2mdg A BS01 ZN A 1 C6 C9 H22 H26 C6 C9 H22 H26 Q2M1K9 MGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPICGERFPSLLTLTEHKVTH 3j4k A 8.00 BS01 ADP A 1 G13 S14 G15 L16 K18 D157 G182 R210 K213 E214 G302 T303 M305 Y306 K336 G13 S14 G15 L16 K18 D157 G182 R210 K213 E214 G302 T303 M305 Y306 K336 P68135 24021812 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 3j4k B 8.00 BS01 ADP B 1 S155 G156 D157 G158 V159 A181 G182 R210 K213 E214 G302 T303 M305 Y306 K336 S155 G156 D157 G158 V159 A181 G182 R210 K213 E214 G302 T303 M305 Y306 K336 P68135 24021812 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 3j4k D 8.00 BS01 ADP D 1 D11 G13 S14 G15 L16 K18 Q137 G156 D157 R210 E214 G302 T303 M305 Y306 D11 G13 S14 G15 L16 K18 Q137 G156 D157 R210 E214 G302 T303 M305 Y306 P68135 24021812 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 3vy2 A 1.60 BS01 FMN A 1 H27 V29 N30 T31 W32 Y35 P47 V48 G49 G50 M51 H52 K53 T54 W106 H27 V29 N30 T31 W32 Y35 P47 V48 G49 G50 M51 H52 K53 T54 W106 Q46604 MLPGTFFEVLKNEGVVAIATQGEDGPHLVNTWDSYLKVLDGNRIVVPVGGMHKTEANVARDERVLMTLGSRKVAGRNGPGTGFLIRGSAAFRTDGPEFEAIARFKWARAALVITVVSAEQTL 3vy6 A 2.00 BS01 BGC A 1 G34 G35 Y104 G147 S148 L149 D151 G13 G14 Y83 G126 S127 L128 D130 O60844 RSSSYSGEYGSGGGKRFSHSGNQLDGPITALRVRVNTYYIVGLQVRYGKVWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLVFVTDKGRYLSFGKDSGTSFNAVPLHPNTVLRFISGRSGSLIDAIGLHWDV 3vya A 2.40 BS01 FMN A 1 V15 H27 V29 N30 T31 Y32 Y35 P47 G49 G50 M51 H52 K53 T54 V13 H25 V27 N28 T29 Y30 Y33 P45 G47 G48 M49 H50 K51 T52 Q46604 PGTFFEVLKNEGVVAIATQGEDGPHLVNTYNSYLKVLDGNRIVVPVGGMHKTEANVARDERVLMTLGSRKVAGRNGPGTGFLIRGSAAFRTDGPEFEAIARFKWARAALVITVVSAEQTL 3w8n A 2.20 BS01 C5P A 1 S33 G34 Y37 R38 S98 A101 R107 S31 G32 Y35 R36 S96 A99 R105 2.7.4.25 Q5SL35 GIVTIDGPSASGKSSVARRVAAALGVPYLSSGLLYRAAAFLALRAGVDPGDEEGLLALLEGLGVRLLAQAEGNRVLADGEDLTSFLHTPEVDRVVSAVARLPGVRAWVNRRLKEVPPPFVAEGRDMGTAVFPEAAHKFYLTASPEVRAWRRAPQAYEEVLRDLLRRDERDKAQSAPAPDALVLDTGGMTLDEVVAWVLAHI 3zc6 A 2.42 BS01 VFC A 1 L828 G829 K830 G831 G834 S835 V836 A853 K855 V884 M902 E903 Y904 L905 G908 C909 R911 N954 L956 D967 L15 G16 K17 G18 G21 S22 V23 A40 K42 V71 M85 E86 Y87 L88 G91 C92 R94 N137 L139 D150 2.7.10.2,2.7.1.112 P52333 23540648 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWS 3zc6 B 2.42 BS01 VFC B 1 L828 G829 K830 G831 G834 S835 V836 A853 K855 V884 M902 E903 Y904 L905 G908 C909 L956 D967 L16 G17 K18 G19 G22 S23 V24 A41 K43 V72 M86 E87 Y88 L89 G92 C93 L140 D151 2.7.10.2,2.7.1.112 P52333 23540648 DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWS 3zc6 D 2.42 BS01 VFC D 1 L828 G829 K830 G831 G834 S835 V836 A853 K855 M902 E903 Y904 L905 G908 L956 D967 L15 G16 K17 G18 G21 S22 V23 A40 K42 M84 E85 Y86 L87 G90 L138 D149 2.7.10.2,2.7.1.112 P52333 23540648 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMLSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWS 3zf8 A 1.98 BS01 GDP A 1 P122 M123 Q124 I149 P151 Q187 R209 M213 N236 A237 D238 Y279 H389 P28 M29 Q30 I55 P57 Q93 R103 M107 N130 A131 D132 Y173 H283 P39107 24026536 HIAHYDLNKLHSTSEAAVNKEHILILTPMQTFHQQYWDNLLQLNYPRELIELGFITPRTATGDLALKKLENAIKKVQTDKKTQRFSKITILRQNSALDVQKERRAAMALARNELLFSTIGPHTSWVLWLNADIIETPPSLIQDMTKHNKAILAANIYQRFYDEEKKQPSIRPYDFNNWQESDTGLEIASQMGDDEIIVEGYAEIATYRPLMAHFYDANGVPGEEMALDGVGGGCTLVKAEVHRDGAMFPNFPFYHLIETEGFAKMAKRLNYDVFGLPNYLVYHIEEEN 3zf8 A 1.98 BS02 MN A 1 D238 Y279 H389 D132 Y173 H283 P39107 24026536 HIAHYDLNKLHSTSEAAVNKEHILILTPMQTFHQQYWDNLLQLNYPRELIELGFITPRTATGDLALKKLENAIKKVQTDKKTQRFSKITILRQNSALDVQKERRAAMALARNELLFSTIGPHTSWVLWLNADIIETPPSLIQDMTKHNKAILAANIYQRFYDEEKKQPSIRPYDFNNWQESDTGLEIASQMGDDEIIVEGYAEIATYRPLMAHFYDANGVPGEEMALDGVGGGCTLVKAEVHRDGAMFPNFPFYHLIETEGFAKMAKRLNYDVFGLPNYLVYHIEEEN 3zg2 A 2.80 BS01 HEM A 1 Y103 Y116 L127 L134 A288 A291 G292 T295 T299 L356 V359 R361 G414 F415 H420 C422 I423 G424 A428 Y76 Y89 L100 L107 A259 A262 G263 T266 T270 L327 V330 R332 G385 F386 H391 C393 I394 G395 A399 1.14.13.70 Q7Z1V1 AKKTPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKK 3zg2 A 2.80 BS02 UDO A 1 Y103 M106 Y116 L127 A287 F290 A291 T295 L356 M360 M460 Y76 M79 Y89 L100 A258 F261 A262 T266 L327 M331 M431 1.14.13.70 Q7Z1V1 AKKTPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKK 3zg3 A 2.90 BS01 HEM A 1 Y103 A288 A291 G292 T295 T299 V359 R361 G414 F415 H420 C422 I423 G424 A428 Y75 A255 A258 G259 T262 T266 V326 R328 G381 F382 H387 C389 I390 G391 A395 1.14.13.70 Q7Z1V1 KKTPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKK 3zg3 A 2.90 BS02 UDD A 1 Y103 I105 Y116 L127 V213 A287 A291 T295 M358 M360 Y75 I77 Y88 L99 V185 A254 A258 T262 M325 M327 1.14.13.70 Q7Z1V1 KKTPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKK 3zh2 A 2.10 BS01 NUC E 1 F34 D35 I36 Y67 A80 G81 F82 K84 A85 P86 G87 K88 S89 D90 K91 I105 V229 H232 A233 S234 F32 D33 I34 Y65 A78 G79 F80 K82 A83 P84 G85 K86 S87 D88 K89 I103 V227 H230 A231 S232 1.1.1.27 Q76NM3 24043813 PKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA 3zh2 B 2.10 BS01 NUC E 1 G13 M14 I36 V37 M40 K44 A80 F82 I105 G11 M12 I34 V35 M38 K42 A78 F80 I97 1.1.1.27 Q76NM3 24043813 PKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA 3zh2 C 2.10 BS01 NUC G 1 D35 I36 Y67 A80 F82 K84 A85 P86 G87 K88 S89 D90 K91 I105 V229 H232 A233 S234 D34 I35 Y66 A79 F81 K83 A84 P85 G86 K87 S88 D89 K90 I104 V228 H231 A232 S233 1.1.1.27 Q76NM3 24043813 APKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA 3zh2 D 2.10 BS01 NUC G 1 G13 M14 I36 V37 M40 K44 A80 G81 F82 K84 I105 G11 M12 I34 V35 M38 K42 A78 G79 F80 K82 I100 1.1.1.27 Q76NM3 24043813 PKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA 3znm E 2.40 BS01 SIA E 1 Y91 L129 G130 V131 S132 S133 H179 N182 E186 L190 Q222 Y91 L129 G130 V131 S132 S133 H179 N182 E186 L190 Q222 Q6DQ34 24036174 DQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSSHEASLGVSSACPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSP 4ba9 F 2.73 BS01 MG F 1 D1230 D1234 D92 D96 2.7.7.- Q9UBZ9 GPHMHKKSFFDKKRSERASNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYCTDLIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQ 4boc A 2.65 BS01 NUC N 1 H624 Q629 W1026 H1030 R1059 R1113 K1116 H404 Q409 W806 H810 R839 R872 K875 2.7.7.6 O00411 QLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEELGAPEALREQPWPLPVQMELGKLLAEMLVQATQMPCSLDRSSRLVPVLYHVYSFRNVQQIGILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQPYRLDSRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS 4boc A 2.65 BS02 NUC R 1 T498 S611 R613 N614 I618 K767 E771 S774 L775 L816 G817 S818 R822 Q992 M995 T996 K1012 V1149 D1151 T281 S391 R393 N394 I398 K547 E551 S554 L555 L596 G597 S598 R602 Q772 M775 T776 K792 V908 D910 2.7.7.6 O00411 QLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEELGAPEALREQPWPLPVQMELGKLLAEMLVQATQMPCSLDRSSRLVPVLYHVYSFRNVQQIGILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQPYRLDSRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS 4boc A 2.65 BS03 NUC T 1 Q493 G494 S611 I620 R672 H745 R759 Q766 R770 H773 S774 A777 E778 Y781 R803 Y807 P811 H812 Q992 T996 G1000 V1001 T1002 Y1004 G1005 Q1009 R1113 K1114 Q276 G277 S391 I400 R452 H525 R539 Q546 R550 H553 S554 A557 E558 Y561 R583 Y587 P591 H592 Q772 T776 G780 V781 T782 Y784 G785 Q789 R872 K873 2.7.7.6 O00411 QLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEELGAPEALREQPWPLPVQMELGKLLAEMLVQATQMPCSLDRSSRLVPVLYHVYSFRNVQQIGILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQPYRLDSRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS 4bpu A 2.70 BS01 ZN A 1 C121 C122 C128 C131 C118 C119 C125 C128 2.7.7.- P49642 24043831 FDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKG 4bpw A 3.00 BS02 MG A 1 D109 D111 D306 V309 D106 D108 D296 V299 2.7.7.- P49642 24043831 FDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKGEL 4bpw A 3.00 BS03 MG A 2 D109 D111 D106 D108 2.7.7.- P49642 24043831 FDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKGEL 4bpw A 3.00 BS04 UTP A 1 D79 D109 D111 S160 R163 H166 H315 L316 L317 K318 D76 D106 D108 S157 R160 H163 H305 L306 L307 K308 2.7.7.- P49642 24043831 FDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKGEL 4bpw C 3.00 BS03 MG C 2 D109 D111 S160 D106 D108 S157 2.7.7.- P49642 24043831 FDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELTSLAPYVKVFEHFLENLDKSRKG 4bpw C 3.00 BS04 UTP C 1 D109 D111 S160 R162 R163 H166 H315 L316 L317 K318 H324 D106 D108 S157 R159 R160 H163 H302 L303 L304 K305 H311 2.7.7.- P49642 24043831 FDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELTSLAPYVKVFEHFLENLDKSRKG 4btj A 2.16 BS01 ADP A 1 I64 G65 G66 G68 I72 A85 K87 C115 M131 Q132 L133 Q134 N137 S182 N183 L199 D200 I20 G21 G22 G24 I28 A41 K43 C71 M87 Q88 L89 Q90 N93 S138 N139 L155 D156 2.7.11.1,2.7.11.26 Q5TCY1 24039150 ADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEK 4btj B 2.16 BS01 ATP B 1 I64 G65 G66 I72 A85 K87 C115 M131 Q132 L133 Q134 N137 S182 N183 L199 D200 I20 G21 G22 I28 A41 K43 C71 M87 Q88 L89 Q90 N93 S138 N139 L155 D156 2.7.11.1,2.7.11.26 Q5TCY1 24039150 ADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKA 4btk A 2.00 BS01 DTQ A 1 I64 I72 A85 K87 E101 C115 M131 Q132 L133 Q134 G135 L199 D200 I19 I24 A37 K39 E53 C67 M83 Q84 L85 Q86 G87 L151 D152 2.7.11.1,2.7.11.26 Q5TCY1 24039150 DILPANYVVKDRWKVLKKIGGGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWE 4btm A 2.54 BS01 F8E A 1 I64 I72 A85 K87 C115 M131 Q132 L133 Q134 S182 L199 I20 I28 A41 K43 C71 M87 Q88 L89 Q90 S138 L155 2.7.11.1,2.7.11.26 Q5TCY1 24039150 ADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEK 4btm B 2.54 BS01 F8E B 1 I64 G66 F69 I72 A85 C115 M131 Q132 L133 Q134 N183 L199 D200 I20 G22 F25 I28 A41 C71 M87 Q88 L89 Q90 N139 L155 D156 2.7.11.1,2.7.11.26 Q5TCY1 24039150 ADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKA 4bx7 B 2.26 BS01 B4F B 1 N23 L25 S27 Y43 S45 V47 N49 W79 S88 T90 W92 W108 L110 S112 K121 L124 D128 N8 L10 S12 Y28 S30 V32 N34 W64 S73 T75 W77 W93 L95 S97 K106 L109 D113 P22629 GITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4bxr A 2.20 BS01 III C 1 F959 T963 F978 N980 Y994 Y996 A999 H1003 L1013 F1015 Q1019 E1021 F19 T23 F38 N40 Y54 Y56 A59 H63 L73 F75 Q79 E81 E7FCY1 QSDSKIEKMLPDGGRLVVFPNGTRKELSADGQTVKVMFFNGDVKHTMPDQRVIYYYAEAQTTHITYPDGMEVLQFPNNQTEKHFPDGRKEITFPDQTVKTLHPDGREESVLTDGTIIQLNPDGSKVIQFNTGQREIHTADFKRREYPDGTVKTVYSDGRQETQYPTGRVRLKDPQGKVIMDTK 4bxr B 2.20 BS01 III D 1 F959 V976 F978 F979 N980 Y994 Y996 A999 H1003 L1013 F1015 Q1019 E1021 F1033 L1041 F16 V33 F35 F36 N37 Y51 Y53 A56 H60 L70 F72 Q76 E78 F90 L98 E7FCY1 SKIEKMLPDGGRLVVFPNGTRKELSADGQTVKVMFFNGDVKHTMPDQRVIYYYAEAQTTHITYPDGMEVLQFPNNQTEKHFPDGRKEITFPDQTVKTLHPDGREESVLTDGTIIQLNPDGSKVIQFNTGQREIHTADFKRREYPDGTVKTVYSDGRQETQYPTGRVRLKDPQGKVIMDTKA 4c0a C 3.30 BS01 G3D C 1 A27 A28 G29 K30 T31 T32 N126 K127 D129 C159 A160 T161 A10 A11 G12 K13 T14 T15 N109 K110 D112 C142 A143 T144 P84080 MRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLR 4gdx B 1.67 BS01 GLU B 1 T399 N401 E420 D423 S451 S452 T19 N21 E40 D43 S71 S72 2.3.2.2,3.4.19.13,3.4.19.14 P19440 TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY 4gqk A 2.36 BS01 ADP A 1 F4 F8 S12 G14 I15 E16 V80 S81 P83 T164 L337 F5 F9 S13 G15 I16 E17 V81 S82 P84 T165 L338 Q9KS45 ATPDFPTHFPKSSIGIENELAGLVVAMPANSAQKFGYVKSAQGDALFMLTKDMNQGSYQRPPSLQDGKNYQNWQTHTVELVSYPCEMDDKAAVETRKQAMLWLATHFTTHIDQSNHQPLAPIQSEDGRFVIEITNAKHVIAAGNGISAESQGQTITMTPSGQQATVGVAAKGFGTSATPELRLLESAPWYQKSLKSQFASLTSAENLDDKELAANVFAYLTSIYLKTAELAKKFGIYINEWDPMSEQITPNANGLTDPKVKNAWEILPRTKPSKIVEILSKSDAKAVMKHIKPQLQSRYSESLSKNVFQYFQDGGEVAGHGINNATVGDKHSPELAILFEFRTVPNELQSYLPKTE 4gub A 2.20 BS01 0Y4 A 1 L45 V53 E55 V66 K68 I95 F113 E114 H115 V116 N118 M163 I174 D175 L44 V52 E54 V65 K67 I94 F112 E113 H114 V115 N117 M162 I173 D174 2.7.11.1 P68400 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 4h7v A 1.80 BS02 GLC A 1 D61 Y64 H104 F145 F164 Q168 R198 E254 H326 D327 R414 D59 Y62 H102 F143 F162 Q166 R196 E252 H324 D325 R412 5.4.11.99 Q2PS28 GAPWWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYDISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDNPYRDYYFWRDGKDGHEPNNYPSFFGGSAWEKDPVTGQYYLHYFGRQQPDLNWDTPKLREELYAMLRFWLDKGVSGMRFATVATYSKTPGFPDLTPEQMKNFAEAYTQGPNLHRYLQEMHEKVFDHYDAVTAGEIFGAPLNQVPLFIDSRRKELDMAFTFDLIRYDRALDRWHTIPRTLADFRQTIDKVDAIAGEYGWNTFFLGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTPFIFQGDELGMTNYPFKTLQDFDDIEVKGFFQDYVETGKATAEELLTNVALTSRNNARTPFQWDDSANAGFTTGKPWLKVNPNYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSYRDIDPSNADVYAYTRSQDGETYLVVVNFKAEPRSFTLPDGMHIAETLIESSSPAAPAAGAASLELQPWQSGIYKVK 4h8i A 2.00 BS01 11W A 1 D58 G59 Y61 P89 L90 A91 R96 V138 G141 A142 T143 K172 E191 D56 G57 Y59 P87 L88 A89 R94 V136 G139 A140 T141 K170 E189 P42260 NRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP 4h8k A 2.30 BS01 NUC C 1 G11 A12 R13 G14 N15 N45 N77 E79 R121 G9 A10 R11 G12 N13 N43 N75 E77 R119 3.1.26.4 E0X767 23500886 KIIIYTDGGARGNPGPAGIGVVITDEKGNTLHESSAYIGETTNNVAEYEALIRALEDLQMFGDKLVDMEVEVRMNSELIVRQMQGVYKVKEPTLKEKFAKIAHIKMERVPNLVFVHIPREKNARADELVNEAIDKALS 4h8k A 2.30 BS02 NUC D 1 N15 T44 N45 N46 L80 Q84 Y89 K90 V91 K92 E93 L96 N13 T42 N43 N44 L78 Q82 Y87 K88 V89 K90 E91 L94 3.1.26.4 E0X767 23500886 KIIIYTDGGARGNPGPAGIGVVITDEKGNTLHESSAYIGETTNNVAEYEALIRALEDLQMFGDKLVDMEVEVRMNSELIVRQMQGVYKVKEPTLKEKFAKIAHIKMERVPNLVFVHIPREKNARADELVNEAIDKALS 4h8k B 2.30 BS01 NUC C 1 G10 G11 A12 R13 G14 N15 N45 N77 E79 G8 G9 A10 R11 G12 N13 N43 N75 E77 3.1.26.4 E0X767 23500886 KIIIYTDGGARGNPGPAGIGVVITDEKGNTLHESSAYIGETTNNVAEYEALIRALEDLQMFGDKLVDMEVEVRMNSELIVRQMQGVYKVKEPTLKEKFAKIAHIKMERVPNLVFVHIPREKNARADELVNEAIDKALS 4h8u A 2.00 BS01 SUC A 1 D61 Y64 H104 F145 F164 Q168 T201 E254 F256 F280 R284 H326 D327 E386 R414 D58 Y61 H101 F142 F161 Q165 T198 E251 F253 F277 R281 H323 D324 E383 R411 5.4.11.99 Q2PS28 APWWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYDISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDNPYRDYYFWRDGKDGHEPNNYPSFFGGSAWEKDPVTGQYYLHYFGRQQPDLNWDTPKLREELYAMLRFWLDKGVSGMRFATVATYSKTPGFPDLTPEQMKNFAEAYTQGPNLHRYLQEMHEKVFDHYDAVTAGEIFGAPLNQVPLFIDSRRKELDMAFTFDLIRYDRALDRWHTIPRTLADFRQTIDKVDAIAGEYGWNTFFLGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTPFIFQGDELGMTNYPFKTLQDFDDIEVKGFFQDYVETGKATAEELLTNVALTSRNNARTPFQWDDSANAGFTTGKPWLKVNPNYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSYRDIDPSNADVYAYTRSQDGETYLVVVNFKAEPRSFTLPDGMHIAETLIESSSPAAPAAGAASLELQPWQSGIYKVK 4h8u B 2.00 BS01 TEU B 1 D61 Y64 H104 F145 F164 Q168 R198 E254 F256 R284 R291 H326 D327 E386 R414 D58 Y61 H101 F142 F161 Q165 R195 E251 F253 R281 R288 H323 D324 E383 R411 5.4.11.99 Q2PS28 APWWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYDISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDNPYRDYYFWRDGKDGHEPNNYPSFFGGSAWEKDPVTGQYYLHYFGRQQPDLNWDTPKLREELYAMLRFWLDKGVSGMRFATVATYSKTPGFPDLTPEQMKNFAEAYTQGPNLHRYLQEMHEKVFDHYDAVTAGEIFGAPLNQVPLFIDSRRKELDMAFTFDLIRYDRALDRWHTIPRTLADFRQTIDKVDAIAGEYGWNTFFLGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTPFIFQGDELGMTNYPFKTLQDFDDIEVKGFFQDYVETGKATAEELLTNVALTSRNNARTPFQWDDSANAGFTTGKPWLKVNPNYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSYRDIDPSNADVYAYTRSQDGETYLVVVNFKAEPRSFTLPDGMHIAETLIESSSPAAPAAGAASLELQPWQSGIYKVK 4h8v A 1.95 BS02 TEU A 1 D61 Y64 H104 F145 F164 R198 D200 E254 F256 R284 R291 H326 D327 E386 R414 D61 Y64 H104 F145 F164 R198 D200 E254 F256 R284 R291 H326 D327 E386 R414 5.4.11.99 Q2PS28 KPGAPWWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYDISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDNPYRDYYFWRDGKDGHEPNNYPSFFGGSAWEKDPVTGQYYLHYFGRQQPDLNWDTPKLREELYAMLRFWLDKGVSGMRFDTVATYSKTPGFPDLTPEQMKNFAEAYTQGPNLHRYLQEMHEKVFDHYDAVTAGEIFGAPLNQVPLFIDSRRKELDMAFTFDLIRYDRALDRWHTIPRTLADFRQTIDKVDAIAGEYGWNTFFLGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTPFIFQGDELGMTNYPFKTLQDFDDIEVKGFFQDYVETGKATAEELLTNVALTSRDNARTPFQWDDSANAGFTTGKPWLKVNPNYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSYRDIDPSNADVYAYTRSQDGETYLVVVNFKAEPRSFTLPDGMHIAETLIESSSPAAPAAGAASLELQPWQSGIYKVK 4h8v B 1.95 BS02 TEU B 1 D61 Y64 H104 F144 F145 F164 Q168 R198 D200 T201 E254 F256 H326 D327 E386 R414 D61 Y64 H104 F144 F145 F164 Q168 R198 D200 T201 E254 F256 H326 D327 E386 R414 5.4.11.99 Q2PS28 KPGAPWWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYDISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDNPYRDYYFWRDGKDGHEPNNYPSFFGGSAWEKDPVTGQYYLHYFGRQQPDLNWDTPKLREELYAMLRFWLDKGVSGMRFDTVATYSKTPGFPDLTPEQMKNFAEAYTQGPNLHRYLQEMHEKVFDHYDAVTAGEIFGAPLNQVPLFIDSRRKELDMAFTFDLIRYDRALDRWHTIPRTLADFRQTIDKVDAIAGEYGWNTFFLGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTPFIFQGDELGMTNYPFKTLQDFDDIEVKGFFQDYVETGKATAEELLTNVALTSRDNARTPFQWDDSANAGFTTGKPWLKVNPNYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSYRDIDPSNADVYAYTRSQDGETYLVVVNFKAEPRSFTLPDGMHIAETLIESSSPAAPAAGAASLELQPWQSGIYKVK 4ha1 A 2.20 BS02 ISL A 1 D61 Y64 H104 F145 F164 Q168 E254 R284 H326 D327 E386 R414 D60 Y63 H103 F144 F163 Q167 E253 R283 H325 D326 E385 R413 5.4.11.99 Q2PS28 PGAPWWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYDISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDNPYRDYYFWRDGKDGHEPNNYPSFFGGSAWEKDPVTGQYYLHYFGRQQPDLNWDTPKLREELYAMLRFWLDKGVSGMRFATVATYSKTPGFPDLTPEQMKNFAEAYTQGPNLHRYLQEMHEKVFDHYDAVTAGEIFGAPLNQVPLFIDSRRKELDMAFTFDLIRYDRALDRWHTIPRTLADFRQTIDKVDAIAGEYGWNTFFLGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTPFIFQGDELGMTNYPFKTLQDFDDIEVKGFFQDYVETGKATAEELLTNVALTSRNNARTPFQWDDSANAGFTTGKPWLKVNPNYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSYRDIDPSNADVYAYTRSQDGETYLVVVNFKAEPRSFTLPDGMHIAETLIESSSPAAPAAGAASLELQPWQSGIYKVK 4hi1 A 1.96 BS01 MOO A 1 G16 V17 G18 F19 R20 Y21 G13 V14 G15 F16 R17 Y18 3.6.1.7 A5F8G9 QCSKFIVSGHVQGVGFRYHTSHQGLKLGLTGYAKNLNNGDVEVVACGTPERLEELYLWLQEGPKTASVRQVRRLSSELEHDYQGFEIL 4hi1 B 1.96 BS01 MOO B 1 G18 F19 R20 Y21 G15 F16 R17 Y18 3.6.1.7 A5F8G9 QCSKFIVSGHVQGVGFRYHTSHQGLKLGLTGYAKNLNNGDVEVVACGTPERLEELYLWLQEGPKTASVRQVRRLSSDYQGFEIL 4hi1 C 1.96 BS01 MOO C 1 G16 V17 G18 F19 R20 Y21 I90 G12 V13 G14 F15 R16 Y17 I86 3.6.1.7 A5F8G9 CSKFIVSGHVQGVGFRYHTSHQGLKLGLTGYAKNLNNGDVEVVACGTPERLEELYLWLQEGPKTASVRQVRRLSSELEHDYQGFEIL 4iea A 1.70 BS01 III P 1 K49 N50 R56 R60 K122 R129 Y130 G171 L174 N175 V178 E182 L218 L222 N226 L229 W230 K53 N54 R60 R64 K121 R128 Y129 G170 L173 N174 V177 E181 L217 L221 N225 L228 W229 P31947 23808890 AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 4ihl A 2.20 BS01 III P 1 V46 K49 N50 R56 K120 R127 Y128 G169 L172 N173 V176 E180 L220 N224 L227 W228 V46 K49 N50 R56 K120 R127 Y128 G169 L172 N173 V176 E180 L220 N224 L227 W228 P63104 23808890 MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS 4ihl A 2.20 BS02 1F5 A 1 N42 L43 F117 K120 M121 P165 I166 D213 N42 L43 F117 K120 M121 P165 I166 D213 P63104 23808890 MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS 4ihl B 2.20 BS01 III P 2 K49 R56 K120 R127 Y128 G169 L172 N173 V176 E180 L220 N224 L227 K49 R56 K118 R125 Y126 G166 L169 N170 V173 E177 L217 N221 L224 P63104 23808890 MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS 4ihl B 2.20 BS02 1F5 B 1 N42 L43 F117 K120 M121 P165 I166 D213 I217 N42 L43 F115 K118 M119 P162 I163 D210 I214 P63104 23808890 MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS 4irp A 2.10 BS01 UDP A 1 P100 F101 R102 R104 F139 D163 V164 D165 Y194 P24 F25 R26 R28 F63 D87 V88 D89 Y118 2.4.1.-,2.4.1.133 Q9UBV7 GSDIPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLHFKVDREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS 4irp A 2.10 BS02 MN A 1 D165 H257 H259 D89 H181 H183 2.4.1.-,2.4.1.133 Q9UBV7 GSDIPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLHFKVDREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS 4irp B 2.10 BS01 UDP B 1 P100 F101 R102 R104 F139 D163 V164 D165 Y194 P24 F25 R26 R28 F63 D87 V88 D89 Y118 2.4.1.-,2.4.1.133 Q9UBV7 GSDIPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS 4irp B 2.10 BS02 MN B 1 D165 H257 D89 H181 2.4.1.-,2.4.1.133 Q9UBV7 GSDIPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS 4irq A 2.30 BS02 UDP A 1 P100 F101 R102 R104 F139 D163 V164 D165 Y194 W224 H257 H259 R266 P19 F20 R21 R23 F58 D82 V83 D84 Y113 W143 H176 H178 R185 2.4.1.-,2.4.1.133 Q9UBV7 EHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKVDREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS 4irz A 2.84 BS04 NDS A 1 Y21 T97 I169 S170 S171 Y220 V222 Y21 T97 I169 S170 S171 Y220 V222 YNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKASTEEFPPLQPILQQKKEKDIMKKTINFARTGGLE 4itc A 1.55 BS01 CA A 1 D1001 D1003 D1005 H1007 N1043 D20 D22 D24 H26 N62 3.4.22.47 Q51817 GTTLSESFENGIPASWKTIDADGDGHGWKPGNAPGIAGYNSNGCVYSESFGLGGIGVLTPDNYLITPALDLPNGGKLTFWVCAQDANYASEHYAVYASSTGNDASNFTNALLEETITAKPKAIRGRIQGTWRQKTVDLPAGTKYVAFRHFQSTDMFYIDLDEVEIKANG 4itc A 1.55 BS02 CA A 2 S988 E990 S1022 G1024 D1146 E1147 S7 E9 S41 G43 D161 E162 3.4.22.47 Q51817 GTTLSESFENGIPASWKTIDADGDGHGWKPGNAPGIAGYNSNGCVYSESFGLGGIGVLTPDNYLITPALDLPNGGKLTFWVCAQDANYASEHYAVYASSTGNDASNFTNALLEETITAKPKAIRGRIQGTWRQKTVDLPAGTKYVAFRHFQSTDMFYIDLDEVEIKANG 4j3y A 1.45 BS01 ZN A 1 C200 C203 H220 C227 C50 C53 H70 C77 6.3.2.- P98170 GTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGR 4j44 A 1.30 BS01 III B 1 K206 L207 K208 N209 W210 D214 E219 R222 H223 F224 K56 L57 K58 N59 W60 D64 E69 R72 H73 F74 6.3.2.- P98170 23999295 GTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGR 4j45 A 1.48 BS01 III B 1 Q197 K206 L207 K208 N209 W210 D214 E219 R222 H223 Q47 K56 L57 K58 N59 W60 D64 E69 R72 H73 6.3.2.- P98170 23999295 GTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGR 4j46 A 1.42 BS01 III B 1 Q197 K206 L207 K208 N209 W210 D214 E219 H223 F224 Q47 K56 L57 K58 N59 W60 D64 E69 H73 F74 6.3.2.- P98170 23999295 GTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGR 4jf4 A 2.14 BS01 MER A 1 A78 S79 F110 W113 L125 S126 V128 T217 G218 W219 M221 A256 R259 A47 S48 F79 W82 L94 S95 V97 T186 G187 W188 M190 A225 R228 3.5.2.6 Q9L4P2 24012371 IVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII 4jf4 B 2.14 BS01 MER B 1 A78 S79 F110 W113 S126 V128 L166 T217 G218 W219 M221 A256 R259 A46 S47 F78 W81 S94 V96 L134 T185 G186 W187 M189 A224 R227 3.5.2.6 Q9L4P2 24012371 VQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII 4jfx H 1.95 BS01 III P 1 G33 V52 T52A G53 R55 K56 Y58 S98 T99 S100 Y100A G33 V52 T53 G54 R56 K57 Y59 S102 T103 S104 Y105 23955275 EVQLVESGGGLVQPGGSLRLSCVTSGFTFRKFGMSWVRQAPGKGLEWVASIVTGGRKTYYSDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGYSSTSYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS 4krg A 1.68 BS01 OPE A 1 M26 M27 W123 M126 Y127 S155 P159 S160 H170 Y180 M32 M33 W129 M132 Y133 S161 P165 S166 H176 Y186 24012478 LYFQGHMTAEVRRDSFKTFWDKYSDKPDTNSMMLNQTAQDLEASDRADILSSLPHLTNKDVVDIGAGIGRFTTVLAETARWVLSTDFIESFIEKNQERNAHMGNISYQIGDAVHLQMDEKSVDLVFTNWLMMYLSDREVIEFLLNAMRWLRADGYIHLRESCSEPSTGRLKTATMHSAVDANPTHYRFSSLYIKLLRAIRYRDSDGKMWKFDVQWSCSVPTYIRRCNNWRQVHWLTKKVPAVGDEETSVDDLLNLFSQIWPAEQKTWDEKLDNEKYSWTDKIFSNAIDDEVVPKNSTAYVFTPRQRSPFLHVNSHLLAEKFTCNVWNVETKEYLYRTSLTKANNQKDQRVRFGWNESLSSSIDYWNQRDASFDCMVATELLATCDDESINSIASIMKPEAKVVLLEPVSGIDETSVRQRMTTCGFKNITIVDVTQESLNAEVSFIKDHNLDVELSGCNYLLIKASL 4krg A 1.68 BS02 SAH A 1 R7 W14 M26 G59 G61 R64 F65 D80 F81 I82 F85 G104 D105 A106 N122 W123 L124 R13 W20 M32 G65 G67 R70 F71 D86 F87 I88 F91 G110 D111 A112 N128 W129 L130 24012478 LYFQGHMTAEVRRDSFKTFWDKYSDKPDTNSMMLNQTAQDLEASDRADILSSLPHLTNKDVVDIGAGIGRFTTVLAETARWVLSTDFIESFIEKNQERNAHMGNISYQIGDAVHLQMDEKSVDLVFTNWLMMYLSDREVIEFLLNAMRWLRADGYIHLRESCSEPSTGRLKTATMHSAVDANPTHYRFSSLYIKLLRAIRYRDSDGKMWKFDVQWSCSVPTYIRRCNNWRQVHWLTKKVPAVGDEETSVDDLLNLFSQIWPAEQKTWDEKLDNEKYSWTDKIFSNAIDDEVVPKNSTAYVFTPRQRSPFLHVNSHLLAEKFTCNVWNVETKEYLYRTSLTKANNQKDQRVRFGWNESLSSSIDYWNQRDASFDCMVATELLATCDDESINSIASIMKPEAKVVLLEPVSGIDETSVRQRMTTCGFKNITIVDVTQESLNAEVSFIKDHNLDVELSGCNYLLIKASL 4krg B 1.68 BS01 OPE B 1 M26 M27 L28 W123 M126 Y127 S155 P159 S160 H170 Y180 M32 M33 L34 W129 M132 Y133 S161 P165 S166 H176 Y186 24012478 LYFQGHMTAEVRRDSFKTFWDKYSDKPDTNSMMLNQTAQDLEASDRADILSSLPHLTNKDVVDIGAGIGRFTTVLAETARWVLSTDFIESFIEKNQERNAHMGNISYQIGDAVHLQMDEKSVDLVFTNWLMMYLSDREVIEFLLNAMRWLRADGYIHLRESCSEPSTGRLKTATMHSAVDANPTHYRFSSLYIKLLRAIRYRDSDGKMWKFDVQWSCSVPTYIRRCNNWRQVHWLTKKVPAVGDEETSVDDLLNLFSQIWPAEQKTWDEKLDNEKYSWTDKIFSNAIDDEVVPKNSTAYVFTPRQRSPFLHVNSHLLAEKFTCNVWNVETKEYLYRTSLTKANNQKDQRVRFGWNESLSSSIDYWNQRDASFDCMVATELLATCDDESINSIASIMKPEAKVVLLEPVSGIDETSVRQRMTTCGFKNITIVDVTQESLNAEVSFIKDHNLDVELSGCNYLLIKASL 4krh A 3.00 BS01 SAM A 1 F174 Y183 I200 S201 G228 G230 D250 L251 S252 M255 C276 D277 A278 R294 D295 C296 H299 I300 F173 Y182 I199 S200 G227 G229 D249 L250 S251 M254 C275 D276 A277 R293 D294 C295 H298 I299 24012478 ASMPAVERQLIECLHHVIKGAEPQQVGILCPQDDQRKALTEQFGSKTATSFCKEVDSLKNLSNLDALIVNQALDEEINDSEKLDKFITAALRSLRTDGVLILRQDLSKVKEMKKMAMLTDYFDVFRLEEGNGNVGFQFYAVNEVLDSVYVHQNWLDFIWTLMKKPFPKGVVSFRDFLDRTQYTDTGIFAYEWIFGNNFISPGGWNQNLAILKRFGPMKTGQRMLDIGVGIGGGARQAASEFGLQVHGVDLSTNMLAVALERVHKEKDARVTYAVCDACEYEFEPNSFDYVFSRDCIQHIKDTDKLFSRIYRALKPGGKVLITMYGVGHGTLSESFKEYVSQRQYYLKNLEQIEEIAKKTGFIDIEVENMTPRFKEILLEERERIEQDKETFLAKFSQNAYDGLVSGWKSKLQYIADDNHNWNFFAAVKPQ 4krh B 3.00 BS01 SAM B 1 F174 Y183 F199 I200 S201 G228 D250 L251 S252 M255 C276 D277 A278 R294 D295 C296 H299 F173 Y182 F198 I199 S200 G227 D249 L250 S251 M254 C275 D276 A277 R293 D294 C295 H298 24012478 ASMPAVERQLIECLHHVIKGAEPQQVGILCPQDDQRKALTEQFGSKTATSFCKEVDSLKNLSNLDALIVNQALDEEINDSEKLDKFITAALRSLRTDGVLILRQDLSKVKEMKKMAMLTDYFDVFRLEEGNGNVGFQFYAVNEVLDSVYVHQNWLDFIWTLMKKPFPKGVVSFRDFLDRTQYTDTGIFAYEWIFGNNFISPGGWNQNLAILKRFGPMKTGQRMLDIGVGIGGGARQAASEFGLQVHGVDLSTNMLAVALERVHKEKDARVTYAVCDACEYEFEPNSFDYVFSRDCIQHIKDTDKLFSRIYRALKPGGKVLITMYGVGHGTLSESFKEYVSQRQYYLKNLEQIEEIAKKTGFIDIEVENMTPRFKEILLEERERIEQDKETFLAKFSQNAYDGLVSGWKSKLQYIADDNHNWNFFAAVKPQ 4kri A 1.72 BS02 1SH A 1 Q182 Y191 I200 Q298 Y325 Y339 R343 Y345 K411 Q180 Y189 I198 Q296 Y323 Y337 R341 Y343 K409 24012478 ASMPAVERQLIECLHHVIKGAEPQQVGILCPQDDQRKALTEQFGSKTATSFCKEVDSLKNLSNLDALIVNQALDEEINDSEKLDKFITAALRSLRTDGVLILRQDLSKVKEMKKMAMLTDYFDVFRLEEGNGNVGFQFYAVNEVLDSVYVHQNWLDFIWTLMKKPFPKVVSFRDFLDRTQYTDTGIFAYEWIFGNNFISPGGWNQNLAILKRFGPMKTGQRMLDIGVGIGGGARQAASEFGLQVHGVDLSTNMLAVALERVHKEKDARVTYAVCDACEYEFEPNSFDYVFSRDCIQHIKDTDKLFSRIYRALKPGGKVLITMYGVGHGTLSESFKEYVSQRQYYLKNLEQIEEIAKKTGFIDIEVENMTPRFKEILLEERERIEQDKETFLAKFSQNAYDGLVSGWKSKLQYIADDNHNWNFFAAVKPQ 4kri C 1.72 BS02 1SH C 1 Q182 Y183 Y191 I200 D295 Y325 Y339 R343 Y345 K411 Q178 Y179 Y187 I196 D291 Y321 Y335 R339 Y341 K407 24012478 ASMPAVERQLIECLHHVIKGAEPQQVGILCPQDDQRKALTEQFGSKTATSFCKEVDSLKNLSNLDALIVNQALDEEINDSEKLDKFITAALRSLRTDGVLILRQDLSKVKEMKKMAMLTDYFDVFRLEEGNGNVGFQFYAVNEVLDSVYVHQNWLDFIWTLMKKPFPVSFRDFLDRTQYTDTGIFAYEWIFGNNFISPGGWNQNLAILKRFGPMKTGQRMLDIGVGIGGGARQAASEFGLQVHGVDLSTNMLAVALERVHKEKDARVTYAVCDACEYEFEPNSFDYVFSRDCIQHIKDTDKLFSRIYRALKPGGKVLITMYGVGHGTLSESFKEYVSQRQYYLKNLEQIEEIAKKTGFIDIEVENMTPRFKEILLEERERIEQDKETFLAKFSQNAYDGLVSGWKSKLQYIADDNHNWNFFAAVKPQ 4kyc A 1.95 BS01 MAL A 1 N12 D14 K15 W62 A63 D65 R66 E111 E153 P154 Y155 W230 W340 N12 D14 K15 W62 A63 D65 R66 E111 E153 P154 Y155 W230 W340 Q91MK1 23963781 KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAAQTNAAASGYKMTLLALIKESIPNQAKRQKFEMQVGGIRNEQDFKNLRREIIRSAAQ 4kye A 2.60 BS01 MAL A 1 D14 K15 W62 A63 D65 R66 E111 E153 P154 Y155 F156 W230 W340 R344 D14 K15 W62 A63 D65 R66 E111 E153 P154 Y155 F156 W230 W340 R344 P21738 23963781 KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAAQTNAAADALKITVSEMIRDLFGDSDKSRKLLESINM 4l0e A 2.70 BS01 HEM A 1 Y66 N78 L95 A96 H103 R107 I158 L244 G247 G248 T251 S255 L288 P293 F297 R299 T349 F350 G351 P354 H355 C357 L358 G359 Y88 N100 L117 A118 H125 R129 I180 L264 G267 G268 T271 S275 L308 P313 F317 R319 T369 F370 G371 P374 H375 C377 L378 G379 1.14.-.- F2YRY7 GSSHHHHHHSSGLVPRGSHSGHMTAHTLPIPDDISTINLTDPRTYEVNDLSEYWRQLRTTRPLYWHPPVGDAPGFWVVSRYADVMALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKSFSPQALKPIVDQIRVNTTRLVVDAARRGECDFAADVAEQIPLNTISDLLGVPAADREFLLKLNKSALSSEDQSATDAWLARNEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTEEVIVLNCYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVTLESATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNRSPNKHITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEPQRIHSNFLTGLSRLPVRIQPNEAAIAAYDSDNG 4l0f A 1.90 BS01 HEM A 1 Y66 N78 L95 A96 H103 R107 F114 L161 S243 L244 G247 G248 T251 S252 S255 L288 P293 F297 R299 T349 F350 G351 H355 C357 L358 G359 Y81 N93 L110 A111 H118 R122 F129 L176 S257 L258 G261 G262 T265 S266 S269 L302 P307 F311 R313 T363 F364 G365 H369 C371 L372 G373 1.14.-.- F2YRY7 HHSSGLVPRGSHSGHMTAHTLPIPDDISTINLTDPRTYEVNDLSEYWRQLRTTRPLYWHPPVGDAPGFWVVSRYADVMALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKSFSPQALKPIVDQIRVNTTRLVVDAARRGECDFAADVAEQIPLNTISDLLGVPAADREFLLKLNKSALSSEADQSATDAWLARNEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTEEVIVLNCYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVTLESATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNRSPNKHITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEPQRIHSNFLTGLSRLPVRIQPNEAAIAAYDSDNGVRS 4lde A 2.79 BS01 P0G A 1 W1109 D1113 V1114 V1117 C1191 F1193 A1200 S1203 S1207 F1289 F1290 N1293 Y1308 I1309 N1312 Y1316 W252 D256 V257 V260 C334 F336 A343 S346 S350 F401 F402 N405 Y420 I421 N424 Y428 3.2.1.17 P07550 DAENLYFQGNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKFALKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 4lde A 2.79 BS02 1WV A 1 M1040 I1043 I1094 I1309 W1313 M183 I186 I237 I421 W425 3.2.1.17 P07550 DAENLYFQGNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKFALKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 4ldl A 3.10 BS01 XQC A 1 W1109 D1113 V1117 C1191 D1192 F1193 S1203 S1207 F1289 F1290 Y1308 I1309 N1312 Y1316 W252 D256 V260 C334 D335 F336 S346 S350 F401 F402 Y420 I421 N424 Y428 3.2.1.17 P07550 DAENLYFQGNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKFALKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 4ldl A 3.10 BS02 1WV A 1 M1040 E1306 W1313 M183 E418 W425 3.2.1.17 P07550 DAENLYFQGNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKFALKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 4ldo A 3.20 BS01 1WV A 1 M1040 I1094 W1313 M183 I237 W425 3.2.1.17 P07550 DAENLYFQGNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKFALKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 4ldo A 3.20 BS02 ALE A 1 D1113 V1114 V1117 S1203 S1207 F1289 N1293 N1312 Y1316 D256 V257 V260 S346 S350 F401 N405 N424 Y428 3.2.1.17 P07550 DAENLYFQGNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKFALKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 4lg6 A 1.80 BS01 III B 1 F183 W188 A191 E216 L221 D245 G249 Y254 H257 S280 Y282 L287 A290 F36 W41 A44 E69 L74 D98 G102 Y107 H110 S133 Y135 L140 A143 Q9H9E1 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQN 4lv5 A 1.70 BS01 ADP A 1 R241 G243 D244 S246 V248 A261 K263 M337 P338 A340 D343 D393 F396 R67 G69 D70 S72 V74 A87 K89 M149 P150 A152 D155 D205 F208 F2YGR7 EAGDSFMRDLLKREEELIGYCREEALKEPAAMVEAVTATVWPQNAETTVDSLLSQGERKLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSLS 4lv5 B 1.70 BS01 GDP B 1 G79 S80 G81 K82 S83 S84 T102 K184 D186 S187 S231 N232 K233 G66 S67 G68 K69 S70 S71 T89 K171 D173 S174 S218 N219 K220 3.6.5.- Q9QZ85 NDLPSSFTGYFKKFNTGRKIISQEILNLIELRMRKGNIQLTNSAISDALKEIDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKTGVVEVTMERHPYKHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRFKKNDIDIAKAISMMKKEFYFVRTKVDSDITNEADGKPQTFDKEKVLQDIRLNCVNTFRENGIAEPPIFLLSNKNVCHYDFPVLMDKLISDLPIYKRHNFMVSLPNITDSVIEKKRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYRTVFGVDETSLQRLARDWEIEVDQVEAMIKSPAVFKPEETIQERLSRYIQEFCLANGYLLPKNSFLKEIFYLKYYFLDMVTEDAKTLLKEICL 4lv9 A 1.81 BS01 20J A 1 F193 D219 S241 V242 A244 A245 S275 R311 F176 D202 S224 V225 A227 A228 S258 R294 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIEL 4lv9 A 1.81 BS02 20J A 2 Y188 H191 Y240 S241 V242 I309 R349 A379 Y171 H174 Y223 S224 V225 I292 R332 A362 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIEL 4lv9 B 1.81 BS01 20J B 1 F193 D219 S241 V242 A244 A245 R311 F176 D202 S224 V225 A227 A228 R294 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEA 4lva A 1.55 BS01 20M A 1 Y188 H191 F193 R196 D219 S241 V242 A244 A245 S275 I309 R311 I351 A379 Y171 H174 F176 R179 D202 S224 V225 A227 A228 S258 I292 R294 I334 A362 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIEL 4lvb A 1.84 BS01 20N A 1 H191 F193 A244 A245 S275 I309 R311 I351 A379 H175 F177 A228 A229 S259 I293 R295 I335 A363 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 4lvb B 1.84 BS01 20N B 1 H191 F193 A244 A245 S275 R311 I351 A379 H175 F177 A228 A229 S259 R295 I335 A363 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIEL 4lvd B 1.75 BS01 1EB B 1 H191 F193 R196 D219 S241 V242 A244 R311 H174 F176 R179 D202 S224 V225 A227 R294 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIEL 4lvf A 1.50 BS01 20P A 1 H191 F193 R196 D219 V242 A244 A245 S275 I309 R311 I351 H174 F176 R179 D202 V225 A227 A228 S258 I292 R294 I334 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIEL 4lvg A 1.70 BS01 20O A 1 Y188 H191 F193 R196 D219 V242 A244 A245 P273 S275 R311 I351 A379 Y171 H174 F176 R179 D202 V225 A227 A228 P256 S258 R294 I334 A362 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIEL 4lvg B 1.70 BS01 20O B 1 Y188 H191 F193 R196 D219 V242 A244 P273 S275 I309 R311 I351 A379 Y171 H174 F176 R179 D202 V225 A227 P256 S258 I292 R294 I334 A362 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 4lw3 A 2.00 BS02 GDU A 1 P82 F83 R84 R86 F121 R123 D145 V146 D147 Y177 G185 W207 G208 E210 N211 H241 H243 R250 P13 F14 R15 R17 F52 R54 D76 V77 D78 Y108 G116 W138 G139 E141 N142 H172 H174 R181 2.4.1.-,2.4.1.133 Q9VBZ9 DGASVHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRFRFNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIAGPKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLENDEFFVRIRDAGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKTGLDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS 4lw6 A 2.40 BS01 MN A 1 D147 H241 H243 R250 D74 H168 H170 R177 2.4.1.-,2.4.1.133 Q9VBZ9 VHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRFRFNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIAGPKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLEDDEFFVRIRDAGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKTGLDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS 4lw6 A 2.40 BS03 XYP A 1 Y177 Y179 F182 W207 G208 L209 D211 D212 Y104 Y106 F109 W134 G135 L136 D138 D139 2.4.1.-,2.4.1.133 Q9VBZ9 VHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRFRFNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIAGPKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLEDDEFFVRIRDAGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKTGLDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS 4lw6 A 2.40 BS04 SEL A 1 R123 D145 G185 W207 G208 E210 R50 D72 G112 W134 G135 E137 2.4.1.-,2.4.1.133 Q9VBZ9 VHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRFRFNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIAGPKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLEDDEFFVRIRDAGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKTGLDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS 4m44 A 2.50 BS01 SIA A 1 R136 G138 T139 S140 G141 D193 L201 Q239 S240 R136 G138 T139 S140 G141 D195 L203 Q241 S242 A3DQM7 DRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPTCLNCTDLDVALGRPMCVGVTPSAKASILHEVRPVTSGCFPIMHDRTKIRQLPNLLRGYEKIRLSTQNVINAEKAPGGPYRLGTSGSCPNATSRSGFFATMAWAVPKDNNKTATNPLTVEVPHICTKEEDQITVWGFHSDDKTQMKNLYGDSNPQKFTSSANGVTTHYVSQIGGFPDQTEDGGLPQSGRIVVDYMVQKPGKTGTIVYQRGILLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLL 4m44 E 2.50 BS01 SIA E 1 R136 G138 T139 S140 G141 W158 D193 L201 Q239 S240 R136 G138 T139 S140 G141 W158 D195 L203 Q241 S242 A3DQM7 DRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPTCLNCTDLDVALGRPMCVGVTPSAKASILHEVRPVTSGCFPIMHDRTKIRQLPNLLRGYEKIRLSTQNVINAEKAPGGPYRLGTSGSCPNATSRSGFFATMAWAVPKDNNKTATNPLTVEVPHICTKEEDQITVWGFHSDDKTQMKNLYGDSNPQKFTSSANGVTTHYVSQIGGFPDQTEDGGLPQSGRIVVDYMVQKPGKTGTIVYQRGILLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLL 4m4k A 2.20 BS03 XYP A 1 Y177 Y179 F182 W207 G208 L209 N211 D212 Y104 Y106 F109 W134 G135 L136 N138 D139 2.4.1.-,2.4.1.133 Q9VBZ9 VHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRFRFNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIAGPKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLENDEFFVRIRDAGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKTGLDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS 4m4k A 2.20 BS04 XYP A 2 Y177 W207 Y104 W134 2.4.1.-,2.4.1.133 Q9VBZ9 VHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRFRFNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIAGPKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLENDEFFVRIRDAGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKTGLDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS 4m5u A 2.20 BS02 MN A 2 H41 E80 P107 D108 H46 E85 P112 D113 F0TRT1 GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE 4m5u A 2.20 BS04 20F A 1 A20 Y24 K34 A37 I38 H41 E80 D108 E119 I120 R124 K134 A25 Y29 K39 A42 I43 H46 E85 D113 E124 I125 R129 K139 F0TRT1 GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE 4m6j A 1.20 BS01 NDP A 1 V8 A9 I16 G17 G20 D21 L22 G53 K54 K55 T56 L75 S76 R77 E78 R91 S92 V115 G117 S118 S119 V120 Y121 V6 A7 I14 G15 G18 D19 L20 G51 K52 K53 T54 L73 S74 R75 E76 R89 S90 V113 G115 S116 S117 V118 Y119 1.5.1.3 P00374 SLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 4m6k A 1.40 BS01 FOL A 1 I7 V8 A9 L22 E30 F31 R32 F34 Q35 N64 L67 R70 V115 I7 V8 A9 L22 E30 F31 R32 F34 Q35 N64 L67 R70 V115 1.5.1.3 P00374 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 4m6k A 1.40 BS02 NAP A 1 V8 A9 I16 G17 G20 D21 L22 G53 K54 K55 T56 L75 S76 R77 E78 R91 V115 G117 S118 Y121 T146 V8 A9 I16 G17 G20 D21 L22 G53 K54 K55 T56 L75 S76 R77 E78 R91 V115 G117 S118 Y121 T146 1.5.1.3 P00374 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 4m6l A 1.70 BS01 21V A 1 I7 V8 A9 L22 E30 F31 F34 Q35 T56 I60 N64 L67 R70 V115 Y121 T136 I7 V8 A9 L22 E30 F31 F34 Q35 T56 I60 N64 L67 R70 V115 Y121 T136 1.5.1.3 P00374 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 4m6l A 1.70 BS02 NAP A 1 V8 A9 I16 G17 G20 D21 L22 G53 K54 K55 T56 L75 S76 R77 E78 R91 V115 G116 G117 S118 S119 V120 Y121 E123 T146 V8 A9 I16 G17 G20 D21 L22 G53 K54 K55 T56 L75 S76 R77 E78 R91 V115 G116 G117 S118 S119 V120 Y121 E123 T146 1.5.1.3 P00374 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 4m6p A 1.75 BS01 20R A 1 Y188 H191 F193 R196 D219 S241 V242 A244 S275 R311 I351 Y172 H175 F177 R180 D203 S225 V226 A228 S259 R295 I335 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEA 4m6q A 2.41 BS01 20T A 1 Y188 H191 F193 R196 G217 D219 Y240 S241 V242 A244 S275 I309 R311 D313 I351 G353 G383 G384 Y172 H175 F177 R180 G201 D203 Y224 S225 V226 A228 S259 I293 R295 D297 I335 G337 G367 G368 2.4.2.12 P43490 24021463 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 4m7c A 2.05 BS01 III C 1 R80 M83 Q84 L87 V88 L91 K93 S98 L101 R102 M104 Q105 S108 R109 E112 S119 F120 D121 M122 R35 M38 Q39 L42 V43 L46 K48 S53 L56 R57 M59 Q60 S63 R64 E67 S74 F75 D76 M77 Q15554 24012755 ARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKAL 4m8u A 1.45 BS01 CA A 1 D20 N22 D24 F26 D28 D19 N21 D23 F25 D27 3.2.1.10 O06994 24015933 SEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGADVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNHTSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYLHYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDAIGSISKYTDFPDYETDHSRSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELNMIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQPRVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKNAYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQDINVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLLVVVNLSEEKALFEAPPELIHERWKVLISNYPERADLKSISLKPYEAVMGISI 4mcd A 1.55 BS01 22L A 1 L87 S88 P89 G113 S132 I133 G134 Y136 L138 T139 G140 P144 L87 S88 P89 G113 S132 I133 G134 Y136 L138 T139 G140 P144 2.1.1.228 P43912 23981144 MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4men A 1.81 BS01 25K A 1 W81 P82 F83 V87 L92 L94 Y139 N140 D145 I146 M149 W40 P41 F42 V46 L51 L53 Y98 N99 D104 I105 M108 O60885 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4meo A 1.72 BS01 25V A 1 W81 P82 F83 Q85 P86 V87 D88 L92 L94 N140 I146 W40 P41 F42 Q44 P45 V46 D47 L51 L53 N99 I105 O60885 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4mep A 1.85 BS01 24Y A 1 W81 P82 F83 Q85 V87 L92 N140 W40 P41 F42 Q44 V46 L51 N99 O60885 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4meq A 1.77 BS01 25O A 1 W81 P82 F83 V87 L92 L94 Y139 N140 I146 W40 P41 F42 V46 L51 L53 Y98 N99 I105 O60885 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4mhd A 2.32 BS01 SPD A 1 E33 Y36 E41 E32 Y35 E40 Q9KL03 NSQLTLRALERGDLRFIHNLNNNRNIMSYWFEEPYESFDELEELYNKHIHDNAERRFVVEDAQKNLIGLVELIEINYIHRSAEFQIIIAPEHQGKGFARTLINRALDYSFTILNLHKIYLHVAVENPKAVHLYEECGFVEEGHLVEEFFINGRYQDVKRMYILQSKYLNR 4mhd B 2.32 BS01 SPD B 1 E33 E34 E37 E41 E32 E33 E36 E40 Q9KL03 NSQLTLRALERGDLRFIHNLNNNRNIMSYWFEEPYESFDELEELYNKHIHDNAERRFVVEDAQKNLIGLVELIEINYIHRSAEFQIIIAPEHQGKGFARTLINRALDYSFTILNLHKIYLHVAVENPKAVHLYEECGFVEEGHLVEEFFINGRYQDVKRMYILQSKYLN 4mhd C 2.32 BS01 SPD B 1 H49 I50 D52 E55 R56 H48 I49 D51 E54 R55 Q9KL03 NSQLTLRALERGDLRFIHNLNNNRNIMSYWFEEPYESFDELEELYNKHIHDNAERRFVVEDAQKNLIGLVELIEINYIHRSAEFQIIIAPEHQGKGFARTLINRALDYSFTILNLHKIYLHVAVENPKAVHLYEECGFVEEGHLVEEFFINGRYQDVKRMYILQSKYLNRSE 4mhd C 2.32 BS02 SPD C 1 E33 Y36 E37 E41 E32 Y35 E36 E40 Q9KL03 NSQLTLRALERGDLRFIHNLNNNRNIMSYWFEEPYESFDELEELYNKHIHDNAERRFVVEDAQKNLIGLVELIEINYIHRSAEFQIIIAPEHQGKGFARTLINRALDYSFTILNLHKIYLHVAVENPKAVHLYEECGFVEEGHLVEEFFINGRYQDVKRMYILQSKYLNRSE 4mhv A 2.45 BS01 CA A 1 N101 I166 N169 N26 I91 N94 P15036 AVMSQALKATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKEN 4mi0 A 2.00 BS01 ZN A 1 C566 C580 C588 C601 C47 C61 C69 C82 2.1.1.43 Q15910 YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS 4mi0 A 2.00 BS05 ZN A 5 C523 H525 C530 C534 C4 H6 C11 C15 2.1.1.43 Q15910 YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS 4mk1 A 1.85 BS03 EDO A 1 N33 K34 A37 R124 S194 E195 N38 K39 A42 R129 S199 E200 M9V5A4 23978130 GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE 4mk1 A 1.85 BS04 27Y A 1 K34 I38 H41 E80 D108 E119 I120 K134 K39 I43 H46 E85 D113 E124 I125 K139 M9V5A4 23978130 GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE 4mk1 A 1.85 BS05 27Y A 2 A20 Y24 E26 K34 I38 E80 A25 Y29 E31 K39 I43 E85 M9V5A4 23978130 GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE 4mk1 A 1.85 BS06 27Y A 3 A20 E23 Y24 E80 G81 R82 D83 A25 E28 Y29 E85 G86 R87 D88 M9V5A4 23978130 GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE 4mk2 A 1.85 BS04 28B A 1 Y24 K34 I38 H41 E80 D108 E119 I120 K134 Y29 K39 I43 H46 E85 D113 E124 I125 K139 M9V5A4 23978130 GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE 4mk5 A 1.90 BS04 28A A 1 A20 Y24 E26 K34 I38 H41 E80 D108 E119 I120 K134 A25 Y29 E31 K39 I43 H46 E85 D113 E124 I125 K139 M9V5A4 23978130 GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE 4mle A 2.60 BS01 GLC A 1 S151 F152 P153 T168 K169 N204 D205 I225 N231 E256 Q287 E290 S138 F139 P140 T155 K156 N191 D192 I212 N218 E243 Q274 E277 2.7.1.2 P35557 24015910 TLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKAC 4mle A 2.60 BS02 VO1 A 1 Y61 V62 R63 S64 P66 I211 Y214 Y215 V452 V455 Y48 V49 R50 S51 P53 I198 Y201 Y202 V439 V442 2.7.1.2 P35557 24015910 TLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKAC 4mlh A 2.90 BS02 VO2 A 1 Y61 V62 R63 S64 P66 M210 I211 Y214 M235 L451 V452 V455 Y48 V49 R50 S51 P53 M197 I198 Y201 M222 L438 V439 V442 2.7.1.2 P35557 24015910 TLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKAC 4mnc A 1.05 BS01 173 A 1 F38 Y44 T94 A96 F97 F149 R168 S170 V172 Y173 W206 P207 E232 V233 F11 Y17 T67 A69 F70 F122 R141 S143 V145 Y146 W179 P180 E205 V206 Q122C7 QEVTLRLVSAFPENGIYVQRLLPWIAKVNAEGKGVLQINFLGGPKAIPTFEAGNAVKTGVVDMAMNTGAFYTNVMPEADFLKLTQIPVAEQRKNGAFDAINKVWNEKGNTQYLARMVENQPFHIYTNKKIDKPDLSGQKIRISPVYRDFFQALNANVVTTPPGEVYTALERGVVDGYGWPIGGIFDLNWQEKTKFRVDPGFYDAEVSLTMNLPAYKKLTDAQRNYLQKQLLVLEAENTFWTRYGNVETARQETAGIQTIKFDAATSKAFREKAYEVGWAGAMKQSPEVAARFKTLFSKAENLYFQ 4mnc A 1.05 BS02 173 A 2 I43 F266 R269 Y270 V273 I16 F239 R242 Y243 V246 Q122C7 QEVTLRLVSAFPENGIYVQRLLPWIAKVNAEGKGVLQINFLGGPKAIPTFEAGNAVKTGVVDMAMNTGAFYTNVMPEADFLKLTQIPVAEQRKNGAFDAINKVWNEKGNTQYLARMVENQPFHIYTNKKIDKPDLSGQKIRISPVYRDFFQALNANVVTTPPGEVYTALERGVVDGYGWPIGGIFDLNWQEKTKFRVDPGFYDAEVSLTMNLPAYKKLTDAQRNYLQKQLLVLEAENTFWTRYGNVETARQETAGIQTIKFDAATSKAFREKAYEVGWAGAMKQSPEVAARFKTLFSKAENLYFQ 4mni A 1.90 BS01 173 A 1 F38 Y44 T94 A96 F97 R168 S170 V172 Y173 W206 P207 A231 V233 F11 Y17 T67 A69 F70 R141 S143 V145 Y146 W179 P180 A204 V206 Q122C7 QEVTLRLVSAFPENGIYVQRLLPWIAKVNAEGKGVLQINFLGGPKAIPTFEAGNAVKTGVVDMAMNTGAFYTNVMPEADFLKLTQIPVAEQRKNGAFDAINKVWNEKGNTQYLARMVENQPFHIYTNKKIDKPDLSGQKIRISPVYRDFFQALNANVVTTPPGEVYTALERGVVDGYGWPIGGIFDLNWQEKTKFRVDPGFYDAEVSLTMNLPAYKKLTDAQRNYLQKQLLVLEAENTFWTRYGNVETARQETAGIQTIKFDAATSKAFREKAYEVGWAGAMKQSPEVAARFKTLFSKAENLYF 4mo1 A 2.10 BS01 ZN A 1 C118 C121 C144 C147 C57 C60 C83 C86 P03047 DKQKAINYLMQFAHKVSGKYRGVAKLEGNTKAKVLQVLATFAYADYCRSAATPGARCRDCHGTGRAVDIAKTELWGRVVEKECGRCKGVGYSRMPASAAYRAVTMLIPNLTQPTWSRTVKPLYDALVVQCHKEESIADNILNAVT 4mo9 A 1.93 BS01 TMO A 1 A45 R75 A28 R58 D1BQR9 PIEITDVTGRTVTLKKPAERVVLQWSGAGGPFFTISALMGKDTPKVIAGMDTSLQDYRADMWKHFTAEMPELAKIPVVGTIGDKTFNAEQVVALNPDVIFIPVDLKDQYESDAKAKMDAAGIQTIYIDYHAEKLESHQKSIEAIGKALGKEERAAEISKFYTNRVTRVLDRVSKINKPKPTVYLEVGMNGPEEFGNSFSGNYSWGALATMAGADVITKDAIKKSSPINPEFVLEKNPDIIMIMGSYWPKKPTSMRLGFEATEDSSQALLKAFTTERQGWSDLKAVENKQVYSAHHGLPREVFDAAVFEYLAKTFYPEEFKDVDPEATLKEFYDKFLPFSYSGIWFMHMN 4mpg A 1.95 BS01 GSH A 1 S11 Q12 P13 H40 K41 K53 L54 P55 E66 S67 R107 A235 S10 Q11 P12 H39 K40 K52 L53 P54 E65 S66 R106 A234 2.5.1.18 P0CG29 GLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDGDFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLGPLIGVQVPKEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALGYELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRIARIP 4mpg B 1.95 BS02 UNL B 1 V10 Q12 L35 W115 L119 V18 Q20 L43 W123 L127 2.5.1.18 P0CG29 DLGTEFQSMGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDGDFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLGPLIGVQVPKEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALGYELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRIARIP 4mph A 2.03 BS01 ZN A 1 H160 D167 H219 H98 D105 H157 Q81QA6 ASSFASVQAVVNKEYGLPEDYKPEDLVVPNVPFSFSGTLEKSYLRKEAAEALERLFDLANKEGIQLNAVSGFRSYDYQKKLYANNVKRFSAKPGHSEHQTGLTMDVSSKSANNELELTFANTKEGKWLKENAHRAGFIIRYPKGKESITGYAYEPWHIRYVGDIAESIYKKKLTLEEYMNL