1 S38 L39 T40 E73 C74 V75 Q112 R114 S35 L36 T37 E63 C64 V65 Q102 R104 B8ZYW1 24946894 ADLPNDGGIKLVMAIIRPDKLADVKTALAEVGAPSLTVTNVSGRGSQRGEEYTVDLHQKVKVECVVADTPAEDVADAIADAAHTGEKGDGKIFILPVENAIQVRTGKTGRDAV 4ozn C 2.60 BS02 ATP C 1 I18 G46 R47 G48 S49 K69 K97 G98 G100 K101 I15 G43 R44 G45 S46 K59 K87 G88 G90 K91 B8ZYW1 24946894 ADLPNDGGIKLVMAIIRPDKLADVKTALAEVGAPSLTVTNVSGRGSQRGEEYTVDLHQKVKVECVVADTPAEDVADAIADAAHTGEKGDGKIFILPVENAIQVRTGKTGRDAV 4p0v A 2.40 BS02 1WO A 1 G56 K57 Y58 R60 E93 Q96 R112 R113 F239 D243 K257 K353 G49 K50 Y51 R53 E86 Q89 R105 R106 F232 D236 K250 K346 2.5.1.10,2.5.1.1 P14324 24927548 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 4p0w A 2.41 BS01 1XH A 1 G56 K57 Y58 N59 R60 G61 E93 Q96 L100 R112 R113 F239 G49 K50 Y51 N52 R53 G54 E86 Q89 L93 R105 R106 F232 2.5.1.10,2.5.1.1 P14324 24927548 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 4p0x A 2.50 BS01 1WO A 1 G56 K57 Y58 N59 R60 L100 R113 F239 D243 G43 K44 Y45 N46 R47 L85 R98 F221 D225 2.5.1.10,2.5.1.1 P14324 24927548 AQEKQDFVQHFSQIVRVLTEGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRAPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIY 4p0x A 2.50 BS02 1WO A 2 N59 K347 N46 K328 2.5.1.10,2.5.1.1 P14324 24927548 AQEKQDFVQHFSQIVRVLTEGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRAPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIY 4p5o B 3.11 BS01 ZN B 1 C42 C45 H80 C83 C20 C23 H51 C54 6.3.2.- P62877 24949976 EVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQ 4p5o B 3.11 BS02 ZN B 2 C75 H77 C94 D97 C46 H48 C65 D68 6.3.2.- P62877 24949976 EVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQ 4p5o B 3.11 BS03 ZN B 3 C53 C56 C68 H82 C31 C34 C39 H53 6.3.2.- P62877 24949976 EVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQ 4p7n A 1.89 BS01 GCS A 1 Y432 D466 W613 Y645 Y127 D161 W308 Y340 3.5.1.- P75906 GSHMEKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWYP 4p7n A 1.89 BS02 GCS A 2 D472 Y473 D167 Y168 3.5.1.- P75906 GSHMEKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWYP 4p7n A 1.89 BS03 GCS A 3 F540 L542 F553 L575 E576 F235 L237 F248 L270 E271 3.5.1.- P75906 GSHMEKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWYP 4p7q A 1.65 BS01 NAG A 1 G361 D362 G363 P429 E430 Q431 Y432 G52 D53 G54 P120 E121 Q122 Y123 3.5.1.- P75906 EKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWY 4p7q A 1.65 BS02 NAG A 2 D472 Y473 W552 D163 Y164 W243 3.5.1.- P75906 EKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWY 4p7q A 1.65 BS03 NAG A 3 I427 P429 H433 I118 P120 H124 3.5.1.- P75906 EKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWY 4p7q A 1.65 BS04 NAG A 4 D320 D322 Y323 D358 W613 Y645 P646 D11 D13 Y14 D49 W304 Y336 P337 3.5.1.- P75906 EKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWY 4p7r A 1.80 BS01 NAG A 1 L542 W552 F553 E576 L233 W243 F244 E267 3.5.1.- P75906 EKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWY 4pdw A 3.00 BS01 2XK A 1 I104 L106 S126 Y128 Y152 F186 V191 Y197 M221 M224 I89 L91 S111 Y113 Y137 F171 V176 Y182 M206 M209 3.4.22.29,3.6.1.15,3.4.22.28,2.7.7.48 P03303 24948704 QTVASISSGPKHTQKVPILTANETGATMPVLPSDSIETRTTYMHFNGSETDVECFLGRAACVHVTEIQNKDATGIDNHREAKLFNDWKINLSSLVQLRKKLELFTYVRFDSEYTILATASQPDSANYSSNLVVQAMYVPPGAPNPKEWDDYTWQSASNPSVFFKVGDTSRFSVPYVGLASAYNCFYDGYSHDDAETQYGITVLNHMGSMAFRIVNEHDEHKTLVKIRVYHRAKHVEAWIPRAPRALPYTSIGRTNYPKNTEPVIKKRKGDIKSY 4pfq A 2.10 BS01 MG A 1 E126 D127 E98 D99 2.4.2.8 C7MC15 PHPDVDRVLLDEQQIRDRLAELGEQIAADYAEEPPVLVGVLRGAVMVMADLARQIDLKVEMDWMAVSSYGSGTKSSGVVRILKDLSGDITDRNVLIVEDIIDSGLTLKWLLSNLRSRGPKSVEVAALLRKPDAARVDIDVKYIGFDIPSEFVIGYGLDYAENYRNLPYVGVLSRSVY 4pgh A 2.80 BS01 SAM A 1 G206 D229 L230 D249 M250 F251 K263 I265 G198 D221 L222 D241 M242 F243 K255 I257 2.1.1.68 C5YH12 24948836 AAVADEEACMYAMQLASSSILPMTLKNALELGLLEVLQKDAGKALAAEEVVARLPVAPTNPAAADMVDRMLRLLASYDVVKCQMEDKDGKYERRYSAAPVGKWLTPNEDGVSMAALALMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNRVFNEGMKNHSVIITKKLLEFYTGFDESVSTLVDVGGGIGATLHAITSHHSHIRGVNFDLPHVISEAPPFPGVQHVGGDMFKSVPAGDAILMKWILHDWSDAHCATLLKNCYDALPEKGGKVIVVECVLPVTTDAVPKAQGVFHVDMIMLAHNPGGRERYEREFRDLAKAAGFSGFKATYIYANAWAIEFIK 4pgh B 2.80 BS01 SAM B 1 G206 D229 L230 G248 D249 M250 F251 K263 I265 D268 G201 D224 L225 G243 D244 M245 F246 K258 I260 D263 2.1.1.68 C5YH12 24948836 EDVAAVADEEACMYAMQLASSSILPMTLKNALELGLLEVLQKDAGKALAAEEVVARLPVAPTNPAAADMVDRMLRLLASYDVVKCQMEDKDGKYERRYSAAPVGKWLTPNEDGVSMAALALMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNRVFNEGMKNHSVIITKKLLEFYTGFDESVSTLVDVGGGIGATLHAITSHHSHIRGVNFDLPHVISEAPPFPGVQHVGGDMFKSVPAGDAILMKWILHDWSDAHCATLLKNCYDALPEKGGKVIVVECVLPVTTDAVPKAQGVFHVDMIMLAHNPGGRERYEREFRDLAKAAGFSGFKATYIYANAWAIEFIK 4pgh D 2.80 BS01 SAM D 1 G206 D229 L230 D249 M250 K263 I265 G202 D225 L226 D245 M246 K259 I261 2.1.1.68 C5YH12 24948836 AEDVAAVADEEACMYAMQLASSSILPMTLKNALELGLLEVLQKDAGKALAAEEVVARLPVAPTNPAAADMVDRMLRLLASYDVVKCQMEDKDGKYERRYSAAPVGKWLTPNEDGVSMAALALMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNRVFNEGMKNHSVIITKKLLEFYTGFDESVSTLVDVGGGIGATLHAITSHHSHIRGVNFDLPHVISEAPPFPGVQHVGGDMFKSVPAGDAILMKWILHDWSDAHCATLLKNCYDALPEKGGKVIVVECVLPVTTDAVPKAQGVFHVDMIMLAHNPGGRERYEREFRDLAKAAGFSGFKATYIYANAWAIEFIK 4pib A 2.00 BS01 CA A 1 S131 N132 S115 N116 Q2SVW5 SHITINVMTVIDVAAIIDELKAQEKKLGQTPDTATSIGHKYIYMSSDDPRGWSVDPGNITLNAHVGDTLSFFCASTSDNSEYAAFIYRLTGGDPHLDPSHVEVIKLQNAAQPTPSNGYPFTTAPVAFSSCDAKVAQQGQAKNFYVWAALFTLDDSGEKQVLAGYVKWDPTVNVA 4pib B 2.00 BS01 CA B 1 D113 P114 D99 P100 Q2SVW5 SHITINVMTVIDVAAIIDELKAQEKKLGQTPDTATSIGHKYIYMSSDDPRGWSVGNDPGNITLNAHVGDTLSFFCASTSDNSEYAAFIYRLTGGDPHLDPSHVEVIKLQNAAQPTPSNGYPFTTAPVAFSSCDAKVAQQGQAKNFYVWAALFTLDDSGEKQVLAGYVKWDPTVNVA 4pj5 A 2.00 BS01 30W A 1 Y7 R9 K43 Y62 W69 R94 I96 Y152 W156 Y7 R9 K43 Y62 W69 R94 I96 Y152 W156 Q95460 RTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELLYSCHVEHSGVHMVLQV 4pje A 1.95 BS01 30W A 1 Y7 R9 K43 Y62 L66 W69 R94 I96 Y152 W156 Y7 R9 K41 Y60 L64 W67 R92 I94 Y150 W154 Q95460 RTHSLRYFRLGVSDPIVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELLYSCHVEHSGVHMVLQV 4pkf B 2.00 BS01 SF4 B 1 P16 C26 C29 W31 Q32 C44 A46 C67 R69 H70 P4 C14 C17 W19 Q20 C32 A34 C55 R57 H58 4.1.99.11 O68396 QNQPHTEVGTARPCRSCKWQTPDPTDPHRGQCTANRHAMGGVWKRWLRDVENTTCSRHEEGKLSFRDHV 4plc A 1.50 BS01 PYR A 1 W97 R99 N131 R162 H186 G229 W93 R95 N127 R158 H182 G225 MTKRKKISLIGSGMIGGTMAYLCAQKELGDVVLFDVVKNMPQGKALDLSHSSSIADTNVKVTGTNSYEDIKGSDVVIITAGLTKAPGKSDKEWSRDDLLPFNAKIMREVGENIKKYCPNAFVIVITNPLDVMVKVLHEHSGLPKNKVCGMAGVLDSSRFRHFIAEKLNVSPRDVQAMVIGAHGDKMVPLTRYVTVNGIPLQEFIKKGRITQEEIDEIVERTKNAGGEIVNLLGQGSAYFAPAASAIEMAEAYLKDKKRVLVCSCYLEGQYGHKDMFVGVPAVIGGNGVEKVIELELTPEEKELFDKSVEEVRKLQKAIKALGLE 4plc A 1.50 BS02 NAI A 1 I14 G17 M18 I19 F38 D39 V40 V41 M44 Y71 T83 A84 G85 L86 T87 L102 N106 I109 E112 I129 T130 N131 M154 L158 H186 A241 P245 I10 G13 M14 I15 F34 D35 V36 V37 M40 Y67 T79 A80 G81 L82 T83 L98 N102 I105 E108 I125 T126 N127 M150 L154 H182 A237 P241 MTKRKKISLIGSGMIGGTMAYLCAQKELGDVVLFDVVKNMPQGKALDLSHSSSIADTNVKVTGTNSYEDIKGSDVVIITAGLTKAPGKSDKEWSRDDLLPFNAKIMREVGENIKKYCPNAFVIVITNPLDVMVKVLHEHSGLPKNKVCGMAGVLDSSRFRHFIAEKLNVSPRDVQAMVIGAHGDKMVPLTRYVTVNGIPLQEFIKKGRITQEEIDEIVERTKNAGGEIVNLLGQGSAYFAPAASAIEMAEAYLKDKKRVLVCSCYLEGQYGHKDMFVGVPAVIGGNGVEKVIELELTPEEKELFDKSVEEVRKLQKAIKALGLE 4plc B 1.50 BS01 PYR B 1 W97 R99 N131 R162 H186 S240 W93 R95 N127 R158 H182 S236 MTKRKKISLIGSGMIGGTMAYLCAQKELGDVVLFDVVKNMPQGKALDLSHSSSIADTNVKVTGTNSYEDIKGSDVVIITAGLTKAPGKSDKEWSRDDLLPFNAKIMREVGENIKKYCPNAFVIVITNPLDVMVKVLHEHSGLPKNKVCGMAGVLDSSRFRHFIAEKLNVSPRDVQAMVIGAHGDKMVPLTRYVTVNGIPLQEFIKKGRITQEEIDEIVERTKNAGGEIVNLLGQGSAYFAPAASAIEMAEAYLKDKKRVLVCSCYLEGQYGHKDMFVGVPAVIGGNGVEKVIELELTPEEKELFDKSVEEVRKLQKAIKALGLE 4plf B 1.35 BS02 PYR B 1 W97 R99 N131 R162 H186 G229 S240 W93 R95 N127 R158 H182 G225 S236 MTKRKKISLIGSGMIGGTMAYLCAQKELGDVVLFDVVKNMPQGKALDLSHSSSIADTNVKVTGTNSYEDIKGSDVVIITAGLTKAPGKSDKEWSRDDLLPFNAKIMREVGENIKKYCPNAFVIVITNPLDVMVKVLHEHSGLPKNKVCGMAGVLDSSRFRHFIAEKLNVSPRDVQAMVIGAHGDKMVPLTRYVTVNGIPLQEFIKKGRITQEEIDEIVERTKNAGGEIVNLLGQGSAYFAPAASAIEMAEAYLKDKKRVLVCSCYLEGQYGHKDMFVGVPAVIGGNGVEKVIELELTPEEKELFDKSVEEVRKLQKAIKALGLEHHHHHH 4plh A 1.90 BS01 NAI A 1 G13 N14 I15 F34 D35 I36 V37 M40 T79 A80 G81 I100 V120 N122 M145 L149 H177 P236 G11 N12 I13 F32 D33 I34 V35 M38 T77 A78 G79 I94 V114 N116 M139 L143 H171 P230 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGIPRSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKKLNAL 4plh B 1.90 BS01 NAI B 1 G13 N14 I15 F34 D35 I36 V37 M40 T79 A80 G81 I82 P83 I100 V120 N122 M145 L149 H177 A232 P236 G11 N12 I13 F32 D33 I34 V35 M38 T77 A78 G79 I80 P81 I98 V118 N120 M143 L147 H175 A230 P234 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGIPRKPGMSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKK 4plt B 1.60 BS01 NAI B 1 G13 N14 I15 F34 D35 I36 V37 M40 Y67 T79 A80 G81 I82 P83 I105 V125 T126 N127 L129 M150 L154 H182 A237 P241 G12 N13 I14 F33 D34 I35 V36 M39 Y66 T78 A79 G80 I81 P82 I104 V124 T125 N126 L128 M149 L153 H181 A236 P240 TQRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGIPRKPGKSDKEWSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKK 4plt A 1.60 BS01 NAI A 1 G13 N14 I15 F34 D35 I36 V37 M40 Y67 T79 A80 G81 I82 P83 L98 I105 V125 T126 N127 M150 L154 H182 A237 P241 G12 N13 I14 F33 D34 I35 V36 M39 Y66 T78 A79 G80 I81 P82 L97 I104 V124 T125 N126 M149 L153 H181 A236 P240 TQRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGIPRKPGKSDKEWSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKK 4plw A 1.85 BS01 NAI A 1 G13 N14 I15 D35 I36 V37 M40 T79 A80 G81 P83 I100 V120 T121 N122 L124 M145 L149 H177 A232 P236 G11 N12 I13 D33 I34 V35 M38 T77 A78 G79 P81 I98 V118 T119 N120 L122 M143 L147 H175 A230 P234 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGIPRKPGMSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKKLNAL 4ply B 1.90 BS02 PYR B 1 W93 R95 N127 R158 H182 G225 S236 W91 R93 N125 R156 H180 G223 S234 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGIPRKPGKSDKEWSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKK 4ply A 1.90 BS02 PYR A 1 W93 R95 N127 R158 H182 G225 W91 R93 N125 R156 H180 G223 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGIPRKPGKSDKEWSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKK 4ply C 1.90 BS01 NAI C 1 G13 N14 I15 F34 D35 I36 V37 T79 A80 I105 V125 T126 N127 L129 M150 L154 H182 P241 G11 N12 I13 F32 D33 I34 V35 T77 A78 I87 V107 T108 N109 L111 M132 L136 H164 P223 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKKL 4ply D 1.90 BS02 PYR D 1 N127 R158 H182 N110 R141 H165 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKK 4ply F 1.90 BS02 PYR F 1 W93 R95 N127 L154 R158 H182 S236 W91 R93 N125 L152 R156 H180 S234 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGIPRKPGKSDKEWSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKK 4ply E 1.90 BS02 PYR E 1 W93 R95 N127 L154 R158 H182 W91 R93 N125 L152 R156 H180 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGIPRKPGKSDKEWSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKK 4ply H 1.90 BS02 PYR H 1 N127 R158 H182 G225 N110 R141 H165 G208 QRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVMVYVLHKYSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAESYLKDKKRILPCSAYLEGQYGVKDLFVGVPVIIGKNGVEKIIELELTEEEQEMFDKSVESVRELVETVKK 4plz A 1.05 BS01 NAI A 1 G10 G12 M13 I14 F33 D34 I35 V36 Y66 T78 A79 G80 V124 T125 N126 V128 L149 L153 H181 P238 G8 G10 M11 I12 F31 D32 I33 V34 Y64 T76 A77 G78 V110 T111 N112 V114 L135 L139 H167 P224 1.1.1.27 Q71T02 KAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALAH 4pqn A 1.71 BS01 2W6 A 1 I369 L379 A389 V419 F435 E436 F437 M438 E439 H440 G441 L489 S499 D500 I13 L21 A31 V61 F77 E78 F79 M80 E81 H82 G83 L131 S141 D142 2.7.10.2 Q08881 24918870 VIDPSELTFVQEIGSGGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEASVIHRDLAARNCLVGENQVIKVSDFGFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAAI 4prj A 2.80 BS01 2VU A 1 R137 L139 V147 A160 K162 L194 L210 E211 Y212 A213 P214 G216 R220 L263 A273 D274 R13 L15 V20 A33 K35 L67 L83 E84 Y85 A86 P87 G89 R93 L136 A146 D147 2.7.11.1 O14965 24918870 KRQWALEDFEIGRPLGKGNVYLAREKNSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDSTRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKKVIHRDIKPENLLLGSAGELKIADFGWSVCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQDTYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSS 4psq B 2.40 BS01 2WL B 1 L35 F36 L37 M73 V74 M88 Y90 G100 R121 F135 L35 F36 L37 M73 V74 M88 Y90 G100 R121 F135 P02753 24835984 ERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCD 4pz5 A 1.96 BS01 III B 1 R83 K85 R99 R101 I102 C104 T105 I106 A107 R21 K23 R37 R39 I40 C42 T43 I44 A45 P02751 EETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPI 4q0a C 1.90 BS01 III D 1 I270 K274 R280 Q287 I288 L291 K292 P442 L443 E446 I56 K60 R66 Q73 I74 L77 K78 P228 L229 E232 Q9PTN2 24818857 MLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSWSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEVS 4q0a C 1.90 BS02 4OA C 1 Y175 L261 V262 I296 S303 S306 W314 C316 Y323 V328 H333 L337 L338 Y21 L47 V48 I82 S89 S92 W100 C102 Y109 V114 H119 L123 L124 Q9PTN2 24818857 MLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSWSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEVS 4q0a C 1.90 BS03 4OA C 2 D181 R184 F185 S263 Q267 D27 R30 F31 S49 Q53 Q9PTN2 24818857 MLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSWSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEVS 4q2e A 3.40 BS01 MG A 1 D164 D239 D269 G270 D136 D211 D241 G242 2.7.7.41 Q9X1B7 ITASVVAPFVVLCFVSYESLIGLVSAILILAGYELITLEMKERDARFFYVILLALYPVLYGLVFEEPTQPLSILFITGVVFSLITDKDPSQVFKTVAAFSIALIYVTFFLSFFLPIYRDFGAANALLVLTSTWVFDSFAYFTGLKFGRTRISPRYSPRKSLEGVIGGFLGVVIYTFLYRLVVNDLLSVNVICFRTFLPFAATVAIMDTFGDIFECALKRHYGVKDSGKTLPGHGGMLDRIDGLLFVAPVSYIVFKILEGVVR 4q2g A 3.40 BS01 MG A 1 D239 D266 D269 D210 D237 D240 2.7.7.41 Q9X1B7 TASVVAPFVVLCFVSYESLIGLVSAILILAGYELITLEMKERDARFFYVILLALYPVLYGLVFEEPTQPLSILFITGVVFSLITDKDPSQVFKTVAAFSIALIYVTFFLSFFLPIYRDFGAANALLVLTSTWVFDSFAYFTGLKFGRTRISPRYSPRKSLEGVIGGFLGVVIYTFLYRLVVNDLLSVNVICFRTFLPFAATVAIMDTFGDIFESALKRHYGVKDSGKTLPGHGGMLDRIDGLLFVAPVCYIVFKILEGVVR 4q5h A 2.00 BS01 ANP A 1 G36 T38 A39 I41 L51 K53 F76 M98 L99 R100 V101 P105 G142 N143 L145 I156 D157 G12 T14 A15 I17 L27 K29 F52 M74 L75 R76 V77 P81 G118 N119 L121 I132 D133 2.7.-.- Q3YTH2 24856362 AEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESESLFPIDFRNIYAEYYAATKKDKEIIDRRLQMRTNDFYSLLNR 4q6b A 1.67 BS01 LEU A 1 R79 N80 S81 A102 S103 T104 N228 Y282 R74 N75 S76 A97 S98 T99 N223 Y266 B8FZ96 EEIFIGVAWPFASLDDLFAEGLELAVQEINEQGGVQGRKLSLVKADDEAELEKGLAIAQAFADNAGIQAVIGHRNSFISIPAASIYDQAGLVMLSPASTSPDLTDHGYIHVFRNIPSDQEIARQLAIYLAEQGHERMVIYYTDDSYGNGLANAFEDYARAQGITIVDRFNYYGNLKDLERLYDKWQAFGMDGIFIAKTATGGGTEFLVDAKSVGIEVPLIAGNSWDAMTAEGLLVGSFFNPQRPDSRTQDFVEAFRREYGQPPTSYAAAGYDAVILLAEALEKSDLTHPATLAQGLRDLGPWEGVMGMHRFDGRGDDIGDLVVLKKMKDGRFEYL 4q6b A 1.67 BS02 CA A 1 D172 R173 D167 R168 B8FZ96 EEIFIGVAWPFASLDDLFAEGLELAVQEINEQGGVQGRKLSLVKADDEAELEKGLAIAQAFADNAGIQAVIGHRNSFISIPAASIYDQAGLVMLSPASTSPDLTDHGYIHVFRNIPSDQEIARQLAIYLAEQGHERMVIYYTDDSYGNGLANAFEDYARAQGITIVDRFNYYGNLKDLERLYDKWQAFGMDGIFIAKTATGGGTEFLVDAKSVGIEVPLIAGNSWDAMTAEGLLVGSFFNPQRPDSRTQDFVEAFRREYGQPPTSYAAAGYDAVILLAEALEKSDLTHPATLAQGLRDLGPWEGVMGMHRFDGRGDDIGDLVVLKKMKDGRFEYL 4q6w A 1.84 BS01 3HB A 1 F44 G106 S107 I128 A129 Q130 Y183 L236 G261 I324 F19 G81 S82 I103 A104 Q105 Y158 L211 G236 I299 Q7VS30 ADTIKIGMTSALTGPYNEFGEGNRRAVELAVEQWNAKGGINGKKIEIAMLLDDQLNPDRAVQNIRAILDNKDIVGIIGPAGSGPMLAVIDMVQADGRPYMNPIAQTPVVTYPGEKTGEKPRPNVFSFALQNDIEAVAMGEYLAKKFKRVGIIHESTAYGVTGVDYLAASIAKNGGAKPVATDSYNQGAQDMTAQVARMKRANVDAIAAIGLGKDLAVLRRTMARLNVNVPLAASNGALGQPYQEGAGELTLGTLGTMIGAFGNPMRAPAADFAKAYKAKYGTDRWWGNDPENPQLFMAISVSNGYDAANILFEGIRLANSTDPKAVIAAIESIKDYQGVNTAYTFSKERHHGIETDGVKVFEYVKKGDKIRLEPIA 4q8e A 1.55 BS01 NUC T 1 Q38 Y39 W42 G46 I47 I48 S62 W64 K86 R93 K293 K311 R313 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351 Q41 Y42 W45 G49 I50 I51 S65 W67 K89 R96 K291 K309 R311 P314 K315 T316 G318 C319 S320 K321 N322 P324 R349 2.7.7.7 Q9Y253 24927576 GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSAS 4q8f A 2.80 BS01 NUC T 1 Q38 Y39 W42 G46 I48 W64 K86 K293 K311 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 R351 Q38 Y39 W42 G46 I48 W64 K86 K288 K306 P311 K312 T313 I314 G315 C316 S317 K318 N319 P321 R345 2.7.7.7 Q9Y253 24927576 MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSAS 4q8f A 2.80 BS02 NUC P 1 R61 S113 D115 E116 K224 R256 S257 L258 G259 G260 K261 L262 R382 R383 C384 R61 S113 D115 E116 K219 R251 S252 L253 G254 G255 K256 L257 R375 R376 C377 2.7.7.7 Q9Y253 24927576 MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSAS 4q9s A 2.07 BS01 30G A 1 I428 E430 A452 V484 M499 E500 C502 G505 E506 L553 I15 E17 A37 V69 M84 E85 C87 G90 E91 L138 2.7.10.2 Q05397 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ 4q9z A 2.60 BS01 PZW A 1 L386 G387 F391 V394 A407 M458 E459 L461 D508 N509 L511 D522 F664 L12 G13 F17 V20 A33 M84 E85 L87 D134 N135 L137 D148 F290 2.7.11.13 Q04759 LKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLISH 4q9z B 2.60 BS01 PZW B 1 L386 F391 V394 A407 M458 E459 L461 D508 L511 D522 F659 L13 F18 V21 A34 M85 E86 L88 D135 L138 D149 F286 2.7.11.13 Q04759 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKNMFRNFSFMNPGMERL 4qec A 1.90 BS01 NAP A 1 G10 K13 G14 I15 S34 R35 K39 L59 D60 V61 N87 A88 G89 I138 S139 S140 Y153 K157 P183 G184 I186 T188 G9 K12 G13 I14 S33 R34 K38 L58 D59 V60 N86 A87 G88 I137 S138 S139 Y152 K156 P182 G183 I185 T187 I6ZQW6 24866416 MKKNVLITGGFKGIGKQVALEFLKNDYHVCITSRYFEKEKRIPHLFSSYEENISFYQLDVTDEEQVNEIINKIVKKFGRLDVLVNNAGISLSDGLLTETKTTDFNKMINTNILGTYFCMKYALKHMQKVSCGAIVNISSITGLSGFPYSILYGSTKHAVIGLTKGAAVEFADKGIKINAVAPGIIKTETLQKEIDSGEFSEDSISSIHPMQKLGTTLDVAKGIYFLANEDNNFITGHVLSIDGGYLSQ 4qf3 A 1.60 BS01 ZN A 1 C1934 C1937 H1957 C1960 C8 C11 H31 C34 Q9UIF8 MSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKAS 4qf3 A 1.60 BS02 ZN A 2 C1949 C1952 C1975 C1978 C23 C26 C49 C52 Q9UIF8 MSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKAS 4qi9 A 2.30 BS01 MTX A 1 I6 A7 D28 F32 K33 S50 I51 R53 L55 R58 M95 Y101 T114 I6 A7 D19 F23 K24 S41 I42 R44 L46 R49 M86 Y92 T105 1.5.1.3 Q7CG83 MIISLIAALAADRVILPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVGGDTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERRGENLYFQ 4qi9 B 2.30 BS01 MTX B 1 I6 A7 A8 D28 F32 K33 S50 I51 R53 L55 R58 M95 Y101 T114 I6 A7 A8 D20 F24 K25 S42 I43 R45 L47 R50 M87 Y93 T106 1.5.1.3 Q7CG83 MIISLIAALAADRVIHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVGGDTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERRGENLYFQ 4qjb A 2.05 BS01 MG A 1 D27 D29 D238 D27 D29 D238 Q8IJ74 MHEIVDKNGKKVQKNNLNDEIKIIFTDLDGTLLNSENKVSEQNLESLIRAQEKGIKVVIATGRSIFSVENVIGEHVKKNRISLLPGIYMNGCVTFDEKGSRVIDRIMNNDLKMEIHEFSKQINISKYAIWFCLEKTYCFEINDCIREYMEVEALNPDVIEDNMLEGLTVYKVLFSLPENILENTLKLCREKFSHRINVANTFQSYVELFHQHTNKFEGVKEICKYYNISLNNALAMGDGENDIEMLSGLTHSVGVHNASEKVKNSAAYVGPSNNEHAISHVLKTFCDI 4qji A 2.65 BS01 CTP A 1 M275 A277 V279 D281 D308 D309 V310 L311 F332 K350 R353 K354 M92 A94 V96 D98 D121 D122 V123 L124 F145 K163 R166 K167 4.1.1.36 A0QWT2 HHDMAGVKALVTAGGTREPLDPVRFIGNRSSGKQGYAVARVLAQRGADVTLIAGNTAGLIDPAGVEMVHIGSATQLRDAVSKHAPDANVLVMAAAVADFRPAHVAAAKIKEPSSIDLVRNDDVLAGAVRARADGQLPNMRAIVGFAAETGDANGDVLFHARAKLERKGCDLLVVNDGWLLSADGTESALEHGSKTLMATRIVDSIAAFLKSQ 4ql5 B 2.02 BS01 ZN B 1 E25 G29 E19 G23 P65121 IEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRFK 4qn2 A 2.60 BS01 NAD A 1 I153 T154 P155 W156 N157 K180 S182 E183 G213 G217 D218 F231 T232 G233 S234 T237 H240 I241 E255 L256 G257 C289 E390 F392 L418 W456 I159 T160 P161 W162 N163 K186 S188 E189 G219 G223 D224 F237 T238 G239 S240 T243 H246 I247 E261 L262 G263 C295 E396 F398 L424 W462 1.2.1.8 Q5HCU0 NLYFQGMELLKHLSQRQYIDGEWVESANKNTRDIINPYNQEVIFTVSEGTKEDAERAILAARRAFESGEWSQETAETRGKKVRAIADKIKEHREALARLETLDTGKTLEESYADMDDIHNVFMYFAGLADKDGGEMIDSPIPDTESKIVKEPVGVVTQITPWNYPLLQASWKIAPALATGCSLVMKPSEITPLTTIRVFELMEEVGFPKGTINLILGAGSEVGDVMSGHKEVDLVSFTGSIETGKHIMKNAANNVTNIALELGGKNPNIIFDDADFELAVDQALNGGYFHAGQVCSAGSRILVQNSIKDKFEQALIDRVKKIKLGNGFDADTEMGPVISTEHRNKIESYMDVAKAEGATIAVGGKRPDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFETEQEAIQLANDSIYGLAGAVFSKDIGKAQRVANKLKLGTVWINDFHPYFAQAPWGGYKQSGIGRELGKEGLEEYLVSKHILTNTNPQLVNWFSK 4tlg A 1.77 BS01 11A A 1 P108 H162 Y171 P106 H160 Y169 Q9UDX3 SRVGDLSPQQQEALARFRENLQDLLPILPNADDYFLLRWLRARNFDLQKSEDMLRRHMEFRKQQDLDNIVTWQPPEVIQLYDSGGLCGYDYEGCPVYFNIIGSLDPKGLLLSASKQDMIRKRIKVCELLLHECELQTQKLGRKIEMALMVFDMEGLSLKHLWKPAVEVYQQFFSILEANYPETLKNLIVIRAPKLFPVAFNLVKSFMSEETRRKIVILGDNWKQELTKFISPDQLPVEFGGTMTDPDGNPKCLTKINYGGEVPKSYYLCEQVRLQYEHTRSVGRGSSLQVENEILFPGCVLRWQFASDGGDIGFGVFLKTKMGEQQSAREMTEVLPSQRYNAHMVPEDGSLTCLQAGVYVLRFDNTYSRMHAKKLSYTVEVLLPDKASEETLQSMR 4tlg B 1.77 BS01 11A B 1 P108 H162 Y171 V191 P100 H154 Y163 V183 Q9UDX3 DLSPQQQEALARFRENLQDLLPILADDYFLLRWLRARNFDLQKSEDMLRRHMEFRKQQDLDNIVTWQPPEVIQLYDSGGLCGYDYEGCPVYFNIIGSLDPKGLLLSASKQDMIRKRIKVCELLLHECELQTQKLGRKIEMALMVFDMEGLSLKHLWKPAVEVYQQFFSILEANYPETLKNLIVIRAPKLFPVAFNLVKSFMSEETRRKIVILGDNWKQELTKFISPDQLPVEFGGTMTDPDGNPKCLTKINYGGEVPKSYYLCEQVRLQYEHTRSVGRGSSLQVENEILFPGCVLRWQFASDGGDIGFGVFLKTKMGEQQSAREMTEVLPSQRYNAHMVPEDGSLTCLQAGVYVLRFDNTYSRMAKKLSYTVEVLLPDKASEETLQSM 4tll A 3.59 BS01 1AC A 1 F482 P514 L515 T516 R521 S678 W721 D722 F748 F460 P492 L493 T494 R499 S635 W678 D679 F705 DPKIVNIGAVLSTKKHEQIFREAVNQANFFHFTRKIQLNATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFDGSYIIQNDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETIPGRPTVPQCCYGFCVDLLIKLAREMDFTYEVHLVADGKFGTQERVNNSNAAAWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFLSSAMWFSWRVLLSFSARILGMVWAGFAMIIVASYTANLAAFLVLRRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEELDKTWVRYQECDAGGIVAGIFLIFIEIAYKSRA 4tll A 3.59 BS02 QEM B 1 Y109 T110 F113 K131 S132 I133 L135 Y87 T88 F91 K109 S110 I111 L113 DPKIVNIGAVLSTKKHEQIFREAVNQANFFHFTRKIQLNATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFDGSYIIQNDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETIPGRPTVPQCCYGFCVDLLIKLAREMDFTYEVHLVADGKFGTQERVNNSNAAAWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFLSSAMWFSWRVLLSFSARILGMVWAGFAMIIVASYTANLAAFLVLRRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEELDKTWVRYQECDAGGIVAGIFLIFIEIAYKSRA 4tll B 3.59 BS01 QEM B 1 Q105 I106 F109 T169 Y170 F171 P172 E231 Q80 I81 F84 T144 Y145 F146 P147 E206 KHPNMDIAVILVGTTEEVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDIDSKIQNQLCKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDTVPDEFPTGLISVSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKSSCNNIQESRVYEAHMLKRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNQERKWERVGKYKDRSLKMWPVFHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIRPEGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKINGVWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVKAIWLLWGLVFNNTSKIMVSVWAFFAVIFLASYTANLAAFMIQRRYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQDALLSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNFYMLAAAMALSLITFIMEHLFY 4tll C 3.59 BS01 QEM D 1 Y109 T110 F113 K131 S132 I133 L135 Y87 T88 F91 K109 S110 I111 L113 DPKIVNIGAVLSTKKHEQIFREAVNQANFFHFTRKIQLNATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFDGSYIIQNDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDPTVPQCCYGFCVDLLIKLAREMDFTYEVHLVADGKFGTQERVAAWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDSARILGMVWAGFAMIIVASYTANLAAFLVLRRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEELDKTWVRYQECDS 4tll D 3.59 BS01 QEM D 1 A102 Q105 I106 F109 F171 E231 A69 Q72 I73 F76 F138 E198 HPNMDIAVILVGTTEEVAIKDHHLPVTPRVELVTMQESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDIDSKIQNQLCKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDTVPDEFPTGLISVSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSSKSSCNNIQESRVYEAHMLKRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNQERKWERVGKYKDRSLKMWPVFDLYPNEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIRPENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKINGVWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNSAFLEPFSADVWVMMFVMLLIVSAVAVFVSFTIGKAIWLLWGLVFNNSKIMVSVWAFFAVIFLASYTANLAAFMIQRRYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQDALLSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFYK 4tll D 3.59 BS02 JEG D 1 H479 T507 V669 G672 S673 T674 Y714 D715 H437 T465 V599 G602 S603 T604 Y644 D645 HPNMDIAVILVGTTEEVAIKDHHLPVTPRVELVTMQESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDIDSKIQNQLCKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDTVPDEFPTGLISVSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSSKSSCNNIQESRVYEAHMLKRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNQERKWERVGKYKDRSLKMWPVFDLYPNEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIRPENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKINGVWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNSAFLEPFSADVWVMMFVMLLIVSAVAVFVSFTIGKAIWLLWGLVFNNSKIMVSVWAFFAVIFLASYTANLAAFMIQRRYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQDALLSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFYK 4tlm A 3.77 BS01 1AC A 1 F482 L515 T516 R521 S678 D722 F460 L493 T494 R499 S641 D685 DPKIVNIGAVLSTKKHEQIFREAVNQANFFHFTRKIQLNATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFDGSYIIQNDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETIPGRPTVPQCCYGFCVDLLIKLAREMDFTYEVHLVADGKFGTQERVNNSNAAAWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSLTLSSAMWFSWRVLLNSGLGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLRRITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEELDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKSRAEA 4tlm A 3.77 BS02 QEM A 1 Y109 F113 S132 I133 L135 Y87 F91 S110 I111 L113 DPKIVNIGAVLSTKKHEQIFREAVNQANFFHFTRKIQLNATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFDGSYIIQNDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETIPGRPTVPQCCYGFCVDLLIKLAREMDFTYEVHLVADGKFGTQERVNNSNAAAWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSLTLSSAMWFSWRVLLNSGLGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLRRITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEELDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKSRAEA 4tlm B 3.77 BS01 QEM A 1 A102 I106 F109 Y170 F171 P172 E231 A77 I81 F84 Y145 F146 P147 E206 KHPNMDIAVILVGTTEEVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDIDSKIQNQLCKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDTVPDEFPTGLISVSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKSSCNNIQESRVYEAHMLKRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNQERKWERVGKYKDRSLKMWPVFDLYSEEHKDEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKINGVWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRAFLEPFSADVWVMMFVMLLIVSAVAVFVFEIGKAIWLLWGLVFNNSLPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQDALLSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKIDNMAGVFYMLAAAMALSLITFIMEHLFYKS 4tlm C 3.77 BS01 QEM C 1 Y109 T110 K131 S132 I133 H134 L135 Y87 T88 K109 S110 I111 H112 L113 DPKIVNIGAVLSTKKHEQIFREAVNQANFFHFTRKIQLNATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFDGSYIIQNDRKIIWPGGETERYQMSTRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETIPGRPTVPQCCYGFCVDLLIKLAREMDFTYEVHLVADGKLLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSTLSSAMWFSWRVLLNSGLGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLRRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEELDKTWVRYTLTFENMAGVFMLVAGGIVAGIFLIFIEIA 4tlm D 3.77 BS01 QEM C 1 Q105 I106 F109 Y170 F171 Q76 I77 F80 Y141 F142 MDIAVILVGTTEEVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDIDSKIQNQLCKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDTVPDEFPTGLISVSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKSSCNNIQESRVYEAHMLKRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNQERKWERVGKYKDRSLKMWEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKINGVWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEFTIGKAIWLLWGLVFNNSLPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQRRYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQDALLSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFYKS 4tlm D 3.77 BS02 JEG D 1 H479 S505 L506 T507 S673 T674 H424 S450 L451 T452 S603 T604 MDIAVILVGTTEEVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDIDSKIQNQLCKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDTVPDEFPTGLISVSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKSSCNNIQESRVYEAHMLKRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNQERKWERVGKYKDRSLKMWEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKINGVWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEFTIGKAIWLLWGLVFNNSLPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQRRYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQDALLSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFYKS