3j5l 0 6.60 BS01 NUC A 1 A1 V2 Q3 Q4 N5 K6 P7 T8 R9 S10 K11 R12 G13 M14 R15 R16 S17 H18 A20 T25 S26 R39 H40 Y48 R49 K56 A1 V2 Q3 Q4 N5 K6 P7 T8 R9 S10 K11 R12 G13 M14 R15 R16 S17 H18 A20 T25 S26 R39 H40 Y48 R49 K56 P0A7N4 AVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRHHITADGYYRGRKVIAK 3j5l 1 6.60 BS01 NUC A 1 G3 I4 R5 K7 F19 Y20 T21 T22 N25 K29 L35 K36 K37 F38 P40 H45 G1 I2 R3 K5 F17 Y18 T19 T20 N23 K27 L33 K34 K35 F36 P38 H43 P0A7N9 GIREKIKLVSSAGTGHFYTTTKNKRTKPEKLELKKFDPVVRQHVIYKEAK 3j5l 2 6.60 BS01 NUC A 1 M1 K2 R3 T4 F5 Q6 P7 S8 V9 L10 K11 R12 N13 R14 S15 H16 G17 F18 R19 R21 M22 K25 N26 Q29 V30 R33 R34 R35 K37 G38 R39 A40 R41 S45 M1 K2 R3 T4 F5 Q6 P7 S8 V9 L10 K11 R12 N13 R14 S15 H16 G17 F18 R19 R21 M22 K25 N26 Q29 V30 R33 R34 R35 K37 G38 R39 A40 R41 S45 P0A7P5 MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKGRARLTVSK 3j5l 3 6.60 BS01 NUC A 1 P1 K2 I3 K4 T5 V6 R7 K11 R12 T16 G17 K18 K22 H23 H25 A26 N27 R29 H30 I31 L32 T33 K34 T37 K38 R39 K40 R41 H42 R44 K46 M48 S50 K51 G52 D53 L56 Y63 P1 K2 I3 K4 T5 V6 R7 K11 R12 T16 G17 K18 K22 H23 H25 A26 N27 R29 H30 I31 L32 T33 K34 T37 K38 R39 K40 R41 H42 R44 K46 M48 S50 K51 G52 D53 L56 Y63 P0A7Q1 PKIKTVRGAAKRFKKTGKGGFKHKHANLRHILTKKATKRKRHLRPKAMVSKGDLGLVIACLPYA 3j5l 4 6.60 BS01 NUC A 1 M1 K2 R4 A5 S6 V7 K8 K15 I16 V17 K18 R19 D20 I23 R24 P31 K32 K34 R36 Q37 G38 M1 K2 R4 A5 S6 V7 K8 K15 I16 V17 K18 R19 D20 I23 R24 P31 K32 K34 R36 Q37 G38 P0A7Q6 MKVRASVKKLCRNCKIVKRDGVIRVICSAEPKHKQRQG 3j5l C 6.60 BS01 NUC A 1 K6 P7 T8 S9 P10 G11 R12 R13 H14 K17 V19 H24 G26 K27 E34 K35 S37 K38 S39 G41 R42 N43 N44 N45 G46 R47 I48 T49 T50 R51 H52 G55 H57 K58 Q59 A60 Y61 R62 F66 K67 I73 Y82 P84 N85 R86 K96 D97 G98 R100 M145 K146 P147 G148 K149 Q152 L153 A154 R155 S156 A157 G158 T159 Y170 L175 R176 S177 E179 R181 E184 A197 H199 M200 V203 L204 G205 K206 A207 G208 A210 R211 W212 R213 R216 P217 T218 V219 R220 G221 T222 A223 M224 N225 P226 V227 D228 H231 G233 G234 E235 G236 R237 N238 F239 G240 K241 H242 V244 T245 P246 W247 T251 K252 G253 K254 K255 T256 R257 N259 R261 T262 I266 R269 R270 K6 P7 T8 S9 P10 G11 R12 R13 H14 K17 V19 H24 G26 K27 E34 K35 S37 K38 S39 G41 R42 N43 N44 N45 G46 R47 I48 T49 T50 R51 H52 G55 H57 K58 Q59 A60 Y61 R62 F66 K67 I73 Y82 P84 N85 R86 K96 D97 G98 R100 M145 K146 P147 G148 K149 Q152 L153 A154 R155 S156 A157 G158 T159 Y170 L175 R176 S177 E179 R181 E184 A197 H199 M200 V203 L204 G205 K206 A207 G208 A210 R211 W212 R213 R216 P217 T218 V219 R220 G221 T222 A223 M224 N225 P226 V227 D228 H231 G233 G234 E235 G236 R237 N238 F239 G240 K241 H242 V244 T245 P246 W247 T251 K252 G253 K254 K255 T256 R257 N259 R261 T262 I266 R269 R270 P60422 AVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRS 3j5l D 6.60 BS01 NUC A 1 K8 M11 T12 R13 P23 Q36 N42 Y45 Q49 K56 N58 R59 T61 K62 P63 E64 G66 H67 K70 L79 E81 R83 S113 K114 G115 K116 G117 F118 A119 G120 K123 R124 N126 F127 R128 T129 Q130 A132 T133 H134 G135 N136 S137 L138 S139 H140 R141 P143 G144 S145 I146 G147 Q148 N149 Q150 T151 P152 G153 K154 V155 F156 K157 G158 K159 M161 A162 Q164 N167 R169 V170 T171 V172 Q173 S174 L175 K190 G191 V193 P194 G195 A196 T197 K208 K8 M11 T12 R13 P23 Q36 N42 Y45 Q49 K56 N58 R59 T61 K62 P63 E64 G66 H67 K70 L79 E81 R83 S113 K114 G115 K116 G117 F118 A119 G120 K123 R124 N126 F127 R128 T129 Q130 A132 T133 H134 G135 N136 S137 L138 S139 H140 R141 P143 G144 S145 I146 G147 Q148 N149 Q150 T151 P152 G153 K154 V155 F156 K157 G158 K159 M161 A162 Q164 N167 R169 V170 T171 V172 Q173 S174 L175 K190 G191 V193 P194 G195 A196 T197 K208 P60438 MIGLVGKKVGMTRIFTEDGVSIPVTVIEVEANRVTQVKDLANDGYRAIQVTTGAKKANRVTKPEAGHFAKAGVEAGRGLWEFRLAEGEEFTVGQSISVELFADVKKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGKVFKGKKMAGQMGNERVTVQSLDVVRVDAERNLLLVKGAVPGATGSDLIVKPAVKA 3j5l E 6.60 BS01 NUC A 1 N24 H29 Q30 V33 Y35 A36 A39 R40 Q41 T43 R44 A45 Q46 K47 R49 A50 V52 T53 S55 G56 K57 K58 Q62 K63 G64 G66 R67 R69 G71 S72 S75 P76 I77 W78 R79 S80 V83 T84 F85 Q90 K95 V96 N97 K98 K99 M100 Y101 R102 P129 K130 T131 L159 R162 N163 H165 N24 H29 Q30 V33 Y35 A36 A39 R40 Q41 T43 R44 A45 Q46 K47 R49 A50 V52 T53 S55 G56 K57 K58 Q62 K63 G64 G66 R67 R69 G71 S72 S75 P76 I77 W78 R79 S80 V83 T84 F85 Q90 K95 V96 N97 K98 K99 M100 Y101 R102 P129 K130 T131 L159 R162 N163 H165 P60723 MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA 3j5l F 6.60 BS02 NUC B 1 S23 V24 M25 Q26 K63 L65 K68 V88 T89 R91 R94 S23 V24 M25 Q26 K63 L65 K68 V88 T89 R91 R94 P62399 AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLDNAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDEEGRALLAAFDFPFR 3j5l G 6.60 BS01 NUC A 1 S1 R2 V3 A62 Q63 G65 T66 A69 L70 G107 F108 S109 H110 K137 Q138 G141 Q142 A145 R151 P155 Y156 K157 K159 K171 A173 K174 K176 S1 R2 V3 A62 Q63 G65 T66 A69 L70 G107 F108 S109 H110 K137 Q138 G141 Q142 A145 R151 P155 Y156 K157 K159 K171 A173 K174 K176 P0AG55 SRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK 3j5l H 6.60 BS01 NUC A 1 N11 K22 A23 G24 Y25 N28 F29 N11 K22 A23 G24 Y25 N28 F29 P0A7R1 MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNIEFFEARRAELEA 3j5l J 6.60 BS01 NUC A 1 K2 T3 P8 L25 G26 R27 T30 R37 K39 H47 Y53 T65 G66 K68 K72 Y74 Y75 H76 H77 T78 H80 I81 G82 I84 R96 E102 I103 A104 G107 M108 P110 K111 P113 L114 R116 R120 K123 N131 H132 A134 Q135 Q136 K2 T3 P8 L25 G26 R27 T30 R37 K39 H47 Y53 T65 G66 K68 K72 Y74 Y75 H76 H77 T78 H80 I81 G82 I84 R96 E102 I103 A104 G107 M108 P110 K111 P113 L114 R116 R120 K123 N131 H132 A134 Q135 Q136 P0AA10 MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNADKVAVTGNKRTDKVYYHHTGHIGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMFRKLKVYAGNEHNHAAQQPQVLDI 3j5l K 6.60 BS01 NUC A 1 M1 Q3 E4 Q5 T6 M7 I22 K23 L25 G26 G27 S28 H29 R30 R31 Y32 K40 T42 K44 G55 V57 K66 K67 R70 V76 R78 N82 M1 Q3 E4 Q5 T6 M7 I22 K23 L25 G26 G27 S28 H29 R30 R31 Y32 K40 T42 K44 G55 V57 K66 K67 R70 V76 R78 N82 P0ADY3 MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEV 3j5l L 6.60 BS01 NUC A 1 L3 N4 L6 S7 P8 A9 E10 G11 S12 K13 K14 A15 G16 K17 R18 L19 G20 R21 G22 G24 S25 G28 K29 T30 G32 R33 G34 H35 K36 G37 Q38 K39 R41 S42 G43 V46 R47 R48 F50 E51 G52 G53 Q54 M55 Y58 R59 R60 L61 P62 K63 F64 G65 F66 T67 S68 R69 K70 A71 E76 R78 N99 I103 Q104 K109 I111 L112 R126 T128 K129 G130 L2 N3 L5 S6 P7 A8 E9 G10 S11 K12 K13 A14 G15 K16 R17 L18 G19 R20 G21 G23 S24 G27 K28 T29 G31 R32 G33 H34 K35 G36 Q37 K38 R40 S41 G42 V45 R46 R47 F49 E50 G51 G52 Q53 M54 Y57 R58 R59 L60 P61 K62 F63 G64 F65 T66 S67 R68 K69 A70 E75 R77 N98 I102 Q103 K108 I110 L111 R125 T127 K128 G129 P02413 RLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEIRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE 3j5l M 6.60 BS01 NUC A 1 P4 K5 R6 K8 F9 K11 M12 H13 K14 G15 R16 Q22 G23 F28 R40 R44 Q45 A48 R55 K62 W64 R66 F68 E75 K76 L78 A79 V80 R81 M82 G83 K84 G85 K86 G87 L119 A122 K123 L124 P125 K127 P4 K5 R6 K8 F9 K11 M12 H13 K14 G15 R16 Q22 G23 F28 R40 R44 Q45 A48 R55 K62 W64 R66 F68 E75 K76 L78 A79 V80 R81 M82 G83 K84 G85 K86 G87 L119 A122 K123 L124 P125 K127 P0ADY7 MLQPKRTKFRKMHKGRNRGLAQGTDVSFGSFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLAVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM 3j5l N 6.60 BS01 NUC A 1 M1 R2 H3 R4 K5 S6 R8 Q9 L10 N11 R12 N13 S14 H16 R17 Q18 A19 M20 N23 S27 H31 I34 K35 T36 T37 P39 K40 K42 R45 R46 E49 P50 T53 V60 A61 R63 R64 F67 A68 R69 R71 N73 E74 A77 R90 A91 G92 G93 Y94 T95 R96 K99 R103 G105 D106 N107 A108 P109 M1 R2 H3 R4 K5 S6 R8 Q9 L10 N11 R12 N13 S14 H16 R17 Q18 A19 M20 N23 S27 H31 I34 K35 T36 T37 P39 K40 K42 R45 R46 E49 P50 T53 V60 A61 R63 R64 F67 A68 R69 R71 N73 E74 A77 R90 A91 G92 G93 Y94 T95 R96 K99 R103 G105 D106 N107 A108 P109 P0AG44 MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRSE 3j5l O 6.60 BS02 NUC B 1 K3 R15 R25 R30 T31 P32 R33 H34 Y36 I40 G44 S45 E46 V47 V54 K63 Y64 N67 K68 Q98 H100 G101 R102 K2 R14 R24 R29 T30 P31 R32 H33 Y35 I39 G43 S44 E45 V46 V53 K62 Y63 N66 K67 Q97 H99 G100 R101 P0C018 DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF 3j5l Q 6.60 BS01 NUC A 1 A1 R2 V3 K4 R5 G6 V7 I8 R10 R12 H13 K14 K15 K18 K21 G22 Y23 Y24 G25 A26 R27 R29 V30 Y31 R32 V33 F35 Q36 K40 A41 Y44 A45 Y46 R47 D48 R49 R50 Q51 R52 K53 R54 Q55 F56 R57 Q58 W60 I61 N65 R69 S74 Y75 S76 N80 K84 R91 K92 I93 A1 R2 V3 K4 R5 G6 V7 I8 R10 R12 H13 K14 K15 K18 K21 G22 Y23 Y24 G25 A26 R27 R29 V30 Y31 R32 V33 F35 Q36 K40 A41 Y44 A45 Y46 R47 D48 R49 R50 Q51 R52 K53 R54 Q55 F56 R57 Q58 W60 I61 N65 R69 S74 Y75 S76 N80 K84 R91 K92 I93 P0A7L3 ARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA 3j5l T 6.60 BS01 NUC A 1 M1 I2 H15 E18 K19 A20 M24 T39 K40 N59 T60 L61 V62 K64 K66 V67 K68 H70 Q72 R73 G75 R76 R77 S78 K81 K82 Y84 M1 I2 H15 E18 K19 A20 M24 T39 K40 N59 T60 L61 V62 K64 K66 V67 K68 H70 Q72 R73 G75 R76 R77 S78 K81 K82 Y84 P0ADZ0 MIREERLLKVLRAPHVSEKASTAMEKSNTIVLKVAKDATKAEIKAAVQKLFEVEVEVVNTLVVKGKVKRHGQRIGRRSDWKKAYVTLKEGQNL 3j5l U 6.60 BS01 NUC A 1 A1 K3 R5 R6 T14 G15 K16 K18 V27 K43 H44 P47 G55 G56 Q65 S67 N68 K78 R81 G83 F84 K90 K91 K96 A1 K3 R5 R6 T14 G15 K16 K18 V27 K43 H44 P47 G55 G56 Q65 S67 N68 K78 R81 G83 F84 K90 K91 K96 P60624 AAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETI 3j5l W 6.60 BS01 NUC A 1 S8 T9 R10 N11 G12 D14 E16 A17 K18 R19 L20 V22 K23 R24 F25 E28 V30 L31 A32 I35 V37 R38 Q39 R40 G41 F44 G53 R54 D55 H56 F59 F68 R76 K77 S3 T4 R5 N6 G7 D9 E11 A12 K13 R14 L15 V17 K18 R19 F20 E23 V25 L26 A27 I30 V32 R33 Q34 R35 G36 F39 G48 R49 D50 H51 F54 F63 R71 K72 P0A7L8 GGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE 3j5l X 6.60 BS01 NUC A 1 S1 R2 K9 R10 V12 T13 G14 N15 N16 R17 S18 H19 A20 L21 N22 K25 R26 R27 F28 L29 P30 N31 H33 H35 R36 T47 R49 A52 K53 M55 R56 K60 K61 S1 R2 K9 R10 V12 T13 G14 N15 N16 R17 S18 H19 A20 L21 N22 K25 R26 R27 F28 L29 P30 N31 H33 H35 R36 T47 R49 A52 K53 M55 R56 K60 K61 P0A7M2 SRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRVSAKGMRVIDKKGIDTVLAELRARGEKY 3j5l Y 6.60 BS01 NUC A 1 K2 A3 L6 Q38 Q39 S40 H41 K44 R47 R48 A51 R52 K54 T55 N58 K2 A3 L6 Q38 Q39 S40 H41 K44 R47 R48 A51 R52 K54 T55 N58 P0A7M6 MKAKELREKSVEELNTELLNLLREQFNLRMQAASGQLQQSHLLKQVRRDVARVKTLLNEKAGA 3j5l Z 6.60 BS01 NUC A 1 S11 I13 G14 L16 P17 K18 A21 T22 L24 G25 G27 R29 R30 I31 R37 E38 A42 G45 M46 S11 I13 G14 L16 P17 K18 A21 T22 L24 G25 G27 R29 R30 I31 R37 E38 A42 G45 M46 P0AG51 AKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAIRGMINAVSFMVKVEE 3w8q A 2.20 BS01 AGS A 1 L74 A76 G77 N78 G79 V82 A95 K97 I99 V127 M143 E144 M146 S150 Q153 S194 N195 L197 C207 F209 G210 V211 S212 L36 A38 G39 N40 G41 V44 A57 K59 I61 V89 M105 E106 M108 S112 Q115 S156 N157 L159 C169 F171 G172 V173 S174 2.7.12.2 Q02750 ELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3w8r A 2.50 BS01 CTN A 1 T15 D40 Y43 Y59 D60 Y88 F90 H93 R142 R152 Q160 V165 T11 D36 Y39 Y55 D56 Y84 F86 H89 R138 R148 Q156 V161 2.7.1.48 Q5SKR5 KPFVIGIAGGTASGKTTLAQALARTLGERVALLPMDHYYKDLGHLPLEERLRVNYDHPDAFDLALYLEHAQALLRGLPVEMPVYDFRAHTRSPRRTPVRPAPVVILEGILVLYPKELRDLMDLKVFVDADADERFIRRLKRDVLERGRSLEGVVAQYLEQVKPMHLHFVEPTKRYADVIVPRGGQNPVALEMLAAKALARLARMGAA 3w8r A 2.50 BS02 ACP A 1 G14 T15 A16 S17 G18 K19 T20 T21 D40 R145 G10 T11 A12 S13 G14 K15 T16 T17 D36 R141 2.7.1.48 Q5SKR5 KPFVIGIAGGTASGKTTLAQALARTLGERVALLPMDHYYKDLGHLPLEERLRVNYDHPDAFDLALYLEHAQALLRGLPVEMPVYDFRAHTRSPRRTPVRPAPVVILEGILVLYPKELRDLMDLKVFVDADADERFIRRLKRDVLERGRSLEGVVAQYLEQVKPMHLHFVEPTKRYADVIVPRGGQNPVALEMLAAKALARLARMGAA 3w8r B 2.50 BS02 ACP B 1 T15 A16 S17 G18 K19 T20 T21 R145 T12 A13 S14 G15 K16 T17 T18 R142 2.7.1.48 Q5SKR5 PKPFVIGIAGGTASGKTTLAQALARTLGERVALLPMDHYYKDLGHLPLEERLRVNYDHPDAFDLALYLEHAQALLRGLPVEMPVYDFRAHTRSPRRTPVRPAPVVILEGILVLYPKELRDLMDLKVFVDADADERFIRRLKRDVLERGRSLEGVVAQYLEQVKPMHLHFVEPTKRYADVIVPRGGQNPVALEMLAAKALARLARMG 3wbb A 1.93 BS01 NAP A 1 G10 Y11 G12 N13 V14 R35 R36 C67 V68 P69 T70 Y76 S90 D92 G120 W121 D122 P123 N253 T257 G8 Y9 G10 N11 V12 R33 R34 C65 V66 P67 T68 Y74 S88 D90 G118 W119 D120 P121 N251 T255 1.4.1.16 Q67PI3 24339368 KLRVAVVGYGNVGRYALEAVQAAPDMELVGVVRRKVLAATPPELTGVRVVTDISQLEGVQGALLCVPTRSVPEYAEAMLRRGIHTVDSYDIHGDLADLRRRLDPVAREHGAAAVISAGWDPGTDSIIRALLEFMAPKGITYTNFGPGMSMGHSVAVKAIPGVRDALSMTIPAGMGVHKRAVYVELEPGADFAEVERAIKTDPYFVRDETRVTQVESVSALMDVGHGVVMERKGVSGATHNQLFRFEMRINNPALTAQVMVAALRAAARQKPGCYTMIEIPVIDYLPGDREAWIRKLV 3wbf A 2.12 BS01 API A 1 D92 W121 D122 F146 S151 M152 G153 H154 T171 R181 H227 N253 D90 W119 D120 F144 S149 M150 G151 H152 T169 R179 H225 N251 1.4.1.16 Q67PI3 24339368 KLRVAVVGYGNVGRYALEAVQAAPDMELVGVVRRKVLAATPPELTGVRVVTDISQLEGVQGALLCVPTRSVPEYAEAMLRRGIHTVDSYDIHGDLADLRRRLDPVAREHGAAAVISAGWDPGTDSIIRALLEFMAPKGITYTNFGPGMSMGHSVAVKAIPGVRDALSMTIPAGMGVHKRAVYVELEPGADFAEVERAIKTDPYFVRDETRVTQVESVSALMDVGHGVVMERKGVSGATHNQLFRFEMRINNPALTAQVMVAALRAAARQKPGCYTMIEIPVIDYLPGDREAWIRKLV 3wbf A 2.12 BS02 NAP A 1 G10 Y11 G12 N13 V14 R35 R36 C67 V68 P69 T70 Y76 S90 D92 G120 W121 D122 P123 M152 G153 V156 K159 N253 T257 G8 Y9 G10 N11 V12 R33 R34 C65 V66 P67 T68 Y74 S88 D90 G118 W119 D120 P121 M150 G151 V154 K157 N251 T255 1.4.1.16 Q67PI3 24339368 KLRVAVVGYGNVGRYALEAVQAAPDMELVGVVRRKVLAATPPELTGVRVVTDISQLEGVQGALLCVPTRSVPEYAEAMLRRGIHTVDSYDIHGDLADLRRRLDPVAREHGAAAVISAGWDPGTDSIIRALLEFMAPKGITYTNFGPGMSMGHSVAVKAIPGVRDALSMTIPAGMGVHKRAVYVELEPGADFAEVERAIKTDPYFVRDETRVTQVESVSALMDVGHGVVMERKGVSGATHNQLFRFEMRINNPALTAQVMVAALRAAARQKPGCYTMIEIPVIDYLPGDREAWIRKLV 3wbf B 2.12 BS01 API B 1 D92 D122 F146 S151 M152 G153 H154 T171 R181 H227 N253 D90 D120 F144 S149 M150 G151 H152 T169 R179 H225 N251 1.4.1.16 Q67PI3 24339368 KLRVAVVGYGNVGRYALEAVQAAPDMELVGVVRRKVLAATPPELTGVRVVTDISQLEGVQGALLCVPTRSVPEYAEAMLRRGIHTVDSYDIHGDLADLRRRLDPVAREHGAAAVISAGWDPGTDSIIRALLEFMAPKGITYTNFGPGMSMGHSVAVKAIPGVRDALSMTIPAGMGVHKRAVYVELEPGADFAEVERAIKTDPYFVRDETRVTQVESVSALMDVGHGVVMERKGVSGATHNQLFRFEMRINNPALTAQVMVAALRAAARQKPGCYTMIEIPVIDYLPGDREAWIRKLV 3wh1 A 1.00 BS01 NAG A 1 Q60 G63 F67 I176 Q180 N183 Q59 G62 F66 I174 Q178 N181 3.2.1.14 A9ZSX9 24582745 SWTSFVTPAVFEGWFPNRNPFYTYDGLVSASNGYPEFGTTGSLDDQKRELAAFLGNINQASGGLQFIQEQNPSDYCDTSSTQYPCAAGKQYYGRGPIQLSWNYNYGEAGADLGLDLLNNPDLVAQDSTVAWRTALWFWMKRDCHGAITASPPSFSGTIRIINGGLECNQPAGSIGNMQMENRVTYYTQFCQTLGVDPGTDLRC 3wh1 A 1.00 BS02 NAG A 2 Q60 A61 F67 E70 Q71 Q100 E168 Q180 Q59 A60 F66 E69 Q70 Q98 E166 Q178 3.2.1.14 A9ZSX9 24582745 SWTSFVTPAVFEGWFPNRNPFYTYDGLVSASNGYPEFGTTGSLDDQKRELAAFLGNINQASGGLQFIQEQNPSDYCDTSSTQYPCAAGKQYYGRGPIQLSWNYNYGEAGADLGLDLLNNPDLVAQDSTVAWRTALWFWMKRDCHGAITASPPSFSGTIRIINGGLECNQPAGSIGNMQMENRVTYYTQFCQTLGVDPGTDLRC 3wh1 A 1.00 BS03 NAG A 3 I99 Q100 S102 I163 N164 L167 I97 Q98 S100 I161 N162 L165 3.2.1.14 A9ZSX9 24582745 SWTSFVTPAVFEGWFPNRNPFYTYDGLVSASNGYPEFGTTGSLDDQKRELAAFLGNINQASGGLQFIQEQNPSDYCDTSSTQYPCAAGKQYYGRGPIQLSWNYNYGEAGADLGLDLLNNPDLVAQDSTVAWRTALWFWMKRDCHGAITASPPSFSGTIRIINGGLECNQPAGSIGNMQMENRVTYYTQFCQTLGVDPGTDLRC 3wh1 A 1.00 BS04 NAG A 4 I99 L101 S102 W103 N106 F139 I163 N164 I97 L99 S100 W101 N104 F137 I161 N162 3.2.1.14 A9ZSX9 24582745 SWTSFVTPAVFEGWFPNRNPFYTYDGLVSASNGYPEFGTTGSLDDQKRELAAFLGNINQASGGLQFIQEQNPSDYCDTSSTQYPCAAGKQYYGRGPIQLSWNYNYGEAGADLGLDLLNNPDLVAQDSTVAWRTALWFWMKRDCHGAITASPPSFSGTIRIINGGLECNQPAGSIGNMQMENRVTYYTQFCQTLGVDPGTDLRC 3whk A 2.60 BS01 ATP A 1 D182 G184 G225 C226 G227 K228 T229 L230 D281 I360 H364 G388 A389 D15 G17 G58 C59 G60 K61 T62 L63 D110 I179 H183 G207 A208 P33297 MGFEVVERPNVTYNDIGGLKKQLQELREAIELPLKHPELFEEVGIDPPKGVLLYGPPGCGKTLMAKAIAHEVNATFIRVVGSELVREGARLVHELFELAKEKAPTIIFIDEIDAIGAKEVNRTLMQLLAEMDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRLIEVPLPDEFSRAQILQIHSRKMTTDDDINWQELARSTDEFNGAQLKAVTVEAGMIALRNGQSSVKHEDFVEGISEVQARKSKS 3whk C 2.60 BS01 ATP C 1 D182 G184 L186 G225 C226 G227 K228 T229 L230 D281 I360 H364 G388 A389 K392 D15 G17 L19 G58 C59 G60 K61 T62 L63 D110 I177 H181 G205 A206 K209 P33297 MGFEVVERPNVTYNDIGGLKKQLQELREAIELPLKHPELFEEVGIDPPKGVLLYGPPGCGKTLMAKAIAHEVNATFIRVVGSELVREGARLVHELFELAKEKAPTIIFIDEIDAIGAKNRTLMQLLAEMDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRLIEVPLPDEFSRAQILQIHSRKMTTDDDINWQELARSTDEFNGAQLKAVTVEAGMIALRNGQSSVKHEDFVEGISEVQARKSK 3whk F 2.60 BS01 ATP F 1 D182 I183 G184 L186 P224 G225 C226 G227 K228 T229 L230 D281 H364 G388 A389 K392 D15 I16 G17 L19 P57 G58 C59 G60 K61 T62 L63 D110 H183 G207 A208 K211 P33297 MGFEVVERPNVTYNDIGGLKKQLQELREAIELPLKHPELFEEVGIDPPKGVLLYGPPGCGKTLMAKAIAHEVNATFIRVVGSELVREGARLVHELFELAKEKAPTIIFIDEIDAIGAKEVNRTLMQLLAEMDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRLIEVPLPDEFSRAQILQIHSRKMTTDDDINWQELARSTDEFNGAQLKAVTVEAGMIALRNGQSSVKHEDFVEGISEVQAR 3wi8 A 2.20 BS01 HNN A 1 F43 V68 L89 S92 H93 H97 I99 Y103 I107 F138 F43 V68 L89 S92 H93 H97 I99 Y103 I107 F138 P68082 24191678 GLSDGEWQQVLNVWGKVEADIAGHGQEVLIRLFTGHPETLEKFDKFKHLKTEAEMKASEDLKKHGTVVLTALGGILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISDAIIHVLHSKHPGDFGADAQGAMTKALELFRNDIAAKYKELGF 3ws3 A 2.33 BS01 III E 1 Y31 E33 Y46 S48 Y69 R86 E87 K90 Q94 W97 S101 L105 Y108 L119 Q121 L138 F140 T167 W171 S174 A176 H179 Y180 Y183 E187 W191 Y195 Y6 E8 Y21 S23 Y44 R61 E62 K65 Q69 W72 S76 L80 Y83 L94 Q96 L113 F115 T142 W146 S149 A151 H154 Y155 Y158 E162 W166 Y170 P01899 PHSMRYFETAVSRPGLEEPRYISVGYVDNKEFVRFDSDAENPRYEPRAPWMEQEGPEYWERETQKAKGQEQWFRVSLRNLLGYYNQSAGGSHTLQQMSGCDLGSDWRLLRGYLQFAYEGRDYIALNEDLKTWTAADMAAQITRRKWEQSGAAEHYKAYLEGECVEWLHRYLKNGLLRTDSPKAHVTHHPRSEVTLRCWALGFYPADITLTWQGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVYHEGLPEPLTLRW 3ws3 C 2.33 BS01 III F 1 Y31 E33 Y46 Y69 R86 E87 K90 Q94 W97 S101 N104 L105 Y108 Q121 Y147 T167 K170 W171 S174 H179 Y180 Y183 E187 W191 Y195 Y6 E8 Y19 Y42 R59 E60 K63 Q67 W70 S74 N77 L78 Y81 Q94 Y120 T140 K143 W144 S147 H152 Y153 Y156 E160 W164 Y168 P01899 PHSMRYFETAVSRPEEPRYISVGYVDNKEFVRFDSDAENPRYEPRAPWMEQEGPEYWERETQKAKGQEQWFRVSLRNLLGYYNQSAGGSHTLQQMSGCDLGSDWRLLRGYLQFAYEGRDYIALNEDLKTWTAADMAAQITRRKWEQSGAAEHYKAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHPRSKGEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVYHEGLPEPLTLRW 3ws6 A 1.98 BS01 III E 1 Y31 E33 Y69 R86 E87 K90 Q94 W97 V100 S101 N104 L105 Y108 L119 Q121 S123 T167 K170 W171 S174 A176 H179 Y180 Y183 E187 W191 Y195 Y6 E8 Y44 R61 E62 K65 Q69 W72 V75 S76 N79 L80 Y83 L94 Q96 S98 T142 K145 W146 S149 A151 H154 Y155 Y158 E162 W166 Y170 P01899 PHSMRYFETAVSRPGLEEPRYISVGYVDNKEFVRFDSDAENPRYEPRAPWMEQEGPEYWERETQKAKGQEQWFRVSLRNLLGYYNQSAGGSHTLQQMSGCDLGSDWRLLRGYLQFAYEGRDYIALNEDLKTWTAADMAAQITRRKWEQSGAAEHYKAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHPRSKGEVTLRCWALGFYPADITLTWQLNGEELTMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVYHEGLPEPLTLRWEP 4be7 B 2.74 BS01 ATP B 1 R220 L270 V271 M272 R273 Q276 T309 G310 S311 G312 K313 T314 L315 T661 D664 R688 R691 R192 L242 V243 M244 R245 Q248 T281 G282 S283 G284 K285 T286 L287 T625 D628 R652 R655 3.1.21.3 P10486 NFIVLDKYIKAEPTGDSYQSESDLERELIQDLRNQGYEFISVKSQSAMLANVREQLQNLNGVVFNDSEWRRFTEQYLDNPSDGILDKTRKIHIDYICDFIFDDERLENIYLIDKKNLMRNKVQIIQQFRYDVTILVNGLPLVQIELKKRGVAIREAFNQINSENSLFKYLQLFVISNGTDTRYFANTTKRDRNSFDFTMNWAKSDNTLIKDLKDFTATCFQKHTLLNVLVNYSVFDSSQTLLVMRPYQIAATERILWKIKSSFTAKNWSKPESGGYIWHTTGSGKTLTSFKAARLATELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSENTAGLKRNLDKDDNKIIVTTIQKLNNLMKAESDLPVYNQQVVFIFDECHRSQFGEAQKNLKKKFKRYYQFGFTGTPIFPENALGSETTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPQFKSLETETDEKKLSAAENQQAFLHPMRIQEITQYILNNFRQKTHRTFPGSKGFNAMLAVSSVDAAKAYYATFKRLQEEAANKSATYKPLRIATIFSFAGEISDETFDTSAMDSSAKEFLDAAIREYNSHFKTNFSTDSNGFQNYYRDLAQRVKNQDIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLMQAFSRTNRIYDATKTFGNIVTFRDLERSTIDAITLFGDKNTKNVVLEKSYTEYMEGFTDAATGEAKRGFMTVVSELEQRFPDPTSIESEKEKKDFVKLFGEYLRAENILQNYDEFATLKALQQIDLSDPVAVEKFKAEHYVDDEKFAELQTIRLPADRKIQDYRSAYNDIRDWQRRWDDVVFEVDLLKSQ 4be9 A 2.00 BS01 7P9 A 1 D455 F458 L470 Q471 V476 L477 A522 D444 F447 L459 Q460 V465 L466 A511 3.1.1.13 Q2TFW1 FTTVNVNYPEGEVVGVSVLGIESFRGVPFAQPPVGNLRLKPPVRYTENIGTKDTTGIGPSCPQMYLSTGNGELLFQLVGNLINIPLFQTATLSSEDCLTLNIQRPAGTTSNSSLPVLFWIFGGGFELGTNQYYDGIDLLTEGISLGEPFIFVAINYRVGGFGFLGGKEIKADGSSNLGLLDQRIALEWVADNIASFGGDPSKVTIWGESAGSISVFDQMALYGGNNKYKGKALFRGGIMNSGSVVPAAPVDGVKAQAIYDHVVSEAGCAGTSDTLACLRTVDYTKFLTAVNSVPGIVSYSSIALSYLPRPDGVVLIDSPEEIVKNKQYAAVPMIIGDQEDEGTLFAVLPNNITSTAKIVQYFQDLYFYNATKEQLTAFVNTYPTDITAGSPFNTGIFNELYPGFKRLAAILGDMTFTLARRAFLQLCSEVNPDVPSWSYLASYDYGFPFLGTFHATDILQVFYGVLPNYASGSIQKYYINFVTTGDPNKGAAVDIQWPQWSAKKNILQIYATKAVIVADNFRAKSYEYLYNNIGIFRI 4be9 A 2.00 BS02 7P9 B 1 L97 F98 L86 F87 3.1.1.13 Q2TFW1 FTTVNVNYPEGEVVGVSVLGIESFRGVPFAQPPVGNLRLKPPVRYTENIGTKDTTGIGPSCPQMYLSTGNGELLFQLVGNLINIPLFQTATLSSEDCLTLNIQRPAGTTSNSSLPVLFWIFGGGFELGTNQYYDGIDLLTEGISLGEPFIFVAINYRVGGFGFLGGKEIKADGSSNLGLLDQRIALEWVADNIASFGGDPSKVTIWGESAGSISVFDQMALYGGNNKYKGKALFRGGIMNSGSVVPAAPVDGVKAQAIYDHVVSEAGCAGTSDTLACLRTVDYTKFLTAVNSVPGIVSYSSIALSYLPRPDGVVLIDSPEEIVKNKQYAAVPMIIGDQEDEGTLFAVLPNNITSTAKIVQYFQDLYFYNATKEQLTAFVNTYPTDITAGSPFNTGIFNELYPGFKRLAAILGDMTFTLARRAFLQLCSEVNPDVPSWSYLASYDYGFPFLGTFHATDILQVFYGVLPNYASGSIQKYYINFVTTGDPNKGAAVDIQWPQWSAKKNILQIYATKAVIVADNFRAKSYEYLYNNIGIFRI 4be9 B 2.00 BS01 7P9 B 1 D455 F458 F464 L470 Q471 V476 L477 D443 F446 F452 L458 Q459 V464 L465 3.1.1.13 Q2TFW1 TTVNVNYPEGEVVGVSVLGIESFRGVPFAQPPVGNLRLKPPVRYTENIGTKDTTGIGPSCPQMYLSTGNGELLFQLVGNLINIPLFQTATLSSEDCLTLNIQRPAGTTSNSSLPVLFWIFGGGFELGTNQYYDGIDLLTEGISLGEPFIFVAINYRVGGFGFLGGKEIKADGSSNLGLLDQRIALEWVADNIASFGGDPSKVTIWGESAGSISVFDQMALYGGNNKYKGKALFRGGIMNSGSVVPAAPVDGVKAQAIYDHVVSEAGCAGTSDTLACLRTVDYTKFLTAVNSVPGIVSYSSIALSYLPRPDGVVLIDSPEEIVKNKQYAAVPMIIGDQEDEGTLFAVLPNNITSTAKIVQYFQDLYFYNATKEQLTAFVNTYPTDITAGSPFNTGIFNELYPGFKRLAAILGDMTFTLARRAFLQLCSEVNPDVPSWSYLASYDYGFPFLGTFHATDILQVFYGVLPNYASGSIQKYYINFVTTGDPNKGAAVDIQWPQWSAKKNILQIYATKAVIVADNFRAKSYEYLYNNIGIFRI 4beb A 2.99 BS02 ATP A 1 M227 L270 V271 M272 R273 Q276 T309 G310 S311 G312 K313 T314 L315 T661 G662 D664 R688 R691 M204 L247 V248 M249 R250 Q253 T286 G287 S288 G289 K290 T291 L292 T629 G630 D632 R656 R659 3.1.21.3 Q304R3 NFIVLDKYIKAEPTGDSYQSESDLERELIQDLRNQGYEFISVKSQSAMLANVREQLQNLNGVVFNDSEWRRFTEQYLDNPSDGILDKTRKIHIDYICDFIFDDERLENIYLIDKKNLMRNKVQIIQQFEQAGSHANRYDVTILVNGLPLVQIELKKRGVAIREAFNQINSLFKYLQLFVISNGTDTRYFANTTKRDENSFDFTMNWAKSDNTLIKDLKDFTATCFQKHTLLNVLVNYSVFDSSQTLLVMRPYQIAATERILWKIKSSFTAKNWSKPESGGYIWHTTGSGKTLTSFKAARLATELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSENTAGLKRNLDKDDNKIIVTTIQKLNNLMKAESDLPVYNQQVVFIFDECHRSQFGEAQKNLKKKFKRYYQFGFTGTPIFPENALGSETTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPQFKSLETETDEKKLSAAENQQAFLHPMRIQEITQYILNNFRQKTHRTFPGSKGFNAMLAVSSVDAAKAYYATFKRLQEEAANKSATYKPLRIATIFSFAEISDETFDTSAMDSSAKEFLDAAIREYNSHFKTNFSTDSNGFQNYYRDLAQRVKNQDIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLMQAFSRTNRIYDATKTFGNIVTFRDLERSTIDAITLFGDKNTKNVVLEKSYTEYMEGFTDAATGEAKRGFMTVVSELEQRFPDPTSIESEKEKKDFVKLFGEYLRAENILQNYDEFATLKALQQIDLSDPVAVEKFKAEHYVDDEKFAELQTIRLPADRKIQDYRSAYNDIRDWQRRWDDVVFEVDLLK 4beb B 2.99 BS01 MG B 1 K313 T314 D408 E409 K290 T291 D385 E386 3.1.21.3 Q304R3 NFIVLDKYIKAEPTGDSYQSESDLERELIQDLRNQGYEFISVKSQSAMLANVREQLQNLNGVVFNDSEWRRFTEQYLDNPSDGILDKTRKIHIDYICDFIFDDERLENIYLIDKKNLMRNKVQIIQQFEQAGSHANRYDVTILVNGLPLVQIELKKRGVAIREAFNQINSLFKYLQLFVISNGTDTRYFANTTKRDENSFDFTMNWAKSDNTLIKDLKDFTATCFQKHTLLNVLVNYSVFDSSQTLLVMRPYQIAATERILWKIKSSFTAKNWSKPESGGYIWHTTGSGKTLTSFKAARLATELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSENTAGLKRNLDKDDNKIIVTTIQKLNNLMKAESDLPVYNQQVVFIFDECHRSQFGEAQKNLKKKFKRYYQFGFTGTPIFPENALGSETTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPQFKSLETETDEKKLSAAENQQAFLHPMRIQEITQYILNNFRQKTHRTFPGSKGFNAMLAVSSVDAAKAYYATFKRLQEEAANKSATYKPLRIATIFSFAEISDETFDTSAMDSSAKEFLDAAIREYNSHFKTNFSTDSNGFQNYYRDLAQRVKNQDIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLMQAFSRTNRIYDATKTFGNIVTFRDLERSTIDAITLFGDKNTKNVVLEKSYTEYMEGFTDAATGEAKRGFMTVVSELEQRFPDPTSIESEKEKKDFVKLFGEYLRAENILQNYDEFATLKALQQIDLSDPVAVEKFKAEHYVDDEKFAELQTIRLPADRKIQDYRSAYNDIRDWQRRETDWDDVVFEVDLLK 4beb D 2.99 BS01 MG D 1 T314 D408 E409 T283 D377 E378 3.1.21.3 Q304R3 NFIVLDKYIKAEPTGDSYQSESDLERELIQDLRNQGYEFISVKSQSAMLANVREQLQNLNGVVFNDSEWRRFTEQYLDNPSDGILDKTRKIHIDYICDFIFDDERLENIYLIDKKNLMRNKVQIIQQFRYDVTILVNGLPLVQIELKKRGVAIREAFNQINSLFKYLQLFVISNGTDTRYFANTTKRDENSFDFTMNWAKSDNTLIKDLKDFTATCFQKHTLLNVLVNYSVFDSSQTLLVMRPYQIAATERILWKIKSSFTAKNWSKPESGGYIWHTTGSGKTLTSFKAARLATELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSENTAGLKRNLDKDDNKIIVTTIQKLNNLMKAESDLPVYNQQVVFIFDECHRSQFGEAQKNLKKKFKRYYQFGFTGTPIFPENALGSETTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPQFKSLETETDEKKLSAAENQQAFLHPMRIQEITQYILNNFRQKTHRTFPGSKGFNAMLAVSSVDAAKAYYATFKRLQEEAANKSATYKPLRIATIFSFAEISDETFDTSAMDSSAKEFLDAAIREYNSHFKTNFSTDSNGFQNYYRDLAQRVKNQDIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLMQAFSRTNRIYDATKTFGNIVTFRDLERSTIDAITLFGDKNTKNVVLEKSYTEYMEGFTDAATGEAKRGFMTVVSELEQRFPDPTSIESEKEKKDFVKLFGEYLRAENILQNYDEFATLKALQQIDLSDPVAVEKFKAEHYVDDEKFAELQTIRLPADRKIQDYRSAYNDIRDWQRRTDWDDVVFEVDLLK 4beb D 2.99 BS02 ATP D 1 M227 L270 V271 M272 R273 Q276 T309 G310 G312 K313 T314 T661 G662 D664 R688 R691 M196 L239 V240 M241 R242 Q245 T278 G279 G281 K282 T283 T621 G622 D624 R648 R651 3.1.21.3 Q304R3 NFIVLDKYIKAEPTGDSYQSESDLERELIQDLRNQGYEFISVKSQSAMLANVREQLQNLNGVVFNDSEWRRFTEQYLDNPSDGILDKTRKIHIDYICDFIFDDERLENIYLIDKKNLMRNKVQIIQQFRYDVTILVNGLPLVQIELKKRGVAIREAFNQINSLFKYLQLFVISNGTDTRYFANTTKRDENSFDFTMNWAKSDNTLIKDLKDFTATCFQKHTLLNVLVNYSVFDSSQTLLVMRPYQIAATERILWKIKSSFTAKNWSKPESGGYIWHTTGSGKTLTSFKAARLATELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSENTAGLKRNLDKDDNKIIVTTIQKLNNLMKAESDLPVYNQQVVFIFDECHRSQFGEAQKNLKKKFKRYYQFGFTGTPIFPENALGSETTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPQFKSLETETDEKKLSAAENQQAFLHPMRIQEITQYILNNFRQKTHRTFPGSKGFNAMLAVSSVDAAKAYYATFKRLQEEAANKSATYKPLRIATIFSFAEISDETFDTSAMDSSAKEFLDAAIREYNSHFKTNFSTDSNGFQNYYRDLAQRVKNQDIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLMQAFSRTNRIYDATKTFGNIVTFRDLERSTIDAITLFGDKNTKNVVLEKSYTEYMEGFTDAATGEAKRGFMTVVSELEQRFPDPTSIESEKEKKDFVKLFGEYLRAENILQNYDEFATLKALQQIDLSDPVAVEKFKAEHYVDDEKFAELQTIRLPADRKIQDYRSAYNDIRDWQRRTDWDDVVFEVDLLK 4bec B 2.84 BS01 ATP B 1 L270 V271 M272 R273 Q276 T309 G310 S311 G312 K313 T314 L315 D664 R688 R691 L251 V252 M253 R254 Q257 T290 G291 S292 G293 K294 T295 L296 D638 R662 R665 3.1.21.3 Q304R3 NNFIVLDKYIKAEPTGDSYQSESDLERELIQDLRNQGYEFISVKSQSAMLANVREQLQNLNGVVFNDSEWRRFTEQYLDNPSDGILDKTRKIHIDYICDFIFDDERLENIYLIDKKNLMRNKVQIIQQFRYDVTILVNGLPLVQIELKKRGVAIREAFNQIHRYSKESFNSENSLFKYLQLFVISNGTDTRYFANTTKRDANSFDFTMNWAKSDNTLIKDLKDFTATCFQKHTLLNVLVNYSVFDSSQTLLVMRPYQIAATERILWKIKSSFTAKNWSKPESGGYIWHTTGSGKTLTSFKAARLATELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSENTAGLKRNLDKDDNKIIVTTIQKLNNLMKAESDLPVYNQQVVFIFDECHRSQFGEAQKNLKKKFKRYYQFGFTGTPIFPENALGSETTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPQFKSLETETDEKKLSAAENQQAFLHPMRIQEITQYILNNFRQKTHRTFPGSKGFNAMLAVSSVDAAKAYYATFKRLQEEAANKSATYKPLRIATIFSFAIGEISDETFDTSAMDSSAKEFLDAAIREYNSHFKTNFSTDSNGFQNYYRDLAQRVKNQDIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLMQAFSRTNRIYDATKTFGNIVTFRDLERSTIDAITLFGDKNTKNVVLEKSYTEYMEGFTDAATGEAKRGFMTVVSELEQRFPDPTSIESEKEKKDFVKLFGEYLRAENILQNYDEFATLKALQQIDLSDPVAVEKFKAEHYVDDEKFAELQTIRLPADRKIQDYRSAYNDIRDWQRRWDDVVFEVDLLKS 4beo A 2.43 BS01 III G 1 Y7 Y9 E63 N66 V67 Y99 R114 A150 Q156 Y159 R163 W167 Y171 Y7 Y9 E63 N66 V67 Y99 R114 A150 Q156 Y159 R163 W167 Y171 P13746 GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWE 4beo A 2.43 BS02 III H 1 Y7 Y9 E63 N66 V67 D77 Y84 Y99 R114 D116 T143 K146 W147 Q155 Q156 Y159 W167 Y171 Y7 Y9 E63 N66 V67 D77 Y84 Y99 R114 D116 T143 K146 W147 Q155 Q156 Y159 W167 Y171 P13746 GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWE 4beo C 2.43 BS02 III F 1 Y7 Y9 E63 N66 V67 D77 Y84 Y99 D116 T143 K146 W147 A150 Q155 Q156 Y159 R163 W167 Y171 Y7 Y9 E63 N66 V67 D77 Y84 Y99 D116 T143 K146 W147 A150 Q155 Q156 Y159 R163 W167 Y171 P13746 GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWE 4bf4 A 2.70 BS01 HEM A 1 K72 M92 L93 H100 R104 F111 A243 G244 T247 T248 L251 L284 P289 T294 R296 A346 F347 G348 H352 C354 I355 A360 K62 M82 L83 H90 R94 F101 A233 G234 T237 T238 L241 L274 P279 T284 R286 A336 F337 G338 H342 C344 I345 A350 O87605 SPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4bf4 B 2.70 BS01 HEM B 1 K72 M92 L93 H100 R104 F111 L240 A243 G244 T247 T248 L251 P289 V290 A293 T294 R296 A346 F347 H352 C354 I355 A360 K63 M83 L84 H91 R95 F102 L231 A234 G235 T238 T239 L242 P280 V281 A284 T285 R287 A337 F338 H343 C345 I346 A351 O87605 ASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4bf4 C 2.70 BS02 17Q C 1 L81 E85 N89 L93 E94 I239 A243 T247 V290 T294 L71 E75 N79 L83 E84 I229 A233 T237 V280 T284 O87605 SPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4bf4 D 2.70 BS01 HEM D 1 M92 L93 H100 R104 I157 L240 A243 G244 T247 T248 L251 L284 P289 V290 A293 T294 R296 A346 F347 G348 H352 C354 I355 G356 A360 M83 L84 H91 R95 I148 L231 A234 G235 T238 T239 L242 L275 P280 V281 A284 T285 R287 A337 F338 G339 H343 C345 I346 G347 A351 O87605 ASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4bf4 F 2.70 BS01 HEM F 1 K72 M92 L93 H100 R104 F111 A243 G244 T247 T248 L251 P289 V290 A293 T294 R296 A346 F347 G348 I351 H352 C354 I355 G356 A360 K62 M82 L83 H90 R94 F101 A233 G234 T237 T238 L241 P279 V280 A283 T284 R286 A336 F337 G338 I341 H342 C344 I345 G346 A350 O87605 SPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4bf4 G 2.70 BS02 17Q G 1 L81 E85 N89 L93 E94 I239 A243 T247 T294 M394 L71 E75 N79 L83 E84 I229 A233 T237 T284 M384 O87605 SPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4bf4 J 2.70 BS01 HEM J 1 M92 L93 H100 R104 F111 A243 G244 T247 T248 L251 P289 A293 T294 R296 A346 F347 G348 H352 C354 I355 G356 A360 M83 L84 H91 R95 F102 A234 G235 T238 T239 L242 P280 A284 T285 R287 A337 F338 G339 H343 C345 I346 G347 A351 O87605 ASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4bf4 N 2.70 BS01 HEM N 1 M92 L93 H100 R104 I157 A243 G244 T247 T248 L251 V290 A293 T294 R296 L319 A346 F347 G348 H352 C354 I355 G356 A360 M83 L84 H91 R95 I148 A234 G235 T238 T239 L242 V281 A284 T285 R287 L310 A337 F338 G339 H343 C345 I346 G347 A351 O87605 ASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4bff A 2.00 BS01 FE2 A 1 H14 H40 H46 C110 H113 H13 H39 H45 C109 H112 1.15.1.2 O29903 ELFQTADWKKEKHVPVIEVLRAEGGVVEVKVSVGKEIPHPNTTEHHIAWIELVFQPEGSKFPYVVGRAEFAAHGASVDGPNTSGVYTDPVAVFAFKAEKSGKLTAFSYCNIHGLWMGEATLSL 4bn1 A 2.50 BS01 ADP A 1 L139 G140 K141 G142 K143 F144 G145 V147 A160 K162 L194 L210 E211 Y212 A213 T217 R220 E260 N261 L263 D274 L14 G15 K16 G17 K18 F19 G20 V22 A35 K37 L69 L85 E86 Y87 A88 T92 R95 E135 N136 L138 D149 2.7.11.1 O14965 23924325 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGMEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSS 4byf A 2.74 BS01 MG A 1 T112 S161 T104 S153 3.6.4.1 O00159 24636949 DRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANENAQVTTENQLKYLTRLLSVEGSTLREALTHRKIELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSEKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFL 4byf A 2.74 BS02 AOV A 1 N53 R56 Y61 S107 G108 G110 K111 T112 E113 N157 N159 S160 S161 Y388 G389 N45 R48 Y53 S99 G100 G102 K103 T104 E105 N149 N151 S152 S153 Y373 G374 3.6.4.1 O00159 24636949 DRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANENAQVTTENQLKYLTRLLSVEGSTLREALTHRKIELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSEKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFL 4byf C 2.74 BS02 AOV C 1 N53 P54 R56 Y61 E106 S107 G108 A109 G110 K111 T112 E113 N157 N159 S160 S161 Y388 G389 N44 P45 R47 Y52 E97 S98 G99 A100 G101 K102 T103 E104 N148 N150 S151 S152 Y372 G373 3.6.4.1 O00159 24636949 RVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANENAQVTTENQLKYLTRLLSVEGSTLREALTHRKIELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFL 4ch4 A 2.16 BS01 YLC A 1 Y306 R330 E332 H338 L339 F342 M344 N346 F347 C348 E396 L397 S398 S399 W417 G419 A420 G421 G423 R426 Y119 R143 E145 H149 L150 F153 M155 N157 F158 C159 E201 L202 S203 S204 W222 G224 A225 G226 G228 R231 6.1.1.26 Q8PWY1 PALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKDLQQIYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKEGKEHLEEFTMLNFCQMGSGCTRENLESIITDFLNHLGIDFKIVGGDTLDVMHGDLELSSAVVGPIPLDREWGIDKPWIGAGFGLERLLKVKHDFKNIKRAARSESYYNGISTNL 4cmd A 1.68 BS01 PLP A 1 R77 K179 E212 G215 F216 L234 G236 I237 T238 T273 T274 R77 K179 E212 G215 F216 L234 G236 I237 T238 T273 T274 2.6.1.42 C7YVL8 24618038 MATMDKVFAGYAERQAVLEASKNPLAKGVAWIQGELVPLHEARIPLLDQGFMHSDLTYDVPSVWDGRFFRLEDHLNRLEASCKKMRLRMPLPREEVIKTLVDMVAKSGIRDAFVELIVTRGLTGVRGAKPEELLNNNLYMFIQPYVWVMDPDVQYTGGRAIVARTVRRVPPGSIDPTIKNLQWGDLVRGLFEANDRGATYPFLTDGDANLTEGSGFNVVLIKDGVLYTPDRGVLQGITRKSVIDAARSCGYEIRVEHVPIEATYQADEILMCTTAGGIMPITTLDDKPVKDGKVGPITKAIWDRYWAMHWEDEFSFKINYLE 4cmd B 1.68 BS01 PLP B 1 R77 R168 K179 E212 G215 F216 N217 L234 G236 I237 T238 T273 T274 R77 R168 K179 E212 G215 F216 N217 L234 G236 I237 T238 T273 T274 2.6.1.42 C7YVL8 24618038 MATMDKVFAGYAERQAVLEASKNPLAKGVAWIQGELVPLHEARIPLLDQGFMHSDLTYDVPSVWDGRFFRLEDHLNRLEASCKKMRLRMPLPREEVIKTLVDMVAKSGIRDAFVELIVTRGLTGVRGAKPEELLNNNLYMFIQPYVWVMDPDVQYTGGRAIVARTVRRVPPGSIDPTIKNLQWGDLVRGLFEANDRGATYPFLTDGDANLTEGSGFNVVLIKDGVLYTPDRGVLQGITRKSVIDAARSCGYEIRVEHVPIEATYQADEILMCTTAGGIMPITTLDDKPVKDGKVGPITKAIWDRYWAMHWEDEFSFKINYLE 4cmf A 1.50 BS01 PXG A 1 Y58 V60 R77 F113 E115 K179 W183 E212 G215 F216 N217 L234 G236 I237 T238 T273 T274 A275 Y58 V60 R77 F113 E115 K179 W183 E212 G215 F216 N217 L234 G236 I237 T238 T273 T274 A275 2.6.1.42 C7YVL8 24618038 MATMDKVFAGYAERQAVLEASKNPLAKGVAWIQGELVPLHEARIPLLDQGFMHSDLTYDVPSVWDGRFFRLEDHLNRLEASCKKMRLRMPLPREEVIKTLVDMVAKSGIRDAFVELIVTRGLTGVRGAKPEELLNNNLYMFIQPYVWVMDPDVQYTGGRAIVARTVRRVPPGSIDPTIKNLQWGDLVRGLFEANDRGATYPFLTDGDANLTEGSGFNVVLIKDGVLYTPDRGVLQGITRKSVIDAARSCGYEIRVEHVPIEATYQADEILMCTTAGGIMPITTLDDKPVKDGKVGPITKAIWDRYWAMHWEDEFSFKINYLE 4hnw A 2.80 BS01 IHP A 1 K349 R426 K429 H430 K457 K460 Y461 R464 K333 R410 K413 H414 K441 K444 Y445 R448 P12945 IALKKENDQFLEALKLYEGKQYKKSLKLLDAILKKDGSHVDSLALKGLDLYSVGEKDDAASYVANAIRKIESASPICCHVLGIYMRNTKEYKESIKWFTAALNNGSTNKQIYRDLATLQSQIGDFKNALVSRKKYWEAFLGYRANWTSLAVAQDVNGERQQAINTLSQFEKLAEGKISDSEKYEHSECLMYKNDIMYKAASDNQDKLQNVLKHLNDIEPCVFDKFGLLERKATIYMKLGQLKDASIVYRTLIKRNPDNFKYYKLLEVSLGIQGDNKLKKALYGKLEQFYPRCEPPKFIPLTFLQDKEELSKKLREYVLPQLERGVPATFSNVKPLYQRRKSKVSPLLEKIVLDYLSGLDPTQDPIPFIWTNYYLSQHFLFLKDFPKAQEYIDAALDHTPTLVEFYILKARILKHLGLMDTAAGILEEGRQLDLQDRFINCKTVKYFLRANNIDKAVEVASLFTKNDDSVNGIKDLHLVEASWFIVEQAEAYYRLYLDRKKKLDDLASEQIANDIKENQWLVRKYKGLALKRFNAIPKFYKQFEDDQLDFHSYCMRKGTPRAYLEMLEWGKALYTKPMYVRAMKEASKLYFQMHDDRLKRSQKKKAKKEAAAMNKRKETEAKSVAAYPSDQDNDVFGEKLIETSTPMEDFATEFYNNYSMQVREDERDYILDFEFNYRIGKLALCFASLNKFAKRFGTTSGLFGSMAIVLLHATRNDTPFDPILKKVVTKSLEKNDINGLLFLYRYRDDVPIGSSNLKEMIISSLSPLEPHSQNEILQYYLYP 4hnw B 2.80 BS01 IHP A 1 Y85 K91 Y65 K71 2.3.1.88 P07347 PINIRRATINDIICMQNANLHNLPENYMMKYYMYHILSWPEASFVATTTTLDCEDGRTIKLDPTYLAPGEKLVGYVLVKMNDDPDQQNEPPNGHITSLSVMRTYRRMGIAENLMRQALFALREVHQAEYVSLHVRQSNRAALHLYRDTLAFEVLSIEKSYYQDGEDAYAMKKVLEEKLEDDLESDLLED 4hnx A 2.34 BS01 G4P A 1 K349 R426 K429 H430 K457 K460 Y461 R464 K331 R408 K411 H412 K439 K442 Y443 R446 P12945 KKENDQFLEALKLYEGKQYKKSLKLLDAILKKGSHVDSLALKGLDLYSVGEKDDAASYVANAIRKIEGASASPICCHVLGIYMRNTKEYKESIKWFTAALNNGSTNKQIYRDLATLQSQIGDFKNALVSRKKYWEAFLGYRANWTSLAVAQDVNGERQQAINTLSQFEKLAEGKISDSEKYEHSECLMYKNDIMYKAASDNQDKLQNVLKHLNDIEPCVFDKFGLLERKATIYMKLGQLKDASIVYRTLIKRNPDNFKYYKLLEVSLGIQGDNKLKKALYGKLEQFYPRCEPPKFIPLTFLQDKEELSKKLREYVLPQLERGVPATFSNVKPLYQRRKSKVSPLLEKIVLDYLSGLDPTQDPIPFIWTNYYLSQHFLFLKDFPKAQEYIDAALDHTPTLVEFYILKARILKHLGLMDTAAGILEEGRQLDLQDRFINCKTVKYFLRANNIDKAVEVASLFTVEASWFIVEQAEAYYRLYLDRKKKLDDLAESDKSEQIANDIKENQWLVRKYKGLALKRFNAIPKFYKQFEDDQLDFHSYCMRKGTPRAYLEMLEWGKALYTKPMYVRAMKEASKLYFQMHDDRLDVFGEKLIETSTPMEDFATEFYNNYSMQVREDERDYILDFEFNYRIGKLALCFASLNKFAKRFGTTSGLFGSMAIVLLHANDINGLLFLYRYRDDVPIGSSNLKEMIISSLSPLEPHSQNEILQYYLY 4hnx B 2.34 BS01 G4P A 1 K80 L81 D82 Y85 P88 K55 L56 D57 Y60 P63 2.3.1.88 P07347 PINIRRATINDIICMQNANLHNLPENYMMKYYMYHILSWPEASFVATTTTLDCIKLDPTYLAPGEKLVGYVLVKMNDDPDQQNEPPNGHITSLSVMRTYRRMGIAENLMRQALFALREVHQAEYVSLHVRQSNRAALHLYRDTLAFEVLSIEKSYYQDGEDAYAMKKVLKLEELQISNFTHRKLEDDLESDLLEDIIKQGVNDIIVEQKLISE 4imm A 2.33 BS01 CA A 1 V196 G198 D249 D251 V135 G137 D188 D190 D5VCM9 VLTQVSSIRLDQDLQIAPLADGMIAASRSGIVSGYMGESIAWQYNAEDVITGGVGIDDQGSVAVIGTRSGKLIALDARTGAARWVVELASSSLAPALISGDKVIVITNSGTIFGLDINSGATVWQYATQVPNTSVRGMAKPLALDARTVLIGGADGRIHALDTMTGAPVWTRRVGLAMGSGEIDQLRDIDGTPTVVDHYLYAASYSGQLAGFDMTTGRTMFVSELSSTKKLTTLADAVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNPVTIGTYIAVGDADGVVHILNHQGQIISRANTKGALTNLTVINNRLYAQSADGVVTVWQF 4imm A 2.33 BS02 MG A 1 V196 R197 G198 D251 T289 V135 R136 G137 D190 T228 D5VCM9 VLTQVSSIRLDQDLQIAPLADGMIAASRSGIVSGYMGESIAWQYNAEDVITGGVGIDDQGSVAVIGTRSGKLIALDARTGAARWVVELASSSLAPALISGDKVIVITNSGTIFGLDINSGATVWQYATQVPNTSVRGMAKPLALDARTVLIGGADGRIHALDTMTGAPVWTRRVGLAMGSGEIDQLRDIDGTPTVVDHYLYAASYSGQLAGFDMTTGRTMFVSELSSTKKLTTLADAVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNPVTIGTYIAVGDADGVVHILNHQGQIISRANTKGALTNLTVINNRLYAQSADGVVTVWQF 4imm B 2.33 BS01 CA B 1 T304 D305 G306 Y327 R328 G329 T228 D229 G230 Y251 R252 G253 D5VCM9 AVLTQVSSIRLDQDLQIAPLADGMIAASRSGIVSGYMGSIAWQYNAEDVITGGVGIDDQGSVAVIGTRSGKLIALDARTGAARWVVELASSSLAPALISGDKVIVITNSGTIFGLDINSGATVWQYATVRGMAKPLALDARTVLIGGADGRIHALDTMTGAPVWTRRVGLLRDIDGTPTVVDHYLYAASYSGQLAGFDMTTGRTMFVSELSSTKKLTTLADAVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNPVTIGTYIAVGDADGVVHILNHQGQIISRANTKGALTNLTVINNRLYAQSADGVVTVWQFKHHHHH 4j7f A 1.59 BS01 III B 1 Y245 H252 V255 D256 R258 W260 N263 G264 T266 L267 S268 D270 Y305 K317 F335 Y337 E348 Y129 H136 V139 D140 R142 W144 N147 G148 T150 L151 S152 D154 Y189 K201 F219 Y221 E227 2.1.1.43 Q8WTS6 GVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAFGYDHSPPEAPEWYQVELKAFQA 4j7f A 1.59 BS02 SAH A 1 A226 E228 G264 N265 H293 K294 N296 H297 F335 W352 A110 E112 G148 N149 H177 K178 N180 H181 F219 W231 2.1.1.43 Q8WTS6 GVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAFGYDHSPPEAPEWYQVELKAFQA 4jch A 1.70 BS01 1KG A 1 F13 L24 L27 F42 Q96 Y97 R100 E107 K109 P110 N165 F171 Q181 I206 P211 F15 L26 L29 F44 Q98 Y99 R102 E109 K111 P112 N167 F173 Q183 I208 P213 P35844 MDPSQYASSSSWTSFLKSIASFNGDLSSLSAPPFILSPISLTEFSQYWAEHPELFLEPSFINDDNYKEHCLIDPEVESPELARMLAVTKWFISTLKSQYCSRNESLGSEKKPLNPFLGELFVGKWENKEHPEFGETVLLSEQVSHHPPVTAFSIFNDKNKVKLQGYNQIKASFTKSLMLTVKQFGHTMLDIKDESYLVTPPPLHIEGILVASPFVELEGKSYIQSSTGLLCVIEFSGRGYFSGKKNSFKARIYKDSKDSKDKEKALYTISGQWSGSSKIIKANKKEESRLFYDAARIPAEHLNVKPLEEQHPLESRKAWYDVAGAIKLGDFNLIAKTKTELEETQRELRKEEEAKGISWQRRWFKDFDYSVTPEEGALVPEKDDTFLKLASALNLSTKNAPSGTLVGDKEDRKEDLSSIHWRFQRELWDEEKEIVL 4jch B 1.70 BS01 1KG B 1 F13 L24 F42 Q96 Y97 R100 E107 K109 P110 N165 F171 L177 V179 Q181 I203 I206 P211 F15 L26 F44 Q98 Y99 R102 E109 K111 P112 N167 F173 L179 V181 Q183 I205 I208 P213 P35844 MDPSQYASSSSWTSFLKSIASFNGDLSSLSAPPFILSPISLTEFSQYWAEHPELFLEPSFINDDNYKEHCLIDPEVESPELARMLAVTKWFISTLKSQYCSRNESLGSEKKPLNPFLGELFVGKWENKEHPEFGETVLLSEQVSHHPPVTAFSIFNDKNKVKLQGYNQIKASFTKSLMLTVKQFGHTMLDIKDESYLVTPPPLHIEGILVASPFVELEGKSYIQSSTGLLCVIEFSGKKNSFKARIYKDSKDSKDKEKALYTISGQWSGSSKIIKANKKEESRLFYDAARIPAEHLNVKPLEEQHPLESRKAWYDVAGAIKLGDFNLIAKTKTELEETQRELRKEEEAKGISWQRRWFKDFDYSVTPEEGALVPEKDDTFLKLASALNLSTKNAPSGTLVGDKEDRKEDLSSIHWRFQRELWDEEKEIVL 4jev A 1.67 BS01 PXG A 1 I51 S107 G108 T109 N112 F141 H142 G143 E193 E198 D226 V228 Q229 K255 R377 I45 S101 G102 T103 N106 F135 H136 G137 E187 E192 D220 V222 Q223 K249 R371 2.6.1.11,2.6.1.17 P40732 AITRATFDEVILPVYAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSNVFTNEPALRLGRKLIDATFAERVLFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPVSAMLTTQEIASAFHVGSHGSTYGGNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAELKPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKVVALE 4jew A 1.48 BS01 P00 A 1 S107 G108 T109 N112 F141 H142 G143 R144 E193 E198 D226 V228 Q229 K255 S102 G103 T104 N107 F136 H137 G138 R139 E188 E193 D221 V223 Q224 K250 2.6.1.11,2.6.1.17 P40732 TAITRATFDEVILPVYAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSNVFTNEPALRLGRKLIDATFAERVLFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPVSAMLTTQEIASAFGSTYGGNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAELKPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKVVALE 4jew A 1.48 BS02 TNF A 1 K30 K32 W37 G41 K25 K27 W32 G36 2.6.1.11,2.6.1.17 P40732 TAITRATFDEVILPVYAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSNVFTNEPALRLGRKLIDATFAERVLFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPVSAMLTTQEIASAFGSTYGGNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAELKPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKVVALE 4jew B 1.48 BS01 P00 A 1 G282 S283 T284 G267 S268 T269 2.6.1.11,2.6.1.17 P40732 VILPVYAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSNVFTNEPALRLGRKLIDATFAERVLFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPVSAMLTTQEIASAFHVGSHGSTYGGNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAELKPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKVV 4jex B 1.43 BS01 TNF B 1 L18 P19 V20 K21 R355 Y359 L1 P2 V3 K4 R333 Y337 2.6.1.11,2.6.1.17 P40732 LPVKAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSNVFTNEPALRLGRKLIDATFAERVLFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPVSAMLTTQEIASAFGSTYGGNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAELKPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKVVA 4jex B 1.43 BS02 P00 B 1 S107 G108 T109 N112 F141 H142 R144 E193 D226 V228 Q229 K255 S90 G91 T92 N95 F124 H125 R127 E176 D209 V211 Q212 K238 2.6.1.11,2.6.1.17 P40732 LPVKAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSNVFTNEPALRLGRKLIDATFAERVLFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPVSAMLTTQEIASAFGSTYGGNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAELKPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKVVA 4jqc A 2.80 BS01 NAD A 1 G13 A15 I20 Q40 L44 C63 D64 V65 S91 I92 I119 L144 S145 K163 A189 G190 I192 T194 L195 A196 G13 A15 I20 Q40 L44 C63 D64 V65 S91 I92 I119 L144 S145 K163 A189 G190 I192 T194 L195 A196 1.3.1.9 P0AEK4 MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 4jqc A 2.80 BS02 0WE A 1 F94 A95 G97 L100 Y146 N155 Y156 A196 S198 I200 F94 A95 G97 L100 Y146 N155 Y156 A196 S198 I200 1.3.1.9 P0AEK4 MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 4jqc B 2.80 BS01 NAD B 1 G13 S19 I20 Q40 L44 C63 D64 V65 S91 I92 G93 I119 S145 K163 A189 G190 I192 T194 L195 A196 G12 S18 I19 Q39 L43 C62 D63 V64 S90 I91 G92 I118 S144 K162 A188 G189 I191 T193 L194 A195 1.3.1.9 P0AEK4 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 4jqc B 2.80 BS02 0WE B 1 F94 A95 L100 Y146 P154 N155 Y156 S198 G199 F93 A94 L99 Y145 P153 N154 Y155 S196 G197 1.3.1.9 P0AEK4 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 4jr8 A 2.30 BS01 RET A 1 Y81 W84 T88 M116 G120 W142 S145 T146 W186 Y189 P190 W193 A219 K220 Y78 W81 T85 M113 G117 W139 S142 T143 W183 Y186 P187 W190 A216 K217 P94854 PEGEAIWLWLGTAGMFLGMLYFIARGWGETDSRRQKFYIATILITAIAFVNYLAMALGFGLTIVEIAGEQRPIYWARYSDWLFTTPLLLYDLGLLAGADRNTISSLVSLDVLMIGTGLVATLSAGSGVLSAGAERLVWWGISTAFLLVLLYFLFSSLSGRVADLPSDTRSTFKTLRNLVTVVWLVYPVWWLVGTEGIGLVGIGIETAGFMVIDLVAKVGFGIILLRSHGVLDGA 4jr8 A 2.30 BS02 22B A 1 N104 T105 L112 G143 A147 F148 F155 S159 N101 T102 L109 G140 A144 F145 F152 S156 P94854 PEGEAIWLWLGTAGMFLGMLYFIARGWGETDSRRQKFYIATILITAIAFVNYLAMALGFGLTIVEIAGEQRPIYWARYSDWLFTTPLLLYDLGLLAGADRNTISSLVSLDVLMIGTGLVATLSAGSGVLSAGAERLVWWGISTAFLLVLLYFLFSSLSGRVADLPSDTRSTFKTLRNLVTVVWLVYPVWWLVGTEGIGLVGIGIETAGFMVIDLVAKVGFGIILLRSHGVLDGA 4js3 A 2.00 BS02 JS3 A 1 Y38 M43 A59 F62 T63 L67 L68 P364 Y7 M12 A28 F31 T32 L36 L37 P333 1.3.5.2 Q02127 TGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR 4js8 A 1.94 BS01 1PF A 1 I531 V539 A551 I586 M602 E603 C604 G605 I607 D608 S611 L654 I663 P673 T675 I17 V25 A37 I72 M88 E89 C90 G91 I93 D94 S97 L140 I149 P159 T161 2.7.12.1 P33981 NECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTVGTVNYMPPEAIKDMSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQI 4jt3 A 2.20 BS01 1PH A 1 I531 G532 S533 G534 S537 V539 Q541 A551 K553 M602 E603 C604 G605 N606 L654 I663 I17 G18 S19 G20 S23 V25 Q27 A37 K39 M88 E89 C90 G91 N92 L140 I149 2.7.12.1 P33981 NECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMGTVNYMPPEAIKDMSPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQ 4jts A 2.21 BS02 JTS A 1 Y38 M43 A59 F62 T63 L67 L68 P69 P364 Y7 M12 A28 F31 T32 L36 L37 P38 P333 1.3.5.2 Q02127 TGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR 4jtu A 1.90 BS02 JTU A 1 M43 Q47 P52 A55 H56 A59 T63 L68 V134 R136 Y356 T360 P364 M12 Q16 P21 A24 H25 A28 T32 L37 V103 R105 Y325 T329 P333 1.3.5.2 Q02127 TGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR 4k8b A 2.80 BS01 III C 1 I3 T4 A5 Y6 S7 Q8 T10 R11 C16 T19 S20 G23 Q28 E30 E32 V33 Q34 V35 V36 S37 T63 L64 A65 P88 V107 T108 R109 I1 T2 A3 Y4 S5 Q6 T8 R9 C14 T17 S18 G21 Q26 E28 E30 V31 Q32 V33 V34 S35 T61 L62 A63 P86 V105 T106 R107 3.4.21.98 Q0ZNA6 24144444 ITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTM 4k8b A 2.80 BS03 1RR A 1 Y56 H57 V78 D79 D81 R123 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 V158 C159 D168 Y54 H55 V76 D77 D79 R121 V130 L133 K134 G135 S136 S137 F152 R153 A154 A155 V156 C157 D166 3.4.21.98 Q0ZNA6 24144444 ITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTM 4k8b B 2.80 BS01 III D 1 I3 T4 A5 Y6 S7 Q8 T10 R11 C16 T19 S20 Q28 E30 V33 Q34 V35 V36 S37 K62 T63 L64 A65 P88 V107 R109 I1 T2 A3 Y4 S5 Q6 T8 R9 C14 T17 S18 Q26 E28 V31 Q32 V33 V34 S35 K60 T61 L62 A63 P86 V105 R107 3.4.21.98 Q0ZNA6 24144444 ITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTM 4k8b B 2.80 BS03 1RR B 1 Y56 H57 D79 D81 R123 V132 L135 K136 G137 S138 S139 F154 R155 A156 A157 V158 C159 Y54 H55 D77 D79 R121 V130 L133 K134 G135 S136 S137 F152 R153 A154 A155 V156 C157 3.4.21.98 Q0ZNA6 24144444 ITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTM 4kas C 1.85 BS03 DU C 1 F77 E86 R147 F75 E84 R145 2.1.1.148 Q9WYT0 24563811 HMKIDILDKGFVELVDVMGNDLSAVRAARVSFDKDEERDRHLIEYLMKHGDETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEVQV 4kat A 2.14 BS02 FDA A 1 R78 H79 R80 I81 N169 L173 H178 A179 R80 H81 R82 I83 N171 L175 H180 A181 2.1.1.148 Q9WYT0 24563811 HHMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLKADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILK 4kat A 2.14 BS05 DU D 1 Q75 R78 K174 Q77 R80 K176 2.1.1.148 Q9WYT0 24563811 HHMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLKADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILK 4kat C 2.14 BS02 DU B 1 Q75 R78 Q70 R73 2.1.1.148 Q9WYT0 24563811 MKIDILDKGFVELVDVMGNDLSAVRAARVSKDEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLKADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEV 4kat D 2.14 BS01 DU A 1 R74 Q75 R78 R69 Q70 R73 2.1.1.148 Q9WYT0 24563811 HMKIDILDKGFVELVDVMGNDLSAVRAARVSFEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYYEFYIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLKADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEV 4kgc A 2.69 BS01 NUC I 1 H39 R40 R42 P43 T45 R63 R72 R83 F84 Q85 S86 R116 V117 T118 M120 H2 R3 R5 P6 T8 R26 R35 R46 F47 Q48 S49 R79 V80 T81 M83 P84233 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 4kgc C 2.69 BS03 HRU C 1 N38 E41 N25 E28 Q6AZJ8 AKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPKK 4kgc G 2.69 BS02 NUC J 1 A14 K15 R17 R20 G28 R32 R42 R77 A1 K2 R4 R7 G15 R19 R29 R64 Q6AZJ8 AKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPKK 4kmg A 1.40 BS01 HEM A 1 H13 C14 C17 H18 N23 I25 R26 K29 N30 L31 T35 Q39 L41 I50 A51 I55 G56 Q57 M58 Y61 I77 H13 C14 C17 H18 N23 I25 R26 K29 N30 L31 T35 Q39 L41 I50 A51 I55 G56 Q57 M58 Y61 I77 Q7U624 24216109 ETSGEGAVLFGQHCAGCHVNGGNIIRRGKNLKLATLKRQGLDSTEAIASIARKGIGQMSGYGDKLGEGGDQLVAGWILEQAQNAWTQG 4l0y B 2.50 BS02 NUC D 1 P334 Y386 R391 R394 Y395 Y397 K404 R409 Y410 P1 Y53 R58 R61 Y62 Y64 K71 R76 Y77 P14921 PIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKP 4l0z A 2.70 BS01 NUC C 1 R139 R142 G143 K167 T169 V170 D171 R177 R86 R89 G90 K114 T116 V117 D118 R124 Q03347 VLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRGSLSFSERLSELEQLRRTAMRVS 4l18 E 2.30 BS01 NUC G 1 R139 R142 G143 K167 V170 D171 R88 R91 G92 K116 V119 D120 Q03347 VEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRGSLSFSERLSELEQL 4l48 A 2.10 BS01 CE6 A 1 A19 G21 N22 K115 E116 G117 W121 W122 Y153 A19 G21 N22 K115 E116 G117 W121 W122 Y153 3.2.1.4 A5CLK3 MTTHGRATHYSLGQGNTIANGNCSMPAVPADRMYVAVSSPEYSGAAACGTFLDVTGPKGTVRVQVADQCHGCEVGHLNLSEEAFRALGDFNAGIIPISYVTVRDPAGPTVAIRVKEGSSRWWAGLQVLNAGNRIDRVEIQAGRQWLPLTRTDYGYWVTPSPIQDGPLTVKVTDQYGRAVVLPGLRMAPGEIQRTASRFYPVH 4l48 C 2.10 BS01 CE6 C 1 A19 G21 N22 S24 K115 E116 G117 S119 W121 W122 Y153 A19 G21 N22 S24 K115 E116 G117 S119 W121 W122 Y153 3.2.1.4 A5CLK3 MTTHGRATHYSLGQGNTIANGNCSMPAVPADRMYVAVSSPEYSGAAACGTFLDVTGPKGTVRVQVADQCHGCEVGHLNLSEEAFRALGDFNAGIIPISYVTVRDPAGPTVAIRVKEGSSRWWAGLQVLNAGNRIDRVEIQAGRQWLPLTRTDYGYWVTPSPIQDGPLTVKVTDQYGRAVVLPGLRMAPGEIQRTASRFYPVH 4lkt A 2.57 BS01 EIC A 1 M23 L26 L32 M35 L60 K61 R109 R129 Y131 M25 L28 L34 M37 L62 K63 R111 R131 Y133 Q01469 NAMATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKVE 4lkt B 2.57 BS01 EIC B 1 M23 L26 L32 M35 L60 K61 A78 D79 R109 C120 R129 Y131 M24 L27 L33 M36 L61 K62 A79 D80 R110 C121 R130 Y132 Q01469 AMATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKV 4lkt C 2.57 BS01 EIC C 1 Y22 M23 L32 G36 P41 T56 A78 D79 V118 C120 R129 Y131 Y23 M24 L33 G37 P42 T57 A79 D80 V119 C121 R130 Y132 Q01469 AMATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKVE 4lkt D 2.57 BS01 EIC D 1 M23 L32 G36 T56 D79 I107 V118 C120 R129 Y131 M25 L34 G38 T58 D81 I109 V120 C122 R131 Y133 Q01469 NAMATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKVE 4lvq A 2.30 BS01 PO4 A 1 S56 T57 A58 G85 S86 D104 R187 S191 G192 T193 S7 T8 A9 G36 S37 D55 R138 S142 G143 T144 P0A5Y2 TLKASGSTAQANAMTRFVNVFEQACPGQTLNYTANGSGAGISEFNGNQTDFGGSDVPLSKDEAAAAQRRCGSPAWNLPVVFGPIAVTYNLNSVSSLNLDGPTLAKIFNGSITQWNNPAIQALNRDFTLPGERIHVVFRSDESGTTDNFQRYLQAASNGAWGKGAGKSFQGGVGEGARGNDGTSAAAKNTPGSITYNEWSFAQAQHLTMANIVTSAGGDPVAITIDSVGQTIAGATISGVGNDLVLDTDSFYRPKRPGSYPIVLATYEIVCSKYPDSQVGTAVKAFLQSTIGAGQSGLGDNGYIPIPDEFKSRLSTAVNA 4m58 A 3.21 BS01 NI A 1 M1 H2 H67 M113 M1 H2 H67 M113 Q8R9C0 24366337 MHIPEGYLSPQTCAVMGAAMVPVLTVAAKKVNKSFDKKDVPAMAIGSAFAFTIMMFNVPIPGGTTAHAIGATLLATTLGPWAASISLTLALFIQALLFGDGGILALGANSFNMAFIAPFVGYGIYRLMLSLKLNKVLSSAIGGYVGINAAALATAIELGLQPLLFHTANGTPLYFPYGLNVAIPAMMFAHLTVAGIVEAVITGLVVYYLQKVDEENILHKFSYRLRG 4m5b A 1.83 BS01 NI A 1 M1 H2 T65 H67 M113 M1 H2 T65 H67 M113 Q8R9C0 24366337 MHIPEGYLSPQTCAVMGAAMVPVLTVAAKKVNKSFDKKDVPAMAIGSAFAFTIMMFNVPIPGGTTAHAIGATLLATTLGPWAASISLTLALFIQALLFGDGGILALGANSFNMAFIAPFVGYGIYRLMLSLKLNKVLSSAIGGYVGINAAALATAIELGLQPLLFHTANGTPLYFPYGLNVAIPAMMFAHLTVAGIVEAVITGLVVYYLLEHHH 4m7k H 1.90 BS01 CA H 1 E10 K19 E10 K19 EVHLQQSGAELMKPGASVKISCKASGYTFITYWIEWVKQRPGHGLEWIGDILPGSGSTNYNENFKGKATFTADSSSNTAYMQLSSLTSEDSAVYYCARSGYYGNSGFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH 4m91 A 1.10 BS01 III B 1 A51 R56 Q57 C58 S59 Y92 N105 S106 A107 A50 R55 Q56 C57 S58 Y91 N104 S105 A106 Q13454 SKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVSRQANEEYQILANSWRYSSAFSNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRL 4m92 A 1.60 BS01 III B 1 A51 R56 C58 Y92 D93 T96 F99 N105 S106 A107 A51 R56 C58 Y92 D93 T96 F99 N105 S106 A107 Q13454 ASKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVSRQANEEYQILANSWRYSSAFSNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFR 4mkf B 1.70 BS03 CA B 1 K40 E42 K40 E42 2.7.4.3 P16304 24615904 MNLVLMGLPGAGKGTQGEKIVEDYGIPHISTGDMFRAAMKEETPLGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEEYGKPIDYVINIEVRKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQRADDNEETVSKRLEVNMKQMQPLLDFYSEKGYLANVNGEQDIEDVYADVKDLLGGLKK 4mkg A 1.45 BS02 AP5 A 1 P9 G10 A11 G12 K13 G14 T15 T31 G32 F35 R36 I53 E57 V59 T64 G85 F86 R88 Q92 R123 L124 R127 T136 Y137 H138 F141 R160 R171 Q199 I201 P9 G10 A11 G12 K13 G14 T15 T31 G32 F35 R36 I53 E57 V59 T64 G85 F86 R88 Q92 R123 L124 R127 T136 Y137 H138 F141 R160 R171 Q199 I201 2.7.4.3 P16304 24615904 MNIVLMGLPGAGKGTQAERIVEKYGIPHISTGDMFRAAMKEETPLGLEAKSYIDKGELVPDEVTIGIVRERLSKSDCERGFLLDGFPRTVAQAEALEEILEEMGRPIDYVINIQVDKEELMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQRADDNEETVTKRLEVNMKQTAPLLAFYDSKEVLVNVNGQQDIQDVFADVKVILGGLKQ 4mkh A 1.50 BS02 AP5 A 1 P9 G10 A11 G12 K13 G14 T15 T31 G32 F35 R36 I53 E57 L58 V59 T64 G85 F86 R88 Q92 R123 L124 R127 H138 F141 R171 R199 I201 P10 G11 A12 G13 K14 G15 T16 T32 G33 F36 R37 I54 E58 L59 V60 T65 G86 F87 R89 Q93 R124 L125 R128 H139 F142 R172 R200 I202 2.7.4.3 P16304 24615904 GMNIVLMGLPGAGKGTLAEKIVEKYGIPHISTGDMFRAAMKEETPLGLEAKSYIDKGELVPDEVTIGIVRERLSKSDCERGFLLDGFPRTVAQAEALEEILEEMGRPIDYVINIQVRKEELMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQRADDNEETVTKRLEVNMKQMAPLLAFYDSKEVLVNVNGERDIEDVFADVDVILLEHHH 4mmx A 3.32 BS02 MN A 2 D284 N286 D288 Y290 A291 D292 D284 N286 D288 Y290 A291 D292 P06756 FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKIDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQ 4mmx B 3.32 BS01 MN B 1 D119 S121 S123 E220 D119 S121 S123 E220 P05106 GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKG 4mmx B 3.32 BS02 MN B 2 S123 D126 D127 D251 S123 D126 D127 D251 P05106 GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKG 4mmx B 3.32 BS03 MN B 3 D158 N215 D217 A218 P219 E220 D158 N215 D217 A218 P219 E220 P05106 GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKG 4mmy A 3.18 BS01 III C 1 D150 Y178 Q180 A215 D218 D150 Y178 Q180 A215 D218 P06756 FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKIDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQ 4mmy A 3.18 BS04 MN A 3 D349 D351 D353 F355 D357 D349 D351 D353 F355 D357 P06756 FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKIDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQ 4mmy B 3.18 BS01 III C 1 S121 Y122 S123 D126 M180 R214 N215 R216 A218 S121 Y122 S123 D126 M180 R214 N215 R216 A218 P05106 GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKG 4mmy B 3.18 BS03 MN B 2 S123 M124 D126 D127 D251 S123 M124 D126 D127 D251 P05106 GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKG 4mmz A 3.10 BS05 MN A 5 C596 D599 V601 E636 C596 D599 V601 E636 P06756 FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWG 4mmz B 3.10 BS03 MN B 3 D158 N215 D217 A218 P219 E220 H255 D158 N215 D217 A218 P219 E220 H255 P05106 GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKG 4mp0 C 2.10 BS01 III D 1 P24 Q68 Y70 D71 R74 Y78 R96 G97 I133 Y134 I169 D242 Y255 F257 R261 P270 N271 C273 G274 E275 T288 L289 M290 C291 S292 F293 Q294 I295 L296 K297 P18 Q62 Y64 D65 R68 Y72 R90 G91 I127 Y128 I163 D236 Y249 F251 R255 P264 N265 C267 G268 E269 T282 L283 M284 C285 S286 F287 Q288 I289 L290 K291 3.1.3.16 P62136 24591642 LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK 4mtu A 0.97 BS01 ZN A 1 D45 H142 D45 H142 Q6KC22 MVGKKVVHHLMMSAKDAHYTGNLVNGARIVNQWGDVGTELMVYVDGDISLFLGYKDIEFTAPVYVGDFMEYHGWIEKVGNQSYTCKFEAWKVAKMVDITNPQDTRATACEPPVLCGTATGSLFIAKDNQRGPQESSFKDAKHP 4myh B 3.38 BS01 GSH B 1 R280 R284 N343 S394 R183 R187 N246 S297 3.6.3.44 P40416 24604199 YIWPKGNNKVRIRVLIALGLLISAKILNVQVPFFFKQTIDSMNIAWDDPTVALPAAIGLTILCYGVARFGSVLFGELRNAVFAKVAQNAIRTVSLQTFQHLMKLDLGWHLSRQTGGLTRAMDRGTKGISQVLTAMVFHIIPISFEISVVCGILTYQFGASFAAITFSTMLLYSIFTIKTTAWRTHFRRDANKADNKAASVALDSLINFEAVKYFNNEKYLADKYNGSLMNYRDSQIKVSQSLAFLNSGQNLIFTTALTAMMYMGCTGVIGGNLTVGDLVLINQLVFQLSVPLNFLGSVYRDLKQSLIDMETLFKLRKNEVKIKNAERPLMLPENVPYDITFENVTFGYHPDRKILKNASFTIPAGWKTAIVGSSGSGKSTILKLVFRFYDPESGRILINGRDIKEYDIDALRKVIGVVPQDTPLFNDTIWENVKFGRIDATDEEVITVVEKAQLAPLIKKLPQGFDTIVGERGLMISGGEKQRLAIARVLLKNARIMFFDEATSALDTHTEQALLRTIRDNFTSGSRTSVYIAHRLRTIADADKIIVLDNGRVREEGKHLELLAMPGSLYRELWTIQEDLDHLENELKDQQELWSHPQ 4mzf B 2.10 BS01 III A 1 W62 E64 W72 Y91 G93 D95 Y98 M140 F141 E142 W151 Y170 D173 Y177 Y179 Q180 D184 D189 D249 D250 F251 W24 E26 W34 Y53 G55 D57 Y60 M102 F103 E104 W113 Y132 D135 Y139 Y141 Q142 D146 D151 D193 D194 F195 Q9Y657 24589551 GSSHHHHHHGSRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLV 4mzg B 1.70 BS01 III A 1 W72 G93 F94 D95 M140 F141 E142 W151 Y170 D173 Y177 Y179 Q180 D184 D189 W25 G46 F47 D48 M93 F94 E95 W104 Y123 D126 Y130 Y132 Q133 D137 D142 Q9Y657 24589551 SMRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLV 4mzh A 2.20 BS01 III B 1 G93 D95 M140 F141 E142 W151 Y170 D173 Y177 Y179 Q180 D184 D189 G54 D56 M101 F102 E103 W112 Y131 D134 Y138 Y140 Q141 D145 D150 Q9Y657 24589551 SSHHHHHHGSRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMSLVGKQVEYAKGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLV 4mzq A 1.59 BS01 1VU A 1 L50 F51 L52 G79 N80 Q81 S82 S121 F123 L50 F51 L52 G79 N80 Q81 S82 S121 F123 Q6KC22 MVGKKVVHHLMMSAKDAHYTGNLVNGARIVNQWGDVGTELMVYVDGDISLFLGYKDIEFTAPVYVGDFMEYHGWIEKVGNQSYTCKFEAWKVAKMVDITNPQDTRATACEPPVLCGTATGSLFIAKDNQRGPQESSFKDAKHP 4mzq A 1.59 BS02 1VU F 1 V24 G26 E58 F59 T60 A61 P62 V24 G26 E58 F59 T60 A61 P62 Q6KC22 MVGKKVVHHLMMSAKDAHYTGNLVNGARIVNQWGDVGTELMVYVDGDISLFLGYKDIEFTAPVYVGDFMEYHGWIEKVGNQSYTCKFEAWKVAKMVDITNPQDTRATACEPPVLCGTATGSLFIAKDNQRGPQESSFKDAKHP 4mzq C 1.59 BS01 1VU C 1 L50 F51 L52 G79 N80 Q81 S82 S121 L50 F51 L52 G79 N80 Q81 S82 S121 Q6KC22 MVGKKVVHHLMMSAKDAHYTGNLVNGARIVNQWGDVGTELMVYVDGDISLFLGYKDIEFTAPVYVGDFMEYHGWIEKVGNQSYTCKFEAWKVAKMVDITNPQDTRATACEPPVLCGTATGSLFIAKDNQRGPQESSFKDAKHP 4mzq C 1.59 BS02 1VU D 1 Y19 G26 E58 F59 T60 A61 P62 Y19 G26 E58 F59 T60 A61 P62 Q6KC22 MVGKKVVHHLMMSAKDAHYTGNLVNGARIVNQWGDVGTELMVYVDGDISLFLGYKDIEFTAPVYVGDFMEYHGWIEKVGNQSYTCKFEAWKVAKMVDITNPQDTRATACEPPVLCGTATGSLFIAKDNQRGPQESSFKDAKHP 4mzq H 1.59 BS02 1VU K 1 G26 E58 F59 T60 A61 P62 G26 E58 F59 T60 A61 P62 Q6KC22 MVGKKVVHHLMMSAKDAHYTGNLVNGARIVNQWGDVGTELMVYVDGDISLFLGYKDIEFTAPVYVGDFMEYHGWIEKVGNQSYTCKFEAWKVAKMVDITNPQDTRATACEPPVLCGTATGSLFIAKDNQRGPQESSFKDAKHP 4nba B 2.10 BS03 9CA B 1 G178 A259 L270 V272 F275 Q282 E284 F329 N330 G177 A258 L269 V271 F274 Q281 E283 F328 N329 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDVSIWLPGVLKVNPFPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSGLEHHH 4nba D 2.10 BS01 FES D 1 C46 H48 G49 C65 F67 H68 G70 C84 C43 H45 G46 C62 F64 H65 G67 C81 1.14.12.22 Q8GI16 24584240 IWLKVCAASDMQPGTIRRVNRVGAAPLAVYRVGDQFYATEDTCTHGIASLSEGTLDGDVIECPFHGGAFNVCTGMPASSPCTVPLGVFEVEVKEGEVYVAGEKK 4nbb C 2.05 BS04 9CA C 1 G178 H183 A259 V262 L270 V272 F275 Q282 F329 N330 G177 H182 A258 V261 L269 V271 F274 Q281 F328 N329 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDVSIWLPGVLKVNPFPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSGLEHHH 4nbd A 1.95 BS03 9CA A 1 G178 H183 I184 A259 I262 L270 W275 E284 F329 N330 G177 H182 I183 A258 I261 L269 W274 E283 F328 N329 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPWPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSGL 4nbd B 1.95 BS03 9CA B 1 G178 H183 I184 I262 L270 V272 W275 Q282 E284 F329 N330 G177 H182 I183 I261 L269 V271 W274 Q281 E283 F328 N329 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPWPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSGL 4nbe A 2.10 BS03 9FL A 1 G178 I184 A259 I262 L270 V272 W275 E284 F329 N330 G177 I183 A258 I261 L269 V271 W274 E283 F328 N329 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPWPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSG 4nbe B 2.10 BS02 FES B 1 C69 H71 R72 V74 C90 Y92 H93 W95 C68 H70 R71 V73 C89 Y91 H92 W94 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPWPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSGLE 4nbe C 2.10 BS01 FE2 C 1 N177 H183 H187 D333 N176 H182 H186 D332 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPWPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSGLEHHH 4nbe C 2.10 BS03 9FL C 1 G178 H183 I184 A259 L270 V272 W275 E284 F329 N330 G177 H182 I183 A258 L269 V271 W274 E283 F328 N329 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPWPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSGLEHHH 4nbh B 2.15 BS03 9CA B 1 G178 H183 A259 I262 L270 F275 Y282 F329 G177 H182 A258 I261 L269 F274 Y281 F328 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPFPNPDMMYFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSGLEHHHHH 4nbh C 2.15 BS03 9CA C 1 G178 I184 L200 A259 I262 L270 V272 F275 F329 N330 G177 I183 L199 A258 I261 L269 V271 F274 F328 N329 1.14.12.22 Q84II6 24584240 ANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEINEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPFPNPDMMYFEWYVPIDENTHYYFQTLGKPCANDEERKKYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQTQAHVSGLEHHH 4nm0 A 2.50 BS01 III B 1 V263 D264 L266 I270 Y288 F291 K292 F293 P294 Q295 I296 V235 D236 L238 I242 Y260 F263 K264 F265 P266 Q267 I268 2.7.11.26,2.7.11.1 P49841 MKVSRDSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARH 4nm0 A 2.50 BS02 MG A 1 K183 N186 D200 K155 N158 D172 2.7.11.26,2.7.11.1 P49841 MKVSRDSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARH 4nm0 A 2.50 BS03 ADP A 1 F67 A83 K85 V110 L132 D133 Y134 V135 T138 R141 N186 L188 D200 F39 A55 K57 V82 L104 D105 Y106 V107 T110 R113 N158 L160 D172 2.7.11.26,2.7.11.1 P49841 MKVSRDSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARH 4nm3 A 2.10 BS03 MG A 2 D200 G202 D174 G176 2.7.11.26,2.7.11.1 P49841 RTTSFMKVSRSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARH 4nm3 A 2.10 BS04 ADP A 1 F67 V70 A83 K85 V110 D133 Y134 V135 T138 R141 Q185 N186 L188 D200 F43 V46 A59 K61 V86 D107 Y108 V109 T112 R115 Q159 N160 L162 D174 2.7.11.26,2.7.11.1 P49841 RTTSFMKVSRSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARH 4nm5 A 2.30 BS02 III C 1 R92 F93 K94 R96 R180 G202 K205 N213 V214 Y216 I217 C218 R69 F70 K71 R73 R157 G179 K182 N190 V191 Y193 I194 C195 2.7.11.26 Q6FI27 GSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARH 4nm5 A 2.30 BS05 MG A 2 K85 D200 G202 K62 D177 G179 2.7.11.26 Q6FI27 GSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARH 4nm7 A 2.30 BS02 III C 1 K91 R92 F93 K94 R96 R180 G202 K205 N213 V214 I217 C218 R223 K64 R65 F66 K67 R69 R151 G173 K176 N184 V185 I188 C189 R194 2.7.11.26 Q6FI27 SMKVSRDSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARH 4nmh A 2.90 BS01 2KG A 1 I121 T124 S170 Y177 V180 Y183 L215 G216 L217 I227 I231 A233 I97 T100 S146 Y153 V156 Y159 L191 G192 L193 I203 I207 A209 1.1.1.146 P50172 EEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKVTYPMVAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF 4nmh A 2.90 BS02 NDP A 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 I168 S169 S170 Y183 K187 L215 G216 L217 I218 T220 T222 A223 G17 S19 K20 G21 I22 A41 R42 S43 T68 M69 N95 I97 I144 S145 S146 Y159 K163 L191 G192 L193 I194 T196 T198 A199 1.1.1.146 P50172 EEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKVTYPMVAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF 4nmh B 2.90 BS01 2KG B 1 I121 T124 S170 Y177 Y183 L215 G216 L217 T222 A223 I227 I231 A233 I96 T99 S145 Y152 Y158 L190 G191 L192 T197 A198 I202 I206 A208 1.1.1.146 P50172 EFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKVTYPMVAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF 4nmh D 2.90 BS01 2KG D 1 I121 T124 S170 Y177 Y183 L215 G216 L217 A223 E226 I227 I231 A233 I96 T99 S145 Y152 Y158 L190 G191 L192 A198 E201 I202 I206 A208 1.1.1.146 P50172 EFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKVTYPMVAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF 4nst A 2.20 BS01 ADP A 1 I733 E735 G736 T737 A754 K756 F813 E814 Y815 M816 D819 S863 N864 L866 D877 H1040 I18 E20 G21 T22 A39 K41 F90 E91 Y92 M93 D96 S140 N141 L143 D154 H317 2.7.11.22,2.7.11.23 Q9NYV4 ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKK 4nst A 2.20 BS02 AF3 A 1 D859 K861 N864 D877 D136 K138 N141 D154 2.7.11.22,2.7.11.23 Q9NYV4 ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKK 4nst A 2.20 BS03 MG A 1 N864 D877 N141 D154 2.7.11.22,2.7.11.23 Q9NYV4 ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKK 4nst A 2.20 BS04 MG A 2 H999 S1017 H276 S294 2.7.11.22,2.7.11.23 Q9NYV4 ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKK 4nst C 2.20 BS02 AF3 C 1 D859 K861 D877 D133 K135 D151 2.7.11.22,2.7.11.23 Q9NYV4 SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSK 4nst D 2.20 BS01 MG D 1 Q37 L41 Q17 L21 O75909 KPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQG 4ntj A 2.62 BS01 AZJ A 1 V102 Y105 F106 Y109 S156 N159 V190 N191 C194 F252 R256 Y259 L276 K280 V83 Y86 F87 Y90 S134 N137 V152 N153 C156 F309 R313 Y316 L333 K337 Q9H244 LCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTKNLLGAKILSVVIWAFMFLLSLPNMILKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLRGVGKVRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLNPFIYFFLCKSFRNSLISM 4ntj A 2.62 BS02 CLR A 1 I23 L27 Y278 S282 W285 I8 L12 Y335 S339 W342 Q9H244 LCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTKNLLGAKILSVVIWAFMFLLSLPNMILKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLRGVGKVRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLNPFIYFFLCKSFRNSLISM 4ntj A 2.62 BS03 CLR A 2 I120 I200 L203 I204 V207 I101 I162 L165 I166 V169 Q9H244 LCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTKNLLGAKILSVVIWAFMFLLSLPNMILKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLRGVGKVRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLNPFIYFFLCKSFRNSLISM 4nu1 A 2.50 BS01 III B 1 F229 V263 D264 L266 V267 I270 Y288 F291 K292 F293 P294 Q295 I296 F203 V237 D238 L240 V241 I244 Y262 F265 K266 F267 P268 Q269 I270 2.7.11.26,2.7.11.1 Q9WV60 RTTSFAMKVSSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 4nu1 A 2.50 BS03 MG A 2 D181 D200 D155 D174 2.7.11.26,2.7.11.1 Q9WV60 RTTSFAMKVSSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 4nu1 A 2.50 BS04 ADP A 1 G63 N64 G65 S66 F67 G68 V70 A83 K85 D133 Y134 V135 T138 Q185 N186 L188 D200 G39 N40 G41 S42 F43 G44 V46 A59 K61 D107 Y108 V109 T112 Q159 N160 L162 D174 2.7.11.26,2.7.11.1 Q9WV60 RTTSFAMKVSSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 4nu1 A 2.50 BS05 AF3 A 1 G65 S66 F67 D181 K183 N186 D200 G41 S42 F43 D155 K157 N160 D174 2.7.11.26,2.7.11.1 Q9WV60 RTTSFAMKVSSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 4nwk A 1.62 BS01 2R8 A 1 Q41 F43 H57 G58 D79 D81 I132 L135 K136 G137 S138 S139 F154 R155 A156 A157 D168 Q52 F54 H68 G69 D90 D92 I143 L146 K147 G148 S149 S150 F165 R166 A167 A168 D179 A8DG50 24555570 GSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVESLET 4nwl A 2.20 BS01 2R9 A 1 F43 Y56 H57 G58 V78 D81 R123 L135 K136 G137 S139 F154 R155 A156 A157 V158 C159 D168 F55 Y68 H69 G70 V90 D93 R135 L147 K148 G149 S151 F166 R167 A168 A169 V170 C171 D180 A8DG50 24555570 KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVESLETTMRSP 4nwl B 2.20 BS01 2R9 B 1 F43 Y56 H57 G58 V78 D79 D81 R123 I132 L135 K136 G137 S139 F154 R155 A156 A157 V158 C159 D168 F55 Y68 H69 G70 V90 D91 D93 R135 I144 L147 K148 G149 S151 F166 R167 A168 A169 V170 C171 D180 A8DG50 24555570 KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVESLETTMRSP 4o25 A 2.20 BS01 GTP A 1 R15 S16 V17 G18 K19 S20 S21 F31 V32 D33 Y35 P37 G63 N119 K120 D122 L123 S149 A150 R13 S14 V15 G16 K17 S18 S19 F29 V30 D31 Y33 P35 G61 N117 K118 D120 L121 S147 A148 Q921J2 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEK 4o25 A 2.20 BS02 MG A 1 K19 S20 D60 T61 K17 S18 D58 T59 Q921J2 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEK 4o2l A 2.40 BS01 GTP A 1 S16 V17 G18 K19 S20 S21 F31 V32 D33 Y35 P37 A63 N119 K120 D122 L123 S149 A150 K151 S14 V15 G16 K17 S18 S19 F29 V30 D31 Y33 P35 A61 N117 K118 D120 L121 S147 A148 K149 Q921J2 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAAQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEK 4o2l B 2.40 BS01 GTP B 1 R15 S16 V17 G18 K19 S20 S21 F31 V32 D33 Y35 P37 T38 A63 N119 K120 D122 L123 S149 A150 R13 S14 V15 G16 K17 S18 S19 F29 V30 D31 Y33 P35 T36 A61 N117 K118 D120 L121 S147 A148 Q921J2 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAAQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEK 4o2r A 2.25 BS01 GDP A 1 S16 V17 G18 K19 S20 S21 F31 V32 D33 Y35 N119 K120 D122 L123 S149 A150 K151 S14 V15 G16 K17 S18 S19 F29 V30 D31 Y33 N117 K118 D120 L121 S147 A148 K149 Q921J2 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAVQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEK 4o2r B 2.25 BS01 GDP B 1 S16 G18 K19 S20 S21 F31 V32 D33 N119 K120 D122 L123 S149 A150 K151 S14 G16 K17 S18 S19 F29 V30 D31 N117 K118 D120 L121 S147 A148 K149 Q921J2 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAVQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEK 4o2r B 2.25 BS02 MG B 1 K19 S20 T38 D60 T61 K17 S18 T36 D58 T59 Q921J2 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAVQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEK 4o30 A 2.10 BS01 III C 1 E212 M216 Q217 M263 Y269 I276 R279 E280 D282 S286 M287 M288 T289 K331 C332 R334 Y335 Y359 Y361 G363 Y364 E365 E367 Y368 P369 E55 M59 Q60 M106 Y112 I119 R122 E123 D125 S129 M130 M131 T132 K174 C175 R177 Y178 Y202 Y204 G206 Y207 E208 E210 Y211 P212 2.1.1.43 B9RU15 RRRLLPFVSSEDPAQRLKQMGTLASALTELQMEFSDDLTYSSGMAPRSANQARFEEGGMQVLTKEDIETLEQCRAMCKRGDCPPLLVVFDSREGFTVEADGQIKDMTFIAEYTGDVDYIRNREHDDCDSMMTLLLAKDPSKSLVICPDKRGNIARFISGINNHTLDGKKKQNCKCVRYSVNGECRVFLVATRDIAKGERLYYDYNGYEHEYPTQHFV 4o30 A 2.10 BS02 SAH A 1 R249 E250 F252 D285 S286 R312 F313 S315 G316 Y361 Y368 F373 V374 R92 E93 F95 D128 S129 R155 F156 S158 G159 Y204 Y211 F216 V217 2.1.1.43 B9RU15 RRRLLPFVSSEDPAQRLKQMGTLASALTELQMEFSDDLTYSSGMAPRSANQARFEEGGMQVLTKEDIETLEQCRAMCKRGDCPPLLVVFDSREGFTVEADGQIKDMTFIAEYTGDVDYIRNREHDDCDSMMTLLLAKDPSKSLVICPDKRGNIARFISGINNHTLDGKKKQNCKCVRYSVNGECRVFLVATRDIAKGERLYYDYNGYEHEYPTQHFV 4o30 B 2.10 BS01 III D 1 M216 Q217 M263 Y269 I276 D282 D285 S286 M287 M288 T289 K331 C332 V333 R334 Y335 T348 Y359 Y361 G363 Y364 E365 E367 Y368 M58 Q59 M105 Y111 I118 D124 D127 S128 M129 M130 T131 K173 C174 V175 R176 Y177 T190 Y201 Y203 G205 Y206 E207 E209 Y210 2.1.1.43 B9RU15 RRLLPFVSSEDPAQRLKQMGTLASALTELQMEFSDDLTYSSGMAPRSANQARFEEGGMQVLTKEDIETLEQCRAMCKRGDCPPLLVVFDSREGFTVEADGQIKDMTFIAEYTGDVDYIRNREHDDCDSMMTLLLAKDPSKSLVICPDKRGNIARFISGINNHTLDGKKKQNCKCVRYSVNGECRVFLVATRDIAKGERLYYDYNGYEHEYPTQHFV 4o30 B 2.10 BS02 SAH B 1 L187 E250 F252 D285 R312 F313 S315 G316 Y361 Y368 F373 V374 L29 E92 F94 D127 R154 F155 S157 G158 Y203 Y210 F215 V216 2.1.1.43 B9RU15 RRLLPFVSSEDPAQRLKQMGTLASALTELQMEFSDDLTYSSGMAPRSANQARFEEGGMQVLTKEDIETLEQCRAMCKRGDCPPLLVVFDSREGFTVEADGQIKDMTFIAEYTGDVDYIRNREHDDCDSMMTLLLAKDPSKSLVICPDKRGNIARFISGINNHTLDGKKKQNCKCVRYSVNGECRVFLVATRDIAKGERLYYDYNGYEHEYPTQHFV 4o4j A 2.20 BS01 GTP A 1 G10 Q11 A12 Q15 D98 A99 A100 N101 S140 G142 G143 G144 T145 G146 V177 E183 N206 Y224 N228 I231 G10 Q11 A12 Q15 D98 A99 A100 N101 S140 G142 G143 G144 T145 G146 V177 E183 N206 Y224 N228 I231 P81947 24470331 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDS 4o4j B 2.20 BS01 GDP B 1 G10 Q11 C12 Q15 S140 G143 G144 T145 G146 P173 V177 D179 E183 N206 Y224 N228 G10 Q11 C12 Q15 S138 G141 G142 T143 G144 P171 V175 D177 E181 N204 Y222 N226 Q6B856 24470331 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDA 4o4j B 2.20 BS02 POU B 1 Q293 F296 D297 S298 P307 R308 Y312 V335 N339 Y342 Q291 F294 D295 S296 P305 R306 Y310 V333 N337 Y340 Q6B856 24470331 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDA 4o4j C 2.20 BS01 GTP C 1 G10 Q11 A12 Q15 D98 A99 A100 N101 S140 G143 G144 T145 G146 I171 V177 E183 N206 Y224 N228 I231 G10 Q11 A12 Q15 D98 A99 A100 N101 S140 G143 G144 T145 G146 I171 V177 E183 N206 Y224 N228 I231 P81947 24470331 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV 4o4j D 2.20 BS01 GDP D 1 G10 Q11 C12 Q15 S140 G143 G144 T145 G146 E183 N206 Y224 N228 G10 Q11 C12 Q15 S138 G141 G142 T143 G144 E181 N204 Y222 N226 Q6B856 24470331 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 4o4j D 2.20 BS02 POU D 1 Q293 F296 D297 S298 P307 R308 Y312 N339 Y342 Q291 F294 D295 S296 P305 R306 Y310 N337 Y340 Q6B856 24470331 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 4o4j F 2.20 BS01 ACP F 1 K74 Q183 K184 Y185 L186 K198 D200 L240 N242 D318 M320 I330 E331 N333 K74 Q103 K104 Y105 L106 K118 D120 L153 N155 D215 M217 I227 E228 N230 E1BQ43 24470331 MYTFVVRDENSSVYAEVSRLLLATGQWKRLRKDNPRFNLMLGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELSESCTWFPESQVHVIQKYLEKPLLLEPGHRKFDIRSWVLVDHLYNIYLYREGVLRTSSEPYNSCHLTNHCIGRYEEGNEMFFEEFNQYLMDALELQIKHIIRSCLMCIEPAISTKHLHYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDVAISSVFPLASIFIKL 4o4l B 2.20 BS02 POU B 1 Q293 F296 D297 S298 R308 Y312 N339 Y342 Q291 F294 D295 S296 R306 Y310 N337 Y340 Q6B856 24470331 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDA 4o4l B 2.20 BS03 EP B 1 L217 L219 D226 H229 F272 P274 L275 T276 Q281 Q282 R284 L371 L215 L217 D224 H227 F270 P272 L273 T274 Q279 Q280 R282 L361 Q6B856 24470331 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDA 4o4l D 2.20 BS03 EP D 1 L217 D226 H229 L230 F272 P274 L275 T276 R278 R284 L371 L215 D224 H227 L228 F270 P272 L273 T274 R276 R282 L361 Q6B856 24470331 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAD 4o4y L 1.85 BS01 III A 1 Y29 Y93 D94 C95 N96 H101 Y29 Y93 D94 C95 N96 H101 EVLTQTPSSVSAAVGGTVTINCQASQSVYNKNYLAWYQQKPGQPPKRLIYSASTLASGVSSRFKGSGSGTQFTLTISDVQCDDVATYYCLGSYDCNRAECHAFGGGTKVVVEVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGC 4o4y H 1.85 BS01 III A 1 P32 N34 G49 G51 S53 N55 W57 G96 L97 Y98 N99 Y101 P32 N34 G49 G51 S53 N55 W57 G96 L97 Y98 N99 Y101 ESVEESGGRLVTPGTPLTLTCTVSGFSLSSYPMNWVRQAPGKGLEWIGGIGTSGNIWYASWAKGRFIISRASSTTVDLKVTSPTTEDTATYFCARGLYNDYTVWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 4o51 L 2.20 BS01 III M 1 Y33 Q95 A96 H98 Y33 Q95 A96 H98 EVLTQTPSSVSAAVGGTVTINCQASQSVYNKNYLAWYQQKPGQPPKRLIYSASTLASGVSSRFKGSGSGTQFTLTISDVQADDVATYYCLGSYDQAAHAFGGGTKVVVERTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE 4o51 H 2.20 BS01 III M 1 P32 N34 W46 G49 I50 G51 S53 N55 W57 G96 L97 Y98 N99 Y101 P32 N34 W46 G49 I50 G51 S53 N55 W57 G96 L97 Y98 N99 Y101 ESVEESGGRLVTPGTPLTLTCTVSGFSLSSYPMNWVRQAPGKGLEWIGGIGTSGNIWYASWAKGRFIISRASSTTVDLKVTSPTTEDTATYFCARGLYNDYTVWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 4o62 A 1.78 BS01 ZN A 1 C33 C38 C60 C71 C12 C17 C39 C50 Q504Y3 ENMYVNKVWVQCENENCLKWRLLSSEDSAKVDHDEPWYCFMNTDSRYNNCSISEED 4o62 B 1.78 BS01 III D 1 K28 V29 W30 V31 Q32 W41 L43 V52 D53 H54 E56 F78 K7 V8 W9 V10 Q11 W20 L22 V31 D32 H33 E35 F57 Q504Y3 ENMYVNKVWVQCENENCLKWRLLSSEDSAKVDHDEPWYCFMNTDSRYNNCSISEEDF 4o6f A 2.82 BS01 III B 1 V179 G183 F184 T185 E187 L191 H193 V215 Y240 I241 D242 Y245 R253 Y258 R306 Y344 N380 V177 G181 F182 T183 E185 L189 H191 V213 Y238 I239 D240 Y243 R251 Y256 R304 Y342 N378 2.1.1.-,2.1.1.43 Q9NRG4 24594358 AEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIES 4o6f A 2.82 BS05 SAH A 1 G16 K17 R19 H137 N182 A203 N206 H207 Y240 Y258 F260 G14 K15 R17 H135 N180 A201 N204 H205 Y238 Y256 F258 2.1.1.-,2.1.1.43 Q9NRG4 24594358 AEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIES 4o6q A 0.95 BS01 FMT A 1 A75 L77 H83 A74 L76 H82 O69756 24625274 SISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHATLFSNPSHTLWGKLDSIALGDTLTGGASSGGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPA 4o6q A 0.95 BS02 HEM A 1 H32 P34 G35 V37 T43 F51 Y56 L77 H83 L85 R129 H134 V137 Y138 M141 H31 P33 G34 V36 T42 F50 Y55 L76 H82 L84 R128 H133 V136 Y137 M140 O69756 24625274 SISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHATLFSNPSHTLWGKLDSIALGDTLTGGASSGGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPA 4o6s A 1.32 BS01 HEM A 1 H32 P34 V37 T43 F46 Y56 Y75 A83 L85 R129 H134 V137 Y138 M141 H31 P33 V36 T42 F45 Y55 Y74 A82 L84 R125 H130 V133 Y134 M137 O69756 24625274 SISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHYTLFSNPSATLWGKLDSIALGDTLTGGAGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPA 4o6s A 1.32 BS02 ZN A 1 D72 H74 D71 H73 O69756 24625274 SISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHYTLFSNPSATLWGKLDSIALGDTLTGGAGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPA 4o6t A 1.25 BS01 HEM A 1 H32 R33 P34 G35 Q36 V37 T43 Y56 Y75 L77 F78 A83 L85 R129 H134 V137 Y138 M141 H31 R32 P33 G34 Q35 V36 T42 Y55 Y74 L76 F77 A82 L84 R128 H133 V136 Y137 M140 O69756 24625274 SISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHYTLFSNPSATLWGKLDSIALGDTLTGGASSGGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPA 4o6u A 0.89 BS01 HEM A 1 H32 P34 G35 V37 T43 F46 F51 Y56 Y75 L77 F78 A83 L85 R129 H134 V137 Y138 M141 H31 P33 G34 V36 T42 F45 F50 Y55 Y74 L76 F77 A82 L84 R128 H133 V136 Y137 M140 O69756 24625274 SISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHYTLFSNPSATLWGKLDSIALGDTLTGGASSGGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPA 4ojl A 2.00 BS01 BGC A 1 T611 N612 A614 K615 E639 K662 T600 N601 A603 K604 E628 K651 G3M189 STGILTNKQAVARHFGVKQSEVVYFSVGVDLGGYKVIYDKETQRAYSLPVGIASGTTAVSLSTAAVLVHSAGSVDLGSLAVSREEYVTLPGSFDSGSTLNVKNELLTYTDGKYRWDGILPKTVAPGSTPASTGGVGLGAWISVGDASLRTQLANGDGSLIGIHPQGTLNNVLTVRTPEQYNAVGDGIADDTSKLKEMLSDINNVPETLPDAAAVNSYMEQVAVKIDLTKLYRFTETLYIPPGVSIEIPTSNFFTRECKQGLFYDPVDKNTAAISLMVYRKQPDGSYKLNKDVDYYPTGLDIDNGDAITCARKIDINNLNLITAPGVKVGVKWIGGAGCTTKGLSIGENTGSDITTARLPRVGLLQSASWGSIHENLRILYKTQGAVFIDSNGGAAVNNAYISRLGNTNGELEQAVYKPAGFTEVGDVAVTQFAGSEVKFNSPIIEQASFDFVHAGRDTDSYGLFMVDKPHIESSGGKKKHSFYLINTSSNVTLSGVGLSGQDPDLDSMYFLKNCPETARNVVRGQMPISGVKLVRGTGNYPTLVLDCTNMGSQFQFGEVGDIFYIKDVVGVKADTLYIDPVNGNNYNWGTNGTKPIRELTNIAKICQLFRCKSVYLNAGESVITSNTELPMVVFEGPGSLKANSGSSFLIKAGGTLSLIGLSGISTDGGHMFRVSTVEKVNIHTNCSVNAGAAYVVLSEVQGNIEYRQLFYSVNCSKYIGATAGQTIAGIMVKTATRPTGIDAAPVDGNVSLTYKIIE 4ojl C 2.00 BS02 BGC C 2 D590 P606 N628 D581 P597 N619 G3M189 KGSTGILTNKQAVARHFGVKQSEVVYFSVGVDLGGYKVIYDKETQRAYSLPVGIASGTTAVSLSTAAVLVHSAGSVDLGSLAVSREEYVTLPGSFDSGSTLNVKNELLTYTDGKYRWDGILPKTVAPGSTPASTGGVGLGAWISVGDASLRTQLANGDGSLIGIHPQGTLNNVLTVRTPEQYNAVGDGIADDTSKLKEMLSDINNVPETLPDAAAVNSYMEQVAVKIDLTKLYRFTETLYIPPGVSIEIPTSNFFTRECKQGLFYDPVDKNTAAISLMVYRKQPDGSYKLNKDVDYYPTGLDIDNGDAITCARKIDINNLNLITAPGVKVGVKWIGGAGCTTKGLSIGENTGSDITTARLPRVGLLQSASWGSIHENLRILYKTQGAVFIDSNGGAAVNNAYISRLGNTNGELEQAVYKPAGFTEVGDVAVTQFAGSEVKFNSPIIEQASFDFVHAGRDTDSYGLFMVDKPHIESSGGKKKHSFYLINTSSNVTLSGVGLSGQDPDLDSMYFLKNCPETARNVVRGQMPISGVKLVRGTGNYPTLVLDCTNMGSQFQFGEVGDIFYIKDVVGVKADTLYIDPVNGNNYNWGTNGTKPIRELTNIAKICQLFRCKSVYLNAGESVITSNTELPMVVFEGPGSLKANSGSSFLIKAGGTLSLIGLSGISTDGGHMFRVSTVEKVNIHTNCSVNAGAAYVVLSEVQGNIEYRQLFYSVNCSKYIGATAGQTIAGIMVKTATRPTGIDAAPVDGNVSLTYKII 4ojo A 2.00 BS01 LBT A 1 K577 K615 Q618 L619 K566 K604 Q607 L608 G3M189 STGILTNKQAVARHFGVKQSEVVYFSVGVDLGGYKVIYDKETQRAYSLPVGIASGTTAVSLSTAAVLVHSAGSVDLGSLAVSREEYVTLPGSFDSGSTLNVKNELLTYTDGKYRWDGILPKTVAPGSTPASTGGVGLGAWISVGDASLRTQLANGDGSLIGIHPQGTLNNVLTVRTPEQYNAVGDGIADDTSKLKEMLSDINNVPETLPDAAAVNSYMEQVAVKIDLTKLYRFTETLYIPPGVSIEIPTSNFFTRECKQGLFYDPVDKNTAAISLMVYRKQPDGSYKLNKDVDYYPTGLDIDNGDAITCARKIDINNLNLITAPGVKVGVKWIGGAGCTTKGLSIGENTGSDITTARLPRVGLLQSASWGSIHENLRILYKTQGAVFIDSNGGAAVNNAYISRLGNTNGELEQAVYKPAGFTEVGDVAVTQFAGSEVKFNSPIIEQASFDFVHAGRDTDSYGLFMVDKPHIESSGGKKKHSFYLINTSSNVTLSGVGLSGQDPDLDSMYFLKNCPETARNVVRGQMPISGVKLVRGTGNYPTLVLDCTNMGSQFQFGEVGDIFYIKDVVGVKADTLYIDPVNGNNYNWGTNGTKPIRELTNIAKICQLFRCKSVYLNAGESVITSNTELPMVVFEGPGSLKANSGSSFLIKAGGTLSLIGLSGISTDGGHMFRVSTVEKVNIHTNCSVNAGAAYVVLSEVQGNIEYRQLFYSVNCSKYIGATAGQTIAGIMVKTATRPTGIDAAPVDGNVSLTYKIIE 4ojo A 2.00 BS02 LBT B 1 K583 D585 K623 K572 D574 K612 G3M189 STGILTNKQAVARHFGVKQSEVVYFSVGVDLGGYKVIYDKETQRAYSLPVGIASGTTAVSLSTAAVLVHSAGSVDLGSLAVSREEYVTLPGSFDSGSTLNVKNELLTYTDGKYRWDGILPKTVAPGSTPASTGGVGLGAWISVGDASLRTQLANGDGSLIGIHPQGTLNNVLTVRTPEQYNAVGDGIADDTSKLKEMLSDINNVPETLPDAAAVNSYMEQVAVKIDLTKLYRFTETLYIPPGVSIEIPTSNFFTRECKQGLFYDPVDKNTAAISLMVYRKQPDGSYKLNKDVDYYPTGLDIDNGDAITCARKIDINNLNLITAPGVKVGVKWIGGAGCTTKGLSIGENTGSDITTARLPRVGLLQSASWGSIHENLRILYKTQGAVFIDSNGGAAVNNAYISRLGNTNGELEQAVYKPAGFTEVGDVAVTQFAGSEVKFNSPIIEQASFDFVHAGRDTDSYGLFMVDKPHIESSGGKKKHSFYLINTSSNVTLSGVGLSGQDPDLDSMYFLKNCPETARNVVRGQMPISGVKLVRGTGNYPTLVLDCTNMGSQFQFGEVGDIFYIKDVVGVKADTLYIDPVNGNNYNWGTNGTKPIRELTNIAKICQLFRCKSVYLNAGESVITSNTELPMVVFEGPGSLKANSGSSFLIKAGGTLSLIGLSGISTDGGHMFRVSTVEKVNIHTNCSVNAGAAYVVLSEVQGNIEYRQLFYSVNCSKYIGATAGQTIAGIMVKTATRPTGIDAAPVDGNVSLTYKIIE 4ojo B 2.00 BS01 LBT B 1 P552 K577 D578 K615 Q618 L619 P539 K564 D565 K602 Q605 L606 G3M189 GILTNKQAVARHFGVKQSEVVYFSVGVDLGGYKVIYDKETQRAYSLPVGIASGTTAVSLSTAAVLVHSAGSVDLGSLAVSREEYVTLPGSFDSGSTLNVKNELLTYTDGKYRWDGILPKTVAPGSTPASTGGVGLGAWISVGDASLRTQLANGDGSLIGIHPQGTLNNVLTVRTPEQYNAVGDGIADDTSKLKEMLSDINNVPETLPDAAAVNSYMEQVAVKIDLTKLYRFTETLYIPPGVSIEIPTSNFFTRECKQGLFYDPVDKNTAAISLMVYRKQPDGSYKLNKDVDYYPTGLDIDNGDAITCARKIDINNLNLITAPGVKVGVKWIGGAGCTTKGLSIGENTGSDITTARLPRVGLLQSASWGSIHENLRILYKTQGAVFIDSNGGAAVNNAYISRLGNTNGELEQAVYKPAGFTEVGDVAVTQFAGSEVKFNSPIIEQASFDFVHAGRDTDSYGLFMVDKPHIESSGGKKKHSFYLINTSSNVTLSGVGLSGQDPDLDSMYFLKNCPETARNVVRGQMPISGVKLVRGTGNYPTLVLDCTNMGSQFQFGEVGDIFYIKDVVGVKADTLYIDPVNGNNYNWGTNGTKPIRELTNIAKICQLFRCKSVYLNAGESVITSNTELPMVVFEGPGSLKANSGSSFLIKAGGTLSLIGLSGISTDGGHMFRVSTVEKVNIHTNCSVNAGAAYVVLSEVQGNIEYRQLFYSVNCSKYIGATAGQTIAGIMVKTATRPTGIDAAPVDGNVSLTYKIIE 4ojo B 2.00 BS02 LBT C 1 K583 D585 K570 D572 G3M189 GILTNKQAVARHFGVKQSEVVYFSVGVDLGGYKVIYDKETQRAYSLPVGIASGTTAVSLSTAAVLVHSAGSVDLGSLAVSREEYVTLPGSFDSGSTLNVKNELLTYTDGKYRWDGILPKTVAPGSTPASTGGVGLGAWISVGDASLRTQLANGDGSLIGIHPQGTLNNVLTVRTPEQYNAVGDGIADDTSKLKEMLSDINNVPETLPDAAAVNSYMEQVAVKIDLTKLYRFTETLYIPPGVSIEIPTSNFFTRECKQGLFYDPVDKNTAAISLMVYRKQPDGSYKLNKDVDYYPTGLDIDNGDAITCARKIDINNLNLITAPGVKVGVKWIGGAGCTTKGLSIGENTGSDITTARLPRVGLLQSASWGSIHENLRILYKTQGAVFIDSNGGAAVNNAYISRLGNTNGELEQAVYKPAGFTEVGDVAVTQFAGSEVKFNSPIIEQASFDFVHAGRDTDSYGLFMVDKPHIESSGGKKKHSFYLINTSSNVTLSGVGLSGQDPDLDSMYFLKNCPETARNVVRGQMPISGVKLVRGTGNYPTLVLDCTNMGSQFQFGEVGDIFYIKDVVGVKADTLYIDPVNGNNYNWGTNGTKPIRELTNIAKICQLFRCKSVYLNAGESVITSNTELPMVVFEGPGSLKANSGSSFLIKAGGTLSLIGLSGISTDGGHMFRVSTVEKVNIHTNCSVNAGAAYVVLSEVQGNIEYRQLFYSVNCSKYIGATAGQTIAGIMVKTATRPTGIDAAPVDGNVSLTYKIIE 4ojo C 2.00 BS02 LBT C 1 P552 K577 Q618 L619 P543 K568 Q609 L610 G3M189 KGSTGILTNKQAVARHFGVKQSEVVYFSVGVDLGGYKVIYDKETQRAYSLPVGIASGTTAVSLSTAAVLVHSAGSVDLGSLAVSREEYVTLPGSFDSGSTLNVKNELLTYTDGKYRWDGILPKTVAPGSTPASTGGVGLGAWISVGDASLRTQLANGDGSLIGIHPQGTLNNVLTVRTPEQYNAVGDGIADDTSKLKEMLSDINNVPETLPDAAAVNSYMEQVAVKIDLTKLYRFTETLYIPPGVSIEIPTSNFFTRECKQGLFYDPVDKNTAAISLMVYRKQPDGSYKLNKDVDYYPTGLDIDNGDAITCARKIDINNLNLITAPGVKVGVKWIGGAGCTTKGLSIGENTGSDITTARLPRVGLLQSASWGSIHENLRILYKTQGAVFIDSNGGAAVNNAYISRLGNTNGELEQAVYKPAGFTEVGDVAVTQFAGSEVKFNSPIIEQASFDFVHAGRDTDSYGLFMVDKPHIESSGGKKKHSFYLINTSSNVTLSGVGLSGQDPDLDSMYFLKNCPETARNVVRGQMPISGVKLVRGTGNYPTLVLDCTNMGSQFQFGEVGDIFYIKDVVGVKADTLYIDPVNGNNYNWGTNGTKPIRELTNIAKICQLFRCKSVYLNAGESVITSNTELPMVVFEGPGSLKANSGSSFLIKAGGTLSLIGLSGISTDGGHMFRVSTVEKVNIHTNCSVNAGAAYVVLSEVQGNIEYRQLFYSVNCSKYIGATAGQTIAGIMVKTATRPTGIDAAPVDGNVSLTYKII 4ojp A 1.95 BS01 MAL A 1 Y306 V426 Y427 K428 P429 A430 F443 Y295 V415 Y416 K417 P418 A419 F432 G3M189 STGILTNKQAVARHFGVKQSEVVYFSVGVDLGGYKVIYDKETQRAYSLPVGIASGTTAVSLSTAAVLVHSAGSVDLGSLAVSREEYVTLPGSFDSGSTLNVKNELLTYTDGKYRWDGILPKTVAPGSTPASTGGVGLGAWISVGDASLRTQLANGDGSLIGIHPQGTLNNVLTVRTPEQYNAVGDGIADDTSKLKEMLSDINNVPETLPDAAAVNSYMEQVAVKIDLTKLYRFTETLYIPPGVSIEIPTSNFFTRECKQGLFYDPVDKNTAAISLMVYRKQPDGSYKLNKDVDYYPTGLDIDNGDAITCARKIDINNLNLITAPGVKVGVKWIGGAGCTTKGLSIGENTGSDITTARLPRVGLLQSASWGSIHENLRILYKTQGAVFIDSNGGAAVNNAYISRLGNTNGELEQAVYKPAGFTEVGDVAVTQFAGSEVKFNSPIIEQASFDFVHAGRDTDSYGLFMVDKPHIESSGGKKKHSFYLINTSSNVTLSGVGLSGQDPDLDSMYFLKNCPETARNVVRGQMPISGVKLVRGTGNYPTLVLDCTNMGSQFQFGEVGDIFYIKDVVGVKADTLYIDPVNGNNYNWGTNGTKPIRELTNIAKICQLFRCKSVYLNAGESVITSNTELPMVVFEGPGSLKANSGSSFLIKAGGTLSLIGLSGISTDGGHMFRVSTVEKVNIHTNCSVNAGAAYVVLSEVQGNIEYRQLFYSVNCSKYIGATAGQTIAGIMVKTATRPTGIDAAPVDGNVSLTYKIIE 4ojp B 1.95 BS01 MAL B 1 Y306 V426 Y427 K428 A430 A444 Y293 V413 Y414 K415 A417 A431 G3M189 GILTNKQAVARHFGVKQSEVVYFSVGVDLGGYKVIYDKETQRAYSLPVGIASGTTAVSLSTAAVLVHSAGSVDLGSLAVSREEYVTLPGSFDSGSTLNVKNELLTYTDGKYRWDGILPKTVAPGSTPASTGGVGLGAWISVGDASLRTQLANGDGSLIGIHPQGTLNNVLTVRTPEQYNAVGDGIADDTSKLKEMLSDINNVPETLPDAAAVNSYMEQVAVKIDLTKLYRFTETLYIPPGVSIEIPTSNFFTRECKQGLFYDPVDKNTAAISLMVYRKQPDGSYKLNKDVDYYPTGLDIDNGDAITCARKIDINNLNLITAPGVKVGVKWIGGAGCTTKGLSIGENTGSDITTARLPRVGLLQSASWGSIHENLRILYKTQGAVFIDSNGGAAVNNAYISRLGNTNGELEQAVYKPAGFTEVGDVAVTQFAGSEVKFNSPIIEQASFDFVHAGRDTDSYGLFMVDKPHIESSGGKKKHSFYLINTSSNVTLSGVGLSGQDPDLDSMYFLKNCPETARNVVRGQMPISGVKLVRGTGNYPTLVLDCTNMGSQFQFGEVGDIFYIKDVVGVKADTLYIDPVNGNNYNWGTNGTKPIRELTNIAKICQLFRCKSVYLNAGESVITSNTELPMVVFEGPGSLKANSGSSFLIKAGGTLSLIGLSGISTDGGHMFRVSTVEKVNIHTNCSVNAGAAYVVLSEVQGNIEYRQLFYSVNCSKYIGATAGQTIAGIMVKTATRPTGIDAAPVDGNVSLTYKIIE 4ojt A 1.50 BS01 2WP A 1 A9 M10 E13 I52 V78 F153 E173 M174 E175 R194 F208 A10 M11 E14 I53 V79 F154 E174 M175 E176 R195 F209 3.2.2.9 Q9ZMY2 23148563 MGQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVATQLVQHDVDLSAFDHPLGFIPESAIFIETSGSLNALAKKIANEQHIALKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEKAGMSFDEFLEKSAHTSAKFLKSMVDEL 4ov2 A 2.60 BS01 CA A 1 D73 N75 D77 R79 E81 E84 D58 N60 D62 R64 E66 E69 P62168 LTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTTPEKRVDRIFAMMDKNADGKLTLQEFQEGSK 4ov2 A 2.60 BS02 CA A 2 D109 D111 D113 Y115 E120 D94 D96 D98 Y100 E105 P62168 LTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTTPEKRVDRIFAMMDKNADGKLTLQEFQEGSK 4ov2 A 2.60 BS03 CA A 3 D157 N159 D161 K163 E168 D134 N136 D138 K140 E145 P62168 LTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTTPEKRVDRIFAMMDKNADGKLTLQEFQEGSK 4ov2 D 2.60 BS01 CA D 1 D73 N75 D77 R79 I80 E81 E84 D63 N65 D67 R69 I70 E71 E74 P62168 LKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGS 4ov2 D 2.60 BS03 CA D 3 D157 N159 D161 K163 L164 E168 D147 N149 D151 K153 L154 E158 P62168 LKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGS 4p04 B 1.95 BS01 SO4 B 1 S37 D38 Q59 S37 D38 Q59 2.8.2.22 E2QE64 24601529 AGFKPAPPAGQLGAVIVDPYGNAPLTALVDLDSHVISDVKVTVHGKGEKGVEISYPVGQESLKTYDGVPIFGLYQKFANKVTVEWKENGKVMKDDYVVHTSAIVNNYMDNRSISDLQQTKVIKVAPGFEDRLYLVNTHTFTAQGSDLHWHGEKDKNAGILDAGPATGALPFDIAPFTFIVDTEGEYRWWLDQDTFYDGRDRDINKRGYLMGIRETPRGTFTAVQGQHWYEFDMMGQVLEDHKLPRGFADATHESIETPNGTVLLRVGKSNYRRDDGVHVTTIRDHILEVDKSGRVVDVWDLTKILDPKRDALLGALDAGAHAGQQAKLEPDTPFGDALGVGPGRNWAHVNSIAYDAKDDSIILSSRHQGVVKIGRDKQVKWILAPSKGWEKPLASKLLKPVDANGKPITCNENGLCENSDFDFTYTQNTAWISSKGTLTIFDNGDGRHLEQPALPTMKYSRFVEYKIDEKKGTVQQVWEYGKERGYDFYSPITSIIEYQADRNTMFGFGGSIHLFDVGQPTVGKLNEIDYKTKEVKVEIDVLSDKPNQTHYRALLVRPQQMFK 4p05 A 2.05 BS01 4NS A 1 F171 Y208 H252 H356 N358 N436 I500 T501 T557 Y559 F171 Y208 H252 H349 N351 N429 I493 T494 T550 Y552 2.8.2.22 E2QE64 24601529 AGFKPAPPAGQLGAVIVDPYGNAPLTALVDLDSHVISDVKVTVHGKGEKGVEISYPVGQESLKTYDGVPIFGLYQKFANKVTVEWKENGKVMKDDYVVHTSAIVNNYMDNRSISDLQQTKVIKVAPGFEDRLYLVNTHTFTAQGSDLHWHGEKDKNAGILDAGPATGALPFDIAPFTFIVDTEGEYRWWLDQDTFYDGRDRDINKRGYLMGIRETPRGTFTAVQGQHWYEFDMMGQVLEDHKLPRGFADATHESIETPNGTVLLRVGKSNYRRDDGVHVTTIRDHILEVDKSGRVVDVWDLTKILDPKRDALLGALDAGAAHAGQQAKLEPDTPFGDALGVGPGRNWAHVNSIAYDAKDDSIILSSRHQGVVKIGRDKQVKWILAPSKGWEKPLASKLLKPVDANGKPITCNENGLCENSDFDFTYTQNTAWISSKGTLTIFDNGDGRHLEQPALPTMKYSRFVEYKIDEKKGTVQQVWEYGKERGYDFYSPITSIIEYQADRNTMFGFGGSIHLFDVGQPTVGKLNEIDYKTKEVKVEIDVLSDKPNQTHYRALLVRPQQMFK 4p06 A 2.10 BS02 MUX A 1 Y208 H252 H356 N358 N436 I500 T501 T557 Y208 H252 H349 N351 N429 I493 T494 T550 2.8.2.22 E2QE64 24601529 AGFKPAPPAGQLGAVIVDPYGNAPLTALVDLDSHVISDVKVTVHGKGEKGVEISYPVGQESLKTYDGVPIFGLYQKFANKVTVEWKENGKVMKDDYVVHTSAIVNNYMDNRSISDLQQTKVIKVAPGFEDRLYLVNTHTFTAQGSDLHWHGEKDKNAGILDAGPATGALPFDIAPFTFIVDTEGEYRWWLDQDTFYDGRDRDINKRGYLMGIRETPRGTFTAVQGQHWYEFDMMGQVLEDHKLPRGFADATHESIETPNGTVLLRVGKSNYRRDDGVHVTTIRDHILEVDKSGRVVDVWDLTKILDPKRDALLGALDAGAAHAGQQAKLEPDTPFGDALGVGPGRNWAHVNSIAYDAKDDSIILSSRHQGVVKIGRDKQVKWILAPSKGWEKPLASKLLKPVDANGKPITCNENGLCENSDFDFTYTQNTAWISSKGTLTIFDNGDGRHLEQPALPTMKYSRFVEYKIDEKKGTVQQVWEYGKERGYDFYSPITSIIEYQADRNTMFGFGGSIHLFDVGQPTVGKLNEIDYKTKEVKVEIDVLSDKPNQTHYRALLVRPQQMFK 4p06 A 2.10 BS03 SO4 B 1 H150 K153 G163 H150 K153 G163 2.8.2.22 E2QE64 24601529 AGFKPAPPAGQLGAVIVDPYGNAPLTALVDLDSHVISDVKVTVHGKGEKGVEISYPVGQESLKTYDGVPIFGLYQKFANKVTVEWKENGKVMKDDYVVHTSAIVNNYMDNRSISDLQQTKVIKVAPGFEDRLYLVNTHTFTAQGSDLHWHGEKDKNAGILDAGPATGALPFDIAPFTFIVDTEGEYRWWLDQDTFYDGRDRDINKRGYLMGIRETPRGTFTAVQGQHWYEFDMMGQVLEDHKLPRGFADATHESIETPNGTVLLRVGKSNYRRDDGVHVTTIRDHILEVDKSGRVVDVWDLTKILDPKRDALLGALDAGAAHAGQQAKLEPDTPFGDALGVGPGRNWAHVNSIAYDAKDDSIILSSRHQGVVKIGRDKQVKWILAPSKGWEKPLASKLLKPVDANGKPITCNENGLCENSDFDFTYTQNTAWISSKGTLTIFDNGDGRHLEQPALPTMKYSRFVEYKIDEKKGTVQQVWEYGKERGYDFYSPITSIIEYQADRNTMFGFGGSIHLFDVGQPTVGKLNEIDYKTKEVKVEIDVLSDKPNQTHYRALLVRPQQMFK 4p06 B 2.10 BS01 MUX B 1 Y208 H252 A320 H356 N358 N436 I500 T501 T557 Y559 Y208 H252 A320 H349 N351 N429 I493 T494 T550 Y552 2.8.2.22 E2QE64 24601529 AGFKPAPPAGQLGAVIVDPYGNAPLTALVDLDSHVISDVKVTVHGKGEKGVEISYPVGQESLKTYDGVPIFGLYQKFANKVTVEWKENGKVMKDDYVVHTSAIVNNYMDNRSISDLQQTKVIKVAPGFEDRLYLVNTHTFTAQGSDLHWHGEKDKNAGILDAGPATGALPFDIAPFTFIVDTEGEYRWWLDQDTFYDGRDRDINKRGYLMGIRETPRGTFTAVQGQHWYEFDMMGQVLEDHKLPRGFADATHESIETPNGTVLLRVGKSNYRRDDGVHVTTIRDHILEVDKSGRVVDVWDLTKILDPKRDALLGALDAGAAHAGQQAKLEPDTPFGDALGVGPGRNWAHVNSIAYDAKDDSIILSSRHQGVVKIGRDKQVKWILAPSKGWEKPLASKLLKPVDANGKPITCNENGLCENSDFDFTYTQNTAWISSKGTLTIFDNGDGRHLEQPALPTMKYSRFVEYKIDEKKGTVQQVWEYGKERGYDFYSPITSIIEYQADRNTMFGFGGSIHLFDVGQPTVGKLNEIDYKTKEVKVEIDVLSDKPNQTHYRALLVRPQQMFK 4p07 A 2.59 BS01 SO4 A 1 H252 V323 H356 N358 R374 H436 I500 T501 Y559 H252 V322 H355 N357 R373 H435 I499 T500 Y558 2.8.2.22 E2QE64 24601529 AGFKPAPPAGQLGAVIVDPYGNAPLTALVDLDSHVISDVKVTVHGKGEKGVEISYPVGQESLKTYDGVPIFGLYQKFANKVTVEWKENGKVMKDDYVVHTSAIVNNYMDNRSISDLQQTKVIKVAPGFEDRLYLVNTHTFTAQGSDLHWHGEKDKNAGILDAGPATGALPFDIAPFTFIVDTEGEYRWWLDQDTFYDGRDRDINKRGYLMGIRETPRGTFTAVQGQHWYEFDMMGQVLEDHKLPRGFADATHESIETPNGTVLLRVGKSNYRRDDGVHVTTIRDHILEVDKSGRVVDVWDLTKILDPKRDALLGALDAGAVVNVDLAHAGQQAKLEPDTPFGDALGVGPGRNWAHVNSIAYDAKDDSIILSSRHQGVVKIGRDKQVKWILAPSKGWEKPLASKLLKPVDANGKPITCNENGLCENSDFDFTYTQHTAWISSKGTLTIFDNGDGRHLEQPALPTMKYSRFVEYKIDEKKGTVQQVWEYGKERGYDFYSPITSIIEYQADRNTMFGFGGSIHLFDVGQPTVGKLNEIDYKTKEVKVEIDVLSDKPNQTHYRALLVRPQQMFK 4p07 B 2.59 BS01 SO4 B 1 H252 V323 H356 N358 R374 H436 I500 T501 H252 V322 H355 N357 R373 H435 I499 T500 2.8.2.22 E2QE64 24601529 AGFKPAPPAGQLGAVIVDPYGNAPLTALVDLDSHVISDVKVTVHGKGEKGVEISYPVGQESLKTYDGVPIFGLYQKFANKVTVEWKENGKVMKDDYVVHTSAIVNNYMDNRSISDLQQTKVIKVAPGFEDRLYLVNTHTFTAQGSDLHWHGEKDKNAGILDAGPATGALPFDIAPFTFIVDTEGEYRWWLDQDTFYDGRDRDINKRGYLMGIRETPRGTFTAVQGQHWYEFDMMGQVLEDHKLPRGFADATHESIETPNGTVLLRVGKSNYRRDDGVHVTTIRDHILEVDKSGRVVDVWDLTKILDPKRDALLGALDAGAVVNVDLAHAGQQAKLEPDTPFGDALGVGPGRNWAHVNSIAYDAKDDSIILSSRHQGVVKIGRDKQVKWILAPSKGWEKPLASKLLKPVDANGKPITCNENGLCENSDFDFTYTQHTAWISSKGTLTIFDNGDGRHLEQPALPTMKYSRFVEYKIDEKKGTVQQVWEYGKERGYDFYSPITSIIEYQADRNTMFGFGGSIHLFDVGQPTVGKLNEIDYKTKEVKVEIDVLSDKPNQTHYRALLVRPQQMFK 4p31 A 2.05 BS01 ADP A 1 Y13 R16 V18 G39 A40 G41 K42 T43 T44 Y12 R15 V17 G38 A39 G40 K41 T42 T43 3.6.3.- P0A9V1 24639492 ATLTAKNLAKAYKGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDDDDISLLPLHARARRGIGYLPQEASIFRRLSVYDNLMAVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQSLSGGERRRVEIARALAANPKFILLDEPFAGVDPISVIDIKRIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQDEHVKRVYL 4p31 A 2.05 BS02 MG A 1 T43 Q85 T42 Q84 3.6.3.- P0A9V1 24639492 ATLTAKNLAKAYKGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDDDDISLLPLHARARRGIGYLPQEASIFRRLSVYDNLMAVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQSLSGGERRRVEIARALAANPKFILLDEPFAGVDPISVIDIKRIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQDEHVKRVYL 4p31 B 2.05 BS01 ADP B 1 Y13 R16 V18 N38 G39 A40 G41 K42 T43 T44 Y12 R15 V17 N37 G38 A39 G40 K41 T42 T43 3.6.3.- P0A9V1 24639492 ATLTAKNLAKAYKGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDDDDISLLPLHARARRGIGYLPQEASIFRRLSVYDNLMAVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQSLSGGERRRVEIARALAANPKFILLDEPFAGVDPISVIDIKRIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQDEHVK 4p32 A 1.55 BS02 MG A 1 T43 Q85 E163 T42 Q84 E162 3.6.3.- P0A9V1 24639492 ATLTAKNLAKAYKGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDDDDISLLPLHARARRGIGYLPQEASIFRRLSVYDNLMAVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQSLSGGERRRVEIARALAANPKFILLDEPFAGVDPISVIDIKRIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQDEHVKRVYL 4p33 A 1.65 BS01 NA A 1 T43 Q85 D162 Q163 T42 Q84 D161 Q162 3.6.3.- P0A9V1 24639492 ATLTAKNLAKAYKGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDDDDISLLPLHARARRGIGYLPQEASIFRRLSVYDNLMAVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQSLSGGERRRVEIARALAANPKFILLDQPFAGVDPISVIDIKRIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQDEHVKRVYLG